"Lumefantrine promoted growth suppression and apoptosis in vitro in parental and radio/TMZ-resistant GBM and inhibited tumor growth without toxicity in vivo in U87MG GBM and radio/TMZ-resistant GBM orthotopic tumor models. These data reveal that lumefantrine, an FDA-approved drug, represents a potential GBM therapeutic that functions through inhibition of the Fli-1/HSPB1/EMT/ECM remodeling protein networks."

https://www.pnas.org/content/early/2020/05/13/1921531117

" a heightened expression of Fli-1 has been observed in other types of cancers, including melanoma, ovarian cancer and breast cancer. For this reason, the researchers are hopeful that lumefantrine could play a role in boosting the effectiveness of other cancer therapies, too."

https://newatlas.com/medical/approved-malaria-drug-brain-cancer/