The Magic of Ivermectin in Oncology

Author: Daniel S, PhD; Last update: May 23rd, 2022

Dear Friends,

Some of you were used with me publishing a post nearly every month. However, during the past year that did not happen. The reason for that is that while I continue to be involved in the oncology space as much as I can, my activity in the supplement company MCS Formulas takes a large part of my time.

Given the long time since my last post, before moving to the main subject of this Blog Post, I will first give you an update on where we are with MCS Formulas:

As I stated earlier when the company started its activity (Ref.), we will become one of the Worl’s top food supplement company in size, and with that we will be able to have a sizeable positive impact in the oncology World, through our actions as a Social Enterprise.

Moving along this line, during the past year, at MCS Formulas we have succeeded to put in place a range of products, many of which are the best in the World in their category, and we have documents to support that for anyone questioning this statement. Example of such products are Boswellia MEGA AKBA (containing the largest amount of AKBA available in one capsule), Broccoli Ultra (containing the largest amount of Sulforaphane available in one capsule), Genistein Ultra (containing the largest amount of Genistein available in one capsule), and many more such products. In addition, we have put in place a very effective logistics process, to support fast shipping to most countries around the World, collaborating with outstanding partners such as FedEx and UPS.

So we have super products, good knowledge and top service, all glued together by the care, ethics and hard work that define us.

As a result, we have developed MCS Formulas, so that in multiple areas it is stronger than major supplement companies, in terms of products and speed of shipping for international and intercontinental orders. 

The quality level of our work and dedication is reflected by the reviews posted on our page by kind customers (collected by a 3rd party well-respected company, outside our influence), as well as by our partners, such as clinics, top wellness hotels, healthcare practitioners and coaches that are using our food supplements, because of their increased effectiveness.

To get to and maintain an increased level of effectiveness, we need to constantly address multiple points at the same time, i.e. the source of the raw material, the purity of the raw material, and the formulation of the supplement in the capsule, including the amount of active ingredients, and solutions to support their bio-availability. In addition, most of MCS Formulas supplements do not contain additives.

With this, I would like to take this opportunity and thank you so much to all those appreciating and supporting us, and promise I will continue to do the best I can, so that we provide the best, with the best intentions through everything we do. There is a lot of hard work to put in all this, but I promise you will see more and more great results as we move forward, related to both MCS Formulas products and its contribution as a Social Enterprise. 

Anyone interested in more information on some of the above points, is welcome to contact me, and it will be my pleasure to respond. Both positive and constructive criticism are very welcome.

Moving on to the subject of this post, I do believe Ivermectin is one of the most relevant repurposed drugs in terms of its potential to add value in oncology. However, this is not the only reason that motivates me now to write about it. Instead, it is because of multiple questions of people regarding the most common and relevant Ivermectin doses used in oncology. As a result, the post below will give a specific attention to that aspect. Next to that, the other very important reason to me is that positive case reports started to emerge, after its use by oncology cancer patinets.

As always, please note this is not a medical advise. Instead, here I am only consolidating scientific literature (biased by my own knowledge, approach and limitations). It may be used as input in the discussions with your oncologist, but it should not be directly implemented without the help of a medically trained person. Therefore, as always, this post and related conversations come with my Disclaimer.

Introduction

Ivermectin is an FDA-approved drug used to treat health challenges related to parasitic worms such as intestinal strongyloidiasis (a chronic infection), onchocerciasis (also called river blindness), and other parasitic infections. It is also approved as a topical treatment for head lice and skin related conditions such as rosacea. It has also been shown to have anti-viral activity against a broad range of viruses (Ref.1, Ref.2, Ref.3)

It has been used in a safe manner since 1970s, by over 200 million people worldwide (Ref.), and its contribution to saving human lifes has been recognised via the 2015 Nobel Prize in Physiology or Medicine (Ref).

During 2020, Ivermectin has come into the spotlight after the discovery of its antiviral potential (I will not name the virus here so that the page is not downgraded by the search engine algorithms), by an Australian academic team (Ref.). Following that report and after performing research on the subject, I have included Ivermectin during May 2020 in the list of drugs and supplements with potential against the virus. The article can be found on this website, published on March 13th 2020.

I decided so fast to add this drug on the list of drugs with potential against the virus that caused the recent pandemic, as I was positively biased by my previous research related to this drug. And it seems I was right in my assessment, given all the positive results that have been observed after Ivermectin has been implemented during the past years to address the viral infection.

Now, I would like to make a similar statement regarding the anti cancer potential of Ivermectin. According to the scientific literature that we will address below, Ivermectin is one of the drugs standing on top of the list of repurposed drugs in oncology, due to its outstanding potential to fight cancer.

Indeed, this is a drug that stood out in my research of the scientific literature since 2014. At that time, there was not much information available on Ivermectin application in oncology – only reserch in the laboratory. In terms of application of Ivermectin outside the conventional use, the most relevant source of information I found at that time was by Dr. Simon Yu, and MD on Internal Medicine from the USA, intensively using Ivermectin to cure autism in children (Ref.).

During the past years, occasionally, this drug came up in our discussion either in the Blog or in the Forum section, in the cancer context and more recently in the virus-related discussions. However, I never allocated time to address the drug in details, because there was no case report published in a peer review article to demonstrate the potential of this drug against cancer in real life, beyond the academic research in the lab. At least not to my knowledge.

Fortunately, also during the past years we have seen an increased attention of the medical and scientific community towards the anti-cancer properties of this drug. In this context, an article has been recently published, including multiple positive case reports, demonstrating that Ivermectin can add value to the life of cancer patients. Therefore, this is a good time to address this drug, with the hope and expectation that many more cases like these will follow. 

Note: while going through the literature, I found one more publication on the use of Ivermectin on cancer patients, that will be shortly addressed below.

Ivermectin in Oncology – The Science

In laboratory, Ivermectin has been shown to be able to kill cancer cells of many types, such as

  • Breast Cancer (Ref.1, Ref.2, Ref.3)
  • Ovarian Cancer (Ref.1, Ref.2)
  • Prostate Cancer (Ref.)
  • Colorectal Cancer (Ref,)
  • Brain Cancer (Ref.1, Ref.2, Ref.3, Ref.4)
  • Renal Cancer (Ref.)
  • Leukemia (Ref.)
  • AML (Ref.)
  • Hepatocellular carcinoma (Ref.)
  • Lung Cancer (Ref.1, Ref.2)
  • and many others.

However, many substances have been shown to kill cancer in laboratory. So why woudl Ivermectin be more relevant?

Ivermectin, stands out in my view because it acts as a strong ionophore and up-regulates chloride channels (Ref.).

Indeed, Ivermectin is known to increase the activity of glutamate-chloride ion channel, increasing the influx of chloride ions inside the cells, and consequently blocking signal transmission between neurons and muscles. This is the main mechanism which is responsible for its antiparasitic effects. At a higher concentration, ivermectin also stimulates chloride channels in mammals.

While as we will see below Ivermectin works through multiple anti cancer mechanisms, I believe its interference with ion dynamics across cellular membrane is the most important property responsible for the anti cancer effects of Ivermectin (Ref.). This is because, the over activity of cancer cells vs normal cells requires an intense movement of ions outside-in and inside-out of ions such as Potassium, Chloride, etc.

During the past years, I have discussed why this ion dynamics is so important and in that context I addressed outstanding Ionophores such as Salinomycin or Ion transporters inhibitors such as Bufalin. Other ion transporter inhibitors known to have outstanding anti cancer properties are e.g. Oubain, Oleander, Digoxins, also known as Cardiac Glycosides.

Cardiac Glycosides, act on the K/Na exchange while Salinomycin mainly on Potassium. That is different compared to Chloride that is the initial target of Ivermectin. However, no matter which “string you pull” you end up affecting the dynamics of many other ions. So when you act on Chloride, you will end up also affecting Potassium and the other way around.

Actually, this is what electro-magnetic fields are also doing and this is why they have potential to affect the development of tumors, as they mess up with the ion dynamics. In turn, interference  with ion dynamics can have impact on e.g. intracellular pH and as a result impact functionality of various enzymes, and at a more general level interference with major intracellular pathways and mechanisms.

As a reminder, Salinomycin remains the most effective anti cancer drug I have seen, and I believe Ivermectin is not far from that in terms of potential. However, because of its accessibility, well known safety, and ease of implementation Ivermectin may be even more relevant.

Coming back to Chloride that is affected by Ivermectin, it may be interesting to remember that Chlorotoxin found in scorpion venom (see my post on scorpion venom) (Ref.) can also inhibit chloride channels. This leads to the opposite outcome in terms of Chlorine ion dynamics but the result is still killing the cancer cell (Ref.). This is a similar story with that of pro-oxidants and anti-oxidants treatment strategies in oncology. No matter which one you pick it will be effective against cancer as long as it is done in a coherent manner, so that the treatments used they are either pro- or anti-oxidants. Same here with Chlorine intracellular accumulation (by Ivermectin) or depletion by scorpion venom. We shoudl chouse either one, or the other but not both at the same time.

Nevertheless, academic research has indicated that Ivermectin can address many more mechanism that can lead to tumor suppression. Whether all or some of those mechanisms have at the base its ionophore activity remains to be seen. Nevertheless, the list of anti cancer mechanisms related to Ivermectin is outstanding:

  • Can trigger “Immunogenic Cancer Cell Death”. This is a form of cancer cell death that “wakes up” the immune system and therefore initiates an immune response. As a result, it has been proposed that Ivermectin coudl be a great combination with forms of immuno therapy such as checkpoint inhibitors. (Ref.)
  • Downregulates glutathione S-transferases (GSTs) and vascular endothelial growth factor (VEGF) (Ref.)
  • Potentiated activity of anti–androgen receptor and anti-EGFR drugs (Ref.)
  • Inhibited cancer stem‑like cells (CSC) (Ref.)
  • Inhibits angiogenesis (Ref.)
  • Inhibition of metastasis (Ref.)
  • WNT pathway inhibitor (Ref.1)
  • Increased reactive oxygen species generation that was functionally important for ivermectin-induced cell death (Ref.)
  • Microtubule inhibitor (Ref.)
  • Multi Drug Resistance Pumps inhibitor (Ref.)
  • At a higher dose, Ivermectin can inactivate the protein kinase PAK1 and blocks the PAK1 dependent growth – PAK1 is critical for cytoskeleton reorganization and nuclear signalling. PAK-1 kinase is required for the growth of more than 70% of human cancers (Ref.) This activity is similar to Caffeic Acid from Propolis.

This amazing list of activity explains why Ivermectin has such as large anti cancer potential.

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Ivermectin in Oncology – First Results in Humans

Source 1: When searching for new treatment options in oncology, in order to identify the value and not look at the noise, its best to look for two important aspects: clear science and at least a first indication that the treatment option has been applied in humans with some success. In other words, we look for good knowledge and signal of activity.

While the science is strong when it comes to Ivermectin, until the recent years we had no case report published in the scientific literature that would support the expectations from science. 

Fortunately, very recently a paper has been published where Ivermectin has been used as part of a drug cocktail in patients with no effective treatment options (Ref.). In this paper, 3 cases have been discussed and in each of the cases benefits have been observed after just adding a low dose of Ivermectin:

Case 1: A 69-year-old female diagnosed with invasive breast cancer underwent left breast partial mastectomy, but bone metastases and pleural dissemination appeared. After conventional treatments have become less effective, and intolerable side effects appeared, her doctors decided to switch to a combo of dichloroacetate, omeprazole, and tamoxifen. This helped to relieved her symptoms (bone pain, shortness of breath, and general fatigue) instantly but not completely. After adding a tablet of 12 mg ivermectin per day the pleural effusion has been stabilized and the tumor marker CEA started decline from 12.9 to 7.3, and cancer antigen 15-3 (CA15-3), from 302.3 to 229.4 in three months. (Ref.) Note: my understanding is that the Ivermectin has only been used here one time per week.

Case 2: A 54-year-old male was diagnosed with right femur osteosarcoma. While on conventional treatments, lung lymph node metastases and pleural dissemination appeared. At that point he could not walk out of his house himself because of shortness of breath and severe pain. His doctors, decided to switch to a combo of dichloroacetate, omeprazole, tamoxifen and ivermectin at a dose of 12 mg 2x/week, on Day 1 and Day 4. After only one cycle, all the symptoms were relieved dramatically, and he could go to the clinic on foot by himself. (Ref.)

Case 3: A 54-year-old male was diagnosed with right lung adenocarcinoma. While the chemo was initially effective, gradually it became less effective and metastases (bone and brain) appeared. His doctors, decided to switch to a combo of dichloroacetate, omeprazole, and ivermectin at a dose of 12 mg one time per week. However, his symptoms (cough, shortness of breath, pain, and appetite loss) did not improve. After increasing the dose of Ivermectin to 12 mg 2x/week, the symptoms were relieved. (Ref.)

While the results presented in this report may not be impressive, they demonstrate that Ivermectin has the potential to add good value to the life of cancer patients. 

The question is what can we do to maximize its value. One aspect that becomes imidiatly clear after reading the report above, is that the dose and the ferquency of administration used was very conservative. The other point is that delivering Ivermectin more targeted to the tumor via intravenous administration or rectal administration could maximize the effects of Ivermectin.

Source 2: After digging more into the literature, I found another very important report, on the use of high dose Ivermectin in paediatric patients with refractory AML. (Ref.). In this case, a 1 mg/kg dose has been used daily for six months with no major side effects, while bennefits have been also observed.

Source 3: In addition to the above, Dr. Simon Yu states “If you have Medically Unexplainable Symptoms (MUS) or cancer, you may consider trying Ivermectin, deworming medication.”. (Ref.) In another post by Dr. Simon Yu he stated “I have experienced some dramatic responses for medically unexplained symptoms and some cancer cases.”. He also stated “monthly de-worming for medically unexplained symptoms or for cancer patients might be a better solution”. (Ref.) Dr. Simon Yu also liked to combine Ivermectin with Praziquantel another of his favorited anti parasitic drugs. 

Safety & Pharmacokinetics

  • Ivermectin provides a high margin of safety (Ref.). 
  • The half-life of ivermectin in humans is 12–36 hours, while metabolites may persist for up to three days (Ref.)
  • The peak plasma level seems to be achieved after about 4 hours, when taken orally (Ref.)
  • In line with the half-time, accumulation of ivermectin given every fourth day is minimal (Ref.)
  • While in normal conditions it will not cross the blood-brain barrier, hyperinflammation or drugs influencing P-gp may change that making BBB leaky. Long term administration of the drug may also influence that. Therfore, it is always best to increase the dose to the daily target dose step by step while observing if any side effects occurs.
  • Best administered with food (Ref.)

Application and Dose*

According to the scientific literature, Ivermectin has been administered so far orally, intravenously and rectally (Ref.).

Nebulized Ivermectin has also been proposed for direct delivery to the lungs and this could very much make sense for patients with tumors at the lungs (Ref.). In this case the authors have proposed solving Ivermectin in ethanol as described in the article. This is not a new concept to be discussed on this Blog as we have discussed similar concept for e.g. 3BP (Ref.).

The most suitable daily dose of Ivermectin as a repurposed drug in oncology has not been well defined yet. Therefore, before getting to a conclusion, we need to look at multiple refernces to identify the dose that could be high enough and safe enough to be used.

  • a first reference point when it comes to the use of Ivermectin, is dr. Simon Yu. To my understanding some of his slides are suggesting that a common anti parasitic dose in his view is 12 mg 3-4x/daily for 10 up to 30 days (Ref.) I would assume this is for a person of 70kg, that woudl indicate a 0.7 mg/kg daily dose.
  • on the other hand, the study referenced above, showing positive results in oncology, based on a daily dose of 12 mg, given one to two times per week (Ref.)
  • indeed, a recent systematic review, including a meta-analysis, has shown that adverse effects following single-dose treatment with up to 0.8 mg/kg of Ivermectin occur without significant differences of frequency or intensity to those at regular currently approved doses (Ref.)
  • here is a paper published in The Lancet in 1994, where patients have been treated with Ivermectin doses up to 1.6mg/kg given as subsequent injections at weekly or biweekly intervals. ” No clinical adverse effects were noted in any of the patients, including the one who received ivermectin for 12 weeks. In fact, many reported improved sleep, less depression, and better bowel and bladder function during the trial.” (Ref.)
  • a recent review on Ivermectin safety, also states that there is “no difference in the severity of the adverse events between standard (up to 0.4 mg/kg) and higher doses of ivermectin. Organ system involvement only showed an increase in ocular events in the higher-dose group in one trial for the treatment of onchocerciasis, all of them transient and mild to moderate in intensity.” (Ref.)
  • another extensive study in humans using an Ivermectin dose of 0.6 mg/kg/day for 5 days, reported on both the safety and possible efficacy of high dose ivermectin as an anti viral (Ref1, Ref.2.)
  • finally, Ivermectin has been used at a dose as high as 1 mg/kg in pedriatic patinet wih AML, for six months, with no major side effect (Ref.)

Based on the above, I would consider using

  • a dose of 0.6 mg to 1 mg/kg/day,
  • taken once a day (single dose), 
  • with food

If active cancer, I would take it in one of the following ways:

  • 5 days ON and 2 days OFF, or
  • 20 days  ON and 10 days OFF, or
  • if highly active cancer, I would take it continuously, at least in the first months

In non active cancer, I would take it in the following way: 10 days ON and 20 days OFF, repeat this during the second month so that there are two cycles performed, one after each other. I would do this, 2x/year.

I like the idea to combine it with one more anti parasitic such as Praziquantel, as ofte done bt Dr. Simon Yu.

NOTE:

The doses discussed above are coming from references following its use in humans, in some cases for as long as 6 months in pediatric patients. That sounds as a good safety profile at that dose.

Nevertheless, it must be made clear that the statement on the safety of the drug at normal dose comes from a very large set of data related to its use in humans, while the safety as stated at higher doses comes on very limited set of data. Therefore, I would never go to the target dose immediately when starting Ivermectin. Instead, if the target dose would be 1 mg/kg/day, I would start first with 0.1 mg/kg/day, and move step by step towards the 1 mg/kg/day during a few/several weeks. This approach will help to identify potential side effcets. And that, done with the support of a medical doctor.

Other References

Current state and outlook for drug repositioning anticipated in the field of ovarian cancer 

Ivermectin as an inhibitor of cancer stem‑like cells

Drug Repositioning for Cancer Therapy Based on Large-Scale Drug-Induced Transcriptional Signatures

*Disclaimer

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

Please read an extended version of the Disclaimer here: https://www.cancertreatmentsresearch.com/?page_id=1794

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133 thoughts on “The Magic of Ivermectin in Oncology

  1. I read the science article you referenced under the ” Lung Cancer ” category.
    I could not find any mention of lung cancer. Only colon cancer.

      1. Hi Daniel… I’m tryin to reach out for information. My husband has Terminal HCC & I want to try Ivermectin but not sure of how it will react with his Immunotherapy he is currently on. I’m desperate for answers. Will you please respond. Thanks

      2. Dear Daniel,

        I am writing this note to express my appreciation for what Daniel Stanciu has done with his life to date which is remarkable on a number of different fronts.

        I would like to recount how I met him and perhaps this will help some of those who read and benefit from his websites and blogs understand why he has made a difference to so many cancer patients and their families and friends and continues to do so.

        I am a professor of Cell Biology at the University of Miami, trained in Oncology at the Dana Farber Cancer Institute at Harvard Medical School, and have focused my cancer research career on chemotherapy, drug resistance and for the past 23 years on increased glucose metabolism in cancer cells. I have been developing a common analog of glucose, known as 2-deoxyglucose (or 2-DG for short) which inhibits the utilization of glucose, to take advantage of this natural trait of increased glucose uptake of most cancers to treat patients and have become very familiar with those in this field.

        When I happened to read the writeup Daniel did on 2-DG I was curious to know who he was and why I had not seen his work in this area of cancer research before? The knowledge that he had of the mechanisms by which this sugar analog works was as good or better than most in the field, so I decided to contact him.

        Within minutes of speaking with him I knew that this individual was very special. His intellect, motivation and extraordinary ability to process information upon reading the medical literature and formulate logical scientific based ideas that could be helpful to stage 4 cancer patients who had reached limitations with standard of care, make him quite unique. In my years in the medical field I have encountered few if any that are like him.

        The fact that he had no formal training in cancer, attaining a PhD in physics adds to this uniqueness. However, in addition to these outstanding qualities and abilities, his genuine caring of others and devoting his life to helping those that he can, make him truly valuable to the needs of so many that are suffering cancer.

        To this point , the enormous amount of time devoted to reading the literature, developing a website where patients contact him, setting up appointments to discuss their particular type of cancer and what he can add to their treatments in the form of supplements and or repurposed drugs without charging for his time is truly extraordinary.

        Most, if not all, those who offer advice similarly, charge upwards of $500/hr for their services.

        Having left a six figured salary from a well known (non-medically-related ) company to devote himself to this purpose, I asked him how long he could sustain himself without a salary and he told me based on his savings he would probably run out of money after a year or so.

        So in order to be able to continue doing what he is so uniquely suited for, he decided to start a supplement company where once established he would devote a good percentage of the profits to cancer research focused on alternative treatments. In the short time he started this tremendously time consuming task (almost single-handedly) he has succeeded in building an outstanding high quality company that continues to grow on a daily basis.

        I wrote the above to give you my perspective (that many of you may already have) of Daniel.

        When I learned of his journey with his beloved wife and how by his efforts he kept her alive, far beyond the expectations of the oncologists that originally diagnosed her with a rapid deadly form of cancer, I understood how he was positioned so that we could work together.

        Based on all he knew about the limits of conventional treatments and how complimentary additions could augment their efficacy we discussed the possibility of developing and offering a metronomic protocol of delivering 2-DG in a manner that would avoid the insulin inducing response we had seen in our Phase I trial.

        Had we not met, I can safely say that the many patients that are now using 2-DG in several different countries would not have access to it and our protocol describing this type of delivery system.

        With the announcement that the government of India approved 2-DG as a drug to treat COVID-19 the interest in it has accelerated.
        The understanding that glucose is not only a vital energy source but it also supplies the building blocks required for a cancer cell to replicate can be applied to viral infections in general as follows:

        Since a virus (being as small at it is) cannot replicate on its own, it must us a cell’s “machinery” to do so. Once it infects a cell and orchestrates the cell to produce more virus it increases the cell’s uptake and metabolism of glucose as the source of the building blocks required to make more virus.

        So cancer cells and viral-infected cells share this common trait of increased glucose uptake and metabolism.

        Thus, 2-DG as an analog of glucose, and inhibitor of its metabolism, exploits this natural characteristic of cancer and viral infected cells by accumulating selectively in these two cell types. Since 2-DG by its nature cannot be further metabolized it ends up blocking the use of glucose as both an energy source as well as the necessary building blocks effectively inhibiting cancer and viral replication.

        Thus, Daniel’s contribution to expanding the use of 2-DG in cancer patients clearly will continue to be beneficial to this group and appears to hold promise for expanding its use for viral diseases.

        I hope this short write-up adds to the perspective of what many of you must have experienced in either visiting the websites and or talking with this extraordinary human being!

        With much appreciation,

        Ted

        Theodore J. Lampidis, PhD
        Professor
        Department of Cell Biology
        Director of Tumor Biology Course 765
        University of Miami, Miller School of Medicine
        & Sylvester Comprehensive Cancer Center Member

        1. Dear Prof. Lampidis,

          Thank you so much for this very nice surprise.

          I very much appreciate it as I also very much appreciate our collaboration. It has been, and it is an honor to be able to work with and learn from you, and I hope we can continue this work and do our best to add as much value to life. I am sure we will be able to do a lot more as we move forward.

          Thank you very much again, and I am looking forward to our next call!

          Kind regards,
          Daniel

          1. certainly deserved praise, D!

            I wonder if lactate and glutamine inhibition would enhance 2-DG treatment. In theory, it seems to be a reasonable strategy, as the cancer cells are forced to switch to another energy source and if possible use reverse glycolysis?

      3. Hi Daniel
        My husband is starting CAPOX chemotherapy for colon cancer….our goal is to prevent multiple drug resistance and of course cure from cancer
        He plans on continuing fenbendazole and we also want to take Paw Paw and ivermectin

        Both paw paw and ivermectin prevent multiple drug resistance but I wanted to make sure they don’t CANCEL EACH OTHER OUT🤷‍♀️

        Also what would be the dose of ivermectin if taking for all oncology benefits

        Daily????
        Twice weekly???

        We have 12 mg tabs

        Your reply is so appreciated ❤️

        1. Hi Missy051295,

          I am sorry to hear about the challenges and I hope your dear husband will be well soon.

          Regarding ivermectin dose and frequency, I shared my view and the information I found in the article above. That should give you a good feeling how I am thinking in terms of administration procedure.

          One example was referring to a dose of 0.6 mg per day for several days as safe. That could be a fair target dose for daily administration.

          Kind regards,
          Daniel

      4. Hello sir great read, curious if you have come across anything involving ivermectin and Non Hodgkin’s lymphoma and or large and small B cell…. Etc? Trying to establish a treatment for my father, no treatment plan as of yet and no Mets…. Thank you.
        Brandon Briskin

  2. Thanks for the great article. I have Stage 4 Triple Neg. Breast Cancer I have been taking Ivermectin for the past 5 month I worked up to 25mg I do 5 days on 2 off for a month or 2 and then usually take 3 weeks off. I see you mentioned something called Salinomycin? I never heard of that is that a prescription antibiotic? Does it work well if taking Ivermectin? Is there a dosing for it , for cancer? Do you have it available for sale ? Thanks, Nicole

    1. Hi Nicole,

      Thank you for your feedback and question.

      First, I should say that my investigation of the oncology space goes beyond supplements, as my goal was to find a solution to cancer for my wife and today to help others. In that context, I researched many drugs as well, but also new substances.

      Salinomycin is an antibiotic used for animals so far. So it is outside the scope of MCS Formulas, which is a supplement company only. Also, if this woudl be one of the MCS Formulas product, I woudl not speak about it so freely since it woudl represent conflict of interest.

      Fortunately, Salinomycin is not an MCS Formulas product, so I can speak freely about it.

      Back in 2009, Salinomycin has been found as one of the most effective substance against Cancer Stem Cells. Latter, in 2011 has been given first time to humans at Heidelberg Cancer Center (as I remember to breast cancer and ovarian cancer patients not responding to chemo). That helped a lot the patients and a report has been published in the scientific literature.

      In 2014, some doctors from USA were applying in private clinic in Colombia Salynomicin in combo with 3BP on a lung cancer patient who in one month was cured. They published the results that attracted a lot of attention at that time.

      I wanted to have it for my wife as it was very promising for her based on he literature, but it was too expensive and performed in only few places around the World. It had to be done intravenously, and the price was somewhere in the range of 50k/month.

      So I went into the details of the patents and all info I could access from scientists and doctors around the world, and with that I succeed to access this substance, formulate the intravenous solution and with the help of clinics in countries where that was allowed we could start using for my wife. In that way, the cost was much more affordable – more than 10x lower vs 50k. The results were very good and that contributed to her life extension.

      I also decided to share for free all the knowledge about formulation and administration protocol with clinics around the world who like to use it, and I am still doing that.

      Many years ago, I addressed Salinomycin here: https://www.cancertreatmentsresearch.com/salinomycin/
      and here: https://www.cancertreatmentsresearch.com/discussion-on-salinomycin/
      in case you like to read some extra info. I did not share the formulation and administration protocol online as I do not want to encourage people to do that alone and hurt themselves, but I am ready to support people (for free) with info if they have doctors willing to help them with the administration.

      When MCS Formulas will have the capability to do that, one of the first clinical trial to be supported will involve Salinomycin since I believe it has great potential.

      I hope this gives you a bit of a context so that you can read more about Salinomycin.

      Kind regards,
      Daniel

        1. Hi,

          I knew one clinic, but you woudl need to check if they are still using it. If you e-mail me, I will share the name in case they prefer to keep such treatment options in the discrete space and not publish online.
          Mark from Patient led oncology research FB group may know some more.

          Kind regards,
          Daniel

      1. Hi, my best friend has small cell lung carcinoma. He just got out of the hospital with pneumonia. He completed the chemotherapy and radiation in December. They have not found the cancer in his lung only in the lymph nodes. The lung cancer was diagnosed by a biopsy from the enlarged lymph nodes. He does not want to do any more chemo or radiation. I was reading about the success they were having with large doses of Ivermectin. I see you have done a lot of research with Ivermectin and was wondering if you would be open to a telephone conversation with me so I can provide him with the correct information on how to use Ivermectin or maybe the MCS formulas you talk about above. I know every cancer is different but the Ivermectin may be a fit for my friend. I used my email to set-up an account so you can reach out to me there, if you are willing to provide additional information. Thanks, Lori

    1. Thank you!

      I could buy it over the counter some years ago from Thailand. It depends on the country or the state if you are in the USA. Some states have it over the counter https://www.einnews.com/pr_news/572339675/ivermectin-now-available-over-the-counter-from-pharmacists-in-tennessee

      However, the best would be to get the help of a doctor with the implementations, and he will be able to write a prescription if needed. There are many doctors around the World that are positively biased towards the use of repurposed drugs in oncology.

      Kind regards,
      Daniel

  3. Hi Daniel, really great article. I’m just not so sure about your claim that Ivermectin can cross the blood-brain barrier(BBB). The article you reference along with that claim, I could only get the abstract for but it clearly says “inability to cross the blood-brain barrier in humans and other mammals”. I’ve looked into other papers in regard to it’s brain permeability and it seems that Ivermectin inhibits P-glycoprotein, which is responsible for drug resistance and the inability for things to pass the BBB. Apparently that might allow greater brain concentrations. Did you find any papers looking at in vivo use of ivermectin on brain cancers? I’m curious how it affects brain cancer cells when ivermectin has to first cross the BBB. I found one where they did subcutaneous xenografts with glioma cells but not in the brain.

    1. Hi hbotha,

      Thank you for the kind feedback as well as for the point related to BBB.

      You are right – in normal conditions and known short term doses Ivermectin is not expected to cross BBB to a relevant level, but as you said and is shown in literature, in special conditions that can happen. That is why the remark about BBB is added in the Safety and Pharmacokinetics, so that we are aware that may happen give that the doses used in oncology patients are both higher and applied on long term. In rare cases, this can lead to accumulation and possible cross of BBB, which in turn can lead to important side effects.

      I will add extra details to the point on BBB above, to clarify.

      If I find more studies related to Ivermectin in brain tumors, I will let you know. I woudl expect Ivermectin will be indeed relevant against brain cancer since Chlorine activity is specifically relevant in brain tumors, and up regulating or down regulating related transporters will interfere with the normal function of the tumor cells. However, Chlorotoxin from scorpion venom may be even more relevant for brain tumors since it can cross BBB in normal conditions https://www.nature.com/articles/srep19799

      Kind regards,
      Daniel

    2. I expect, when coadministered with the strong P-gp inhibitors such as Ketokonazole or Verapamil will increase its BBB penetration – relevant for brain tumors but risky from potential side effects point of view.

    3. There are numerous breeds of dogs that cannot take IVM because it absolutely does cross BBB & kills them. These breeds all have MDR1 gene. I’m sure some humans can have similar issues. So I agree with. Daniel, that if you take it, start low dose and work up. I use a lot of herbal & natural therapies for animals (and myself), and that’s my rule of thumb….start low and work up, esp if I’m trying something that I’ve not used before or has a profile of toxicity that is dose dependent ie black walnut etc. Never assume that one size fits all. We are all individuals. This is a big mistake that pharma & gov make ALL the time.

  4. Of note, the relative safety of IVM use comes from the fact we don’t have any glutamate-gated ion channels outside of the brain and spinal cord, and only a low dose is taken just one time for its intended use. If and when IVM crosses the BBB, IVM will bind to the glutamate-gated ion channels in the brain! At the high continuous doses mentioned in this article, the safety profile of regular IVM use isn’t relevant IMO. For example, some dogs are genetically hypersensitive to ivermectin and it easily crosses the BBB and can be lethal to the animal.

    1. Hi Johan,

      The doses discussed above are coming from references following its use in humans in some cases for as long as 6 months in pediatric patients – while I can only speak based on literature as I do not have direct experience with the drug, the available references do not report any major side effects at that dose.

      Nevertheless, it must be made clear that the statement on the safety of the drug at normal dose comes based on a very large set of data, while the safety as stated at higher doses comes on very limited set of data. Therefore, we should always move in small steps towards the target dose and observe potential side effects. And that, best done with the support of a medical doctor.

      I added this point in the post above to make it clear. Thanks for your remark.

      Kind regards,
      Daniel

      1. Hi D., agreed, this is a drug that is quite safe at the one-time low dose but for higher doses, this shouldn’t be undertaken without proper medical supervision as it’s not without danger. Even at relatively low doses, severe toxicity can occur albeit rare:

        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5929173/

        The reported dosages of ivermectin ranged between 3 and 24 mg. Most of the cases reported a one-time dose or two doses separated by 1 week.
        Examples of serious neurological adverse events reported included such terms as unable to walk, consciousness disturbed or depressed level of consciousness or loss of consciousness, seizure or convulsion, encephalopathy or coma, and tremor.
        including presence of the drug in brain tissue.

        Good to see the progress with MCS Formulas, great job!

        1. Hi Johan,

          Yes, you are right. I consolidate and share the info above to be used as input in the discussion with a medically trained person. Even Paracetamol can be dangerous at high enough doses.

          Thank you for the positive feedback on MCS Formulas.

          Kind regards,
          Daniel

  5. Dear Daniel,

    I’m happy to see you writing about another potential weapon against this cursed disease

    It’s extremely helpful especially for people who cant’ afford expensive or publicly unavailable drugs, very thankful for your great commitment towards helping people around the world, bringing back hope for those who need it

    I didn’t show-up for the past few years as I was very busy at work, trying to distant myself from cancer world

    Recently I have started to dedicate few hours a week to learn about cancer causes and how to live a healthy life to prevent it and other chronic diseases.

    But unfortunately, the anxiety and fear from cancer started to grow more in my mind and I can’t even sleep like a normal human

    I can’t tolerate to see my loved ones face this terrible disease, preventing cancer becomes like fighting an invisible enemy who can strike at anytime

    I wish if we have enough time to talk together, but your time is critical to those who really needs help.

    Thanks a lot, keep it up.

    1. Hi Emad,

      Very nice to hear from you!

      There is no reason to live with fear – not of cancer and of anything – we do the best we can with everything and the rest is in the hands of God. It woudl be my pleasure to speak with you on the phone. Please e-mail me, and we can agree on a time suitable for both of us.

      Kind regards,
      Daniel

  6. thank you VERY much for your coherent, cohesive, and thoughtful insights re: IVM and cancer, and MOST especially on dosing. I’ve been reading and researching for the past week and was coming with a plan akin to what you posted – which made me feel good in that it assured me i was on the right track in terms of my conclusions. My mother had cervical cancer, then breast cancer – lumpectomy, the standard treatments. 5 years cancer free. so they said, in feb with a persistent cough that wasn’t clearing with zpack the short version is her breast cancer had metastasized, now in lymph, lungs, liver and pancreas. she found the Joe Tippens fenbendazole protocol and has been on that since March. last week she got covid. I had already made sure she had IVM on hand but in the process of nailing down a good dosage i came across all the published cancer research – i am floored that it’s kept so hush hush but then as we know, it doesn’t make money for big pharma, keeping people ill is how they make bank, but i digress. i’d found the .2-.6mg/kg but your article here has really helped me figure out what to tell her and how to get her from a low dose to a more effective higher dose. i thank you for your courage in printing this!
    i’ll be heading over to MCS to see what’s there to help with this battle.
    again, my thanks and appreciation for what you’ve provided here

    1. Dear Cyd,

      Thank you for your comment and words of appreciation.

      I hope you will find the way to an effective treatment strategy and that your mom will get better and better.

      I do my best to consolidate the available info, but as discussed above we have to keep in mind that while higher doses of Ivermectin have been suggested to be safe, the data is very limited, and we don’t know how that can work out for other people. Therefore, it is recommended to have the help of an integrative oncologist while implementing this.

      Kind regards,
      Daniel

    1. Thank you Piterpan,

      Can you please share the link where he speaks about that? I woudl like to understand in details what are the mechanisms at play in his view to induce that.

      Kind regards,
      Daniel

  7. Great article Daniel! Once again I send you my congratulations! I remember a few years ago how ivermectin excited me about its enormous potential against cancer…. I found the problem that they mention above, it does not cross the bbb and if it does (many glioblastomas have it altered) it can produce toxicity and I was afraid of give it to my mother

    kind regards

    1. Hi Manuel,

      Thanks for the feedback. Yes, I remember when you were considering Ivermectin.

      The hope for targeting brain tumors is that there is a working latitude in which the dose reaching the brain is low enough not to cause major side effects (that can be controlled when the dose is increased step by step) and high enough to induce antitumor effects. This is the typical investigation that woudl be done in a clinical trial setting.

      Kind regards,
      Daniel

  8. I wonder if you now where a person might obtain nebulized Iver. This makes sense to me, given Iver’s poor absorbability. This would greatly enhance its absorption. But lacking a source of nebulizer Iver, I’m experimenting (nervously) with Iver dissolved in vodka and nebulized with distilled water and baking soda. So far, no problems. I have lung mets I’m treating with several nebulized formulas.

    1. Dear Stan,

      According to literature, Ivermectin is expected to support the effectiveness of many chemo types.
      Back in 2016, scientists at Johns Hopkins University have even suggested to me (for me wife) to use it prior to chemo as well, to increase its effectiveness.
      However, I woudl always at least check the potential interaction of Ivermectin with the specific chemotherapy using drug interaction checkers such as this one https://reference.medscape.com/drug-interactionchecker?src=google

      Kind regards,
      Daniel

  9. Hi Daniel I was given less than a year to live with prostate cancer in 2017 turned down radiation as it had spread to my spine which they could not fix. I have tried everything and very low carb diet worked and still does. I found metforman by accident which reduced the cancer and have used cucumin for years and now have been using ivermectin for the last year. I get ivermectin from goodhealthlive.com which comes from India. The thing I found was there was no regular information regarding alternatives so I set up a blog to help others. I subscribe to your blog which has helped greatly thank Stew

    1. Hi Stew, thanks a lot for writing about your positive results. That is so nice to hear. Please share your blog here so that others can read that. I hope, on your blog, you also write about the treatments options you used. Thank you!

    2. Hei Stewman , I have prostate cancer since 2006 , first bone met in 2010, I was using different approached officials and off the label.
      I purchased ivermectin and used first 10 days 12mg – no visible results PSA increasing, today increased to. 2x12mg day.
      What is your experience with IVM, dosage , side effect? Have a nice day best regards Adam

    3. Hei Stewman , I have prostate cancer since 2006 , first bone met in 2010, I was using different approached officials and off the label.
      I purchased ivermectin and used first 10 days 12mg – no visible results PSA increasing, today increased to. 2x12mg day.
      What is your experience with IVM, dosage , side effect? Have a nice day best regards Adam

  10. Hi Daniel, the biggest problem of all is to find and then afford the integrative oncogist that accepts IVM as part of a protocol. I had to enroll with Care Oncology Clinic here in the U.S. because I couldn’t find a single Integrative Dr. anywhere near where I live to treat me from Follicular Lymphoma grade 3A. It is costly. Only 1 virtual consultation with one of their oncologists that prescribes Jane McClelland ‘s “beginner’s protocol of Mebendazole, Metformin, Atorvastatin and Doxycycline. But I would like to add Ivermectin to the 2nd part of the 3 month treatment were I stop the Mebendazole and start w/Doxycycline, Metformin and Atorvastatin. I took IVM during the entire “covid” period as prevention 1/week ON AN EMPTY STOMACH, W/ ONLY WATER AND 2 HOURS BEFORE BREAKFAST and it worked great. What I need to know is if for CANCER PATIENTS, the IVM needs to be taken with a fatty food like Mebendazole or Fenben that I aso took for almost 2 months before I started the COC protocol with Mebendazole. Thanks Daniel for all the information that you kindly provide. I am trying to add some supplements also and yours have been highly recommended.
    Regards,

    1. Hi Noche,

      Thank you for the comment and question.

      Ivermectin is not water-soluble, but is soluble in alcohol – this or taking it with fats may improve its absorption. In addition, Ivermectin seems to be affected by multi drug resistance pumps. When using it at the same time with multi drug resistance pump inhibitors, such as Verapamil, it seems its absorption is increased according to this study and related references https://parasitology.cvm.ncsu.edu/vmp930/supplement/ivermectin_pharmocology_rev2009.pdf

      This may be relevant:
      Successful treatment of recurrent follicular B-cell lymphoma with clarithromycin, prednisolone, and
      cyclophosphamide https://www.kjim.org/journal/view.php?doi=10.3904/kjim.2013.28.3.377
      Water-only fasting and an exclusively plant foods diet in the management of stage IIIa, low-grade follicular
      lymphoma https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4680557/
      Curcumin and EGCG Suppress Apurinic/Apyrimidinic Endonuclease 1 and Induce Complete Remission in B-cell Non-
      Hodgkin’s lymphoma Patients https://www.ffhdj.com/index.php/ffhd/article/view/108
      Remission of Follicular Lymphoma after Treatment for Hepatitis C Virus Infection https://www.
      researchgate.net/publication/309474393_Remission_of_Follicular_Lymphoma_after_Treatment_for_Hepatitis_C_
      Virus_Infection
      A case of follicular B-cell lymphoma treated using clarithromycin https://pubmed.ncbi.nlm.nih.gov/22065978/

      Thank you for the positive words on MCS Formulas and for considering that.

      Kind regards,
      Daniel

      1. Hi Daniel, in my quest for the use of IVM for cancer treatment, which one is the way to take, with fatty food (like Mebendazole/Fenbendazole) or on an empty stomach with only water. Thanks.Hi Daniel, in my quest for the use of IVM for cancer treatment, which one is the way to take, with fatty food (like Mebendazole/Fenbendazole) or on an empty stomach with only water. Thanks.

  11. Thank you Daniel for the quick reply. Unfortunately I am not able to understand some of the information I found in a couple of the links you posted. Especially because I am not willing at this point, to continue with chemo (it destroyed meafter 2 sessions) before I try metabolic treatment adding curcumin among a couple supplements plus Ivermectinand. Also very much interested in fasting for a long period of time. I really hope I am a good candidate. One thing I am not very clear is, with my Lymphoma, is 12mg. 5 days-2days off ok or maybe 10 days-20 days off ? And also, what is the best way to take it for better absorption? Thanks again.

  12. Hi Daniel, in my quest for the use of IVM for cancer treatment, which one is the way to take, with fatty food (like Mebendazole/Fenbendazole) or on an empty stomach with only water. Thanks.

  13. During Covid I sourced Ivermectin from “AllDayChemist” in India with no script .Took a few weeks. Since then have reordered IVM several times and also Menbendazole and many other things available like doxy and cholesterol drugs

      1. I’m not sure you still need this but it seems you Americans get ripped off a lot with meds,
        wail your herbal stuff is in so many cases a lot cheaper then in Europe.
        So, don’t you have family or friends in Europe ?
        I just checked the official pricing here in the Netherlands:
        Generic Meben 100 mg tablets, 2 a day = 0.91 eu /day !
        We here in Belgium can buy Vermox online ( Johnson& Johnson )( for human use ), OTC , 100 mg tablets for 6.77eu/6 tablets
        https://www .farmaline .be/apotheek/bestellen/vermox-100mg-6-tabletten/
        If your pharmacy does this price times hundred, imo that is a big rip off.
        And then there are these shops in India.

  14. Hello…
    I currently have multiple myeloma that is in very good partial remission since October 2021. I was stage 3 back in March 2021. I treated it , at first, with full RVD traditional treatment via Oncology, but combined it with Mistletoe to also flush the cancer out, strengthen my immune system and reduce side effects of the RVD. I stopped the harmful affects of the RVD when I reached VGPR in October 2021 and continued maintenance with subcutaneous mistletoe, helleborus and lien plumbum. I have held steady, but the protein light chains, though not dangerous, continue to show in my bloodwork and have mildly rise in the past 4 months. My homeopathic MD and I are looking for the final ingredient to purge my body of the disease. I have tried CLO2, and then Fenbenazole but they does not seem to affect my numbers in a positive way as we would like. Nest is IVERMECTIN.
    I am confused on the amount to take daily based on the recommended daily dosage for active, but not highly active cancer. Using the formula….
    a dose of 0.6 mg to 1 mg/kg/day,
    taken once a day (single dose),
    with food.
    What would be my daily dosage in mg? I weight 90kg or 200lbs. My homeopathic doctor thinks it would be 54 mg per day using that calculation above. It seems a bit much. Can anyone shed some helpful light here?
    Thank you very much.
    Jim Hurley

    1. Dear James,

      Thank you for your comment. First, I should say that nobody online is in the position to advise how much exactly one person should use, since there is so much about one person other than the little info we exchange in a few comments. What I try to generate with this website is a reference point on each relevant subjects to create science-based input for the discussion of the patient with his medical advisors.

      So, while I cannot advise how much you should use, in general, it makes sense not to extrapolate the dose as a function of weight forever, no matter what the wight is, and stop somewhere. On this line, I woudl consider the information from dr. Simon Yu where he seems to use 12 mg 3-4x/daily for 10 up to 30 days – it could be that this is what he is using in most of the cases as he did not mention a dose as a function of weight.

      As a side note, for blood cancers, Curcumin and EGCG stand out.

      I hope this helps.

      Kind regards,
      Daniel

      1. Thank you Daniel. My Homeopathic MD and I decided upon the scale as noted. I will be taking 54mg for 30 days. 5 days on and 2 days off. I have blood tests each month. At the end of September we will see and let you know. I will look into EGCG. I have been taking Curcumin for well over a year from a reliable and pure source I believe.
        God bless you.
        Shalom shalom
        Jim

        1. Hi Jim,

          You are very welcome. Regarding EGCG here is a case report in CLL that is relevant to understand the dose used https://www.cancertreatmentsresearch.com/community/leukemia/a-case-of-complete-and-durable-molecular-remission-of-chronic-lymphocytic-leukemia-following-treatment-with-epigallocatechin-3-gallate-an-extract-of-green-tea/#post-1141
          Just that at such a dose of EGCG the liver enzymes may increase, so that needs to be followed.
          Curcumin in blood cancers was also used in the range of several grams per day.

          God bless you too!
          Shalom shalom
          Kind regards,
          Daniel

  15. Hello Daniel,
    All I can say is WOW. Amazing article and the vast coverage was amazing.
    I have a question to tap your great knowledge.
    I have been diagnosed with bladder cancer .
    So far they went in and scraped what looked like coral in the ocean.
    Note: My wife is a Dr. so She has helped a lot with your extensive article.
    My Question is what would you recommend as a treatment for this. The Oncologist surgeon wants to insert a Chemo pill into my bladder as it has not metastasized to the wall of the bladder . My problem is I keep finding info about Ivermectin and omeprazole (which I have on hand) Could you give me a typical case where this was treated in this way I could read or hopefully you could suggest?
    I will anxiously look forward to your reply. Thank you again for the great article.
    Tyler & my wife Dr. Merryl

    1. Dear Tyler,

      Thank you so much for the kind feedback.

      Great to hear that you found it in a very early phase. Are they going to use Gemcitabine? If yes, indeed Omeprazole prior to that, as well as Hydroxychloroquine can help to reduce the chance of resistance and increase the effectiveness if Gencitabine. I do know patients in stage 4 who succeeded to cure blade cancer using this approach. If this subject is relevant to you, I will mention what kind of doses of Omeprazole and others have been used prior to and after chemo.

      There are indeed, many options that could be considered, from supplements known to be relevant against Cancer Stem Cells, such as Thymoquinone, Genistein to drugs such as Ivermectine and Nitroxoline relevant to balder cancer https://pdfs.semanticscholar.org/2cac/fa558aeefa51c41964d4b0d29e11d366f017.pdf

      Immune system activity is also more relevant in bladder cancer treatments https://www.news-medical.net/news/20210115/New-study-can-help-determine-effectiveness-of-chemotherapy-in-patients-with-bladder-cancer.aspx
      Coriolus is known to help activate T cells.

      In general, in such case, no matter if you are going to do use the chemo pill or not, I think it makes sense as you move forward, to consider cycles of drugs and supplements mentioned above, but also Artemisinin. I woudl also consider the use of Aspirin 100mg/day for some months to try to keep down inflammation, as well as Boswellia with high dose of AKBA that is a good support along the same line.

      Cimetidine (Tagamet) is also a very helpful drug that I woudl consider using it for several months after the intervention to reduce the chance for mets. In case this is used, I woudl keep in mind its potential to interact with other drugs.

      I am not aware of a specific report using Ivermectin for bladder cancer but I hope some of the info above helps.

      Kind regards,
      Daniel

  16. I am a caregiver to my wife 48 TNMBC brca2 Mets – she is currently on Targetted therapy parp inhibitor Olaparib. High possibility of brain/spine as she has neck pain and nausea that could be because of disease spreading or because of oral Olaparib. She recently came out of food poisoning and Covid however the nausea seems to continue, again not sure if long Covid or disease related. Would Ivermectin or any of the repurposed drugs be a good candidate, please advise. Thanks in advance

  17. RE: Ivermectin for prostate cancer.
    It seems impossible to find a source for a prescription for Ivermectin. I’ve been treating myself now for going on 7 years. On a recommendation from a friend I have been researching it’s use for prostate cancer specifically. My question may be rather fundamental: What specific product (horse, cow, dog, etc) of Ivermectin de-wormer would be the safest, purest form to use?
    Thank you!

    1. My wife has cancer and the medical establishment recently told me to seek out Hostel care… in other words go home to die. I have started her on Ivermection for horses, the brand is Duramectin , 1.87%. I did the calculations and a dose per weight is around 12-15 mg of Ivermectin. I take it with my wife and it has no side effects for us. I take it once a month to stop any Covid or paracites, she takes it twice a week. It is available at feed stores and on line at ‘Big R’ ranch stores.
      You can also buy the pills for human use on line, they are covert to stop the government from taking them down. The place is in North Carolina, the website is ivermection.com. The pills are about $2 per pill at 100 pills per bottle. I have also ordered some Fenbendazole to follow the Joe Tippins cancer protocal from a place in a Baltic state. I haven’t recieved these orders yet, so will find out if they are reliable soon. The company in Europe is Can Chema LTD. I can look up more info since I don’t have it with me. I looked at the site about Joe Tippins, “Joe Tippins beat cancer with $7 dog medicine”, a bottle cost $45.
      I hope this helps, I am struggling to keep my wife alive with scant help from the medical establishment. They will not write a prscription for these medicines, only the expensive Chemo is allowed.

    2. Merrill, I’m not sure where you reside, but I will share with you that I legally buy Ivermectin, Mebendazole, Metformin, OTC in Egypt. In the past few weeks I have been able to source iver as well as mebendazole. Last night I paid 108 EGP ($3.00) for 240 tablets of Mebendazole (tablets 100 mg). Iver is almost as impressive (24 tablets, 6 mg @ under $1.50). Depending upon where you live, a trip could be cost effective.

  18. Hello! My name is Elena, I am from Ukraine. I ask for help and tips. A friend has pancreatic tail cancer with metastases of omentum, diaphragm and peritoneal carcinomatosis. Due to the war in the country there are problems with good medications and there is a financial problem for the same reason. He was prescribed from what is available in the city cancer center such drugs – irinotecan, oxaliplatin, calcium folinate, 5-fluorouracil.
    The aggressive and rapid onset and progression of his disease occurred after two covid vaccines.
    What can be helped and what can be added from what is described in your blog? Given the vaccinations, is it better to choose ivermectin? We wanted to start with fenbendazole.
    I would be very grateful for your advice.
    Regards, Elena.

    1. Elena, I am very sorry to hear about your friend´s difficult situation and the ongoing war in your country.

      Here’s a study on the use of bicarbonate in pancreatic cancer:
      https://ar.iiarjournals.org/content/40/2/873
      Twenty-eight patients with metastatic or recurrent pancreatic cancer were assessed in this study. Alkalization therapy consisted of an alkaline diet with supplementary oral sodium bicarbonate (3.0-5.0 g/day). Results: The mean urine pH was significantly higher after the alkalization therapy (6.85±0.74 vs. 6.39±0.92; p7.0) was significantly longer than those with low urine pH (≤ 7.0) (16.1 vs. 4.7 months; p<0.05)

      Low-dose orlistat, ursolic acid, and/or guaraná may improve the effectiveness of oxaliplatin.
      Magnesium may reduce the effectiveness of oxaliplatin.

      Many supplements can help increase the effectiveness of 5-fluorouracil.

      Best regards,

      1. sorry, some of the text is missing:

        The median overall survival from the start of alkalization therapy of the patients with high urine pH (>7.0) was significantly longer than those with low urine pH (≤ 7.0) :16.1 vs. 4.7 months

    2. Oh my! That’s not good. Very sorry to hear. The vax absolutely impacts instead immune system. I know so many this has happened to. No immune system to fight cancer. I see some others have made suggestions. I’m going to suggest Chaga tea, bovine colostrum or better still other mushroom therapies to improve immune function (and no more vax). I agree about Fenbendazole. But also if you can get turmeric root powder, make turmeric paste to take orally. Spray body (or pour it on a cloth and wipe all over body) twice a day with 3% hydrogen peroxide. I also suggest Epsom salt baths every day once a day. Skin absorbs these things and they are very good for killing cancers and infections. If I think of more, I will reply again. I hope this helps.

  19. Hi Daniel,
    My husband had his 1st Immunotherapy infusion today (chemo-light?) for melanoma spread to the spine. We had been taking weekly Ivy to ward off the scary germ. We stopped 2 months ago, but have started back. I wonder if you have heard about any benefits with Melanoma. Thanks and God bless, Annie

    1. Dear Annie,

      Thank you for your comment. I am not sure what is the immunotherapy currently done, but if its anti-PD1 or PDL1, Ivermectin may very much make sense to be used at this time as it increases the chance for response https://journals.lww.com/oncology-times/Fulltext/2021/05050/Use_of_the_Anti_Parasitic_Drug_Ivermectin_to_Treat.4.aspx?WT.mc_id=HPxADx20100319xMP

      In addition, Ivermectin may prevent melanoma mets https://pubmed.ncbi.nlm.nih.gov/36132145/

      Kind regards and God bless,
      Daniel

  20. Dear Sir,
    May, 2022, my 67 yo husband was diagnosed with small cell lung cancer (four nodes in his right lung). Chemo and radiation followed for June and July. We followed, with our Oncologists knowledge, Joe Tippen’s protocol. Prior to this diagnosis, we also followed the FLCCC Alliance protocol for covid. No vaccines. I truly believe the Ivermectin we were taking as a virus prevention, slowed the aggressive cancer. August, 2022, my husband is cancer free!!. Not only is he taking 222mg of Fendendazole daily, he is taking 12mg of Ivermectin. Your publication is the first instance of recommended dosages that I happily happened upon.
    Hence, my question to you Dr. Daniel, is: what would you change in our follow up protocol as a cancer prevention? How much Ivermectin, how often and would you continue the Fendendazole as well and how much, how often.
    We also take Tumeric, Quercitin with zinc, D3 with k and recently added NAC. Do you see a problem with any of these supplements? He also has Omprezole as needed or perhaps daily. Also, pH balance has come to my attention. I purchased test strips and alkaline drops with electrolytes, especially potassium. My husband tested acidic, 5.5. Please correct me if I am wrong but it is my understanding that cancer loves an acidic environment. Therefore, I am administering drops to raise his bodies pH. Would this be the correct thing to do. I pull my hair out trying to make sure we are going in the right direction to prevent cancer reoccurring! Your input would be greatly appreciated as I am a layman in a medical experiment!
    Also, I obtain our Ivermectin, 12mg tablets from India Mart, a clearing house of sorts, using one company in particular. I purchased 1000, 12mg tablets for $100.00 plus $30 shipping fee plus the bank fee for money wire transfers. I am content with their product.
    Sincerely and gratefully,
    F. Collins

  21. My husband was just diagnosed with rectal cancer. He has a tumor at the bottom of the large intestine that has grown through the wall and now attached to the prostate. They have scheduled him for chemo (starting October 19)for 6 months, radiation & chemo for 6 weeks, and finally surgery. We are going to his family physician today to request ivermectin and praying this will start to shrink this tumor. Can you give me any advice?
    Can you give me the brand of ivermectin and the brand of fendendazole that your husband is taking? We are terrified of the chemotherapy and radiation. He is miserable now and for them to plan on these treatments before even attempting surgery, is crazy to me. Thank you, Karen

  22. Dear Karen,
    I ordered our Ivermectin from India and the package reads Iveractin, 12mg per tablet. I order our Fendendazole from Amazon.
    Panacur C , a 1 gram packet contains 222mg of Fenben. It saves money to buy 5 boxes containing 3 packets each for a months worth at a time, approximately $66. We followed Joe Tippen’s protocol (I recommend reading his blog first, mycancerrocks , as he tweaked the protocol slightly through the years.)
    Prior to my husband’s diagnosis, we had been taking supplements to boost our immune systems due to the pandemic. Ivermectin was part of that at a lower dose but I truly believe it slowed the progression prior to diagnosis. My husband will have another scan this month. I fully expect another, All Clear! He still takes a packet of Panacur C each morning and one 12mg Ivermectin (which if I am reading Dr. Daniel correctly, needs to be more.) We will switch to the prevention protocol later. I am still trying to decide if we can switch solely to Ivermectin and what dosage or incorporate both at some level. I am leaning toward using both. Dr. Daniel’s site has been helpful but I’m still concerned about the exact dosage. It can be a terrifying struggle to hopefully help rather than hinder a loved ones health. We are kind of flying by the seat of our pants and hope that we are doing the right thing. But, I truly believe that both drugs are safe and effective. Thus, our journey continues. I pass on our best wishes for you and yours as you try to navigate these waters as well. I hope this helps and am happy to be of service.
    F.Collins

  23. Hi Daniel,
    I am a 69 year old male of what was very good health. I have been diagnosed with Stage 4 adenocarcinoma….3 masses in my right lung. I started taking Ivermectin about 5 weeks 12mg, 2x a week, day 6 and day 3. I read the section about nebulizing the Ivermectin for direct application to lung cancer. I can certainly purchase a nebulizer…..how would I dissolve the Ivermectin, and how much, etc.
    Thank you so much for your invaluable research!!

    JIm Pearson

    1. I don’t think IVM should be be used in nebulizer. BUT you can nebulize 3%HP mixed with Colloidal or ionic silver. You can use food grade 3% hydrogen peroxide or even the regular stuff. I measure about ¼ to ⅓ of 3%HP into the container and fill rest of way with CS. Works great for resp infections. And it’s known that HP & CS both kill cancers! So I think that’s the safer thing to do while you take your IVM orally. Hope that helps!

  24. If anyone is looking for a reasonably-priced way to source ivermectin, you can search ‘noromectin’ on Amazon to find the 1% cattle injectable. I pull it out with a syringe to measure it (10 mg / mL) and then push it out into 2-3 empty gel capsules. That way I don’t have to taste it.

    I have stage IV TNBC. I’m on a clinical trial of combo immune checkpoint inhibitors (Texentriq + Tiragolumab). I was diagnosed April 2021 with mets to lung, bones, brain, and soft tissue. I’m currently NEAD (except some slow growth in my brain– unclear if it is radiation necrosis or cancer yet). I’ve taken various off labels and supplements; the most promising in my view have been Ivermectin, Tamoxifen, Miraviroc, Axitinib, pentoxifyllin, and low dose cyclophosphamide with methotrexate.

    I take ivermectin for the first two weeks or so after receiving my checkpoint inhibitors (four week cycle). I take 0.3-0.6 mg/kg.

    Good luck, everyone.

    1. I forgot to mention. At around 0.6 mg/kg I experienced some neurologic symptoms: feeling a bit ‘drunk’ and having some visual artifacts. This only happened the first few times. I still feel a bit fatigued at higher doses. In my view this is evidence it crosses the BBB.

  25. sorry that didn’t work. “johansays:
    MAY 28, 2022 AT 7:33 PM
    Of note, the relative safety of IVM use comes from the fact we don’t have any glutamate-gated ion channels outside of the brain and spinal cord, and only a low dose is taken just one time for its intended use. If and when IVM crosses the BBB, IVM will bind to the glutamate-gated ion channels in the brain! At the high continuous doses mentioned in this article, the safety profile of regular IVM use isn’t relevant IMO. For example, some dogs are genetically hypersensitive to ivermectin and it easily crosses the BBB and can be lethal to the animal.”

  26. Hello Doctor. I need some guidance in using ivermectin for my 80 year old father. In June 2022 he was diagnosed with lymphoma large b cell. He had 2sites one which was caused testicle cancer. The testicle was removed. He then started R-Chop. He had 4 doses which of course weakened him. We changed oncologist and then did one R mini chop. His CT scan is clear. I was wondering if he can take a regime for prophylaxis with ivermectin. Can you please recommend the dosage and protocol for cancer with ivermectin?

  27. I am curious on your thoughts on recent information that the C virus and injections may contain microscopic parasites. These parasites lodge in the body causing inflammation that may further result in cancer. This was one reason ivermectin was successful in covid cases, because it was reducing and or eliminating the parasites. There are several studies linking parasites, covid, cancer, and ivermectin.

  28. My husband was diagnosed with nasopharyngeal carcinoma in 2017. He underwent concurrent radiation and chemo with success. However, he suffered recurrence in 2018 and underwent more chemo. He has been clean until his last set of imaging. It has returned to the same area and in a lymph node. My question would be whether it would be beneficial for my husband to even take Ivermectin and, if so, could he take it orally, as well as possibly dilute it and use it as a nasal spray? Any help would be genuinely apprecaited.

    Thank you,

    1. Hi, and sorry to hear about the recurrence. Making a decision on which among the many alternative treatment options is not easy. You need to analyze the advantages and disadvantages as best as you can. IVM is generally well tolerated but serious neurological adverse events have been reported and should be supervised by a healthcare professional.

      1. Hi Johan, I am just looking for liquid IVM for inhalation through a nebulizer. Tell me why you shouldn’t inhale IVE and why you have this opinion?

        1. Hi Ropa, the relative safety of IVM use comes from the fact we don’t have any glutamate-gated ion channels outside of the brain and spinal cord, and only a low dose is taken just one time for its intended use. If and when IVM crosses the BBB, IVM will bind to the glutamate-gated ion channels in the brain! At the high continuous doses mentioned in this article, the safety profile of regular IVM use isn’t relevant IMO. For example, some dogs are genetically hypersensitive to ivermectin and it easily crosses the BBB and can be lethal to the animal.

          1. Тhere is mention of pediatricians, children took IVM 1mg/kg for a long time without any problems. True, the children do not weigh much and the dose was not large.
            But I don’t quite understand what this has to do with inhaling IVM into the lungs?

            p.s. The abbreviation BBB is Brain Barrier? and what is IMO?

            1. because it gets into the lung blood. Neurotoxicity from IVM is real.

              Also, you can damage your lungs if the dose is too high.

              In mice “lungs treated with ivermectin (0.2 mg/kg) revealed mild histopathological alterations, while severe pulmonary damage was seen in rats treated with ivermectin at doses of 0.4 and 0.8 mg/kg.”

              IMO= in my opinion

    2. This might be helpful. I use a nebulizer for anything respiratory. Cleared up both pneumonia and severe bronchitis wirh it. I use 3% hydrogen peroxide (many pharmacies & health food stores carry food grade as well as colloidal or ionic silver. you will need both). If you. Cant find food grade HP3%, you can use the regular HP3% that most stores sell. I fill the reservoir with about ¼ to ⅓ HP3% & rest of the way with the CS. 15 to 20 minutes with mask on twice a day. Reason im thinking this would be helpful is that HP kills cancer cells. I recently helped a friend cure a huge mast cell tumor on her dog…it was in a very bad spot so we couldn’t use turneric salve because there was no way to affix a bandage over the area. I had the idea that she should do Epsom salt compress 3 times a day or more and then spray liberally with 3% HP & CS but to give the salve orally (its just a very thick paste of organic turmeric root powder mixed into Liquid Sunflower lethicin which is nonGMO). This has worked spectacularly. The skin over the tumor tumor opened up and as the cells died, the dog debrided the dead tissues…so the tumor was expelled and right now the hole is granulating nicely and closing. I also told her to give Fenbendazole, but not sure if she actually did or not. I’ve cured cancers with turmeric salve MANY times. It also removes cysts as well. So I would suggest some kind of turmeric paste, or this salve orally as well. Just some thoughts for you. Good luck 🤞.

  29. My husband was diagnosed with esophageal cancer, T3,N1,Mx a month ago. We’ve never accepted the ‘burn/cut/poison’ methodology of western medicine, but circumstances have led him to have a port inserted & we’ll be hearing the recommendations / treatment plan of his oncology / radiology team before surgery. (Our homeopathic Practioner who tests with ElectroDermal Screening has him on numerous homeopathics, herbals & nutritional.). Can both IVM and Fenbendazole be taken during chemo & chemo/radiation to help shrink the cancer tumor?

  30. Hi.

    My mother has a carcinoma type breast cancer, very active. She tried Fenbendazole at 222mg a day, nothing helpful. She did not raise the dose for the 6 months she was taking it, so who knows if it may have helped or not.

    She wants to try next, Ivermectin and Mebendazole.

    Right now she is taking 12mg Ivermectin 5 days on / 2 days off. I think she needs to go higher in dose, she is 60 kg, so she’s taking .2mg per day. It’s been a week since she started.

    She wants to also add in Medbendazole. What schedule would you recommend? Keep to 5 days on / 2 days off for both? Or 5 days on for Mebendazole and then 2 days on for Ivermectin? Take them both daily?

    I looked over your article on Ivermectin and Oncology. Helpful, but not sure how to administer both Ivermectin and Mebendazole on a daily or weekly basis.

    I am not sure what a safe schedule is for her. She is also taking Metformin 200mg per day, which she needs to increase, I think, Naltrexone at night, a bunch of orther supplements, Curcumin, CBD oil, mushroom extract, IV Vitamin C once a week, a lot of stuff.

    I am trying to help her with contraindications or preventing adverse interactions with everything she’s taking, it’s difficult since I do not live in the same state as her.

    So do you have any recommendations on how to take Ivermectin and Mebendazole together?

    Anything information you can give me, would be so appreciated 🙏

    1. Hi, I am sorry to hear about your mother’s condition.

      If Fenbendazole didn’t help, I doubt Mebendazole will.

      I think the amount of Ivermectin she is taking is adequate. I’ve heard Ivermectin and Vitamin D in combination are quite effective. 2000IU of Vitamin D3 a day.

      There are a lot of other options to add as adjuvant treatment, try to see what works and what does not.

      Is she taking Tamoxifen?

      Inositol hexaphosphate (IP6) enhances the anti-proliferative effects of adriamycin and tamoxifen in breast cancer:
      https://pubmed.ncbi.nlm.nih.gov/12846414/

      Best wishes

  31. Hello Daniel
    I am new to this site
    I have had colorectal cancer since 2018
    Had radiation
    Oral chemo
    Surgery
    Now they are looking at immunotherapy
    I am very interested in this article

    All this information is quite overwhelming but from my limited ready and understanding I am very interested in ivermectin
    My problem is I am in Australia yep and getting ivermectin and dr to agree is hard
    Do you know of anyone over here that might be able to see me or help please
    Been a long journey
    I am on various vitamins and take bicarbonate Soda daily watching my ph levels

    Thank you 🙏🏽

  32. Merrill, I’m not sure where you reside, but I will share with you that I legally buy Ivermectin, Mebendazole, Metformin, OTC in Egypt. In the past few weeks I have been able to source iver as well as mebendazole. Last night I paid 108 EGP ($3.00) for 240 tablets of Mebendazole (tablets 100 mg). Iver is almost as impressive (24 tablets, 6 mg @ under $1.50). Depending upon where you live, a trip could be cost effective.

      1. Hello Ropa, It’s not in a “state pharmacy” – closer to a little stall. I’m praying that the quality is OK because it’s what I have access to. Fenben is not available anywhere here – but through a vet pharmacy I did find an acceptable substitute (I hope!).

        1. Hello Mary B.M., didn’t see your reply, got a couple questions. I sent you a contact request on linkedin.in, please check it out. Can you communicate there?

  33. Dear Daniel
    Just came across your website. My 72 year old husband has been diagnosed with colorectal cancer with mets to the liver, lungs and peritoneal cavity. He is due to see an oncologist on 26th June 2023 but as he is relatively comfortable, he is reluctant to try chemo etc and without, the outlook is quite bleak according to the Consultant at the hospital. We are speaking with an oncologist nurse from Healing Navigator on Monday 19 June about starting treatment with Fenbendazole. People have also suggested that he combine this with Ivermectin. He really struggles to take tablets and the Fenbendazole is also combined with supplements which will be difficult enough. I have read that you can apply Ivermectin to the sole of the foot. I do have some of the 1.87% paste which I bought to treat myself regarding parasites. If I applied this to his foot, would it at least be of some benefit to him. I am desperate to help him and am literally screaming inside. We will be married 30 years in September. I know Fenbendazole and Ivermectin have had amazing results and at this point, we have nothing to lose. Your advice is very much appreciated.

    1. Dear Dee,

      I am so sorry to hear about having to go through these challenges, and I hope from now your dear husband will only improve regarding this health challenge so that you can celebrate 40 and 50 years wedding anniversary.
      If your dear husband cannot take tablets, in my view the supplements recommended next to Fenbendazole are not key, and they can be skipped. Also, I think that in case of colorectal c. Mebendazole may be even more promising. Furthermore, if tablets or caps cannot be used, I woudl consider options such as Silver solution https://www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/?highlight=silver

      I wish you and your dear husband a lot of good health!

      Kind regards,
      Daniel

  34. Buna ziua Daniel. Eu am avut un carcinom scuamos de rinofaringe radio chimio tratat , acum am recidiva la sinusul cavernos cu extensie catre nervii cranieni si ureche. In prezent fac imuno cu Opdivo dsr as vrea sa iincep sa iau Ivermectina , dar din pacate nu reusesc inca sa inteleg doza pe care ar trebui sa o iau. Mentionez ca tumora este in remisie acum dar as vrea sa ma asigur ca pot face ceva mai mult pt asta . Eu am 65 kg si fac imuno cu opdivo de 240 mg o data la 2 sapt. Te rog frumos ma poti ajuta mai clar ch dozarea ? cate zile pe luna on si cate off ? si cate mg pe zi ? Ii multumesc. Cu stima si respect !

  35. Hello Daniel ,
    my 75 year old father was diagnosed a year and a half ago with colon cancer . he got surgery but at the following check-up they descovered cancer cells in multiple places … 2 in the liver ,one in the illiac crest and one in his shoulder. he tried chemo once but was not his path . For a half a year he had removed totally sugar from his diet and started using CBD oil 30% 3 times per day , and once a week octave resonance and rapid image cycling … his general state improved but recently he broke his shoulder and the moral went downhill … he would like to try ivermectin treatment, but in Romania no doctor would prescribe it …. it is easy to buy it at the vet and quite cheap , what would be a minimum dosage to start and what cycle he should follow ?
    thank you in advance and hopefully this would bring some hope in my fathers future
    kind regards Kimsy .

    1. Hi Kimsy,
      in the following study in mice, they used 2mg/kg injected i.p. which is a human equivalent dose of approx 10mg for a 60kg person or 12mg for a 75kg person.
      https://jeccr.biomedcentral.com/articles/10.1186/s13046-019-1251-7

      At that dose, IVM in combination with vincristine had a stronger anticancer effect compared to vincristine alone. Ivermectin alone was less effective than vincristine and on par with control (meaning no noticeable anticancer effect).

  36. Hallo,
    can ivermectin be taken with fenbendazole on the same day. How long should they be separated for? For example, Fenben in the morning or at 12h and IVE at 18h or vice versa ?

  37. My husband has stage 4 esophageal cancer, metastasized to his brain. When first diagnosed in February, surgery was done to remove mass in the brain but we were told tumor in esophagus (low, above the stomach) was inoperable. He has never had any pain at all or trouble swallowing. He had a bad seizure about 2 weeks ago, back to the hospital, no treatment but anti seizure drug and anti swelling drug, and they sent him home with hospice. He wants to try Ivermectin. We have some 12 mg tablets. He is 77 years old and weighs 175 lbs. What would be the recommended dose? Integrative oncologists are few and far between where we live in AZ. Thank you for all your research and all these comments!

  38. Hello Daniel ,
    my father had colon cancer surgery 2 years ago ,after that there were still multiple points in his body ,it went ok after untill june this year when he broke his arm . he is not feeling very well since then but he still goes on with the no sugar ,cbd oil and now he is in the break between cycle 2 and 3 of ivermectine.
    since he started with ivermectin he keept feeling a sort of lump growing somehow on top of his liver …. my question is can it be a reaction to ivermectine ? like a fast tumor or increased liver ?
    thank you in advance

  39. Buna ziua,

    Tatal meu are diagnostic de cancer renal cu metastaza la os.
    Pentru acesta ia sutent de 50 mg/ zi – 14 zile si 7 pauza si sol. injectabila Xgeva, una pe luna.
    A inceput sa ia ivermectina cate 9 mg si apoi a crescut doza la 18 mg/ zi, problema este ca atunci cand ia pastilele de ivermectina are cate 2,3 scaune diareice.
    Va rog sa mi spuneti daca este normal. Noi pe acest motiv nu stim daca sa continuam cu ivermectina sau nu.

    Multumesc mult!

  40. Ivermectin as an inhibitor of cancer stem cells has a high structural similarity with salinomycin.
    https://pubmed.ncbi.nlm.nih.gov/29257278
    “Compounds identified in DrugBank possessed a low molecular similarity with salinomycin. Subsequent results from the similarity searching using salinomycin as a query molecule identified 25 top-ranked compounds with a high similarity value. To define a compound with ‘high’ similarity value, molecules were selected as those with similarity values two standard deviations above the mean similarity of all DrugBank compounds to salinomycin. Ivermectin had the highest similarity value of 0.78, and following the principle of molecular similarity, which states that similar compounds demonstrate similar properties, it was hypothesized that the antiparasitic drug ivermectin may also possess similar biological properties as salinomycin.”

    Ivermectin converts cold tumors hot and synergizes with immune checkpoint blockade.
    https://pubmed.ncbi.nlm.nih.gov/33654071

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