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Daniel RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Daniel, 16 hours ago

Metabolic Inhibitors
  @jcancom Yes J, I will send it now. Kind regards, Daniel
Jcancom RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Jcancom, 1 day ago

Metabolic Inhibitors
  @daniel, D might you share Ray's email with me? Best Wishes, Jcancom
Ray Donnelly RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Ray Donnelly, 1 day ago

Metabolic Inhibitors
  @jcancom Sure thing.
Jcancom RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Jcancom, 1 day ago

Metabolic Inhibitors
  Ray, would you like to go off thread for additional discussion? D requires explicit consent to release poster's email addresses. Let's join johan's good example and migrate to the part 3 thread. I...
johan RE: Combo Metformin and Syrosingopine!!!! Looks Awesome! (Part 3)  

By johan, 1 day ago

Metabolic Inhibitors
  Berberine protects against metformin-associated lactic acidosis in induced diabetes mellitus
Ray Donnelly RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Ray Donnelly, 1 day ago

Metabolic Inhibitors
  Thanks @jpizzuto, it's good to lay it out so clearly, I'll probably keep my dosing where it is for now. I need to sort out my cholesterol ASAP though.
Ray Donnelly RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Ray Donnelly, 1 day ago

Metabolic Inhibitors
  @jcancom, my latest pet report is in Spanish and it's been such a whirlwind (as has life outside of cancer, but not in a bad way all the time) that I've not translated it yet. I'll do a Google transla...
John Pizzuto RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By John Pizzuto, 1 day ago

Metabolic Inhibitors
  @ray-donnelly From the patent, calculating the max recommended daily amount for your weight: 62/70 x 1.5 ---> 1330mg metformin. You could round it down to 1250mg or 1000mg. If you choose 1250mg, ...
Ray Donnelly RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Ray Donnelly, 1 day ago

Metabolic Inhibitors
  @jpizzuto Good news! Do you think I should reduce my dose too? I'm about 62kg.
John Pizzuto RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By John Pizzuto, 2 days ago

Metabolic Inhibitors
  @matsim I have asked Daniel to remove the inaccurate portion of my post upthread, advocating a large dose of metformin. For my wife, it looks like 1000mg is plenty, so I don't see a need to explore in...
Jcancom RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Jcancom, 2 days ago

Metabolic Inhibitors
  Matsim, thank you for your comment about the lactate monitor. The articles on syromet, noted that there is a path through gamma-enolase for resistance. However, one might also imagine other potential ...
Jcancom RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Jcancom, 2 days ago

Metabolic Inhibitors
  Ray, I am glad that you are interested in the lactate monitor and I agree that the K'Watch is unfortunately still somewhat on the horizon. It is still uncertain to me why lactate is not more of a stan...
Matsim RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Matsim, 2 days ago

Metabolic Inhibitors
  @jpizzuto, I didn't think there was a difference between the site and the document. Thank you for explaining it to me in detail. Wish you to find the best ratio of both medicines and your wife to find...
John Pizzuto RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By John Pizzuto, 2 days ago

Metabolic Inhibitors
  @matsim You are correct, I assumed 2.55g metformin for a 70kg person, which is too much. When you open the patent, you will see there are some spelling and punctuation errors, so click the button that...
Matsim RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Matsim, 2 days ago

Metabolic Inhibitors
  @jpizzuto ,I'm not sure how you achieve your calculations, and 2.55g max Metformin dosage. The result showing 19.6mg Syrosingopine for a 70 kg person really bothers me. Please, let me share my calcula...
finnan RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By finnan, 2 days ago

Metabolic Inhibitors
  @ray-donnelly Have you considered going in a vegan keto direction to lower your cholesterol:
John Pizzuto RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By John Pizzuto, 2 days ago

Metabolic Inhibitors
  Looking for a way to administer metformin, studying this paper about rectal suppositories:
Manuone RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Manuone, 3 days ago

Metabolic Inhibitors
  Hi guys! Reviewing the publication on Daniel's "a list of mitochondrial inhibitors" I saw an update of the month of July with the following article in Nature: The Panhematin drug seems to make mitocho...
Daniel RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Daniel, 3 days ago

Metabolic Inhibitors
  @ray-donnelly Ray, HCA and others discussed here may help with that
Ray Donnelly RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Ray Donnelly, 3 days ago

Metabolic Inhibitors
  I've done a bit more looking into my details of when I had the chemo break and started syromet. My last chemo before the break on 20th October and I had the scan on the 5th November. Chemo resumed aro...
John Pizzuto RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By John Pizzuto, 3 days ago

Metabolic Inhibitors
  @matsim Thank you for the patent link. I'm embarrassed to say I have looked at it but never studied it until now. It states the weight to weight ratio between syro and metformin should be in the ran...
Matsim RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Matsim, 3 days ago

Metabolic Inhibitors
  To all, According the information Ray Donnelly gave us about his labs data (Thank you, @ray-donnelly very much for sharing it), which is the best approach to start this combination? How you are consid...
Matsim RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Matsim, 3 days ago

Metabolic Inhibitors
  Posted by: @jcancom You would then have a much better idea when syromet was losing effectiveness far in advance of when your CEA readings finally called the turn. Which way you considering for cance...
Ray Donnelly RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Ray Donnelly, 3 days ago

Metabolic Inhibitors
  Hey all. New readings: 04/12/2019 CEA 5.4 C199 152. Of note is that my cholesterol levels are high, 401 and 265. Any recommendations for that?
John Pizzuto RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By John Pizzuto, 3 days ago

Metabolic Inhibitors
  @jcancom The syro/met combo blocks MCT1 and MCT4 and NADH recycling--->cancer cell death. Wondering how normal cells survive, without going back to read the Benjamin research paper, I went off on a...
Jcancom RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Jcancom, 3 days ago

Metabolic Inhibitors
  JohnnyP, this is great that you have found a formulation of metformin that might avoid the side effects encountered to date. I am glad that you are cautious about the route of administration as syrome...
Jcancom RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Jcancom, 3 days ago

Metabolic Inhibitors
  Ray, this is how I understand the lab reports that you posted. For the first 2 months, your chemo was able to slightly depress your CEA. So there was at least some chemo restraining power. This would ...
nissim need help - nausea/ bad feeling due to taking many pills - possible reasons/ ways to overcome?  

By nissim, 3 days ago

Forum to discuss treatment protocols and drug/supplement cocktails
  Hi, I would appreciate any help and advice from your experience and knowledge, My brother (45 years old with GBM bran cancer) is treated in the last 4 months by 6 weeks cycles of adjuvant 6 days c...
Ray Donnelly RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Ray Donnelly, 3 days ago

Metabolic Inhibitors
  I am happy to get a lactate monitor. I don't think waiting for this K'Watch one sounds wise as there's no indication of when or even if I can get one. I'll have to be brave and draw blood for you guys...
Jcancom RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!  

By Jcancom, 3 days ago

Metabolic Inhibitors
  Thank you, Manuone! Thank you! I have been out in the wilderness for a few years with the lactate monitor idea and no one seemed interested. I did not like trying to shake down Ray for the 300, though...
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