How Caffeine Makes Chemo- Radio- & Immunotherapy More Effective

Caffeine is so well know by all of us, and this is why I will not discuss anything about it’s background. Instead, I will jump directly to discuss the aspects I find the most relevant for the potential of caffeine in cancer treatments. However, before that, I would like to make the point that Caffeine
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Chronotherapy: Taking the Treatment at the Right Time Has Major Impact on the Outcome

Dear Friends, Chronotherapy (timing of drug delivery with the appropriate phase of the circadian rhythm to achieve optimal efficacy) is a subject I intended to write about since some years ago. But somehow I never found the time as I gave priority to other subjects. However, today I’ve got an alert on a new patent
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Glucose Absorption Inhibitors to Inhibit Tumor Growth

Background: I am writing this post in the context in which multiple readers and contributors to this website have shown interest in the potential of drugs and supplements that have the capability to inhibit glucose absorption in cancer cells. I am glad to see this interest as I also find this subject very relevant and would like to
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Maraviroc: An anti-HIV Drug that Reactivates the Immune System to Fight Cancer

Introduction: Recently, with the help of a reader of this website (Thank you, Jose!), I came across a very relevant article, Immunotherapy in metastatic colorectal cancer for the first time utilizes the innate immune system, published on the website of the German Cancer Consortium (DKTK). This article describes the results of a recent clinical trial running in Heidelberg, Germany using an
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Omega-3 Fatty Acids, Budwig Diet & their Antitumor Activity

Summary: This is a long post so here is a short summary: Omega-3 fatty acids have anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. Because Omega-3 fatty acids are pushing out of the cancer cells the glutathione much needed for the cancer cell survival, Omega-3 fatty acids can be also combined with chemo and with that increase or enable chemo
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High Dose Vitamin C & Cancer

Background: L-ascorbic acid (C6H8O6), known as Vitamin C, has a variety of functions in humans, some of which are not yet fully understood. It was discovered in 1930 by Albert Szent-Györgyi (Hungarian, half Romanian by descent), who as a result of this discovery received  Nobel Prize in Physiology or Medicine in 1937. Note, that Albert Szent-Györgyi is the same scientist
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Hyaluronic Acid Modulation: Preventing Recurrence or Supporting Other Therapies – Otherwise Better Not

Recently, I was reading this article Why cancer drugs can’t take the pressure, arguing that “A major reason why cancer drugs fail is that they cannot penetrate the high-pressure environment of solid tumors.” and that the reason for that is a “naturally occurring molecule called hyaluronic acid, primarily responsible for generating elevated gel-fluid pressures in tumors.”
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Curcumin: A Star in Cancer Treatment Field

Summary: When searching for some of the most effective anti cancer natural extracts accessible, low cost and non toxic, Curcumin will be one of the first we will come across. Curcumin is an extract from Tumernic a yellow-pigmented curry spice that is often used in Indian foods. Curcumin relevance in cancer was so intensively researched so that
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pH in Cancer & Tumor Acidification: A Top Treatment Strategy

Summary: pH and Cancer is an intensively discussed subject both in the alternative treatment arena and fortunately more and more in the scientific arena. In terms of treatments, when we speak about pH in cancer I am thinking of treatments involving e.g. the well known Sodium Bicarbonate, Cesium Chloride, Germanium, etc. I am also thinking of diets such
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Pyrvinium Pamoate: An Anti Worm Drug with Important Anti Cancer Potential

Summary: Pyrvinium Pamoate (PP) (a quinoline-derived cyanine dye) is an relatively non toxic anthelmintic drug, FDA-approved, sold over the counter in countries like Sweden, Norway, Denmark used to treat pinworms in humans and animals. During the recent years this compound has been shown to effectively inhibit various cancer cells types such as brain, colon/colorectal, breast, prostate, etc. and
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How to potentially enhance Chemotheraphy effectivness

It is well know that tumors often develop resistance to (chemo) therapies via various mechanisms. Some of the mechanisms are well understood today and there are various drugs or supplements that may have the ability to suppress some of these resistance mechanisms. Bellow, I tried to cover most of the known resistance mechanism and indicate
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Cancer addiction to Cyst(e)ine & Lowering Glutathione inside cancer cells

Recently, I came across this nice article (Ref) which is in turn based on a recent publication (Ref.) arguing that in some types of renal cancer cells, cystine deprivation “presents an attractive therapeutic opportunity that may bypass the apoptosis-evading mechanisms characteristic of drug-resistant tumor cells.” However, as we will see Cysteine is relevant not only in renal cancer but in most of
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