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Luteolin ... effects on MDMX and where to buy?


toobs1234
(@toobs)
Joined: 2 years ago
Posts: 25
Topic starter  

I recently did some genetic testing and expression profiling of my tumor biopsy. One interesting result was that I have wild type P53, but overexpression of MDMX which disactivates P53. Luteolin is an MDMX antagonist via miR-34a at a dose of around 20mg/kg/day. However, I don't know of a good source to buy it in the EU. Does anyone have a source? Daniel, is this something for MCS or maybe a one-off supply for me?

 

thanks for any help on this


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toobs1234
(@toobs)
Joined: 2 years ago
Posts: 25
Topic starter  

There are chinese suppliers, but are they reliable? Anyone know about Vitamondo?

https://vitamondo.net/about-us/

but then getting it through customs ...


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Daniel
(@daniel)
Admin
Joined: 6 years ago
Posts: 1039
 

Hi @toobs 

Luteolin is an outstanding extract and we will have it at MCS Formulas at some point indeed, but is not yet planned as we are working on releasing other food supplements, so it will be next year, probably.

However, there are many western supplement companies providing this as capsules, so it should be easy to find it at known companies.

Kind regards,
Daniel


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johan
(@j)
Joined: 3 years ago
Posts: 585
 

Most Luteolin in food:Radicchio, Oregano(dried)

Synergies

Luteolin + EGCG
Enhanced Anti-tumor Activity by the Combination of the Natural Compounds ()-Epigallocatechin-3-gallate and Luteolin POTENTIAL ROLE OF p53*
https://www.jbc.org/article/S0021-9258(20)46997-2/pdf

Luteolin + Myo-inositol
Combined treatment with myo-inositol and luteolin selectively suppresses growth of human lung cancer A549 cells possibly by suppressing activation of PDK1 and Akt
https://www.researchgate.net/publication/339537471_Combined_treatment_with_myo-inositol_and_luteolin_selectively_suppresses_growth_of_human_lung_cancer_A549_cells_possibly_by_suppressing_activation_of_PDK1_and_Akt

Luteolin + celecoxib
Synergistic apoptotic effect of celecoxib and luteolin on breast cancer cells
https://www.researchgate.net/publication/233891877_Synergistic_apoptotic_effect_of_celecoxib_and_luteolin_on_breast_cancer_cells

Luteolin + Tamoxifen
Synergistic inhibition of drug resistant breast cancer cells growth by the combination of luteolin and tamoxifen involves Nrf2 downregulation
https://www.jocpr.com/abstract/synergistic-inhibition-of-drug-resistant-breast-cancer-cells-growth-by-the-combination-of-luteolin-and-tamoxifen-involve-6169.html


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