The Anti-Allergic Drug That Increases Appetite & Kills Tumors

The Anti-Allergic Drug That Increases Appetite & Kills Tumors

Author: Daniel S, PhD; Last update: January 31st, 2021 Introduction Dear Friends, With this post I would like to highlight a cheap and accessible drug that I think it is good to be aware of, given its anti-cancer potential. Its name is Cyproheptadine, it is FDA approved, and in most countries is sold over the
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Tumors Talk in a Language That Looks Like Viruses- Muting Them Could Prevent Progression & Metastasis

Tumors Talk in a Language That Looks Like Viruses- Muting Them Could Prevent Progression & Metastasis

Author: Daniel S, PhD; Last update: January 31st, 2021 Update Dear Friends, With this post, I am going to address a subject that may be key in oncology and that it is rarely discussed as it is related to a relatively new area of science. However, even if relatively new, it has already led to
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A Lower Cost Alternative to (anti PD1/PDL1) Immunotherapy?

Author: Daniel S, PhD; Last update: January 31st, 2021 Dear Friends, I just came across a recently published paper by scientists and MDs in oncology that deserves to be addressed in a post on this Blog. The scientific results come from MD Anderson Cancer Center & University of Alabama at Birmingham in USA, as well
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An Update and a Recent Finding Related to the Immune System Activity

Author: Daniel S, PhD; Last update: January 31st, 2021 Dear Friends, I will use this post to address two points: one related to the recently launched food supplement company MCS Formulas and the other related to a recent and relevant finding on modulating immune cell activation: Several points related to MCS Formulas and related activities
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A Method of Treating Triple Negative Breast Cancer

This is a short post to share with you a method for treating triple negative breast cancer, and potentially other cancers, involving: one or more checkpoint inhibitors in low dose hyperthermia treatment low dose chemotherapy lnterleukin-2 (IL-2) taurolidine [I discussed taurolidine in another post on this website (Ref.)] As you probably know, at this point
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How Caffeine Makes Chemo- Radio- & Immunotherapy More Effective

Caffeine is so well know by all of us, and this is why I will not discuss anything about it’s background. Instead, I will jump directly to discuss the aspects I find the most relevant for the potential of caffeine in cancer treatments. However, before that, I would like to make the point that Caffeine
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Chronotherapy: Taking the Treatment at the Right Time Has Major Impact on the Outcome

Dear Friends, Chronotherapy (timing of drug delivery with the appropriate phase of the circadian rhythm to achieve optimal efficacy) is a subject I intended to write about since some years ago. But somehow I never found the time as I gave priority to other subjects. However, today I’ve got an alert on a new patent
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Mistletoe: from Christmas Tradition to Cancer Fighting Tool

Background info: Mistletoe is a plant that grows as a parasite in various trees. It is well known as a Christmas decoration, under which lovers are kissing each other. There are various types of Mistletoe species but the name mistletoe typically refers to the Viscum album species. Mistletoe extracts are among the most widely used in
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FDA Places Clinical Holds on Opdivo and Keytruda for Refractory Multiple Myeloma

The recent news are related to combinations of Opdivo (nivolumab) and Keytruda (pembrolilzumab) tested in clinical trials for patients with refractory multiple myeloma. Here is discussed the specific trials that have been halted for: Opdivo (Ref.) Keytruda (Ref.) These drugs are some of the stars-drugs developed by some of the major pharmaceutical companies as part of
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Bisphosphonates: Against Skeletal Lesions + Direct Anti-Tumor Action

Background: Many cancers either metastasize to the skeleton or grow primarily within the bone marrow, where this growth frequently leads to hypercalcemia, severe bone pain, skeletal destruction, and pathologic fractures. Indeed, the skeleton is the most common site of metastatic disease, and some of the patients with advanced cancer may develop skeletal lesions (Ref.). Bisphosphonates (BPs)
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Thalidomide: From Medical Disaster to Miraculous Cancer Treatment

Background: In 1957, Thalidomide was an over the counter drug used by pregnant women in West Germany, against morning sickness and nausea. Thalidomide, was hailed as a wonder drug that provided a safe, sound sleep. Unfortunately the complete spectrum of Thalidomide’s action were not well understood at that time, and shortly after the drug was brought to the
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Dimethyl Fumarate: An Anti Psoriasis Drug Works Against Tumors

Background: A recent press release from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) discuss the results of German researchers who demonstrated that dimethyl fumarate (DMF), a drug used to treat Psoriasis patients can also help in the fight against cancer. This study has been performed on lymphomas and DMF appears to have at least comparable effectiveness and is better
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The Immune System Fights Cancer as a Metabolic Disease

Background: Scientists at the University Hospital and the DKFZ in Heidelberg, Germany have discovered that a protein from immune cells paralyzes the energy supply in tumor cells. The German Society of Pathology has awarded them with the Novartis Prize. The scientists have recently published their findings in Nature Communications. (Ref.) Mechanism: Natural killer cells “patrol”
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Maraviroc: An anti-HIV Drug that Reactivates the Immune System to Fight Cancer

Introduction: Recently, with the help of a reader of this website (Thank you, Jose!), I came across a very relevant article, Immunotherapy in metastatic colorectal cancer for the first time utilizes the innate immune system, published on the website of the German Cancer Consortium (DKTK). This article describes the results of a recent clinical trial running in Heidelberg, Germany using an
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Hyaluronic Acid Modulation: Preventing Recurrence or Supporting Other Therapies – Otherwise Better Not

Recently, I was reading this article Why cancer drugs can’t take the pressure, arguing that “A major reason why cancer drugs fail is that they cannot penetrate the high-pressure environment of solid tumors.” and that the reason for that is a “naturally occurring molecule called hyaluronic acid, primarily responsible for generating elevated gel-fluid pressures in tumors.”
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Glutamine Supplementation

Intro on Glutamine Glutamine is the most abundant, naturally occurring, non-essential amino acid in the human body. It is synthesized through enzymatic action of glutamine synthetase (GS) that combines glutamate and ammonia. It is synthesized through enzymatic action of glutamine synthetase (GS) that combines glutamate and ammonia. It serves as a vehicle for transporting ammonia in a nontoxic
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pH in Cancer & Tumor Acidification: A Top Treatment Strategy

Summary: pH and Cancer is an intensively discussed subject both in the alternative treatment arena and fortunately more and more in the scientific arena. In terms of treatments, when we speak about pH in cancer I am thinking of treatments involving e.g. the well known Sodium Bicarbonate, Cesium Chloride, Germanium, etc. I am also thinking of diets such
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Imiquimod: Potential treatment for Skin Metastasis

Summary  Safe, Effective and Accessible. Used originally on genital warts, it has proven beneficial in the treatment of basal cell carcinoma and can be useful in the treatment of skin metastasis such as those from malignant melanoma, breast cancer and others. Case reports  Imiquimod in the Treatment of Breast Cancer Skin Metastasis: We report a case of breast
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