@j this is especially true for those doing immunotherapy. I don't have the reference handy, but I read one study that found patients who had a "good" ...
@j this is especially true for those doing immunotherapy. I don't have the reference handy, but I read one study that found patients who had a "good" ...
From what I can tell, Immucura is selling snake oil. I asked them for more information about the antigens they were using to activate the dendritic ce...
@cl812271 In my opinion, the best thing you can do is get expression testing done on your tumor biopsy and figure out what's really going on in you...
thanks!!! if someone else has an issue with MDMX (MDM4), which is common. Pay attention to the splicing variant you are expressing. In my case t...
thanks for this I am starting on this combo (using Curqfen as the Curcumin source). I think I will be around 5uM of Celecoxib and 1uM of free Curcum...
There are chinese suppliers, but are they reliable? Anyone know about Vitamondo? but then getting it through customs ...
I will just add to this that my psa dropped by 40% after two fasts of 48 hours (two weeks between tests). My blood sugar got down to 60 and I was taki...
Hi Gge, Please take a look at the original paper I cited: It shows the impact of Diflunisal on lactate efflux not only alone, but in combinatio...
Hi gge, This is really helpful! That's now three human cases I know of. Two positive, one negative. Please share any details you can. Knowledge is k...
Hi gge, I'm separated from my computer right now, but when I get back I'll post some references that support the MCT1 inhibition effectiveness of d...
I think you may have missed the point of diflunisal+syro...you can't dose syro high enough orally to get effective MCT1 inhibition. You can, however, ...
@gge Hi gge, Take a look at figure 5C. That's the results of the in vivo experiment...only inhibition of growth. Unfortunately.
Great find. I hadn't seen that one. It's very useful to have another in vivo experiment, this time with actual data. Although it's disappointing that ...
This paper has a summary of the expression levels of MCT1 found in studies of different types of cancer. It was at least partially expressed in all st...
Hi GgE, I don't want to be negative. I just want to be realistic. There are soooo many research articles that show anti-cancer effects of drugs or n...
Well I spent a few days trying to find some kind of indication about the pharmacokinetics of Syrosingopine. I didn't find anything definitive, but wha...
@gge Interesting! When I first saw the patent numbers you are referring to, I noticed that they roughly corresponded with the practical range of hum...
@daniel Thanks so much Daniel! That's a perfect example of why this resource you've put together is so valuable. I'm 5 months into this journey ...
That was one of the parts of my post that I wanted to edit. It's unclear as written. The 50mg is already with the factor of 12 included! 7.5mg/kg/12*8...
unrelated: it would be really nice to be able to edit your posts to correct typos!
Diflunisal+Syrosingopine+Metformin The Syrosingopine/Metformin strategy is really interesting, but I have serious doubts about whether we can achiev...
"The mechanism of action likely involves both the methylation of tubulins and regulation of mitosis related gene by rMETase. S-adenosyl-L-methionine (...
Looking for ENO2 (gamma enolase) inhibitors, I only found SF2312, which is a recently discovered chemical never used in humans as far as I know. ENO2 ...
@haroldo-cazeao where are you located?
@daniel I didn't notice 2-DG in your list of drugs for coronavirus, but it's been confirmed to work in vitro:/p> The authors attribute this to block...