When fighting with cancer I believe we need to take into account as many potential escape routes of cancer as possible and try to address most of those.  So here is what I would do:

First, we need to decide what is going to be the core of our anti cancer strategy. Anti oxidant or Pro oxidant. We do not have to be that strict about that but we always have to realize that some components may cancel each other before getting to the point in our body where they need to kill cancer. We will never know all of them how they really act at the cellular level but we would like to have some consideration regarding those that we know. For example using NAC supplement at the same time with Artemisinin may not be that clever since NAC is one of the most powerful antioxidants while Artemisinin will want to kill cancer via a pro-oxidant mechanism. So we do not want to use these two at the same time. Or another example that some cancer clinics are actually combining while I would not recommend is Glutathione with high dose Vitamin C. That is because Glutathione is an antioxidant while high dose Vitamin C is a pro oxidant at cellular level. Again, we can perform a short search on every of the items we want to add to the anti cancer cocktail of supplements and drugs just to make sure we do not add opposite extremes such as those mentioned above. If we find two that are acting against each other but still want to use them, we may want to at least administrate at some hours distance or maybe on alternative days.

I believe in the need to use a cocktail of supplements and (repurposed) drugs to be administrated two to three times every day. And I do believe that the diet has to be adapted as well. I may discuss my view on the diet in a separated post but now lets focus on what I would consider to add in the daily cocktail of supplements. So here it is:

  • Inhibiting metastasis:
    Cimetidine 400mg x 2/day with/after food (Source: eBay or Pharmacy) – Although it was never an issue in our case, note that Cimetidine may increase the plasma level of various drugs and supplements
    Natekinaze 2000 fu x2/day (Source)
    Modified Citrus Pectin** 5capsules/day (Source)
    Aspirin 100mg/day
  • Inhibiting fast cell division:
    Mebendazole €“ depending on the condition between 200mg and 1.5g/day administrated together with Cimetidine and with food (Source: eBay)
    Lovastatin 80mg/day (Source: pharmacy) Note: should not be administrated with 3BP
    Others that may be used here are Griseofulvin or Noscapine
  • Support the organs and immune system
    Vitamin D3 5000ui to 10.000 ui (Source)
    Pancreatic Enzymes 3x500mg 3x/day (Source)
    Bromelain Enzyme 1500mg/day (Source)
    Selenium  2x 200ui/day (not combined with Vit C) (Source)
    Super Omega 3 inc eha/dha 1000mg 3 x day (Source)
    Astragalus 500mg 2 x day (Source)
    Milk Thistle ( Silymarin ) 1000mg/day (Source)
    If possible since may be expensive: Propolis Bio30 3-4g/day (Source)
    R-Lipoic acid 900mg/day (Source)
    Probiotics
    Melatonin, 20mg/day
    Coriolus versicolor extract PSK/PSP, 3g/day
    Agaricus Blazei 3x400mg/day
    Reishi mushroom extract, 2.5g per day
    Cordyceps
    Black Cumin Oil 3g/day
    .
  • Killing cancer:
    This section has to be considered carefully since it should be the heavy weapon against cancer.
    What I would (almost) always use is: Honokiol HonoPure 3-4g/day, Metformin 1g/day, Curcumin 8g/day. Next to that I would consider series or parallel use of  some of the following Salinomycin, 3BP, Diflunisal, induced hypothyroidism, DCA, 2DG and so on. For that, we may want to have a look at the treatment strategies section on this site.
    .
    Natural extracts with serious anticancer action to consider (supplements or IV): Garcina HCA 3x500mg/day,  Graviola (600mg), Quercetin 5g/day (dont use with 3BP), Artemisinin 800mg/day, B17, Resveratrol, Sulforaphane , Lycopene, Genistein, Baicalein, Apigenin, Green tea Extract EGCG*, Germanium*
    .
    Note that, according to RGCC tests from multiple patients, the chance of the above elements in being effective against cancer cells is the following: Curcumin 94%, Quercetin 88%, Genistein 88%, B17 81%, Chloroquine 71% (an antimalaria drug), Vitamin C 69%, DCA 69%, Lycopene 63%, Honokiol 57%, Ouabain 57% (a cardiac glycoside), Artemisinin 56%, Baicalein 46%, Apigenin 43% More statistics can be found on the RGCC page.
    .
    And if is to consider both their chance to be effective and the average effectiveness here is the outcome: Quercetin 30%, Curcumin 22%, Genistein 19%, Ouabain 19%, Artemisinin 19%, B17 18%, Chloroquine 18%, Baicalein 16%, Vitamin C 15%, Apigenin 15%, DCA 13%, Honokiol 13%, Lycopene 11%. This statistics is made based on a number of 16 patients and while I think that every patient may want to perform such test (including the chemo list and the genetic profile), if that can not be done due to various reasons, the above numbers can always be used as a guide.
    .
    So what you can see from above is that all those components listed can kill cancer cells (in the lab) from many patients (there are others not listed that score much lower) and that Curcumin, Quercetin, Genistein are some of the most effective with a good chance to be relevant for many patients. The challenge with the natural elements from above is that most of them are not water soluble and as a result have a very poor bioavailability, usually <5%. This is why when administrated orally, the dose has to be high enough. A much better alternative is IV administration. Curcumin can indeed be found in IV form in Germany but so far that is not the case for Quercetin and Genistein.
    .
    What we should not conclude from the above statistics is that e.g. DCA is less effective compared to e.g. Quercetin only. Each has its own mechanism and using them in parallel may lead to synergies. Also what is not considered here is the pharmacokinetics which may be in favor of e.g. DCA when compared to a natural extract.

Many of the cancer killing elements above (and much more ) will be discussed in details in the section “By Mechanism” of this blog. But this list should help to get a bit of feeling on what I think is relevant.

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

184 thoughts on “Treatments

    1. its annoying when we see such promising approaches like this

      then without any comment it all fades !!!

      I hope to hear a real progress about delivering this thing to humans

      1. We’ve started erlotinib 150mg/day today.
        Other than that, things seem relatively stable so far.
        Still paralised
        I wonder if adding DCA would be a good idea since the tumor does involve the nervous system so much.
        I fear for permanent damage.
        Live is very hard sadly.
        I hope things are going better and better for you and everyone.
        My best wishes,
        Alex

          1. Dear Ovidiu,
            Do you have knowledge about oxaliplatin?
            For example mechanism of action,synergism with others etc.
            I wonder why they dont use it as a first line therapy for ovarian cancer?
            Does it work on only resistive cells?
            Kind Regards
            Ergin

            1. Sorry, don’t know much about oxaliplatin. Just that it’s better tolerated than other platinum drugs, probably because at the same dose, it’s better absorbed by cancer cells. This is due to cellular transporters, and care must be taken not to use other drugs (for instance celecoxib) that inhibit such transporters while taking oxaliplatin. It is also used in the treatment of ovarian cancer, but I don’t know why not as first line.

          2. Thank you very much Ovidiu.
            I hope you are doing well these days.
            I’m not sure if my mother has such a mutation, however the oncologist did ask for some tests to be performed on the extracted tissue, afterwards we had paperwork done for the drug.
            I sadly didn’t get to see the test results if any test was actually performed.
            We did however notice a massive drop in pain since starting the drug 3 days ago.
            I’ve made sure she gets some pro-biotics and enzimes, basic vitamins.
            My best wishes,
            Alex

            1. You better find out if your mother has the EGFR mutation or not. While I hope that erlotinib does work for your mother, my experience with it was bleak, during the 2 months that my father was on it (he didn’t have the EGFR mutation, but the drug was “free”) his CEA marker almost tripled. Only one week his CEA was stable, when he took 250 mg of disulfiram twice (but he complained about liver problems, so I didn’t dare to give it to him again).
              As I wrote some time ago, if the patient doesn’t have the EGFR mutation, it’s unlikely to work, and after about a month of erlotinib exposure there is an activation of STAT3 (which could be already activated for cells that did EMT). So it’s probable that after a month or two of erlotinib the cancer to become more metastatic. The possible solution is to add niclosamide, which is affordable.

        1. hello Alex,

          just copy pasting an interesting case of leptomengeal carcinoma after adenocarcinoma of the lung. Maybe could help?? why not show to the doctors. All the best.

          Case 1

          A 45-year-old female presented a headache which became more severe gradually in September 2006. In January 2007, the patient was diagnosed with NSCLC (adenocarcinoma) with brain and bone metastasis in our hospital. The patient showed frequent and severe headache, and even the omens of cerebral hernia raised. The CSF pressure reached 400 mmH2O. The level of tumor marker (carcinoembryonic antigen [CEA]) in CSF was abnormal with positive CSF cytology. We treated the patient with gefitinib (250 mg/day) therapy, but the symptom of headache did not improve. Two days later, the patient received intrathecal therapy (h-R3, 25 mg). After one intrathecal therapy, the clinical symptoms improved obviously. The frequency of the paroxysmal headaches was decreased from every 2 h to every 4 h after the treatment. Hence, continued intrathecal therapy (h-R3, 25 mg) was given at the 3rd day. One week later, the patient had slight headache occasionally. Then, the patient received intrathecal therapy (h-R3 50 mg) weekly. Two weeks later, the CSF pressure dropped to 120 mmH2O [Figure 1]. Then, the patient received the whole-brain radiotherapy. As showed by the result of brain magnetic resonance imaging [Figure 2], the LMC was improved after 1 month treatment. Then, the patient received intrathecal therapy (h-R3, 50 mg) combined with MTX weekly for three times. Three months later, the patient received intrathecal therapy for two times. The patient lived for 35 months after diagnosis with LMC and never had a headache during the lifetime after the intrathecal therapy.

  1. On 01.07, treatment with mebendazole, lovastatin, metformin and almost all the supplements discussed here began. On 15 .07 began to take CIMETIDY. About a few days later, they started abdominal pain, now they can not stand or go for more than 3 minutes. Has anyone ever seen such an effect? How can I solve the situation?

    1. Hello there.

      Mebendazole’s absoprtion is slower with Cimetidin. it means that the level of MBZ becomes VERY high if you take Cimetidine. it is causing the problems in my view. lower the dose of one of both asap.

    2. Hi !
      What was the dosage for Cimetidine?
      When I took 200mg Cimetidine, there were no side effects or other visible changes.
      Then 2 weeks later I switched to 800mg Cimetidine, I experienced abdominal pain and few episodes of subcutaneous bleeding (in visible places like my arms). As I could not see what is going on in other not visible parts of my body, I stopped Cimetidine.
      I was/am on other medications, so I think, Cimetidine just elevated the levels of some other medications in my body.

        1. Hi Daniel,
          I am on hormonal therapy for years. I used Cimetidine for short period of 2 or 3 weeks – around last radiotherapy and together with Letrozole (anti estrogen medication) and also other medications.
          Stopped cimetidine few weeks ago.
          They must be antagonists (antiestrogens and cimetidine)?
          i.

          1. Hi Ieva,

            Yes, exactly. That is why I asked. Cimetidine may interfere with some hormonal therapies and chemo due to inhibition of specific enzymes responsible for metabolization of those treatments. Same for grapefruit juice and other medications.
            In this case, using Cimetidine we gain on one hand (agains mets) and lose on the other as it may affect the effectivness of some therapies (e.g. tamoxifen). Cim is extremely valuable but the point is that before using it we need to check interactions with current treatments. Here I listed a link to an interaction checker https://www.cancertreatmentsresearch.com/links/

            Kind regards,
            Daniel

            1. Hi, Daniel !

              Thank You for Your response!

              I still do not see any relevant contraindications for Letrozole(anti hormonal – aromatase inhibitor) and Cimetidine. Could You, please, comment that? Should I be suspicious also about PPI Omeprazole and Letrozole?

              From this site
              https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2774495/
              “…Letrozole was a potent competitive inhibitor of CYP2A6 (Ki 4.6 ± 0.05 μM and 5.0 ± 2.4 μM in HLMs and CYP2A6, respectively) and a weak inhibitor of CYP2C19 (Ki 42.2 μM in HLMs and 33.3 μM in CYP2C19), while its metabolite showed moderate inhibition of CYP2C19 and CYP2B6. Letrozole or its metabolite had negligible effect on other CYPs…”

              From this site
              http://interactions.evidencewatch.com/
              “…PPIs (proton pump inhibitors) including omeprazole (Prilosec), lansoprazole (Prevacid), pantoprazole (Protonix), and esomeprazole (Nexium), and most H2RAs (histamine-2 receptor antagonists) including cimetidine (Tagamet), famotidine (Pepcid), and nizatidine (Axid) have CYP2C19-mediated hepatic metabolism and so represent potential adverse interaction with letrozole (Femara) which is also CYP2C19-dependent in part for its activity…”
              http://interactions.evidencewatch.com/

              From this site
              https://www.drugbank.ca/drugs/DB00501/biointeractions#enzyme-tab
              Showing BioInteractions for DB00501 (Cimetidine)
              they have common interactions with CYP3A4 , where Cimetidine works as “Substrate”. What does it mean “substrate” – does it induces or inhibit?

              Also this Cimetidine interaction page does not show anything about Letrozole
              https://www.drugbank.ca/drugs/DB00501#interactions

              Kind regards,
              i.

  2. Just want to update that I’ve agreed to be treated by Dr. Williams, in two or so weeks hopefully. He seems like a very knowledgeable, nice and experienced doctor, from our consultation. I’ll keep you guys updated as to how it goes and hopefully will be able to inform you on how the treatment feels/side effects/etc.

    I hope I can get back here with great results and have another quality resource for our members to explore.

  3. My favorite place to post a comment 🙂

    I hope everyone reading, will have a nice weekend, and good health, joy and happiness.
    I wish it to everyone!

    Brothers, sisters, heroes, care givers, patients.
    Thank you! – Best wishes,
    Alex

  4. Wishing everyone a nice a Christmas, may health return to those who need it. Last year this same day, i was browsing these pages looking for a cure for my mother. Desperate and sad. Still don’t think i found one, but we all have to stay strong so that another year may pass, one more day is another battle won, and maybe we can win the war.
    I’ve not forgotten anyone here. In my opinion, it’s good that the number of visits has decreased, this brings hope to me in thinking that maybe people are taking some time to be with their loved ones, the family, the friends.
    Let’s not forget to say how we feel to those who wait for it, while we still can.
    Thank you for everything.

    Merry Christmas – https://youtu.be/L2UCRNldC3s
    Don’t forget to smile

      1. Brother, i tried to call you on mobile but no answer.
        I am on skype like always.
        I hope you will find happiness again brother. I can only imagine it’s hard. Maybe harder than finding a cure for cancer.
        As for finding the cure this year, the more i looked into it the more i realize it’s next to impossible, especially for 2018. Maybe some day in the very distant future. Even then it’s going to be only for the extremely rich $$$
        https://www.youtube.com/watch?v=RyMoJHf7rCQ

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