Introduction:
Methylglyoxal, a molecule also produce by human body, it is one of the substances with an anti cancer potential that stands out.
I am enthusiast about it because of the following facts:
- It has clear science behind supported by a large amount of academic research
- Its anti cancer potential has been already demonstrated in humans
- It can eradicate most cancer types
- Its anti cancer action was even indicated by a Nobel Prize winner in multiple publications in the prestigious magazine “Science”
- It is cheap
- Relatively easy accessible and can be administrated orally
- Low to no toxicity to normal cells
I will start this article with a number of major historical facts indicating the potential behind Methylglyoxal:
- At the begging of the last century …
Dr. William F. Koch (1885-1967) (appointed Professor of Physiology at the Detroit College of Medicine in 1914, and subsequently became Chairman of that Department) published a paper entitled “A NEW AND SUCCESSFUL TREATMENT AND DIAGNOSIS OF CANCER”. In this paper he was stating the following: “This substance when purified, taken up in water and immediately injected subcutaneously into a cancer patient, causes practically no local reaction; but instead, after about 24 hours, a very decided focal reaction takes place. Wherever the cancer tissue may be, its’ cells are killed, their ionic concentration increases, the osmotic pressure increases, they take up water, swell and disintegrate. The swelling causes pain and the absorbed, disintegrated products are oxidized causing fever.”“Those two things, focal pain and fever, constitute a reaction which lasts all the way from 6 to 48 hours, depending upon the amount of cancer tissue killed, and of course this depends upon the quantity of substance injected. Such a reaction occurs only in cancer cases and only in the presence of cancer tissue. After the cancer tissue has disappeared, no more reaction can be elicited, no matter how large an injection is given, an important diagnostic aid. The specificity of the substance for cancer is evidenced by the fact that while giving these injections in rapid succession (that is daily or every two days for a period of five weeks), a blood count will rise from 2,850,000 to 4,600,000 red cells and the haemeglobin from 37% to 82%. Thus the delicate red cells are not injured. At the same time a mass of cancer tissue, the size of a large cabbage, will entirely disappear, and all the signs and symptoms of the particular cancer will disappear with it, function return, and the patient become clinically cured.“Stomach, liver and rectal cancers clear up the quickest. Uterus cancer responds slightly more slowly. Squamous cell carcinoma responds about one-half as fast as stomach cancer.” (Ref.)With his therapy W Koch successfully treated various cancer types. Here are a few examples of successful cases http://www.williamfkoch.com/web/version2/drkoch.php?id=151.0&dispID=disp(2);%20disp(3). There is so much to say about what happen following the success of Prof. Dr. William F. Koch, and at this link you can read all in details, but on short, unfortunately for the general health, Dr. Koch was never given the research facilities and cooperation by the medical profession he had asked for and wanted.
.
Here are a few pieces of information that can give us a view on the drug used by Dr. Koch:
– Once, Dr. Koch stated about his anti cancer substance the following: “The compound is difficult to make and it deteriorates rapidly. If I published it and quacks or unscientific men started mixing it and treating cancer with it, the results would be disastrous, not only possibly to the patients, but to the ultimate success of the treatment. Improperly mixed or administered the compound would fail to do its work.” (Ref.)
– In another article this is what I found: It was an oxygen uptake product of some kind. The formula was O = C = C = O. According to the formula that Koch published it was a 10e-6 dilution, i.e. homeopathic formulation. He called this substance Glyoxylide (Ref.)
– And here is another piece of info on his formula: The theory that Koch had was one in which he equated the dilution of his product to enzymes in the blood
.
So, despite offers, he never made the formula for his medicine available to medical groups or drug companies, for fear they would change and pervert it.
.
The substance that Koch suggested he was using was O = C = C = O, and it was considered essentially nothing by FDA. Her is a quote “The formula was O = C = C = O, which means nothing, really” (Ref.) As a result, his drug was classified as a fraud by the FDA (Ref.).
.
quackwatch.com is stating the following about Koch’s glyoxylide: “Does Koch’s glyoxylide exist? The molecule glyoxylide has been a subject of investigation by chemists including H. Staudinger in 1913 [4] to Berson in 1986 [5]. Recently Sulzle [6] reviewed the literature and considered the theoretical possibilities for the existence of a compound like glyoxylide. He found that all efforts to prepare, isolate, or chemically identify this compound failed. His studies on the theoretical physical chemistry of glyoxylide showed that the substance described by Koch cannot exist in nature. This, along with Jenssen’s failure to find anything in Koch’s “medicine” [3], confirms the conclusion that the glyoxylide which Koch claims to have invented did not exist.” However …
.
… Nearly 100 years latter, during 2015, here is a headline from the scientific news: “Existence of elusive molecule confirmed after more than a century”. (Ref.) This shows how scientist at University of Arizona, USA, have discovered a small molecule with only four atoms that was “never been observed, neither as a substance nor as a transient species, despite a century-long history of attempts”. And guess what was the molecule discovered? That was exactly O = C = C = O (OCCO), the same that dr. Koch was suggesting he was using to treat cancer and FDA was saying that it doesn’t exist :). This simple molecule was so hard to find because it splits into two carbon monoxide (CO) fragments after half a nanosecond or so of existence. The discovery was made in Sanov’s lab, when his graduate students were experimenting with glyoxal – a chemical compound with the formula OCHCHO. (Ref.). So Koch’s OCCO precursor is actually glyoxal. OCCO is now called ethylenedione. The relation between Koch’s work and Glyoxal is also shortly discussed here.
.
This proves the fact that if you don’t see it doesn’t mean automatically that it doesn’t exist. It also means, quackwatch and FDA were wrong and need to update their statements on the above.
.
Therefore, Koch succeeded to find a way to synthesizing OCCO and keep it stable somehow until giving it to the patient or use substances that would trigger its production in the human body (Ref.), and with this cure c. and other diseases. For more information on Koch’s story please see williamfkoch.com, a site maintained by the Koch family.
. - In the middle of the last century …
Dr. Albert Szent-Gyorgyi was the Nobel Laureate in Medicine in 1937 for the isolation and discovery of Vitamin C. (Ref.) he also discovered Iso-Flavones and vitamin P. In his last 40 years, he researched the regulatory processes of cell growth, and thereby the regulation of cancer itself.
.
As early as 1958, Szent-Györgyi also worked on Methylglyoxal and together with his collaborators, in their pioneering work on the biological role of Methylglyoxal, had put forward strong evidences for the anti-cancer and tumor growth inhibitory effect of Methylglyoxal. For example, they showed that Methylglyoxal could completely inhibit the tumor development in mice. Here is the ‘Science’ paper published in 1968: Cancerostatic Action of Methylglyoxal.
.
Even earlier than that, in 1963, the prestigious magazine ‘Science’ published a remarkable article about his research. In it Dr. Szent-Gyorgyi identified two substances, one called Retine, which inhibited cancer growth (ascites tumors), and the other called Promine, which promoted cell growth and made cancer grow faster. (Ref.) He suggested that these were very small molecules that were highly potent in controlling cell division. His research using mice achieved shrinkage of tumors by increasing the ratio of Retine to Promine with daily injections of Retine. Other researchers obtained similar results and there were no harmful or toxic side effects.
.
In another article in Science he announced that they have succeeded to extract Retine from human urine. (Ref.) I find this interesting since urine therapy as an anticancer approach was/is a technique used by some. And here is another article referring to glyoxal offering a hopeful target in the search for cancerostatic substances (Ref.) and more on his view on methylglyoxal (Ref.) In 1967 he announced that his laboratory had isolated and manufactured Retine (retards cell growth) in the form of a Carbonyl compound called Methylglyoxal. (Ref.)
.
In an interview in Prevention magazine in 1972 conducted by Jane Kinderlehrer, he explained that he and “Dr. Egyud have found that retine (methylglyoxal) stops the growth of cancer cells without poisoning other cells. When retine is present in sufficient concentration, no cell division can occur while vital cellular processes go on unhindered. And what is a good bit of luck, and not my cleverness, the white-haired scientist pointed out, is that if a cancer cell cannot grow, it dies by itself.” According to the researchers, retine is normally produced by the body and, when it is, it prevents the growth of existing cancer cells. But the body can lose its ability to produce this substance… “Putting the retine back in the body, just as we put insulin back into a diabetics body, can stop the growth of cancer… ” (Ref.)
.
Dr. Szent-Gyorgyi acknowledged the work of Dr. William Koch on the same subject saying, “A decade ago, a very intuitive researcher, Dr. William F. Koch, came to the same conclusion about the possible importance of Carbonyls in regulation of cell division and carcinostasis.”
. - At the end of the last century and beginning of our century …
About 50 years latter Prof. dr. Manju Ray, a very good Indian scientist in Molecular Enzymology and Cancer Biochemistry, build on Methyloglyoxal’s anti cancer effects. In a series of papers, she further demonstrated the potential of Methyloglyoxal. But she did not stop to the theory. Instead she trialed the drug on 19 patients with very advanced stages of cancer and resulted in an overall cure rate of 70 percent in cancer patients who were diagnosed as terminally ill, results presented in 2001.
.
In 2006 Prof. Dr. Manju Ray, presented a 5 year follow-up phase II study with methylglyoxal. It showed that of the 46 patients enrolled, 18 were in complete remission (so there were no tumors in clinical scans to see). The follow-up after 5 years of the patients took an average of 4 to 56 months. The results of the study showed that 18 (39%) patients achieved a complete remission, 18 (39%) patients had partial regression and / or stable disease, while 8 (17%) patients had progression of their disease.” After this, another successful clinical trial was conducted (see below).
.
With all these results in humans, Prof. Ray clearly underpinned the great anticancer effect of Methylglyoxal.
Other facts:
- Methylglyoxal can also enable or increase the effectiveness of DNA disrupting chemo therapy (Ref.).
- Ketogenic Diet seems to also increase intracellular Methylglyoxal (Ref.)
- Methylglyoxal can be also found in Manuka Honey in concentration of about 250mg/kg and it is
believed to be responsible for the antibacterial and antiviral activity of the honey. (Ref.) Professor Thomas Henle of University of Dresden, Germany announced in 2008 that research “unambiguously demonstrates for the first time that Methylglyoxal is directly responsible for the antibacterial activity of Manuka honey.” http://www.manukaonline.com/mgo-Manuka-Honey-benefits.html - However, note that while the amount of Methylglyoxal present in the honey (250mg/kg) may serve as a good preventive measure, for cancer treatment purpose this is too little. Given the Methylglyoxal dose that is proposed to cure c. (see the Dose and Administration section below), we would need to eat kilograms of honey each day, which is not feasible. This is why, as it will be further discussed, other sources of Methylglyoxal are used in the clinical trails.
Other interesting articles to read:
In conclusion, the anticancer effect of methylglyoxal has been known for a long time. But relatively recent work has shown that it acts exclusively against malignant cellular mitochondrial complex I and GAPDH to elicit its anticancer effect. It has been used on humans and found that
- methylglyoxal is potentially safe for human consumption and able to destroy cancer cells in vivo
- a methylglyoxal-based anticancer formulation was administered orally to diverse groups of cancer patients in India
- In first group (14 months, January 2000-February 2001) 24 patients were recruited and complete remission was observed for 11 patients and partial remission for 5 patients.
- In the second group (60 months, October 2000-September 2005) 46 patients were recruited and complete remission was observed for 18 patients and partial remission for 18 patients.
- In the third group (42 months, May 2005-October 2008) of the 23 patients complete remission was observed for 11 patients and partial remission for 7 patients.
- The treatment was found to be especially effective for adenocarcinoma of urinary bladder, breast, uterus, esophageal and gastrointestinal tract cancer.
- Several vital biochemical, radiological and other parameters were tested in patients who received treatment for a long time to assess the possible long term toxicity of methylglyoxal treatment, if any, and the results implicated no toxicity as per the parameter studied.
- All the results showed great promise of methylglyoxal treatment and demands further improvisation the methylglyoxal based therapeutics. (Ref.)
- Due to its mechanims of action it could complement anticancer strategies involving Chemo, 3BP, DCA, Artemisinin, and any other pro oxidant drug.
Methylglyoxal as anti cancer treatment in Humans: Clinical trials
A methylglyoxal-based anticancer formulation was developed and a three-phase study of treating a total number of 86 cancer patients was carried out. The results appear to be promising. Most of the cancer patients benefited greatly and a significant number of patients became free of the disease. Contrary to the effect of existing anticancer drugs, this methylglyoxal-based formulation is devoid of any toxic effect and reasonably effective against a wide variety of cancers. (Ref.)
Here are the result from one of the study 46 patients:
Previous in vitro and in vivo studies had shown remarkable anticancer effect of methylglyoxal. A recent toxicological study with four different species of animals has shown that methylglyoxal is potentially safe for human consumption (Ghosh et al, 2006). We have developed an anticancer formulation with methylglyoxal as the principal ingredient. To test the efficacy of this formulation, 46 patients suffering from different types of malignancies in different stages of the disease were randomly chosen: brain –2, head and neck –2, gastrointestinal –11, lung –6, gynecological –6, breast –3, urological –4, hematological –2, prostate –2, gall bladder –1, pancreas –2, others –5. The effect of the formulation on overall survival, regression of the tumours and general well being of the patients were analyzed. The follow-up of the patients ranged from 4–56 months. The results of the study show that 18 (39%) patients had complete remission, 18 (39%) patients had partial regression and/or stable disease condition, whereas 8 (17%) patients had progressive disease. In addition to the measurable improvement of the majority of the patients there was remarkable improvement in the quality of life of nearly all the patients. There was no significant adverse side effect in almost all the patients. The significant antitumour effect of methylglyoxal against a wide variety of cancer suggests that all the different types of cancer may have common altered site(s). Our next task will be to further improve this treatment and to evaluate its efficacy with a large number of patients. http://www.cancer-therapy.org/pdf/CT%204B.pdf (if at any point this link doesn’t work please contact me – I have the PDF available).
Clearly, the results are great as they indicate 78% response rate, including 39% complete remission.
Anecdotal stories
- a patient in the Netherlands keeping his cancer under control from 2001 to 2005 with MG. Doctors recognising the patient would not be there in 2005 without MG (Ref.)
Mechanism:
Methylglyoxal (MG) is a highly reactive dicarbonyl compound and a potent glycating agent, mainly generated as a by-product of glycolysis through a spontaneous degradation of triosephosphates. In cancer, since the glycolytic pathways is highly active there is a lot of Methylglyoxal being produced. That is even more during the administration of DNA disrupting agents such as some of chemotheraphies (see next paragraph). Figure below shows how Methylglyoxal is produced inside the cell.
Figure is from: Analysis of methylglyoxal metabolism in CHO cells grown in culture
The cellular response to antitumour drugs that modified DNA or disrupt DNA metabolism is to activate processes of DNA repair, including poly(ADP-ribose) polymerase. This depletes cells of NAD+ such that glyceraldehyde-3-phosphate dehydrogenase activity is depleted and triosephosphates, glyceraldehyde-3-phosphate and dihydroxyacetonephosphate, increase. Methylglyoxal is formed mainly by triosephosphate degradation and since triosephosphates is increased strongly during the DNA repair, a consequent dramatic increase in methylglyoxal formation is expected. The increase of methylglyoxal will be negative for cancer cell potentiating for example the cytotoxic effect of the antitumour agents. As a result, to block methylglyoxal, the cancer cell will over express of Glo1 (Ref.)
Indeed, it has been shown that in mammalian cells, MG is detoxified by the glyoxalase system, an enzymatic pathway consisting of two enzymes called glyoxalase 1 (Glo-1) and glyoxalase 2 (Glo-2) and is based on reduced glutathione (GSH). It has been shown that Glo-1 expression and activity is increased in many human cancer types such as colon, prostate, melanoma, lung, and breast and that Glo-1 overexpression is correlated with cancer progression and drug resistance (Ref.).
Accumulation of Methylglyoxal in cancer cells are known to lead to the inhibition of Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) (Ref1, Ref2, Ref3), an essential enzyme acting in the glycolsisis pathway. GAPDH inhibition depletes ATP profoundly depriving the cancer cells of energy. Note that 3-bromopyruvate (3BP) is also inhibiting (GAPDH) (Ref1., Ref2.).
Next to GAPDH inhibition, Methylglyoxal induces mitochondria-dependent apoptosis http://www.ncbi.nlm.nih.gov/pubmed/22098242
One of the potential anticancer mechanisms of MG may be related to GABA A receptor. This is because MG seems to be an activator of GABA A receptor (Ref.). And GABA is known to show anti cancer activity via the GABA A receptor (Ref.1, Ref.2).
As a side note the activation of GABA A receptor triggers an influx of Cl- ions (Ref.).
Dose and Administration:
MG oral administration:
According to the clinical trial above (Ref.):
- 30mg methylglyoxal/kg of body weight/day
- this was divided in 4 administration/day (i.e. 7.5mg/kg/administration)
- each dose was followed by a tablet of chewable vitamin C containing 400 mg of sodium ascorbate
- Taking the drug on an empty stomach is NOT recommended
- Each patient also received orally a mixture of the B vitamins twice a day: B15mg, B6 2.5 mg, B12 5 mg and B5 7.5 mg. This mixture is usually a standard composition of vitamin B complex available
- The duration of treatment at the same or at a reduced dose was determined by evaluating the response and general condition of the patient
Now here is how to translate the above dose into what the chemical suppliers are selling:
- Sigma and others provide 40% MG concentration in water
- The density of MG is 1.17g/ml at 25C; this means that each ml of 40% MG contains 468mg MG
- Since the dose suggested for a day is 30mg/kg, a person of 50kg will need 1500mg MG/day
- Since each ml of 40% MG contains 468mg MG, the 50kg patient would need 3.2ml of 40% MG each day
- As a result 0.8ml of 40%MG has to be administrated 4x/day
- As suggested in the clinical trial, each of the 0.8ml will be administrated with 60ml water (i.e. in a small glass of water) after meal
Note: in addition to Vitamin B and Vitamin C suggested in the clinical trial I would also add Curcumin capsules (8g/day or lower if this is not possible) to inhibit glyoxalase 1 and possibly increase the effectiveness of MG treatment. Here is a patent that is suggesting the same https://www.google.com/patents/US8163796
15.05.2016: Update on formulation and dose: I was just informed by one of the readers in contact with dr. Ray that in case of very aggressive cancers she is now suggesting 40mg/kg/day dose. Here is a quote of the info I received: “40 mg/Kg/day. 5 ml of her formulations has to be taken with half a cup of water/fruit juice after meal/snack four times a day, followed by one 500 mg chew-able Vitamin C (2000 mg daily total), and two tablet Polybion after lunch and dinner.”
23.05.2016: Update on formulation, dose and administration following conversation with Prof. Manju Ray:
- Methylglyoxal (MG) used is available commercially as 40% aqueous solution
- We now use 40 mg/kg/day in four divided doses
- For example a person of 50 kg will need 2000 mg MG in four divided
doses/day - 40% methylglyoxal means 40 gm/100 ml (irrespective of density)
- Take 100 ml of 40% solution, add 300 ml of water (preferably distilled water)
- Total vol of diluted solution is 400 ml
- 400 ml contains 40000 mg,
- so a person of 50kg that needs 2000 mg/day will use 20ml of this diluted solution every day, in 4 devided doses, each of 5ml
- Mix 5 ml of diluted solution with 50-75 ml of water or fruit juice and give the patient to drink
- Such a dose should be given 4 times daily in 5-6 hrs intervals
- After each dose of methylglyoxal, 1 tab of chewable Vit C = 500 mg should be chewed (not swallow)
- tablet of Polybion after lunch and dinner is OK
- Curcumin is OK
- My addition: Creatine supplement is a must 30-60 min prior to MG administration (see below why)
Although in the clinical studies they did not used Creatine, following these statements, I would clearly make sure that (maybe 30-60 minutes) prior to each MG administration there is a Creatine supplement administer too.
Update on 21-June-2016:
MG IV administration:
Based on recent discussions with prof Manju Ray here is a dose that makes sense:
.
Koch formulations administration:
“A successful product if taken sublingually will be tasteless at first. Then within a few minutes a slightly astringent (cotton mouth) feeling will be experienced followed by a metallic taste. Many will go on to experience a transient warm flushed feeling several minutes later, and/or feelings of increased pep and mental alertness. Those subjects having allergic symptoms will usually experience relief within a few minutes. If one or more of the above occur, the product should be considered good. The product need not be injected, but can be administered sublingually or by aerosol.”http://bioredox.mysite.com/OCThtml/howmade.htm
Koch formulations are:
It is recommended to be given
- 1 Vial per day for 10 days- then –
- 1 Vial per week for 10 weeks- then –
- 1 Vial per month for the balance or until vials are gone. (Ref.)
Other sources are suggesting
- 1 Vial each day during 14 days
Regardless of the approach, the Vials are alternated, e.g. first day one vial Rhodizonsaure, second day one vial Carbonylgruppen, next day again one vial Rhodizonsaure and so on. (Ref.)
In acute conditions 1-3 times daily 1 ampoule (of 2ml) injected intramuscularly (im) or subcutaneously (sc). (Ref.) The vial can be administrated sublingual but is is preferred via injection, i.m. or s.c.
More about the therapy in German: http://www.windstosser-museum.info/museum/manuskript/aufklaerung/25.pdf (use google translator to translate)
Chitosan formulation:
Here is an e-mail I received from a friend from Cancer Compass (Jcancom) on a new formulation:
Dear Daniel:
An even more recent patent that you sent me was using at most 0.5mg/kg/day methylglyoxal in a chitosan encapsulation. This would be even better. The instructions they give seem easy to do. I wonder whether this formulation could be bought somewhere? https://www.google.com/patents/WO2015049689A1?cl=en
Sincerely,
Jcancom
Here are a few articles on the same MG-chitosan combination:
- Immunomodulation of macrophages by methylglyoxal conjugated with chitosan nanoparticles against Sarcoma-180 tumor in mice http://www.sciencedirect.com/science/article/pii/S0008874913001901
- Nanofabrication of methylglyoxal with chitosan biopolymer: a potential tool for enhancement of its anticancer effect
I will soon have a look at the encapsulation of MG with chitosan since this is probably a much better route of administration, and chitosan is available and cheap. As soon as I have news on this I will update the page.
Synergy and Antagonism:
Creatine: New paper published in 2016 from dr. Roy, suggesting Creatine as supporting MG treatment: These data strongly suggest that creatine supplementation may gain importance as a safe and effective supplement in therapeutic intervention with the anti-cancer agent MG. http://www.ncbi.nlm.nih.gov/pubmed/27138627
Glyoxalase I inhibitors: inhibition of GLO1 leads to the intracellular accumulation of methylglyoxal. The natural extracts Naringin (Ref.) and Curcumin (Ref.) are known to act as GLO1 inhibitors.
Nrf2 I inhibitors: Besides GLO1, Nrf2 favour the survival of cancer cells by protecting them from excessive dicarbonyl and/or oxidative stress (Ref.) Nrf2 is often referred to as the main activator of cellular antioxidant response but it is also the main regulator of GLO1 and AKRs expression thus playing a central role in cell response to MG stress. Nrf2 inhibitors are discussed here (Ref.) and include Ascorbic Acid.
Ascorbic acid: http://www.ncbi.nlm.nih.gov/pubmed/16112157 http://www.ncbi.nlm.nih.gov/pubmed/1995489
GABA:
One of the potential anticancer mechanisms of MG may be related to GABA A receptor. This is because MG seems to be an activator of GABA A receptor (Ref.). And GABA is known to show anti cancer activity via the GABA A receptor (Ref.1, Ref.2). Therefore, combining MG treatment with GABA supplementation may increase the chance for a successful treatment. GABA is a commercially available supplement.
Dichloroacetate (DCA):
MG triggers GABA A receptor activation which in turn triggers an influx of Cl- ions (Ref.). Intracellular Cl- on the other hand is expected to reduce DCA’s anti cancer activity as it will reduce the efficiency of the DCA-induced GSTZ1 inactivation process (Ref.). As a result, I would not combine MG with DCA.
Update 10-March-2017: Metformin:
A great anti cancer drug, accessible and low/no side effects, but according to this article, unfortunately, Metformin may increase the Glo1 activity and as a result reduce MG effectiveness. Thus, Metformin should not be combined with MG: https://www.ncbi.nlm.nih.gov/pubmed/24710646
Safety:
Based on an anecdotal report, a patient receiving MG got seven / eight weeks after he started with the methylglyoxal high fever, (41degrees). He stopped for one week MG and started again with no other issues. (Ref.)
Overall, the potential beneficial effects of methylglyoxal far outweigh its possible toxic role in vivo, and it should be utilized for the benefit of suffering humanity. (Ref.)
Although in the clinical studies they did not used Creatine, following these statements, I would clearly make sure that (maybe 30-60 minutes) prior to each MG administration there is a Creatine supplement administer too.
Source:
MG preparation:
Methylglyoxal can be bought from Western or Chinese chemical suppliers under CAS number 78-98-8. It is usually found as 40% Methylglyoxal in water solution. Here is an example of a supplier: https://www.scbt.com/datasheet-250394-methylglyoxal-solution.html
MG Clinics and Hospitals:
The Indian hospital from enclosed reference (Ref.) was still running clinical trials in May 2016. Patients can access MG at the following address in India: Lokmanya Medical Research Centre, Chinchwad, Pune 411 033
It seems that a Mexican clinic at Providence Pacific Hospital administered methylglyoxal to humans at the begging of 2000 but I can not find more info on that.
Methylglyoxal, also called pyruvaldehyde or 2-oxo-propanal (CH3-CO-CH=O or C3H4O2) is the aldehyde form of pyruvic acid.
Update on 21-June-2016:
Prof Koch’s formulation:
Yesterday, I was informed by a friend from Cancer Compass (thank you Jet) that various sources of information indicate that Dr. Koch shared his homeopathic data and formulas with a Dr. Eric Reinstorff in Germany (now deceased). But that Dr. Dieter Reinstorff in Hamburg, Germany (Eric’s son) is still manufacturing, distributing it, and using Koch’s homeopathic reagents.
Indeed, here is an interview (from 2005, in German) with Dr. Reinstorff referring to his work with Prof. Koch. As a result, he started up a small pharma company („REIKO“ Pharma Vertriebsgesellschaft GmbH, „REIKO“ comes from Reinstorff-Koch) owning 3 different products based on Koch’s formulations: Carbonylgruppen, Rhodizonsäure, Parabenzochinon. The products seems to be manufactured by Adjupharm GmbH in Germany while being advertised at the following website http://wulf-rabe.de/molekulartherapie.php. The products are available at most German pharmacies without prescription:
- Rhodizonsäure (10 vials costs 22 euro)
- Parabenzochinon (10 vials costs 22 euro)
- Carbonylgruppen comp. (10 vials costs 20 euro)
In USA, it seems that the above vials are available too but 10 vials would cost 300$ http://www.arrowheadhealthworks.com/KochTMT.htm
Patents:
In vivo assessment of toxicity and pharmacokinetics of methylglyoxal
A pharmaceutical composition and treatment method to reduce the proliferation of cancerous or tumor cells, in which the combined active agents are methylglyoxal, ascorbic acid, creatine and melatonin.
Oral formulation of methylglyoxal and its imino acid conjugates for human use https://www.google.com/patents/US20030087951
The invention relates to an oral formulation of methylglyoxal and/or its imino acid conjugates for human use and methods for preparing the compositions. Particularly, the invention relates to compositions comprising methylglyoxal and more particularly, imino acid conjugates of methylglyoxal. The present invention also relates to formulations of methylglyoxal and imino acid conjugates of methylglyoxal that can be used for the treatment and suppression of malignant diseases including but not limited to the cancers of Colon, Prostate, Pancreas, Lung, Oral cavity, Glioblastoma, and Leukemia.
Sustained release formulations containing methylglyoxal and their therapeutic applications https://www.google.com/patents/WO2015049689A1?cl=en
A novel nano drug composition for the treatment of cancer comprising 0.125-0.5 mg of methylglyoxal as conjugated to nanoparticles of chitosan, its derivatives, or other polymers; 25-100 mg of ascorbic acid; 75-300 mg of creatine; and 0.125-0.5mg of melatonin, wherein all constituents are meant for each kg of body weight.
Treatment of cancer by oxidation-reduction potentiation of cancerostatic dicarbonyls https://www.google.com/patents/US8163796
A novel treatment regimen is described for the control and elimination of cancer cell populations including cancer stem cells. The disclosed protocol consists of a pretreatment step followed by a treatment step. The pretreatment step sensitizes cancer cells to apoptosis by altering their intracellular oxidation-reduction state via reduced glutathione depletion. The treatment step involves the sequential administration of a cancerostatic dicarbonyl compound to induce apoptosis. The use of nanoparticle delivery systems further enhances both the pharmacokinetic and pharmacodynamic properties of the pretreatment compounds and the cancerostatic dicarbonyls. Since the pretreatment and treatment compounds are carefully selected and delivered, normal cells are not affected and side effects are kept to a minimum.
Reference:
Protein and nucleotide damage by glyoxal and methylglyoxal in physiological systems – role in ageing and disease http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2649415/
Glycation of proteins, nucleotides and basic phospholipids by glyoxal and methylglyoxal – physiological substrates of glyoxalase 1 – is potentially damaging to the proteome, genome and lipidome. Glyoxalase 1 suppresses glycation by these α-oxoaldehyde metabolites and thereby represents part of the enzymatic defence against glycation. Albert Szent-Gyorgyi pioneered and struggled to understand the physiological function of methylglyoxal and the glyoxalase system. We now appreciate glyoxalase 1 protects against dicarbonyl modifications of the proteome, genome and lipome. Latest research suggests there are functional modifications of this process – implying a role in cell signalling, ageing and disease.
Methylglyoxal enhances cisplatin-induced cytotoxicity by activating protein kinase Cdelta. http://www.ncbi.nlm.nih.gov/pubmed/11707430/
Importantly, co-treatment of cells with the reactive carbonyl MGO and cisplatin increased apoptosis by 90% over the expected additive effect of combined MGO and cisplatin treatment. This same synergism was also observed when ROS generation was examined. MGO and cisplatin increased PKCdelta activity by 4-fold
Effects of methylglyoxal and glyoxalase I inhibition on breast cancer cells proliferation, invasion, and apoptosis through modulation of MAPKs, MMP9, and Bcl-2. http://www.ncbi.nlm.nih.gov/pubmed/26618552
Collectively, these data indicate that MG or inhibition of GLOI induces anticancer effects in breast cancer cells and that these effects are potentiated by combination of the 2.
Triple negative tumors accumulate significantly less methylglyoxal specific adducts than other human breast cancer subtypes http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4170620/
Interestingly, the activity of glyoxalase 1 (Glo-1), an enzyme that detoxifies MG, was significantly higher in triple negative than in other subtype lesions, suggesting that these aggressive tumors are able to develop an efficient response against dicarbonyl stress. Using breast cancer cell lines, we substantiated these clinical observations by showing that, in contrast to triple positive, triple negative cells induced Glo-1 expression and activity in response to MG treatment.
Inactivation of glyceraldehyde-3-phosphate dehydrogenase of human malignant cells by methylglyoxal. http://www.ncbi.nlm.nih.gov/pubmed/9450641
The effect of methylglyoxal on the activity of glyceraldehyde-3-phosphate dehydrogenase (GA3PD) of several normal human tissues and benign and malignant tumors has been tested. Methylglyoxal inactivated GA3PD of all the malignant cells (47 samples) and the degree of inactivation was in the range of 25-90%, but it had no inhibitory effect on this enzyme from several normal cells (24 samples) and benign tumors (13 samples). When the effect of methylglyoxal on other two dehydrogenases namely glucose 6-phosphate dehydrogenase (G6PD) and L-lactic dehydrogenase (LDH) of similar cells was tested as controls it has been observed that methylglyoxal has some inactivating effect on G6PD of all the normal, benign and malignant samples tested, whereas, LDH remained completely unaffected. These studies indicate that the inactivating effect of methylglyoxal on GA3PD specifically of the malignant cells may be a common feature of all the malignant cells, and this phenomenon can be used as a simple and rapid device for the detection of malignancy.
Nanofabrication of methylglyoxal with chitosan biopolymer: a potential tool for enhancement of its anticancer effect. http://www.ncbi.nlm.nih.gov/pubmed/25999714
Fourier transform infrared spectroscopy revealed the presence of imine groups in Nano-MG due to conjugation of the amino group of chitosan and carbonyl group of MG with diameters of nanoparticles ranging from 50-100 nm. The zeta potential of Nano-MG was +21 mV and they contained approximately 100 μg of MG in 1 mL of solution. In vitro studies with Nano-MG showed higher cytotoxicity and enhanced rate of apoptosis in the HBL-100 cell line in comparison with bare MG, but no detrimental effect on normal mouse myoblast cell line C2C12 at the concerned doses. Studies with EAC cells also showed increased cell death of nearly 1.5 times. Nano-MG had similar cytotoxic effects on A549 cells. In vivo studies further demonstrated the efficacy of Nano-MG over bare MG and found them to be about 400 times more potent in EAC-bearing mice and nearly 80 times more effective in sarcoma-180-bearing mice. Administration of ascorbic acid and creatine during in vivo treatments augmented the anticancer effect of Nano-MG.
Glyceraldehyde-3-phosphate dehydrogenase: a promising target for molecular therapy in hepatocellular carcinoma. http://www.ncbi.nlm.nih.gov/pubmed/22964488
Hepatocellular carcinoma (HCC) is one of the most highly lethal malignancies ranking as the third leading-cause of cancer-related death worldwide. Although surgical resection and transplantation are effective curative therapies, very few patients qualify for such treatments due to the advanced stage of the disease at diagnosis. In this context, loco-regional therapies provide a viable therapeutic alternative with minimal systemic toxicity. However, as chemoresistance and tumor recurrence negatively impact the success of therapy resulting in poorer patient outcomes it is imperative to identify new molecular target(s) in cancer cells that could be effectively targeted by novel agents. Recent research has demonstrated that proliferation in HCC is associated with increased glucose metabolism. The glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase (GAPDH), a multifunctional protein primarily recognized for its role in glucose metabolism, has already been shown to affect the proliferative potential of cancer cells. In human HCC, the increased expression of GAPDH is invariably associated with enhanced glycolytic capacity facilitating tumor progression. Though it is not yet known whether GAPDH up-regulation contributes to tumorigenesis sensu stricto, emerging evidence points to the existence of a link between GAPDH up-regulation and the promotion of survival mechanisms in cancer cells as well as chemoresistance. The involvement of GAPDH in several hepatocarcinogenic mechanisms (e.g. viral hepatitis, metabolic alterations) and its sensitivity to a new class of prospective anticancer agents prompted us to review the current understanding of the therapeutic potential of targeting GAPDH in HCC.
Anti-Cancer Strategies of Methylglyoxal http://www.ijpr.in/Data/Archives/2015/july/2006201502.pdf
Methylglyoxal a simple carbonyl compound containing a reactive aldehyde and a ketonic group which stops the growth of cancer cells without poisoning normal cells. It is also called as Retine. These are very small molecules that are highly potent in controlling cell division. This compound inhibits the enzymes required for cancer cell and infected cell to grow by respiration and does not harm normal cells. As cancer cells require large amount of energy to multiply which was provided by ATP. Methylglyoxal inactivates the enzyme Glyceraldehyde-3-phosphate Dehydrogenase (GA3PD) needed for the ATP production in cancer cells and there by starves the cell to death and normal cells remain unaffected. As it is a carbonyl group, it inhibits the mitochondrial respiration followed by Glycolysis and Kreb’s cycle which play a major role in the production of ATP and supplies the energy to infected cell up to demand. It also play a role in binding of oxygen at cellular level and preventing the proteins to desaturate and inhibits the production of free radicals. Hence suitable energy and oxygen are unavailable to cancerous cell to grow, leading to death of the cell. It was believed that “If cancer cell cannot grow, it dies by itself”. It desaturate the proteins of malignant cell at cellular level by means of its ketoaldehyde group with an aminoacid of a protein causing the death of cell
The results clearly indicate that Nano-MG may constitute a promising tool in anticancer therapeutics in the near future.
Cancerostatic Action of Methylglyoxal http://science.sciencemag.org/content/160/3832/1140
Creatine supplementation with methylglyoxal: a potent therapy for cancer in experimental models. http://www.ncbi.nlm.nih.gov/pubmed/27138627
In conclusion, it may be stated that the anti-cancer effect of MG is enhanced by concomitant creatine supplementation, both in chemically transformed (by 3MC) muscle cells in vitro as well as in sarcoma animal model in vivo. These data strongly suggest that creatine supplementation may gain importance as a safe and effective supplement in therapeutic intervention with the anti-cancer agent MG.
Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity. http://www.ncbi.nlm.nih.gov/pubmed/18946510
The results described herein provide new insights into curcumin‘s biological activities as they indicate that inhibition of Glo1 by curcumin may result in non-tolerable levels of MGO and GSH, which, in turn, modulate various metabolic cellular pathways including depletion of cellular ATP and GSH content. This may account for curcumin‘s potency as an anti-inflammatory and anti-tumor agent. The findings support the use of curcumin as a potential therapeutic agent.
Curcumin inhibits advanced glycation end product-induced oxidative stress and inflammatory responses in endothelial cell damage via trapping methylglyoxal http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4732849/
Methylglyoxal (MGO) inhibits proliferation and induces cell death of human glioblastoma multiforme T98G and U87MG cells. http://www.ncbi.nlm.nih.gov/pubmed/27133062
We have also revealed that MGO induces senescence of U87MG but not T98G cells, but further studies are necessary in order to clarify and check mechanism of action of methylglyoxal and it Is a positive phenomenon for the treatment of GBM.
A novel mechanism of methylglyoxal cytotoxicity in prostate cancer cells. http://www.ncbi.nlm.nih.gov/pubmed/23333621
The results suggest that this physiological compound merits investigation as a potential chemo-preventive/-therapeutic agent, in differently aggressive prostate cancers.
Disclaimer:
This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.
Hello,
My mother just started methylglyoxal treatment 2 days ago for end stage Gall Bladdar cancer. We are giving MG 5mldose 4 times a day in 200ml of water. Other things that we are giving her is creatine powder, VitC tabs, B-complex, Curcumin. Now we are waiting for the drug to work.
Hi! Thanks for the comment! Can you please keep us up to date on how things are going?
Where do you get MG? From hospital in India or other sources?
Thanks.
From India, Daniel.
Momma Boy Did you order it yourselves?
Hi Cathy, I was recently informed that unfortunately Momma Boy’s mother passed away and did not had the chance to possibly be helped by MG … To my knowledge, the MG solution was received from a hospital in India. I mentioned the address of the hospital in the Source section of the above article. I think this is a hospital collaborating with Prof. Ray. Therefore, they are using exactly the same formulation and administration method I mentioned above (which was kindly confirmed by Prof. Ray via a private communication).
39% Complete remission ! , This sounds even better than Salinomycin !!!
I hope its hard for cancer to develop any resistant against it 🙂
Momma Boy , just like what Daniel said , keep us up to date
hope your mother will get better soon .
Yes, Emad, I agree 39% complete remission is impressive. If there would not be so serious history and science behind this molecule I would highly question it. But given all its history including the many Science publications of the Nobel prize winner on its anti cancer effects, next to all these trials on humans, I would say there is something wrong with our society … same society that is keeping 3BP on hold for 15 years now. And Salinomycin which is also so promising … there is nothing going on anymore with it in clinical trials … silence everywhere. I see a pattern here …
it is suspicious daniel, i think “they” don’t want cure to be cheap.
Hi Daniel, where would one go about acquiring this and what dose/administration of the product from the supplier would you suggest?
Thanks,
Meech
Hi Meech, nice to hear from you. My plan is above in terms of supplier, administration and dose. 🙂 Is there any other question?
Can’t believe I missed that section while reading the whole article.
Thanks Daniel; very helpful.
Hi Meech, I cam glad to hear on Cancer Compass you are doing well. I am sure you will keep it like that 😉
Thanks Daniel. Of course it will keep going
Daniel did you tried this treatment or not yet ?
and your experience about the MG from china , do you think its good just like the western versions ?
——————
keeping these kind of treatments on hold & away from the public are the biggest crime in history
thank you so much for sharing all this Daniel 🙂
Not tried yet Emad. Using Fred’s words, it depends on my VIP (very important patient) if she is willing to take it. I use a western supplier. I tried to speak with Prof Ray on the phone – we could not hear each other well but I think that Chinese sources may be used sometime in India. I also had a very nice discussion with an important drug producer in Germany who was saying that most of the worlds chemical products are coming from China these days. So I think the question is not anymore about the country of origin but about the quality of the supplier. Getting it from a supplier you trust in terms of quality is the key.
I do not think anyone is keeping them away – just that the solutions do not get enough attention since there is not a serious business behind.
Daniel
the tumor marker for my mother raised again from 460 to 560
I don’t know why ?
the same treatment that was successful last month , now failed !!!???
the other thing is, do you know about a trusted Chinese supplier for Methylglyoxal ??
@ Emad
What treatment She is undergoing now?
Hi Emad, I am sorry to hear that. What was the complete treatment? For myself I am buying it from western suppliers.
the tumor marker was 712
she started DCA + (5-FU & Vinorelbine) + (Hydroxychloroqiune 400mg & Lansoprazol 60mg)
after 3 weeks the markers became 670
after another cycle , 4 weeks , the markers became 460
now with the same treatment , the markers raised again to 560 !??
i didn’t hear about any cancer that developed a complete resistance against a treatment just in less than 3 weeks !!!!
is this thing happening normally ??
but there is a little difference in the last cycle :
1- she stopped taking DCA for 3 days before chemo (usually she is stopping DCA for 1 day only) , then she started with chemo
2- after another 8 days (after chemo) she started DCA with 25mg/kg for about 1 week (just like all the other cycles , but now she didn’t take Vitamin B1) , then I lowered the dose to 15mg/kg in the second week . (normally i am not lowering the dose that much)
but this is still a little difference to me , and that just changed the game !!????
i really can’t understand what is just happening , and my mother is losing faith from everything
sorry for my long comment Daniel , but what you suggest in this situation ?
do you have a good protocol (good combination of treatments) for us to use ?
thank you so much
Dear Emad,
Thank you for the details. First I would see the bright side, i.e. the markers are below the initial level and one data point (560) doesn’t have to define a trend. The other point I wanted to make is that from an ethical point of view, and in line with the disclaimers on my website, I can not advise you on what treatment protocol you should use. What I can do is to share with you, as I always do, my opinion and what I learn:
1. Small changes such as DCA can lead to large changes. If I remember correctly, you did took out DCA in the previous cycles and once you did that there was no response to Chemo. So far, I think there are good reasons to believe that DCA helps the effectiveness of Chemo in this case. As a result, if possible, I would get back on DCA at a similar dose and administration schedule as you use when the markers were in decline. Maybe even a bit higher dose? Or maybe also overlapping chemo?
2. As you know there are more ways to possibly increase the effectiveness of Chemo https://www.cancertreatmentsresearch.com/?cat=18 Increasing the Lanzoprazole dose several days before before and during the first days of Chemo may help too. Focusing on the inhibition of proton pumps during the same days will probably help.
3. As you also know, my personal believe is that if we chose to go for Chemo, options such as Salinomycin, Phlorizin, may strongly help if you could find a place to help with the administration. Please read the articles carefully https://www.cancertreatmentsresearch.com/?p=736. Maybe you can convince the oncologist to administrate Phlorizin during the chemo day in the same way they did it at the hospital in USA.
4. An alternative to Phlorizin to achieve ATP reduction in cancer cells during the chemo days may be 2DG https://www.cancertreatmentsresearch.com/?p=524
So there is so much we can do and I did not even discussed others such as MethylGlyoxal … you already know a lot Emad and you will find your way. Just spend some time to think about the above and if you have specific questions you can also send them to me by e-mail.
Thank you so much Daniel
and I understand very well that you can’t suggest or advice anyone to use anything , I agree with that
about DCA , my mother is feeling like numbness & burning in her legs , I’m am afraid of neuropathy , that’s why I lowered the dose but now I don’t know what to do with neuropathy is it okay to continue with it or what should I do
the other thing , we need to stop chemo as soon as possible , my mother is on chemo for 9 months , we need to change to another new protocol with strong treatments that doesn’t cause any bad side effects , MG will be the first , but even with a strong treatment like MG , I need to add more weapons to our arsenal
for example : how about this combination : MG + DCA + Mebendazol + Griseofulvin + Artemisinin
in your opinion is this is a strong protocol ? or still need to add more ??
sorry for my repeated long questions , God bless you for helping my mother
Dear Emad, thanks for understanding. You are helping your mother, not me, and she is very lucky to have such a son. I guess you know that one way to reduce neuropathy induced by DCA is to have on/off administrations, e.g. Monday to Friday on DCA and the weekend off.
The combination looks good but you do not want to ask me if is enough. I do not want to advise + I have the tendency to always add more in our case 🙂 You need to think for your case what is best but if would be for myself this is what I would have in mind:
– Clinics in Germany always add Cimetidine 800mg/day to reduce chance for metastasis.
– Metformin 1g/day is constantly suggested by e.g. prof. Dana Flavin due to its multiple anti cancer properties
– Lanzoprazole reduces acidity around the tumor but also helps DCA.
– If I would need to take something out of the combo you are considering, I would take out Griseofulvin as both Mebendazole and Griseofulvin are addressing similar mechanisms (same that Taxol is addressing). Offcourse together they may be stronger.
– I would not forget the natural options, specifically Omega 3 (fish oil or algae).
– Scute from iHerb contains Baicalein that may be highly relevant against breast cancer (city of hope in USA wanted to start a clinical trial on Baicalein for breast cancer).
– Off course supporting the organs is very important and on that line Astragalus and Silymarin are basics.
– Curcumin in high dose is also helpful.
Thank you for your big help Daniel
I will put all that in my mind 🙂
Dear Daniel, Can you help me out bro. My Mum is dying with Stage 4 GB cancer. Can you recommend some alternative drugs(in the link below) which She can take to halt tumour growth? Sorry if I sound desperate or stupid. 🙁 Onco has given her 2-3 months to live. 🙁
http://projects.propublica.org/graphics/cancer-drug-alternatives
Answering your question, I can not recommend what you should do but I can tell you what we use out of that list. We are using four out of those five elements. We use Cimetidine 800mg/day, Metformin 1000mg/day, Mebendazole 1000mg/day, Beta Blockers (Propranolol) 80mg/day.
Hi Daniel, I was prescribed beta blockers back in September because my surgery carried an extremely rare side effect (never before seen by my surgeons, or any neurologist/internist/oncologist) where nerve damage caused my body to be unable to regulate blood pressure and heart rate upon standing.
I decided to go off of the three pills they prescribed (Bisoprolol, Fludrocortisone, Midodrine) which they said I would potentially be on for the rest of my life and adopt a natural protocol of exercise to mitigate the effects – which has been a huge success.
Anyway, I was reading online about beta blockers + metformin and read that BB’s might lessen the impact of metformin. I can’t remember where I read this but have you heard anything similar?
HI Meech, thanks for your point. I will check further the research but based on the common knowledge it seems to be no interaction between the two http://reference.medscape.com/drug-interactionchecker?src=google. The only one out of this combo that interacts with most drugs is Cimetidine due to its impact on the hepatic enzymes. But we never had issues with this while we are using Cimetidine for nearly 3 years now. If in the mean time you find the reference please send it to me too. Thank you.
Momma boy what about MG ?
isn’t it effective ? how did you know that its not effective with your mother ?
the other thing is looking for a clinic but they will cost a lot 🙁
i hope your mother get better soon
I guess Momma boy just started with MG about a week ago, so it may be difficult to have an assessment so fast.
Daniel, from http://www.williamfkoch.com/web/version2/biography.php this Dr. Koch statement is interesting:
“… If the patient has been starved a long time because of cancer of the stomach, a large cancer, paradoxical as it is, is a benefit since, once killed, it supplies food elements and actually gives strength to the patient.”
Is this somehow beneficial TLS?
Also, he describes someone starved because of cancer of the stomach. This gets near to my wife’s condition as her ability to ingest food/water diminishes as weeks go by. While she may be able to take oral methylglyoxal at this time I must look forward to an alternate administration:
From Dr. Koch:
“… This substance when purified, taken up in water and immediately injected subcutaneously into a cancer patient, causes practically no local reaction; but instead, after about 24 hours, a very decided focal reaction takes place. Wherever the cancer tissue may be, its’ cells are killed, their ionic concentration increases, the osmotic pressure increases, they take up water, swell and disintegrate. The swelling causes pain and the absorbed, disintegrated products are oxidized causing fever.”
Since MG is water soluble is there an IV equivalent that is safe?
Interesting point about the stomach challenge, Fred. I am not aware of anyone trying an IV formulation. I will try to check with Prof. Ray and if I get anything will share here.
There was mention in Dr. Koch’s writings of intraperitoneal and subcutaneous injections with quick results. I wonder why current administration is oral.
Yes Fred, but that was OCCO not MG. I asked prof Ray if there is any knowledge regarding MG injection but didn’t get a response yet. Without any reference on human use, I would refrain from using it as an injection, even if from theoretical point of view would make sense.
Hello everyone, great work Daniel. I wonder how we can address methylglyoxal´s bad behavior of depleting good HDL cholesterol
http://www.science20.com/news_articles/sugar_substance_methylglyoxal_damages_good_hdl_cholesterol_study-143828 causing heart problems. Prof. Ray lost three patients of 46 due to heart attacks and two other ones for unclear reasons not related to cancer. http://www.cancer-therapy.org/CT/v4/B/HTML/17.%20Talukdar%20et%20al,%20205-222.html
Hi Paul, thank you. This is a great comment/question/addition! While I discussed in the safety paragraph potential side effects connected to the heart, I actually did not saw that pattern in the patients so your point is very valuable. According to that we can assume that while 78% of patients may benefit from MG treatment (39% complete remission and 39% partial remission or stable disease), about 10% may be lost due to heart failure.
If I would look from the risk perspective alone I would say 10% is too high. But if I think that the patients treated in Prof. Ray trial were late stage with no other option we could argue that MG saved 8 out of 10, 1 out of 10 was lost due to cancer and 1 out of 10 was lost due to MG?
Nevertheless, we should do our best to reduce the risks while maintaining or further increasing the chance of success.
I think the answer may be found in one of recent papers of prof Ray: http://www.sciencedirect.com/science/article/pii/S0008874913001901
Chitosan may be the solution, and it should be relatively easy to achieve that given that MG is water soluble.
In this way the MG dose can be very much reduced and it will be mainly targeted to the tumors + it will survive longer in the blood.
Liposome may be another option.
I will look into these options as soon as I find the time.
Maybe someone else reading this can find the time to look into these options sooner? That would be great.
I wrote this comment relatively fast as I have to go now but will come back to it as I think MG is one of the most relevant anti cancer elements.
I have to save my V.I.P. she has stage IV. unresectable mCRC. We managed it so well with artemisinin derivatives, curcumin, quercetin, EGCG, silymarin, GSE, boswelia, beta-glucan, lactoferrin,PQQ, NADH, NSAIDs , paracetamol, cimetidine, metformin, omeprazol, simvastatin and chemotherapy that all her metastases (7st) have disappeared in 14 month from liver, 70% from abdominal wall , primary tumor shrank by 80% so hospital decided to re-valuate her for HIPEC surgery. That is why she was put on hold in chemo for three months – her cancer just exploded – it is 2x 3x bigger than in the beginning. No more talk about surgery. MG could save her life but I’m kind of scared to use it as it is now. It would be great to find a kitchen table solution before it is too late. Research on nano-particles can take 5-10 more years before it is available for common people.
I am sorry to hear about the evolution and glad to hear that she has good potential for response. Maybe you could try TACE as well to stop the progression? Dr. Jason Williams is the best option in the US region and Prof. T. Vogl one of the best in Europe region. Have you considered that or that is no option? Based on what I have seen so far, I think Salinomycin, 3BP, Diflunisal are doing very good job. Beyond that, I have high expectations from all of the elements I am discussing in my posts and MG is one at the top of those. If I would use MG I would make sure I would indeed follow HDL in blood tests.
TACE does not seem to be an option in her case maybe SIR spheres in the future. The problem is that only about 40% of her tumors show up on PET CT so I need to investigate further Salinomycin, 3BP, Diflusinal. We started DCA a week ago but I’ve just discovered a dark side of it:
https://www.researchgate.net/publication/44663282_Sodium_dichloroacetate_DCA_reduces_apoptosis_in_colorectal_tumor_hypoxia
Thinking about turning hypoxic cells into normoxi ones to get easier rid of them. What do you think?
HI Paul, May I know what part of the tumor is highlighted by PET and which part not? Is a difference between the central part vs edge of the tumor? Or a difference between various spots?
It is difference between the spots. The largest one covering the womb is dark grey two others close to it are bright white and in the liver and around it is a mix of dark and bright spots.
Thanks Paul. I would make sure I would use a mix of treatment strategies that target both glycolisis and mitochondria. In my post I discussed such therapies, many of which are targeting glycolisis. Example of elements that are targeting mitochondria are: Metformin, Doxycicline, Salinomycin and https://www.cancertreatmentsresearch.com/?p=1129
Thank you Daniel. We are already using Metformin will check the rest if they are purchasable for a somewhat human price preferably in Europe. I stumbled upon this article about MG http://www.sciencedirect.com/science/article/pii/S092544391100072X difficult to interpret but it looks like that MG maybe is not suitable to treat colorectal cancer. What do you think?
Hi Paul, in theory Mg should be effective against any tumor type relying heavily on glycolisis.
Something interesting that I’ve found is that ketogenic diets can increase the amount of Methylglyoxal within the body naturally. It could add to why ketogenic diets have shown efficacy.
Hi Meech, that may be an important aspect in the ketogenic diet – we know so little and every day we learn more …
It is a little bit confusing the Japanese researchers stated that MG is a metabolism product from glucose in the body. So the more sugar you eat the more MG. http://www.sciencedirect.com/science/article/pii/S092544391100072X
Could it be so that cancer cells have difficulties to adopt to extreme levels of sugar both low and high? I have something in the back of my head about “Mountain Dew effect” from Cancer Compass, I think.
In short a guy was drinking a lot of Mountain Dew during his anti cancer treatment and got very good results if I remember well. Could it be the effect of MG or just sugar awakes sleeping cancer cells and this way they can be killed?
That is right Paul and the same is stated in my post above. So the more more glucose is consumed the more MG is produced. But in normal conditions cancer cells are able to get read of that by overexpressing GLO1 enzyme and GSH. (please see the Mechanism section). In theory, assuming you can inhibit GLO1 and or GSH effectively, it would make sense to increase the Glucose intake but in reality I would avoid sugar even if I think I can inhibit them effectively.
I remember a guy drinking Mountain Dew and getting DCA. If you are referring to that, it was DCA that was helping and I would not conclude much about MD based on a single case.
Hi Daniel,
I couldnt find the article about the guy drinking Mountain Dew and healed.
Can it be because of citric acid +DCA?
Hello Daniel
our friend Jcancom wrote this about MG :
———————
One thing to point out to you and others on the thread was that we had a slight trouble earlier with the dosing of MG. There was a substantial overdosing with it. Be careful not to confuse % by weight/volume for a molarity. I have no idea why they would label the way that they do.
Sigma’s 40% MG solution is not a molarity measurement
https://www.cancercompass.com/message-board/message/all,65701,360.htm
————————
so what is your opinion ?
the second thing , are you willing to try MG IV ?
we are about to receive our first MG and Salinomycin , I will love to administrate MG as IV if it’s safer and better
the last thing , the Vitamin C , should it be chewable ? not normal tablet or capsule ?
we have Liposomal vitamin C , I’m not sure if it will do the job
Yes, J is right, there were some mistakes in calculation during some discussions on Cancer Compass. The numbers above are verified with Prof Manju Ray. Nobody knows if MG IV is safer or better but it has been and it is applied on humans.
Chewable is what Prof Ray suggested.
Thank you so much Daniel 🙂
Hello Danielle, I am new to this. My husband is stage 4 colon cancer and it is progressing after Folfox, folfiri. Now his oncologist put him on Avastin and 5-FU. However, I do not have much faith. He ‘s been on cimetidine and metformin. I recently add Artemisinin. I would like to add MG but does he have to stop chemo or he can do these concurrently with chemo. I know you do not give advice but I appreciate your knowledge and I just need to know if people do these treatments alone or in combination with chemo.
Thank you so much.
Hanh
Also how can you buy from the supplier. I tried and they said they only sell to research facility or university.
Hanh
I just recognize that I misspell your name. I am really sorry but since the new of my husband’s cancer progression I could not think straight. Just the thought that he won’t be here for long is killing me. I’ve been crying so much for the last few days that makes reading so hard to understand and remember.
Again, my apology.
Hanh
Dear Hanh,
I am so sorry to hear about the challenges you are going through. Please do not apologize about the misspell – that is no problem off course. Also, please realize that the journey may be long so do not spend all your energy on one step of this journey.
Mebendazole, an over the counter drug, may also help http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825534/
Regarding your question: people across the world find their own way to get MG either through friend in Universities or various other ways including from Chinese suppliers on Alibaba. As mentioned above, best way seems to be to get it through the Indian hospital (see address above) who seems to help patients from outside India too.
From a mechanism point of view, I would expect that MG will help chemo but best is to contact the Indian hospital and check with them.
Beyond that, I believe that chemo effectiveness may be enabled or increased by addressing various relevant resistance pathways such as those discussed here: https://www.cancertreatmentsresearch.com/?p=970
Some way to possibly improve chemo are very simple (such as drinking a coffee before the IVs, taking some Paracetamol) and other would require some drugs that you may discuss with the oncologist and ask if he/she could help.
I hope this helps and answers your questions Hanh.
Al the best to you and your husband!
Kind regards,
Daniel
Hello Daniel, I saw that you use Propranolol for your wife. I asked my husband’s oncologist for that and she said my husband does not have high blood pressure so there a danger that his blood pressure may go too low if use that? My husband also has high cholesterol, high triglyceride problem, I wonder if MG will pose more risk? Thank you.
For Paul, my husband only had liver mets. We decided on SIRT treatment. After that his cancer explodes in the liver, go to lymph node, peritoneal . I am so sorry that we did Y90 since it did not help him but makes him sicker. For some it may help but in our case it did not.
Hanh
Propranolol may indeed be risky if the blood pressure and heart rate is already on the low side. For my wife is perfect since the parameters are on the high side but for those like me with a slow heart it may even be lethal? Is great you are consulting your doctor on this one!
For liver (but other locations too) to address on short term important challenges, TACE (trans arterial chemo embolisation) seems one of the best. You can have TACE options both in US (dr. Jason Williams) and in Europe (prof Vogl, Frankfurt University). It works for many at least to temporarily stop the growth.
Are the methylglyoxal and koch treatments designed to be used separately or simultaneously?
There is nowhere an indication on that Mike. My opinion: first Koch and if no response MG
I have researched and studied methylglyoxal as a cancerostatic agent for 40 years. Dr. Szent-Gyorgyi, with whom I occasionally corresponded in the 70’s and 80’s, was an incredible visionary. He recognized the uniqueness of methylglyoxal and how it could quite selectively kill cancer cells while not harming normal cells at millimolar concentrations. However, he also understood the challenge of delivering a pharmaceutically active concentration to the tumor site in the face of the high glyoxalase I enzyme levels in cancer cells. Interest in methylglyoxal as a cancer treatment has increased in the past 20 years. People have looked at ways to inhibit glyoxalase I activity with specific inhibitors as well as protect methylglyoxal prior to delivery to the cancer site with nanoparticles and more recently Dr. Ray with chitosan. I have tried to encapsulate methylglyoxal with 60-100nm particles unsuccessfully. While some of these approaches have been successful in increasing methylglyoxal effectiveness their still not good enough leaving 20% viability and perhaps inducing drug resistance. As far as IV delivery, methylglyoxal is very acidic, even when diluted with pH typically 5.5 or less. Adjusting the pH up tips the equilibrium from the active keto form to the hydrates. My approach which will be tested shortly(this year) regulates the cancer cell redox state making the treatment with methylglyoxal far more efficacious ( 0% viability) @ 100micromolar. I hope this sheds some additional light on the discussion.
Dear Dr. Michael,
Thank you for your very helpful contribution.
I understand that your approach refers to an IV formulation. I have three questions related to that:
1. Can you please let us know what is the effective MG dose expected to be required in your formulations? Is it lower than that discussed above?
2. Can you please let us know if the test you are going to perform are on humans, and if that is the case what will be the context? Can anyone apply for that?
3. What is your opinion on the potential of MG toxicity related to the heart?
Thanks in advance.
Kind regards,
Daniel
Dear Daniel:
1. I am looking at MG doses that would be 20-50% of Dr. Ray’s. When administered orally, Dr. Ray typically gives 30mg/kg body weight /day.
2. Testing initially will not be on humans. However the test system is very new, innovative and quick turn times. Initial testing will be done on triple negative breast cancer cells due to the current lack of success for standard therapies.
3. I don’t have a strong opinion on heart related methylglyoxal toxicity.
Dear Dr. Michael,
Thank you for your response. When the product becomes available to humans please let us know.
Kind regards
Hello Daniel
hope you and your wife are doing good 🙂
I like to share a little bit about what happened last 2 months
the tumor marker was 939 , but when we test again it was 712 not 939
and it raised from 450 to 712 because of stopping both chemo and DCA
the oncologist decided to change to another chemo : (carboplatin + gemzar)
because of neuropathy I didn’t try DCA orally
after 3 weeks on chemo only , there was a very little decline in tumor marker , from 712 to 685
then after my mother felt good (less neuropathy) I decided to give her DCA again , but now I started on IV’s
but I started with low doses and raise gradually , 1 or 2 IVs per week , 45mg/KG
after 3 weeks (chemo + low dose DCA) the tumor marker raised to 699 !!!
I felt so bad that time and confused , but I thought maybe it is still early for DCA to work !?
or maybe the cancer became resistant to both DCA and Chemo together !!?
I started to give my mother higher doses of DCA
2 to 3 times per week , 70mg/KG each IV
after 3 weeks (today) the result is : tumor marker declined from 699 to 517
I was so happy that the DCA and Chemo combination are still working , and the good thing about that is the side effects are very low with DCA IV , there is neuropathy but not as bad as when taking DCA orally
and the other thing , this chemo drug (carboplatin + gemzar) have a little side effects on my mother
———–
I shouldn’t forget , finally Methylglyoxal and Salinomycin arrived to Libya
tomorrow we gonna receive them , and I also have creatine and chewable vitamin C
but I’m not sure how to start with it , should I combine MG with DCA and Chemo ? or should cancel DCA ? or maybe keep them all and just raise MG doses gradually ?
I’m not sure what to do
and regarding Salinomycin , I don’t have Kolliphor , Sigma are not responding at all
I could not find Kolliphor anywhere other than Sigma , and the only choices I have is ethanol or DMSO
I don’t know if its okay to use one of them , but maybe it’s better than just waiting …
that’s all my story to now , thank you so much
my best wishes for you and all the other fighters around the world 🙂
Dear Emad, nice to hear from you and thank you for the details. Is good to hear that the markers are going down at higher DCA dose. I think you are now in the dose range that was used by Medicore. This reminds me that I still have to write a post on DCA …
If it would be for myself, I would give priority to Sal in combination with Chemo over MG. That maybe just my bias, but that is a strong bias. If you have the cheap version of Sal you may do some experiments with it by mixing with etanol or DMSO and after that push in saline. To my knowledge that would precipitate and the particles that are created can be larger than 25um which is the pore size of the standard filter that is mounted on every IV set. That means that all of the Sal will be stuck in the filter and nothing will go through in the blood.
I have some tricks that may help reduce the precipitation even without but best is Kolliphor. If that is not available than one could also think of using just a bit of Paclitaxel solution if that is available. Normally, Paclitaxel is available everywhere and using just 0.5ml of that should only contain a very very little dose of Paclitaxel and the rest (about half) should be a Kolliphor-like substance (I think castor oil). I never used this approach but it was just an idea I had before getting to Kolliphor.
I know you are a medical student but I hope you have a medical doctor that helps you with the above.
Like I said before, as long as it works and there are no serious side effects why would you stop DCA?
All the best EMAD and please keep us up to date with the evolution, and I hope to hear only good news!
Thank you so much Daniel for your great help
like what you are always saying , we should balance the risks
I will not run out of DCA and will not stop it , it’s working and I will continue using it
and there is no hope from sigma right now , so the only solutions I have now is :
1- using MG with the risk of interfering with DCA
2- using Sal with the risk of mis preparing it (or using castor oil for preparing IVs)
I will choose number 2 , everything is welcome except cancer
and no more waiting , I will go straightforward , I will be responsible for what will happen , and always thanks for your help 🙂
I will keep sharing all the time …
Emad, I always make small steps when stepping into unknown. That is to minimize risks. So I hope that going straightforward also means small steps at first. Can you please share here (or by e-mail) how you are going to go forward with Salinomycin usage? But please share every step in terms of formulation and administration like you would do it right now. Thank you.
I will be happy to share what i will do , i was planning to share this with you before doing it
1- i have a castor oil that is used for medical purposes , used for taking it orally (not externally or parentally) and not the jelly version that is used especially for constipation, (it looks clear and liquid), bought it from a good pharmacy (maybe good)
2- i will let my mother take some of it orally , just in case , it should be fine
3- after 1 week from administrating chemo , when my mother feels good , i will inject 0.5 ml to the 250ml NaCl (using the sterile filter) without Salinomycin
4- if things go well , i will try again 1 or 2ml castor oil injecting it to 250ml NaCl , no Salinomycin
5- if things go well for 3 days , i will mix 0.5 ml paclitaxel with 0.5 ml castor oil , and also Salinomycin 9mg , my mother weighing 75KG , this means: the dose will be 0.12mg/KG , and also in 500ml NaCl administrate it for 2 hours at least
6- if things go well , after several days i will inject the other 16mg i have left , this means 0.213mg/KG
and then hope to get the desired effect , i don’t know if what i will do is enough to solubilize Salinomycin (this is challenging)
and also , it took 2 weeks for Sal to arrive , I’m not sure if its okay for letting Sal warm that time , its stored in the freezer right not for sure
————–
that’s what I’m planning to do , and i think there is some other things I’m missing , you mentioned some drugs that may protect from neuropathy induced by Sal, and maybe there is other things i should take care of before going straightforward
i remember the first time using DCA IV , i used just 0.5g at the very beginning 🙂
hope there is no big mistakes about what I’m planning to do 😀
Emad, I will send you an e-mail with my comment.
its stored in the freezer right not for sure
i meant : its stored in the freezer right not for sure
(mistype)
its stored in the freezer right NOW for sure
i keep typing it wrong , my mistake
As you maybe already read about our case we have a lot of issues with liver due to unsuccesful SIRT treatment.
I was planning to use methylglyoxal – but then I found this http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4206746/ .
Any advice?
Hello. I hope you can help me with your advice. A 75 year old relative of mine has been diagnosed with stage 2 non-Hodgkin lymphoma of the stomach and pelvis. He’s also had Parkinson’s disease since 2010, and two bypass operations of the heart. I’m thinking about getting him on the Koch program of:
Rhodizonsäure, Parabenzochinon and Carbonylgruppen from Adjupharm. Do you think that is a good idea? Can he take these together with medication he’s taking now? Do you have any other suggestions maybe?
Thank you
Hi, I intend to try the Adjupharm products myself too. While it is not known what could be the interaction of these with other medications, I do not expect any issue since they are homeopathic products. For other ideas, just go through my post. Due to the angle I am taking when looking at cancer, most treatment options I am investigating and sharing here are relevant for most types of cancers.
Hello Daniel, I read the translation of the Koch therapy but I am not sure if I get it correctly. Would you please tell me how to alternate between the ampules. You only mention Rhodizonsaure and Carbonylgruppen. How about Parabenzochinon.
Thank for your help.
Hanh
Hi Friends,
I wonder if any of our friends is now on MG or tried it before?
I want to begin MG as soon as possible with your experiences if you have.
Do you have any idea where to buy it.?
From buying Sigma is very hard because it takes 6 weeks.
I have found this article about the toxicity about MG.I liked it.%80 of animals cured.
http://www.sciencedirect.com/science/article/pii/S0041008X0500400X
Kind Regards
Ergin
Hi Ergin,
MG is also available at Santa Cruz and other chem suppliers. The hospital in India mentioned above is also give it to cancer patients. You can try to contact them.
I hope your mom is better.
Kind regards,
Daniel
Dear Daniel,
Again thank you for your kind responds.Sorry for too many questions.
I hope chemo will work.I am thinking for surgery too much these days.But if chemo will not work?a surgery with hopeless.
I took too much responsibility and went to a wrong doctor,it makes me very very sad in each day.
We choose the wrong way,we must go to surgery when ca125 declined to 5 after first 3 cycles of chemo.
Thinking of salinomycin but i couldnt find a dr to use it.
But we will try all posibilities and find a way to chemo work again.
I believe this.
Kind Regards
Ergin
Great. wasted a full hour typing here……. only to get a message saying i am trying to spam ffssssssssss
Please someone contact me.
I want to get and share information/experience.
I prefer skype for this.
Got some stuff here with Graviola, Paw Paw, Aspirin, CBD, Ginger.
And many more. if only my comment wouldn’t have been canceled by the spam filter. i would have shared it all here.
Please contact me.
May you have good health and fortune.
Snake
I am sorry for that. Indeed, there is a spam filter that is running in the background, filtering out comments that are somehow standing out and probably that includes very long comments or comments that include links that may be detected as suspicions. If I take it out, I will get hundreds of spams every day … You can send me anything by e-mail (see the contact page) and will find a way to post that e.g. as part of your comment. Thank you for your understanding.
Anyone with experience on Paw Paw, Graviola?
Anyone tried aspirin?
I’m getting some good results with them.
Also, CBD oil and Ginger amongs others
I’m looking to exchange experience and information.
Please contact me, read the above post.
Dear, from your comments above I feel you are trying to get attention, get contacts on private and take advantage of people in need (possibly CBD). As a result, I removed your e-mail address from your comment above. If you have something to share please do that here.
It’s not what i am trying. I am trying to obtain and share experience in order to save my mom’s life.
I do not want to get or make any money off of anyone. I have no such scheme or plan.
I am sorry to hear about your mom. I hope you will find a way to help her, and I hope the info shared by others on this website helps in some way. Regarding your previous comments, I think it is fair for all if we use this website not only to read and to connect with others on private but also to share with all what you have learned. Thanks for understanding.
This method suggested by you here is quite slow i feel.
So far nobody said anything in reply to my comments.
I did replied. But just to be more specific, I do have experience with all those you mentioned above, both personal experience, that from others and literature study. I am specifically positive about Aspirin and related compounds (e.g. Diflunisal, Salicinium), but also about CBD. Ginger is relevant, specifically in the IV form. Graviola and PawPaw are also interesting but from a different category, i.e. soft. Not for advanced cancers. Please let me know what is your experience with them.
We started with cbd oil, did not to much.
Added aspirin 100mg/kg after a good 2 weeks of cbd and artemisinin plant capsules
Aspirin+CBD oil were a fresh breath of air. It stopped pain very good and urin may have been showing some lysing
stopped artemisinin
Was good till bleedings started.
Added graviola tea about 5g tea infusion for 75/kg, was good but much beter after stopping aspirin
Replaced graviola tea with paw paw capsules and then added graviola tea on top 1 cup troughout the day instead of 3.
We go with things at 6 hour intervals 3 times a day
It’s been about 2 weeks since starting on graviola/paw paw
after drinking graviola tea, itching, tingling sensastions occured in the areas where the problems are, everyone i talked to said that may be due to healing.
paw paw / cbd oil / ginger / every 6 hours 3 times a day and graviola on top over the day is what we are using now.
urin coloring is strong and foam
almost No pain compared to extreme pain
Almost normal mobility
Normal apetite now
Almost normal sleep
lymph node on arm still noticeable and palpable
There are many things to be said, that’s why i would like a faster method.
Things have been getting better and better each day.
I am dealing with adenocarcinoma of the lung after a surgery that has spread. It’s been about 3 months since surgery
No chemo/radiation at all.
Let me know
Best wishes.
Thank you for sharing! If anyone will want to contact you on private, I will give him/her your e-mail address.
When are you going to perform the next scan? Or are there positive changes in the blood results?
Improvement of mobility, appetite and sleep sounds great.
100mg/kg aspirin sounds like too much … was that given IV? At that dose there are also high risks of bleeding.
How much cbd oil, paw paw and ginger are you using?
Inhalation of various compounds (including tea?) is a relevant approach when tumors are in the lungs.
You mentioned that it has spread, before using the above. Is there another location, other than the lungs?
Kind regards,
Daniel
Getting first blood tests results tomorrow.
Everything was given by mouth, not IV. – We had bleedings as i mentioned.
Our oil mentions something like 90% extra-virgin hemp oil and 10% CBD. 35 drops on each dose after aspirin, in this case now, after Paw Paw.
Ordering of treatment elements is an important part of synergistic efects i feel.
Paw Paw capsules, currently we are getting 2 capsules/3times a day – as suggested by the company that makes them.
No inhalation, we did frankincense oil inhalation and ingestion, kinda useless.
Surgery was a mistake for too many reasons, our experience demands everyone to think before making this choice.
Besides missing part of the lung, the problem didn’t go, even more… it has helped it spread and the body only got weaker due to the surgery and the effect of a damaged lung etc.
I would love your opinion on various things.
Maybe skype?
If not drop it here.
Just got CEA level today, 28.5. i’m quite certain it was higher before but i have no test to confirm it.
Any opinion?
Hi, if you like to discuss on skype please send me an e-mail with your ID and we can try to find a time during the next week.
Kind regards,
Daniel
What about adding beta glucan and vitamin d?
Both are very good in my view. Just monitor from time to time Vit D levels in the blood.
I hope you found our discussion on Skype helpful.
Kind regards,
Daniel
Doing 10g/graviola leaf powder infusion (tea) every 4 hours
2 paw paw capsules 3 times a day
about 30 drops of the oil mentioned bellow *** on ocasion now.
wondering what else to add on top of this protocol
Available things:
– artemisinin
-hemp 90% cbd 10% oil ***
-betadine
-Aspirin
-Vitamin D
-COD liver oil
-Flax seed oil
-olive oil
-coconut oil
-Vitamin C
-Curcumin
-Ginger
-Appricot kernels
-nistatin
-iv vitamin C
-multi vitamin from organic source
-Propolis
-pumpkin seeds
some more medicine…… a full bag of tricks.
i don’t wanna brag or complain but my room smells greenish – funny ha?
I want to get the most out of what i have around for now.
I’m fairly convinced that it’s not just items in the protocol that contribute to healing but also a good strategy based on science and personal experience.
SO… here to learn.
got some people suggesting and promoting the following as “the cure”:
black seed oil
salvestrol/resveratrol
I’m quite sceptical tho.
Looking forward for anyone’s opinion or reaction.
Thank you very much Daniel!!!
Hi Alex,
Out of those you mentioned above I find the most relevant Artemisia Annua (as discussed), Vitamin D, Flax seed oil, Curcumin, iv Vit C, Propolis (but in high dose and if possible from Manuca), Black Seed Oil.
Kind regards,
Daniel
Thank you very much Daniel.
What would work best with Graviola / Paw Paw from the ones you find most relevant?
Combinations, oder of administration and dosages.
If possible include desired effects of each element chosen from the above for the Graviola/Paw Paw protocol
Please if possible, have a look at this page: http://alternativecancer.us/pawpaw.htm
You may already be aware of that page but just making sure.
In the lower part of that page there is a compatibility section mentioning quite a few things.
What is your opinion about what is said in there? This may be valuable information for me and my mother but also for readers of these comments.
I do hope i am not asking for too much information here. And thus too much time from you.
Anything you may dispense will be most apreciated as you would probably guess.
Many thanks
Best Wishes!
Snake
Dear Alex,
In order to be able to think of a strategy around pawpaw I would have to first check the mechanism that is claimed to be behind pawpaw and also see if that is supported by enough scientific literature. It will take some time until I find the time to look back into pawpaw. As soon as I find the time to look into it I will let you know.
However, please note that the subjects of the articles I shared so far on this website are focused on anti cancer elements that are in my view more relevant, and I suggest that in the mean time, until I can respond your question, you go through the articles and see what else you could find relevant other than pawpaw.
Kind regards,
Daniel
Bad news i guess, got the CEA values after 20 days interval by phone call, can’t be sure of the exact number.mom said somehting like 43 and then some. last value was 28.05.
We’ve been pumping graviola leaf powder tea and paw paw every 4 hours about 4 times a day for the tea and 3 times a day 2 capsules of paw paw.
Either it’s something we are missing, products may not be of sufficient quality, mom’s situation is “special” or the whole graviola/ paw paw thing is just another scheeme on the internet
We dropped this protocol to go back to aspirin, going to do enemas and anti-oxidants at least for a few days till we get a more clear path.
I don’t know who or what to believe anymore…………. contradictions everywhere.
Incredible to see that by this year nobody seems to know anything about this common medical issue, and even when someone knows something, someone else will contradict it.
We need help……………
I know you are very busy dear Daniel. Please find a little bit of time for me and my mom.
Meanwhile watching scam artists getting ritcher off of desperate people on the internet and becoming faimous for it.
Makes me realize this website is a treasure amongst all the crap out there.
thinking of opening a campain on gofundme
this cancer problem is a very tough one on many facets, as you all know.
Sorry if my reply is too long.
All my best wishes and respect to everyone reading this.
Love you all.
Alex
Dear Alex,
I am very sorry to hear about the markers. Paw paw indeed seems to have some relevant anti cancer components inside, e.g. https://www.ncbi.nlm.nih.gov/pubmed/18598079, but as you are saying, the tumor type, tumor location, the quality of the product you are using, different bio availability and pharmacodynamics in different patients can all have own contribution to the outcome.
What is clear to me is that you did your best using Pawpaw and for your case that seems not to help. So it is good to switch to something else. What are the treatments you are now considering? Take care with the aspirin as you know too much of that may lead to internal bleeding.
Please let me know how I can help. Best would probably be to let us know here what is that you intend to do as next steps and people, including myself, can react and give you ideas on that line.
To my knowledge, the gofundme campaigns are very useful to ask the help from those people that already know you unless you also use FB and other tools to reach more people.
All the best to you and your dear mom, and just let us know here how we can help.
Please also see below the very helpful comment of Helga.
Kind regards,
Daniel
Hi Alex,
One other idea is to explain the story of your mom in details including tumor type and evolution, current tumor status, previous conventional and alternative treatments, current treatments and what you are planning in terms of treatments. This I can publish in the same way as I did for Ergin here https://www.cancertreatmentsresearch.com/?p=2027 and people can react and give you ideas. If you like that, please prepare a clear story on the points I mentioned above, send that to me by e-mail and I will publish it as soon as I receive it. What do you think?
Kind regards,
Daniel
D, I came across this way to boost chitosan nanoparticles.
This might be a way to boost up NanoMG. PMID: 27375786
I am also wondering about the vitamin C dose that is recommended in combination with MG.
400 mg of oral vitamin C seems to be hopelessly to small a dose.
I wonder how high dose iv Vitamin C might combine with MG especially iv NanoMG.
Perhaps 100 gram iv Vitamin C over 2 hours and then 10 grams per hour for 10 hours.
One needs to be careful as changing the vitamin C dose might add safety concerns, though it would be interesting to hear what the MG experts thought of this.
Dear Alex,
I have read your story, sorry to hear that your mom is not doing so well. I agree, surgery may not be the best option for a metastasized tumor. The reason is that the tumor itself secretes anticancer proteins to suppress the growth of the other tumors. They were isolated by Judah Folkman in 1999. Once the main tumor is removed, this inhibitory effect goes with it and metastatic tumors will grow more easily.
Anyway, regarding your treatments are not sufficient I think. Paw-paw was proven to arrest growth by preventing fuel from food to reach the tumors. So it is good to take around meals I think.
Have you tried to inhale Lapacho tea? It can be quite effective against lung ailments. And also, would you consider citric acid? As your mom has not received chemo yet, it might work esp. well for her. I am taking now 12 grams per day in 6 doses. I feel that it is important to spread it out during the day (I suspect I have ovarian cancer). It makes me feel so much better, amazing. But it is important to keep the body alkalinized. There is tremendous valuable information on Daniel’s site in general and also on citric acid. I myself wrote about an article written in 1866 (!) about the use of CA to treat cancer in a respectable medical journal. I am not sure if CA interferes with paw paw, you could always do some internet search yourself.
Also enzyme therapy is great for cancer. If your mom’s heart is strong, you could try oleander treatment. If you are cash strapped, you could make your own, although Ergin is against it. But if you follow the instructions closely, it is safe. I myself cooked it once and then used to take it. The important thing is to filter the “tea” twice, very carefully, to make sure that no pieces of the leaves are left in the final product. It is described somewhere how to make it exactly.
Beta glucan is great plus you might consider cimetidine. Also, if she can tolerate heat, an infrasauna would be a good idea. Best thing would be for you to read this site carefully, it is a treasure trove of useful information! And I have come across hundreds of sites about “alternative” treatments of cancer. Daniel’s site uniquely combines the best of both worlds. Just read his articles.
Kind regards,
Helga
hi helga
can you provide the recipe for oleander? as i m trying to find a prepared one,but no luck until today
thanks
hi,
this is the site I used: http://www.tbyil.com/oleandersoup.htm
The filtering using 4 coffee filters etc are the most important part, you must observe it. What cancer do you deal with, may I ask?
Dear friends,
First of all Thank You!!!
For reading, for tyring to help.
I don’t even know where to start from. It’s going to be a long one, sorry!
Markers almost doubled in 20 days of paw paw / graviola treatment
We did aspirin / CBD oil before for a couple of weeks, and that seemed to work better, no numbers to prove it but the CEA level was 28.05 just about week after switching to graviola
Now the CEA level is 43+, no exact number yet, Also CA 19-9 dropped a few points from what i heard. They were bellow the refrence value in the begining and now even lower….
It’s funny because since her pain was gone this entire time, we were expecting a drop. Apparently pain absence may not be an indicative of healing.
I am wondering weather the CEA levels are higher because of other crazy reasons such as tumour necrosis, some liver problems etc……….???????
This is when i wish i had a CT scan room next to my bedroom. Or something way better Star Trek technology, something….
It’s amaizing how little has been done in this quest compared to other problems such as, how to get a better duck lips selfie.
Today’s transistors are small enough for maybe 100 of them to be fitted with ease inside a human red blood cell if not more.
We search and find other planets that we will probably never ever reach while here we still search for solutions to some of the oldest problems in the entire known history of earth and humanity.
Everything seems so uncertain and unclear now, how do we measure anything in this world with more accuracy and certainty?
Confusion, desperation, no clear path and broken.
I am now financially stuck, only managed to pay for basic food and some bills.
I gave all my money that i had saved for a brighter future to this cause, and i don’t see the light.
I feel i have talent, ambition and tenacity to help my mother, but i need experience. Certainty and guidance.
I am feeling the ground going away from my feet as time goes, i had very high hopes in the Graviola/Paw Paw protocol since soooo many state they got well.
I don’t know how much time we have left to experiment with treatments, i need a clear certain solution that will work for sure.
I may be asking for too much, being broke, unable to do more testing, gene sequencing, more blood tests, urine etc.
I hate to leave my results to chance, but it looks like i have no choice, forced by the laws of the universe, i don’t know anymore.
Not here to complain, i realize everyone must be going trough similar issues and emotions.
So after hearing about this level of CEA, we decided to halt treatment and revisit the options.
Went ahead and told my mom to drink ginger + lemon tea, high concentrations.
Gave her a few aspirins and cbd oil, she started feeling better, no more pain, just a sense of inflamation in the area where the primary tumour was/is (spine), some burning sensations in her right breast, lymph nodes seem more proeminent on her arm.
Some stabbing pain as Ergin described with his mom.
We just did a saline wash, then a coffee enema in the evening.
Laying the foundations for a new treatment strategy begining with detox, if any is strongly suggested based on personal experience.
Please let me know what is actually working for you.
I kept looking again and again on budwick, gherson. IDK anymore what to believe…..
For some it worked maybe, for others it didn’t. What to do from here?
I am thinking about beta glucan and maybe some other things if i can find the money to bring them over from another country.
Things that Daniel suggested.
Even if i had all the possible solutions materialized before me for free. I would still be confronted with the problem of choice since time in these situations is a big problem i feel.
Helga dear, inhalation is probably next to useless in our situation since the main tumour was partially removed with the upper right part of the lung, leaving small parts embedded into her spine. (that was then) Oct 2016.
Citric acid??? did not try. Only some lemon juice. Please more information needed.
If you believe you have some cancer of sorts, i think you should go check it out with contrast substance, scanners are bad for you but knowing something for certain is very important i believe.
What about ensyme therapy? Oleander? Any certaininty? My mom has heart problems that are worse now with part of the lung missing after a extreme surgerry. Oh how wrong we were…… what a mistake, just after surgerry we said, HELL NO to the rest of the “treatment”
Compared to anyone else i know that has cancer, my mom is feeling better than some “healthy” people her age without “treatment”
She can not tolerate heat sadly, cancer doesn’t come to the healthy ones. All those kids who have cancer either have their genetics wrong or their diet change could fix it and then you would see them getting their websites, asking for hundreds of dollars to tell you their secret, healthy food! OMG the industry is keeping it secret from us.
I get nudged from left and right by people who claim miracle results from RESVERATROL and Black Seed OIL
After trying a few miracle “pills”, i can safely say…….. i’m tiered of Snake oil.
People call me Snake, i think i should get some aparatus and make / sell oil myself. It will be branded so you know it’s the original that can CURE you for sure.
Anyway, our experience points to aspiring + cbd oil as being AWESOME.
Alone? nope….
With the only problem beying the bleeding, I am pondering mixing it with vitamin K to reduce that side effect as Al was talking about on another page here.
Any opinion is welcomed.
What about Rigvir??? They seem confused too. No guarantees, no repetable precision results. This doesn’t look like science anymore.
Everyone charges what you never had your entire life. Everything is so expensive and the problem is so common. So paradoxal.
I’ve been reading here, almost everything is written with inhibited emotions behind the keyboard.
I know you all suffer so much, just as i am. We fight, more or less together to save our loved ones or ourselfs.
I didn’t cry much till i saw how many more are suffering, and seeing some fighters here keeps me a little more encouraged, with some sholder to cry on that understands my pain of seeing my mother seeking help in my eyes with her gaze.
This diagnostic “cancer” is the worst of all emotionaly because of no known actual cure for all of them, pointing to either a lack of understanding, application of knoledge and science, science itsef missing…. something is not right.
Personalization of treatment is TRUMP expensive. Society still values money more than life.
Please advise.
If anyone else is interested in talking, i’m almost always available on skype. Snake_Systems
Daniel please, if any time available. Do login.
All my best wishes to you all, may good health and happyness be with you!
Alex
not again….. this comment approval thing.
Dear friends,
First of all Thank You!!!
For reading, for tyring to help.
I don’t even know where to start from. It’s going to be a long one, sorry!
Markers almost doubled in 20 days of paw paw / graviola treatment
We did aspirin / CBD oil before for a couple of weeks, and that seemed to work better, no numbers to prove it but the CEA level was 28.05 just about week after switching to graviola
Now the CEA level is 43+, no exact number yet, Also CA 19-9 dropped a few points from what i heard. They were bellow the refrence value in the begining and now even lower….
It’s funny because since her pain was gone this entire time, we were expecting a drop. Apparently pain absence may not be an indicative of healing.
I am wondering weather the CEA levels are higher because of other crazy reasons such as tumour necrosis, some liver problems etc……….???????
This is when i wish i had a CT scan room next to my bedroom. Or something way better Star Trek technology, something….
It’s amaizing how little has been done in this quest compared to other problems such as, how to get a better duck lips selfie.
Today’s transistors are small enough for maybe 100 of them to be fitted with ease inside a human red blood cell if not more.
We search and find other planets that we will probably never ever reach while here we still search for solutions to some of the oldest problems in the entire known history of earth and humanity.
Everything seems so uncertain and unclear now, how do we measure anything in this world with more accuracy and certainty?
Confusion, desperation, no clear path and broken.
I am now financially stuck, only managed to pay for basic food and some bills.
I gave all my money that i had saved for a brighter future to this cause, and i don’t see the light.
I feel i have talent, ambition and tenacity to help my mother, but i need experience. Certainty and guidance.
I am feeling the ground going away from my feet as time goes, i had very high hopes in the Graviola/Paw Paw protocol since soooo many state they got well.
I don’t know how much time we have left to experiment with treatments, i need a clear certain solution that will work for sure.
I may be asking for too much, being broke, unable to do more testing, gene sequencing, more blood tests, urine etc.
I hate to leave my results to chance, but it looks like i have no choice, forced by the laws of the universe, i don’t know anymore.
i give up……. the webpage isn’t letting me complete the comment i wanted to post here……………….
HI Alex,
Thanks. I just approved your (long) comment. Was waiting for my approval due to its length. As a result, I will soon erase the others.
I was expecting you will send the story on my e-mail, more structured (with a time line) and I would make a new post out of it so that you get the full attention. If you like that, please work out a bit your comment so that it is more clear and people can understand easy what you went trough (tumor location and treatments), where you are (tumor status and treatments), and your plans (treatments) and we can comment on that.
Otherwise we can keep the comment here as is although it is off-topic on the MG page, but to be honest for me is hard to read it as is. Just think about it and let me know what you like.
Kind regards,
Daniel
Dear Alex,
just see my comment to Paul (scrolling down to the bottom of the page you’ll find the latest posts). I wrote about wheatgrass juice treatment and how a 75 yo woman with metastatic cancer was cured by it. I feel that you lost hope, which outlook should be changed if you want your mom to be healed. Read inspiring stories on the internet, there are plenty of them. Citric acid treatment is great. For ginger, I’d recommend dried ginger instead of just ginger tea, it is so much more effective! Fresh ginger may be even better but takes more to get it. Wheatgrass, citric acid and ginger cost almost nothing. Why don’t you read here the appropriate section about citric acid. And keep up your spirit! How is you mom’s? The most important ingredient is the resolve to want to live!
Kind regards,
Helga
Hi everyone
Daniel, thanks for your work and expertise in maintaining this wonderful site.
I am an integrative GP working with cancer patients, mainly around therapeutic nutrition, herbals, and some pharmaceuticals, cimetidine, metformin, vit D etc. I am trying to find a source of MG, but this is proving much harder than I had hoped!
No replies to emails to India, Chinese manufacturers etc.
I got a small amount off ebay that I’m certain has helped a glioma patient to some degree, but that source has disappeared.
Can anyone help??
Thanks
Matt
Hi Matt,
Thanks for your comment and kind words. For a source you can also contact the Chinese supplier I mentioned on the “Supplier” post. I will send to you by e-mail another reliable supplier I used to be in contact with from China.
Besides the Chinese you can always try to go for the western sources such as S Cruz or others.
Would be great if you could share here a little more of your experience with MG, such as the dose used, side effects and anything you think it may be relevant. Any other opinions on MG or other posts would be very much appreciated. Thanks a lot in advance.
If anyone else has other recommendations on MG suppliers please let us know.
Kind regards,
Daniel
Hi Daniel,
You said i would not use DCA with MG.If we have to choose one,which one is better i am thinking.Ofcourse different mechanisms.
I am thinking to change DCA with MG if tumor markers are still getting higher.
But i wonder DCA and citric acid have similiar abbilities to some degree.Then do we have to stop citric acid and HCA while on MG.
Ofcourse you can say it is your choice and own risk.
Kind Regards
Ergin
Hi Ergin,
First thank you for your kind donation. I will make sure that will get to those that need it the most and I hope you will actually also participate in doing that (as I hope that more of us will unite our energy in the future to help improvement and extension of life).
Regarding your question, I was saying I would not use DCA with MG because MG may reduce the potential of DCA, but not the other way around. If I would have to chose, I would first try DCA since the potential side effects are lower compared to MG. If I would not be happy with DCA and would have no other options I would add MG. In that case, I would think if it makes sense to continue with DCA or not. If I saw no added value of DCA, I would stop that to live place for something else.
Regarding Citric Acid, if is to make it scientific, I would say the following:
– if CA is doing its job, it should inhibit phosphofructokinase (PFK) which is an enzyme that next to Citrate is regulated by ATP: http://www.sharinginhealth.ca/cells_and_molecules/carbohydrates/metabolism/glycolysis.html as a result, Glycolisis should be inhibited.
– if we look at MG, within the cell is being produced at a latter point in glycolisis as a by product
In this case, if CA is effective in inhibiting glycolisis, there will be less MG produced and as a result less MG within the cancer cell. Based on this you could argue that we should better stop CA while on MG so that we maximize the MG production next to the one that we administrated from outside the cell. However, this is betting on MG only. Also note that as discussed in the article above, during chemo more MG will be produced within the cell.
All in all, from MG perspective only, it would help to stop CA while on MG, but from a holistic perspective we may want to maintain CA as it adds one more chance.
Instead of stopping CA I would better focus on ways to inhibit Glo as discussed above, and that also includes stopping Metformin which seems to actually activate Glo as indicated by the article posted recently by Pouya below.
Regarding HCA, from a scientific point of view, there is no reason to stop it while on MG.
I hope this answers your questions.
Kind regards,
Daniel
Hi Daniel,
I read a very interesting article.MG works perfect with chemo.BUT…
The circulating glucose metabolite, methylglyoxal (MG), enhances cisplatin-induced apoptosis by activating protein kinase Cdelta (PKCdelta)
So it says : In diabetes mellitus patients,chemo works better.
Than everything changes?Does it mean that we should not use metformin with chemo?
Does it only changes glycogenesis?
https://www.ncbi.nlm.nih.gov/pubmed/11707430/
Hi Ergin,
The reality is that all the substances that you place in a cell may have multiple targets, some that we know and some that we don’t. For ovarian cancer specifically, Meformin is suggested to hep with chemo or without:
– Metformin Suppresses Ovarian Cancer Growth and Metastasis with Enhancement of Cisplatin Cytotoxicity https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3084625/
– Metformin combined with p38 MAPK inhibitor improves cisplatin sensitivity in cisplatin-resistant ovarian cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4214348/
– Inhibitory effects of metformin at low concentration on epithelial–mesenchymal transition of CD44+CD117+ ovarian cancer stem cells https://stemcellres.biomedcentral.com/articles/10.1186/s13287-015-0249-0
– Metformin in ovarian cancer therapy: A discussion http://www.cancertm.com/article.asp?issn=2395-3977;year=2016;volume=2;issue=4;spage=119;epage=124;aulast=Ouyang
– Metformin reverses drug-resistance of ovarian cancer cells to cisplatin by inhibiting p38 mitogen-activated protein kinase signaling pathway http://en.tumorsci.org/index.php/tumor/article/view/820
– Metformin attenuates ovarian cancer cell growth in an AMP-kinase dispensable manner http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.788.8988&rep=rep1&type=pdf
– Reprogramming ovarian and breast cancer cells into non-cancerous cells by low-dose metformin or SN-38 through FOXO3 activation http://www.nature.com/articles/srep05810
– Preclinical studies of metformin targeting metabolism of ovarian cancer cells and/or ovarian CSC https://www.hindawi.com/journals/bmri/2014/132702/tab1/
– And so on …
According to the above overall, Metformin is expected to help in Ovarian cancers with or without chemo, regardless of the Glo1 activation. Also, do not forget that at this point we only have one paper on Metformin as a Glo activator. But many papers on Metforming as supportive in ovarian cancer case.
We have to learn to decide, in the context in which things are not black or white. I know is not that easy, but that is the way forward.
Kind regards,
Daniel
Thank Dear Daniel,
My brain stopped thinking really today.I wish our brain changes for only some minutes.
I think i am going to drink something.
Cheers Helga:)
Now i recognize,
When we begin chemo firstly mothers blood glucose was 200 nearly.And declined to only 5 with chemo.
May be resistant cells and sensitive cells are different totally.
Sorry ca 125 declined to 5.
Wow, that is a big decline Ergin. What is the treatment you were using? Maybe these comments we can continue on the post dedicated to you so that we keep track of your success 🙂
You catch me Daniel:)
Ok i will write tomorrow,but that was not my success,chemo and nerium oleander did it.
And blood glucose was always high.
And tomorrow adrenalin day as Mr Halabe says.Blood counts day.
It is the result of everything you did and you din not 🙂 It is the result of a longer time you invested in, not just one day.
its always the worst day in my life , maybe I will die someday because of panic and stress from waiting the results
stay strong Ergin , and always know that you didn’t do all the best yet , still I think there is much stronger protocols that you never used
Hi Daniel,
If Metformin may actually activate Glo, would Berberine be a better alternative? This is a very interesting article, not ready yet to pursue as we are trying other modalities right now.
Thank you,
Carol
Hi Carol- I’ll chime in on this one. Nutrients are often complex and have multiple actions in the body. Since there are many studies demonstrating an anti-cancer benefit from metformin, we know that its “big-picture” profile is to provide benefits for those fighting cancer. While it may be wise to avoid it if using MG, I don’t see a reason to avoid it otherwise. Berberine does have promise and acts on mechanisms similar to metformin, but we don’t have the large scale studies to know if it is as potent or efficacious. Personally, I would stick with metformin.
anyone noticed this? https://www.ncbi.nlm.nih.gov/pubmed/24710646
does it mean Metformin should be discontinued while on MG treatment? I had previously came across a contradictory result while researching for my own case though.
Very interesting and relevant Pouya! Thank you for the reference!
Indeed, this would indicate that while Metformin is well known anti cancer drug, one that I like a lot due to its potential, accessibility and low side chance for effects, it should not be used when on MG.
Hi Pouya,
It is very nice to see you here and see you strong.
May be you dont believe but i am always thinking of you.
If we have projects later,it is MUST to see you near us.
Hi dear Ergin,
thanks for your kind words, I have seen you mentioning me in other posts and I believe you and I appreciate that a lot.
I usually go to sleep wishing that I won’t wake up the next day but since I keep waking up and cancer is still all I can think of from day to night, I figured I make myself useful and participate in the fight and yes, I also so wish to meet you guys in person and give you the warmest hug ever and I’m willing to make it happen.wish you the best though your fight. I’ll be here and help as much as I can.
the roles of both s-p BromoBenzylGluthatione and Ethyl Pryruvate seems to be worth looking into? may be the accessibility is an issue here.
https://www.researchgate.net/publication/313946116_Expression_of_glyoxalase-I_is_reduced_in_cirrhotic_livers_A_possible_mechanism_in_the_development_of_cirrhosis
^could this be helpful in treating ascites..
https://www.ncbi.nlm.nih.gov/pubmed/8787553
I just came across this. https://www.ncbi.nlm.nih.gov/pubmed/17396216
apparently Creatine improves the body’s ability to use Glucose!
I wonder if that’s why Prof. Ray didn’t want me to use Creatine at the beginning of the MG treatment. what do you think Daniel?
Dear Pouya,
I checked the subject and here is a review indicating it is not clear if that is true in general.
It seems to be mostly true for the combination of Creatine and exercise https://www.researchgate.net/publication/304005985_Creatine_supplementation_and_glycemic_control_a_systematic_review
Probably, most of the glucose will actually go to the muscles during the exercise.
Besides this, I think you once suggested we should have a place where people can generate new ideas outside the posts I published. I think that is a good idea. Can you please let me know if you have more details on how you imagine that? Thank you.
Kind regards,
Daniel
Thanks for the reply dead D, regarding your question; well, I have a long history of lurking and posting various online forums, and ever since your website has gained more views and posts I thought this place needs to be trimmed a bit for different reasons;
first, because when a new user arrives with all the stress they already have because of the problem they are dealing with (cancer) they may get confused very easily, there are many comments by many different users and one gets lost easily being exposed to all the info,
second, many topics tend to go off-topic after a while, as you noticed some comments under a topic actually belong to another topic, some of the discussion are not even directly related to cancer, etc.
I believe you need to add a forum for the purpose of general discussions in which users are allowed to come up with what ever topic they want and others can participate and brainstorm to see if anything real comes out of it. then, if for an instance the info regarding that subject could be backed by enough science to make it worthy, you can add it as a post to the core of your website. if not, it still helps your website to stay science based the way you want it to be.
it also has the benefit of putting the burden of some the research off your shoulders. e.g. you can make a topic, regarding a hypothesis where the element X is worth looking into as a cancer treatment, then others can participate and add whatever they can to that specific subject until a there are enough info that a published article can emerge from it.
this is something that can be improved later of course. this is just a rough idea.
Hi Pouya, thank you. I understand and will consider starting a forum section. Just that it requires time to set that up and I am one person only. But I promise that will come at some point.
I realize it may be too difficult for some readers following all the comments. And there is no way to trim the discussions or to constantly ask for comments in the right article. Do you think is better not to allow comments on future posts, in order not to have the readers confused? Thank you for your comments and suggestions, Pouya. I always appreciate constructive feedback.
I was actually thinking along the same lines as Pouya, specifically after seeing the CA thread and having it be tough to navigate comments.
I personally think comments should stay. They’re a pretty valuable part of the site specifically because they give us case reports on the various treatments which is as valuable as the theory contained within the actual articles.
Thanks Meech.
Hi Daniel, with a forum, each on the treatments discussed here could have a separate thread for case reports, personal experiences, etc. I’d close the comments under your published articles and let the comments go there. another advantage of a forum would be threads for treatments that do not have an article on your website for various reasons, (you have not been able to write and article yet, they are not valuable enough to be mentioned, etc, like LDN , GcMAF or others that you know better)
Goodness me, I am learning so much on this amazing forum. I have been fighting for 4 years, and I have learned so much in one afternoon. Keep up the good work. I had never heard of MG until today 🙂
Dear Daniel,
I am highly excited when i learn this.
MG Methylglyoxal inhibits both mitochondrial respiration and glycolysis.
This drug is what i want to try with hyperthermia.
I dont know if you gave this link before :
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1218325/pdf/9163322.pdf
But as we know MG also inhibits mitochondrial respiration of hearth cells.
”Protective effect of creatine against inhibition by methylglyoxal
of mitochondrial respiration of cardiac cells”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1223401/pdf/12605598.pdf
I wonder is it really a promising drug or just like citric acid on lab.
Kind Regards
Ergin
if we trust the results done by prof Ray then it should be more powerful than most of the existing cancer treatments , otherwise its not clear if it can help or not
Hi Ergin,
My feeling regarding MG is that is higher risk/higher reward compared to citric acid. I actually see MG from a potential point of view in a category more towards those like 3BP, Sal, Diflunisal. Somewhere between these and DCA if I would place them on a scale of potential effectiveness based on my feeling. But I also feel it comes with risks, although maybe not that high as compared to Diflunisal that comes with bleeding risks (however we use it intensively with no bleeding).
So I would not compare MG with CA.
Kind regards,
Daniel
By contrast, phloretin, phlorizin, and 4,6-O-ethylidene-D-glucose bind to the estimated import site of GLUT1 (42, 43). Cytochalasin B, phloretin, and phlorizin inhibit the activity of GLUT4 also (44). However, these drugs do not inhibit yeast Hxts.4 Furthermore, as far as we know, no drugs capable of inhibiting yeast Hxts have been found. In that sense, our finding is the first to show a chemical that inhibits yeast Hxts.Thats MG.
http://www.jbc.org/content/287/1/701.full
Is it MG which we are using now?
There are clinical trials in 80’s.
Effectiveness of methyl-GAG (methylglyoxal-bis[guanylhydrazone]) in patients with advanced malignant lymphoma.
http://www.bloodjournal.org/content/57/6/1011.long?sso-checked=true
Hyperthermia and MG(1983)
https://www.jstage.jst.go.jp/article/cancersci1959/74/2/74_2_226/_pdf
Enhanced antitumor efficacy with a combination of hyperthermochemotherapy and thermosensitization with polyamine antimetabolites in nude mice(1987)
https://link.springer.com/article/10.1007/BF02470650
And article about DFMO.
Polyamine deprivation: a new tool in cancer treatment.
https://www.ncbi.nlm.nih.gov/pubmed/8017845
http://neuroblastoma.ca/dfmo/
hi ergin
i ve just read this :
https://medicalxpress.com/news/2017-09-body-fat-metabolism-effects-sugar.html
it seems excess of methylglyoxal is not good (when it s produced by the body)
i don t know what to think else of it?
I’m giving my mother MG these days but I’m not worried about such side effects , the only thing I’m worried about is taking excessive chemo which is worse than all MG possible side effects in my opinion
Thanks a lot Ergin! Very nice findings!
while I really appreciate all the great work you have done and think MGO has a strong antitumoral effect,as long as you are JUST focusing on killing cancer cells/getting rid of tumors (naturally or with synthetic drugs) and forgetting about seriously building/strenghtening the immune system(a weak immune system is why cancer cells get out of control and why cancer can grow!) you will never heal cancer-even if you manage to get rid of all the cancer cells in the body, if the immune system is weak ,cancer will return(and it’ll probably return in the same places) – i.e.:have a look at how the annecdotal patient in Netherlands is doing.or how cancer returns in other patients after surgery or chemo/radiation or after getting rid of tumors by other means !!!
there are so many treatments that can get rid of tumors but if you want to heal cancer for good/long term ,getting rid of cancer cells is NOT a top priority(except when tumors are putting life in immediate danger -i.e. occlusions) .sure, it sounds good and gives peace of mind but cancer is like a fungus-whipe it out with chemicals or with a cloth and it’ll return;change the environment pH and it’ll disappear for good. the same with cancer:raise the pH , build /STRENGHTEN THE IMMUNE SSYSTEM and make sure the cancer patient SURVIVES while doing these and you’ll be safe .
have a look at some statistics:http://issels.com/statistics.aspx
with the Issels immune Treatments, so-called ‘incurable’ cancer patients have led full cancer-free lives, some for up to 45 years, and as follow-up to conventional treatment, the cure rate is as high as 87% .
I really hope this will help you help others even better in the future.great work but focussing on killing tumors and forgetting about the immune system will get you back to where you have started(best case scenario!)
GOD BLESS US ALL!
Dear Cristian,
Thank you for your comment. I do agree we need to also focus on supporting our immune system. But I do not agree that blood pH will be enough as you stated, to cure cancer. That is not a believe but a fact. I know clinics focusing on that approach and it is clear that is not enough. Also, while I believe and saw advanced cancer patients who eliminated their tumors with the help of various treatment approaches at various clinics around the world, 87% cure rate claim of a cancer clinic tells me you should stay away from them.
There is a lot of time that I allocated and will allocate to this website. But I must admit that I only addressed below 10% of all the points I would like to address. So this website does not so far addresses the whole spectrum of approaches that an cancer patient needs to take at the same time. I did not discussed yet the impact of mind, of diets, etc. which I think are very relevant pieces of the puzzle. I also did not discussed yet ways to increase the immune system activity – I intend to do that when I find the time. Instead, I decided to start by first sharing some of the strongest weapons I found that can help address advanced cancers. Those are the cancers that will not response to a change in blood pH as you suggest, in most cases. Also, those are the cancers that do not respond to an improvements of immune system activity. For those, you need more effective treatments that can affect directly the tumors. I do think, that when cancers are in very initial stage, immune activation will help. But when you deal with advanced cancer, the story is different because of multiple reasons.
I do recognize the origin of your statements. I read a lot of the website stating that, at the beginning of my dive into the cancer world. But most of those statements are not rooted into serious science but mostly are anecdotes. And during time, I saw patients following those anecdotes with no success. That was when I realize that the first filter we need to apply when information comes to us, is the scientific filter. You have to ask yourself: Is there strong enough scientific evidence? If yes, are there peer reviewed case reports where human have been cured using that approach? And if the answer is YES, it means you are on to something real. If not, skip it fast and move forward. I am not saying that this route will offer you 87% chance of success. But it will help you filter out the noise and focus on approaches that offer real chances for response.
Cristian, I know you are very well intended man (as I think we did had a few e-mails exchanged) and you believe in what you are writing. But my friendly advice is to zoom out a bit from that perspective you are focused on now, and look from other perspectives too. Again, I believe that immune system is important and should be addressed. But tumors create an environment in which activated immune system does’t work. And that is not only related to extracellular pH, but much more than that. This is why I think when designing a treatment strategy you need to address multiple cancer hallmarks and make sure you include the most relevant ones.
Kind regards,
Daniel
Dear Daniel, I not that of a good man but I wonder where I mentioned raising blood pH (of course you know it is not good messing with blood’s ph ) and that being the answer to cancer?
As I made myself misunderstood I will say again I was referring to the ENVIRONMENT’s pH(meaning pH of cells and their surroundings) to STOP THE RAPID SPREAD (cancer spreads faster in an acidic environment) of cancer or even put them into hibernation or kill them(i.e. see cesium chloride, baking soda etc)- you have addressed this issue as far as I know.
indeed there are so many urgent matters that need to be addressed with an advanced cancer patient (and I am glad you are aware of that) and one must address them according to his specific situation;
focusing on mainly killing cancer cells fast is not what we need to focus – i.e.you know the body and liver must be able to eliminate dead cancer cells or the patient could die! my point is we need to be balanced and work on a multitasking approach.
Measuring progress /results solely on size of tumors is a trap(i.e. tumors might “apparently grow” due to the immune attack) as well as relying on what is ‘strong scientific evidence’ is a BIIIIIG trap(and by strong scientific evidence I am referring to what the medical community is acknowledging at this time ).
I will quote 2 Nobel prize winners Otto Warturg and Linus Paling:
“Everyone should know that the ‘war on cancer’ is largely a fraud” Linus Pauling
” Many experts agree that one could prevent about 80% of all cancers in man, if one could keep away the known carcinogens from the normal body cells. This prevention of cancer might involve no expenses, and especially would require little further research to bring about cancer prevention in up to 80 percent *).
*) Since this estimate was published, some though 80% even to low. Yet prevention remained taboo and early diagnosis was the only consolation that was offered.
Why then does it happen that in spite of all this so little is done towards the prevention of cancer? The answer has always been that one does not know what cancer or the prime cause of cancer be, and that one cannot prevent something that is not known.
But nobody today can say that one does not know what cancer and its prime cause be. On the contrary, there is no disease whose prime cause is better known, so that today ignorance is no longer an excuse that one cannot do more about prevention. That prevention of cancer will come there is no doubt, for man wishes to survive. But how long prevention will be avoided depends on how long the prophets of agnosticism will succeed in inhibiting the application of scientific knowledge in the cancer field. In the meantime, MILLIONS of men must DIE of cancer unnecessarily.
” Revised lecture at the meeting of the Nobel-Laureates on June 30, 1966
at Lindau, Lake Constance, Germany
by Otto Warburg
Director, Max Planck-Institute for Cell Physiology, Berlin-Dahlem
English Edition by Dean Burk
National Cancer Institute, Bethesda, Maryland, USA
The Second Revised Edition
Published by Konrad Triltsch, Würzburg, Germany
1969
You see Daniel lot’s of NATURAL treatments work and have a great amount of science behind them (and you will realize this if you start putting into practice NATURAL treatments that former patients say work ).
The main problem is we live in a world where conventional medicine is not looking for the best treatment (wich is in most/probably all cases a natural remedy God has already built as the Bible assures us) that but for the most expensive.
NO mane maker, no ‘scientifc evidence’.
There have been so many cases of excellent cancer treatments that have been buried or classified as quacks by FDA( Hoaxey’s plant based remedy , Gastons Naessens dark field microscope finding’s about the pleomorphic microoorganisms behing cancer, Royal Rife machines that kill these pleomorphic microorganisms,Linus Pauling’s Vitamin C , Gerson & Kelley metabolic regimes , Johanna Budwig’s diet based on Wartburg’s and Szent Gyorgi’s discoveries, Dr. Burzinsky’s antineoplastons….most…probably all natural cancer treatments have been classified as quack due to ”lack of scientific evidence’ – why?! why oral vitamin C instead of IV administration used in Mayo’s trial, why diluted sollutions, why prosecute BUrzinski and Kelley and Gerson and Issels even though they have had so many cured patients and well documented data….why is the case that almost always they use diluted or mess with the formulations to ‘prove’ these treatments do not ‘have scientific evidence’? why did the ‘scientific community’ try to reject Wartburg’s finding’s up until recently ? why feed the cancer patient sugar even though they use PET /CT knowing sugar gets directly into cancer cells?!!)
On the other hand thanks to good people who risk(ed) their lives (i.e.: Nicolas Gonzales, Dr Riordan who is died just before publising the clinical trial on IV vitamin C and other people willing to risk their lives to help others …solid scientific proof starts to pop up on pubmed and other similar scientific communities’.
But until things will clear up and scientific backup will show up on pubmed and the conventional scientific community will start applying these there might be another hundred years-keep in mind Wartburg won his Nobel prize in 1931…what did the scientific community do since then to build on his work?!Mostly classify his findings as wrong?(I really like the above MGO treatment as it confirms and links Wartburg’s, SzentGyorgi’s and Pauling’s findings )
My advice to you is to investigate better natural,plant based treatments backed up by testimonials even though they ‘lack scientific proof ‘ or ‘have been classified as ‘ quacks’ .I think you will be surprised to see they actually and practically work.
I did this experiment and this is my experience with cancer patients:
1. no matter the stage, God and God’s creation( Nature) work.
2. Nature does not work well or does not work at all ON LING TERM when combined with ‘scientifically proven’ chemotherapy and radiation.
I will say on more thing from my heart to you :
I have seen my mother’s case and other’s similar cases impaired by chemo and radiation and how they struggle and die even though they eventually try natural remedies as a last resort.
And I have known other people with same type of cancer in more advanced stages that doctors gave days/weeks to live and they got better with natural treatments.
And I am not the only one that has had this PRACTICAL EXPERIENCE.
When you actually know these you cannot shut up knowing people are taking a wrong path. I loved and love my mother and I want others to benefit from our experience.I want others to chose wisely
Please analyze LONG TERM outcomes from both sides: conventional medicine( with serious side effects and and 5 years SURVIVAL rate(NOT cure but SURVIVAL) ) and natural medicine ( almost no side effects, with cured patients, people THAT ACTUALLY EXIST but ‘scientific community’ classifies as ‘lack of proof, more studies needed, etc’ -i.e: see Burzinski’s trial if you do not believe me- CANCER IS A SERIOUS BUSINESS :https://www.youtube.com/watch?v=rBUGVkmmwbk )
did you have a look at the issels results and case though?!
http://issels.com/statistics/
http://issels.com/testimonials-updates-reviews/
Please excuse me. God Bless Us!
Hi Cristian,
I will respond asap. For now, addressing a few of your points:
– what I just want from us is to go beyond pointing fingers to anyone suggesting that someone is against finding the cure. I think it is the framework that we build as society that is not the right one to facilitate a fast progress. And that is what we need to change. But that takes time and will be a long term project. I will be happy to discuss with you any anyone else what could be the ways to achieve that. On short term we have to look in an unbiased way at anything that may be effective and expose that.
– I use the “scientific evidence” as a filter. But that doesn’t mean that I do not have an eye on the purely anecdotal ones. I always do. But “scientific evidence” filter I found to work well. Note that in academic space, there is a large group of researchers who are investigating substances without the business reasons behind, making the scientific evidence unbiased in many cases. Their results include many many natural products. Some of them I already addressed.
– I know people who have good outcome with Curcumin and I know people who have good outcome with Chemo. So, suggesting to people to go one way or the other will not make me slip well at night. Who are we to suggest what is better. What we should do is to expose new treatments that may be effective or ways to improve current treatments, based on scientific and anecdotal evidence. And people should decide what is best for them.
Yes, it is clear that the chemo route is more likely to come with strong side effects, including lethal. That is well known, and people need to consider that as well.
In order to progress we need to move forward in a constructive manner: i.e. we need to get the best out of this world whether it comes from an university, a pharma company, an alternative clinic/doctor/scientist or any other source such as TCM.
Kind regards,
Daniel
hi Cristian,
the problem with this “immune approach” is that many types of cancer simply trick the immune system and if you make the latter stronger you will just fail quicker. There are lab studies proving that lymphocites are helping tumours to grow. This is one example…. Think of the very healthy people who get cancer …. On the long term the immune system is super important but on the short and middle term we talk about cells that are not identified by the immune system as cancer…
who/what is stopping you at helping the immune system identify those cells? digest those proteins that coat the tumors with proteolitic enzymes, raise the ph around cancer cells, starve cancer cells with cesium chloride…there are so many techniques that help the immune system recognize the cancer cells.
the problems with building the immune system are:
1.it is slow process so you need to make sure the patient survives while you do it;
2. inflammation and swelling occurs when the immune system recognizes and attacks cancer cells-but again, you have lots of great anti-inflammatory substances such as DMSO/MSM, cucurmin,boswellia,etc.
the immune system is the key to making sure you get rid of cancer for good but there are always other more urgent problems with a cancer patient you need to address – and you must address these as well or the patient will die
Dear Cristian,
I so much understand your angle.
The elements you mentioned are good, with the exception of cesium chloride. However, all those elements are not enough when fighting aggressive and advanced cancer. We tried them all and intensively in our first year (with the exception of cesium). I know also doctors who tried cesium chloride on many patients and no response – only complications from that.
I like enzymes and we used constantly high dose of some of the most relevant ones – I intend to write a post on that too. But it is not enough for most people. In theory sounds great to use enzymes to digest proteins that coat tumors and activate the immune system, and that’s it. I know those stories very well. In reality enzymes (not all but those used in alternative world) are a too soft approach for advanced cancers – one that should be used as a background approach but not as a main approach.
Actually, I even wrote a post on an approach to digest a coating around the tumor https://www.cancertreatmentsresearch.com/the-hyaluronic-acid-cage-to-open-or-not-to-open/. But when you are effective in doing that, you may trigger metastasis in case you do not combine that withe an effective treatment that can kill the exposed cancer cells. Activating the immune system, as we discussed before is not enough to ensure its anti cancer effectiveness. So that means when you really succeed to open up the coating, you need some treatment around with a good chance for effectiveness. That is what this company is trying to achieve while being in clinical trials http://www.halozyme.com/homepage/default.aspx
DMSO is a great tool – but again, alone it doesn’t do much – it can however help increase the effectiveness of other treatments. (I know it very well as it is used IV in alternative clinics)
pH subject was discussed here https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/ and I think the best approach to re balance pH around the tumors is not to focus on outside but on inside using proton transport inhibitors or even better, focus on inhibiting fermentation (glycolisis). That is working at the origin of the acidity. We discussed many inhibitors of fermentation on this website.
I like Curcumin, I like Broswellia, I like DMSO, I like enzymes, but all of these are not enough to fight advanced cancers. (The exception in my view is Curcumin IV that can be effective in reducing tumors as I do know people who experienced that.) These and many more natural supplements, I would use them as a background treatment. But on top of this, we need to add the “tip of the arrow” treatment. That is what I am trying to address here.
Finally, I think that your first question still doesn’t have an answer today. If it would, cancer would be cured.
Immune system is extremely powerful – better than anything. But no one today, understands why it does’t work against cancer. There are off coarse a lot of ideas, and some may work in some cases, but the world is still walking in the dark when we speak about understanding the immune system.
Since we do not have time to wait until the world understands the immune system and create effective solutions based on that, we should work in parallel and attack cancer from angles that we think we understand better, and that have been proven (by trusted sources) to be effective in humans.
I hope one day we meet and discuss these points in details.
Kind regards,
Daniel
a little something about immunity on the long term:
https://www.ncbi.nlm.nih.gov/pubmed/12060116/
Cesium chloride works and is very powerful but causes inflammation and swelling and a lot of problems (serum Potasium levels go down etc – you need guidance )
„Many human trials have been carried out by [late] Dr. H. Nieper in Hannover, Germany, … as well as a number of other physicians Overall, the results were satisfactory Oart f .. He noted that all pains associated with cancer disappear between 12 and 24 hours, except in very few cases where there were problems of morphine waiver, which requires a few more hours. „
Many celebrities and executives in America went to Germany to be treated by Dr. Nieper, including a U.S. president. Dr. Nieper died in 1998.
http://www.cancer-coverup.com/brewer/printbrewerreport.htm
Cesium treatment achieved a cure rate of 50% in patients with very advanced cancer, some already in a coma. 47 of the 50 patients were „hopeless” and some had only days to live .Doctors have given very high doses of cesium . http://www.newswithviews.com/Howenstine/james14.htm
H.E. SARTORI – HUMAN STUDIES
Excepts from „Cesium Therapy in Cancer Patients”
Treatment was performed on 50 patients during the last three years at Life Sciences Universal Medical Clinics in Rockville MD and in Washington D.C. All patients were terminal subjects with generalized metastatic disease. 47 of the 50 patients studies had received maximal modalities of treatment, i.e., surgery, radiation, and various chemotherapy, before metabolic Cesium-treatment was initiated. Three patients were comatose and 14 of the patients were considered terminal due to previous treatments outcome and cancer complications.
The Cesium-treatment was given in conjunction of other supportive compounds under diet control in addition to the utilization of specific compounds to produce adequate circulation and oxygenation. According to individual cases Cesium Chloride was given at daily dosages of 6 to 9 grams in 3 equally divided doses, with vitamin A-emulsion (100,000 to 300,000 U), vitamin C (4 to 30 grams), zinc (80 to 100 mg) selenium (600 to 1,200 mcg) and amygdalin (1,500 mg) in addition to other supplementations according to the specific needs of the patient. The diet consisted mainly of whole grains, vegetables, linolenic acid rich oils (linseed, walnut, soy, wheat germ) and other supplemental food. To increase efficiency of the treatment and improve the circulation and oxygenation, the patients received the chelating agent EDTA, dimethylsulfoxide (DMSO) and also a combination of vitamin K and Mg salts.
The 50 cancer patients studied over 3 years had generalized metastatic disease, except for 3 patients. Initial death occurrences for the initial 2 week treatment was in the same order and magnitude of these recorded for the 12 month period. The percent of survival of breast, colon, prostate, pancreas, and lung cancer accounted to approximately, 50% recovery which was higher than that noted for liver cancer and the lymphoma patients treated. An overall 50% recovery from cancer by the Cesium-therapy was determined in the 50 patients treated. Data from the autopsy made indicated the absence of tumors in patient dying within 14 days of the Cesium-treatment.
One of the most striking effects of the treatment was the disappearance of pain in all patients within 1 to 3 days after initiation of the Cesium-therapy.
Though it is a very powerful treatment and can offer terminal cancer patients many chances, CESIUM comes with many WARNINGS (warnings that many cesium vendors „fotget” to mention) and should NOT be used by everyone(ATTENTION those with DANGEROUS TUMORS( any situation when the temporary tumor swelling or inflamation can put the life of the patient in danger: BRAIN cancer, LUNG cancer,etc. ).
Also , Potassium levels MUST be monitored.
https://tratamenteanticancer.wordpress.com/2013/10/31/cesium/
yes,as I also stated, we need a more complex approach than taking just some supplements(these supplements are also good at what they are doing-they are just pieces of the puzzle and I agree the puzzle has not fully completed yet for all cases but lots have healed)
My question regarding ‘scientifically proven’ could have been different-how do you expect to find a long term solution to cancer by researching among data that does not offer a long term solution?
I know the stories Cristian, but unfortunately all the feedback I have from doctors and patients is that Cesium doesn’t work. Trust me, I would very much like that to be a positive feedback and immediately I would write a post on it. I am always open to change my view if there is evidence I am wrong since life of people is what matters not my beliefs.
Regarding your last question C:
What do you mean with “researching data that does not offer a long term solution”?
If you will read my post, you will find references to reports showing long term response to various cancers based on various substances (drugs and non -drugs; natural and synthetic).
hi Daniel,
as to why the immune system does not work against cancer; australian researches investigated this for breast cancer. They noticed that the cancer cells had knocked out the gene IRF7. this gene is responsible for producing the key immunprotein called interferon. Cancer was blocked in mice when they added this gene or interferon …
Conclusions are somewhat blurry as then again… we do not seem to be able to cope with cancer using genetic meds…
Thanks, W!
tratamenteanticancer.wordpress.com/2017/09/18/dovezi-ca-remisia-continua-pe-termen-lung-la-pacientii-cancer-depinde-de-puterea-sistemului-imunitarsi-nu-de-chimioterapie/
https://www.ncbi.nlm.nih.gov/pubmed/12060116/
there are many other potent treatments like mgo or cesium or vitamin c or honey , cucurmin, etc but these are just pieces of the puzzle and I do agree the puzzle for all cases has not been solved – but for some it has been and we should learn from those long term remissions even though thy are ‘anecdotal stories’.
I simply cannot understand how we may learn from ‘scientific’ cases that lack long term results , focus solely on putting tumors into remission and accept only 5 year survival rates, NOT cures.
I really am very enthusiastic about studies popping out confirming WARTBURG’S , SZENT-GYORGI’S,PAULING’S and other findings of great scientists that date from last century;but that is also my problem-they date from last century and they are only popping out now and in limited amount and in combination with conventional treatments that have shown no major improvement for over 50 years.
who knows how much it’ll take to solve the puzzle on pubmed 🙂
I think cancer patients who will manage to heal their cancers will help you understand my point that GOD’s nature has always offered great results (if it is God’s will for them to heal) whereas no major improvement in last 50 years in conventional oncology speaks for itself;
I think I worry to much as from what I see you seem to be smarter than I am-you just need to work with patients more;I do agree with you we cannot tell people what to choose but we can present them facts (and facts include real stories of other patients that have healed from cancer, even though they are not on pubmed (or similar) yet ; beware of psychotherapies though – yoga, meditation , kundalini , reiki, silva, mind control and other techniques that make man think he is godlike 🙂 )
God bless us all!
Thanks but I think we are all smart here. That is what brings us together here: being smart and proactive. I do not intend to work with patients – that would be too much for me in terms of responsibility. Otherwise, my exposure to the real world has been extreme, unfortunately. Not to speak about the constant feedback I receive via doctors and patients from around the world on what works and what doesn’t … that for me is enough exposure to the real world, for now. Regarding the pubmed, the value of having something published there is that the claims are checked by referees (although that is not a guarantee since these days there are so many unchecked or poorly referenced papers – this is why you still need to make your own due diligence).
An example of a pressure test for using scientific evidence vs not using that is e.g. Curcumin vs. B17.
Check for the science on B17 and you will find very little trusted sources supporting that. Check the science on Curcumin and you will find a huge amount of trusted sources supporting its anti cancer potential. Next check with an unbiased cancer clinic for how many cancer patients have responded to B17 and check same for Curcumin. Then you will understand my point. But please check this with unbiased doctors from alternative clinics, and avoid those using the anecdotal marketing behind B17.
to prove I really appreciate you work (and envy you to some point 🙂 ) , I am picking up some studies and treatments presented here;but from what I have witnessed from discussing with cancer patients, I cannot agree with conventional treatments too much , that is why I was so ”aggressive” above ( I do not others to suffer ).
Thanks Cristian. I would appreciate if you add links to this website when you are going to write articles based on the content consolidated here. I very much understand your irritation regarding current status in the cancer treatment world. I am one of those who can understand it the best given the loss of my dear wife. But I think we need to consider all the tools available in this world, and perform a strong pressure test on them since the world is full of anecdotes.
I guess that We all share the feeling that more could be done, that this should be already solved, and that me should not be here looking for an answer of how to help my family menber or even myselft. This feeling of wake up and check for some usefull new about this…
By the way, i found today this, https://www.ncbi.nlm.nih.gov/m/pubmed/28912244/?i=2&from=/trending ,
Considering true, what we are fighting?? Such a simbiosis?? I belive or this is customized, something like bacteriogram, or no solutions in short times . Bacterias inside tumor, that helps to be resistent!!!
Very very interesting Jandro. Thanks for the link. This reminds me of a very good scientist from US who suggested I should always treat my wife with anti parasites, anti bacterial drugs prior to any major treatment like chemo or 3BP or anything I expect to be effective. Exactly due to the reasons explained in the article.
This article reminds me that such approach (anti parazites/anti bacteria) may have to be a rule prior to initiation of anti cancer therapies.
Also note that this article was published in Science, one of the most prestigious scientific journal where usually only breakthrough discoveries are published.
Not the first time a ‘bacteria’ has been seen inside cancer cells:
https://tratamenteanticancer.wordpress.com/2013/11/08/cancer-fungus-the-link-between-the-microbe-and-cancer/
https://tratamenteanticancer.wordpress.com/2013/11/16/alkalinity-cancer-mcrorbes-advanced-cancer-theory/
meglioxal is also antibacterial
Hi Cristian and All,
what an amazing find! And how much these pioneers were maligned by the mainstream cancer industry for claiming they saw “microbes” in the tumour! Now published also in Science… I haven’t read either article in full, sorry. But drugs become resistant often due to an ABC transporter protein that will carry the drug back to the outside of the tumour. And these transporters also exist in bacteria, cause of resistance to antibiotics. Could that be also the mechanism to account for the resistance of the tumour, I wonder?
Best,
Helga
hi Helga- please send me/us that link from Science.Thanks in advance!
Hi Cristian,
it is referenced by jandro 5 messages above yours 🙂
regarding ABC transporters, that is only my musing. But bacterial and human ABC transporters show about 30-50% sequence similarity on the protein level, so if they saw such phenomenon, they could distinguish between the human and bacterial variant by sequencing it.
true.i thought you were referring to something else.
I think it is best to contact biologist Gaston Naessens at http://www.cerbe.com for more details.prof Robert Young has also seen them using dark field microscope.Interestingly, a relative of a patient I used to talk to(had some kind of sarcoma if I remember correctly) sent probes for biopsy and pleomorphic nucleus (es) were noticed
are you referring to Robert O Young? He was arrested recently for his “pseudoscience”. There is a blogger, “science-based medicine” who is apparently a paid shill for big pharma, who blogged about Young.
Dear Cristian,
Firstly thanks for entering this communication,we really need those kinds of arguments here.This makes us stronger and knowledgable.
I have a question for you.
How did you come to Methylglyoxal post ?
What makes you to come here?Which searching?
Is it because of a treatment which done before:
Cow urine treatment which has MG inside.
Do you think also in antineoplaston therapy, urine
is used?
Kind Regards
Ergin
I know Daniel so I ha a look at what is strong and natural on his website;not a fan of urine therapy though as there are so many natural aproaces that do not imply urine…
Dear Emad,
Please look at this link.Daniel also mentioned it before.But i think it is very important.
May be thats why some patients doesnt respond to MG.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2891514/#!po=45.4023
Kind Regards
Ergin
Thank you very much dear Ergin , yes GLO1 overexpression may lead to resistant
unfortunately I’m not addressing this issue and just hoping that there is no such problem with my mother , I don’t have curcumin , and I don’t think that turmeric is enough to address the issue
we wouldn’t know if MG is working , probably we may need to add more
I have become excited about the idea of combining a range of synergizing chemicals with MG.
The suggestion above is to combine MG, vitamin C, B vitamins and Creatine.
I have started to wonder why not use the tumor specific forms?
NanoMG was found to be up to hundreds of times more powerful than straight MG.
Anyone know what the toxic dose of NanoMG is?
You could then add in other tumor specific formulations:
PMID: 25999714 Chitosan MG NanoMG
PMID: 14641067 Tumor specific GSH depletors
PMID:22007962 Tumor Specific curcumin
Chitosan Vitamin C online sources
Not so sure about the curcumin because you would want to stay away from anti-oxidants when using pro-oxidant Vitamin C. Would be great to add in a tumor specific Glo-2 inhibitor. This would deplete GSH levels.
Being specific in this way one could have a very large effect on the tumor.
It was suggested above to use a fairly modest Vitamin C dose of perhaps 400 mg.
What why a larger dose was not suggested?
HI J, there are so many effective drugs that could be brought to the tumor via encapsulation …. I also very much like this idea and it should be so easy to implement based on the existing science and technology … but somehow that does not happen which I find it strange. I hope and expect one day we (and by that I mean you, I and others interested) will be able to do it.
You forgot a Glyoxal remedy made by Heel:
http://www.homotoxicology.net/matmed/combo/2i.vgt.htm
https://www.paulsmarteurope.com/glyoxal-compositum-ampullen-ampoules-10-x-2-2ml/
https://pharm5.com/glyoxal-compositum-5-ampules-2-2-ml
Reference
This comment was moderated due to unsuitable content. Thank you for your understanding and please post valuable content.
22mg per 2.2ml? That’s like 1/15th the concentration of the scbt.com source.
lullabyman, MG has you thinking too?
What would happen if all energy supply were removed from cancer cells, while normal were undisturbed?
The metabolic perspective greatly simplifies what can be an overwhelmingly convoluted topic.
I typically search out the leading edge of the fancy science, though there are now quite a few apparently innocuous chemicals that when combined properly could have very large anti-tumor action!
This judicious avoidance of an optimal response, that you noted, was most strongly noticeable to me with the methylglyoxal, vitamin C, creatine combination. 400 mg of vitamin C (as you noted in the form of Chewables?)??? Is that a joke? 400 mg of vitamin C might give you a pro-oxidant effect!!!
Why go with the minimum possible vitamin C dose? I am not totally sure what the state of the art of maximal vitamin C iv dosing might be, yet 200 grams might not be far off! We have reached an era of cancer research where there is an apparent lack of effort to gain every last inch of treatment power. Back in the 1970s there were human clinical trials in which a substantial percentage of the cancer patients had fatal side effects and the trial would continue without stoppage! In the current era there is often a large dose buffer in order to avoid toxicity of any kind even in the lab models. Avoiding any and all potential for the possibility of even temporary mild side effects is not consistent with the best interests of desperately ill cancer patients nor is it consistent with international human rights legislation.
Yes, the vitamin C + doxycycline was an impressive result; one does see how substitutions might be advantageous. Hmm, vitamin C is a not so good an OXPHOS inhibitor? That sounds right, though of course references are wanted and needed! In terms of buying methylglyoxal without prescription, does this include chemically refined MG or only the refined Manuka honey?
I remember seeing the Puerto Rican vitamin C study. It was just that I am always worried that something unexpected might happen when a treatment is changed around. I would not think that a combo of metronomic vitamin C and MG would cause trouble, yet with these combinations it is almost certain that they will never be tried in a clinical trial. In fact, some of these do not appear to have even been adequately tested in lab models! One is always left with a certain uncertainty. As it is there is vitamin C, MG, and 3-BP which all have strong monotherapy selectivities for glycolysis and/or OXPHOS. Putting them together in an optimized treatment could give very impressive results.
One might simply start with the basic treatments, acquire a comfort level with them and then up dose and reformulate.
Perhaps a treatment could be something like:
-Start with the generic MG protocol: 40 mg/kg/day oral MG taken in 4 divided doses, 500 mg oral vitamin C chewables, creatine etc.
– With the generic protocol up dose the vitamin C and switch to iv dosing.
– Perhaps updose somewhat with the MG.
Fortunately there is an MG scavenger, aminoguanidine, so you can also have the comfort of knowing that you can control the downdosing PMID: 26530987
-Move to iv MG dosing. D’s dosing suggestion for iv MG was 10 mg/kg/day which I would guess would give you much higher blood levels of MG. Still this would be 500+ mg per day iv which seems like quite a bit. It shows me that there is a fair amount of wiggle room involved in the dosing.
– As the comfort level increased one might consider moving to NanoMG. PMID: 25999714
I realize that most people want to avoid the synthesis route, though the benefits available from this synth are notable.
The method that was used involves no complex chemical lab procedures at all.
The big problem that appears to eternally recur when people avoid the synth lab is that they will up dose on the raw chemical: this is typically a very poor strategy. In one of the figures I saw on MG, it was quite startling to see that once a high dose was reached, even doubling the dosage resulted in no further increase in concentration in the cancer cells. What you would be doing is simply increasing the toxicity for all the normal cells.
I have gone through your entire article. My 19 yrs son is suffering from Alveolar Rhabdomyosarcoma since 2016. Now he is under 4 drug palliative chemotherapy. This was also kept on hold since last 15 days due to raised liver enzymes. By this time, I met Dr M.Ray who happens to live in Calcutta, India. She has advised me to start MG. Please, enrich how far will it be beneficial in regression of metastasized tumors? Is there any negative side effects of MG?
Dear Nabin, I am so sorry to hear about your young son … I do not have more information to share other than what is consolidated here. If the liver enzymes are very high I would discuss with doctors (conventional and alternative) options to lower those. In alternative space, treatments used to improve liver condition on short term are Hepametz intravenous, Alpha Lipoic Acid intravenous and Silymarin. Kind regards, Daniel
Hi D and All,
Am I correct in thinking that acute side effects/reactions to methylglyoxal are unusual and that side effects are more related to damage to the arteries, heart, brain etc over the long term (I did see the case in the safety section regarding the acute fever)?
Thanks for the great post!
Hi Shanti,
Yes, those are the concerns. The other one I heard from some people was related to a faster regrowth of tumors if methylglyoxal is used for a short period only. However, I think this is a concern for any effective drug, including for chemo when that is effective as well as 3BP and others.
When I considered using MG what I did not liked was the relatively aggressive aspect of the solution – but that was just a personal view which I haven’t heard from others.
My view on MG is that I would use it only when there are no other treatment options left.
However, the homeopathic version can always be tried without the above concerns.
Kind regards,
Daniel
Hi Daniel,
My husband is stage IV prostate cancer and ADT has been failing and since the end of June, he added Fenbendazole daily – dosage of .8mg. We see great benefits, a return of appetite and energy. But it doesn’t seem to slow PSA rise. I like the benefits of MG but wonder if there would be negative interactions with FZ. Th hope is that MG might target different pathways that the cancer cells are using. Can you offer any thoughts on this?
Thank you,
Carol
Dear Carol,
Indeed MG and FBZ, in general target different mechanism. However there is one aspect that connects the two: it has been shown that FBZ may deplete glutathione depletion https://www.ncbi.nlm.nih.gov/pubmed/22048645 and it is known that Methylglyoxal is detoxified by glutathione. Therefore, combining the two will lead to higher accumulation of MG and will possibly kill tumor cells at a lower dose. But it may also be that there will be side effects at a lower dose compared to the one discussed and used in India. So if I would combine the two, I would move step by step towards the target dose.
Have you seen these articles allready:
1. https://www.cancertreatmentsresearch.com/a-visitor-story-healing-from-stage-4-prostate-cancer-with-fasting-and-juicing/
2. https://www.cancertreatmentsresearch.com/prostate-cancer/
3. https://www.cancertreatmentsresearch.com/community/prostate-cancer/
Specifically, I think it may be a good idea to read these two:
– https://www.cancertreatmentsresearch.com/community/prostate-cancer/a-treatment-that-may-save-androgen-independent-prostate-cancer-patinets/
– https://www.cancertreatmentsresearch.com/community/prostate-cancer/cholera-vaccine-reduces-the-risk-of-death-in-prostate-cancer-patients/
And I expect this will have high relevance in prostate cancer https://www.cancertreatmentsresearch.com/cholesterol-lowering-statin-drugs-to-fight-cancer/
In addition, Shanti, one of our friend and active contributors here has a lot of knowledge on Prostate Cancer – so you may want to address some questions to her too.
Kind regards,
Daniel
Hi Daniel,
Thank you for your wonderful reply and the wealth of information. I have spent this afternoon reading through the links. I didn’t know that Fenbendazole affected glutathione levels (the actual dose he takes per day is .8 of a gram). We learned about Fenbendazole here on your website from a friend and this drug interrupted cachexia for him in late June. He now has a good appetite and energy as of this date, although quite thin.
Of all this information, as complex a topic this is…I see we may want to consider adding Zoledronic Acid and Perhexiline as he is currently on Enzalutamide. Don’s story is much like ours, although my husband avoided a biopsy and surgery, already with mets to the bone at diagnosis. He has done Gerson therapy for 4 years and juicing is still a way of life. Recently added Budwig for breakfast, really has helped constitutionally. Many supplements daily, I found each has research shown to lower PSA, but w/o androgen blockers, PSA will still double bi-weekly. We’ve had good control but looking to have better results targeting mets and stem cells long term. I will continue to read and study this material and will reach out to Shanti.
Thank you again for your reply and providing this website!
Carol
Dear Carol,
Thank you for the info and kind words. Great to hear that wasting was interrupted by Fenbendazole! Another one that may help on this line is Hydrazine https://www.cancertreatmentsresearch.com/addressing-gluconeogenesis/ If there are other questions, we will try to help as much as we can.
Kind regards,
Daniel
Hi Carol,
I am sorry to hear about your husband, I know how stressful it can be to see the PSA going up. Is your husband taking Zytiga or Xtandi? Has he done any chemo yet? Where are the Mets located and what I his current PSA and PSA doubling time? All of this in formation would be helpful but here are some thoughts:
• If your husbands PSA is progressing and he is on Zytiga or Xtandi (or one of the other androgen receptor blockers), now is the window of opportunity for Provenge before chemo is tried and there are too many active mets.
• If your husband is on Zytiga, he is likely taking prednisone with it, switching to dexamethasone may resensitize him to and allow him to get more mileage out of the Zytiga: https://www.ncbi.nlm.nih.gov/pubmed/30099821, https://oncology.medicinematters.com/castration-resistant-prostate-cancer/dexamethasone/steroid-switching-may-benefit-mcrpc-patients-who-progress-on-abi/16095822
• Adding the NSAID Indomethacin to Zytiga (Abiraterone) or Xtandi (Enzalutamide) may extend the time to resistance, I would also try it for resensitization: https://mct.aacrjournals.org/content/molcanther/16/1/35.full.pdf, https://www.urotoday.com/conference-highlights/asco-gu-2018/asco-gu-2018-prostate-cancer/101841-asco-gu-2018-a-phase-ib-ii-trial-of-indomethacin-and-enzalutamide-to-treat-castration-resistant-prostate-cancer.html
• Daniel provided a link to a case study where Cabergoline, a medication that lowers prolactin was used, to overcome ADT resistance and induce remission in a castrate resistant individual. They were also using Clioquinol Cream to restore zinc in the prostate cancer cells. Dr. George Yu in Annapolis, MD is actively using this approach. We have used clioquinol cream ourselves.
• Radium-225 can be a consideration if only bone mets are present
• Have you had genetic testing for both the tumor genetics and your husbands overall genetics? For example a BRACA mutation, PDL1 or Microsatellite instability can increase the chances that the tumor will respond to one of the immunotherapy drugs out there, and can also predict which chemo he will respond to. It is well worth testing if you haven’t.
• Targeted radiation (SBRT) can be used if the mets are minimal in number
• Finally, there are some exciting clinical trials out there, some of the trials that are most exciting right now are on Lutetium-177 and it could be worth seeing if your husband qualifies for any of them: https://clinicaltrials.gov/ct2/results?cond=prostate+cancer&term=lu-177&cntry=US&state=&city=&dist= . Lutetium is a radionucleotide that is bound to a membrane antigen called PSMA and delivers a targeted radiation dose to the prostate cancer in both bone and soft-tissue. It has relatively few side effects. I know of quite a few men that are traveling to Germany or Australia for Lu-177 treatment, either because they didn’t qualify for a trial here in the US or because they didn’t want to risk being in the non-intervention arm. Some of them have gotten outstanding results and others it was not as successful, but there are several studies on Lu-177 so you can see response rates. Actinium-225 is another radio isotope that is promising and very powerful, but does come with more risk than Lutetium to the salivary glands and kidney. Actinium appears to be especially useful for when there are diffuse mets in the bone marrow.
All of the information from D on this website, especially in the prostate cancer section is also highly relevant. I also find the supplements HCA and ALA to be highly relevant to prostate cancer and they are easy to obtain, you can read more about them here: https://www.cancertreatmentsresearch.com/another-weak-spot-of-many-cancer-cells-atp-citrate-lyase-inhibition/.
I know I have given a lot of info above, so please feel free to ask more detail about any portion you are particularly interested in.
My best to you, Shanti
Hi Shanti,
We have stayed away from most conventional treatments for the past four years, except Firmagon and then had to add Xtandi last August. Used Gerson Therapy throughout and this summer added Budwig and Fenbendazole.
Our oncologist is great, he works with us and provides bi-weekly blood tests. My husband has charted everything. ADT is tough on a man’s body, takes away muscle and rising PSA would take away his appetite so he’s experienced much weight loss that is hard to build up again. We’ve even been on the edge of cachexia at times. Fenbendazole has helped with returning appetite and energy, he gets pretty tired still at times and short naps and good rest is very important. Fasting from 5pm until 9am is his daily routine with two meals and juicing.
We have added many more supplements to the Gerson routine as well plus a low-dose aspirin. He seems to have occasional herxheimer reaction symptoms, so those days require more rest. He is active most days and works on things physically. He is very sensitive to drugs. His doctor wrote a script so we could try to add Metformin and a statin, but didn’t work too well, made him pretty sick. He’s not taking those now, or Berberine. Fortunately, Fenbendazole has dropped his fasting blood sugar into the normal range from 130 earlier this summer to 98-109 average now.
I would rate his condition as uncertain and not strong, so we are looking for other therapies to add that don’t have bad side effects or negatively impact quality of life. We’ve seen that Fenbendazole doesn’t stop PSA rise recently, as intermittent Firmagon wore off this past month and in two weeks PSA doubled. Otherwise he feels optimistic and enjoys his life, hoping that what we are doing (self-directed up to this point) is the right path.
We have been considering adding IVC, using a lower dose at a long interval to really stress the cancer cells. Perhaps 25 grams over a 6 or 8 hour period, twice a week as we have a willing integrative doctor nearby. I read somewhere that high doses given quickly are not as effective. Was it Dr. Rath that recommended 10 grams over 10 hours? I am unable to find that, it seems the article has been taken down.
That’s quite a bit of detail, except for the long list of supplements he takes. We tend to take things slowly, adding one thing at a time so we can judge the results and not make a mistake. My husband calls himself “Lab Rat #00001”.
Thank you for all the information, Shanti! We look at everything and you have certainly provided other options to consider.
Carol
Hi Carol,
I can empathize with your husband’s sensitivity to medication, mine is also in that same boat. When he was diagnosed as IV immediately after prostatectomy (mets to lymph, lung and sacrum), he started Trelstar (similar to Lupron) and Zyitiga/Xgiva/Prednistone, which he struggled through for a year. Fortunately, he had a very good response with PSA <0.006, but QOL was poor and it was hard to do anything more than sit on the couch. For this reason my husband opted to do intermittent ADT, even though the ramification of that choice are unknown. Hubby is mostly raw vegan, lots of vegetable juicing, water fast 1 day per week. He takes quite a few supplements. We have at times done IVC with ozone, fasting, artemisinin, and hyperthermia. We are attempting off label meds, there are quite a few I would like to introduce, but he reacts poorly to many, fenbendazole as well. If you find anything you think is particularly effective, please let me know. We put together a plan based on this paper: The Metabolic Phenotype of Prostate Cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474672/ and this is the regimen we are working towards: https://www.cancertreatmentsresearch.com/prostate-cancer/#comment-8625 we have also added sulforaphane/DIM.
My husband has been off of all meds for over a year now with a PSA of <0.006 for most of that time. His PSA is just starting to show again and was 0.051 in Aug. Our oncologist would like to start him on ADT again when the PSA gets to 1. We are actively investigating using Lutetium-177 as an early intervention to prolong the period he is able to remain off of ADT. Lu-177 has relatively few side effects (both short and long term) and it is not an ongoing treatment, so we figure that even if hubby doesn’t feel well because of it, it is a “this too shall pass” situation instead of something he is expected to be on the rest of his life. Unfortunately, it is not available in the US outside of clinical trial for MCRPC, so we are considering Germany, Australia or India once his PSA gets up to an actionable level and we have avidity on a Ga68-PSMA scan. Here is the first published data on early intervention with Lu-177: Early Treatment of Advanced Prostate Cancer with PSMA-Targeted Radioligand Therapy Prolongs Life http://jnm.snmjournals.org/content/59/supplement_1/529.abstract?sid=a878bb92-df9c-41de-8c4a-612d97cef239. Here is a paper showing that it is more efficacious and has fewer side effects as third line treatment for MCRPC than chemo or novel ADT: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5787223/. I was also able to speak with some experts on Lu-177 at a prostate cancer conference (PCRI) this last month and was encouraged by their view of LU-177 as an appropriate and effective first line treatment, and their experiences treating select patients this way. Anyhow, this is our plan if/when PSA goes up. In the meantime, we are trying to hold it down with plan linked to above.
Best to you, Shanti
Hi Shanti,
We are working down your wonderful list of protocol suggestions. HCA and ALA has been very helpful and have seen improvement in QOL and this week we have two ALA IVs scheduled and the compounded LDN prescription will arrive. The Indomethacin is definitely worth a try if we can get another prescription from our helpful Osteopath.
I asked Daniel to send you my personal email address if you would like to correspond on the more finite details.
Thank you for all of your time and help!
Carol
Hi Carol-
I’m glad to hear that QOL has improved and I hope you continue to with good results. I will send you an email and am happy to correspond that way if you wish.
Best,
Shanti
Prostate cancer isn’t particularly glycolytic, but it does overexpress GLO1:
https://www.ncbi.nlm.nih.gov/pubmed/29504694
https://www.proteinatlas.org/ENSG00000124767-GLO1/pathology
I also saw that methylglyoxal inhibits mitochondrial complex 1.
We are considering using this on a rotational basis, maybe 2-4 weeks every few months, would that make sense? Do you know if it is stable in the fridge?
I would only use the homeopathic version given the very good condition of your husband and all the other treatment options you have. The MG solution can be stored at 2-8C according to Sigma Aldrich.
Kind regards,
Daniel
Hi Shanti,
I have posted about my Prostate cancer today on3rd Feb 2020. My case is of cancer coming back after 5 years.
Although I am regularly following up with my Uro Oncologist , but I recently met Dr.Manju Ray and started taking MG about a week back. I am still in a very early stage with PSA at 1.9 but I want to arrest the rising PSA which might cause trouble in future.
Do you think MG given by Dr.Manju Ray will help me. Will appreciate your reply.
hey santosh,
i am from rajasthan
where did you met dr manju ray.
i need to contact her, can i talk to you over phone if dont mind ?
Hi Shanti,
Thanks for your reply.
I am much relieved to read your reply suggesting various options.
I will take a printout of your reply and discuss with my Uro Oncologist. I live in Delhi and I hope they have these procedures here.
After my surgery, biopsy suggested that all my margins were Clear except one Apical margin was Positive.
After surgery I was given after 1.5 years radiation and a single dose of Eligard hormone injection affective for 6 months.
Than I saw Dr. Charles Myres in USA who stopped any further Hormone as my PSA came down to 0.003.
He put me on controlled diet along with many supplements.
As I am in very early stage I am really tried hard to control rise of PSA. In whole of 2019 I was able to hold my PSA at 1.0 by taking some homeopathy and Ayurveda.
In mid of November 2019, I had to rush to USA as my son met with a serious car accident. While in USA I couldn’t control my diet with Thanksgiving and Cristamas festival during that time. Also I could not take my Ayurveda and Homeopathy medicines properly. So when I returned to New Delhi my PSA shot up to 1.9.
I am meeting a doctor today who does this Dendritic cell therapy. I am not sure about effectiveness of this therapy.But want to explore. Any idea about this Dendritic cell therapy.
I also take a lot of supplements Resvertrol , Pom juice, vitamin C, Omega 3, curcumin more than 2 grams per day. Lecithin, calcium, vitamin K and D. Some I buy from Life Extension and some from Amazon.
Nice of you to have replied promptly.
Thanks and warm regards
Santosh
Hi Kuldeep,
I am not sure if I am permitted to put my contact details here.
But you can do a google search for DR. MANJU RAY. She is with Bose institute Kolkata.
Right now she is in Kolkata . She is leaving for Pune on 7th.
Or you can send a message to me on messenger using my name.
Regards
Santosh
Hi Santosh,
It certainly seems the MG has the potential to help, but we never tried it ourselves. From you post below, it sounds like you are going to have a PSMA PET scan done, which is great. With a PSA of 1.9, the chances are good that the scan will tell you where the cancer is. In a case like yours, the hope is that the cancer is located in a limited number of places which can be treated with a type of radiation called SBRT. Treatment of oligmetastatic (prostate cancer with limited metastasis) and/or prostate cancer that is still limited to the pelvic region with SBRT may delay progression for many years and in some cases may be curative.
Hi Shanti,
Thanks for your reply.
I am much relieved to read your reply suggesting various options.
I will take a printout of your reply and discuss with my Uro Oncologist. I live in Delhi and I hope they have these procedures here.
After my surgery, biopsy suggested that all my margins were Clear except one Apical margin was Positive.
After surgery I was given after 1.5 years radiation and a single dose of Eligard hormone injection affective for 6 months.
Than I saw Dr. Charles Myres in USA who stopped any further Hormone as my PSA came down to 0.003.
He put me on controlled diet along with many supplements.
As I am in very early stage I am really tried hard to control rise of PSA. In whole of 2019 I was able to hold my PSA at 1.0 by taking some homeopathy and Ayurveda.
In mid of November 2019, I had to rush to USA as my son met with a serious car accident. While in USA I couldn’t control my diet with Thanksgiving and Cristamas festival during that time. Also I could not take my Ayurveda and Homeopathy medicines properly. So when I returned to New Delhi my PSA shot up to 1.9.
I am meeting a doctor today who does this Dendritic cell therapy. I am not sure about effectiveness of this therapy.But want to explore. Any idea about this Dendritic cell therapy.
I also take a lot of supplements Resvertrol , Pom juice, vitamin C, Omega 3, curcumin more than 2 grams per day. Lecithin, calcium, vitamin K and D. Some I buy from Life Extension and some from Amazon.
Nice of you to have replied promptly.
Thanks and warm regards
Santosh
Dear Santosh,
Please see this video on treating oligometastatic prostate cancer by Dr. Eugene Kwon: https://www.youtube.com/watch?v=NkqizmvqJPo
Also, here are some studies to share with you oncologist on oligometastatic prostate cancer treatment, if your PSMA scan indicates that is what you have. Basically SBRT may delay disease progression and there have been some documented cases of long-term, and even over 5 year remission.
https://euoncology.europeanurology.com/article/S2588-9311(18)30044-0/fulltext
https://www.astro.org/News-and-Publications/News-and-Media-Center/News-Releases/2019/Trial-reports-randomized-evidence-high-dose-radiat
https://www.medscape.com/viewarticle/903693?src=wnl_edit_tpal&uac=218029MJ&impID=1774720&faf=1#vp_2
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5154616/
Is the dendritic vaccine you are considering the APCEDEN vaccine? It is not available in the US, but I have been in touch with someone on a prostate cancer forum who reports that it benefited him greatly. Here is a thread where he tells his experience: https://healthunlocked.com/advanced-prostate-cancer/posts/142507346/substantial-remission-of-prostate-adenocarcinoma-with-dendritic-cell-therapy-apceden%C2%AE-in-combination-with-chemotherapy-29-oct-2019. He had it done in Delhi.
Thank you so much Shanti,
I will discuss with my doctor what kind of treatment he is considering in Dendritic cell therapy
APCEDEN or some thing else.
Last time I asked him that since I was operated in August 2011 and they did not preserve a piece of my malignant Prostate so how will they prepare vaccine. To which he replied that they have a bank for that from which they will prepare vaccine and it be like 90 to 95 % as compared to your own vaccine.
I will read the links you have sent.
As you have gone through so much treating your husband you have so much knowledge which you are able to pass it on to others.
I am 68 and if I can get another 10 to 15 I will be pretty happy.
Warm regards
Santosh
Hi Shanti,
Your link on Oligometastatic Prostate cancer is very enlightening. Dr.kwon has explained it so well with video slides of each of his patient.
After seeing that Link I am thinking of meeting my Uro Oncologist again and get the PSMA Pet scan done now itself rather than waiting for 3 more months.
My last PSMA scan over a year back showed nothing though. But at that time my PSA was 0.7 I think.
Thanks once again
Santosh
Hi Santosh- There are so many treatments available now for prostate cancer. Of course, no one wants to be on anti-androgen therapy, but if it is needed between hormone therapy, chemo, immunotherapy, Provenge, and now radioligand therapy, men are living many years longer than they used to. When you combine these with some of the great therapies on this site, your chances for good results go up. Please keep us posted on the results of your PSMA scan.
Hi Shanti,
Last few days was busy visiting doctors. My PSMA test came out negative. Which means they could not see any hot spot or locate any cancer. So I took opinion of two more doctors . One name I got from the prostate cancer forum link that you had sent to me. One person from USA goes to Dr.Ashok Vaid at Medanta hospital in Gurgaon near Delhi for his Dendritic cell therapy. As Dr.Ashok was away on leave I met his 2nd senior most doctor from his team. She advised me to start hormone.
My regular doctor and one more doctor I met who also does Dendritic cell therapy asked me to wait for another 3 months and come back with a fresh PSA report.
I got 3 more months grace period now. I really want to avoid taking hormones until absolutely necessary.
From your experience what are my best options as doctors don’t discuss various options with patient here. Their standard reply is we will see when we reach there.
I think in my case it’s too early for Dendritic cell therapy.
Luckily I got samples of my prostate Tissues from my surgery in 2011 which they preserve for 10 years.. They would have destroyed them next year. But I collected and kept with me.
Recently I heard from a friend about Proton laser therapy and 2DG therapy. Any idea about that.
Looking forward to your advice.
Warm regards
Santosh
Hi Santosh,
Looking at your past posts, it looks like your PSA a year ago was 0.7 and now it is 1.9, so your doubling time is a little less than a year, which indicates that the cancer is not particularly fast growing. At a PSA of 1.9, most people will show activity on a PSMA scan. Yours may not show because the mets are more diffuse and smaller, or because about 5-10% of prostate cancer doesn’t express PSMA. You might consider an Axumin (fluciclovine F18) PET scan to make sure something isn’t being missed. The idea of using SBRT to treat solitary lesions that show up is appealing, but if nothing is showing, it can’t be done. You asked about Proton Laser therapy, the idea is similar to SBRT, but you need to be able to see the lesions on imaging in order to target them, also SBRT has much more research for metastatic disease, so I would stick with SBRT.
With regards to starting hormones, as the PSA goes up, doctors get more nervous. Higher PSA correlates with more cancer activity and it is also thought that having more cancer means that there is more potential for mutations, leading to more aggressive disease. When men are doing intermittent hormone therapy (when you come off and then go back on again), most doctors use a cut-off PSA of 5 as the threshold to reinitiate hormones. You are certainly below that threshold now.
From a conventional standpoint your options are:
• Wait and see if you can get a positive PSMA or Axumin scan to target individual metastatic lesions
• Start hormone therapy and consider using it intermittently
• Chemotherapy with docetaxel is also on the table, but usually doctors will want a positive PET before utilizing this option. The chemo regimen used for prostate cancer is generally well tolerated.
Other considerations:
• Early treatment with Lutetium 177 (but you need a positive PSMA scan to consider this)
• Immunotherapy- you would want to have your cancer cells evaluated for PDL1/2, MSI, BRACA1/2 and potentially other mutations to see if you carry any targetable mutations. Guardant360 is a liquid biopsy (they test your circulating tumor cells) that is used here in the states to look for such mutations. Immunotherapies are typically not used unless the person has failed androgen deprivation, but if you test positive for a targetable mutation, read up on it and decide you want to treat that way instead of ADT, your doctor may work with you.
• Metabolic therapy, such as those discussed on this site. 2DG is part of a metabolic approach to cancer and blocks sugar metabolism in cancer cells. It needs to be given continuously and best via IV. Also keep in mind that prostate cancer is not highly glycolytic (sugar eating), but prefers fat, at least until late stage. Since May 2019 we have watched mu husbands PSA increase with a doubling time of about 2 months. However, in June 2019 and again in Feb 2020, his PSA did not increase. What did we do differently for those two months? He used topical clioquinol cream. https://www.cancertreatmentsresearch.com/unlocking-zincs-potential-to-fight-cancer/#comment-8610. We can’t be 100% certain, but it may be stabilizing his PSA. The cream makes him feel poorly, so we only used it 1 week the first time and 3 days the second time. We are going to try it again this month at a lower dose.
• Here is another interesting paper on the benefit of the cholera vaccine Dukaral for prostate cancer: https://www.nature.com/articles/s41467-018-04814-4. Have you had the vaccine? We had a friend from Canada send it to us my husband is going to take it tonight.
• We also have seen benefit in PSA values from Sulforaphane. We are taking 3 tablets per day of Life Extensions Optimized Broccoli which has about 12mg of sulforaphane per tablet.
• If you want to see some of the meds/sups I initially considered for metabolic therapy for my husband, you can take a look here: https://www.cancertreatmentsresearch.com/prostate-cancer/#comment-8625. It may help you as you consider your own regimen if you decide to try that.
Best,
Shanti
Hi Shanti,
Thanks for your detailed reply with various options.
One more thing I want to ask. After getting a negative PSMA report one of the three doctors I met said he will like to do a PanTum blood test after 3 months to detect any cancer cell in body.
Have you heard of this test and do you think I need it as I already have prostate cancer.
Thanks
Santosh
Hi shanti,
I searched for Dukaral. I found here in India we have DUCORAL which comes in 2 sachets in powder form. It has to be mixed with water and taken.
Is this DUCORAL same as DUCARAL. Just O in place of A. And how do you take it ?
Also what you are having is in powder form in sachet or an injectable vaccine.
Thanks and regards.
Santosh
Hi Santosh-
I agree, I don’t see the a reason to have a test to detect cancer when you already know you have it. Better would be a test for circulating tumor cells with genetic analysis.
Best,
Shanti
Hi Santosh, Sorry for the confusion, the correct spelling is Dukoral. If you are seeing Ducoral and it is an oral cholera vaccine, i’m sure it is the same. It is an oral vaccine and a box comes with two doses, to be taken 1-6 weeks apart (your preference). Each dose has a sachet and a small vile. The sachet contains a buffering powder and is put in water and then the vaccine in the vile is added to that, then down the hatch! My husband took his first dose on Thursday with now issues.
We have also experimented a lot with supplements. As it stands now, of what he takes, I think sulforaphane has had the biggest impact in slowing PSA progression. I am a proponent of repurposed meds for cancer use, but my husband has a sensitive system and has not been able to use many of them. However, we think that clioquinol cream along with supplemented zinc may have made a difference: https://www.cancertreatmentsresearch.com/unlocking-zincs-potential-to-fight-cancer/#comment-8610.
Hi Santosh,
Can you please share your experience of using MG ?
Thanks,
Vishwa
Hi D,
Thanks for your helpful replies, I agree with the notion of using this when other treatments fail. I have backup plans for my backup plans, going for several layers! We have not run the gamut of convention treatment, ADT, SBRT, chemotherapy, immunotherapies, and radioactive isotopes, but sure would like to control the cancer metabolically or delay these treatments if possible.
Warmly,
Shanti
Hi All,
This is an extremely interesting article ; There is something I dont understand : A well know researcher, with no questionable integrity got a impressive response rate on various tumor type in a clinical trial over 100 patients more than 10 years ago and nothing happens ? Why ?
By the way, the link to the 86 patient’s trial is dead.
Julien
This MD explains it well IMO:https://youtu.be/mAGhNhrHMJs?t=559
Hi All,
looks like very interesting web Page to interact on cancer issues.
I was diagnosed with prostate cancer and operated by robotic surgery in August 2011. Than underwent Radiation therapy in December 2012 along with 6 month dose of hormone injection . After this my PSA became undetectable @ 0.003.By end 2017 it started rising and in 2018 when it crossed 0.2 my doctor confirmed that cancer is back.
At present my PSA is 1.9. My doctor wants to do a CDMA pet scan after 3 months when he will decide further action may be hormone to start again.
In the mean time I met Dr.Manju Ray and she advised me to start taking MG 4 times a day along with vitamin C and B complex.
I am otherwise health like a normal person except rising PSA which might cause trouble in future if it Metastases.
I want to arrest this rising PSA right now.
Do you think MG given by Manju Ray will help. I started taking it just a week back.
Hi Santosh,
Welcome! Whats is the dose of MG you are taking and what Dr.Ray said you should avoid while using MG (if any)?
I will think during the next days, what would be other elements I would consider in parallel, and let you know.
Kind regards,
Daniel
Hi D,
Thanks for your reply.
She did not tell me the dose in mgs . She calls it 8X.. Now what is this 8X she only knows. She has asked me to take 500 mg of Vitamin C after every dose of MG.
I am supposed to take MG 4 times a day at 8, 12, 5pm and 10pm with some fruit juice ( non citrus). Also take Multi Vitamin tablet twice a day
My cancer has not yet spread. My Uro oncologist did a PSMA Pet scan last year which was normal. So he did not prescribe any medicine as yet. Wait and watch. I will do PSA after 3 months along with a PSMA Pet scan. Based on results he might prescribe hormonal treatment which I want to avoid as long as possible due to side affects.
I am not sure if I will be able to continue taking MG as it makes me nauseated and sick.
My digestive system is very sensitive and I get too much of acidity and nauseous whole day.
I know a few of Dr.Rays patients who are taking MG without much problem. At least they say so. I called Dr.Ray yesterday and she asked me to take Pantaprazole every morning empty stomach to control acidity. Which I did but not much relief.
She asked me to avoid citrus fruits and spicy food.
During whole of last year I also took some homeopathy and Ayurveda medicines and my PSA was stable @ 1.0 for whole of 2019.
Around middle of November I has to rush to USA as my son met with a car accident. During my stay in USA for 2.5 months I could not control my diet nor took homeopathy and Ayurveda medicines properly. As a result when I came back about 10 days back my PSA went up to 1.9 from 1.0 three moths back. It’s when I contacted Dr.Ray and started MG.
Regards
Santosh
Dear Santosh-If the MG is labeled as 8X it is likely that it is a homeopathic preparation: http://www.homeopathichealing.org/x-c-and-m-the-alphabet-of-homeopathic-potency.html
Hi Shanti,
Thanks for the information.
About 3 months back I met Dr.Manju Ray and she gave me 2.5X as she told me that I don’t have cancer as she did not believe in PSA alone.
Actually she is an old lady and could not understand my case. But later when she saw my biopsy report she said that I do have prostate cancer and I will need higher dose of 8X.
As I had to leave for USA immediately after that so I could not start MG. After coming back when I saw PSA jumping from 1.0 to 1.9 I contacted her and she gave me 8X.
Your link says X represent dilution of 1:10. If it was so dilution of 1:2.5 should be stronger dose.
I think 2.5 could be 1:25. I think she only knows better.
Regards
SANTOSH
well….. the thing about homeopathy, as odd as it sounds, is that the more dilute a substance, the more potent the remedy is considered. See points 13 and 14: https://www.hahnemannlabs.com/homeopathy.html
“As the remedies are potentized through serial dilution and succussion, their strength or potency is increased, not decreased. For example, the 30C is a higher potency than the 6C”
Hi Shanti,
It has been long time since we communicated. COVID-19 has changed everything upside down.
No body knew such thing can happen.
Well I was stuck in Bangkok Thailand for 11 months. Just came back to Delhi . My PSA rose from 1.9 in Fenruary 2020 to 2.3 than to 2.8 and now on 11th February 2021 it rose to 3.66. Another PSMA done 2 days back also can’t detect any tumour. Compared to earlier tests done in February 2020 and July 2018 this PSMA is exact repeat of the earlier ones.
Normally any doctor will go for hormone therapy . But I am a bit scared. My doctor looking at my slow progression rate and clear PSMA and my Gleason 3+3=6 wants to wait another 6 months.
What do you think. Any suggestions looking at your experience in dealing with this disease.
Hi Santosh,
Nice to hear from you. I can sympathize with your predicament. Although your PSA has a relatively slow rise, the fact that it is even present indicates that the cancer has returned, either more locally in the prostate bed or pelvic region, or more distantly, possibly in the lymph nodes outside the pelvis or in bone. Unfortunately, even with a PSA of 3.66, you are not getting a read with the PSMA PET scan. The advantage of waiting 6 months for another PSMA scan is that you may be able to detect the cancer and treat it with SBRT (if there are relatively few spots) or early Lu-177 intervention (two friends of mine just had Lu-177 done in Delhi with very good results) and possibly delay hormone therapy. The disadvantage is that waiting while an unchecked PSA increases means you run the risk of additional metastasis and spread. Here are some additional thoughts:
• Not all prostate cancer expresses PSMA, consider an AXUMIN PET scan to make sure you aren’t missing anything (https://www.thno.org/v10p6082.htm)
• You could consider trying off label meds, we had some success with 2 grams of 3% clioquinol cream and 100mg of zinc daily (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392423/). If you try this or other approaches you would want to test monthly to see if it is having an impact on PSA. If PSA does not respond, you would want to initiate a more proven therapy. You can add to this some of the supplements that can be helpful. Daniel carries a very potent Sulforaphane supplement https://www.mcsformulas.com/en/vitamins-supplements/broccoli-sulforaphane-ultra66/. Sulforaphane has some of the strongest research on prostate cancer and I consider it important for anyone in the battle. Also consider green tea and curcumin and other polyphenols.
• You could consider 6 months to one year of hormone therapy as an intermittent ADT approach
Obviously, this is a very personal decision, but for me, I would not wait without action as it can allow the cancer to get more of a foothold.
Wishing you the best!
Hi Shanti,
Thanks for your prompt reply.
You said two of your friends got Lu-177 intervention done in Delhi.
So can you please find out the name of the Doctor/Oncologist or hospital under whom this treatment was given as I can also consult him.
Also you mentioned about 2 grams of 3% clioquinol cream and 100mg of zinc daily. Please let me know how do I take this cream with zinc, I mean orally.
I will consider other options mentioned by you like 6 months of hormone therapy.
Thanks once again for your suggestion and help.
Regards
Santosh
Hi Shanti,
My last communication with you was in February 2021 when my PSA was 3.66 and still PSMA scan was showing nothing.
Now in July 2021 my PSA shot up to 8.75 just in 4 months. My doctor ordered another PSMA pet scan. Now finally my PSMA has picked up a spot. The conclusion of the report is :
PSMA AVID NODAL LESION SEEN AT THE LEVEL JUST PROXIMAL TOTHE BIFURCATION OF RIGHT COMMON ILIAC VEIN. IN VIEW OF RISING PSA THIS LESION IS HIGHLY SUSPICIOUS OF RESIDUAL/RECURRENT DISEASE IN COMPARISON TO THE LAST PSMA SCAN DATED 9-2-2021.
NO DEFINITE EVIDENCE OF ABNORMAL PSMA EXPRESSING DISEASE NOTED ELSEWHERE IN THE REGION OF BODY SURVEYED WITH REST OF THE SCAN FINDINGS DESCRIBED ABOVE.
SHANTI now I have a single spot near Bifurcation of Right common iliac vein. This vein is in lower abdomen as checked by me on Google search.
Now I met two doctors to take second opinion.
1. First doctor suggested as the spot is less than 1 centimetre , if they do radiation they might miss the spot
So he is suggesting hormones. But they uploaded my PSMA CD and reports in their system and a team of
Radiation Oncologists with review and discuss my case and let me know about radion option. This is the
biggest cancer hospital in Delhi Rajiv Gandhi cancer hospital.
2. Next I met yesterday Dr.Ashok Vaisya of Medanta hospital. He is considered top medical oncologist in Delhi and many people from USA have taken stem cell or Dentric cell therapy from him as I read on some other cancer forum. He gave 3 options to me to decide
A) Radiation
B) Hormone
C) Surgery
In case of surgery doctor said we will remove the tumour by surgery and make injection from the tumour removed or preserve it for future Stem cell therapy if needed.
Now the doctor gave three option but refused to recommend which one will be the best suited for me. He left it to us to make a decision in next few days.
This is real confusing for me. In your earlier post you had said that these days they do radiation once a spot if found in the PSMA. You had also given a link for this of video of Dr.Eugene Kwon recommending radiation.
In case of Surgery the advantage may be that I will have tumour sample for future Sten Cell therapy.
As you have so much of experience and have gone thru various treatments for your husband can to help me in deciding the best option for me. I will be looking forward to your reply as I have to decide in next week or so.
Thanks again for your concern and helping me decide to fight this disease.
Best regards
Santosh
2
Hi Shanti,
Thanks for the reference to zinc and prostate cancer. I hadn’t seen that before. I was wondering if you were using zinc dipicolinate by any chance. There is some speculation that this might enter the prostate cancer cells without the aid of clioquinol. Since the clioquinol topical absorption is an open question, perhaps it’s just a placebo?
https://jcmtjournal.com/article/view/3560
Also, there are other zinc ionophores like ECGC and Quercetin that might be useful substitutes taken systemically
https://www.frontiersin.org/articles/10.3389/fimmu.2020.01712/full
all speculation on my part
thanks so much for your contributions on prostate cancer!
We used zinc monomethionine and citrate. I don’t see zinc dipicolinate on the market for purchase, but if you have a source, please share, I would probably switch to it in conjunction with the clioquinol. Please let me know where you are seeing that it is speculation that clioquinol is absorbed. Here is information in its absorption:
https://pubmed.ncbi.nlm.nih.gov/157893/
https://pubchem.ncbi.nlm.nih.gov/compound/Clioquinol#section=Absorption-Distribution-and-Excretion
My husband does notice that he feels differently when he uses the clioquinol cream, which has actually limited oru ability to use it. Zinc alone, even at high doses does not appear to be able to significantly impact metastasized prostate cancer, probably because of the transport issue. I think it is great to add green tea (EGCG) and quercetin to a regimen, but we did not find that they were strong enough along with the zinc to impact PSA levels.
Great article btw, I just read it. It actually looks like zinc picolinate and zinc dipicolinate are the same thing and zinc picolinate is readily available. Maybe this could really help the efficacy of the clioquinol, or maybe have more of an impact when taken alone. Anyhow, thanks for posting, this may be a great help to us.
Hi Shanti,
My apologies for my post being unclear. I was on day three of a 3 day fast and the brain wasn’t fully functional. When I wrote speculative I was referring to other Zinc ionophores such as ECGC being effective in transporting zinc into prostate cancer cells. That was total speculation on my part.
Regarding the absorption of clioquinol, the cutaneous absorption is one or two orders of magnitude lower than the oral bioavailability. All the tests I saw used effective doses much higher than the amount absorbed cutaneously, so an alternative way to get the zinc into tumor cells would be nice to have.
thanks again, John
Hi Shanti,
Thanks for your prompt reply.
You said two of your friends got Lu-177 intervention done in Delhi.
So can you please find out the name of the Doctor/Oncologist or hospital under whom this treatment was given as I can also consult him.
Also you mentioned about 2 grams of 3% clioquinol cream and 100mg of zinc daily. Please let me know how do I take this cream with zinc, I mean orally.
I will consider other options mentioned by you like 6 months of hormone therapy.
Thanks once again for your suggestion and help.
Regards
Santosh
Hi Santosh,
The hospital was Santosh Memorial Hospital and the doctor was Dr. Ishita Sen. You can read about their experiences here: https://healthunlocked.com/advanced-prostate-cancer/posts/145267477/excellent-response-lu177-new-delhi-india.
Regarding the clioquinol and zinc:
Clioquinol 3% cream -1g twice a day applied to the skin- we used inner arm/wrist and back of knees, upper chest. (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392423/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6578577/)
zinc -50mg twice a day orally
see also:
Evidence that Human Prostate Cancer is a ZIP1-Deficient Malignancy that could be Effectively Treated with a Zinc Ionophore (Clioquinol) Approach (2015)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4531383/
Zinc Ionophore (Clioquinol) Inhibition of Human ZIP1-Deficient Prostate Tumor Growth in the Mouse Ectopic Xenograft Model: A Zinc Approach for the Efficacious Treatment of Prostate Cancer (2016)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4751054/
A Proposed Efficacious Treatment with Clioquinol (Zinc Ionophore) and Cabergoline (Prolactin Dopamine Agonist) for the Treatment of Terminal Androgen-independent Prostate Cancer. Why and How? (2019)
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392423/
Best to you,
Shanti
Hi Shanti,
Thanks for the information. In fact after reading your last reply about Lu-177 I searched on the net about hospitals in Delhi giving this treatment. I found there are two hospital, Fortis Memorial and Rajiv Gandhi cancer hospital.
So I called Fortis Memorial Lu-177 center and found Dr.Ishita Sen on the line ( same doctor you have mentioned now). I explained her my history and present PSA levels and PSMA results. It turned out that Dr.Yadav who is the head of this division was a part of Surgery team which did my Robotic Prostate surgery in August, 2011 in Medanta hospital.
Dr.Ishita Sen told me that right now I am not eligible for Lu-177 as my PSMA is not showing anything.
But in any case I will be meeting her and Dr.Yadav shortly after I am back in New Delhi from Jaipur in a few days to discuss my options.
Regarding Zinc 50mg twice a day must be an oral supplement available across the counter.
Shanti you keep giving me so many information and options for which I am really thankful. Also I am thankful to this Forum.
Warm regards
Santosh
Hi Santosh,
Yes, zinc is sold OTC as a mineral, it comes in lots of forms, I would just avoid zinc oxide as it may not be as absorbable as others. If you are not getting a read with a PSMA scan and your PSA is up significantly, you may want to do an Axumin/Fluciclovine F18 scan as not all prostate cancer expresses PSMA and you don’t want to miss something.
My best to you,
Shanti
Hi Shanti,
I forgot to tell you that I also met Dr.Ishika Sen at Fortis Memorial Hospital where 2 of your friends had taken LU -177 treatment. Dr Sen told me that in case my PSMA shows a Single Spot than she will not do LU-177. But in case Multiple spots are seen in PSMA than she will do LU-177.
So I showed her my PSMA report two days back and she said my case doesn’t warrant LU-177 treatment.
She is a fine doctors and listens to you very patiently and gave us about 1 hour when I first went and met her and discussed in detail.
May be in future I may need her , you never know.
Regards
SANTOSH.
HI Santosh,
How many ml of solution you take each day? And how is that divided during one day?
I may be able to guess the dose from that.
Kind regards,
Daniel
HinDaniel,
Sorry for late reply. I take MG 8X four times a day with fruit juice ( non citrus) . After taking this I take one vitamin C 500mg chewable tablet (every time ie.4 times). I take it at 8 am, 12 noon, 5 pm and 9pm.
Also she asked me to take multivitamin tablet twice a day.
Regards
Santosh
Hi Santosh,
Thank you. Could you please let me know how what is the quantity of MG you take each time (out of the 8x/day)? How many millilitres you take at once (or the amount of millilitres MG solution you take each day – whatever it’s easier for you to calculate)?
Kind regards,
Daniel
Hi D ,
Will wait for your recommendations to be taken in parallel.
Thanks
Santosh
santosh please check your Facebook messenger
and thanks my relative is going to meet her today!!
Hi Daniel, I am Sandeep Yadav M/44. Diagnosed with Borderline resectable Pancreatic Tumor on Head of Pancreas during 04/2019 abutting Portal Vein. Done 5 Cycles of Folfirinox and then the tumor shrunk to 1.3cm from 2cm and accordingly the Whipple procedure was done at Tata Memorial, Mumbai by Dr. Shailesh Shrikhande in Aug/2019. The biopsy report is Adenocarcinoma of Pancreas on Head T1n0m0 (Tumor size 1.3cmx0.5cmx0.5cm). No lymphnode affected & all margins clear.
7 Cycles of Folfirinox taken afterwords as Adjuant Chemo as suggested by TMH, Mumbai oncologist. And further the oncologist at Artemis Hospital Gurugram recommended 3-4 Cycles of Xeloda (1500mg/day) as mop-up Chemo keeping in view of high recurrence rate of Pancreatic Cancer however 2 CTs done after Whipple showed no metastasis/recurrence.
Now I want to start Methylglyxol as a maintenance chemo.
What do you suggest (As most of Onco Doctors don’t know about MG)? I also bought Liposomal Cellmunity Plus (https://www.letstalkhealth.com/Cellmunity-Plus-32oz) taking 20ml/day.
Please tell me ur experiences of mop-up chemo for MG i.r.o. Pancreatic Cancer. Pl also suggest any other Natural Minerals/Proteins etc which can help me to enhance immunity to prevent recurrence of PanCan.
Thanks a lot for sparing ur time in the help of cancer patients.
Dear Sandeep,
I think the best is that you go through the following information, and if you have a specific question you let me know:
1. https://www.cancertreatmentsresearch.com/summary-of-this-website/
2. https://www.cancertreatmentsresearch.com/pancreatic-cancer/ and https://www.cancertreatmentsresearch.com/alternatives-in-advanced-metastatic-pancreatic-cancer-by-ovidiu-herlea/
3. https://www.cancertreatmentsresearch.com/community/pancreatic-cancer/
I would not use the supplement you mentioned https://www.letstalkhealth.com/Cellmunity-Plus-32oz toghether with MG as it contains a strong anti-oxidant Glutathione.
In general, to try prevent recurrence, I would build a strong cocktail of anti-inflamatory supplements and re-purposed drugs such as Curcumin, Olive Leaf Extract, Black Cumin Oil, Low dose Aspirin, Cimetidine (always check interactions), Dypiridamole and immune enhancing supplements such as Vitamin D3 and mushroom extracts. High dose Vitamin C from time to time could help too. Cycles with anti parasitic drugs such as Fenbendazole and Mebendazole could help to. Please read the content on this website and you will get more ideas.
Kind regards,
Daniel
THANKS Daniel,
I appreciate quick reply and honor your time to help me.
Kindly let me know if u can help to suggest some good brands of referred anti-inflammatory drugs and potency of Low dose Aspirin so that I can buy online.
During an online search, I got a lot of brands and can’t decide which one is authentic and better. BTW I made a search in Amazon.in. Your help is really appreciated as no oncologist will suggest these things like use of low aspirin dosages, Febenazole/Mebendazole and anti inflammatory drugs and supplements.
Best Regards
Dear Daniel,
Please take a look at this study:
Methylglyoxal, a glycolysis metabolite, triggers metastasis through MEK/ERK/SMAD1 pathway activation in breast cancer
https://breast-cancer-research.biomedcentral.com/articles/10.1186/s13058-018-1095-7
Some extracts from the text:
„These results uncover for the first time the key role of MG dicarbonyl stress in the induction of ECM remodeling and the activation of migratory signaling pathways, both in favor of enhanced metastatic dissemination of breast cancer cells.“
„Recently, using breast and glioblastoma cell lines, our group has demonstrated that low doses of MG promote tumor growth rather than inhibit it. This hormesis effect of MG seemingly reconciles contrasting data in the literature [9]. In fact, at sub-toxic doses, MG turns out to be beneficial to cancer cells as they acquire resistance to apoptosis and enhanced growth properties.“
„This study improves our understanding of the connection between glycolytic switch and breast cancer aggressiveness and proposes MG scavenger molecules (such as carnosine and aminoguanidine) as potential novel treatment options in the management of metastatic breast cancer.“
Does this mean that taking Methylglyoxal for cancer (at least for breast cancer) may not be a good idea?
Thank you,
Maki
Dear Maki,
Thank you so much for sharing this paper and your related question. Indeed this is a very fair question. The authors show that MG may enable metastasis via it’s activity on the extracellular matrix. I think this is a very relevant aspect and here is how I fit this paper into my understanding, and making it as simple as possible:
1. Oxidation in cancer is a key mechanisms essential for either cancer cell death or the opposite, for tumor expansion. In order to make this a little more clear, we need to split the discussion by looking inside the tumor and outside the tumor.
2. Looking inside the tumor cells, pro-oxidants are good, anti-oxidants can be bad (there are always some exceptions but I make this statement to make things more simple). This is why chemotherapy and radiotherapy in some cases can be effective.
Here I discussed in more details this subject: https://www.cancertreatmentsresearch.com/modulating-the-yin-and-yang-energy-of-cells-to-fight-cancer-pro-oxidant-strategy/ This is the context in which MG can help fight cancer.
3. However, looking at the extracellular space, pro-oxidants are bad and anti-oxidants are good. And this is what is actually pointing out the article you shared here, as pro-oxidants can influence extracellular matrix in such a way so that the tumor can grow easier, faster and can spread easier.
Indeed, facts support the above statements as we know that pro-oxidant treatments can kill tumours but they can also lead to growth and spread of the tumors as it is sometime the case when conventional therapies are performed. This is why I think, that whatever strategy we chouse, anti-oxidant or pro-oxidant strategy, we need to act intensively. I like more the anti-oxidant approach as it is more friendly to the body but this makes more sense in the initial stage of cancer. When cancer is advanced, a more intensive approach is required, and typically the more intensive ones are of pro-oxidant nature, such as MG. In case we go for pro-oxidants, such as MG or chemo, etc., here I discussed a strategy that may help increase the chance of effectiveness https://www.cancertreatmentsresearch.com/modulating-the-yin-and-yang-energy-of-cells-to-fight-cancer-pro-oxidant-strategy/
Nevertheless, in order to avoid effects such as discussed in your paper, pro-oxidant treatments should be applied intensively and in pulses, i.e. not long term.
Kind regards,
Daniel
There’s a very recent paper published in Nature Immunology (https://doi.org/10.1038/s41590-020-0666-9) implicating methylglyoxal in suppressing CD8+ T cells in the tumor environment.
It’s probably not a good idea to use it at the same time as immunotherapy.
This is why I often point out that we need to chose our fight and be coherent with that. Based on scientific evidence MG can be a powerful one against cancer but combining with immuno-therapy may not be a good idea. Otherwise I would not be too worried about that effects since the immune system anyway is not doing it’s job if the tumours succeeded to advance.
All these treatments that are powerful enough, they typically have off targets. Same applies for immuno-therapy, for MG, chemo, radio, 3BP, etc. The point is to focus on the anti-cancer mechanisms and to combine them in a clever way with other powerful treatments that work in the same direction and not the opposite. By integrating multiple treatments we may even be able to reduce the dose of the treatments and still be effective while reducing side-effects.
Kind regards,
Daniel
Bonjour Daniel,
Je suis du Québec. Je viens de m’inscrire sur votre site. Je vous explique ce qui m’y a conduit. Mon épouse a reçu , il y a environ 2 mois, un diagnostic de cancer de l’ovaire. Tumeur de 11 cm. Elle devait subir une chirurgie le 15 octobre, mais après mûres réflexions, nous avons décidé d’un commun accord d’annuler ou de faire reporter à plus tard cette opération. Avant, nous voulions essayer “un traitement simple et non toxique” qui a donné d’excellents résultats ailleurs, approche que préconise le médecin et chercheur français Laurent Schwartz. Il y a un hic: une molécule clé dans le protocole du Dr Schwartz est le Hydroxycitrate (tiré du Garcinia Cambodgia), excellent remède mais qui fait maigrir, et mon épouse a déjà perdu assez de poids avec son cancer. Nous craignons la cachexie. Je cherche donc un traitement efficace qui n’entraîne pas de perte de poids. Il y a bien l’hydrazyne, mais c’est très contraignant (il faut éviter tout ce qui contient de la tyramine). Il y a aussi le Cesium, çà aussi, ce n’est pas simple. Beaucoup d’effets indésirables et mon épouse est fragile. En explorant votre excellent site, j’ai découvert que la créatine soutient le méthylglyoxal (une molécule d’un grand potentiel anti-cancer) et pourrait stopper le cycle de la cachexie. On dit que le méthylglyoxal est relativement facile d’accès, mais j’ai peine à trouver un fournisseur qui accepte d’en vendre à un particulier. Ce produit très peu toxique qui “devrait être utilisé au profit de l’humanité souffrante”,Sigma ne le vend qu’aux laboratoires et aux universités, et chez l’autre fournisseur du scbt.com, il est trois fois plus dispendieux et n’est offert qu’à des fins de recherche. Je n’ai pas lu tout sur votre site à propos du méthylglyoxal. Si je ne peux me le procurer, pourriez-vous me mettre sur la piste pour d’autres protocoles qui pourraient répondre à nos attentes. Merci
Jacques
Google translation:
Hello Daniel,
I am from Quebec. I just registered on your site. I explain to you what led me there. My wife was diagnosed with ovarian cancer about 2 months ago. 11 cm tumor. She was due to have surgery on October 15, but after careful consideration, we have decided by mutual agreement to cancel or postpone this operation. Before, we wanted to try “a simple and non-toxic treatment” which has given excellent results elsewhere, an approach advocated by the French doctor and researcher Laurent Schwartz. There is a catch: a key molecule in Dr Schwartz’s protocol is Hydroxycitrate (from Garcinia Cambodia), an excellent but weight-loss remedy, and my wife has already lost enough weight with her cancer. We fear cachexia. So I am looking for an effective treatment that does not lead to weight loss. There is hydrazyne, but it is very restrictive (you must avoid anything that contains tyramine). There is also Cesium, that too, it is not easy. Lots of side effects and my wife is fragile. While exploring your excellent site, I discovered that creatine supports methylglyoxal (a molecule with great anti-cancer potential) and may stop the cycle of cachexia. They say that methylglyoxal is relatively easy to access, but I can hardly find a supplier who agrees to sell it to a private individual. Sigma sells this very little toxic product which “should be used for the benefit of suffering humanity” only to laboratories and universities, and at the other supplier of scbt.com, it is three times more expensive and n is offered for research purposes only. I haven’t read everything on your site about methylglyoxal. If I can’t get it, could you put me on the trail for other protocols that might meet our expectations. Thank you
Jacques
Dear Jacques,
I am sorry to hear bout the challenges related to your wife’s health.
Jacques, here is what I would do:
– because the tumor is very large, I would consider its removal as soon as possible
– I would build a strategy around the surgery, based on drugs and supplements, with the goal of reducing the chance of recurrence
– If the oncologist is suggesting the addition of other conventional therapies, I would strongly consider those since ovarian cancer is often responding well to the available therapies
– If the options suggested by the oncologist are not acceptable for your wife (such as chemo) there is also the option to perform low dose chemotherapy which comes with very little side effects and with good potential for response
– I would build around chemo (or low dose chemo) a strategy to increase the chance of response of those
Therefore, given the size of the tumor, and for ovarian cancer, I would strongly consider the conventional options supported by cocktail of drugs and supplements.
Only when those are not available or effective, I would consider moving to experimental therapies such as methylglyoxal.
HCA is a good one, but I would see that as a supportive element and a part of a more comprehensive approach.
I can of course help with answering questions that you may have on the cancer treatments avenue, but please strongly consider the above. I would really go for removing the tumor via surgery. After that, there is a lot that can be done to minimize the chance for recurrence.
I hope this helps.
Kind regards,
Daniel
Merci Daniel pour votre réponse rapide
N’est-il pas possible de réduire cette tumeur autrement que par la chirurgie, la chimio et la radio ? C’est ce que nous voulons vérifier avant d’envisager une chirurgie. Si c’est possible, nous le verrons bien, car ma femme Ginette aura des examens le 13 novembre. Et alors nous aviserons. Nous sommes peut-être vieux jeu, ma femme et moi, mais nous nous méfions des traitements conventionnels. Pour nous, si on peut vaincre le cancer sans chirurgie, sans chimio ni radio, c’est mieux. Certains ont pu le faire. Si c’est possible, pourquoi pas ? Je crois qu’un médicament qui a des effets toxiques n’est pas vraiment un médicament mais un poison. La personne survit peut-être mais elle est amoindrie. Ce n’est pas vraiment une guérison. Il y en a de vraies guérisons. On en voit. Nous privilégions des remèdes non-invasifs et non-toxiques. Après bien des recherches et bien des lectures (articles, études mais aussi témoignages), j’ai proposé à mon épouse un cocktail de suppléments: acide alpha-lipoïque, Garcinia cambodgia (remplacé par resvératrol), curcumine et tumérones de curcuma, quercétine, oméga 3 (surtout EPA), carnosine, vitamine C liposomale. Nous avons aussi d’autres produits en réserve. Ce régime-cocktail a été entrecoupé, il y a un mois, d’une cure intensive d’artémisinine (15 grammes en 2 jours), cure qui tient lieu de chimio naturelle (ciblant exclusivement les cellules cancéreuses) et que nous voulons renouveler, en y ajoutant du resvératrol, dans les jours qui viennent. Je pense, j’espère ne pas me tromper, que la tumeur aura régressée. Le 13, c’est pour bientôt. Croyez , cher Daniel, que nous ne prenons pas à la légère votre conseil. Nous n’excluons rien. Nous serions idiots de le faire. Je ne suis pas un expert, j’ai mes intuitions, mais j’écoute aussi des experts. Et je cherche à savoir ce qui marche vraiment. On se reparle.
Cordialement
Jacques
Thank you Daniel for your quick response
Isn’t it possible to reduce this tumor other than with surgery, chemo and X-ray? This is what we want to check before considering surgery. If we can, we’ll see that, because my wife Ginette will have exams on November 13th. And then we will advise. My wife and I may be old fashioned, but we are wary of conventional treatments. For us, if we can beat cancer without surgery, chemo or radio, it’s better. Some were able to do it. If it is possible, why not? I believe that a drug that has toxic effects is not really a drug but a poison. The person may survive, but he is lessened. It’s not really a cure. There are real healings of it. We see some. We favor non-invasive and non-toxic remedies. After a lot of research and a lot of reading (articles, studies but also testimonials), I offered my wife a cocktail of supplements: alpha-lipoic acid, Garcinia cambodgia (replaced by resveratrol), curcumin and turmeric tumerones, quercetin, omega 3 (especially EPA), carnosine, liposomal vitamin C. We also have other products in reserve. This cocktail diet was interrupted, a month ago, with an intensive cure of artemisinin (15 grams in 2 days), a cure which takes the place of natural chemo (exclusively targeting cancer cells) and which we want to renew, by adding resveratrol in the coming days. I think, I hope I am correct, that the tumor will have shrunk. The 13th is coming soon. Believe, dear Daniel, that we do not take your advice lightly. We are not excluding anything. We would be fools to do that. I am not an expert, I have my hunches, but I also listen to experts. And I’m trying to find out what really works. We talk again.
cordially
Jacques
Dear Jacques,
I believe that the human body has capabilities to heal beyond our imagination. However, most of us are not trained to do that. It is like trying to run a marathon without training. Drugs, supplements and interventions buy us time so that we can train and run the marathon. Even Chris from https://www.chrisbeatcancer.com/ did a surgery before starting his diet and supplements to keep cancer away without chemo. When tumors are large, they present higher risk of metastasis and it is more challenging dealing with them – this is why my first reaction would be to remove it. However, nobody knows what is best, and everyone has his own route to success. So you should do what you feel it’s best for you.
Indeed, artemisinin and artemisia annua are very relevant. This is why I wrote a post about it some years ago https://www.cancertreatmentsresearch.com/artemisia-annua-its-extract-artemisinin/ and this is why we also have it as a product at MCS Formulas https://www.mcsformulas.com/vitamins-supplements/artemisinin-artemisia-annua/
Just go through this website and you will find many more treatment ideas and if you like me to give you a feedback on the doses of the supplements you are using, you can send me the list of supplements and dose on the e-mail, and I will respond to that asap.
You mentioned that you are trying to find what really works. The best method in my view to identify value and filter out the noise is to search for options that have not only a story and anecdotes behind, but more important science and published case reports in peer reviewed journals with successfully treated humans.
Kind regards,
Daniel
Merci Beaucoup Daniel, je viens tout juste de prendre connaissance de votre message. Il est plein de sagesse, je n’ai pas le temps maintenant de vous répondre, mais j’aurai certainement des questions à propos des protocoles, des associations de produits qui peuvent agir en synergie, des posologies, etc. Je dois aller au travail, je vous reviens dès que possible.
Cordialement
Jacques
Bonjour Daniel,
Mon épouse a eu son examen de Taco ou TDM (Tomodensitométrie) le 13 novembre.
Une semaine plus tôt, elle a fait une cure de 3 jours d’artemisinine, soit 1er jour : 3 X 2gr art. + 3 X 600mg trans-resvérarol + 3 X 50 gouttes d’une teinture-mère d’artémisia annua (concentré de tous les principes actifs de la plante). 2e jour, même chose. 3e jour, même chose, sauf que la dose d’art. a été réduite de moitié, soit 3 X 1gr. Ce qui fait qu’elle a pris 15 gr. d’artémisinine en 3 jours (6+6+3). Nous comptons renouveler cette cure dans 3 semaines, mais nous aimerions avoir votre avis sur ce qui pourrait optimiser cette cure (suppléments qui peuvent y être associés et agir en synergie ainsi que dosages). Nous en tiendrons compte certainement.
Nous n’avons pas encore pu prendre connaissance de l’examen de TDM. Il a été envoyé au médecin de famille que Ginette devrait rencontrer le ou vers le 7 décembre. En attendant, voici une stratégie de traitement dont j’ai eue l’idée en cherchant sur votre site, et que j’ai proposée à mon épouse (l’idée de départ était, comme vous le suggérez quelque part, d’associer un inhibiteur de respiration à un inhibiteur de fermentation) :
(3 fois par jour à tous les 4-5 heures)
Un sachet de 3 gr de Vitamine C liposomale et un comprimée de 500 mg Vit. C orale + 500 mg Berberine + 1000 mg de L-Lysine + une cuillérée à soupe d’huile Oméga 3 (750 EPA, 500 DHA).
15 minutes avant ce traitement, ma femme prend une cuillérée à thé de Bicarbonate de sodium dans un verre d’eau. J’ai aussi acheté du jus de choucroute qui agit dans le même sens, je crois, qui est de réduire l’acide lactique, alcalaniser un peu le terrain. Devrais-je l’ajouter aussi ou le prendre à part ?
Je me demande ce que je pourrais ajouter pour bonifier ou optimiser ce traitement. Je pense à des suppléments comme EGCG, MSM, acide alpha-lipoïque, acetyl-l-carnitine, carnosine. Qu’en pensez-vous ?
Merci beaucoup encore, cher Daniel, d’être disponible pour des gens comme nous. Ici, au Québec, ces options de traitement n’existent pas. Quand on choisit un traitement naturel non-conventionnel, il est difficile d’avoir de l’aide. Le collège des médecins ne donne pas beaucoup de liberté de choix aux médecins. Nous le déplorons. Nous aurions aimé que des médecins puissent nous accompagner dans notre démarche. Ce n’est pas possible. Le médecin de famille de mon épouse n’a même pas voulu lui prescrire de la natrexone à faible dose, comme nous le demandions, article scientifique à l’appui. Cette femme-médecin n’osait pas s’aventurer. C’est dire.
Nous apprécions d’autant plus l’information que nous pouvons trouver sur votre site et de pouvoir compter sur votre aide désintéressée et vos conseils. Le Ciel vous bénisse !
Cordialement
Jacques
Dear Jacques,
You are a very kind person as I feel from your questions and comments. Because of that I would like to help you as much as I can. But I really think that you should not lose time. The tumor is large and needs to be removed in my view. Fighting a large tumor with supplements alone presents a large risk.
You mentioned you want to test various options before the beginning of December. However, any treatment may take several months until we can conclude if there is response or not.
On the other hand, if you are thinking about what to use to try to keep your wife safe until the surgery is done, I would focus on anti-inflammatory drugs and supplements. As anti-inflammatory, I would consider the following:
– Curcumin
– Olive Leaf Extract
– Black Cumin Oil
– Omega 3
– Ashwagandha
Cancers such as ovarian I would also address with statins (if not available, Citrus Bergamot may be relevant) and HCA. https://www.cancertreatmentsresearch.com/community/ovarian-cancer/drug-repositioning-of-mevalonate-pathway-inhibitors-as-antitumor-agents-for-ovarian-cancer/#post-793
Berberine could also be very relevant here. EGCG too. Regarding Fermentation inhibition, there are not many supplements available that can do a good job here.
In preparation for surgery, Vitamin D with Hydroxychloroquine may make sense. Here are some studies in breast cancer but it is expected to be relevant in other cancers https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3779365/ and https://cancerres.aacrjournals.org/content/77/13_Supplement/CT140
Kind regards,
Daniel
Bonjour Daniel,
merci du protocole que vous me suggérez pour assurer la sécurité de ma femme en attendant une éventuelle chirurgie. Je n’exclue pas cette possibilité (chirurgie), mais permettez que je vous explique ma réticence. Vous dites que le risque de métastases est plus élevé lorsque la tumeur est volumineuse. Vous avez peut-être raison, et je veux prendre en compte votre avis. Mais je ne suis pas convaincu que le risque de métastases est moindre avec la chirurgie. Je crois comprendre que les cellules cancéreuses se multiplient et s’agglomèrent pour former une tumeur. Cette tumeur est enfermée dans une sorte de poche. Quand cette poche est déchirée ou fissurée (biopsie, chirurgie), n’y a-t-il pas risque que les cellules partent dans le sang se fixer ailleurs pour former de nouvelles tumeurs qui pourront éclore 1-2 ans plus tard ? Ma femme et moi avons entendu bien des histoires de gens qui croyaient avoir réglé leurs problèmes avec la chirurgie. Leur cancer a resurgi, et ils ont dû subir de nouveau toute une panoplie de traitements très handicapants, cela sans véritable succès : nouvelle chirurgie, chimio, radio, …
Je ne veux pas trop m’étendre là-dessus. Disons que j’ai lu le livre de Ty Bollinger “Cancer, sortez de la boite”. Il ne donne pas toujours dans la nuance, c’est sûr, et je ne serais pas aussi radical dans mes jugements, mais tout ce qu’il dit à propos de ce qu’il appelle le “big 3” n’est pas dénué de sens. Quoi qu’il en soit, nous verrons bientôt si la tumeur a régressé. Et nous aviserons. Je vous tiens au courant.
J’entends suivre vos conseils à propos des suppléments que vous me suggérez. Mais j’aurais aimé quand même avoir votre avis sur la stratégie de traitement que j’ai proposé à ma femme, et qu’elle suit maintenant depuis 5-6 jours. Vitamine c liposomale à haute dose + Berbérine + L-Lysine + Oméga 3. J’ai fait mes recherches, et tous ces produits sont réputés très efficaces, mais je me demande si Berberine et L-Lysine vont bien ensemble. C’est toujours la question: Qu’est-ce qui peut être associé ou non ?
Dans un prochain message, je vous dresserai la liste de tous les produits, suppléments et nutriments dont j’ai fait provision pour combattre ce cancer. Peut-être pourrez-vous m’en conseiller qui correspondent davantage à nos attentes qui ne sont pas, je crois, irréalistes. Comme je vous l’ai dit, je privilégie les remèdes qui sont à la fois efficaces et non-toxiques, ou en tous cas à toxicité très faible. Aussi nous ne sommes pas très ouvert à la chimio. Pour mon épouse que j’aime, évidemment, j’espère le mieux, je me bats et j’espère une guérison, non une rémission longue, laborieuse et handicapante. Cher Daniel, je sais que vous avez perdu votre épouse, et que vous pouvez me comprendre. Croyez de mon côté à toute ma sympathie, notre sympathie. Merci de m’aider, de nous aider.
Cordialement
Jacques
Hello Daniel,
thank you for the protocol you suggest to me to ensure the safety of my wife while waiting for a possible surgery. I am not ruling out this possibility (surgery), but allow me to explain my reluctance. You say the risk of metastasis is higher when the tumor is large. You may be right, and I want to take your advice into account. But I am not convinced that the risk of metastasis is less with surgery. I understand that cancer cells multiply and cluster together to form a tumor. This tumor is locked in a kind of pocket. When this pocket is torn or cracked (biopsy, surgery), is there not a risk that the cells will go into the blood and settle elsewhere to form new tumors that can hatch 1-2 years later? My wife and I have heard many stories from people who thought they had solved their problems with surgery. Their cancer resurfaced, and they had to undergo again a whole panoply of very disabling treatments, without any real success: new surgery, chemo, radio, …
I don’t want to dwell on this too much. Let’s say I’ve read Ty Bollinger’s book “Cancer Get Out of the Box”. He’s not always nuanced, that’s for sure, and I wouldn’t be so radical in my judgments, but everything he says about what he calls the “big 3” is not without meaningless. Anyway, we’ll soon see if the tumor has shrunk. And we will advise. I’ll keep you informed.
I intend to take your advice on any supplements you suggest. But I still wish I had your opinion on the treatment strategy I suggested to my wife, and which she has been following for 5-6 days now. High Dose Liposomal Vitamin C + Berberine + L-Lysine + Omega 3. I’ve done my research, and all of these products are known to be very effective, but I’m wondering if Berberine and L-Lysine go together. It’s always the question: What can and cannot be associated?
In a future post, I will list all the products, supplements and nutrients I have stocked up to fight this cancer. Perhaps you can advise me of some that better correspond to our expectations which are not, I believe, unrealistic. As I told you, I prefer remedies that are both effective and non-toxic, or at least very low toxicity. So we are not very open to chemo. For my wife whom I love, of course, I hope for the best, I fight and I hope for a cure, not a long, laborious and crippling remission. Dear Daniel, I know that you have lost your wife, and that you can understand me. Believe on my side in all my sympathy, our sympathy. Please help me, help us.
cordially
Jacques
Dear Jacques,
Thank you for the explanation. In the end, nobody knows what is the best way for each of us and if you feel you are making the best choices for you than I respect and will not question that anymore.
Regarding your question on if I think the strategy of combining High Dose Liposomal Vitamin C + Berberine + L-Lysine + Omega 3 is suitable, I believe is on the right direction but if I would only use supplements and repurposed drugs to fight cancer, I would make sure to use high dose of them and multiple substances to address one mechanism. For example, to address fermentation I would try to select at least 3 fermentation inhibitors to use. Next to a specific strategy such as the one you are now considering, i would also add drugs and supplements that are likely to add value such as high dose Curcumin, EGCG, and Metformin.
Here you can read a little more about the concepts https://www.cancertreatmentsresearch.com/summary-of-this-website/ and here you can find a nice list of fermentation inhibitors that you may like to consider https://www.cancertreatmentsresearch.com/drugs-and-supplements-that-block-fermentation-and-help-fight-cancer/
If there are specific questions, please let me know.
Kind regards,
Daniel
Bonjour Daniel,
Plus je lis sur votre site, plus je réalise la complexité du problème, et cela me rend humble. J’ai quelques questions spécifiques. Elle concerne la cachexie.
Je n’étais pas sûre que ma femme était cachexique, car son poids, qui avait baissé beaucoup, semblait s’être stabilisé (autour de 47/48 Kg) depuis 3 mois. J’attribuais cette stabilisation aux stratégies de traitement que nous avions adoptés. Mais son état de santé ne semble pas s’améliorer.
J’ai lu l’article qui parle des divers symptômes de la cachexie et qui les relie à une seule cause, l’anoxie. Les points cliniques cardinaux de ce syndrome sont énumérés dans cet article. C’est , à peu de choses près, exactement ce que je peux constater chez mon épouse : Perte de poids (plus de 5% de perte par rapport au poids normal). Perte de masse musculaire. Perte de tissu adipeux. Réponse minimale ou inexistante aux stratégies de traitement et aux suppléments nutritionnels. Difficultés dans les activités quotidiennes de routine. Fatigue marquée ou asthénie. Perte d’appétit. Détérioration progressive. Anémie.
Bref, tout cela est plutôt déprimant et m’amène à reconsidérer ma stratégie, à me recentrer sur les inhibiteurs de la gluconéogenèse. À la fin d’un article sur la gluconéogenèse en 2017, vous disiez voir dans l’hydrazine un outil à fort potentiel, mais déploriez ses effets secondaires et souhaitiez trouver d’autres inhibiteurs de la gluconéogenèse. Que pourriez-vous me conseiller d’autre que l’hydrazine, aujourd’hui, pour venir à bout de cette cachexie ?
Que pensez-vous de la créatine ? Vous savez. C’est ce qui m’avait attiré, son effet anti-cachexie, dans le protocole de traitement qui l’associait au Méthylglyoxal. Pourrait-ce être efficace comme élément d’un autre protocole contre la cachexie ?
Plusieurs excellents produits contre le cancer ont ou semblent avoir les mêmes effets bénéfiques que le jeûne et la restriction calorique. C’est le cas par exemple de l’HCA. Je sais que c’est efficace. Associé à l’ALA. Il n’y a pas de doute dans mon esprit (Voir le traitement métabolique du Dr Laurent Schwartz et les témoignages sur le site https://guerir-du-cancer.fr/). Mais quand il y a cachexie, va-t-on prendre le risque de maigrir davantage ?… Tout un dilemme.
Merci de prendre le temps de nous répondre, cher Daniel. Portez-vous bien
Cordialement
Jacques
Hello Daniel,
The more I read about your site, the more I realize the complexity of the problem, and that makes me humble. I have a few specific questions. It concerns cachexia.
I was not sure that my wife was cachexic, because her weight, which had dropped a lot, seemed to have stabilized (around 47/48 kg) for 3 months. I attributed this stabilization to the treatment strategies we adopted. But his condition does not appear to be improving.
I read the article that talks about the various symptoms of cachexia and links them to one cause, anoxia. The cardinal clinical points of this syndrome are listed in this article. This is roughly exactly what I can see in my wife: Weight loss (more than 5% loss over normal weight). Loss of muscle mass. Loss of adipose tissue. Minimal or no response to treatment strategies and nutritional supplements. Difficulties in routine daily activities. Marked fatigue or asthenia. Loss of appetite. Progressive deterioration. Anemia.
Anyway, all of this is rather depressing and leads me to reconsider my strategy, to refocus on gluconeogenesis inhibitors. At the end of an article on gluconeogenesis in 2017, you said you saw hydrazine as a tool with great potential, but lamented its side effects and wanted to find other inhibitors of gluconeogenesis. What could you advise me other than hydrazine today to overcome this cachexia?
What do you think of creatine? You know. That’s what attracted me, its anti-cachexia effect, in the treatment protocol that combined it with Methylglyoxal. Could this be effective as part of another cachexia protocol?
Several great cancer products have or appear to have the same benefits as fasting and calorie restriction. This is the case for example with HCA. I know it works. Associated with ALA. There is no doubt in my mind (See Dr Laurent Schwartz’s metabolic treatment and testimonials on the site https://guerir-du-cancer.fr/). But when there is cachexia, are we going to take the risk of losing more weight?… Quite a dilemma.
Thank you for taking the time to answer us, dear Daniel. Do you well
cordially
Jacques
HI Jacques,
Cancer is indeed a complex issue. But that is complex just because we don’t understand it well enough. Once we will understand it, it will be so simple. The potential simplicity is highlighted by the fact that when we use the right drug, one drug alone as simple as Mbendazole could be highly effective. However, while searching for this simplicity, we need to go through the complexity of cancer, as long as we do not get stuck into the details. This is what I am trying to do and a little of that is reflected in the content I share on this website: zoom in to the complexity, zoom out, change the perspective, and start again.
I heave’t had the chance to look back into gluconeogenesis again, but Metformin and Berberine can be good tools as well on this line. One other I want to look into during the coming hours is Cyproheptadine that is relevant to cachexia.
Yes, Dr. Schwartz has nice ideas and is a good person – I met him sometime in 2014 at his house in Paris 🙂
Have a nice weekend!
Kind regards,
Daniel
Hello Daniel. Greetings from Raleigh, North Carolina, USA. 2 separate questions:
1. Is there a contraindication, antagonism or cancellation of effects when a drug or supplement that inhibits mitochondrial respiration such as Ivermectin or Doxycycline and a drug or supplement that increases mitochondrial respiration such as DCA ? This is important because I have my son on Ivermectin and desire to add DCA soon.
2. How much Ivermectin is recommended for anti-cancer and for how long. I have studied at least 15 science studies and articles but cannot find the answer.
Thanks, Dr. Robert Toler
Dear Dr. Robert Tolder,
Very nice to hear from you!
1. Combining a mitochondria inhibitor and DCA is expected to increase ROS inside cancer cells as discussed here for the case of Metformin and DCA combo https://www.cancertreatmentsresearch.com/modulating-the-yin-and-yang-energy-of-cells-to-fight-cancer-pro-oxidant-strategy/ Therefore, it should be a good combination.
2. There is nowhere a direct answer to this question. I will need to study this subject in depth to come up with an educated guess regarding what makes sense. I intend to do this but not sure how soon I will be able to find the time, while Ivermectin is on my priority list. However, I was reading some years ago about an intensive treatment schedule to address various health challenges used by Simon Yu, MD Internal Medicine. Here is that document https://www.autismone.org/sites/default/files/yu.pdf You could consider contacting Dr. Yu Please check this and try to contact dr. You and if there is no result from that, I will spend some time to research the subject.
Kind regards,
Daniel
Thank you Daniel;
I am aware of Dr. Yu. I have read his 2 books and watched 2- 1hour video presentations by him.
The most I can determine from all this is he Rxs Ivermectin up to 48 mg. but for only 30 days.
The long term is what concerns my son and I.
I had him on 12 mg. twice a day for about 5 weeks. Then reduced to one 12mg dose/day.
The half life is up to 56 days !!! Therefore I was concerned about accumulation.
Another factor in my decision was that only 10 mg. total/day for 5 days is recommended for COVID.
I have read these studies.
If that dose is strong enough to eliminate that virus ( along with Doxycycline ), 12 mg./day should be plenty long term for cancer.
It is only available at retail pharmacies here in US in 3mg. tablets. Another testament to its power. A compounding pharmacy makes it for me in the 12mg.tabs.
Dr. Yu is well aware of the anticancer effects of Ivermectin and understands the rational of its use for cancer even if a parasite is not detected or suspected.
I do plan to ask Dr. YU his opinion on dosage for long term.
Thanks, again Robert
Hi Shanti,
My last communication with you was in February 2021 when my PSA was 3.66 and still PSMA scan was showing nothing.
Now in July 2021 my PSA shot up to 8.75 just in 4 months. My doctor ordered another PSMA pet scan. Now finally my PSMA has picked up a spot. The conclusion of the report is :
PSMA AVID NODAL LESION SEEN AT THE LEVEL JUST PROXIMAL TOTHE BIFURCATION OF RIGHT COMMON ILIAC VEIN. IN VIEW OF RISING PSA THIS LESION IS HIGHLY SUSPICIOUS OF RESIDUAL/RECURRENT DISEASE IN COMPARISON TO THE LAST PSMA SCAN DATED 9-2-2021.
NO DEFINITE EVIDENCE OF ABNORMAL PSMA EXPRESSING DISEASE NOTED ELSEWHERE IN THE REGION OF BODY SURVEYED WITH REST OF THE SCAN FINDINGS DESCRIBED ABOVE.
SHANTI now I have a single spot near Bifurcation of Right common iliac vein. This vein is in lower abdomen as checked by me on Google search.
Now I met two doctors to take second opinion.
1. First doctor suggested as the spot is less than 1 centimetre , if they do radiation they might miss the spot
So he is suggesting hormones. But they uploaded my PSMA CD and reports in their system and a team of
Radiation Oncologists with review and discuss my case and let me know about radion option. This is the
biggest cancer hospital in Delhi Rajiv Gandhi cancer hospital.
2. Next I met yesterday Dr.Ashok Vaisya of Medanta hospital. He is considered top medical oncologist in Delhi and many people from USA have taken stem cell or Dentric cell therapy from him as I read on some other cancer forum. He gave 3 options to me to decide
A) Radiation
B) Hormone
C) Surgery
In case of surgery doctor said we will remove the tumour by surgery and make injection from the tumour removed or preserve it for future Stem cell therapy if needed.
Now the doctor gave three option but refused to recommend which one will be the best suited for me. He left it to us to make a decision in next few days.
This is real confusing for me. In your earlier post you had said that these days they do radiation once a spot if found in the PSMA. You had also given a link for this of video of Dr.Eugene Kwon recommending radiation.
In case of Surgery the advantage may be that I will have tumour sample for future Sten Cell therapy.
As you have so much of experience and have gone thru various treatments for your husband, can you please help me in deciding the best option for me. I will be looking forward to your reply as I have to decide in next week or so.
Thanks again for your concern and helping me decide in fighting this disease.
Best regards
Santosh
Hi Santosh,
The spot radiation or the surgery both sound like good options, but I am not sure which is better. I understand that in India they offer a prostate cancer vaccine called Apceden made from your own tumor tissue. This treatment is not available in the US, but there is a gentleman who has had it done on the prostate cancer forum I am on and he speaks highly of it: https://healthunlocked.com/advanced-prostate-cancer/posts/142757371/paper-published-about-my-vaccine-treatment. From my understanding, there is a Dr. Suman at Fortis who provides this therapy and a Dr. Kumar with APAC Biotech who can also provide expertise on the therapy.
My thought with the Lu-177 is that, even though the scan is only showing one lymph node, it is almost certain that the cancer is in other areas so coupling the localized treatment with systemic therapy is ideal. I personally like Lu-177, but you can also consider chemo or ADT. Alternatively, you can have the lymph node removed or radiated and see how much it drops your PSA before deciding on a systemic therapy.
I would strongly suggest posting your situation and questions on the Advanced Prostate Cancer forum here: https://healthunlocked.com/. There are members there who have much more expertise than I do and who have undergone Lu-177 and APCEDEN vaccine treatment in India.
Best,
Shanti
Hi Shanti,
Last 10 days I met many doctors and took their opinions. Two Urology oncology surgeons were not in favour of surgery . They said from their past experience the patients they have operated in past 5/6 years invariably get cancer back in 1 to 2 years.
They preference Radiation or Hormone therapy to surgery.. They themselves being surgeons said that.
Than I went to APAC also and discussed about APCEDEN treatment with Dr.Bandana who is colleague of Dr.Kumar. She was in favour of Dendritic Cell therapy for me. But I talked to many other doctors and they were not in favour of APCEDEN because of poor success rate of this therapy. They sited Examples of cases they knew where this therapy had failed.
I had an appointment with Dr.Suman of Fortis hospital also but after meeting DrBandana at APAC , she told me to take a decision than she will arrange a meeting with Dr.Suman as both Fortis and Medanta hospitals are in tie up with APAC for their APCEDEN treatments.
So finally I decided to go for Radiation which is starting today. It will be a 7 days course with high dose radiation.
I hope I get the desired results.
Many thanks for your advice from time to time.
Best regards
Santosh
Hi Santosh, I wish you the very best for a successful treatment. You have consulted with some of the top doctors in the field and that puts you in a good position to make the right decision. Keep us posted.
Warmly,
Shanti
Thanks Shanti for your good wishes. Hope end result is good for me.
They will do PSA test 6 weeks after Radiation ends, than we come to know of success of Radiation therapy.
Right now I am having a very positive mindset going thru all this. Also your post about treating oligometastatic prostate cancer by Dr. Eugene Kwon gives me lot of hope.
Thanks and best regards
Santosh
Hi Shanti,
I forgot to tell you that I also met Dr.Ishika Sen at Fortis Memorial Hospital where 2 of your friends had taken LU -177 treatment. Dr Sen told me that in case my PSMA shows a Single Spot than she will not do LU-177. But in case Multiple spots are seen in PSMA than she will do LU-177.
So I showed her my PSMA report two days back and she said my case doesn’t warrant LU-177 treatment.
She is a fine doctors and listens to you very patiently and gave us about 1 hour when I first went and met her and discussed in detail.
May be in future I may need her , you never know.
Regards
SANTOSH.
Hi Shanti,
Hope you and your husband are doing fine. It’s almost 9 months since I wrote to you last.
So in July 2021 PSMA Pet Scan showed one spot of 9mm near Right Common Illiac vein in pelvic area.
After taking few opinions I got it Radiated in last week of July.. my PSA came down marginally after 6th and 10th week of Radiation. But than it started rising again and went upto 9.3.
Another PSMA Pet scan revealed the tumour at same site plus an additional tumour next to it.
So it appears they failed to give proper radiation and it failed.
So I was searching for option and came across Apollo Proton Center in Chennai. This is the only Protone machine in India right now. So I contacted them .
They reviewed all my papers , PSMA pet Scans , Radiation discharge summary etc etc and came to conclusion that they will give radiation again ( not proton) to entire Pelvic area with emphasis on the location of disease. This way they will suggest they will be able to kill the tumour and also some micro cells in Pelvic area.
After getting the opinion from this Radiation Oncologist from Apollo proton centre I talked to my doctor . But he doesn’t agree with this idea and has put me on Hormone therapy namely Eligard.
Now the problem is that I discussed with 3 radiation oncologist about the advice of Apollo proton Center and they all agree and want to do it themselves.
But when I discussed with my doctor who is basically a Uro Onco Surgeon expert of Robotic surgery and who did my surgery in 2011, he doesn’t agree. Also I took opinion of another senior Medical Oncologist and he also doesn’t want me to go for Radiation. I showed him the video of Dr.Kwon on Oligometastatic, but still he wants me to continue with Hormones.
I am really confused. There was definitely a chance of curing me had they done proper radiation in July and killed the 9mm tumour. But my bad luck.
Can you share your thoughts and advice on what should I do. Right now my PSMA scan is showing disease in Pelvic area, ie. Right common Illiac vein region.
Looking forward to your reply.
Regards
Santosh
Hi Santosh,
I’m sorry to hear about the reoccurrence of the cancer. Since you have two detectable spots in the pelvic area (lymph nodes?), the assumption is that there are also micrometastasis that are not yet visible. For that reason, in my opinion, pelvic radiation with an extra focus on the visible mets is warranted. Studies have shown that radiation therapy to the prostate bed and/or pelvis works best when given along with ADT of at least 18 months duration. You can read some of the data here: https://www.prostatecancer.news/2022/01/optimal-duration-of-adjuvant-adt.html.
Perhaps your doctor thinks “the horse has already left the gate” and the cancer has spread beyond the pelvic region and that is why he is advocating for ADT alone and forgoing pelvic radiation? But if that were the case, standard of care in the US is ADT plus a secondary androgen disrupter like abiraterone or apalutamide.
I would highly encourage you to join the Health Unlocked Advanced Prostate cancer forum and post your case there. There are people on that forum who are far more knowledgeable than I am and you may get additional insights. A man who goes by the name of Tall Allen is particularly helpful and knowledgeable and writes the blog site I linked to above. https://healthunlocked.com/advanced-prostate-cancer.
Best regards,
Shanti