Mebendazole: A Cancer Fighting Drug We Find at the Supermarket

Background: Yes, in the European countries Mebendazole can be found on the supermarket shelves. Mebendazole is an anthelmintic drug that has been used since the early 1970s to treat a range of parasitical worm infections, including threadworm, tapeworms, roundworms, and other nematode and trematode infections in humans and domestic animals (Ref.). The drug is among those on the World
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Anti Cholesterol Strategy to Fight Cancer

Background So far I wrote several posts that are in a way or another related to cholesterol & cancer, underlying the role of Cholesterol in cancer. More specifically, we have seen that drugs or supplements that reduce or inhibit the use or production of cholesterol in cancer cells, have also the potential to kill cancer cells: Ref. Indeed, there
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Taurolidine: A Disinfectant & Inhibitor of Tumor Growth

Background: Taurolidine is a molecule that comprises Taurine (the most abundant free amino acid in the heart, retina, skeletal muscle, brain, and leukocytes). It was first produced in the 1970s by Geistlich-Pharma Inc, designed as a broad-spectrum antibiotic and used in the local treatment of peritonitis. (Ref.) It is effective against both aerobic and anaerobic bacteria. (Ref.) Due to
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Thalidomide: From Medical Disaster to Miraculous Cancer Treatment

Background: In 1957, Thalidomide was an over the counter drug used by pregnant women in West Germany, against morning sickness and nausea. Thalidomide, was hailed as a wonder drug that provided a safe, sound sleep. Unfortunately the complete spectrum of Thalidomide’s action were not well understood at that time, and shortly after the drug was brought to the
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Serotonin Makes Tumors Happy Too

Serotonin and its Role: Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system of humans. Serotonin is manufactured in the brain (dorsal raphe nucleus cells, which are located deep in the brain) and the intestines and is primarily stored in and transported by
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Itraconazole: An Antifungal Drug With Anti Cancer Properties

Background: Itraconazole is a FDA approved drug, developed as an orally administrated antifungal drug, and has been used clinically for many decades with a well-established safety record. It has been used in the prevention and treatment of a broad range of fungal infections, such as aspergillosis, blastomycosis, candidiasis, histoplasmosis, but also in various dermatological and nail infections. Since
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Maraviroc: An anti-HIV Drug that Reactivates the Immune System to Fight Cancer

Introduction: Recently, with the help of a reader of this website (Thank you, Jose!), I came across a very relevant article, Immunotherapy in metastatic colorectal cancer for the first time utilizes the innate immune system, published on the website of the German Cancer Consortium (DKTK). This article describes the results of a recent clinical trial running in Heidelberg, Germany using an
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Omega-3 Fatty Acids, Budwig Diet & their Antitumor Activity

Summary: This is a long post so here is a short summary: Omega-3 fatty acids have anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. Because Omega-3 fatty acids are pushing out of the cancer cells the glutathione much needed for the cancer cell survival, Omega-3 fatty acids can be also combined with chemo and with that increase or enable chemo
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Citric Acid Inhibits Fermentation and Kills Cancer in Humans

Background:  Citric acid exists in large amounts in a variety of fruits and vegetables, most notably citrus fruits and was first time isolated from lemon juice.  Its salt form, Citrate, is an intermediate in the citric acid cycle (also called TCA cycle, TriCarboxylic Acid cycle, Krebs cycle, Szent-Györgyi – Krebs cycle), a central metabolic pathway for animals, plants and
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High Dose Vitamin C & Cancer

Background: L-ascorbic acid (C6H8O6), known as Vitamin C, has a variety of functions in humans, some of which are not yet fully understood. It was discovered in 1930 by Albert Szent-Györgyi (Hungarian, half Romanian by descent), who as a result of this discovery received  Nobel Prize in Physiology or Medicine in 1937. Note, that Albert Szent-Györgyi is the same scientist
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Hyaluronic Acid Modulation: Preventing Recurrence or Supporting Other Therapies – Otherwise Better Not

Recently, I was reading this article Why cancer drugs can’t take the pressure, arguing that “A major reason why cancer drugs fail is that they cannot penetrate the high-pressure environment of solid tumors.” and that the reason for that is a “naturally occurring molecule called hyaluronic acid, primarily responsible for generating elevated gel-fluid pressures in tumors.”
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Propranolol: A “Heart Drug” that Stops Cancer Progression due to Stress

Background: Propranolol is a drug commonly used to treat high blood pressure, irregular heart rhythms, pheochromocytoma (tumor on a small gland near the kidneys), certain types of tremor, and hypertrophic subaortic stenosis (a heart muscle disease). It is also used to prevent angina (chest pain), migraine headaches, and to improve survival after a heart attack.
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Heparin: Great Value in Cancer Treatment

Background: Heparin is a widely used injectable blood thinner. It is typically administrated as an injection IP (anyone can do it at home) or Intra Venous. It is used to treat and prevent deep vein thrombosis and pulmonary embolism (collectively known as venous thromboembolism). According to Wikipedia, Heparin’s normal role in the body is unclear. Heparin
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Visitor Comment: Remission after starting TM (Tetrathiomolybdate)

Today, I received a new comment on an article I wrote sometimes ago on Tetrathiomolybdate: http://www.cancertreatmentsresearch.com/?p=249 I find the comment so relevant that I am going to publish it here, to increase its visibility: My girlfriend started taking TM in late 2001 after her oncologist threatened to cut her off if she didn’t have mastectomies and a hysterectomy. She had
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A Natural Painkiller and Anti-Inflammatory: Palmitoylethanolamide (PEA)

Summary: PEA is a body-own fatty compound, and is produced by our own living cells to restore balance in chronic pain and chronic inflammation. Its anti-inflammatory and painkilling properties are known in science many decades since the first description of this compound in 1957. in 1993 the Nobel price winner professor Rita Levi-Montalcini pointed out
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Treating Ascites with Angiogenesis Inhibitors

Malignant ascites are side effects of some cancers (and potentially anti-cancer treatments), characterized by the accumulation of fluid in the abdomen. Recently, I have received from a friend this article on ascites (from epithelial ovarian cancer), and thought is a good idea to share this here: Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in
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Diflunisal

CAS 22494-42-4 My opinion: An anti-cancer treatment with great potential relevant for most types of cancers visible on PET/CT. Regarding its effectiveness, this statements says it all: “33 patients were evaluable for metric response, 20 for metabolic and 19 for tumor marker response assessment. For tumor marker follow up 11 % had a CR, 53 %
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Plerixafor (Mozobil)

My opinion: Plerixafor works against the part of immune system (M2–macrophages) that helps the tumor to regrow after an effective treatment has succeeded to kill part of it. Therefore, Plerixafor is a great supportive treatment for any effective anti cancer strategy including surgery, chemo and radiotherapy. We do not have any experience with it. Summary & Mechanism The immune system plays a major
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