Making Cholesterol-Lowering Statin Drugs More Effective Against Cancer

Statins and Cancer Dear Friends, I am currently on holiday, travelling and with little access to the computer, but recently I came across interesting information related to the use of Statins to fight cancer, and would like to share that with you as soon as possible. So I decided to allocate a day and consolidate
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Case Report Stage IV Pancreatic Cancer: Good News from Jess

During this summer, on August 10, 2018, Jess was informing us (here) regarding the fact that her dad, dealing with Pancreatic Cancer Stage IV, will start a similar treatment approach as that successfully used by Marcos, and shortly discussed on this website (here). Jess and I have exchanged a large amount of e-mails this year and
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Case Report: Hepatocellular Carcinoma (HCC) Successfully Managed with TACE

Dear Friends, Below is a case report I recently received from Stefan, a visitor of this website. The case report is related to his sister-in-law, a 74-years lady, who has successfully managed a Hepatocellular Carcinoma (HCC) with a transarterial chemoembolization (TACE) performed at a hospital in Romania, Cluj. My purpose in sharing this with you
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Pancreatic cancer: Towards increasing treatment effectivness

Dear Visitors, below is a list of drugs recently shared with me by a reader of this website. It contains relevant information and consequently I decided to publish it as a specific article. I hope this will help: Currently the two most effective regimens in advanced pancreatic cancer are FOLFIRINOX (folinic acid, fluorouracil, irinotecan and oxaliplatin)
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Brain Cancer

Relevant drugs/supplements/protocols for brain cancer: cusp9 protocol (Ref.) Chlorimipramine, the keto diet and Boswellic Acid Noscapine inhibits tumor growth in TMZ-resistant gliomas http://www.ncbi.nlm.nih.gov/pubmed/21925789 Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas http://www.ncbi.nlm.nih.gov/pubmed/25542083 Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy http://www.ncbi.nlm.nih.gov/pubmed/25434381 Tetanus Vaccine Boosts Cancer Therapy http://www.nbcnews.com/health/cancer/tetanus-vaccine-boosts-cancer-therapy-n321596 Asparagine depletion potentiates
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Myeloma

Statin-Dipyridamole Statin-Dipyridamole combination for hematologic malignancies (and not only) New therapies are urgently needed for hematologic malignancies, especially in patients with relapsed acute myelogenous leukemia (AML) and multiple myeloma. We and others have previously shown that FDA-approved statins, which are used to control hypercholesterolemia and target the mevalonate pathway (MVA), can trigger tumor-selective apoptosis. Our
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Leukemia

I was shortly looking through potential solutions forLeukemia and here is a summary of my (limited) view on that so far: A major approach when trying to treat leukemia is to focus on Iron depletion (chelation). This can be done with Artemisin, Baicalein and Ciclopirox olamine or even Galium compounds. . Next to that, as
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Pancreatic Cancer

The list below will be continuously updated. Alpha-lipoic acid + low-dose naltrexone: Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases. http://www.ncbi.nlm.nih.gov/pubmed/20042414 Dipyridamole  Chloroquine see also my post on Chloroquine. Biological Approaches to Therapy of Pancreatic Cancer http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2882228/ A triple combination of atorvastatin, celecoxib
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Colon and Colorectal Cancer

Here are a few relevant elements. I will further improve the page when possible: Artesunate (Artemisinin): Cheap anti-malaria drug shows promise against colorectal cancer  Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells  In other words, Quercetin, Ibuprofen, Statins, Apigenin, etc. will help while Butyrate may not help in this specific case,
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ACC (Adrenocortical Cancer)

Update 22nd of August, 2020: Here is a report from 2017 showing again that Metformin (a cheap and available drug) is a potential solution for ACC – a young women using it with perfect results: Metformin and Melatonin in Adrenocortical Carcinoma: Morphoproteomics and Biomedical Analytics Provide Proof of Concept in a Case Study http://www.annclinlabsci.org/content/47/4/457.full Note:
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