Dear Kimster,

IP6 was not discussed here. It is one of those outstanding from a scientific point of view, but I was not aware of the case report. Such results clearly puts IP6 in the category of some of the most relevant supplements as we now not only have the science but also facts to support positive expectations.

This report also indicates again that high dose of a specific supplement has to be used in order to be able to expect effectiveness.

Thank you so much for adding this here! What a great contribution! 

Kind regards,
Daniel

Posted by: @kimster

Dear Friends in this website,

Hi, I'm creating this "Phytic Acid" topic as noticed its benefits --- but it seems that "Phytic Acid" has not been discussed in this website if not mistaken.

https://mayoclinic.pure.elsevier.com/en/publications/inositol-hexaphosphate-plus-inositol-induced-complete-remission-i
Inositol hexaphosphate plus inositol induced complete remission in stage IV melanoma: a case report

 

Thanks.
Kimster

Hi Kimster, great find! IP6 is one of my favorite supplements and easily added to our diets by eating plenty of beans. 

Here's a great video, very motivational, by Dr. Joel Fuhrman MD

https://www.youtube.com/watch?v=76XklHNzWx0&feature=emb_title

I started eating beans after reading his books, and videos by Dr. Michael Greger MD.

It's now my favorite food and eat beans at least once a day.

Glad you brought this up!

@daniel

Dear Daniel,

Hi, thank you very much for your reply to this topic --- as I was not sure whether friends/visitors in this website would notice this topic or not.

I also just realised there were such a case report when I was reading the information from this website:
https://thesoynutritioninstitute.com/soy-high-phytate-foods-may-help-prevent-cancer/

Much of the work involving the role of phytate in reducing risk of cancer of all types has been conducted by Dr. AbulKalam M. Shamsuddin and colleagues from the University of Maryland School of Medicine.
They postulate that the anticancer potential of phytate is due to a combination of antioxidant, anti-inflammatory, and immune-enhancing activities.
Inositol and IP6 may work together additively or even synergistically.
Nevertheless, despite a fair amount of promising research, it is fair to say the anti-cancer properties of phytate haven’t received a lot of attention over the years.

That is one reason this conclusion by Khurana and colleagues caught my attention: “Although this is a single clinical case showing IP6 + inositol’s potential role in controlling our patient’s stage IV disease and spontaneous regression of primary melanoma, and rarely metastatic melanoma has been reported in literature, we believe that there are ample preclinical and clinical data to suggest that this nontoxic, readily available supplement should be evaluated in clinical trials for its antitumor activity.”

The patient in question had metastatic melanoma but declined traditional therapy and opted instead to try an over the counter supplement of IP6 + inositol.
The patient achieved a complete remission and remains in remission 3 years later.
The patient took daily 4,000 mg of phytate and 1,100 mg of inositol.

------------------------------------

Hopefully in the future, Daniel would create a "main" article to introduce this IP6 when there is more information to be shared with friends/visitors in this website --- as not sure whether this topic created in the forum would be noticed by many friends/visitors of this website.

Would MCS Formulas consider selling this "nontoxic, readily available" IP6 supplement in the future?

- as this IP6, as natural antioxidant, seems to have other benefits as explained in this:

https://onlinelibrary.wiley.com/doi/full/10.1111/1750-3841.13320
Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems

Thanks.
Kimster

@johan

Hi, thank you very much for your reply & sharing your experience & the video.

I also read the book, "How Not to Die", by Dr. Michael Greger.

I noticed the following information:

https://www.precisionnutrition.com/all-about-phytates-phytic-acid
Phytate digestion
Most phytate (37-66%) is degraded in the stomach and small intestines.
Ordinarily, our bodies regulate phytate levels pretty well, adjusting uptake in the gut and excretion until body levels come into balance.
Vitamin D status in the body seems to influence how much phytate is actually retained. 
The more vitamin D, the more phytate retained; the less vitamin D, the less phytate retained.

http://www.phytojournal.com/archives/?year=2017&vol=6&issue=6&ArticleId=2263&si=false
A review phytic acid: As antinutrient or nutraceutical

Food sources of phytic acid
The most concentrated sources tend to be oil seeds, whole grains and legumes.
Phytic acid is isolated in the aleurone layer in most grains, making it more concentrated in the bran. In legumes, it’s found in the cotyledon layer.
Table 1. Shows different concentrated sources of phytic acid (% dry wt.)

https://www.westonaprice.org/health-topics/vegetarianism-and-plant-foods/living-with-phytic-acid/
Living With Phytic Acid

FIGURE 1: FOOD SOURCES OF PHYTIC ACID
As a percentage of dry weight

FIGURE 2: PHYTIC ACID LEVELS
In milligrams per 100 grams of dry weight

FIGURE 4: PHYTATE
As Percentage of Dry Weight

Thanks.
Kimster

Posted by: @kimster

Vitamin D status in the body seems to influence how much phytate is actually retained. 
The more vitamin D, the more phytate retained; the less vitamin D, the less phytate retained.

 

I always learn something new when you post, thanks for sharing.

Posted by: @kimster

16 Health Benefits of Phytic Acid: The “Anti-Nutrient”

Posted by: @johan

I started eating beans after reading his books, and videos by Dr. Michael Greger MD.

It's now my favorite food and eat beans at least once a day.

Wow! They always recommend soaking the legumes, seeds and nuts and cooking beans for a long time to get rid of phitates and other anti-nutrients. Was this bad advice? What would be a good practice in the context of these findings?

@gge

Hi, I noticed some information from this website:

https://breakingmuscle.com/healthy-eating/dissecting-anti-nutrients-the-good-and-bad-of-phytic-acid

Finding a Solution

Now here’s the catch. The potential benefits of phytic acid occur in instances with high dietary phytic acid intake. However, a high intake has also been associated with reduced mineral absorption. So, in order for us to get the best of both worlds (if such a thing is possible) it’s important to discover some ways in which we can minimize the negative effects while maximizing the beneficial effects.

One way we can do this (specifically in regards to iron) is by incorporating more vitamin C (ascorbic acid) into our diet. These two work well together, with vitamin C placing iron in a chemical state that is more readily absorbed by the body.¹⁴

Preparation methods such as soaking, germinating, or fermenting can be very effective in reducing the amount phytic acid present in foods. Some methods are better for different foods. In the case of nuts and legumes, soaking and germinating are most successful, but for grains and cereals, all three are effective.

Another way to maximize benefit of phytic acid is to simply increase the consumption of foods rich in iron, zinc, magnesium, and calcium that are naturally low in phytic acid. For example, consider eating more animal-based proteins. Understandably, this can be challenging for vegetarians and vegans and may warrant the inclusion of a vitamin and mineral supplement.

One last strategy is to focus more on meal timing. In other words, eat foods that contain phytic acid separately from foods that are richer in minerals. From a practical standpoint, one could accomplish this by eating meals of protein and fat separate from meals of carbohydrate and fat.

Thanks.

Kimster

@gge

If you´re not used to the phitates there's an adaptation period. The "anti-nutrient" issues seem to occur only in this adaptation fase. I soak the beans overnight, and also use canned beans, it's convenient. 

@johan

Hi, I also learnt from your information shared in this website 🙂

Thanks a lot for sharing the video by Dr. Joel Fuhrman MD --- after viewing it, then I visited his website to learn more information.

Please continue to share information 🙂

Thanks.

Kimster

Posted by: @kimster

Preparation methods such as soaking, germinating, or fermenting can be very effective in reducing the amount phytic acid present in foods. 

If you are fighting cancer, wouldn’t you want to raise your Phytate intake to get to a state of remission like the stage IV melanoma patient? Why would you want to reduce the phytate in your food, which is potent than the phytate from supplements?

Also, how best to reduce lectin and the other anti-nutrients without losing the phytate?

Posted by: @kimster

I'm creating this "Phytic Acid" topic as noticed its benefits

Kim, this supplement is very interesting. Thanks for bringing it up!

https://www.mskcc.org/cancer-care/integrative-medicine/herbs/inositol-hexaphosphate#

@gge

Hi, that "Preparation Methods" information was just shared to let others, who read this topic in this forum, know that those Methods can be "very effective in reducing" phytic acid --- so should avoid accordingly if wanna raise phytates intake from foods.

I'm still learning, so please continue to share to exchange information about "Phytic Acid / Phytate / IP6" under this topic in this forum 🙂

Thanks.

Kimster

@gge

Hi, I also noticed this mskcc.org website information, but did not add it to the first post.

Thanks for sharing to add it to this topic for others to read it 🙂

Thanks.

Kimster

Posted by: @johan

Posted by: @kimster

Dear Friends in this website,

Hi, I'm creating this "Phytic Acid" topic as noticed its benefits --- but it seems that "Phytic Acid" has not been discussed in this website if not mistaken.

https://mayoclinic.pure.elsevier.com/en/publications/inositol-hexaphosphate-plus-inositol-induced-complete-remission-i
Inositol hexaphosphate plus inositol induced complete remission in stage IV melanoma: a case report

 

Thanks.
Kimster

Hi Kimster, great find! IP6 is one of my favorite supplements and easily added to our diets by eating plenty of beans. 

Here's a great video, very motivational, by Dr. Joel Fuhrman MD

https://www.youtube.com/watch?v=76XklHNzWx0&feature=emb_title

I started eating beans after reading his books, and videos by Dr. Michael Greger MD.

It's now my favorite food and eat beans at least once a day.

Glad you brought this up!

Hi, which would be your favourite IP6 supplement if you have tried any from the market.

Just would like to "learn to understand more" about IP6 supplement.

--- For example, good to read (to learn) the "marketing" information from the following IP6 supplements:

https://www.ip6gold.com
https://www.ip6gold.com/faq

http://www.longlonglife.org/en/transhumanism-longevity/anti-aging-supplements/ip6-immunity-booster-against-cancer-anti-aging/

https://www.naturesway.com/Product-Catalog/Cell-Forte-w-IP-6-Inositol-120-Veg-caps

https://www.naturesway.com/Product-Catalog/Cell-Forte-w-IP-6-Inositol-(powder)-14-6-oz

https://www.jarrow.com/product/115/IP6

https://www.sourcenaturals.com/products/GP1163

There have been discussions about Curcumin supplements in this website, so now could start to learn a bit about this IP6 supplement.

Thanks.

Kimster

Posted by: @kimster

I also noticed this mskcc.org website information

Do you know of any other cancer forums where more info on IP6 anti cancer effects are discussed, may be someone has even tried it?

Posted by: @kimster

Hi, which would be your favourite IP6 supplement if you have tried any from the market.

IPGold, a blend of inositol and ip6, is one of the first supplements I bought for my sister-in-law, when she was dx with ovarian stage 4, now almost 4 years ago. There are other similar products, but that's the one we used.

Btw, here's a screenshot of my 1st order, it was about US$5 cheaper in 2016. Later I started buying some plain Inositol from NOWfoods.

Posted by: @gge

Posted by: @kimster

I also noticed this mskcc.org website information

Do you know of any other cancer forums where more info on IP6 anti cancer effects are discussed, may be someone has even tried it?

Hi, I have not checked other cancer forums in other websites - it's a good idea to try to gather more information from other sources.

I just noticed this website:

https://bwi.forums.rivals.com/threads/want-to-prevent-cancer-kill-cancer-cells-take-ip-6-inositol-found-in-rice-bran-etc.238919/

Link to research site:
www.ip-6.net

Thanks.

Kimster

Oh, and i'm not affiliated with any of these supplement companies, just showing some proof to back up what I'm saying.

Posted by: @johan

Posted by: @kimster

Hi, which would be your favourite IP6 supplement if you have tried any from the market.

IPGold, a blend of inositol and ip6, is one of the first supplements I bought for my sister-in-law, when she was dx with ovarian stage 4, now almost 4 years ago. There are other similar products, but that's the one we used.

 

Hi, thanks a lot for sharing information from your experience.

Thanks.

Kimster

Posted by: @johan

Oh, and i'm not affiliated with any of these supplement companies, just showing some proof to back up what I'm saying.

Hi, we all sure understand that 🙂

Thanks again for sharing.

Kimster

Posted by: @johan

IPGold, a blend of inositol and ip6, is one of the first supplements I bought for my sister-in-law, when she was dx with ovarian stage 4, now almost 4 years ago.

Can you tell us if it seemed to help her?

Posted by: @gge

Posted by: @johan

IPGold, a blend of inositol and ip6, is one of the first supplements I bought for my sister-in-law, when she was dx with ovarian stage 4, now almost 4 years ago.

Can you tell us if it seemed to help her?

It's impossible to know, gge. She has taken quite a few supplements, especially during that first year. There's no doubt in my mind that chemotherapy has worked for her until now, and I think she benefited most from a weekly reduced dose schedule vs the regular full dose once a month or so. If you then support the immune system with good healthy food, supplements etc  I believe that's an effective combination.

Posted by: @kimster

@daniel

 

Dear Daniel,

Hi, thank you very much for your reply to this topic --- as I was not sure whether friends/visitors in this website would notice this topic or not.

I also just realised there were such a case report when I was reading the information from this website:
https://thesoynutritioninstitute.com/soy-high-phytate-foods-may-help-prevent-cancer/

Much of the work involving the role of phytate in reducing risk of cancer of all types has been conducted by Dr. AbulKalam M. Shamsuddin and colleagues from the University of Maryland School of Medicine.
They postulate that the anticancer potential of phytate is due to a combination of antioxidant, anti-inflammatory, and immune-enhancing activities.
Inositol and IP6 may work together additively or even synergistically.
Nevertheless, despite a fair amount of promising research, it is fair to say the anti-cancer properties of phytate haven’t received a lot of attention over the years.

That is one reason this conclusion by Khurana and colleagues caught my attention: “Although this is a single clinical case showing IP6 + inositol’s potential role in controlling our patient’s stage IV disease and spontaneous regression of primary melanoma, and rarely metastatic melanoma has been reported in literature, we believe that there are ample preclinical and clinical data to suggest that this nontoxic, readily available supplement should be evaluated in clinical trials for its antitumor activity.”

The patient in question had metastatic melanoma but declined traditional therapy and opted instead to try an over the counter supplement of IP6 + inositol.
The patient achieved a complete remission and remains in remission 3 years later.
The patient took daily 4,000 mg of phytate and 1,100 mg of inositol.

------------------------------------

Hopefully in the future, Daniel would create a "main" article to introduce this IP6 when there is more information to be shared with friends/visitors in this website --- as not sure whether this topic created in the forum would be noticed by many friends/visitors of this website.

 

Would MCS Formulas consider selling this "nontoxic, readily available" IP6 supplement in the future?

- as this IP6, as natural antioxidant, seems to have other benefits as explained in this:

https://onlinelibrary.wiley.com/doi/full/10.1111/1750-3841.13320
Phytic Acid: From Antinutritional to Multiple Protection Factor of Organic Systems

Thanks.
Kimster

Hi Kimster,

Thank you very much for the links. It will certainly be on the top of my list for addressing new posts since it meets the criteria regarding science and published case report. Because of the same reason, we will strongly consider it as part of the new products we will have available at MCS Formulas.

According to the case report, stating this:

"The patient was offered systemic therapy with both immunotherapy and targeted therapy but he declined both and instead elected to pursue the combination vitamin IP6+inositol (800 mg/220 mg), five tablets in the morning and five in the evening daily"

This formulation sounds a little misleading but I think you are right: the total was 10 capsules (each of 400mg IP6 and 110mg inositol).

Kind regards,
Daniel

Posted by: @daniel

According to the case report, stating this:

"The patient was offered systemic therapy with both immunotherapy and targeted therapy but he declined both and instead elected to pursue the combination vitamin IP6+inositol (800 mg/220 mg), five tablets in the morning and five in the evening daily"

This formulation sounds a little misleading but I think you are right: the total was 10 capsules (each of 400mg IP6 and 110mg inositol).

 

The language sure is ambiguous. For the sake of those who will want to follow this same treatment, would Kimster, Daniel or someone be so kind to ask the authors what the exact dosage was? Could it be (10) pills of 800 mg of IP6 and (10) pills of 220 mg if inositol a day? Or they didn’t make pills that size back then?

@gge Done! I just sent an e-mail to the author. If I receive an answer I will post it here. Kind regards, Daniel

Posted by: @kimster

Inositol hexaphosphate plus inositol induced complete remission in stage IV melanoma

 

Posted by: @daniel

high dose of a specific supplement has to be used in order to be able to expect effectiveness.

The IP6 + inositol combo looks very interesting indeed: no serious side effects, apparently affects only the cancer cells, easily accessible, inexpensive, has improved the condition of a few patients, and most importantly, a stage IV melanoma patient reportedly got cured just with it, no conventional therapy.

Is this just too good to be true and thus untrue? We hope not but we don’t know yet if it is repeatable.

It seems to require quite a few pills or capsules a day though. This might be a problem for many people since most cancer patients already take too many medications.

I wonder if the dose required could be substantially reduced if these 2 substances could be encapsulated either in chitosan (and thus be a totally natural treatment) or in liposomes so that all the IP6 and the inositol go into the cancer cells only and thus smaller quantities are needed.

Any thoughts?

@gge

Taking a big amount of capsules could be a problem for some people, many seem to handle it well. Also, often you can just poor the content(powder) of capsules into juice or a smoothie.

It's a remarkable recovery to say the least. 

Green tea could be a good addition to inositol:

https://pubmed.ncbi.nlm.nih.gov/17574044/

Posted by: @johan

@gge

Taking a big amount of capsules could be a problem for some people, many seem to handle it well. Also, often you can just poor the content(powder) of capsules into juice or a smoothie.

It's a remarkable recovery to say the least. 

Green tea could be a good addition to inositol:

https://pubmed.ncbi.nlm.nih.gov/17574044/

 

 

Hi, thank you very much for sharing the "combined" benefit information.

I also noticed the "synergistic" benefit information from:

https://scialert.net/abstract/?doi=ijcr.2012.49.62

https://scialert.net/fulltext/?doi=ijcr.2012.49.62

Synergistic Effects of Green Tea Catechin and Phytic Acid Increases the Cytotoxic Effects on Human Colonic Adenocarcinoma Cell Lines

Published: March 21, 2012

Thanks.

Kimster