"Inhalation treatment of primary lung cancer using liposomal curcumin dry powder inhalers"
".In this study, curcumin and its liposomal formulation were directly administered to the lungs of rats with lung cancer via pulmonary delivery, where the bioavailability and metabolism limitations of curcumin do not exist. Furthermore, our investigation of the anti-lung cancer mechanisms of curcumin demonstrates that the strong anti-oxidative and anti-inflammatory effects and the improvement in apoptosis induced by curcumin significantly contribute to its anticancer effect. More importantly, the liposomal formulation highly enhances the effect of curcumin by overcoming the water solubility limit and increasing cell endocytosis. This inhalable liposomal curcumin formulation is a promising pulmonary medication for the treatment of lung cancer."