FDA Places Clinical Holds on Opdivo and Keytruda for Refractory Multiple Myeloma

The recent news are related to combinations of Opdivo (nivolumab) and Keytruda (pembrolilzumab) tested in clinical trials for patients with refractory multiple myeloma. Here is discussed the specific trials that have been halted for: Opdivo (Ref.) Keytruda (Ref.) These drugs are some of the stars-drugs developed by some of the major pharmaceutical companies as part of
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Bisphosphonates: Against Skeletal Lesions + Direct Anti-Tumor Action

Background: Many cancers either metastasize to the skeleton or grow primarily within the bone marrow, where this growth frequently leads to hypercalcemia, severe bone pain, skeletal destruction, and pathologic fractures. Indeed, the skeleton is the most common site of metastatic disease, and some of the patients with advanced cancer may develop skeletal lesions (Ref.). Bisphosphonates (BPs)
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Thalidomide: From Medical Disaster to Miraculous Cancer Treatment

Background: In 1957, Thalidomide was an over the counter drug used by pregnant women in West Germany, against morning sickness and nausea. Thalidomide, was hailed as a wonder drug that provided a safe, sound sleep. Unfortunately the complete spectrum of Thalidomide’s action were not well understood at that time, and shortly after the drug was brought to the
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Dimethyl Fumarate: An Anti Psoriasis Drug Works Against Tumors

Background: A recent press release from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) discuss the results of German researchers who demonstrated that dimethyl fumarate (DMF), a drug used to treat Psoriasis patients can also help in the fight against cancer. This study has been performed on lymphomas and DMF appears to have at least comparable effectiveness and is better
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The Immune System Fights Cancer as a Metabolic Disease

Background: Scientists at the University Hospital and the DKFZ in Heidelberg, Germany have discovered that a protein from immune cells paralyzes the energy supply in tumor cells. The German Society of Pathology has awarded them with the Novartis Prize. The scientists have recently published their findings in Nature Communications. (Ref.) Mechanism: Natural killer cells “patrol”
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Maraviroc: An anti-HIV Drug that Reactivates the Immune System to Fight Cancer

Introduction: Recently, with the help of a reader of this website (Thank you, Jose!), I came across a very relevant article, Immunotherapy in metastatic colorectal cancer for the first time utilizes the innate immune system, published on the website of the German Cancer Consortium (DKTK). This article describes the results of a recent clinical trial running in Heidelberg, Germany using an
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Hyaluronic Acid Modulation: Preventing Recurrence or Supporting Other Therapies – Otherwise Better Not

Recently, I was reading this article Why cancer drugs can’t take the pressure, arguing that “A major reason why cancer drugs fail is that they cannot penetrate the high-pressure environment of solid tumors.” and that the reason for that is a “naturally occurring molecule called hyaluronic acid, primarily responsible for generating elevated gel-fluid pressures in tumors.”
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Glutamine Supplementation

Intro on Glutamine Glutamine is the most abundant, naturally occurring, non-essential amino acid in the human body. It is synthesized through enzymatic action of glutamine synthetase (GS) that combines glutamate and ammonia. It is synthesized through enzymatic action of glutamine synthetase (GS) that combines glutamate and ammonia. It serves as a vehicle for transporting ammonia in a nontoxic
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pH in Cancer & Tumor Acidification: A Top Treatment Strategy

Summary: pH and Cancer is an intensively discussed subject both in the alternative treatment arena and fortunately more and more in the scientific arena. In terms of treatments, when we speak about pH in cancer I am thinking of treatments involving e.g. the well known Sodium Bicarbonate, Cesium Chloride, Germanium, etc. I am also thinking of diets such
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Imiquimod: Potential treatment for Skin Metastasis

Summary  Safe, Effective and Accessible. Used originally on genital warts, it has proven beneficial in the treatment of basal cell carcinoma and can be useful in the treatment of skin metastasis such as those from malignant melanoma, breast cancer and others. Case reports  Imiquimod in the Treatment of Breast Cancer Skin Metastasis: We report a case of breast
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Gelum Drops: reducing lactic acid, increasing hemoglobin and lymphocytes

This is a German product that has been recommended to me by a German friend (Thank you!) and though I should share that with all the readers. So here it is her e-mail: “Just wanted to give you some information about a product, which you can share also with others (if you like). A natural
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Gut bacteria amplifies immunotherapy: the power of Probiotics

Today, I came across this very interesting news, adding support to a fast growing amount of knowledge suggesting a strong connection between gut bacteria and the immune system: Gut bacteria can dramatically amplify cancer immunotherapy “Introducing certain bacteria into the digestive tracts of mice with melanoma can help their immune systems attack tumor cells. The gains were
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ImmunoMax: a low cost immuno simulating vaccine

Summary A plant derived activator of natural killer cells (NK) at 2-3 hours after the injection. It is claimed that cytolytic capacity of NK cells is increased 3-fold after activation with Immunomax. Produced and registered in Russia for use as an antiviral pharmaceutical. It can be bought in small vials ready for injection and is administrated as an intramuscular injection.
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Anti PD-1 and anti PD-L1 Immunotherapies

Summary: A very new and promising immunotherapy approach to the treatment of cancer is the use of immune checkpoint inhibitors. These treatments work by “taking the brakes off” the immune system, so that the immune system becomes more effective in attack against cancer. Several different types of checkpoint inhibitors, targeting different checkpoints or “brakes” on immune
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Antihistamine to reverse immunosuppressive mechanism in cancer

Histamine is produced in the human body by some of the white blood cells called basophils, eosinophils, and by mast cells found especially numerous at sites of potential injury €” the nose, mouth, and feet, internal body surfaces, and blood vessels. Its role is to increase the permeability of the capillaries to white blood cells and some proteins, to
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Autoimmune disease & Quercetin

Autoimmune disease is aabnormal immune response of the body against substances and tissues normally present in the body. In other words the immune system starts attacking healthy parts of the body. I decided to shortly write about thisdisease since it is a potential side effect following treatments with immunotherapies such as DendriticCells or anti PD1/PDL1
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Plerixafor (Mozobil)

My opinion: Plerixafor works against the part of immune system (M2–macrophages) that helps the tumor to regrow after an effective treatment has succeeded to kill part of it. Therefore, Plerixafor is a great supportive treatment for any effective anti cancer strategy including surgery, chemo and radiotherapy. We do not have any experience with it. Summary & Mechanism The immune system plays a major
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