Bisphosphonates: Against Skeletal Lesions + Direct Anti-Tumor Action

Background: Many cancers either metastasize to the skeleton or grow primarily within the bone marrow, where this growth frequently leads to hypercalcemia, severe bone pain, skeletal destruction, and pathologic fractures. Indeed, the skeleton is the most common site of metastatic disease, and some of the patients with advanced cancer may develop skeletal lesions (Ref.). Bisphosphonates (BPs)
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Dimethyl Fumarate: An Anti Psoriasis Drug Works Against Tumors

Background: A recent press release from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) discuss the results of German researchers who demonstrated that dimethyl fumarate (DMF), a drug used to treat Psoriasis patients can also help in the fight against cancer. This study has been performed on lymphomas and DMF appears to have at least comparable effectiveness and is better
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Serotonin Makes Tumors Happy Too

Serotonin and its Role: Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system of humans. Serotonin is manufactured in the brain (dorsal raphe nucleus cells, which are located deep in the brain) and the intestines and is primarily stored in and transported by
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Itraconazole: An Antifungal Drug With Anti Cancer Properties

Background: Itraconazole is a FDA approved drug, developed as an orally administrated antifungal drug, and has been used clinically for many decades with a well-established safety record. It has been used in the prevention and treatment of a broad range of fungal infections, such as aspergillosis, blastomycosis, candidiasis, histoplasmosis, but also in various dermatological and nail infections. Since
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Cholesterol & Cancer: Inhibit ACAT to Kill Aggressive Cancers

Summary: Cholesterol is a lipid molecule present in the membranes of all mammalian cells and is essential for their growth and viability. As an indispensable constituent of plasma membranes, cholesterol affects properties and functions of membrane proteins such as receptors, enzymes, or ion channels. Cells produce cholesterol or are able to draw it from extracellular sources via
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Artemisia Annua, Artemisinin & 2015 Nobel Prize in Medicine

Background:  Artemisinin is a natural extract, coming out of a plant called Artemisia annua (sweet wormwood) used as a drug to treat malaria. It saved million of lives so far and as a results, its discoverer Mrs. Tu Youyou received the 2015 Nobel Prize in Physiology or Medicine (Ref.). Its discovery goes back to 1969. While the whole world
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Heparin: Great Value in Cancer Treatment

Background: Heparin is a widely used injectable blood thinner. It is typically administrated as an injection IP (anyone can do it at home) or Intra Venous. It is used to treat and prevent deep vein thrombosis and pulmonary embolism (collectively known as venous thromboembolism). According to Wikipedia, Heparin’s normal role in the body is unclear. Heparin
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How to potentially enhance Chemotheraphy effectivness

It is well know that tumors often develop resistance to (chemo) therapies via various mechanisms. Some of the mechanisms are well understood today and there are various drugs or supplements that may have the ability to suppress some of these resistance mechanisms. Bellow, I tried to cover most of the known resistance mechanism and indicate
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Cancer addiction to Cyst(e)ine & Lowering Glutathione inside cancer cells

Recently, I came across this nice article (Ref) which is in turn based on a recent publication (Ref.) arguing that in some types of renal cancer cells, cystine deprivation “presents an attractive therapeutic opportunity that may bypass the apoptosis-evading mechanisms characteristic of drug-resistant tumor cells.” However, as we will see Cysteine is relevant not only in renal cancer but in most of
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A Natural Painkiller and Anti-Inflammatory: Palmitoylethanolamide (PEA)

Summary: PEA is a body-own fatty compound, and is produced by our own living cells to restore balance in chronic pain and chronic inflammation. Its anti-inflammatory and painkilling properties are known in science many decades since the first description of this compound in 1957. in 1993 the Nobel price winner professor Rita Levi-Montalcini pointed out
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Another weak spot of cancer cells: ATP citrate lyase inhibition

ATP citrate lyase is an important enzyme for he fast dividing cancer cells ATP citrate lyase (ACL or ACLY) is an intracellular enzyme (located in cytosol) responsible for the conversion of citrate that comes out of the mitochondria,  to acetyl-CoA and oxaloacetate. ATP citrate lyase is primarily expressed in lipogenic tissues. Other vegetative tissues express little to
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Phosphoethanolamine & Meclizine: inhibiting an enzyme required to form the building blocks of membranes

Summary Actually, the title (inhibiting an enzyme required to form the building blocks of membranes) refers to Meclizine since as we will shortly discuss below, Phosphoethanolamine acts (probably) on mitochondria. The compound, Phosphoethanolamine, has been shown to kill tumor cells (A. K. Ferreira et al. Anticancer Res.32, 95€“104; 2012) at the University of S£o Paulo in Brazil. As a result some
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Perillyl Alcohol (POH) for brain tumors via nasal spray

Summary A less known but very effective natural anti cancer element, Perillyl alcohol is isolated from the essential oils of several plants including citrus, cherries, lavender, peppermint, spearmint, celery seeds, sage, cranberries, lemongrass, ginger grass, etc. Accessible at Medicor (see below) or it can be ordered from chemical suppliers under the CAS 18457-55-1. Oral administration has lead
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