Thalidomide: From Medical Disaster to Miraculous Cancer Treatment

Background: In 1957, Thalidomide was an over the counter drug used by pregnant women in West Germany, against morning sickness and nausea. Thalidomide, was hailed as a wonder drug that provided a safe, sound sleep. Unfortunately the complete spectrum of Thalidomide’s action were not well understood at that time, and shortly after the drug was brought to the
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Omega-3 Fatty Acids, Budwig Diet & their Antitumor Activity

Summary: This is a long post so here is a short summary: Omega-3 fatty acids have anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. Because Omega-3 fatty acids are pushing out of the cancer cells the glutathione much needed for the cancer cell survival, Omega-3 fatty acids can be also combined with chemo and with that increase or enable chemo
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Creatine: Counteracts Cachexia and Supports Methylglyoxal

Background: Creatine  is a nitrogenous organic acid that occurs naturally in vertebrates and helps to supply energy to all cells in the body, primarily muscle. It is produced in the human body from the amino acids glycine and arginine. Creatine supplements are widely used by athletes, bodybuilders, wrestlers, sprinters, and others who wish to gain muscle mass,
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Glutamine Supplementation

Intro on Glutamine Glutamine is the most abundant, naturally occurring, non-essential amino acid in the human body. It is synthesized through enzymatic action of glutamine synthetase (GS) that combines glutamate and ammonia. It is synthesized through enzymatic action of glutamine synthetase (GS) that combines glutamate and ammonia. It serves as a vehicle for transporting ammonia in a nontoxic
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Potential solutions against Cachexia: Glutaminolysis inhibitors and more

Conclusion To avoid cachexia we need to reduce the request for glutamine via lactate (see the seven points below) and in order to kill cancer cells relying on glutamine we should reduce/inhibit glutaminolysis (e.g. EGCG), reduce glutamine transport (retinoic acid), reduce blood glutamine (phenylbutyrate and avoid (red) meet). Background Cachexia is loss of weight, muscle
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