• August 2017: approval of a patent on piperazine  to treat cancer leads to share price jump of a small biotech company (an anthelminthic especially useful in the treatment of partial intestinal obstruction caused by Ascaris worms)

“Rexahn Pharmaceuticals (RNN +27.3%) is up on almost double normal volume, albeit on turnover of only 577K shares, in apparent response to the issuance of a new patent (U.S. Patent No. 9,744,167) from the USPTO covering storage-stable nanoparticulate compositions and formulations of piperazine compounds used to treat and prevent proliferative diseases, including cancer.” (Ref.)

“Researchers have known that avoiding cross-resistance is key; this investigation tells us we also need to start considering drug holidays as well,” said Dr. Scott.

Fasting-like diet with chemotherapy strips away the guard that protects breast cancer and skin cancer cells from the immune system, according to a new USC-led study on mice. “T regulatory” cells which protect the cancer cells were expelled.

Inserted through the skin and into a vein, long-term intravascular devices such as IV catheters deliver to patients a range of life-saving medications, nutrition and fluids, among other uses. But these life-saving devices also can provide a furtive pipeline for germs from the external world to gain access to the bloodstream of patients who often already are sick, resulting in a serious infection or even death. Maki’s new approach for patients with intravascular catheters is a daily “rinse cycle” with a 25- to 50-percent solution of ethyl alcohol, or medical-grade ethanol. “We fill each lumen of the catheter with the ethanol solution and then cap it off,” says Maki. “It is allowed to sit there for an hour, rapidly killing any germs that have insidiously gained access. We then simply pull it back out and reattach the IV fluids, intraveneous nutrition or intravenous medications, and the risk of later bloodstream infection caused by germs that may have gained access in the preceding 24 hours has been essentially eliminated.”

The conclusion of this study: “We propose that ABZ induces oxidative stress promoting DNA fragmentation and triggering apoptosis and inducing cell death, making this drug a promising leader molecule for development of new antitumor drugs.”
I indeed know the potential of ABZ and like it for long time, and intend to once write a post on it. It is an over the counter and FDA approved drug – an anti worm medicine, easily accessible (e.g. eBay) and cheap.

According to this case report there is a risk when combining DCA with Artemisinin in intravenous forms.

PIK3CA mutations reprogram glutamine metabolism in colorectal cancer, Nature Communications(2016)  “In layman’s terms, we discovered that colon cancers with PIK3CA oncogenic mutations are addicted to glutamine, a particular nutrient for cancer cells. We also demonstrated that these cancers can be starved to death by depriving glutamine with drugs.”

This is a nice article published by The New York Times Magazine discussing Warburg’s discovery that was left out of textbooks altogether, and in this context cancer as a metabolic disease.

Patients receiving cancer treatment could increase their chance of survival by up to 20 percent and help stop their cancer from spreading by taking a low dose of aspirin, new research suggests.

This is compared to 80 to 90 percent achieved with previous techniques. In addition, “the current form of radiation is 44 treatments given over nine weeks. In contrast, the SBRT therapy we used allows the delivery of highly focused radiation in only five treatments, allowing patients to return to their normal lives more quickly”

Common cholesterol-lowering drugs could provide relief to patients suffering from a chronic lung disease, a study has shown. The drugs — known as statins — were found to help alleviate the chronic coughing associated with the disease for some patients. Statins are commonly prescribed for people at risk of heart attack because they can reduce cholesterol levels, but scientists are increasingly finding that they also have anti-inflammatory effects.

“The rate-limiting step in eradicating cancer today is not the science but the regulatory environment we work in,”

Researchers said those taking part in the trial were left astounded at the “mind-blowing” effect of combining two drugs – Herceptin, the current standard treatment for such cases, with a second drug called Tyverb.

Metastasis of breast cancer, especially to the brain, is the major cause of mortality. The inability of anticancer agents to cross the blood-brain-barrier represents a critical challenge for successful treatment. We demonstrate that penfluridol administration to an orthotopic model of breast cancer suppressed tumor growth by 49%. On the other hand, penfluridol treatment inhibited the growth of metastatic brain tumors introduced by intracardiac or intracranial injection of breast cancer cells by 90% and 72%, respectively. Penfluridol-treated tumors from all three models exhibited reduced integrin β4 and increased apoptosis. Moreover, chronic administration of penfluridol failed to elicit significant toxic or behavioral side effects in mice. Taken together, our results indicate that penfluridol effectively reduces the growth of primary TNBC tumors and especially metastatic growth in the brain by inhibiting integrin signaling, and prompt further preclinical investigation into repurposing penfluridol for the treatment of metastatic TNBC.

Controlling cancer rather than killing it could be the best way to fight the disease, according to scientists. I do like this concept indeed. I read a few years ago about it in an a scientific paper and I found the idea very good. The idea would be to use low dose effective treatments so that you do not kill all the cells sensitive to that treatment but enough to maintain a certain size. In this way the treatment responding cells will remain majority and will not give to the resistant cells the chance to take over and proliferate. Nice approach, at least in theory.

What causes cancer to grow and metastasize is not well understood by scientists. Now researchers have found a surprising link between the death of tumor-support cells and an increased risk of cancer metastasis in mice.

This study argues that killing cancer-associated fibroblasts (CAFs) may lead to metastasis. This is totally against the common believe that when trying to kill cancer we need to focus on killing the surrounding fibroblasts that support the growth of cancer. As a result, they suggest “time-controlled knockouts”.  To me, this makes sense but also makes things more complicated. In this case, I would make sure that when using a treatment option, I would use one that targets fibroblast and the tumor at the same time, such as 3BP or other metabolic treatments. At least don’t target the fibloblast unless using at the same time an effective therapy against the tumor.

Tumors kill off surrounding cells to make room to grow, according to new research. Although the study was carried out using fruit flies, its findings suggest that drugs to prevent, rather than encourage, cell death might be effective at fighting cancer — contrary to how many of the current chemotherapy drugs work.

This is an interesting concept and reminds me of a discussion around telomerase activators which can be seen as anti aging substances. Some suggested that telomerase activators should be avoided by cancer patients as they would increase the life not only of good cells but also of bad cells. However, if is to agree with the above concept, that we may actually see the telomerase activators not only as anti aging but also anti cancer elements. One of such element with (debated – Ref) telomerase activation capability is the well known Procaine which is also used as a treatment in German clinics and  first time discovered an applied as anti aging element in Romania by dr. Aslan. In the 1950s Dr. Ana Aslan of Bucharest, Romania performed experiments on lab animals injecting 2% Procaine and found that rats and rabbits live around 30% longer if given procaine injections. She wrote a book titled GH3 and became famous treating famous people. (Ref) The Procain product is called Gerovital and is available in Romanian pharmacies withouth prescription, in the form of pills or i.m. injections.

Tumor-associated eosinophilia is frequently observed in cancer. However, despite numerous studies of patients with cancer and mouse models of cancer, it has remained uncertain if eosinophils contribute to tumor immunity or are mere bystander cells. Here we report that activated eosinophils were essential for tumor rejection in the presence of tumor-specific CD8+ T cells. Tumor-homing eosinophils secreted chemoattractants that guided T cells into the tumor, which resulted in tumor eradication and survival. Activated eosinophils initiated substantial changes in the tumor microenvironment, including macrophage polarization and normalization of the tumor vasculature, which are known to promote tumor rejection. Thus, our study presents a new concept for eosinophils in cancer that may lead to novel therapeutic strategies.

Tamoxifen-treated neutrophils produced approximately three-fold more neutrophil extracellular traps (NETs), a mesh of DNA, antimicrobial peptides, enzymes and other proteins that neutrophils spew out to ensnare and kill pathogens.

Capsaicin binds to a cell’s surface and affects the membrane, which surrounds and protects the cell. At high doses causes the membranes to come apart.

The researchers identified a particular signaling pathway as the cause of this effect on the cells. “The PI3K/mTOR pathway is activated by the BMP7 protein and conveys signals for the cells to divide as well as to migrate,” explains team leader Pellegata. In order to verify this mechanism and to test potential future treatments, the team used two molecules. One molecule inhibits the signal transmission of BMP7; the other blocks the PI3K/mTOR downstream signaling pathway.

The toxicity of pharmacologic ascorbate is mediated by the generation of H2O2 via the oxidation of ascorbate. Our results demonstrate the potential clinical utility of pharmacologic ascorbate as a radiosensitizer in the treatment of pancreatic cancer.

Increasing Oxygen at the tumor site will increase the tumor susceptibility to natural killer (NK) cell€“mediated killing. Therefore, all the strategies focused on increseasing Oxygen in the body, such as Hydrogen Peroxide, Ozone therapy, etc. will increase the effectiveness of natural killer (NK) cell.

Clomipramine is an FDA-approved antidepressant drug.

A receptor on the surface of immune cells–the A2A adenosine receptor–is responsible for preventing T cells from invading tumors and for “putting to sleep” those killer cells that do manage to enter into the tumors. Now scientists shown that inhaling 40 to 60 percent oxygen (air offers 21 percent oxygen) weakened tumor-protecting signaling through the A2A adenosine receptor and awakened T cells that had gained the ability to invade lung tumors. And this can be further improved by the natural antagonist of the A2A adenosine receptor, which happens to be the caffeine in your coffee.

Scientists from the University of Sheffield found that when a therapy is effective in killing cancer, human body can trigger a process where white blood cells start clustering around blood vessels. These cells — called M2 macrophages — repair tissue damage and build new blood vessels, a process that sometimes helps the tumour to grow again after treatment. Using a drug available at pharmacies called Plerixafor (other names: Mozobil, AMD 3100, JM 3100, SDZ SID 791) can inhibit the repair tissue damage and build new blood vessels.

In my opinion, this is a great tool to add next to any effective anti-cancer treatment such as Salinomycin. The only challenge here seems to be the price which is about 7000 euro for a 24mg injection of Plerixafor. On the other hand, the same quantity of Plerixafor from pharma chem suppliers such as Sigma Aldrich costs a few hundred euros and it can be easily prepared as injection since it is water soluble.

Published paper: Perivascular M2 Macrophages Stimulate Tumor Relapse after Chemotherapy

23 thoughts on “News

  1. Hi D, what do you think of Oridonin? Perhaps combining it with autophagy inhibitors would be a good strategy to go with?
    sorry about the random post, thought this part of your website is the closest to a forum.

    1. Hi A,

      That is indeed true. We addressed this point often. Lactate represents a source of fuel for tumors in two majors ways:

      1. an indirect way, via gluconeogenesis where lactate is converted in glucose by the liver. This process can be inhibited with Hydrazine.

      2. a direct way, where lactate is absorbed by cancer cells via MCT1s transporters and converted in energy via respiration – therefore, for this process to work cancer cells need access to oxygen. These are also the cancer cells that will be most responsive to 3BP treatment.

      Kind regards,
      Daniel

  2. D, wanted to follow up on your March 11, 2016 news article.

    As hard as it is to believe, commentators have suggested that these responses resulted in no long term benefit to the patient.
    This does not seem reasonable to me, though read below url.

    “The statement was that the data don’t show that adding Tykerb does anything for patients, but rather show that continuing tamoxifen is useful. … responded that this is an accurate statement.”

    https://bcaction.org/herceptin-tykerb-meeting-with-genentech-and-heard-in-the-halls/

  3. D, that August 2016 article with the charged nanoparticles is so brilliant!
    I have been waiting for the next step in the research to go in vivo.

    The logic here is so strong!

    The export of lactate
    –> removes positive surface charges on cancer cells
    –> more negatively charged surface in cancer cells
    –> opportunity for positively charged nanoparticles

    Normal cells do not have negative charges on their surfaces.

    The nanoparticles are targeted to the cancer cells and then there is one could think of anti-cancer treatments.
    Perhaps something could be attached on the outside of the NPs.

    The instructions to make these NPs looks very very simple.

    1. Could anyone help out on how this could be converted to a more general treatment?

      The news report for the positive nanoparticles used a laser for a photothermal effect.
      What would obviously be of more relevance would be a charged nanoparticle that could
      be activated by electromagnetic or X-Ray treatment or would have some inherent
      treatment effect without other interventions.

      Is anyone aware of these depth penetrating electromagnetic or X-Ray approaches and how it might apply
      with this treatment?

  4. Just had a weird idea; What would happen if instead of producing lactic acid cancer cells produced ethanol?
    As we saw above ethanol is an anti-cancer therapy.

    What cancer cells could be made to produce their own chemotherapy?

      1. Helga,
        yes it appears that beer is the cure for cancer.
        I have no idea how this works.

        It is very difficult to believe, though it seems to have been used as a remedy in developing nations for quite some time.
        The application is limited, though, to more an intratumoral treatment.
        The new research found a way to keep the alcohol as a gel and this helped it to be even more effective.

        https://www.cancertreatmentsresearch.com/community/repurposed-drugs-and-new-substances/beer-cures-cancer/#post-213

  5. D, it is absolutely amazing!
    There is this wave of powerful anti-cancer treatments approaching from all sides!
    It feels very close now.

    Look at this one.
    They give all the chemistry of how to make it.
    The only cells that use this enzyme are sperm cells and cancer cells.

    They shut down this pathway in mitochondria and then glycolysis is pushed up.
    Amazing! Metabolism is right at the center of cancer,
    https://www.sciencedaily.com/releases/2017/10/171017124347.htm

      1. Thank you for your reply W!

        I am just so excited about what is happening right now.
        As you might know I have been very interested in 3-BP for quite some time.
        Yet, I am now starting to shift to these newer metabolic approaches.

        It really is amazing!
        For example, mitochondrial transfer PMID: 28342934
        or tocotrienol vesicles PMID: 28972460
        also mentioned the HK2 targetted peptide.

        This one is also big. If you can start introducing new miRNA or siRNA, how will cancer evade this?
        When Engenic knocked down with siRNA and then treated with minicells in mice the anti-cancer effect
        was essentially curative.
        https://www.prnewswire.com/news-releases/engeneic-announces-publication-in-the-lancet-oncology-of-first-clinical-study-employing-edv-nanocell-platform-to-enable-microrna-replacement-therapy-300513513.html

        It is simply endless!
        We are moving to a time when there will be a very large range of choices of non-toxic anti-cancer treatments.
        I sincerely wish that those people who need treatment options will be able to benefit from this research.

        I will love to hear what D might say about how these approaches could all be put together for a truly massive anti-cancer effect.
        For example, the E260 I noted above amps up glycolysis and depletes ATP. Perhaps an anti-glycolytic? Would also like to see what would happen if you then blocked up MCT-1.

        1. hey Alex,

          i was following you and all the folks here but indeed haven’t written for a while.

          You made my day by writing things improved a little bit for your dear mother. Is she receiving chemo now?

          as to my situation: my last checkup was ALL clear (i am 11 months after the end of chemo). I take only basic supplements now. Seemingly I am likely to have a mild paraneoplastic process or CFS /ME which is an underdiagnosed syndrome following trauma, infection, major drug intake (like chemo) or a combination of these. I had all these.

          I am glad the symptoms (back pain, mild neuro issues ) are probably not caused by cancer. the scenario i feared (lept mets) is getting very unlikely. You know whats funny? I always wrote that DCA helped me beyond any placebo effect and
          I am 100% sure it was not psychosomatic as first I did not believe in DCA. According to studies DCA is not just helpful but also against CFS / ME… Who knows by now.

          So all in all I am fine now, bro, same symptoms but no worsening and I am in good shape in terms of physical condition.
          Of course the thought of having recurrent / active cancer does not leave for a f*cking minute, especially with the complaints i have.

          thanks for asking, brother.

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