Your Contribution Needed on Breast Cancer Story from Emad

Dear Friends,

On the same line as the post from Ergin, https://www.cancertreatmentsresearch.com/your-contribution-needed-on-ovarian-cancer-story-from-ergin/ I would like to invite you if you could please share here ideas and experience that may be relevant to Emad and his dear mom.

Off course, as the disclaimer is also stating, this website is not intended to offer medical advice but to try and get together as much collective knowledge as possible, so that finally, together with our medical doctor we make informed and successful decisions regarding our treatment strategies.

Here is the message from Emad:

 

Dear all , my name is Emad Abushofa , from Libya

In 2012 my mother diagnosed with metastatic breast cancer , Estrogen positive , Her2 negative

Tumor marker was about 500, she was walking hard because of mets in her legs

After 9 cycles of chemo then radiotherapy , the tumor marker declined to 30 , and she became able to walk normally again

Then she started on hormonal therapy , but the markers were raising slowly

Until August  2015 , the tumor marker became 2000 , so decided to return to chemo

She took  6 cycles of taxotere ( also I added DCA + Natural protocols like Budwig , MSM LIPH , Juicing , Liposomal Vit C)

The tumor marker declined from 2000 to 353

After another 3 cycles , but this time only chemo , the marker rised to 712

Then the oncologist changed the chemo to 5FU and venorelbine , 2 cycles with DCA , the tumor marker declined to 450

Then I stopped DCA few days and didn’t give it before chemo , the marker rised to 558

Then again DCA with chemo + artimisnin + baicaline , decline to 450

Then I run out of everything , marker rised to 714

Changed the chemo to Gemzar + Carboplatin , 3 weeks per cycle

Cycle 1 : chemo alone , decline from 714 to 685

Cycle 2 : chemo then DCA IV added lately (not before chemo) , raise to 699

Cycle 3 : chemo + DCA IV , decline to 517

Cycle 4 : chemo + DCA IV + one shot half dose Salinomycin base version , decline to 408

Cycle 5 : chemo + DCA IV + one shot full dose Salinomycin base version , decline to 317

Then we stopped 2 weeks because of blood transfusion , also runout of Sal

Cycle 6 : 2 weeks DCA IV only, then half dose chemo with DCA IV , raise to 380

Cycle 7 : chemo + DCA IV , decline to 350

Cycle 8 : chemo + DCA IV + 3 shots Salinomycin sodium salt version , decline to 330

Cycle 9 : chemo + DCA IV + 4 shots Salinomycin sodium salt , decline to 320

Then another stop for 2 weeks because of blood transfusion (DCA IV  + one shot Sal)

Cycle 10 : 75% chemo , DCA IV + procaine IV + high dose lansoprazol + 1 shot Salinomycin sodium salt in the same day of chemo

Tumor marker raised from 322 to 607

 

Few notes :-

1-     I started to give procaine IV just 2 weeks ago , 2ml of 2% solution , half an our before DCA IV

2-     My mother always had a marked tremor when using Sal , sometimes strong

3-     First 3 days of chemo I give my mother 180mg lansoprazole per day , then 80mg for other 4 days

4-     The mets on my mothers bones are small and stable for along time , but the mets in her liver are trying to grow fast , 5 spots less than 1cm , 3 spots between 1cm to 2cm

5-     Im not sure about the last chemo cycle, we felt like they didn’t give my mother the proper dose

Now I only have DCA + procaine, I have 100ml MethylGlyoxal , no more Sal

 

I will be happy to listen from you , your opinions will always help us

Thank you so much

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Ergin
Member
Ergin

Emad,
My brother,my friend.
No one can catch except a few people.
But i catch because i know you.
***23mg/kg MG***
This word consists full of knowledge and smells help to others.
This is a real human clinical trial although one person but very precious person,our mother.
Thank you Emad for humanity,i wish one day everyone will share his/her experiences here wlth talking on dosages.
Kind regards
Ergin

Emad
Member
Emad

Thank you always dear Ergin

sharing everything about our protocol is the smallest help I can give , and unfortunately I don’t seem to be helpful more than that

also I really wish if other people just give some time to share what they are doing , it doesn’t make sense to just watch and not even giving some time to write few words that may help other readers

Emad
Member
Emad

We are switching back to 3-BP and Sal after we run out of MG

we can’t know if MG did anything , we may know if my mother went to Germany for another MRI scan and TACE

still we are trying to gain more help from the government to continue do 1 or 2 more TACE sessions , 6 weeks passed since the last one

Emad
Member
Emad

Fighting these days with the port a cath , its partially blocked , I just administrated 2/3 of the 3-BP bag , and throw the rest of it because its no longer getting through the port , it was like throwing a part of my body , it was a bad night

yesterday I tried to administrate only NaCl to see if its going through the port normally , and it did go normally like there is no problem , I don’t know how

today tried to give NaCl again so if things went good then I will give Sal , but strangely the problem did return again and it was like blocked , so I will just try to give it tomorrow

also the skin near the port is inflamed , and some of the administrated fluid is leaking out of the port

the next TACE session will not likely be soon

my mother started to feel some pain near her ribs

I don’t know whats happening inside , but I must do something regarding IV administration or we will face undesired problems

Ergin
Member
Ergin

My brother Emad,
Very sorry to hear that bad happening.
I am also in a very bad situation.She was nearly passing away 2 days ago.And still she is not good.We are in hospital from days.Also ascite in lungs.Kidney tube etc.
I have a good news:May be Daniel hearth about it.
I know a patient survived by this.And oral usage.
When i learn more,i ll update.
https://www.ncbi.nlm.nih.gov/pubmed/26873189
Kind Regards
Ergin

Emad
Member
Emad

I’m sorry to hear this brother 🙁

please do your best , she must survive

I didn’t hear about this approach , hope it the key for success

I believe on you brother , tell me if I can help in anyway

Meech
Member

I don’t have a port-a-cath in but I do have a nephrostomy tube, which is essentially a catheter that’s implanted through a hole in the back, into the kidney, to drain urine into an external bag.

I’ve had it for a year and had issues similar to this the entire time. Firstly, internal (kidney) infections due to the tubing. The body isn’t made to have rubber and plastic in it at all times, long term. In the year, I’ve had an infection almost every month. Secondly, external infections, from fluid draining around the catheter. Thirdly, blockages of the tube due to sedimentation. This can cause fluid (in my case, urine) to leak out of the wound as opposed to travelling down the tube. Fourth, the tube coming loose and out of place. Again, this can cause leakage of fluids around the tube. I’d suggest going back to interventional radiology and having the tube inspected. I’ve been five times since the start of September to have the tube changed entirely, so these issues do happen and they can happen frequently despite your best care.

Emad
Member
Emad

Hi Meech , thanks for helping on this

yes as you said I did read about this and its suggested to visit a radiologist to inspect it

also I started to give antibiotics today to my mother , just in case because there is inflammation around the port and I was fighting a lot with it and the risk of infection is getting higher when doing such things

hope just I can somehow un-block it so I can continue my career in doing IVs

marcosbomber901
Member

Hi Meech
Can you tell me the dose of januvia,propranolol,celecoxib,omeoprazol you recommended Dr. Jason Williams after the crioablation-immunotherapy

thanks

Meech
Member

– Cyclophosphomide 50mg every other day, for 3 months

– Januvia 25mg every day, 7 days on, 7 off, for 28 days

– Cialis 5mg every day for 3 months

– Protonix 40mg per day for 1 month

– Celecoxib I take because I’m on a blood thinner. I take 200-400mg daily. They normally recommend Aspirin 81mg-100mg 2x daily.

marcosbomber901
Member

Hi Meech
Thank you very much

Meech
Member

Of course. I hope it helps.

marcosbomber901
Member

Hi Ergin
I feel much the situation of your mother Ergin, my pain is your pain.If i can help let me know

Ergin
Member
Ergin

Believe me friends i firstly cry when i saw your messsges from years.
I feel that i have best friends

Ergin
Member
Ergin

A very big secret,
I gave her dissacharide coated nano silver in hospital while.drs said there is a big peritonitis on abdomen.The ascite was full of leukocyte and eritrocites.More than 10.000.
I saw ldh 350 after nano silver.It was 170.I am not sure but what is this?
She is now on full.of antibiotics.
Yesterday we hopefully gave caelyx.
Very very big pain on kidney after operation,morphin didnt release pain.
I ll update.

Emad
Member
Emad

Continue with it Ergin , always do your best

I’m praying for both you and your mother to see improvements soon

Ergin
Member
Ergin

Emad please read this article,especially look at mice test.Today we are begining.
http://www.flora-balance.com/temp2/c-2005-7-cytoskeleton-disruptor.pdf

Emad
Member
Emad

I believe you will do it Ergin , glad to here you are starting it

I wish to hear good news soon and better improvement of your mother , God give her healthy long life

Ergin
Member
Ergin

My brother Emad,this must be lesson for everybody.I have full of valuable drugs in refrigerator and never used.
I was waiting for chemo alone to work from months and if chemo doesnt work i was planning to use others.
But when chemo doesnt work,it goes like a rocket.I miss those stable days.
Daniel has a good sentence, using chemo without sal or 3-bp,phlorizin etc.,it is an opportunity lost.

Emad
Member
Emad

Dear Ergin , we all lost a lot of opportunities in this fight and still losing some

but when the fight is still on , this means we still have time to do what we want , and still there is opportunities left for us

praying to hear good news soon

Ergin
Member
Ergin

Dear Emad,
Thanks alot.I believe too much to oleuropein liquid form which we are using now.Something changed i feel i saw a good responce or a placebo effect,i dont know.
Please search for it i ll send you a bottle this week.
Kind Regards
Ergin

Emad
Member
Emad

Thank you always Ergin , may God show us more improvement soon

Emad
Member
Emad

Today we visit the doctor , he is the first Libyan doctor who did place a port to a patient in Libya

unfortunately he said its blocked and can’t be opened again , and the membrane of the port is teared

so I guess I will stop giving IVs for a while

I have about 7 to 8 3-BP shots , and 3 Sal shots , I wonder if its a good idea to give 3-BP orally now , and if its ok to give Sal IV with a canula placed in the arm , or should I pay 250 euros to place the port with another new one so I can continue to do what I love to do

hope I do the right choice

Jcancom
Member

sirsna,
I had not understood that you are coping with cancer in the liver.
I wish you good luck!

sirsna
Member

Thank You, this situation is new to me, too (I mean mets in liver) – there was nothing in Pet scan 7 month ago in liver, but now in all globes multiply, super negative dynamics.

Jcancom
Member

sirsna, have you heard of deuterium depleted water (DDW)?
The science has been building over the last 25 years and it has reached the clinic.

Apparently you can make your own with about 100 ppm Deuterium
by simply freezing and thawing filtered water 4 times.

You could then add in some of the commercial suppliers product
to modify the deuterium content from there.

I had not realized this until this past weekend, yet it appears that DDW
actually has an anti-cancer effect related to a metabolics. It truly is
amazing! Are all cancer treatments based on metabolics?

DDW could be added onto your treatment plan. I would love to hear
D’s view on how this could be amplified by other metabolics.

ovidiu
Member

I mentioned DDW in a collection of possible treatment enhancements for pancreatic cancer, although it wasn’t tested for that cancer.
https://www.cancertreatmentsresearch.com/alternatives-in-advanced-metastatic-pancreatic-cancer-by-ovidiu-herlea/
However, DDW seems effective in breast cancer (DDW caused human breast tumor regression in mice).
Here is the site where I bought some for one of my cats (she is 19 years old).
https://www.drogheria.ro/produs/apa-cu-continut-scazut-de-deuteriu-25-ppm-qlarivia/

Jcancom
Member

ovidiu, I was quite surprised to read that DDW also works through the metabolic network.
It is very surprising how much cancer truly is a metabolic disease.

Yet, I was looking yesterday at what is considered the leading the leading cancer textbook: there is not
a single mention of metabolics and cancer. It is not that there is a small writeup; there was NO writeup!
How can someone be a cancer doctor without some understanding of the metabolic perspective?

I do not see how there can be any possible doubt that a cure for cancer runs through metabolics.
I sure do not have any doubt.

As we have seen there are a large number of metabolic approaches, many of them non-toxic,
that have some degree of effectiveness in cancer. Finding a way to properly combine some of
these different approaches should give a powerful anti-cancer treatment.

Jcancom
Member

Wow!
ovidiu, 14 Romanian lei =~ US $3

I had no idea that DDW could be so affordable and 25 ppm is very very depleted of Deuterium.
You might want to start more at 125 ppm and work downwards. I had thought that this would
cost hundreds if not thousands of dollars.

Any idea of how much shipping for a bottle would be?

ovidiu
Member

@jcancom: 14 RON is for half a liter (they only bottle them in 0.5 liters…), so a months supply of about 50 liters is about 1400 RON or 300 euros. I don’t know about shipping abroad, in Romania above a certain amount ordered the shipping is free. You could contact the store and ask about long distance shipping.

No, you don’t start at 125 ppm, since you have to get there or lower for your entire body water. Depending how much DDW you drink daily (you can use diuretics and spend more on DDW to get there faster) you can gradually decrease your bodies’ deuterium concentration. The articles I read mentioned as the primary problem the time needed to get the deuterium concentration low before the cancer progresses too much. They also mention the direct injection of DDW into sarcomas (which did not respond to oral DDW).

Jcancom
Member

$3 a bottle seems like such a great deal.
This is one of the examples where you have thirsty customers wanting a product
and the only question is how can you bulk ship it to them at a reasonable price?

I would think that ordinary freight would be very expensive.

It looks like it would only cost $1000 per TEU (11k ft^3, 21k kg), to the US East coast.
40,000 bottles of 25 ppm DDW = $1000 shipping cost.
2 cents a bottle to ship.

https://moverdb.com/freight-costs-usa/

sirsna
Member

Hi!

Thank You Emad, for Your kind description.
Than You, Jcancom, for more ideas.

As I said I had liver biopsy, which confirmed BrCa mets in liver. My primary cancer was with hormone receptors ER100%, Pr80%, AR100%. Now liver metastases is triple negative.
I decided to take systemic chemo Carboplatin + Docetaxel. Fasted few days prior, in the chemo day (yesterday), and fast continues today, I think till tomorrow midday. My blood glucose was very good – 3.0-4.0, blood ketones 2.1-3.0. Except shortly after chemo infusion blood sugar jump to 7, then after few hours to 5 and this morning was again 3.2-3.9. I also take metformin and simvastatin.
Do You have any ideas, what to add to systemic carboplatin. Maybe intravenous vit C?
I have not eaten for 4 days and feel very good, just few episodes of nausea.

Kindly,
i.

Alex
Member

Dear Sirsna, please look into anti-angiogenesis, https://www.youtube.com/watch?v=OjkzfeJz66o
I can think of no better video to try to explain it.
It would not be without side effects but may help you.
Almost al cancers require angiogenesis, inflamation, energy.
Messing around just a bit with the basics, MAY give good results, or help you get better results, however if not careful the opposite could be true.
Talking to the doctor/s about this, is important when making decisions.
Best of luck,
Alex

sirsna
Member

Thank You Alex, for this link.
As my cancer is highly advanced now, diet is not enough. I am now goint to the intermittent fasting/keto diet side, just I will be very careful with fats.

I have many questions in my mind where I do not have enough knowledge:
As Carboplatin is weak acid I can not add Basentabs or Omeprazole. I am already on Simvastatin and Metformin (I have option to change metformin to Berberine if liver enzymes will be to high)
can Carboplatin be coadministered with Aspirin, Dipyridamole, Mebendazole?
I will try to get perscription from my doctor for Dapagliflozin tablets.
Can Baicalen be taken in interval between chemo infusions (every 3 week)?

How often You suggest to check blood counts? Two weeks after chemo infusion is ok?

Kindly,
i.

Alex
Member

Dear Sirsna,
The speaker in that video, is also talking about anti-angiogenic drugs that can be used against cancer, the diet part is mostly for prevention, once advanced cancer is established, diet becomes less and less a priority, so it seems, while trying to not make the cancer happy, it’s also important to feed yourself, don’t starve yourself thinking it will kill the cancer, advanced cancer always finds a way to survive, but it may also have weaknesses, genetic profiling of the tumor cells may help in that direction, timing and strategy is also another big one. A plan must be devised by your doctors, once they have the information they need.
About anti-angiogenic drugs and the rest, i would talk to the doctor/s, if in doubt and left without competent assistance, look inside and do as you feel when you feel it.
Sometimes personal intuition and instincts can be helpful.
Also do your best to minimize money waste, everything counts when you’re not rich.
Economics is sadly an often factor in the fight against cancer.

I can only hope my reply will at least give you some peace of mind, some order in all the chaos.
Hugs,
Alex

ovidiu
Member

@sirsna: actually, you could add a proton pump inhibitor to the Carboplatin + Docetaxel chemo. This study of Esomeprazole (I don’t understand why they didn’t use Omeprazole or Lansoprazole, they are safer) in advanced breast cancer looks promising.

Intermittent high dose proton pump inhibitor enhances the antitumor effects of chemotherapy in metastatic breast cancer.
https://www.ncbi.nlm.nih.gov/pubmed/26297142

sirsna
Member

Hi, Ovidiu!

I red this idea from Daniel`s posts, that some chemos are weak bases and others are weak acids.
And this is also from Daniel`s ideas : Proton pump inhibitors will help the chemotherapies that are weak bases (most of the chemos are this type) and will NOT help the chemos that are weak acids.

“the acidic milieu of the extracellular medium promotes the uptake of weakly acidic drugs, such as cyclophosphamide and cisplatin and thus increases their cytotoxicity.”

“Cisplatin, being a weak acid, exhibits significantly greater uptake from acidic milieu,
resulting in increased intracellular accumulation and heightened cellular toxicity.”
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5243979/

Carboplatin is also weak acid.
Metformin and ketone bodies (as effect of fasting or keto diet) can produce lactic acid. As I understand this could be quite acidic environment.

And again, Daniel has commented this article You shared :

“Yet, maybe in this trial it worked because chemotherapy was preceded
by three days esomeprazole and the first day they gave Taxol and only
in day 4 they used Cisplatin.”

ovidiu
Member

@sirsna: from the article I linked before (they don’t give much importance to the ph of the chemo):
We have recently shown that particularly cisplatin resistance of human malignant tumors may be the result of both tumor acidity and the release of nanovesicles called exosome. In turn, also exosome release from cancer cells is highly increased by environmental acidity and proton pump inhibitors or buffering procedure dramatically inhibit exosomes production by cancer cells.

A different approach for TNBC might be the use of Selamectin, which decreases metastasis and may sensitize the cancer cells to Tamoxifen.
Selective Inhibition of SIN3 Corepressor with Avermectins as a Novel Therapeutic Strategy in Triple-Negative Breast Cancer.
https://www.ncbi.nlm.nih.gov/pubmed/26078298

sirsna
Member

Thank You for info.
Now I am confused about PPI. I used Omeprazole from ~april, but now discontinue some weeks before chemo.

I never heard of Selamectin, Avermectin and Ivermectin. Looks promising. But it always take time to get medication “in the house”.
I have Mebendazole tbl. “in pocket”, but I do not take them now. What do You think about Mebendazole in my situation?

ovidiu
Member

You don’t have to discontinue PPI “weeks before chemo”, although I am uncertain about the optimal schedule…
Mebendazole – I couldn’t find something about it and TNBC. Flubendazole appears to be useful against breast cancer stem-like cells, but has very poor bioavailability.
Flubendazole, FDA-approved anthelmintic, targets breast cancer stem-like cells.
https://www.ncbi.nlm.nih.gov/pubmed/25811972
Flubendazole overcomes trastuzumab resistance by targeting cancer stem-like properties and HER2 signaling in HER2-positive breast cancer.
https://www.ncbi.nlm.nih.gov/pubmed/29080749

I was reluctant to mention Selamectin because it’s studied only for veterinarian use, I couldn’t find data about human pharmacokinetics, also nothing about interactions with other drugs.
If you are brave and willing to experiment, you could try swallowing the topical solution for large dogs, that’s 360 mg (in Romania it’s about 15 euros).
For my cats I have used Selamectin topically frequently at 10 – 12 mg / kg dose, without side effects, in the absence of other medication (except vitamins, Liv52, Essentiale and Cranberry extract).
From the existing data on cats, I guesstimate the elimination half-life of Selamectin in humans to be around 4 days (30% longer than in cats, usual ratio for other drugs).
Pharmacokinetics of selamectin following intravenous, oral and topical administration in cats and dogs.
https://www.ncbi.nlm.nih.gov/pubmed/12213114

sirsna
Member

Just found this – can this be because diabetes drugs tend to decline alkaline environment?

Diabetes drug dramatically boosts power of platinum chemotherapy
https://news.harvard.edu/gazette/story/2007/05/diabetes-drug-dramatically-boosts-power-of-platinum-chemotherapy/

Meech
Member

Daniel would recommend holding off the metformin for a length of time before chemo.

sirsna
Member

Hi Meech !
I remember this idea about stopping metformin shortly before chemo and then restart in one day with chemo.
But is this idea good for both acid and base chemotherapies?

sirsna
Member

Thanks, Daniel !

So from this point of view (reducing the activity of cancer cells) – what do You think of Keto/fasting prior Chemo?
Walter Longo suggest it as it could minimize some side effects as neuropathy and could enhance some of chemotherapies.
i.

Carl
Member
Carl

Thanks for the analogy! What you are saying makes sense.

Do you think statins are powerful enough to normalize the cholesterol values that may be elevated from fasting?

sirsna
Member

Thank You, Daniel, for explanation. It clarify things for me.

Interesting, that my blood ketene levels raised also in the presence of Statins (I somehow thought that statins will not allow to ketones appear).

Emad
Member
Emad

Dear all , hope you all are fine and doing good

and sorry for not showing a lot these days

I have a new update

my mother did her fifth TACE today

but Prof Vogl said that the results are mixed

a part of her liver tumor did shrink a little bit , but also there is a part that increased in size

also he said that the increased part is the reason of why my mother feels weak and tired

also Prof Vogl said that the increase is because we didn’t come in the right time , its been 11 weeks since the last TACE

—–

I don’t know the overall result , my father didn’t tell me everything yet , I feel bad and scared a lot

the strange thing is that all the mets around her body are stable like always , but the liver tumors are like a hell 🙁

sirsna
Member

Hi, Emad !
How are You ?
How is Your Mother ? I hope treatments keep her stable ! Do she still visits prof. Vogl ?
i.

Emad
Member
Emad

I’m fine , just busy because I started working from the early morning to late night

my mother aren’t doing good , she is barely moving most of the time , very tired and feels pain all over her body

not because of TACE , its complicated , low HB , she also catched a cold , there is inflammation in her left lung

yesterday was the 5th TACE session , in general all the tumors on the liver did shrink even after 2.5 months from the 4th TACE

but there is a clean area in the liver which wasn’t targeted by TACE , and because of delay of treatment the tumors did grow there

but all the other parts of the liver tumor did shrink

we have to continue for now , we don’t have any other option

also to mention , one of the important things I forget to mention , I didn’t give my mother any other treatment , I used to give my mother 3-BP , Salinomycin , DCA or Methylglyoxal

but I didn’t give anything in the last 3 months

————————

how things are going on your side ?

hope things are under control with the current treatment you are doing

always wish the best for you sirsna

Emad
Member
Emad

Update

sent from prof Vogl

Pre-recording of 20.10.2017 on the correlation present.
Significant increase of intrahepatic lesions in both liver lobes, exemplarily in the liver segment 4/8 currently 6.7 x 6.3 cm, previously measuring 4.4 x 3.6 cm, further focal lesions in liver segment 4 currently 6.9 x 5.0 cm, previously 3.7 x 3.9 cm measuring. As well as significantly increasing lesions in the left lobe of the liver.
No cholestasis.
Unchanged representation of the kidneys. Unchanged renal cyst on the right side.
No adrenal cavity.
Minimal perihepatic free. Fluid can be delimited.
Increasing para-aortic and mesenteric lymph nodes in the upper abdomen.
Gross increase of intrahepatic lesions in the course.
Progressive disease.
Friendly greetings

Jcancom
Member

Emad, you are such a hero!
You have been doing such an amazing job.

Some suggestions: Vitamin C and E260

All day iv dosing of vitamin C.
This was my big new insight for 2017.
the original research from the 1970s found that Vitamin C was effective when given for prolonged periods.
Duration is more important than dose. (see Vitamin C thread).
Most patients experienced at the least rapid symptomatic benefit.

E260 would be a great one to have on the shelf if needed.
It specifically depletes energy supply in cancer cells.
This one could be better than 3BP!
There are several ways that you could amplify its its if needed.
You would need to do a 9 step synthesis.
A clinical trial is expected in a year.

You are such an inspiration to us on the forum!

Emad
Member
Emad

Thank you for being here with us J

the greate info you are sharing is the best thing can any human do in his life

I’m so much interested in this approach of using Vitamin C for longer duration , I will do my best to try it

regarding E260 , aren’t there any ready made source for it ? its hard for me to synthesis it

Jcancom
Member

Emad, you are doing such an amazing job! Month after month, it finally wears you down.
I am so glad that you added these kind words because I started to feel that I was not giving everyone the best possible information. I am giving the best ideas that I know of, though I suspect that someone else might offer even better suggestions. I firmly believe that the cure now exists, though it is not absolutely clear to me what it is.
Vitamin C might not be the absolutely best curative treatment, though the research found that most patients did feel better with the extended dosing. At a certain point in cancer, at least feeling better is very important. The symptomatic relief of serious pain and other problems would be a great relief for many.

I realize that going the synthesis route is an extra burden, though I think that this now needs to be stressed. Simple administration of raw chemicals should be avoided. There are so many of these advanced formulations now and many of them are not that difficult to make.

With E260 there are 9 steps and I have reviewed the synthesis again and I am developing an even better understanding of it. It does not look difficult. I have sourced all the needed chemicals at the chemical stores. I found 2 starter chemicals that look expensive through Sigma (they cost about $5000 for a 5g yield. Yet, other suppliers appear to offer these at much reduced prices.) Perhaps you could ask around to find someone who might be able to do this for you. It would be such a comfort for you to have this on the shelf. At some point progressive cancer simply becomes overwhelming and you need some option. E260 looks like a very solid standby.

The daily mouse dosing was 25 mg/kg –> 2500 mg for a 100 kg mouse –> 200 mg for a 100 kg person –> 100 mg for a 50 kg person (roughly). Best to start much lower than that possibly 1 mg per day. I think they dosed the mice twice a day peritoneally. There has been no dosing as of yet in humans, though the drug was designed to block FerT which in mice was only found in a sperm protein. I realize that this is not a perfect choice, though I hope that you find it a useful suggestion. The synthesis would take 2 or 3 days.

Other synthesis for example with 3-BP would also be worthwhile to consider. By synthesizing better formulations you then have a more effective drug with fewer side effects that will more specifically target cancer. It is possible that many people who have tried unformulated 3-BP would have done considerably better if they had used a liposomal or other delivery system.

I know that you are extremely stressed, though I want to try and reach you and give you advice that could help you. E260 might seem out of the way, though the recent article about it showed strong preclinical results. We both know that shutting off the cancer mitochondria in the way proposed would likely have very powerful anti-cancer effects while it would be reasonable to expect few side effects. Without active mitochondria, cancer cells would be EXTREMELY vulnerable. From the 1974 Scottish research into Vitamin C, a clear cell renal patient (This cancer type has few if any mitochondria) given only 1.5 days oral dose of vitamin C at 10 g per day developed a fatal TLS response on the third day. E260 appears to shut down mitochondria in a wide range of cancers. After this very highly specific first hit, almost any hit to glycolysis should have a massive anti-cancer effect. I am sure that it would be a great relief to you if the only thing that you had to worry about was that you had a cancer treatment that had even more treatment horsepower than was needed. This would clearly be one to have on the shelf just in case.

I hope my comments will be of help to you.
Best Wishes, J

Emad
Member
Emad

Thank you so much dear J

regarding Vitamin C , what do you think about the administration route ?

is it possible to gain a good results with any oral Vit C ? or better to use oral liposomal Vit C ? or its better just to use IVs ?

Jcancom
Member

Emad, iv would seem the best choice, though this could also be supplemented with oral and liposomal.
Probably to start you would want to go slowish as the tumor burden subsided. Need to be careful of TLS
and G6PD. Post to the Vitamin C thread and we could talk about this more.

Ergin
Member
Ergin

Dear Emad,
Please work on phlorizin with TACE.
That would be a powerful,perfect and a clear solution.I can sent a mail to your dr about phlorizin.
There is a good example in phlorizin patent.
They block the blood circulation on leg and gave phlorizin with chemo for melanoma if i true remember.
Kind Regards
Ergin

Emad
Member
Emad

Thank you bro for your support

I really wish if the hospital in Germany can give it but its unlikely

what I could do is to buy it and teach my father how to give it to my mother before doing TACE

to be honest I have a lot of things that I can give to my mother (Salinomycin + 3BP + MG + Phlotizin + Vit C)

from these choices I can only choose 2 maximum , I’m working day and night all the time just to make it possible to get more

and again Ergin , thank you for your suppot even when things are going very hard on your side

may God give your father a long healthy life

Ergin
Member
Ergin

Dear Emad,
I think you misunderstood my message or i misunderstood Tace.
I knew that you give chemo directly to the veins which goes to tumor in Tace.I mean a local treatment,isnt it?
If yes ,there is good option with phlorizin.
You first give phlorizin with Tace,NOT a 24 hour treatment ,it is very easy and local.We can discuss this.
Kind Regards
Ergin

W.
Member
W.

DEar Emad,

I am sorry you received bad news.

Can you please remind me if you already have tried 3-BP ?

Emad
Member
Emad

Hi W

I did 3-BP + Sal with the first and second TACE sessions , and the results were good

then I changed to MG with third TACE session and still things were good

but with the forth TACE I didn’t use anything , I run out of MG , and the port was blocked so I was no longer able to give 3-BP and Sal

I’m sure things get bad because we wasted so much time after the forth TACE , but also it looks like the problem was more than that , and what made it worse is because I stopped giving anything

W.
Member
W.

Hi Emad

It is clear you always did your best within your possibilities. You live in a messed up country with no constant access to the stuff you need and still you are here, fighting for your mother with internationally recognised experts.

with much respect,
W

Emad
Member
Emad

Thanks for your kind words W , it is supportive for me in my fight

I will do my best to make things better

best wishes to you

sirsna
Member

Dear Emad, sorry to read Your Mothers news.
Do You have next plan what to do?
Does she takes Basentabs?

I am just back from hospital from 4th chemo. Waiting for abdomen CT results. This time we were 5 women in hospital room, one young lady 31 years old, mother of 3, she has mets in brain, liver, lungs , pancreas, not yet histology report, but her cancer marker was high Beta hcg, some kind of placental cancer. Other woman was dying with lots of pain and ascites in abdomen. Not easy to see that all.

Jcancom
Member

sirsna, I have been very impressed by minicells as a cancer for quite some time now. It is hard to believe but in mouse experiments they achieved curative responses with nM doses of chemo. Very startling.

Minicells have moved into human clinical trials and the results have been somewhat mixed. There is a flu that develops that lasts for about a day and that has held back reporting the stunning results published in mice.

A few years ago another research team created a minicell strain that was GRAS (generally regarded as safe). This strain is expected to have no side effects due to a lack of LPS. This minicell treatment could have extremely impressive results. With the mice, it was possible to have curative responses using thousands of times lower chemo dosing.

https://translate.google.com.pg/translate?hl=en&sl=ko&u=https://www.google.ca/patents/WO2016140419A1%3Fcl%3Dko%26dq%3Dminicell%2Bcancer&prev=search

The original research was published 3 years ago, contacting the research group about this would not be a bad idea.
I would think that they would be very interested in accumulating human data. For a treatment many thousands of times better than chemo
it could be a great treatment for you.

PMID: 25341464

Best Wishes, J

Emad
Member
Emad

I’m sorry that you are seeing all this 🙁

its devastating , I hope it doesn’t let you down

no my mother is not taking basentabs , but the next plan is to do TACE like before but just try to come in time and not going late like before

also prof Vogl added Xeloda (oral chemo tablets) , and soon will return to use 3-BP , Sal and others when possible

I’m worried about how is the CT results ?

I will pray for your health

marcosbomber901
Member

Hi Emad
I hope that your dear mother this well with his treatment of TACE.might ask you a question, based on your experience with salinomycin, do you think that the salt is equally effective as the salinimicina that you can buy in Sigma Aldrich?.Thank you for your help Emad

Emad
Member
Emad

Hi marcos

my mother is still feeling weak and tired , the next TACE session will be after 10 days , we will see at that time how is the results

regarding Salinomycin, you mean the difference between the expensive base version and the cheap salt version ?

I didn’t notice any difference between the two versions , I used the base version twice , not enough to judge it , but it looks like the salt version , no clear difference in the effect , also no difference in the side effects

hope you are doing good my friend

i will answer any other question in details , just ask

wish you all the best

Emad
Member
Emad

New Update

2 days ago my mother did another TACE session

prof Vogl said that in general the results are good , there are a good tumor shrinkage on the right side of the liver , but on the left side there is a little bit increase , he will send us a report soon

but there is something I’m scared of

when my father asked prof Vogl about how are the rest of the body , prof Vogl said, everything is good but there is some water in the belly

my father said : what is it ?
prof Vogl said : its caused by cancer , and its not important to talk about it for now , don’t worry

————

ok what I know is that Ascites is a big problem , why prof Vogl doesn’t feel bad about it ? he didn’t prescribe any medication for it and even he wouldn’t talk about it

is it really not important that much !!!

I feel horrible whenever I hear the word Ascites

Ergin
Member
Ergin

Hi Emad,
Can it be edema?

Ergin
Member
Ergin

Please just becareful and search for it.
I also hate liquid.

Emad
Member
Emad

Hi Ergin

he said water in the belly , which I know is ascites

I was afraid all the time from it , and hear it is

when I read about it , it seemed like it can be eliminated when you shrink cancer

Alex
Member

So good to hear some good news, after so much hardship. But the liquid can be drained right?

Emad
Member
Emad

it can be drained , but it will accumulate again if the underlying cause is still there

draining it multiple times may increase risk of infection

Emad
Member
Emad

how is your dear mother , hope she is good

Alex
Member

Please look for my reply to ergin, sorry i don’t want to be greedy and get all the attention.
I hope you have some better news.
If not, at least we are trying, it;s all we can do.
Reply when you can.

Good Luck,
Alex

Emad
Member
Emad

New Update

Ascites is gone , and there is a good tumor regression

my mother only did TACE + (1.5g Xeloda 2 weeks on 1 week off)

also we still didn’t replace the old blocked port , we are planning to replace it soon

Ergin
Member
Ergin

You are a hero.You always deserve lots good of things.You always choose the right treatments on the exact time.
You also listen Daniel carefuly.
I am waiting for the 2DG news from Daniel without patience 😀.
If it works like phlorizin with same protocol,good and exciting days are waiting for us.

Emad
Member
Emad

Thank you dear Ergin

I wish to collect all these great things , 2DG, phlorizin and the rest

still i have 3bp + sal in the freezer , but waiting for the port to be replaced so I can return again to do my job

I wish a very nice days for you and your entire family

Ergin
Member
Ergin

Hi Emad,
If they are doing IPT without any side effects(which i did without any good responce),
we can do Phlorizin or 2DG therapy with chemo.
And with more efficieny+less side effects.
Just keep it in mind.

Emad
Member
Emad

Thanks Ergin I will be happy to do it whenever its possible 🙂

Ergin
Member
Ergin

When it is resistant ,cancer cells are swimming inside cisplatin lab tray.This is real!

I know a patient which TACE didnt work.
Another patient partially worked.
Thats why we need this website😁

Emad
Member
Emad

Yes that’s right , in our case its partially working

its shrinking the tumor but maybe 10% or little bit more each time

i don’t know how things will end our real fight begins after we end TACE , trying to make things stable with 3bp , sal, phlorizin, 2DG and etc

Alex
Member

So i know this was a while back. But it kinda confirms it to me, being able to access the tumor directly has a great advantage. Being able to deliver drugs and bathe it with them.
Isolation of the tumor from the rest of the body somehow, on it’s own would have great, almost miraculous result in those cases where the cancer type is not very metastatic in nature even without drugs being added into the mix.
So i wonder… would there be a way to clog the “pipes” so that it doesn’t receive fuel anymore from anywhere.
Isolation trough obstruction of blood flow, only at the tumor location.
I theorize that maybe the cancer tumor outputs some chemical that could be more or less unique to it’s “lifestyle”, this chemical could possibly bond with some drug of sorts that would turn viscous and block the capillary vessels right next to the tumor. Blocking all blood flow, leaving the tumor to turn into necrotic stuff. Chemo and surgery to clean it out after that.

As for your latest reply to me.
I’m glad you feel stronger when thinking about me. what can i say… i got muscles i got brains, but i am not all that strong as to make others feel strong, or am i?
I lift my mother daily, with my spine issues, i risk paralysis myself, but there’s nobody else to do what i have to do.
So in the end i am not sure if it’s strength or need, perhaps both, one more than the other.
Am i brave? i have no choice, i wish i had. There are no real choices, those who believe they have choices, it’s those who abandon their loved ones with the illusion of choice, we can not leave our mothers to fate just because of this concept of “choice”, there is none.
My spirit is similar to a terminator’s… i have a mission. indeed i am only human, but the way i feel now, even if i was paralyzed, i would crawl and would bring her water to bed.
As for brains…. i once thought i can cure cancer, i was like… cancer? surely i can solve yet another problem right???
I was so used to solving problems…
So maybe i’m not that smart as i thought and sadly for us, neither is everyone else, maybe by a little yeah.
For us it can seem like a huge gap, but neah… of this i am sure, it’s just an illusion.

To conclude.
Yes cancer is extremely complex and difficult to deal with from so many angles.
TACE seems to me, is one of those things that people did and saw that it was good, and i come back a bit saying, the more closer we get to it, the more we can kill it, or at least make it bleed, and if it bleeds, we can kill it.
Sure not everyone can be saved, but a greater chunk of people will survive, if we find a way…
So i keep thinking, what makes the cancer cell unique? Is there anything about it that the rest of the cells simply don’t have it.

Mom is getting out of clinic in a few days, Doctor is turning her back at me when i try to say anything other than hello.

Stay strong.
Alex

Emad
Member
Emad

Thank you dear Alex, I will be sure to be strong always

I wish both you and your mother enjoy a long living happy life, i wish the same for my self 🙂

you are doing a great job helping your mother all the way, she is lucky to have you

——–

I don’t know what makes cancer cell unique, I believe that once we know that we will solve the puzzle, but I have a mission in my mind, there are so many promising treatments, and many people cannot try them because they are afraid to try, well I can try and I want to try but still a lot of things are blocking me from doing so

I believe I may find a helpful treatment when I try so many of them

———–

regarding isolation of tumor, because of low blood counts looks like prof Vogl suggested to switch to TAE instead of TACE

TAE is only blocking blood supply on tumors with no chemotherapy !

It seems to me a less powerful treatment but with much less side effects

when I read about it, they say that there is no difference between the results of both TAE or TACE , the both have almost the same results !

if Daniel reads my comment I wonder what’s his opinion on TAE compared to TACE

Emad
Member
Emad

Thanks for your respond

do you think it’s right to ask prof Vogl to use something like 3bp instead of just doing TAE ?

Emad
Member
Emad

Hi Daniel

Yes prof Vogl is using Cisplatin with Mitomycin

I asked him about TACE vs TAE, he said that TACE is often more effective

Also asked him :
– how about using something like 2DG or 3-bromopyrovate that may replace chemotherapy ? or you don’t suggest these things ?

He said :
– Thanks yes i worked with bromo
– Too experimental too unpretictable
– Best regards. Tv
– We will work with embolisation material

—————-

I’m happy to hear about doctors willing to do the chemo + 2DG combo for advanced cancers, it’s a good step

I don’t know if the doctors in my country are interested, I should ask some of them first

I will wait until the announcement, then I will see our doctors and what can they do about it

Many thanks Daniel

Emad
Member
Emad

Yes when he answered me I thought you were responding not him 😀

but still I’m not so comfortable with TAE, I once decided to ask him to do 3bp or any other experimental treatment when chemo no longer gives benefit

when we do TACE , the results almost are 10% improvement or a little bit more

but with TAE, could it improve the results by almost 10% ? hard to know

I begin to think about something stupid like liver transplantation

since my mother finished her chemotherapy in 2013, it was almost no disease progression happened except for the liver tumors

its like we are fighting primary liver cancer not breast cancer !!!

its disturbing to think about all these challenges

anyway, I hope things become better somehow soon

Thank you Daniel

Alex
Member

Thank you Emad
So, i’m at least smart i guess…. didn’t know there was a thing called TAE.
Sadly it seems it’s useful in only a few cases. I’m thinking of something for a more general use.
Like in the case of my mother, it’s not a tumor in an organ, it’s on spine, tissues of multiple types. Vessels there are mostly capillary i guess.
So i am thinking of some substance, a polymer of sorts that would block blood flow when it comes in contact with the tumor, maybe because this substance meets with another that only the tumor outputs.
This is only in my imagination of course…..
It’s nice to think about possible solutions,
Should such a treatment be possible in the future, i’m guessing it would have incredible results.
I imagine this polymer would have a certain life in the body, and over time would be excreted trough urine.
Say a one time IV with such a substance would block blood flow at the tumor site effectively for a 12 hour time or maybe even a few days. The result i guess would be massive tumor necrosis. Supporting treatments would be needed and monitoring.

Yet again i say, this is only in my mind… then again so were many other things in the past, they were day dreamers, and after that they became famous.

Or is this yet another situation where i am not aware of some experiment with nano particles and stuff? Might be.

Emad
Member
Emad

I hope the thoughts in your mind becomes reality

yes unfortunately TAE is not useful in your case but, overall prof Vogl offers more than that

Laser-induced thermotherapy (LITT)
Uterine fibroid embolization
Ozone therapy in cases of herniated vertebral disks
PTA, stents, embolization
Radiofrequency tumor ablation
Selective internal radiotherapy with SIR-spheres
Transpulmonary chemoembolization (TPCE)
Transarterial percutaneous chemoembolization (TACE)
Transarterial chemoperfusion (TACP)
Transjugular intrahepatic porto-systemic stent-shunt
Vertebroplasty/osteoplasty

I don’t know which one could help in your situation

and regarding nano particles I think Jcancom is the best who knows about those kind of techniques

ovidiu
Member

@Alex: the idea of strong anti-angiogenesis therapy is no good, there are many articles with the same conclusion, that it makes the surviving cancer cells more aggresive.
I commented on this so others don’t follow this idea right now. Maybe combining such a therapy with HIF-1a inhibitors, and other substances that inhibit cancer cells’ adaptation would work, but this has yet to be proven.

ovidiu
Member

@Daniel: my point was “strong anti-angiogenesis therapy is no good”, not that “anti-angiogenesis is no good”.
If I would have linked many articles where strong anti-angiogenesis led to an increase in cancer aggressiveness and shorter survival, my comment would have been treated as spam…
It’s not just that tumors find other ways (increase secretion of pro-angiogenic factors, switch dependence from VEGF to bFGF or PDGF) but after strong anti-angiogenic therapy (before vasculature normalization) several cancer stem markers get upregulated and stay high.

ovidiu
Member

@Daniel: by “strong anti angiogenesis” I understand what Alex proposed above, to “block blood flow for 12h or more”. This would result in greatly increased hypoxia within the tumor, and subsequent adaptation, by increasing metastatic properties of the surviving cancer cells. Currently, anti-angiogenic therapy works best as an adjuvant to chemo, by normalizing the tumor vasculature, without much increase in hypoxia. If specific hypoxia-activated drugs are available, they could be used to target the resistant cells.

Emad
Member
Emad

Hi ovidiu

you may heard about my mother she will have TAE (bland embolization to block the blood flow on liver tumors)

do you feel like it will make cancer more aggressive after the blood flow returns normal again ?

what kind of supportive treatments you may feel its wise to combine with TAE ?

ovidiu
Member

@Emad: it will make the cancer (the surviving cells) more aggressive BEFORE the blood flow returns to normal, because of the induced hypoxia and answer to it.
In order to get up to date on the matter, I found and am reading several recent articles on anti-angiogenic therapy and hypoxia, I will try to provide a more comprehensive answer later.
Please list here, if you know, what chemo will the TAE involve, so I can understand if it addresses (or not) the hypoxia issue.
I am quoting below from one of the articles I am reading, so you understand that my position is not without base:

Previous studies have shown that resistance to anti-angiogenic therapy is associated with hypoxia-induced alterations, VEGF independent cytokine-driven endothelial growth, mobilization of bone marrow-derived pro-angiogenic hematopoietic cells or endothelial progenitors, and vessel co-option. Anti-angiogenic
therapy inhibits tumor growth effectively by reducing vessel density; however, the subsequent expression of hypoxia-inducible factors (HIFs) and the responsive genes (for example, VEGF, VEGFR, carbonic anhydrase [CA] IX, and CAXII) can lead to therapeutic resistance. In recent years, there has been growing
evidence that hypoxia-triggered overexpression of HIF subunits and the activated downstream pathways play a critical role in resistance to anti-angiogenic therapy.

Emad
Member
Emad

TAE is TACE without using chemo

its just blocking the blood flow on liver tumors with no chemo

prof Vogl used to TACE with Cisplatin and Mitomycin

but because of low blood counts he will not use chemo and will only block the blood flow

I read some articles that suggest anti-angiogenisis with TAE, but TAE it self is a kind of anti-angiogenisis or that how I feel

and more importantly as a last note : my mother may continue to take Capecitabine 1500mg daily (2 weeks on 1 week off)

so its more like blocking the blood flow on the liver tumors, and giving Capecitabine systemically

ovidiu
Member

@Emad: it seems prof Vogl understood the hypoxia issue, since both Cisplatin and Mitomycin are acting stronger under hypoxia. However, they are not hypoxia-activated, like Tirapazamine and Evofosfamide.
Capecitabine is converted into 5FU much better under hypoxic conditions, but 5FU is much less effective under such conditions.
Conventional anti-angiogenesis, like with Bevacizumab, has 3 phases: initial tumoral hypoxia, after 3 – 5 days a vasculature normalization (reduced hypoxia) and then a tumor (unfortunately not only…) vasculature collapse (strong hypoxia).
During TACE or TAE there seems to be no time for a vasculature normalization during the procedure, my guess is that it’s just hypoxia until the end of the procedure.
There are 2 ways to deal with the increase in tumor hypoxia during embolization, to inhibit Hif-1a (and maybe Hif-2 too) and to use hypoxia activated prodrugs.
I am going to list just the Pubmed IDs of the articles, not the full links, so this comment won’t get trashed. The next two are about TACE and hypoxia activated prodrugs, but with primary liver cancer, not mets.

Hypoxia-activated cytotoxic agent tirapazamine enhances hepatic artery ligation-induced killing of liver tumor in HBx transgenic mice.
PMID: 27702890

Preclinical Benefit of Hypoxia-Activated Intra-arterial Therapy with Evofosfamide in Liver Cancer.
©2016 American Association for Cancer Research.
PMID: 27440271

Agents that inhibit Hif-1a are: Albendazole, Shikonin, Silver nanoparticles, Acriflavine (which also inhibits EMT), metronomic (continuous low dose) chemotherapy. And a Multimodal targeting of tumor vasculature looks promising.

HIF-1α- Targeting Acriflavine Provides Long Term Survival and Radiological Tumor Response in Brain Cancer Therapy.
PMID: 29097800

Acriflavine Inhibits Acquired Drug Resistance by Blocking the Epithelial-to-Mesenchymal Transition and the Unfolded Protein Response.
PMID: 27987431

Silver nanoparticles inhibit the function of hypoxia-inducible factor-1 and target genes: insight into the cytotoxicity and antiangiogenesis.
PMID: 27994464

Multimodal targeting of tumor vasculature and cancer stem-like cells in sarcomas with VEGF-A inhibition, HIF-1α inhibition, and hypoxia-activated chemotherapy.
PMID: 27374091

My advice is to talk to prof Vogl about Tirapazamine, Evofosfamide, Acriflavine and Silver nanoparticles, and their possible use in TACE (or just after TACE).

Emad
Member
Emad

Thank you very very much ovidiu for your great information

I will talk to prof Vogl about them and will share his response hear

wish you all the best

Alex
Member

Ovidiu, it’s just my mind wondering… nothing very realistic, i’m talking about an ideal sealant of the tumor trough blocking bloodflow on each and every blood vessel reaching the tumor.
I’m sorry i started this.
I realize that even if it could be done in practice reality is harsh and the cancer will likely come back, however if it could be done, it could prove to be a good solution to extend survival and increase quality of life.
I mean, perhaps being able to shrink a tumor from say, 7cm3 to 1cm3 would be awesome. and maybe some drugs or other therapies could help kill the rest.
Again… only theory….
There is a fotopolymer used to fill dental cavities, it solidifies once exposed to UV rays.
Here it was…. just a thought. Nothing more.
And, while the effects would be very similar if not identical to anti-angiogenesis drug therapies, what i am daydreaming of isn’t actually anti-angiogenic in nature.
It’s a ideal perfect sealant that flows as a liquid but turns viscous and sticky once it reaches the tumor, like latex or something like that, glue….
The situation where i imagine this to be useful is a case where there is no established metastasis and the cancer itself isn’t very metastatic in nature, non small cells things like that.
This daydream would at least reduce the tumor’s volume if not completely cure the person, provided extra measures are taken such as drug therapies etc.

Yes i know… stupid, crazy, useless.
It’s just me rambling, and i apologize.
I was only trying in my mind to imagine some sort of solution to my mom’s disease.
That took me to: How to isolate cancer from the host? question.
Because…. cancer is so complicated, i wanted in my mind to take the more easy approach, and it came to me that isolation of the tumor could be very beneficial, at least on short term, i mean, that’s what surgery is trying to do. To isolate the tumor from the host.
But in my mind i try to find elegant solutions. That’s not to say they would be better.
I’m also challenging myself always because, i still hope i am smart enough, yes i’m naive, but so were many others before me and they got somewhere, maybe there’s more to be done ahead.

Have a great weekend and sorry again to Ovidiu and Daniel.

ovidiu
Member

@Alex: don’t be sorry for mentioning this, I had a similar idea years ago, but after reading stuff, I decided it’s risky. The response to anti-angiogenic therapy varies from one kind of cancer to another and probably between patients too, so no one can tell for sure the outcome.
Even if you’d shrink a tumor from 7 to 1 cm3, if the remaining cancer cells are much more resistant, then the long term outcome is worse.
If there were an anti-angiogenic therapy that would kill 100% of the cells within a tumor, then it would be successful on it’s own, but this hasn’t happened yet.
Something like an impermeable “skin” around the tumor, including some peritumoral tissue where CSCs could be found, now that could kill 100% of the cells within, but it’s not available afaik.

You don’t have to apologize, I apologize if I made you uncomfortable, it wasn’t my intention.

Ergin
Member
Ergin

Yes Alex,
There is a way to kill cancer cells and not healthy cells.
Hyperthermia,if used wisely and you
already know the protocol.
We have to trust the articles.Or we must wait for years for a doctor to try it again .Make it an article and wait for another lots of years.

Alex
Member

Brother,
We are back from clinic… after 2 weeks….
Tomorrow i have more papers and things like that to deal with, getting the oxigen aparatus
For now she is better, but still paralysis on left arm and right one weakened. But compared to first day, much better.

More information in the coming days.

PS, take care of yourself.
Alex

Emad
Member
Emad

Ascites is back again

the reason is unclear

last TACE session was less than 1 month ago, I can’t imagine that cancer could do anything in this short time under TACE effect !

but this is how things started

last week my mother started to feel weak quickly and suddenly , and she was under Xeloda

3 days ago she felt even weaker, I told my family that she must do CBC immediately

she did CBC and just as I expected, it was bad

HB was 6.5
RBC was 1.5

the others are very low too

severe anemia , I think it’s the reason why she is weak, so we decided to do blood transfusion, 3 units

2 days before she took 1 unit, she felt a little bit better but still she feels weak and the symptoms of anemia are still there

yesterday she started to complain about her stomach, it is distended and it’s doing some pressure on her

today she will take another unit , and next Saturday she will take the third unit

but why ascites ?!

in my opinion, I think severe anemia did increase pressure and making the organs weaker, and the liver was affected and become weaker due to severe anemia which again caused ascites

I hope i’m right, but also maybe i’m just lying on my self

Alex
Member

I’m no doctor, nor will i ever be… but what about the immune system? Could be just a stupid question.

Emad
Member
Emad

I think you mean more than just WBC’s right ?

for WBC’s they are low , but I think you mean immune system in general , but I don’t know if it’s linked to ascites ?!

Ergin
Member
Ergin

Hi Emad,sorry to hear this ascite again.
Do you have more DCA at home?
Lest ask it to Daniel if it helps ascites or not!
But we dont know what is the cause,liver or tumor?

Emad
Member
Emad

I have but my mother hate it because of neuropathy

but I hope cancer is not the cause this time

Emad
Member
Emad

Holy God, after days of searching and trying to find donors with AB+ type

after we got 2 donors , we went to hospital at late night to do blood transfusion with those 2 units

but we found nothing !!!

the freaking hospital just rob those 2 units at the end and left us like we are nothing !!!

no comment

Alex
Member

So sad to hear this.
I wish i was there so i could donate. i’m not sure but maybe i have the same blood type.
I heard another story like that here, a guy asked his friend to donate for his father, when he went to get the blood, the person who collected the blood had already sold it for a few hundred euro.

I think the immune system has something to do with ascites. Inflamation and maybe more than that.

let me know
alex

Emad
Member
Emad

Hi Alex, I hope your mother is good

thank you for your concern, when I was with my mother in the hospital I felt sad and weak, but when I thought about you I felt stronger 🙂

Yes it made us angry

tonight my mother did blood transfusion, 2 units

yesterday she got 1 unit

she feels better, but also she didn’t complain about her stomach anymore !

I hope it’s gone again

and yes I believe inflammation has important role with ascites, CRP needs to be measured

wish you all the best my friend

Shanti
Member
Shanti

Hi Emad, I was also very sad to read this, I can only imagine your frustration and wish I could help. I hope that things have improved for you since you wrote this post.

Emad
Member
Emad

Thank you very much Shanti

yes it was frustrating to all our family and friends

and yes like you said, things become better now and my mother did blood transfusion after we found other donors

Kind regards
Emad

marcosbomber901
Member

Hello Emad
I’m glad that your mother go to improve little by little you are a warrior against the cancer. How can I contact the professor Vogl,has the mail from the hospital where he works or clinic?

Emad
Member
Emad

Thank you so much marcos

this is the email address that we use to contact prof Vogl

T.Vogl (at) em.uni-frankfurt.de

he is working in Frankfurt hospital

let me know if I can help you with anything

marciomega
Member
marciomega

Hello Emad
It´s been some months since I joined this group and my situation is very similar to yours and many here. Both my parents have breast and prostate advanced cancers and all my spare time goes to researching and trying to help them with as much information as I can get.
Recently i have been researching on hormonal treatments options for deseases that after some time became resistant to it. In the last 5 years articles on Androgen receptor´s role on some cancers lines have been constatly growing and there are some trials going on. There are even some doctors in US who are already implementing testosterone and testosterone antagonists in their treatments, despite the fact that they are not still ” well stablished”.
Have you , Daniel or someone else, ever read something about this? Since your mother has hormone sensitive breast cancer, returning to hormonal treatment could be an option. I´m seriously considering this for my mother : Xeloda+ supraphysiological testosterone dose+ aromatase inhibitor.

Emad
Member
Emad

For the third time ascites is happening again

it happens almost immediately after blood transfusion

2 weeks ago it happened after 24 hours after 1 unit blood transfusion

and I gave my mother small dose of diuretics for only 1 day, and things went fine for the entire week

after that (4 days ago) my mother did receive 3 units of blood

and after less than 24 hours her abdomen distended and become bothering her

I gave her diuretics and she felt good again for 2 days , but today again she feels some distention

I really don’t know whats going on, if the cancer is responsible for this, how come can cancer do progress this quickly in a short time after a very good TACE result !

things are very very weird and disturbing me so much

Emad
Member
Emad

Update :-

Good improvement in general, there is no ascites

the abdominal distention maybe some side effects but it has nothing to do with the liver

prof Vogl did TACE and not TAE, but this time he used just one chemo drug (Irinotecan)

he didn’t use Cisplatin or Mitomycin because of very low platelets

Emad
Member
Emad

Bad news for me

2 weeks ago my mother start to feel very weak and tired, with pain all over her body

we thought its something that happens temporarily and go away soon

but with no improvements we decided to do blood test for CBC and kidney functions

(( we didn’t do Liver functions test because we already expect to see abnormal levels ))

hear is the result :-

CBC :-
WBC : 9.4 (very good)
HB : 10.5 (ok)
Platelets : 22 (bad but its better than before)

Kidney functions :-
Na + K are normal
Creatinine : 1.7 (normal level is 0.5 – 1.5)
Urea : 138 ( normal level is 10 – 50)

UREA

why its increased to such level ! is it late for us to fix this problem?

It will be very tough for us to end up fight with both liver and kidney problems

please if there are any information to help us in this situation I will greatly appreciate it

Emad
Member
Emad

I just returned back from the hospital

my mother admitted yesterday in the morning, she developed high fever today, they are giving her paracetamol with flagyl (antibiotic)

for the kidney issues they are managing it successfully with Dextrose or NaCl (hydration)

but for the liver and jaundice :

most of the doctors suspect obstructive jaundice, few of them suggest liver damage

and because they saw multiple lesions on the liver they said : probably tumor is the cause of obstruction

CT Scan didn’t show any clear issue, we may do mrcp to get better answer

also one of the doctors wondered about the huge drop of HB level from 10.5 to 6.6 in less than a week , and maybe its causing high bilirubin !

we have more questions than answers, poor hospitals they are costing us thousands with no real answers

they are treating my mom like she is dying from cancer, they are giving her tramadol

we contracted prof Vogl, he said that he is sure that cancer is not blocking anything, and there is other causes with some inflammation, he said that doctors should give my mother dexamethazone to reduce inflammation, also try to find the real cause with proper scanning

———-

the situation is mixed, too many suggestions, and the only loser is my poor mom

please pray for her to recover soon

Sincerely
Emad

ovidiu
Member

@Emad: some observations on current situation and treatment (trying to cover various possibilities):
– Flagyl is Metronidazole, useful against many anerobic bacteria (like Clostridium) and amoebas, but not broad spectrum, and damages the liver; if the suspected infection in the liver / gallbladder / biliary tract is currently caused by an anaerobic bacterium or amoeba, then it should help; but there is another possibility, that a biofilm producing bacteria, sensitive to Ciprofloxacin when planktonic, survived in biofilm form, especially if gallbladder stones are present (they could have same density as bile and not show up on CT); in such a case, one of the Carbapenems or Teicoplanin would be IMO recommended, Metronidazole won’t help at all;
– if prof Vogl said he is sure cancer is not blocking anything, then probably the metastases were not close to the bile ducts (in the liver); if some lesions in the liver are close to the bile ducts, they could be necrotic spots caused by the bile accumulation; in other cases, other than cancer, they could be liver abscesses by a pathogen;
– I suggest again to ask for cytologic blood smear, when doing the next blood tests, just to rule out a systemic infection, that temporarily responded to Cipro; it is possible that in a blood transfusion received by your mother there was some pathogen, that flared because of the immune suppression by Irinotecan.

Emad
Member
Emad

Dear all

Today here in Tunisia my dear mother Nawara Mansour passed away peacefully

She left us and left her 3 little daughters Maria, Maysem and Mera

may her soul bring peace to our lives

ovidiu
Member

@Emad: I am very sorry for your loss.

Emad
Member
Emad

Thank you so much for your great support dear ovidiu

Pouya
Member

We all lost another family member Emad. my deepest condolences brother.

Emad
Member
Emad

We faced the same destiny, and we will live in this same horrible life, thank you always for being with me all this time

Shanti
Member
Shanti

Dear Emad- I am so sorry for your loss. You and your family and mother are in my thoughts and prayers. May healing come and love prevail.

Jcancom
Member

Emad, my deepest condolences.

You have done such an extraordinary job through all these months and years.
You seemed to be bending time until I thought that you had suspended it.

Your journey that you have documented so well on this forum will be a resource for others
who will have to walk in your footsteps. You have set a very high standard for others to try to match.
I hope that the comments and friendships from this forum helped lighten your load as you traveled a difficult
path.

Very Dear Best Wishes, J

marcosbomber901
Member

Emad sorry for your loss,my pain is your pain,you have done the best job possible.Your mother feels the immense love of his son up there in the sky

stefanjoita@yahoo.com
Member

Condoleante Emad.Cuvintele sunt neputincioase in fata durerii tale.Stiu cat de reponsabil esti si fii puternic,slujeste-o in continuare pe mama ta draga tie protejand cele trei surori pe care le-a lasat in grija ta.
Regrete,Stefan

Emad
Member
Emad

Mulțumesc dragă stefan pentru cuvintele voastre bune

Emad
Member
Emad

Thank you dear marcos

Emad
Member
Emad

You always supported me with your knowledge, I was about to prepare my self to use all the strategies you discussed here in this blog

but even when cancer was shrinking, the liver become weaker, and with bacterial infection, my dear mother ended up with septic shock and fulminant hepatic failure

my fight with cancer will never end, and I will try to help people with the knowledge you gave me as much as I can

Thank you very much

Emad
Member
Emad

Thank you always Daniel

Sorry for my late response, I was busy in the past days, friends and relatives were in our house coming and going all the time, just today we are alone again

I so much understand now when you said that you are trying to keep yourself busy, It’s very hard to stay alone with your bad feelings

This is life, we are not the first who lost a mother, and unfortunately we are not the last

I also believe that this life is just a small step, and we will meet our loved ones after that

I feel I want to take some rest far from cancer’s world, but just for a short time, here in Libya I can’t take any long rest, cancer is spreading everywhere and people are always suffering

I need to somehow convince the doctors here to try new strategies, new protocols, especially for stage 4 cancer patients, its sad to see people dying easily without any hope and missing the chance to use new treatments

I may ask your help with that

I will not feel better until I see people get benefit from treatments other than chemo

And I will not let my mother’s life go away without any value, I will fight cancer until the very end

I will be in touch, always wish the best for you my dear friend

Emad
Member
Emad

Thank you Shanti, we need your prayers

Emad
Member
Emad

Thank you dear Shanti, and sorry for my late respond

take care, I wish the best to you always

Ergin
Member
Ergin

Deepest condolences my brother Emad.:(((((((((

Emad
Member
Emad

Dear brother, you are special, all my family are thankful for your continues help, our mothers will remain alive in our hearts

Ergin
Member
Ergin

Emad thank you for being my brother forever.

sirsna
Member

Emad,
Your fight for Your dear mother’s health was very strong! You are a hero!
My deepest condolences to Your Family and especially Your little sisters!
i.

Emad
Member
Emad

Thank you dear sirsna

My prayers for you to live a healthy long life happy with your family

Alex
Member

Emad, i am trully sorry for your loss.
This news i read only now, after so long.
I am not a good word’s person, but i can tell you i can only imagine the horrible ways you must feel now.
You were a big motivation for me and most likely others to come here and read about possible solutions.
But i am sure that the cures were not of much help.

Like Ergin said, people live longer who come here.
But i have something to say about that.
People who come here don’t live longer because of some substance but because of LOVE.

I know how much you love your mother, i know how much Ergin loves his mother and father.
This is why i know that when someone like that passes away, words are useless. Or so i felt and feel.

So i say to you what i said to Ergin. Go relax… take a vacation, focus on you now. All our mothers would have wanted the best for us.

However, i appeal to Daniel for a RIP page, where the passed away may be remembered and noted by everyone.

I feel my time with my mother is coming closer and closer. I don’t know….

Please take care of yourself now.
Alex

Ergin
Member
Ergin

Hi Alex,
I am truly sad about your message.
You know who i m.

marciomega
Member
marciomega

Hello Emad, I don´t Interact so often on the board , but I correlate so much with your story cause both my parents are fighting câncer and my life in the last years has been fighting with them , just like you fought for your mom. I was so much wishingshe could oovercome all that….I´m truly sad to know that and I hope you find strengh to live again …without the weight of cancer and all the suffering it brings….I´m very very sorry for this loss…

Emad
Member
Emad

Thank you dear marciomega

I’m very sorry to hear about your challenge, its tough

From the bottom of my heart I wish you see your both parents got cured from this disease, I will pray for you

take care