Synergy between mebendazole and methionine depletion (vegan diet)
I have been taking mebendazole and eating vegan/limiting total protein intake in order to keep methionine intake to 800mg a day. I came across this today, which shows methionine depletion and mebendazole are synergistic (more than additive effects). Of course the results are for depletion, not restriction, but still promising...
and inhibiting BCL-2 is an important part of the equation:
"The mechanism of action likely involves both the methylation of tubulins and regulation of mitosis related gene by rMETase. S-adenosyl-L-methionine (SAM), produced from methionine and ATP, is the universal methyl donor in prokaryotes and eukaryotes and reduction of SAM compromises protein methylation. Methionine appears to be critical for the methylation of actins and tubulins in maintaining cellular stability35 and SAM is known to stabilize microtubule polymerization and reduce micronuclei formation.36 Thus, it is likely rMETase reduces methylation of tubulins, further destabilizing microtubules when tumor cells are subjected to depolymerization agents. On the other hand, rMETase can up-regulate (CDKN1A, and MDA1, etc) or down-regulate(CDKN2B, and Aurora Kinase B, etc).16, 17 The change in their genes expression levels is associated with the loss of mitosis in tumor cells.16 rMETase-induced genetic alteration shows the multifaceted effect of methionine deprivation,16, 17 which can explain the highly effective synergism between rMETase and a variety of diverse chemotherapies tested."
Thank you! Very interesting and relevant! Combining methionine depletion with e.g. Griseofulvin, or Mebendazole, or Ivermectin, or Fenbendazole would make sense.
I hope you will see good results with this approach.
High levels of methionine can be found in eggs, meat, and fish; sesame seeds, Brazil nuts, and some other plant seeds; and cereal grains. Most fruits and vegetables contain very little. Most legumes, though protein dense, are low in methionine.
However, since methionine is an essential amino acid, it cannot be entirely removed from animals' diets without disease or death occurring over time. For example, rats fed a diet without methionine and choline developed steatohepatitis (fatty liver) and anemia, and lost two-thirds of their body weight over 5 weeks. Administration of methionine ameliorated the pathological consequences of methionine deprivation. Short-term removal of only methionine from the diet can reverse diet-induced obesity and promotes insulin sensitivity in mice, and methionine restriction also protects a mouse model of spontaneous, polygenic obesity and diabetes
Loss of methionine has been linked to senile greying of hair. Its lack leads to a buildup of hydrogen peroxide in hair follicles, a reduction in tyrosinase effectiveness, and a gradual loss of hair color.Methionine raises the intracellular concentration of GSH, thereby promoting antioxidant mediated cell defense and redox regulation.