Afatinib, sold under the brand name Gilotrif among others, is a medication used to treat non-small cell lung carcinoma.

Typically  Afatinib is given at a dose of 30 to 50mg/day, but it has been proposed to be used at 150 to 300mg/day, followed by 6 days no-drug. 

Here is a thread on Inspire discussing the fact that some oncologists are in favour of this approach https://www.inspire.com/groups/american-lung-association-lung-cancer-survivors/discussion/pulsing-afatinib/

Here is a post from Inspire  on experience of patients using the pulsed option:

"Mikepo,

My mother, after being on Afatinib at 50mg per day for a month decided to switch to pulse. She has LMC. Her oncologist had her take a week off drug to recover, then she took a 300mg dose of Afatinib. Within 3 days her bladder function returned (she has had a catheter for 6months following the Leptomingeal diagnosis). And, to top it off, had zero side effects besides fatigue. She had many more side effects on the 50mg per day. She's had another week off drug, and will do another pulse dose today. I am a BIG fan of pulse so far, and hope some of these other neuro effects clear up too. Thr specialist that told us about the pulse dose is not surprised she's tolerating it better than the daily 50mg. That's been his experience too. At the 50mg per day, you see only side effects, not much good effect. The concentration needs to be higher to really get into the BBB. I knew the very next day that the pulse had worked because my mom wasn't slurring her speech. And, she said she felt better than she had in months. Nobody thought she'd regain bladder function. Nobody. We hope this is sustained.

Good luck to you. Don't fear the pulse, it's a very good thing.

Amy"

And here is a very recent post from Lars who is helping his wife fight lung cancer. They started this pulsing method and they do see very good results https://alunglife.com/week-214-13-brain-mets-all-shrunk-or-gone-due-to-pulsed-afatinib/ They use 150-200 mg afatinib once a week.