Glucose Absorption Inhibitors to Inhibit Tumor Growth

Background: I am writing this post in the context in which multiple readers and contributors to this website have shown interest in the potential of drugs and supplements that have the capability to inhibit glucose absorption in cancer cells. I am glad to see this interest as I also find this subject very relevant and would like to
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Dichloroacetate (DCA): Effective, Cheap & Accessible Drug to Fight Cancer

Background: First, I will start this post by wishing all the readers a Happy New Year full of health for you and your family, and a lot of success in everything you do! I also like to specifically thank to Ann who was the first visitor/friend this year to post a wish to all of us
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Bisphosphonates: Against Skeletal Lesions + Direct Anti-Tumor Action

Background: Many cancers either metastasize to the skeleton or grow primarily within the bone marrow, where this growth frequently leads to hypercalcemia, severe bone pain, skeletal destruction, and pathologic fractures. Indeed, the skeleton is the most common site of metastatic disease, and some of the patients with advanced cancer may develop skeletal lesions (Ref.). Bisphosphonates (BPs)
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Thalidomide: From Medical Disaster to Miraculous Cancer Treatment

Background: In 1957, Thalidomide was an over the counter drug used by pregnant women in West Germany, against morning sickness and nausea. Thalidomide, was hailed as a wonder drug that provided a safe, sound sleep. Unfortunately the complete spectrum of Thalidomide’s action were not well understood at that time, and shortly after the drug was brought to the
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The Immune System Fights Cancer as a Metabolic Disease

Background: Scientists at the University Hospital and the DKFZ in Heidelberg, Germany have discovered that a protein from immune cells paralyzes the energy supply in tumor cells. The German Society of Pathology has awarded them with the Novartis Prize. The scientists have recently published their findings in Nature Communications. (Ref.) Mechanism: Natural killer cells “patrol”
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Citric Acid Inhibits Fermentation and Kills Cancer in Humans

Background:  Citric acid exists in large amounts in a variety of fruits and vegetables, most notably citrus fruits and was first time isolated from lemon juice.  Its salt form, Citrate, is an intermediate in the citric acid cycle (also called TCA cycle, TriCarboxylic Acid cycle, Krebs cycle, Szent-Györgyi – Krebs cycle), a central metabolic pathway for animals, plants and
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High Dose Vitamin C & Cancer

Background: L-ascorbic acid (C6H8O6), known as Vitamin C, has a variety of functions in humans, some of which are not yet fully understood. It was discovered in 1930 by Albert Szent-Györgyi (Hungarian, half Romanian by descent), who as a result of this discovery received  Nobel Prize in Physiology or Medicine in 1937. Note, that Albert Szent-Györgyi is the same scientist
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Methylglyoxal: Large Response Rate in Very Advanced Stages

Introduction: Methylglyoxal, a molecule also produce by human body, it is one of the substances with an anti cancer potential that stands out. I am enthusiast about it because of the following facts: It has clear science behind supported by a large amount of academic research Its anti cancer potential has been already demonstrated in humans It
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Cholesterol & Cancer: Inhibit ACAT to Kill Aggressive Cancers

Summary: Cholesterol is a lipid molecule present in the membranes of all mammalian cells and is essential for their growth and viability. As an indispensable constituent of plasma membranes, cholesterol affects properties and functions of membrane proteins such as receptors, enzymes, or ion channels. Cells produce cholesterol or are able to draw it from extracellular sources via
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Propranolol: A “Heart Drug” that Stops Cancer Progression due to Stress

Background: Propranolol is a drug commonly used to treat high blood pressure, irregular heart rhythms, pheochromocytoma (tumor on a small gland near the kidneys), certain types of tremor, and hypertrophic subaortic stenosis (a heart muscle disease). It is also used to prevent angina (chest pain), migraine headaches, and to improve survival after a heart attack.
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Quercetin: even more anti-cancer potential than Curcumin?

How I learned about Quercetin’s potential: Sometime ago I had access to a number of chemosensitivity test results and performed some analysis on them. These chemosensitivity tests are performed by specialized laboratories and essentially consists in collecting blood from patients, capturing the circulating tumor cells and then exposing these tumor cells to various chemicals in
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Hippo Pathway: Regulating Organ Size & Cell Proliferation

Background and Mechanism: Interestingly, a few years ago it has been published in Nature magazine a study reporting that glucose, the main energy source used for energy generation in cells, regulates the Hippo pathway (specifically its downstream effector YAP)(Ref.). This is very interesting and ground breaking because with this research it has been indicated for the first time
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pH in Cancer & Tumor Acidification: A Top Treatment Strategy

Summary: pH and Cancer is an intensively discussed subject both in the alternative treatment arena and fortunately more and more in the scientific arena. In terms of treatments, when we speak about pH in cancer I am thinking of treatments involving e.g. the well known Sodium Bicarbonate, Cesium Chloride, Germanium, etc. I am also thinking of diets such
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A few words on Monocarboxylate transporters and their relevance in cancer

Here we have a new and very good article on MCTs: Monocarboxylate transporters in the brain and in cancer It explains the role of MCTs in normal and cancer cells and an important point is related to the fact that although MCT1 has the highest affinity to lactate all MCTs (from MCT1 to MCT4) can both
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Pyrvinium Pamoate: An Anti Worm Drug with Important Anti Cancer Potential

Summary: Pyrvinium Pamoate (PP) (a quinoline-derived cyanine dye) is an relatively non toxic anthelmintic drug, FDA-approved, sold over the counter in countries like Sweden, Norway, Denmark used to treat pinworms in humans and animals. During the recent years this compound has been shown to effectively inhibit various cancer cells types such as brain, colon/colorectal, breast, prostate, etc. and
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Cancer addiction to Cyst(e)ine & Lowering Glutathione inside cancer cells

Recently, I came across this nice article (Ref) which is in turn based on a recent publication (Ref.) arguing that in some types of renal cancer cells, cystine deprivation “presents an attractive therapeutic opportunity that may bypass the apoptosis-evading mechanisms characteristic of drug-resistant tumor cells.” However, as we will see Cysteine is relevant not only in renal cancer but in most of
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Another weak spot of cancer cells: ATP citrate lyase inhibition

ATP citrate lyase is an important enzyme for he fast dividing cancer cells ATP citrate lyase (ACL or ACLY) is an intracellular enzyme (located in cytosol) responsible for the conversion of citrate that comes out of the mitochondria,  to acetyl-CoA and oxaloacetate. ATP citrate lyase is primarily expressed in lipogenic tissues. Other vegetative tissues express little to
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When cancer is deprived of essential nutrients Acetate is the fuel

Glucose is one of the principal fuels when it comes to cancer cells. More recently it has become clear that other fuel sources, including glutamine, lipids, and protein also play an important role in cancer. However, I was not aware about the relevance of acetate as a fuel for cancer cells. Indeed, while acetate can
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Phlorizin & Phloretin: a powerfull glucose transport inhibitor

Summary  I know and like Phloretin since long time ago but today I came across a very interesting (old) patent that is based on Phlorizin (a derivative of Phloretin) as an anti cancer treatment. Based on the science behind, safety and case reports, I think this is very interesting and below I will share the information
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