Anti Cholesterol Strategy to Fight Cancer

Background So far I wrote several posts that are in a way or another related to cholesterol & cancer, underlying the role of Cholesterol in cancer. More specifically, we have seen that drugs or supplements that reduce or inhibit the use or production of cholesterol in cancer cells, have also the potential to kill cancer cells: Ref. Indeed, there
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Bisphosphonates: Against Skeletal Lesions + Direct Anti-Tumor Action

Background: Many cancers either metastasize to the skeleton or grow primarily within the bone marrow, where this growth frequently leads to hypercalcemia, severe bone pain, skeletal destruction, and pathologic fractures. Indeed, the skeleton is the most common site of metastatic disease, and some of the patients with advanced cancer may develop skeletal lesions (Ref.). Bisphosphonates (BPs)
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Itraconazole: An Antifungal Drug With Anti Cancer Properties

Background: Itraconazole is a FDA approved drug, developed as an orally administrated antifungal drug, and has been used clinically for many decades with a well-established safety record. It has been used in the prevention and treatment of a broad range of fungal infections, such as aspergillosis, blastomycosis, candidiasis, histoplasmosis, but also in various dermatological and nail infections. Since
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Cholesterol & Cancer: Inhibit ACAT to Kill Aggressive Cancers

Summary: Cholesterol is a lipid molecule present in the membranes of all mammalian cells and is essential for their growth and viability. As an indispensable constituent of plasma membranes, cholesterol affects properties and functions of membrane proteins such as receptors, enzymes, or ion channels. Cells produce cholesterol or are able to draw it from extracellular sources via
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Another weak spot of cancer cells: ATP citrate lyase inhibition

ATP citrate lyase is an important enzyme for he fast dividing cancer cells ATP citrate lyase (ACL or ACLY) is an intracellular enzyme (located in cytosol) responsible for the conversion of citrate that comes out of the mitochondria,  to acetyl-CoA and oxaloacetate. ATP citrate lyase is primarily expressed in lipogenic tissues. Other vegetative tissues express little to
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