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Green Tea EGCG --- Boost p53's Anti-Cancer Activity


Kimster
(@kimster)
Joined: 1 year ago
Posts: 109
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Hi friends, just sharing the following:

 

https://www.eurekalert.org/pub_releases/2021-02/rpi-gtc021021.php

Green tea compound aids tumor-suppressing, DNA-repairing protein

NEWS RELEASE: 12 FEB 2021

Research offers new lead for cancer drug discovery

RENSSELAER POLYTECHNIC INSTITUTE

 

An antioxidant found in green tea may increase levels of p53, a natural anti-cancer protein, known as the "guardian of the genome" for its ability to repair DNA damage or destroy cancerous cells.

Published today in Nature Communications, a study of the direct interaction between p53 and the green tea compound, epigallocatechin gallate (EGCG), points to a new target for cancer drug discovery.

"Both p53 and EGCG molecules are extremely interesting.

Mutations in p53 are found in over 50% of human cancer, while EGCG is the major anti-oxidant in green tea, a popular beverage worldwide," said Chunyu Wang, corresponding author and a professor of biological sciences at Rensselaer Polytechnic Institute.

"Now we find that there is a previously unknown, direct interaction between the two, which points to a new path for developing anti-cancer drugs.

Our work helps to explain how EGCG is able to boost p53's anti-cancer activity, opening the door to developing drugs with EGCG-like compounds."

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https://www.nature.com/articles/s41467-021-21258-5

EGCG binds intrinsically disordered N-terminal domain of p53 and disrupts p53-MDM2 interaction

Published: 12 February 2021

 

Thanks.

Kimster

This topic was modified 2 weeks ago by Daniel

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Daniel
(@daniel)
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Joined: 6 years ago
Posts: 981
 

Dear Kimster,

 

Thank you so much for the heads up on this very recent paper. It's so nice to see yet another high impact publication (Nature Communication) supporting the outstanding role of EGCG. This is why EGCG is on top of our list.

Also thank you so much for thinking to help and adding the link to MCS Formulas EGCG product. In order to stay in line with regulations and with ethical aspects, I felt responsible to remove the direct link to the product. I apologize for that, and thank you so much for your kindness trying to help which is very much appreciated.

Have a very nice weekend!

Kind regards,
Daniel


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Kimster
(@kimster)
Joined: 1 year ago
Posts: 109
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@daniel

 

Hi Daniel, thank you for your reply to this post - noted & well understood 🙂

 

Thanks again 🙂

Kimster


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