Salinomycin: One of the best

Summary

Salinomycin is as an antimicrobial and anticoccidial antibiotic. In 2009, a groundbreaking result was published in the scientific journal Cell (Ref), showing that Salinomycin can be effective in killing the cancer stem cells (CSC), the cancer cell population that is responsible for chemo resistance and metastasis. Although the study was focused on breast cancer, Salinomycin will do the same in most epithelial cancers.

In my opinion, this is one of the most effective anti cancer substance I am aware of, that can trigger an intensive anticancer response. However, somehow, the intensive response doesn’t happen always and it is not clear why. It seems that Sal works best in epithelial cancers. Example of epithelial cancers are cancers of endocrine glands (e.g. adrenal, thyroid, pituitary), breast, ovarian, lung, etc. Cancers that develop in epithelial cells are called carcinomas (Carcinoma is the term used for a malignant epithelial tumor). About 80-90% of cancers are this type. (Ref.)

Besides is wide effectiveness in various types of cancers, another strong point of Salinomycin is that even if it will not kill the cancer cells, it is a potent inhibitor of the ABC transporter P-glycoprotein/MDR1 in different cancer cells. Ref1 Ref2 This means that Sal will turn cancers that are or have become insensitive to chemo therapies, into cancers that will be again sensitive to chemo.

Soon after its discovery, in 2009, it has been patented by a company founded by the scientists who discovered the anti cancer effects of Sal. The company is also supported by Harvard University and MTI. Its name is Verastem. In their product portfolio, Salinomycin goes under VS-507 name while being promoted as an Wnt Inhibitor. During 2018, a new patent has been published on Salinomycin for cancer treatment (Ref.)

Update 27.02.2016: My understanding of Salinomycin today, based on personal view and that of others:

1. Salinomycin seems to be most effective in epithelial cancers
2. Salinomycin seems to work well when combined with Chemo (such as Cisplatin, Gemcitabine, Erlotinib and at least a few others) and/or 3BP
3. The Chemo and or 3BP has to be applied first and than Salinomycin after
4. Following the above, Salinomycin may lead to response that will decay in the following days of application if there is no other Chemo applied –> the effect fades away (I would not call this resistance)
5. If Chemo or 3BP is applied again than there is response again
6. Salinomycin must be applied at a delay of several days from Chemo and or 3Bp for the most intense response. That means that if Salinomycin is applied just after (e.g. during the same day) there may be no or little response to that
7. Following the Salinomycin effectiveness, cancer cells will die via necrosis – so there may be a strong immune reaction during the following days – blood measurements will show strong increase in LDH and others (e.g. potassium) for a few days suggesting tumor lysis (TLS). TLS can be dangerous if too much cancer is killed at once so it needs to be manged carefully.

Note that the above are extremely valuable conclusions following my intensive search for answers on this topic and identifying patterns.

Strangely enough, it seems that Salinomycin is not anymore on the pipeline of Verastem???

Case reports

Salinomycin as a drug for targeting human cancer stem cells.
“Salinomycin was therapeutically applicated €œfirst-in-man€ in 2010, in the context of a pilote clinical trial with a small cohort of patients with metastatic breast, ovarian, and head and neck cancers. Intravenous administration of 0.20-0.25 mg/kg salinomycin every second day for three weeks resulted in partial regression of tumor metastasis and showed only minor acute and long-term side effects, but no severe acute and long-term side effects observed with conventional chemotherapeutic drugs.”
“As shown in Figure 3, systemic salinomycin therapy induced a marked regression of the subcutaneous thoracal metastases. A biopsy of the regressive subcutaneous thoracal metastases was obtained after 12 cycles of salinomycin therapy, and the specimen was investigated by molecular histopathology. As determined by TdT-mediated dUTP nick end labeling (TUNEL) histopathology, ~85% of the cells had undergone apoptosis. Moreover, the serum levels of the tumormarkers Ca 15-3 (cut off <31€‰U/mL) and CEA (cut off <3.4€‰ng/mL) declined from 14.3 U/mL and 50.8€‰ng/mL before salinomycin therapy to 7.2 U/mL and 15.5€‰ng/mL after salinomycin therapy, respectively. Intravenous salinomycin therapy resulted in minor acute side effects, including tachycardia and mild tremor for 30€“60€‰min. after administration but lacked severe and long-term side effects observed with conventional chemotherapeutic drugs, such as myelodepression, neutropenia, alopecia, nausea and vomiting, or gastrointestinal, thromboembolic, and neurological side effects. Similar results of salinomycin-induced partial tumor and metastasis regression were obtained in three other patients with metastatic breast cancer, one patient with metastatic ovarian cancer, and one patient with metastatic head and neck squamous cell carcinoma.” Ref.

Anecdotal reports/stories

Case 1: SCLC: Cancer Treatment Institute of Colombia Demonstrates Unprecedented Results Using Unique Cancer Drug Combination of 3-Bromopyruvate and Salinomycin for Treatment of Multiple Types of Cancer
With masses in both lungs and a depressed platelet count, the prognosis for the patient was poor; he had previously undergone standard chemoradiotherapy, but the cancer returned within three months. His attending physician recommended against additional treatments. At Cancer Treatment Institute of Colombia, the patient received 21 total rounds of salinomycin and 3-BrPA, delivered on alternating days. Chest CT scans four weeks later confirmed the total disappearance of SCLC. Just as encouraging was that the patient experienced no significant adverse reactions during his treatment.

Case 2: Adrenal cancer – to be added

I am sure there will be many to come.

Mechanism

Potassium ionophore, specifically targeting the cancer stem cells (CSC). As a result, it will induce an efflux of K+ from mitochondria and cytoplasm. While the CSC killing mechanism is not that clear to the scientists, here you can read a bit more about the possible mechanism.

One potential mechanism: Salinomycin treatment led to increased cytosolic Na+concentration, which consequently resulted in elevated cytosolic Ca2+ by means of Na(+)/Ca(2+) exchangers (NCXs) in the plasma membrane as well as the mitochondria. Elevated Ca(2+) then leads to calpain activation, which triggers caspase-dependent apoptosis involving caspases 12, 9 and 3. In addition, cytochrome c released from depolarized mitochondria directly activates caspase 9. (Combined inhibition of calpain and the mitochondrial NCXs resulted in significantly decreased cytotoxicity and was comparable to caspase 3 inhibition.) Ref.

Salinomycin induces activation of autophagy, mitophagy and affects mitochondrial polarity: differences between primary and cancer cells. Ref

Salinomycin, a polyether ionophore antibiotic isolated from Streptomyces albus, has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, and other CSC pathways. Ref

Salinomycin to selectively target €œCD133+€ cell subpopulations: http://link.springer.com/article/10.1245%2Fs10434-011-1561-2

Has been shown to kill CSCs in different types of human cancers, most likely by interfering with ABC drug transporters, the Wnt/β-catenin signaling pathway, and other CSC pathways http://www.ncbi.nlm.nih.gov/pubmed/23251084

The in vitro IC50 of salinomycin varies, depending on the source, cell type used and treatment period (Ref.).

Here is a new (2017) paper discussing various anti cancer mechanism of Salynomicin: http://journals.sagepub.com/doi/full/10.1177/1010428317695035  and below is a figure from the article, indicating the various mechanisms:

Update Sept 2017: A recent Nature Chemistry papers proposing a new mechanism related to Salinomycin’s anti cancer action: https://www.nature.com/nchem/journal/vaop/ncurrent/full/nchem.2778.html
This mechanism could sit at the basis of all the other mechanisms that have been previously identified.
In this paper it is suggested that Salinomycin is accumulating and sequestering iron in lysosomes. When the cells are left without Iron in cytosol, they will trigger the degradation of ferritin in lysosomes, leading to further iron loading in the lysosomes. Iron-mediated production of reactive oxygen species promoted lysosomal membrane permeabilization, activating a cell death pathway consistent with ferroptosis.
Here is a nice recent paper on Lysosomes as Oxidative Targets for Cancer Therapy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5516749/
To understand what Ferropoptosis is, you can read this paper: https://www.nature.com/cdd/journal/v23/n3/full/cdd2015158a.html

If indeed, this is the main mechanism responsible for Sal anti cancer mechanism, Iron Chelation prior to Sal treatments should be avoided. Indeed this paper suggest that Iron chelators can stop ferroptosis (Ref.). Opposite to that, Iron ionophores such as Disulfiram may help Salinomycin enhance this anti-cancer mechanism.

Interestingly, Chloroquine was suggested to work well with Salinomycin (Ref.) but due to a different reason. Based on the above, I can imagine Chloroquine can support the ferroptosis induced by Salinomycin due to a possibly similar action on Iron in the lysosames (Ref.)

Safety/Toxicity

This substance can be lethal if administrated at higher doses than it should. If on the other hand the administration dose is correct, as demonstrated by the articles above, there is a dose window where cancer cells are killed while the normal cells are not affected.

A case of accidental inhalation and swallowing of about 1mg/kg by a 35 years/old man leading to sever acute toxicity with acute nausea, photophobia, leg weekness, blod preasure elevation, chronic creatinine kinase elevation and muscle pain http://www.ncbi.nlm.nih.gov/pubmed/15107902
Note that this is about 4x higher dose than that used for cancer treatment.

Short term side effects have been reported and to my knowledge those may be: 30-60 min tremor after the administration, short term impact on peripheral view, fever after the administration, pain in the tumor area.

Inhibition of Na(+)/Ca(2+) exchangers (NCX) prevents salinomycin-induced neuropathy. Blocking mitochondrial Na(+)/Ca(2+) exchangers does not impair antineoplastic efficacy. Ref

Existing ion channel blockers, such as amiodarone, dronedarone, bepridil, aprindine, and cibenzoline, have been found to have an NCX inhibitory action. (Ref.)

Administration (Intra Venous – IV)

So far I am aware of two other administration protocols:

  1. Protocol as published in 2012 by the scientists from Heidelberg, Germany. This protocol has been administrated to multiple patients (4 cases published in one paper) with good results in all cases. The protocol used was suggesting the following:
    – one cycle is defined by 12 intravenous administrations, in alternative days (i.e. a total of 24 days)
    – each IV would consist of 0.200mg/kg to 0.250mg/kg Salinomycin (i.e. 10mg Salinomicyn in and IV for a person of 50kg receiving a 0.200mg/kg dose)
    – the cycles may be repeated after a few months
  2. A more intensive protocol I heard of being used:
    – one cycle is defined as 4 weeks treatment, 5 days/week (Monday to Friday)
    – each IV would consist of 0.250mg/kg to 0.300mg/kg Salinomycin
    – the cycle should be repeated 4x with one month break between each
  3. However, in other cases 0.180mg/kg to 0.200mg/kg is enough to trigger an immune response during the following 3-4 days, that includes episodes of fever and pain at the tumor site.

Substance used: Salinomycin >98%. This is relatively expensive and the total cost of material required for one cycle treatment is about 3500 euro.
Note that there is another version of Salinomycin i.e. Sodium Salt >90% which may be 10x cheaper. However its effectiveness in humans is unknown.
Also note that on the web we will find easy to buy 24% purity (which typically is Sodium Salt version). This is used for treatment of animals.

So, the best seems to be Salinomycin base version (CAS Number 53003-10-4) as it seems that this was used before in the published cases, but Salinomycin Sodium Salt (CAS Number 55721-31-8) may also be relevant.

Tumor acidosis enhances cytotoxic effects and autophagy inhibition by salinomycin on cancer cell lines and cancer stem cells. http://europepmc.org/abstract/med/27248168

Improving Sal effectiveness:

While there is a lot of research indicating that Salinomycin can overcome multi drug resistance, there is also research indicating that Salinomycin is a substrate of P-glycoprotein and P-glycoprotein over expression may also limit Salinomycin brain penetration as well as oral bio-availability (Ref.). Here is another example of research indicating that MDR1 overexpression leads to resistance to Salinomycin https://www.researchgate.net/publication/279529617_Drug_Transporter-Mediated_Protection_of_Cancer_Stem_Cells_From_Ionophore_Antibiotics

However, I do know based on genetic profiling of my wife’s tumor (but also specific literature) that she had a high MDR1 over expression level. And we did saw strong response to Salinomycin. So our results may also be related with some of the drugs and supplements she was taking, with MDR1 inhibition capabilities. Those are e.g. sometimes Verapamil, sometimes Ketokonazole. As a result, when there is no response to Salinomycin treatment, P-glycoprotein inhibitors such as Verapamil, Ketoconazole, or Tetrandrine should be administrated prior and/or during the Sal treatment.

Since MDR1 pump is ATP driven, lowering ATP prior to Sal treatment should also improve effectiveness. Using Metformin and/or Doxicycline would then help. Same applies for Phlorizin and 2DG. Note: we always used Metformin and sometimes Doxicycline. These will slow down mitochondria.

Preparation method:

I will share my research on this asap.

Source & Cost

Chemical suppliers such as Sigma. Salinomycin base version (CAS Number 53003-10-4). Material cost is a few thousands euro/dollars for one cycle (12 IVs) depending on your weight.

Synergies & Antagonsists

Synergies:

2-DG, 3BP, other glycolisis inhibitors: http://www.ncbi.nlm.nih.gov/pubmed/25912307
HDAC inhibitors (e.g. Valproic acid): http://www.ncbi.nlm.nih.gov/pubmed/24351423
Autophagy Inhibitors (e.g. Chloroquine): http://www.ncbi.nlm.nih.gov/pubmed/23670030
Doxorubicin: http://www.ncbi.nlm.nih.gov/pubmed/25892525
Metforminhttp://www.ncbi.nlm.nih.gov/pubmed/25375092
5-fluorouracil: http://www.ncbi.nlm.nih.gov/pubmed/24816638
Nelfinavir https://orca-mwe.cf.ac.uk/98987/1/Dunlop-Tee2017Oncotarget.pdf

Patents

Therapeutic compositions and related methods of use
Based on this the formulation was found to remain stable in normal saline up to 24 hours at room temperature.

Relevant Literature

Salinomycin suppresses TGF-β1-induced epithelial-to-mesenchymal transition in MCF-7 human breast cancer cells.

Acidosis enhances the ability of salinomycin to kill cancer cells and cancer stem cells

Preclinical drug metabolism and pharmacokinetics of Salinomycin, a potential candidate for targeting human cancer stem cells
Concomitant administration of Ketoconazole (KTC) on SAL pharmacokinetics: KTC, being a selective CYP3A4 inhibitor increased the systemic exposure of SAL significantly to 7-fold in AUC0-α and 3-fold increase in Cmax of SAL in rats with concomitant KTC administration.

Glucose starvation-mediated inhibition of salinomycin induced autophagy amplifies cancer cell specific cell death
Our in vitro studies further demonstrate that the combined use of 2-Fluoro 2-deoxy D-glucose, or 2-deoxy D-glucose with Salinomycin is lethal in cancer cells

HDAC inhibitors enhance the lethality of low dose salinomycin in parental and stem-like GBM cells.
Collectively our data demonstrate that the lethality of low nanomolar concentrations of salinomycin are enhanced by HDAC inhibitors in GBM cells and that increased death receptor signaling together with reduced mitochondrial function are causal in the combinatorial drug necro-apoptotic killing effect.

Salinomycin induces cell death with autophagy through activation of endoplasmic reticulum stress in human cancer cells. In conclusion, these findings provide evidence that combination treatment with salinomycin and pharmacological autophagy inhibitors will be an effective therapeutic strategy for eliminating cancer cells as well as cancer stem cells.

Salinomycin enhances doxorubicin-induced cytotoxicity in multidrug resistant MCF-7/MDR human breast cancer cells via decreased efflux of doxorubicin.

Salinomycin decreases doxorubicin resistance in hepatocellular carcinoma cells by inhibiting the β-catenin/TCF complex association via FOXO3a activation.

Salinomycin inhibits growth of pancreatic cancer and cancer cell migration by disruption of actin stress fiber integrity.

Salinomycin inhibits the tumor growth of glioma stem cells by selectively suppressing glioma-initiating cells.

Metformin and salinomycin as the best combination for the eradication of NSCLC monolayer cells and their alveospheres (cancer stem cells) irrespective of EGFR, KRAS, EML4/ALK and LKB1 status. In conclusion, METF in combination with SAL could be a promising treatment option for patients with advanced NSCLC irrespective of their EGFR, KRAS, EML4/ALK and LKB1 status.

Inhibition of autophagic flux by salinomycin results in anti-cancer effect in hepatocellular carcinoma cells.

Specific targeting of neurotoxic side effects and pharmacological profile of the novel cancer stem cell drug salinomycin in mice.  Inhibition of the mitochondrial Na(+)/Ca(2+) exchanger partially prevented the development ofsalinomycin-induced neuropathy in vivo, an approach which did not reduce salinomycin‘s antineoplastic efficacy in vitro.

Salinomycin treatment reduces metastatic tumor burden by hampering cancer cell migration. Our findings clearly show that salinomycin can strongly inhibit cancer cell migration independent of the induction of cell death. We furthermore demonstrate for the first time that salinomycin treatment reduces metastasis formation in vivo, strengthening its role as promising anti-cancer therapeutic.

Salinomycin increases chemosensitivity to the effects of doxorubicin in soft tissue sarcomas.

The cancer stem cell selective inhibitor salinomycin is a p-glycoprotein inhibitor. Treatment of the MDR cell lines with salinomycin restored a normal drug sensitivity of these cells.

Combining targeted drugs to overcome and prevent resistance of solid cancers with some stem-like cell features

Salinomycin and Other Ionophores as a New Class of Antimalarial Drugs with Transmission-Blocking Activity http://aac.asm.org/content/59/9/5135.full

Dual targeting of androgen receptor and mTORC1 by salinomycin in prostate cancerhttp://www.ncbi.nlm.nih.gov/pubmed/27557496

Androgen receptor (AR) and PI3K/AKT/mTORC1 are major survival signals that drive prostate cancer to a lethal disease. Reciprocal activation of these oncogenic pathways from negative cross talks contributes to low/limited success of pathway-selective inhibitors in curbing prostate cancer progression. We report that the antibiotic salinomycin, a cancer stem cell blocker, is a dual-acting AR and mTORC1 inhibitor, inhibiting PTEN-deficient castration-sensitive and castration-resistant prostate cancer in culture and xenograft tumors. AR expression, its transcriptional activity, and androgen biosynthesis regulating enzymes CYP17A1, HSD3β1 were reduced by sub-micro molar salinomycin. Estrogen receptor-α expression was unchanged. Loss of phosphorylated AR at serine-81, which is an index for nuclear AR activity, preceded total AR reduction. Rapamycin enhanced the AR protein level without altering phosphoAR-Ser81 and CYP17A1. Inactivation of mTORC1, evident from reduced phosphorylation of mTOR and downstream effectors, as well as AMPK activation led to robust autophagy induction. Apoptosis increased modestly, albeit significantly, by sub-micro molar salinomycin. Enhanced stimulatory TSC2 phosphorylation at Ser-1387 by AMPK, and reduced inhibitory TSC2 phosphorylation at Ser-939/Thr-1462 catalyzed by AKT augmented TSC2/TSC1 activity, which led to mTORC1 inhibition. AMPK-mediated raptor phosphorylation further reduced mTOR’s kinase function and mTORC1 activity. Our novel finding on dual inhibition of AR and mTORC1 suggests that salinomycin is potentially active as monotherapy against advanced prostate cancer.

Salinomycin: A new paradigm in cancer therapy http://journals.sagepub.com/doi/full/10.1177/1010428317695035

The primary hurdle in the treatment of cancer is acquisition of resistance by the tumor cells toward multiple drugs and selectively targeting the cancer stem cells. This problem was overcome by the chemotherapeutic property of recently discovered drug salinomycin. Exact mechanism of action of salinomycin is not yet known, but there are multiple pathways by which salinomycin inhibits tumor growth. Salinomycin decreases the expression of adenosine triphosphate–binding cassette transporter in multidrug resistance cells and interferes with Akt signaling pathway, Wnt/β-catenin, Hedgehog, and Notch pathways of cancer progression. Salinomycin selectively targets cancer stem cells. The potential of salinomycin to eliminate both cancer stem cells and therapy-resistant cancer cells may characterize the compound as a novel and an efficient chemotherapeutic drug.

Clinics Treating Patients with Salinomycin

Columbia: Advanced Medical Therapeutics 
My review: Unknown

US: Advanced Rejuvenation Institute
My review: Unknown

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learn on this road.

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Pavel
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Pavel

Dear Daniel,
I would like to ask should be there one month break after salinomycin cycle.
I combine salinomycin with Paw paw for treating my mother with metastasis. She has already the last phase of cancer and I am afraid to stop using salinomycin for one month because of cancer progress.

Please let me know soon,

Best Regards

Pavel

Emad
Member
Emad

Hello Daniel

where can I get Salinomycin Sodium Salt >90% ???

I cannot find it

and the other thing , is it okay for salinomycin to stay in warm condition for about 2 weeks ?

when I order anything from the internet it usually take about 2 weeks to arrive

Emad
Member
Emad

Daniel , is there any chance to take Salinomycin orally with a good results ?

is there any clinic giving it orally or any success reports about that ?

the same dose 0.2mg/kg orally , I’m wondering if the bioavailability is good or low ?

Emad
Member
Emad

because its hard for us to prepare IV’s , maybe I will be the first one you know who try Salinomycin orally

but also I will give it to my mother at the same dose as IV , 0.2mg/kg , and the purity is >90%

for me it’s better than nothing , I will try to get Salinomycin soon

Thank you so much 🙂

Tourniquet
Guest
Tourniquet

Hi,

just a heads up Salinomycin taken orally is highly toxic and can have life threatening effects.

Source: http://www.krebs-kompass.de/showthread.php?t=51961

danbodan
Member

This medication is inactive against fungi such as Candida. It is useless against Cancer as Candida is the main cause. You would be well advised to take mms or nitrile ideas. Far more beneficial.

Emad
Member
Emad

I didn’t notice your comments just until now

I will never use Sal Orally , but still concerned about the sodium salt version , it’s a lot cheaper but I will use it with my mother soon .

today I finally get the official email address of Tripoli university , it should be easy now to get anything I wan’t from the western chemical suppliers

I will get both Salinomycin versions , I will try the base version first , then I will try the other …

hope things work good 🙂

Emad
Member
Emad

Daniel , we contacted Santa Cruz scbt.com about shipping Salinomycin

due to many problems with airports here in Libya , they can’t ship in less than 5 days

it may took from 5 to 10 days , and they told us if the shipping time of Salinomycin took about 2 weeks , it may not arrive in a good shape

but they will try to ship in less than 1 week

however , we gonna use it anyway

and of course this means we cannot order 3-BP since it’s stability is very low , unless if my father travels to Germany the next month

———–

the other thing about Sal

isn’t there any information yet about the effectiveness of the Sodium Salt version ?

the chemical companies are talking about it’s effectiveness against cancer the same way they talk about the base version

but still I’m not feeling comfortable to use it , I wish I can know more about it

the base version is very expensive , we could only buy 2 IVs for my mother monthly , but also combined with MG

that’s what we have for now , and thank you so much 🙂

Paul
Guest
Paul

Hi,
Side effects of SAL maybe are manageable http://www.nature.com/cddis/journal/v2/n6/full/cddis201146a.html by inhibition of mitochondrial NCXs.Here is one such an inhibitor http://www.rxlist.com/vascor-drug.htm

Paul
Guest
Paul

Hi Daniel, it would be a real punch to cancer to increase SAL dose to the double, very cautiously and gradually of course. But who is so brave?

Emad
Member
Emad

I have just administrated Salinomycin to my mother now

she is feeling like tired, increased heart rate, blurred vision , fatigue , tired

Emad
Member
Emad

until now she is feeling heat

little tremor , but also she is feeling tired and fatigued , a little bit of pain in her arms

this is nearly half the dose , 0.1 to 0.12 mg/kg

Emad
Member
Emad

everything looks fine until now

hope it will continue like that 🙂

Emad
Member
Emad

Thank you so much Daniel

maybe I want to share some details about what happened

before 4 weeks , the tumor marker was 517, but because of low blood counts , the oncologist didn’t administrate chemo until 8 days later

in these 8 days , I give to my mother DCA only , but also because of delaying chemo , the markers may have been climbed a little bit

but I’m not sure about that , anyway

after that my mother received chemo and like always (combining chemo + DCA)

the last week I administrated Salinomycin to my mother (at night) , about half the normal dose (0.1 to 0.12 mg/kg)

and paclitaxel was enough to completely solubilize it !

immediately after administrating Sal , my mother felt like things are getting darker , and the heart rate increased (like she was running then became tired) , mild tremor , mild fever , some pain in her arms , felt weak a little bit

but also non of those side effects was annoying to her , she felt like things are going good , almost all the side effects disappeared after about 1 hour

some side effects didn’t disappear until about 6 hours , but the day after that she felt completely normal

yesterday (after about 4 days from administrating Sal) the tumor marker result was 408

it was a very good result , but I don’t know if I didn’t administrate Sal , what could the result be ?

I’m feeling like the cancer are trying hard to resist both DCA and chemo , I should use more than that to be in the safe side

but after all, I made it to this level , and I’m very happy about that 🙂

I have some questions related to Sal

what is the best time to use it ? the last day before administrating chemo ? or before that ?

I have only 15mg left (about 0.2mg/kg) so I need to use it carefully in the right time

also I will buy Salinomycin Sodium salt version , I need to try it and know more about it 🙂

sorry for my long comment and poor English language , and thank you so much Daniel for all your shared information

and from the bottom of my heart I wish the very best for both you and your wife

Steph
Guest
Steph

Hello Emad. Your experience is extremely valuable. Would you be kind enough to give details on how you administered SAL to your mother?

Was it through IV? How did you handle the preparation then?

Also, is it possible for an individual to buy products from a chemicals company? It seems it would require being a company or laboratory. How did you do it?

Thank you very much

Emad
Member
Emad

Hi Steph

first , thanks to Daniel for sharing all this information , I have just followed his words step by step

I’m not sure if I did it in a good way , but I will answer you about what I did

I give Sal to my mother through IV , I have a very clean glass vial , and put about 8mg of Sal powder in it (about 0.1mg/kg)

after that I added 0.5ml paclitaxel solution to the 8mg Sal powder , and without mixing it , just kept it 24 hours in the freezer , this was enough to solubilize Salinomycin

then I pull out the Salinomycin solution (Sal + paclitaxel) from the vial with a syringe

then put the sterile filter on the syringe to sterilize the solution , through the filter I pushed the solution into a 500ml NaCl , administrated during about 2 hours

and like I said I’m not sure if I done it in the right way but every thing went so good 🙂

————

regarding your last question , I got Sal from Santa Cruz , my father is a professor in the University of Tripoli (Libya) he have an official email address from the University

it doesn’t matter if you are a student or doctor or not in a university at all , all you need is an official email address from any university , if you don’t have it , look for your friends , its not hard to have one

and that is enough to let a chemical supplier sell there products to you 🙂

Kind regards

Steph
Guest
Steph

Hi Emad,

thank you so much for this info. You seem to have some experience in those things as it looks fairly difficult. Anyway, I’ll look into it. My wife has GBM and I’m trying to find additional treatments on top of chemo as chemo-resistance occurs in most cases.

Thanks again.

Emad
Member
Emad

It looks very difficult in the beginning , but it’s easier than you thought

there is one thing that you don’t know about it but its fairly easy to know about it , which is inserting the IV with cannula , and you can solve this problem by asking a friend or a nurse that can do this for you or help you learn about it

also it will be easier if you have a medical port , but don’t worry if you don’t know about it

if its not hard for you to insert IVs , then everything is solved !

anything else is easy to do , I can share much more details on how to prepare DCA and Sal , just make sure to know how to insert IVs with normal saline bags

the hardest thing you can face is the financial problems , which is the hardest problem for us now , we can’t make more than 500 euros per month

but in your case , having some help or experience isn’t hard at all

I will love to hear more from you , and will be happy to answer any questions here

my best wishes for you and your wife

Pouya
Member

Hi Emad, thanks for all the valuable info you shared. it’s a rather odd request and I know that you are busy with your own fight but is it possible for you to film yourself making Sal and DCA IV?
regards,
Pouya.

Emad
Member
Emad

Hi Pouya

OK its a good idea , its not an odd request

I will do it , I’m not sure if it will be in a good quality but I will show everything I can in it

but just you have to wait until Friday or Saturday

I will prepare DCA IV on Friday , and for Salinomycin I can’t prepare it until the next week

I will put it in my mind so its just a matter of time 🙂

I wish for you the best ,
Kind Regards

Steph
Guest
Steph

Hi Emad,

thanks a lot for your wishes. I was not aware of DCA and I find it interesting. You seem to administer through IV although I’ve read that it can be taken orally. Why IV? For Sal IV, it requires materials and tools first. I guess I need to ask a nurse about the whole process. It’s still something I’d rather let the doctors do, but unfortunately they would not want to hear about alternative approaches that are not fully validated. Too risky, maybe, but what is the risk of doing nothing but a standard protocol that is known to work very poorly in most cases?

Anyway, I’m looking forward to further news from you if you can give some, as your situation evolves.

Best wishes to you and your mother.

Emad
Member
Emad

Steph , Pouya

sorry for my late response

I was too busy and the internet connection is so bad these days here in Libya

I want to know how to share the video with you

and also with Daniel’s permission

I hope you all doing good

Pouya
Member

Hi Emad, thanks a lot for doing this,
this is my email address, [email protected] , also if you have either Whatsapp, Telegram, Viber, etc, let me know. it might be easier to send videos through them.

Emad
Member
Emad

My message has been sent to you

Emad
Member
Emad

Thanks a lot for your question Daniel
things didn’t go well recently
the chemo cycle has been delayed for 2 weeks because of low blood counts
then my grandfather (from my mother) passed away
and also the hospital just run out of most of the chemotherapy drugs
so after all they just give my mother Carboplatin , with no Gemzar (it used to be given in a combination)
and also , I have no Salinomycin left , just DCA with Carboplatin
today the results come out , the tumor marker climbed from 317 to 381
but thank god it didn’t climb more just like what happened several months ago
my next strategy now is to use Salinomycin monosodium Salt
https://www.scbt.com/scbt/product/salinomycin-monosodium-salt-55721-31-8
I contacted scbt.com , and they said that its purity is 90%
and still I don’t want to use MG , I want to keep it as my last option
again , thank you so much for your question , my best wishes to you all

Marina
Guest
Marina

Hello Daniel,

I am just wondering if you know if there are any clinical trials currently going on and testing salinomycin on cancer patients? I have not managed to find any…

Also, I am wondering if you have heard of Prof. Cord Naujokat and his work with salinomycin? He is apparently treating cancer patients with salinomycin, combined with immunotherapy or chemotherapy. We are considering it as a treatment, but it is impossible to find any results from these treatments. Apperently there are several doctors in Germany using Salinomycin, but I can´t find anything on how treated patients are now doing/what the success has been…. If you have any information on this could you please share it with us.

Kind regards,
Marina

Ergin
Guest
Ergin

Hi Daniel and Everybody,
I am very sorry about your wife Daniel.But we are very lucky that she has a brilliant husband like you.You made a valuable work for
all people.
I have been entering your website everyday and reading everything.I think there are hundreds of patients,sons,daughters
like me reading but not writing.I am researching for my lovely mother who has diagnosed with Ovarian ca spread to peritonium.
A very late stage as you know.I hope i am going to help people and we can make research alltogether.Now ca125 is 35.
We have used iv curcumin,iv vitaminC,hyperthermia and HBOT.We refused the surgery because she is 70 years old.And now we have to deal with cancer stem cells which is not gone by chemo.I can share my experiences if you need.
I have to say that EMAD is my idol.Extremely he makes a good care of his mother.
Tumor markers are going up and he makes them going down,amazing.I wonder the latest results of salinomycin treatment Emad.

Kind Regards,Ergin

Emad
Member
Emad

Thank you so much for your kind words Ergin
I hope from the bottom of my heart to see you win your own battle and save your mother , and hope the best for all the patients around the world , God bless them
I am too so sorry for what happened recently with Daniel , he was and still my hero
but for us, what we have to do is just keep fighting and do our best , we have nothing else to do
and to share about our recent results
the tumor marker declined from 408 to 317
what we did is like always : Chemo + DCA , (and also added one shot Salinomycin)
last week , I administrated Sal to my mother at night , about 0.2mg/kg
and after the administration she had a very strong tremor that last’s for over an hour , very strong tremor from her lips to her feet
I scarred a little bit, but it was only less than 2 hours , then everything became normal again
and there was other side effects like these which are mentioned in this post
and I should notice something , the strong effect added by Salinomycin are not showing on tumor marker ca 15-3
its only telling us that there is a good result , but how good is it are something I can’t know from this result
what I know is the side effects are telling me that there is a lot of cells died suddenly
if it was a normal cells then how could my mother feel completely normal after just a bit of hours !?
if its not an effect made by dying cancer cells then what is the origin of this strong tremor !?
I can’t track the complete effect , we can’t have a CT Scan right now , the tumor marker ca 15-3 are telling us whether there is a good result or bad , but usually we can’t know about how much cancer shrinked or progressed until we do CT Scan
until now , things are going good , but I can’t be happy until we can completely relay on treatments other than chemo , which is not easy for us with our financial problems , chemo are always doing damage to the immune system , and sometimes we are doing blood transfusion because of low blood counts
that’s all I have for now
my best wishes to you Ergin and for all the brave cancer fighters around the world

Ergin
Guest
Ergin

Hi Emad,
I cannot write anything.It says spam.I need your email adress.I may help you finding Salinomycin.
Ergin

anna
Member

I have also problems to post here.

Ergin
Guest
Ergin

Hi Daniel,

Although i am not a millionare,It is honour for me to help Emad if he accepts ofcourse.As we know that he has financial problems.I am going to buy Salinomycin from a seller which Emad choose.

I am always thinking like you.If the things goes upsidedown,what will i do ?ofcourse nobody wants to give advices in this website.
BUT Emad has a great story and i feel myself to help him.I hope his valuable work gives a positive feedback at the end.
Emad deserves some help.Am i wrong?
Kind Regards
Ergin

Emad
Member
Emad

Thank you so much Ergin for your willingness to help my mother
to me , this is enough to not forget your willing for help for my entire life
and i will always hope the best for your mother just as i hope the best for my mother
if you choose to help me , then i will choose the way that can help not only me , but also other people who are fighting cancer
I’m focusing on Salinomycin monosodium salt , its very cheep and if i succeed to have a good results with it
then other people will also use it easily as it will not cost thousands just like the base version
so at this point , i need to prove that the cheep version is working , it may save a lot of lives if it shows a successful results
https://www.scbt.com/scbt/product/salinomycin-monosodium-salt-55721-31-8
here you can find it , it only costs 146 dollars , that’s enough to help me and also enough to let all the people know whether its effective and probably safe or not
and again , thank you so much Ergin 🙂

Ergin
Guest
Ergin

Hi Daniel,
I have been searching for silver and salinomycin.And found this intresting article.
What do you think about silver nano particles.?
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4977082/
Kind Regards
Ergin

ergin inal
Guest
ergin inal

Hi Emad,
Could you please send your email adress.
I think Daniel has mine and can share with you.
Kind regards
Ergin

ergin inal
Guest
ergin inal

Hi Emad,
I am so sorry about your grandfather.
The dates and the messages are mixed so i didnt see that very bad happening.
For your mother,it seems dca doesnt work too much without chemo.But works a little bit as you said,the markers didnt get too much higher.
As i dont know if you use dca or not in 2 weeks.
I wonder your mothers blood counts aswell.
For my mother,the tumor markers begin to rise,but she was flu.I hope thats because of it.
This week we have pet scan.I want to write our story and treatments which we took;,after the pet scan results.
Kind regards
Ergin

Emad
Member
Emad

sorry for my late respond

I’m not happy to hear about the tumor markers are rising with your mother , but there is always some ups and downs with these markers , its not something we should afraid of , its always a matter of time to find the best thing that can work

as I said in the comment below , we all wish to hear a good news from you today Ergin

regarding your question , I was using DCA continuously and didn’t stop

Emad
Member
Emad

DCA IV , 60mg to 70mg every 2 or 3 times per week

ergin
Guest
ergin

Hi everybody,
You are all my hero, not only Daniel.
MEECH,PAUL,EMAD,ANN ETC..
You are all brave fighters,that who are genious and believe to science.
I have been going to all famous doctors in my country since 2015.But they have no knowlodge to answer my questions indeed.
They all said that my family is out of science because we refuse surgery.
Here i have found lots of answers to my questions.But also not enough.I think people have different psychology.This may be cause of the bad situation of the terminal cases.People choose alternative ways when they are in terminal case.(Although I dont want to say it is alternative,these are science)).
I also think twice when writing to this site.May be people think that this is a cure for themselves.But it is not.
I sent my mothers blood to USA for gene sequencing.There are lots of mutations there which does not belongs to ovarian ca.
I dont want to mix peoples thoughts,but they mixed mine by saying that chemo is poison.But i see that chemo works with those alternatives when you have to deal with cancer stem cells.
I have read 4000 academic papers in 12 months.And yes i found the answer.There is a cure for cancer.
It is HEAT with cytotoxic drugs and nano particles..But a huge conversation.We can not find brave enough people to search and done themselves.
I am an electronical engineer.We have been producing ecg monitors and electrosurgical devices since 1975.We have great technology both software and hardware..We produced mild hyperthermia devices for only muscles and physical therapies.But due to low demand we had to close the department.But now there is a big interest in magnetic nano particles thermal therapy.They cure mices %100 by salinomycin,silver,chemo,doxorubicin lipid,(cytotoxic drug) etc binding with magnetic nano particles,with chitosan etc and targeting them to tumors by antibodies or overexpression(Most famous CD44 or folate receptor) with HEAT.Also spinning particles cause necrosis without heat and a great responce of whole body immune responce by chitosan .Really interesing technology.My aim is first to try this tech on animals,especially dogs suffering from cancer.Later a clinical trial on human.
If we can see more people here we can really help others.
I never like to talk bigger than me.Tomorrow we have the results of pet scan.I hope it will be good.
I will write you our protocol if it will be good or not.
Kind Regards

Ergin

Emad
Member
Emad

Hi Ergin

thank you so much for your great words , I am sure your readings and searching will definitely give us the very good progress towards the cure for cancer

and we all are here to make this science reality

I hope to hear a good news from you today , god save your mother and all our lovers

Sincerely , Emad

ergin
Guest
ergin

Hi Emad,
Thank you for answering.I feel very lonely these days.It is very hard to find someone to help me and to help my projects.
Today i got the PET results.Totally dissapointing for me.There is no responce to treatment.All of the tumors are alive.
I think they became resistant.
But interestingly a little bit progress.3 months before and after no change as we got 9 chemos.I feel so tired tonight.
Tomorrow i will write our protocol.May be it helps someone who knows.

Emad please write me an email,where will i send the salinomycin?
Kind Regards
Ergin

Emad
Member
Emad

I’m so sorry to hear about that

the same feeling I had some months ago , when you thought you will see a good results then you see the opposite

but don’t let this feeling control you , there is a lot of alternatives that we never tried yet

did you try other strong alternatives like Sal , 3-BP , MG ???

if you didn’t try them , maybe its time to use them

what I mean is just focus on the next step , and I’m sure there would be treatments that will work for sure

please stay strong , I will send you my email

Kind Regards, Emad

ergin
Guest
ergin

Hi Friends,

Thank you very much for your kind words and want to help me Emad,Daniel.
You gave me a breath.Here is our treatment after diagnosis of ovarian ca,primary peritonium.
There was lots of metastasis on periton and there was an omental cake(the final word of cancer doctor said).
But only on periton and around the bowel neighbour to periton.
CA125 was 400 ,11 months ago.

1.)Three courses(3 months,9 chemo)taxane+carboplatin+nerium oleander injections.
CA125 was declined to only 5.WBC never went below 5.

2.)And we stopped chemo and refuse surgery.Only nerium oleander injecitons.
After 2 months past without chemo,CA125 begin to rise upto 95.

3.)We began chemo + iv vitamin C + iv Curcumin + local hyperthermia on abdomen for 2 courses(6 chemo)+metformin.
CA125 declined to 35.

4.)We had to change our doctor because he said we Must do surgery.

We began insulin potentiation therapy for 3 courses(9 chemo) with different doctor.
On chemo days iv mannose + iv sulphur + iv iron + iv vitc + iv vit b complex + hyperthermia + HBOT.
On normal days only pills(2DG + curcumin + melatonin + metformin + artemisinin + beta glucan)

There is no responce after changing the doctor.From first day to last CA125 rised to 57.
Still lots of tumors on peritonon PET last week.I am always thinking about iv curcumin.Is it our drug which works best?I began to use iv curcumin again.
2 weeks past now.WBC were always 2-2,5 range before iv curcumin.Now it is 3,6.
I wonder the results on tuesday(chemo day),especially CA125.

I talked with Dr,he said very surprising! and not good pet result.Now we have to make more agressive therapy.
He is going to use DCA on tuesday.He has Salinomycin and 3bp in his clinic but didnt try yet.
I really dont know what to do.The clinic is 450km far away from us.Everyweek we have to go by car.
There is stg wrong with his protocol i think.They all became resistant.He said he gives low dose chemo but wbc became very low
after courses.Ipt potantiates chemo.Last week her blood sugar downs to 30 during ipt.I was really afraid.
Normal blood sugar level is around 100 after we began to use 2DG and metformin.
Before it was around 175.

Daniel and friends.What do you think about our protocol?What is wrong with it?
Is it iron,sulphur,2DG etc.
Do you think that should we give chance to iv curcumin for one or two weeks before DCA?
Sorry for the quantities of the medicines.I will write them when i learnd the exact weights

Kind Regards
Ergin

Emad
Member
Emad

Dear all

today I tried Salinomycin monosodium salt today , about 0.12mg/kg

I didn’t notice any difference between the side effects of the base version or sodium salt version , its almost the same side effects

it was a low dose , my mother felt little tremor and increased heart rate , hotness , its almost the same side effects she felt when I give her low dose from the base version

that’s what I have until now

Ergin , thank you so much for everything , all my family thanks you so much for your great help , we will not forget it , and we always wish the best for your dear mother

also we cannot forget to thank you Daniel for sharing all this great information

I will continue to share everything in time

Kind Regards

ergin
Guest
ergin

Hi Emad,
I am happy that it arrived.Please be careful.
I hope it helps to your mother.Believe me i am living in internet and in Daniels website.
I always see you like my brother.We are a huge family here.I hope one day we meet eachother with our hero Daniel.

We began chemo today.Bevacizumab,gemzar,iv curcumin,iv vit c.
Tomorrow carboplatin.I hope it works.

After 2 days we interrupted DCA,collodial silver LDH COME TO 230! FROM 100.
Dr said stop DCA!!!
I asked for tinzaparin.He began laughing to me.He gave the lecture about tinzaparin today in class.
It makes nothing on tumor progress he said.On human,not lab.
I asked what about the resistivity releasing for platinium?
He laughed again.
I asked salinomycin.He never heard.
And so on.

Emad
Member
Emad

thank you again Ergin for your great help

sorry for being with that kind of a doctors , hope he just can give benefits with working strategies not just laughing

until now I didn’t share anything about these treatments to any doctor , they just can’t thing out of the box

but after you return to chemo again I think you will see better results in coming days

I really wish the best for you brother

Emad
Member
Emad

Hi Daniel

if we administrated Sal before 1 day from chemo or at the same day , would it boost the chemo effect ?

like inhibiting the ABC transporter ? if there is a high chance that it will boost the chemo effectiveness then we should consider it with chemo or before it, not just after it

ergin
Guest
ergin

Hi Emad,
May be your Dr has to change chemo.There should be another option.
Our dr changed carboplatin to oxaliplatin.And gemzar as you know.
But we met neuropathy for the first time.On hands and feet.

ergin
Guest
ergin

And he gives gemzar+oxaliplatin 2xmonth.
Avastin 1xmonth.
Are you using any antiangioegenesis inhibitor?

Emad
Member
Emad

Hi Ergin , the oncologist mentioned that if chemo Gemzar + Carboplatin didn’t go well , then she will change it

but for me I prefer to continue with (Gemzar + Carboplatin combination) there side effects are not so bad

my mother is always dealing with neuropathy , she is always taking B vitamins to help reduce the side effect

Emad
Member
Emad

Dear all

the tumor marker results today shows a very little decline from 334 to 322 !

like always , we used Chemo (Carboplatin and Gemzar) and DCA , also I have administrated Sal 3 times before chemo , and one other time after 1 week of chemo

and in all the times there was a marked tremor

the problem here is that blood counts are going down all the time , and with all this there is only little decline !?

I don’t know what to do ?

are there any mistake using DCA and Sal ? or maybe Salinomycin monosodium salt is not effective like the base version ?

or should I start using MG ? or should try Sal in the same day of chemo ?

I really don’t know what to do , very strange things are happening

Alex
Member

I wonder if this SAL can be made in a chemistry lab, DIY @ Home kinda thing.
Perhaps Emad would have some idea?
Thanks

Emad
Member
Emad

I don’t know

why don’t you buy it ?

is it financial problems ? or not able to have an email address of a university ? or you can’t administrate something like it ?

its not like I’m convincing you to give it , no , I can’t say to anyone to use it , its your responsibility , and when I use it , I took the responsibility by my self

but it feels comfortable to have some of these in your home , even just watching it without using it can make you feel better and more capable to stop the cancer

its just my thoughts

Alex
Member

All the above mentioned, yes.
THanks

Emad
Member
Emad

sorry to hear that

its frustrating indeed , but I’m mostly concerned about the financial problems

for me , 500 dollars monthly should be enough to access both 3-BP and Sal , and maybe you can even add what you used to add with your mother

the other 2 problems are used to be the biggest problems , but what I see is that they are so easy to solve , just having a plan to solve them will sure do the job

Alex
Member

Well, first of all i wouldn’t know where to give the 500 $ to get the treatments.
Second, i am not sure what other requirements are needed to be met to have the “pleasure” to pay that money for the treatments.
As for adminstering the treatments, i would get someone to do it, with a little help from you, thanks to your invaluable experience.
In the end we all want our mothers back in good health with a smile on their face. 🙂 So we best help each other as best we can.

Let us not forget the power of the mind.
https://www.youtube.com/watch?v=ztHa5h12ZsU
PS, if Morgan Freeman says it, it’s FACT! True Story Bro!
Now the fun side, https://www.youtube.com/watch?v=Maa0K4ycASo

Many Thanks,
Alex

Emad
Member
Emad

For the first and the second , Ergin know exactly everything about it

did you talk to him ? or you can ask him to give you my email so I can answer in details

regarding administration , I think the better thing is to ask Daniel about it , I’m sure he will help

and btw , I loved the both videos , especially the second one I watched it more than once 😀

wish you the best

Ergin
Guest
Ergin

Hi Emad,
Only the issue is an email ending with edu in Romania as you know.
The others is easy ,we talked with Alex.
we should talk it private.
Kind Regards
Ergin

manju
Member

Hi Daniel,

Many thanks for your monumental initiative.

This is a message regarding my mother’s breast cancer. She was diagnosed with ER-ve, PR-ve, Her2+ve breast cancer a year ago.During Feb-March this year she had integrative therapy in a Bangkok clinic which included various infusions, IPT and Hyperthermia, after which her tumor mass had reduced by around 70%. She was on supplements and vitamin c infusions during April and June. Since the markers were steadily moving, she tried Chlorine dioxide (MMS therapy) during the last three weeks after which the markers got elevated further. Together with ultrasound imaging, we are convinced that there is a progression of the disease again. We have not tried further chemo or Herceptin as yet since April 2017.

She is keen on trying Salinomycin (CAS Number 53003-10-4 ). We are hoping to get access although the dealer indicates that it is for research use only. If you think it is suitable, could you please let me know the dosage (she weighs 53 kgs) and procedure of making an IV out of it. Besides this, there is a rather ill-equippeed clinic which claims to sell 3BP in Bangalore. We are concerned about a lack of safe administration.

We have also thought of methylglyoxal (through Dr Manju Ray), but have deferred it fearing that she may not be able to use Metformin.

Her energy levels are not bad and she has been able to carry on with daily routine activities although her current appetite is around 70% of her usual intake. Her medical records can be accessed from the links in the PS below.

Any other advice would be also valuable. I would be happy to share any other information that you may require.

We had deferred Herceptin fearing its toxicity, but we are in a reconciliatory mood now.

Thanks,
Manju

manju
Member

Salinomycin IVs: My mother was diagnosed with ER-ve, PR-ve, Her2+ve breast cancer (no distant metastasis) in August 2016. During Feb-March this year she had integrative therapy in a Bangkok clinic which included various infusions, IPT and Hyperthermia, after which her tumor mass had reduced by around 70%. She was on supplements and vitamin c infusions during April and June. Since the markers were steadily moving upwards, and with ultrasound images indicating a small change in the tumour mass, she would like to try Salinomycin. Please educate on now Salinomycin IVs can be prepared. Thanks a million.

Jcancom
Member

Manju:

Was this the Brio clinic in Bangkok?
I noticed on their webpage that they offer 3-BP treatment.
If you went to the Brio clinic, was this treatment offered?

manju
Member

Jcancom: No, it is Verita Life. You may google! Interesting to know about 3BP at Brio.

Jcancom
Member

Manju:
I have suggested this formulation of MG to others. If you might have the ability to synthesize it, then it might
be of help.

Nanofabrication of methylglyoxal with chitosan biopolymer: a potential tool for enhancement of its anticancer effect

Ergin
Guest
Emad
Member
Emad

its interesting this ironomycin , hope these studies will be applied on humans soon

alternmed
Member

hi emad.

i have some questions,i ve read you were delaying the chemo/3bp/saly etc whenever your mom red blood were down.

1/the whit blood cells were at the maximum at that time right?
if the wbc are high that s mean there is immune activity (wich is probably cleaning and killing cancer cells)
2/what did you do to increase the red blood?
3/what are the risks if you do the perfusion when the rbc are down?

thanks in advance for your reply

Emad
Member
Emad

Hi alternmend , hope your mother is fine

1- no not at the maximum , but they were better than HB and Platelets , I am not sure why they are better but I didn’t notice anything special

2- at first we did give my mother a lot of supplements , natural and pharmaceutical , but at certain point the HB continues to drop after every chemo cycle , and then we decided to do blood transfusion which I believe it made cancer somehow more aggressive ! , DCA and chemo combination used to shrink the tumor , after doing blood transfusion it barely make it stable !!!

I’m not sure if its really because of blood transfusion but the real thing is that the resistance and aggressiveness started at the same time with doing transfusions

3- if you have a cancer patient that will do blood transfusion then maybe its better to do the transfusion at the end of the cycle , and do chemo after 2 days at least from the transfusion , also don’t do any transfusion after chemo at the beginning of the cycle , it may interrupt the chemo and make it weak , I remember when my mother did transfusion after 2 days of chemo , there was no effect at all , and the tumor markers jumped like a rocket from 322 to 650 in 1 month !

also if its possible to give anti-angiogenesis when doing transfusion it may help to not make cancer aggressive , in anyway the aggressiveness should happen temporarily , thanks to Ovidiu (our friend in this blog) he did talk about this thing

also to note , there are some chemo drugs like Gemzar and Carboplatin that cause the HB , RBCs and platelets to drop , but there are others which are more tolerable and will not cause the same problem

tell me if you have any other question , wish you the best

alternmed
Member

hi emad

thank you for your detailed reply

i have few more questions for you and members:

1/can we make a solution of sal with dmso? as i know it s not possible with sterile water or nacl

2/do you think it can be better if we inject it directly to the tumours (or nearby)

3/does you mother have swelling of the abdomen after the sal or the 3bp?

thanks in advance

Emad
Member
Emad

Hi alternmed

1- I didn’t try dmso but it may dissolve it at the beginning but then it will precipitate , I asked the same question to Daniel before

2- I really don’t have any idea about this one , but also Daniel may have

3- no, there is no observed side effects when using 3-BP , with Salinomycin the side effects are mainly tremor , and sometimes feeling things around becoming darker or brighter , increased heart rate and a little bit of tiredness (all are gone in less than 2 hours)

any other question please ask , i will be happy if my answers are helping

alternmed
Member

hi daniel

i have sent you the email on your website email address.

let me know

thanks

alternmed
Member

hi daniel

forwarded to the gmail adress

thanks

Ergin
Guest
Ergin

Salinomycin generate reactive oxygen species (ROS) .

Ergin
Guest
Ergin

A comparison study of the cytotoxicity of salinomycin and salinomycin sodium toward human breast cancer stem cells as well as breast cancer cells
http://en.cnki.com.cn/Article_en/CJFDTOTAL-XYGZ201104010.htm

Ergin
Guest
Ergin

I am not very sure that 3BP and salinomycin are synergetic.

Ergin
Guest
Ergin

Ofcourse i am not sure but if we look at their working mechanisms,i have question there.
Sal is working on ROS generation,3BP is working on OXPHOS inhibition partly if it is true ofcourse.
Sometimes ago i gave a link here,it says in glycolitic enviorement ROS works better.
When i find it i will give the link again.

visvitalis
Member

Hello, I read that 3-BP is used rectally (dissolved in water) in some clinics. However, I am interested if Sal or 3-BP can be formulated as suppositories instead? Would they irritate the bowel too much in the form of suppositories, what do you think?