An Anti-Cancer Compound Hiding in Front of Us: Gluconate

Gluconate, a cheap, available and harmless substance I recently came across this scientific article reference by one of the active members of this website (J) and realised that something very valuable was hidden in there. In this article, the authors are discussing Gluconate.  Their research suggests that the anti cancer effect of Gluconate could be relevant
Continue reading An Anti-Cancer Compound Hiding in Front of Us: Gluconate

Making Cholesterol-Lowering Statin Drugs More Effective Against Cancer

Statins and Cancer Dear Friends, I am currently on holiday, travelling and with little access to the computer, but recently I came across interesting information related to the use of Statins to fight cancer, and would like to share that with you as soon as possible. So I decided to allocate a day and consolidate
Continue reading Making Cholesterol-Lowering Statin Drugs More Effective Against Cancer

Anti Cholesterol Strategy to Fight Cancer

Background So far I wrote several posts that are in a way or another related to cholesterol & cancer, underlying the role of Cholesterol in cancer. More specifically, we have seen that drugs or supplements that reduce or inhibit the absorption, use and/or production of cholesterol in cancer cells, have also the potential to kill cancer cells: Ref. Indeed,
Continue reading Anti Cholesterol Strategy to Fight Cancer

Bisphosphonates: Against Skeletal Lesions + Direct Anti-Tumor Action

Background: Many cancers either metastasize to the skeleton or grow primarily within the bone marrow, where this growth frequently leads to hypercalcemia, severe bone pain, skeletal destruction, and pathologic fractures. Indeed, the skeleton is the most common site of metastatic disease, and some of the patients with advanced cancer may develop skeletal lesions (Ref.). Bisphosphonates (BPs)
Continue reading Bisphosphonates: Against Skeletal Lesions + Direct Anti-Tumor Action

Itraconazole: An Antifungal Drug With Anti Cancer Properties

Background: Itraconazole is a FDA approved drug, developed as an orally administrated antifungal drug, and has been used clinically for many decades with a well-established safety record. It has been used in the prevention and treatment of a broad range of fungal infections, such as aspergillosis, blastomycosis, candidiasis, histoplasmosis, but also in various dermatological and nail infections. Since
Continue reading Itraconazole: An Antifungal Drug With Anti Cancer Properties

Cholesterol & Cancer: Inhibit ACAT to Kill Aggressive Cancers

Summary: Cholesterol is a lipid molecule present in the membranes of all mammalian cells and is essential for their growth and viability. As an indispensable constituent of plasma membranes, cholesterol affects properties and functions of membrane proteins such as receptors, enzymes, or ion channels. Cells produce cholesterol or are able to draw it from extracellular sources via
Continue reading Cholesterol & Cancer: Inhibit ACAT to Kill Aggressive Cancers

Another weak spot of cancer cells: ATP citrate lyase inhibition

ATP citrate lyase is an important enzyme for he fast dividing cancer cells ATP citrate lyase (ACL or ACLY) is an intracellular enzyme (located in cytosol) responsible for the conversion of citrate that comes out of the mitochondria,  to acetyl-CoA and oxaloacetate. ATP citrate lyase is primarily expressed in lipogenic tissues. Other vegetative tissues express little to
Continue reading Another weak spot of cancer cells: ATP citrate lyase inhibition