Hi friends, just sharing the following:

https://www.eurekalert.org/pub_releases/2021-02/rpi-gtc021021.php

Green tea compound aids tumor-suppressing, DNA-repairing protein

NEWS RELEASE: 12 FEB 2021

Research offers new lead for cancer drug discovery

RENSSELAER POLYTECHNIC INSTITUTE

An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the "guardian of the genome" for its ability to repair DNA damage or destroy cancerous cells.

Published today in Nature Communications, a study of the direct interaction between p53 and the green tea compound, epigallocatechin gallate (EGCG), points to a new target for cancer drug discovery.

"Both p53 and EGCG molecules are extremely interesting.

Mutations in p53 are found in over 50% of human cancer, while EGCG is the major anti-oxidant in green tea, a popular beverage worldwide," said Chunyu Wang, corresponding author and a professor of biological sciences at Rensselaer Polytechnic Institute.

"Now we find that there is a previously unknown, direct interaction between the two, which points to a new path for developing anti-cancer drugs.

Our work helps to explain how EGCG is able to boost p53's anti-cancer activity, opening the door to developing drugs with EGCG-like compounds."

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https://www.nature.com/articles/s41467-021-21258-5

EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

Published: 12 February 2021

Thanks.

Kimster