Your Contribution Needed on Breast Cancer Story from Emad

Dear Friends,

On the same line as the post from Ergin, https://www.cancertreatmentsresearch.com/your-contribution-needed-on-ovarian-cancer-story-from-ergin/ I would like to invite you if you could please share here ideas and experience that may be relevant to Emad and his dear mom.

Off course, as the disclaimer is also stating, this website is not intended to offer medical advice but to try and get together as much collective knowledge as possible, so that finally, together with our medical doctor we make informed and successful decisions regarding our treatment strategies.

Here is the message from Emad:

 

Dear all , my name is Emad Abushofa , from Libya

In 2012 my mother diagnosed with metastatic breast cancer , Estrogen positive , Her2 negative

Tumor marker was about 500, she was walking hard because of mets in her legs

After 9 cycles of chemo then radiotherapy , the tumor marker declined to 30 , and she became able to walk normally again

Then she started on hormonal therapy , but the markers were raising slowly

Until August  2015 , the tumor marker became 2000 , so decided to return to chemo

She took  6 cycles of taxotere ( also I added DCA + Natural protocols like Budwig , MSM LIPH , Juicing , Liposomal Vit C)

The tumor marker declined from 2000 to 353

After another 3 cycles , but this time only chemo , the marker rised to 712

Then the oncologist changed the chemo to 5FU and venorelbine , 2 cycles with DCA , the tumor marker declined to 450

Then I stopped DCA few days and didn’t give it before chemo , the marker rised to 558

Then again DCA with chemo + artimisnin + baicaline , decline to 450

Then I run out of everything , marker rised to 714

Changed the chemo to Gemzar + Carboplatin , 3 weeks per cycle

Cycle 1 : chemo alone , decline from 714 to 685

Cycle 2 : chemo then DCA IV added lately (not before chemo) , raise to 699

Cycle 3 : chemo + DCA IV , decline to 517

Cycle 4 : chemo + DCA IV + one shot half dose Salinomycin base version , decline to 408

Cycle 5 : chemo + DCA IV + one shot full dose Salinomycin base version , decline to 317

Then we stopped 2 weeks because of blood transfusion , also runout of Sal

Cycle 6 : 2 weeks DCA IV only, then half dose chemo with DCA IV , raise to 380

Cycle 7 : chemo + DCA IV , decline to 350

Cycle 8 : chemo + DCA IV + 3 shots Salinomycin sodium salt version , decline to 330

Cycle 9 : chemo + DCA IV + 4 shots Salinomycin sodium salt , decline to 320

Then another stop for 2 weeks because of blood transfusion (DCA IV  + one shot Sal)

Cycle 10 : 75% chemo , DCA IV + procaine IV + high dose lansoprazol + 1 shot Salinomycin sodium salt in the same day of chemo

Tumor marker raised from 322 to 607

 

Few notes :-

1-     I started to give procaine IV just 2 weeks ago , 2ml of 2% solution , half an our before DCA IV

2-     My mother always had a marked tremor when using Sal , sometimes strong

3-     First 3 days of chemo I give my mother 180mg lansoprazole per day , then 80mg for other 4 days

4-     The mets on my mothers bones are small and stable for along time , but the mets in her liver are trying to grow fast , 5 spots less than 1cm , 3 spots between 1cm to 2cm

5-     Im not sure about the last chemo cycle, we felt like they didn’t give my mother the proper dose

Now I only have DCA + procaine, I have 100ml MethylGlyoxal , no more Sal

 

I will be happy to listen from you , your opinions will always help us

Thank you so much

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Alex
Member

Dear Emad,
With all respect, i know you’ve been here much longer than me.
Where is Metformin? If you didn’t use it…….. it’s good stuff.
Any special reason for not including it or is it something you forgot to mention?

Best wishes,
Alex

Emad
Member
Emad

I used it for a while , maybe for 2 months

I didn’t notice any change with it

quote :
——————————
Then the oncologist changed the chemo to 5FU and venorelbine , 2 cycles with DCA , the tumor marker declined to 450
Then I stopped DCA few days and didn’t give it before chemo , the marker rised to 558
———————————

the 2 results above I was using metformin with it , also some others like chloroquine

maybe I will give it another try this time

my best wishes for you too dear Alex

Alex
Member

I find that 26.mg/kg/day is necessary, what was the dose used by you?
Also metformin is greatly amplified anti-cancer when combined with aspirin or diclofenac or maybe even citric acid.
https://www.ncbi.nlm.nih.gov/pubmed/26056043
Mebendazole would also be a great addition to those, still unaware of what the best dosage would be.
If you are asking what the effects are, i cried tears of joy today, seeing how my mother is feeling better. No marker number.
We are also using HCA, CA, ALA.
If you feel something is out of place, i would go check blood, hormones, glands, they do play a big role, and no chemo will be able to help much so long things are out of balance. (So i feel).
Don’t forget the liver, immune system, the gut. I hope your mother has been doing coffee enemas too, and going on a vegan diet
IT HELPS!!! Every bit of good food counts, and every bit of bad food is very bad.
Also, i would also check the dental situation, there is data out there pointing to breast cancer and major hidden tooth issues.
Thermografic imaging….!?
If the tumor is within “reach” consider heating the breast, free hyperthermia?!?!? 50C-60C hot water, steam. Eh?

Congrats on getting so far with your mother.
Best wishes.
Alex

Emad
Member
Emad

I used 1g metformin only , with the dose you mentioned , it means I should use 2g daily

no coffee enemas unfortunately

you are totally right about the good food and bad food , they are really a major role in all this

there is no hyperthermia available here in our country but if my mother had the chance to be treated outside Libya , hyperthermia will be a good choice indeed

but after all I’m happy to see you happy man , nothing is better than staying healthy in this life 🙂

take care my friend Alex

best wishes

Alex
Member
Emad
Member
Emad

yes they are really interesting , I have watched all the episodes of The Truth About Cancer

sad we missed the chance to correct my mothers body when she was on hormonal therapy for 2 years

now after she heavily treated with chemo it become very hard , but still not something impossible

Alex
Member

I am curious what you would change if you had the chance to go back in time?
i know i would reconsider suggesting surgery, it proved to be a mistake, solved nothing. Anyway….

Emad
Member
Emad

sad that we can’t change the time

if I started to search alternatives since 2013 , probably I will go totally natural with my mother , treating the underling cause , correcting the body chemistry

now after we started chemo since 1.5 year , it begins to be so hard to do what we should do , cancer is more aggressive , and our country economic problems become disaster

Meech
Member

If I were to guess, I’d say that the tumour marker rising that much during the last cycle could be due to taking a rest from chemo for the blood transfusion.

ie. Maybe the tumour marker raised even higher during the rest, but still did fall to 607 with the chemo. So what looks to be a case of chemo stopping working might not necessarily be the case.

At any rate, even if this were the case, this tumour looks incredibly aggressive. I would look into some off label medication.

Like Daniel had told me earlier, Diclofenac might seriously potentiate the effect of DCA by downregulating MCT1 (I believe) and up regulating SMCT1.

Daniel also spoke of inhibiting autophagy during chemo so as to take one escape route away from cancer cells which would normally temporarily protect them during stresses like the ones created through chemotherapy.

I think I would keep the proton pump inhibitor that she is taking. I’ve read that it potentiates many forms of chemo.

Emad
Member
Emad

Hi Meech

thank you so much for your notice

we did blood transfusion before and also the chemo delayed same as the last time and even they give carboplatin only with no Gemzar , but tumor marker only raised from 317 to 380

but the last time is totally different , I think like Daniel said , PPI are not a good choice with weak acids , this can describe what happen

but really my mothers cancer is aggressive , and I can notice how its getting more and more aggressive every time , and I should blame chemo for that

but in your regarding off label medications , I’m a little bit scared from using them too much , I don’t want to put more stress on the liver and kidneys

diclofenac , metformin , chloroquine and others , I may give them another try

this nearly used 25 chemo cycles , my mother is 50 years old , I hope she can tolerate it , she can live with chemo as she is not feeling weak or tired , but her bone marrow and other organs I’m not sure if they can stay good for long time

my best wishes to you Meech

Meech
Member

From what I’ve found online, Metformin’s nephrotoxicity can be attributed to its increasing risk of lactic acidosis. However, risk of lactic acidosis is incredibly rare (around 3-5 people per 100,000). It’s also important to note that the vast majority of patients receiving Metformin are also diabetic, which would indicate probably some deal of kidney damage in the first place due to high prevalence of obesity, hypertension, etc. With this patient group.

So I don’t want to go out and say “Metformin is fine to take and low risk” because I’m not an expert, but I think checking out exactly what the risk of kidney damage is with Metformin would be beneficial as it is a pretty valuable drug.

I do understand the concern though. I only have one kidney so I also have to exercise a lot of caution with medications.

Wishing all the best,
Meech

Emad
Member
Emad

metformin should be safe compared to most of the drugs , and really I believe I should return to use it again

sorry to hear that you have one kidney Meech

you are inspiring to all of us on the way how you are living and taking care of your self 🙂

Meech
Member

Thanks for the words Emad. Hope the new treatment strategy works out; make sure she’s drinking a ton of water daily with all of these things she might be taking.

Emad
Member
Emad

Thank you so much meech

Ergin
Member
Ergin

Hi Emad,
I felt that one day you will write those words.The rise in markers.Because it was stable.
If you use salinomycin,it should be easy for you to use phlorizin or derivatives just before chemo.
You must also read T4 depletion,for me it is one of the best in our hand for now.
There is a serious and very good responce on breast ca.Please read it.
I always find your comments in all treatments like chloroquine or mebendazole diclofenac.Where did they gone?
Did you stop them?Or forget to write to your above post?
You never used any angionegenis inhibitor as i see.
You are not in a situation that words stopped.
We will never give up.You are very strong,dont forget your words in our communications.
Kind Regards
Your brother who will always near you.

Emad
Member
Emad

Thank you always for your kind words and great help to our family Dear Ergin

believe me I felt strong for the first time yesterday when I was waiting to receive the results

I used to feel sick everyday when it comes to marker results

I remembered how strong you have been to face the results each time 🙂

regarding phlorizin is there any good source you know about ? or its only available in chemical companies ?

T4 depletion is one of my choices , i will study it more and be ready to use it

regarding chloroquine , mebendazol and metformin , i used them with some others , but i didn’t notice any deference , but also i didn’t give them more than a month or 2

one of things that let me stop them is to not do more stress on the body , but maybe I’m wrong and my mother can easily tolerate them all

i feel i must give them a serious try again

and for angionegenis , i will look if i can have the cheap version of Thalidomide

so much strategies , i need to think carefully for my next step , just like you brother , hope we find the key soon

and i believe that we both could find it

like John Cena said : never give up 🙂

Wondering
Guest
Wondering

Hi emad

The more i read about metformin the mire convinced i am its a must

It affects both mito and nucleus, glucose level, igf…

Im taking berberine insteaf of metformin, similar impact

W

Wondering
Guest
Wondering

no worries, Daniel, i know you are not a robot capable of answering dozens of comments each day 🙂
in the meantime i found your post regarding cachexia. i did not read it earlier as im not affected by cachexia – but i realised that you wrote a lot about about glutamin uptake inhibition and provided lots of hints again.

in my comment to to you (and all) earlier i was a bit shocked that 3 studies claim that more energy is produced by the mitochondria in cancer cells than by the nucleus against the conventional wisdom. It is in contradiction with the the opinion on glyculisis of Seyfried, Swartz etc.. who claim that mitochondria is dysfunctional and more atp is produced by glycolisis. Probably the key in is in effectivity (36 vs 2, mitochondria vs glycolisis, so if nucles is used 90% of the time, mito is still producing more atp). But then we can not claim that :
1) restoring mito will help – ) as it works already… against human survival
2) blocking glycolisis will kill cancer
3) Warburg was right

there is MUCH confusion about this topic even among scientists..

cheers
W

Helga
Member

Hi W,

good logic. However, blocking glycolysis is a good strategy for sure even if we don’t know the full picture why. Yeah, mitochondria could be functional in cancer cells but we know that glycolysis suppresses the immune system, therefore it is advantageous to suppress it, even if for no other reason. Best strategy is to rely on experiences, rather than theories if we can choose between the two. And you are right, people are confused about the Warburg effect, etc. incl. scientists.

cheers,
Helga

Helga
Member

Wondering, you might be interested in this.

More on metabolic issues in cancer. I found an article discussing these and Warburg, etc. E.g. Have you heard of oncometabolites? They argue that some of the metabolites produced by the cancer cell are actually oncogenic! Boggling the mind.

“With this broadened view of what constitutes an oncometabolite, one could argue that the discoveries of two other oncometabolites, succinate and fumarate, preceded that of 2HG.” Here is the paper: http://www.sciencedirect.com/science/article/pii/S1535610812000785

Fumarate? Could it be that dimethyl-fumarate, the anti-psoriasis drug, ( here: https://www.cancertreatmentsresearch.com/anti-psoriasis-drug-works-against-tumors/ ) competitively inhibits fumarate?

Wondering
Guest
Wondering

thanks Helga, i started reading the sciencedirect article!

Wondering
Guest
Wondering

best summary on this topic i ever read…clear..and balanced.

Wondering
Guest
Wondering

Sure, you are obviously right. I find it though confusing that many scientists on the “metabolic” side keep telling how unfunctioning the mito is, while it is producing mire atp according to several studies now. Cheers, w

Wondering
Guest
Wondering

another nice article mentioning another fuel for cancer..cellular signals. crazy. Still i believe blocking glutamine and cancer must lead to apoptosis in a wide range of cancer.

http://blog.dansplan.com/starving-cancer-of-glucose-and-glutamine/

“Glucose is not the only driver of cancer cell growth. Certain forms of cancers have also been shown to rely heavily upon glutamine as a source of fuel. Cancer cells have evolved a number of different ways of acquiring the amino acid from host tissues. In fact, it appears that cancer cells may derive energy by literally consuming cellular signals. Zhao and colleagues came upon this discovery when investigating the role of exosomes, which are tiny pouches of proteins and nucleic acids that transmit information between cells. The team was surprised to find that not only were the cancer cells receiving these signals from other cells, they were using them as a source of energy, consuming amino acids directly from the exosomes. This is another example of how remarkably resourceful cancer cells can be – drawing in glucose and amino acids from the environment as building blocks for tumors.”

Helga
Member
Helga
Member

Phlorizin is found mostly in apples (skin) but also in Mexican oregano (dried): http://phenol-explorer.eu/contents/polyphenol/109

Wondering
Guest
Wondering

thanks Helga.
I was thinking about adding something like this but Daniel wrote that with oral administration much of it leaves the the body in stool …so probably not too effective if not via intravenous way. pity.

Emad
Member
Emad

like curcumin , no chance for oral unfortunately

Helga
Member

I take turmeric with 10% black pepper and add also dry ginger. I dissolve all of them in soda water (or fizzy mineral water). I swear to you I can feel the effect. However, mostly probably against inflammation as I have not been diagnosed as having cancer (finally found a gynecologist here, who will examine me in early June – I wonder what women do here if they need one urgently, e.g. pregnant? one would think that you’d have to wait 3 months for an exam in some 3rd world country but they might have actually a better care than this particular little country in the EU, damn).

PaulF
Member

Helga

Sorry to hear of your situation. What country do you live in?

I find the black pepper really helps with the absorption of Tumeric and Curcumin. I have not thought of adding dry ginger, that would really help in my opinion.

Paul

Helga
Member

Dear Paul,

it is a small country in Europe, overrun by the Soviets in 1968. It is fine but maybe there is a shortage of gynecologists/doctors here or perhaps too many women live in this city. It is a rather Kafkaesque situation 🙂

I am glad you find turmeric/black pepper also useful. I think that carbonic acid (in the soda water) also helps with the absorption. And ginger has a great anticancer effect in itself. It is worthwhile to combine it with citric acid. My bump in my belly greatly diminished since I am taking CA. Perhaps Ergin is right and it is not ovarian cancer after all. Nevertheless, I still have a lot of sweating. My other ‘candidate’ is my right lung, which produces a lot of mucus. An X-ray didn’t show a mass. Does anyone know what % of lung cancer can be seen in an X-ray?

How is your sister? She has lung cancer if I am not mistaken, right?

Kind regards,
Helga

Alex
Member

X ray,
LOL,
Dear Helga.
When the doctors looked at my mother’s xrays they couldn’t see a thing…… not one.
Scanner showed the tumor very very clear.
Bone will show contrast, for a tumor to be more than transparent, it will have to be calcified.
The shape may look like something else, not a ball of tissue but some claw shape… etc etc.
Next to that shape you would have the soft tissues that are for the most part, transparent to xray

Many Thanks,
Alex

Ergin
Member
Ergin

Hi Emad,
I wrote a message but gone.But not important,you know my feelings about you and your mother brother.
Please read this link.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268104/

Ergin
Member
Ergin

This is a summary table in that page.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4268104/table/tableA1/
They use cimetidine in all.I am sure Daniel will talk about this.

Alex
Member

Ergin, brother.
Still did not received that package from you yet.
How is your mother? How are you? You are online on skype but…. no answer.
Interestingly mother is feeling better with no DCA maybe the other things are doing very good for her.
Today she feels very good. More mobility, less inflamation.
I also add 100mg Mebendazole X3
And i alternate aspirin with diclofenac from day to day.

Cheers.
Alex

Ergin
Member
Ergin

Hi Alex,
I hope it is not in the customs.I will send you the tracking number tomorrow.
Skype is open in office i think.
After my mother began mebendazole,diclofenac,celecoxib etc., her pain on bowel released.
May be it is because of the pain killer effect of them.Or they helped,i dont know.
Cheers
Ergin

Alex
Member

Ergin.
Today i cry tears of joy, seeing my mother feel better, i reminded myself of all the help i received.
It was a very nice day here for us, a rare event in my life… me crying tears of joy. Thank you!!! Daniel, everyone here.
don’t give up metformin bro, it helps very much. Vegan diet, no bread, oil, fat, very little fish 1/week same for egg.
Diet helps with bowel problems too. and enema.
Don’t forget the immune system.
1 fruit before food helps with bowel problems too.
Don’t forget water, good hydration

Best wishes,
Alex

Alex
Member

i can tell you what released pain in my opinion.
It was celecoxib because it stops COX, (fermentation) for aprox 4 hours. – Similar to aspirin.
http://cancergrace.org/cancer-treatments/files/2012/04/ASPIRIN-biology.jpg

Alex
Member

i am sure celecoxib is sinergistic with metformin

Emad
Member
Emad

yes cimetidine is also good and looks helpful , and can be found easily 🙂

Wondering
Guest
Wondering

hi Ergin,
thanks – i have heard about cimetidine from you and Daniel and i already bought some. it seems to have several anti cancer properties.
@All,

Havent you think about random pills having much anti cancer effect? there are reports showing that antibacterial pills, anti histamine pills, anti inflammation pills anti worm pill, anti malaria, blood pressure reducer pills, anti diabetes pills anti malaria pills, even anti acne pills have anti cancer properties. Maybe one with cancer should take ALL what she can bear from above pills and the result would be surprising, a real anti cancer cocktail. There would be more synergy than negative interference. I mean it. And if you think of the brian cancer cocktails, for instance the one of Brian Williams – that pretty much relies on boring pills like anti acne pills. probably its beacuse cancer is the disease of the diseases – it uses any method it can grasp – and it can mimick some other conditions hence…. and pills curing those other conditions can be therefore effective.

ovidiu
Member

I would try metronomic chemotherapy plus lansoprazole or omeprazole, metronomic vinorelbine seems well tolerated, maybe add celecoxib.
But for the liver mets this may be not enough, the standard palliative choice for liver mets is radiofrequency ablation.

Ergin
Member
Ergin

Hi Ovidiu,After learning this tech.from Daniel again,i am searching for cyroablation.
It looks better than RFA.
Does anybody has experience about it?
Because there is no bleeding after cold ablation in -40 centigrate,tumor seeding will be very low.
I like it very much but you can not use it on everywhere,like bowel.Necrosis is dangerous on some organs.

Alex
Member
Emad
Member
Emad

Hi Ovidiu

I’m always reading your comments , I’m learning things from you each time , your opinions will indeed help 🙂

i wish that we did metronomic chemo from the first days , before cancer become more aggressive

regarding celecoxib , (as a medical student) they used to teach us that celecoxib may damage the heart ?!

but some doctors don’t believe on this , what do you think about it ?

ovidiu
Member

@Emad: you don’t have to use a high dose of celecoxib, and only use if the metronomic chemotherapy induces Nfkb (like etoposide and cyclophosphamide do, I don’t know about vinorelbine).

Other observations: the blood transfusions can contribute to chemo-resistance, that’s from my personal experience, after such a transfusion what previously worked (although barely) stopped working (CEA rose as without treatment). I believe that the blood may come from people who do this blood-giving for a living and their blood contains extra growth factors, which can increase angiogenesis and chemo-resistance.
Gemcitabine is responsible for the low erythrocytes and platelets, and the oncologist may prescribe erythropoietin, and this would be a big mistake. It makes cancer cells more metastatic and chemo-resistant.
Erythropoietin activates cell survival pathways in breast cancer stem-like cells to protect them from chemotherapy.
https://www.ncbi.nlm.nih.gov/pubmed/24008319
Erythropoietin and drug resistance in breast and ovarian cancers
https://www.ncbi.nlm.nih.gov/pubmed/27321103
Erythropoietin promotes breast tumorigenesis through tumor-initiating cell self-renewal.
https://www.ncbi.nlm.nih.gov/pubmed/24435044
In my father’s case, after Erythropoietin the Gemcitabine + Curcumin + Metformin + Disulfiram that kind of worked stopped working. The oncologist believed it was only resistance to Gemcitabine, but it was worse.

Emad
Member
Emad

oh my !

That’s horrible , its too scary I feel like I’m loosing it >_<

it really looks like blood transfusion is doing something wrong here as things started to change after the first transfusion !

or maybe its for another reason we don't know about

we still didn't use Erythropoietin , I hope not to use it , but receiving blood is something we can't runaway from

chemo will continue lowering the blood counts and we will need more blood each time , without blood we can't continue on chemo and we still far away from having another alternative

its like a closed circle

this is terrible

but really Ovidiu how do you think is the best way to protect from making cancer more aggressive after receiving blood ?

i hope dear Daniel give us his opinion on this

ovidiu
Member

I didn’t say that the cancer would become more aggressive after a blood transfusion, but after Erythropoietin. Growth factors in the blood would probably return to normal levels after a while, but IMO it’s likely that chemo won’t work soon after a transfusion.

There is another thing, if your mother took antibiotics to treat some infection (due to poor blood formula), this can also decrease the efficacy of chemo.
Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model.
https://www.ncbi.nlm.nih.gov/pubmed/26125762

And if you are still going to use Carboplatin + Gemcitabine, maybe you can add Noscapine (I couldn’t get it for my father).
Apoptotic effect of noscapine in breast cancer cell lines.
https://www.ncbi.nlm.nih.gov/pubmed/27081867
Enhanced anticancer activity of gemcitabine in combination with noscapine via antiangiogenic and apoptotic pathway against non-small cell lung cancer.
https://www.ncbi.nlm.nih.gov/pubmed/22102891

Emad
Member
Emad

Dear Ovidiu , sorry I forget something that maybe looks important but I’m not sure if it was the cause

actually we did the blood transfusion after 48 hours from Carboplatin + Gemzar infusion

we used to do blood transfusion at the end of the cycle but last time we did it after just 2 days

Emad
Member
Emad

I have to put Noscapine in my mind , things look more clear after your comments here Ovidiu

thanks a lot

Helga
Member

Hi Ovidiu,

do they add erythropoietin or that stimulating agents to patients who need/get blood transfusions? One has to be careful about it because it may increase thromboembolism: Reference

Venous Thromboembolism and Mortality Associated With Recombinant Erythropoietin and Darbepoetin Administration for the
Treatment of Cancer-Associated Anemia

Conclusions: Erythropoiesis-stimulating agent administration to patients with cancer is associated with increased risks of VTE and mortality. Our findings, in conjunction with basic science studies on erythropoietin and erythropoietin receptors in solid
cancers, raise concern about the safety of ESA administration to patients with cancer.
JAMA. 2008;299(8):914-924

Ergin
Member
Ergin

Hi Emad,
Please read phlorizin post.You can use it 4 hours before chemo.
There are derivatives of phlorizin you can find in local pharmacies i think.
I am also thinking to use it next week.SGLT inhibitor.
https://www.cancertreatmentsresearch.com/phlorizinphloretin-a-strong-glucose-transport-inhibitor/

Emad
Member
Emad

I’m considering phlorizin and Sal , they seemed to be the best things to add with chemo

but really Ergin I didn’t know that I could find derivatives of phlorizin , you think they can work just like phlorizin ?

hope yes , I love to use it soon 🙂

Wondering
Guest
Wondering

hey Emad
from above its clear that you helped your mom a LOT, maybe she would not be here without your actions.

chloroquine is cheap and would help in my view;
https://www.ncbi.nlm.nih.gov/pubmed/27060208

maybe avemar, wheat extract could help,:
https://www.ncbi.nlm.nih.gov/pubmed/15665622

pls check ogfr status in your mothers cancer, maybe ldn could help, in that regard pls search back daniels warning, :
https://www.ncbi.nlm.nih.gov/pubmed/23918871

how about 3-bp if things go really south?

Wondering
Guest
Wondering

also…my new finding (for daniel its old of course) Griseofulvin seems to effective against BC too.

http://bmccancer.biomedcentral.com/articles/10.1186/1471-2407-10-213

Emad
Member
Emad

Hi wondering , thanks for your opinions and concern 🙂

yes i think I’m gonna add chloroquine and the other off label medications that may help

regarding Griseofulvin , which one you think is the best : Griseofulvin or mebendazol ?

i tried mebendazol 600mg daily for about 1 month , and didn’t notice any help , also not sure about the quality

and about 3-BP , i really love and wish i can use it , but the big problem with it is that it could not stay in a good condition in a room temperature for few days

and there is no company that can offer fast shipping here to Libya , i don’t know how can i reach it

Wondering
Guest
Wondering

Re griseofulvin and mebandazole, im afraid there is no way to Tell, but they dont work exactly the same way. Im trying to get these both currently.

Re logistics and temp.. i have the same problem but i think i Will try if things dont get solved without it.

Emad
Member
Emad

I gave my mother mebendazol before up to 600mg daily , at that time we run out of DCA and the tumor marker climbed from 450 to 714 , it was a huge jump and I felt like mebendazol didn’t help in anyway , maybe I’m wrong

but I will see if I find a good source for griseofulvin here in our country

sad to hear that you are facing the same problems regarding 3-BP , I hope we both can get it one way or another

Helga
Member

Hi Emad,

This site claims 3-bp remains stable under ‘ordinary’ conditions. They are in India and it is already quite hot in India so… Here is the link: http://www.exportersindia.com/marine-agency-corp/ethyl-3-bromopyruvate-ukraine-1760446.htm

Emad
Member
Emad

it looks strange as other western chemical suppliers used to write that 3-BP cannot stay few days in a room temperature

I will look around again , my wish is to get 3-BP with Salinomycin , I feel that they are the only combination that can make treatment possible without chemo

veeni
Member

Hi Emad,

ketogenic diet is a good option to stop the cancer from growing. I am very convinced of its effect and believe it is a good boost for all the other treatments. There are lot of papers out there on this topic.

Kind regards,
Veronika

Emad
Member
Emad

Hi Veronika

you seem to know well about ketogenic diet , do you know about people who are doing both chemo and ketogenic diet ?

some how I feel like its hard for patients to stick with ketogenic diet while they are on chemo , I’m not sure but maybe you have some thoughts

Carl
Member
Carl

Hi Emad (sorry, I addressed you with the wrong name above),

Is your mother taking any ”re-purposed” drugs on top her current treatment? It might not be as potent as the substances you are using, but thanks to the low toxicity and significant efficiency it could probably add a lot of value? As suggested above, Metformin is probably well advised. You could consider combining it with Statins and cycle Doxycycline/Mebendazole. This is the protocol the Care Oncology Clinic prescribes.

Perhaps also consider bisphosphonates to address the bone mets http://www.cancernetwork.com/bone-metastases/bisphosphonates-prevention-and-treatment-bone-metastases/page/0/3.

Dipyridamole is also a promising agent: https://www.ncbi.nlm.nih.gov/pubmed/22760522

“Fasting mimicking diet” to potentiate the chemo and protect the immune system, and periodically afterwards to boost the immune system. Google “Valter Longo”.

What you are doing to help your mother is really quite amazing!

Kind regards,
Carl

Wondering
Guest
Wondering

hey Carl, thanks for the valter longo suggestion, some interesting read

Emad
Member
Emad

Yes I will use metformin

also my mother stopped bisphosphonates months ago due to the risk of osteonecrosis of the jaw , but she will return to it soon, the dentist made it clear that my mother can return using it without a problem

thanks a lot for you contribution Carl , you and other friends help here is amazing too 🙂

wish you the best

Ergin
Member
Ergin

Hi Emad,Please read it up to end.
It does not have a killer effect but it changes resistant cells to a sensitive level totally after 72 hours.
”Low molecular weight heparin tinzaparin antagonizes cisplatin resistance of ovarian cancer cells”
It helps on 100’s of genes related to cancer.So the other cancer types should benefit from it.
https://www.researchgate.net/publication/280693552_Low_molecular_weight_heparin_tinzaparin_antagonizes_cisplatin_resistance_of_ovarian_cancer_cells
My thoughts are very positive for tinzaparin.I wrote it 2 times on heparin post but no one is interested including me:)
But with Daniel and alltogether with friends,we can work and search for it.
I think tinzaparin deserves respect.
Kind Regards
Ergin

Emad
Member
Emad

yes it really worth trying , i hope i can find it in the pharmacies here

i have to say you are doing a great job searching a lot these days bro 🙂

sirsna
Member

Hi!

Of course, Ketogenic diet is “must try”!
I followed Patricia`s Daly advices! (check google and facebook).
I had times when I followed it quiet strictly (measuring ketone blood levels, glucose), scaling products etc., but some times only low carb. But I had in my opinion serious side effect – blood cholesterol levels went UP (my total cholesterol was 9,…mmol/L) and I have some progression in my bones in theese 2 years. Among other things, Now I am on statins.
Be sure what numbers You want to see in blood samples.
off label must be more effective in my mind!

kind regards,
ieva

Emad
Member
Emad

you remind me of some cancer survivors who beat cancer by going total natural but not with ketogenic diet

like Chris Wark , he actually against ketogenic diet and he claimed that balanced diet is much more better

hope you are doing good , I hope you beat up cancer soon , my best wishes to you

Alex
Member

Chris Wark is an opportunist.
He makes claims to potentially millions of people who are reading, watching, listening and doing.
People go blind into what he says and promotes without shame certain brands, products.
He specifically promotes the use of certain brand named devices, supliments etc etc etc.
Little to no science.
Aggressive commercially oriented cult followed unable to touch kinda thing going on there….
While i appreciate his latest series, oriented towards the natural…. i can not help but notice the commercial intentions behind his efforts. He’s doesn’t seem to be doing it to help people but rather to get people to help him. “please buy this”.
“this will cure you 100%”
“Disclaimer, nothing here will actually cure you”
More or less a joke of an idea and character he is. A survivor with good intentions once maybe, but corrupted now Says me!!!
If he got well from cancer i feel it’s just somewhat random… i doubt everyone would get the same result doing the same exact things or even better.
TY Bollinger is more mature about things in my opinion, especially in his latest videos.

Cheers

veeni
Member

I guess the most important thing is to maintain low blood glucose (3mmol). It is what Dr. Seyfried recommends.
This is also achivable with normal ketogenic diet. Actually I am in touch with few breat cancer women who are on a normal ketogenic diet and either they are cancer free or the metastasis are stable.

@ieva cholesterol is not a bad thing. See here: https://www.ncbi.nlm.nih.gov/pubmedhealth/behindtheheadlines/news/2016-06-13-study-says-theres-no-link-between-cholesterol-and-heart-disease/

kind regards,
veronika

veeni
Member

Sorry, I ment blood sugar 3 mmo/L is the recommendation from Seyfried.

sirsna
Guest
sirsna

HI, Veronika!

Yes, Seyfried`s recommendation is blood glucose 3 mmol and ketone levels in blood 3 or more (starvation ketosis). That would be ideal proportion. All is about glucose ketone index:

https://optimisingnutrition.com/2015/07/20/the-glucose-ketone-relationship/
http://nutritionandmetabolism.biomedcentral.com/articles/10.1186/s12986-015-0009-2

I don`t understand what You mean by “normal ketogenic diet”?

I am not interested in herat desease and high cholesterol, my point is to minimize everything, who can drive cancer.
And that is not only glucose, especially, in advanced cancers.

kind regards,
ieva

Meech
Member

When I spoke with Dr. Seyfried, he didn’t outline what blood glucose values you should be getting. This was his quote:

“You can gage the efficacy of metabolic therapy by measuring your daily Glucose Ketone Index (GKI) while under a medically supervised ketogenic diet. You simply divide your blood glucose value in mmol by your blood ketone value in mmol. However, most blood glucose meters provide glucose values in mg/dl. You simply divide this number by 18 to get the glucose value in mmol. It is our view that therapeutic efficacy will be potentially best with GKI values as close to 1.0 as possible. It is also best to measure the GKI 2-3 hours after eating.”

So even if you’re above 3mmol/L, as long as your ketone levels stay in the range of your BG values, it seems like it’s okay?

sirsna
Member

You are right, As I mentioned above, in the Keto diet one of the focuses is on glucose Ketone Index.

Emad
Member
Emad

I wonder how much it may take to see effect from ketogenic diet ?

and is it easy to stay in the proper ketone levels or its sometime going out of control ?

sirsna
Member

It takes few days for body to start to make ketones, it like transitional period, maybe with keto flue like symptoms. Dr.Seyfried sugest just 3 day fasting and then You are switched :). I did not fast for 3 days. I followed carb restrictin to 20g/day, protein ~60-100g/day, fat ~100-120g/day. My ketones were ~1-2mmol, but I mentioned good ketones number growth when I combined it to intermittent fasting – my ketone numbers went to 3.5 or even higher and i felt very good and clear minded. I liked it.
At the first time body will tend to go back to glucose burning, but with time, it will switch to prefer ketones. But it can take a lot of time. MCT oil can help (I have not used it). I take pure coconut oil (there is some connection with medium chain triglycerides in this oil and how our body to use it). MCT oil is pure medium chain triglycerides and thus maybe better not to get high cholesterol levels.
Everything that stress You can put You off keto state – even coffee, running, (I am not sure about hypothermia :), but think that also will stop keto state).

In my mind for us is better to focus on intermittent fasting with just low carb diet (just make fasting windows for 12-18 ours or what Your body prefers). It should minimizes Your glucose levels, minimizes insulin spikes (and IGF-1) and as Carl mentioned – there are other huge benefits with intermittent fasting. And do not eat anything with hidden sugars.

have a good day,
ieva

Helga
Member

Dear Emad,

I am not sure if Daniel already mentioned this but DMSO is something that is also worth to look into: https://www.cancertutor.com/dmso/ Allegedly it is a fantastic solvent, it will penetrate the skin and whatever you add to it, will be delivered to the tumors with the help of DMSO. I have never tried it but I come across it every now and then on alternative cancer treatment websites. It will work with both acidic and basic components. In fact the concept “pH” does not apply to it. It will work well with colloidal silver.

Some places cesium chloride is also recommended with it but I heard it is a dangerously alkalic molecule and it can cause harm. However, DMSO itself is pretty harmless and a very useful chemical.

‘…it was shown that DMSO targeted cancer cells. Is it any wonder that the referee of the article stated:

“In spite of my criticisms, there are some parts of this study which do interest me very much. The fact that the Haematoxylon [a color die, which allowed the researchers to see which cells absorbed the DMSO and haematoxylon] and D.M.S.O. solution had a particular affinity for neoplasms [i.e. cancerous cells], and did not stain other tissues in animals could be most significant.”

Read More http://www.cancertutor.com/dmso/
…’

There is another website with several cases of bone cancer or metastasis treated with apricot seeds. I am not sure how much truth is in the stories but there are email addresses provided for the patients so you can contact them directly and ask them. Here: http://www.apricotsfromgod.info/testimony.htm

Apricot seeds/B17/Laetrile was considered by a serious cancer center before they started to ridicule it so there must be some healing power in it, I am pretty sure. The fact that any distributors/promoters are so heavily ostracized in the US indicates it too.

Kind regards,
Helga

Helga
Member

Yes, that “serious cancer center” again turns out to be Sloan Kettering Memorial Cancer Center, told by Mercola: http://articles.mercola.com/sites/articles/archive/2014/10/18/laetrile-cancer-research-cover-up.aspx

SK buried its related research but there are some more recent articles authored in Germany and other countries.

Here are just a few of the more recent studies that substantiate Dr. Sugiura’s work:

August 2014: In a new German study, amygdalin dose-dependently reduced growth and proliferation of bladder cancer12
May 2013: Amygdalin inhibits renal fibrosis in chronic kidney disease; researchers conclude it is a “potent antifibrotic agent that may have therapeutic potential for patients with fibrotic kidney diseases”13
February 2013: Amygdalin induces apoptosis in human cervical cancer cells; authors conclude it may offer a new therapeutic option for cervical cancer patients14
August 2006: Amygdalin also induces apoptosis in human prostate cancer cells15
February 2003: Amygdalin from Prunus persica seeds (peach pits) shows anti-tumor effects comparable to epigallocatechin gallate in green tea16

Helga
Member

ps. There is quite an interesting story at the same site: http://www.apricotsfromgod.info/mystory.html
The guy controlled his kidney cancer for 25 years with apricot seeds. He has been in jail in the meantime for selling or propagating the seeds during which time his cancer came back. An incredible story!

Alex
Member

Dear Helga,
With all respect i write to you.
Don’t trust everything written on cancertutor
Also, apricots as seeds would have to be ingested something like 2kg / day for any terapeutic effect. *let’s be real here*
The extract, iv etc. is extremely expensive, at least here where i live, and as i understand it…. even that is weak for cancer and not something someone would be able to sustain as treatment for very long due to financial reasons.
It sounds to me that Diclofenac would be a more powefull against cancer https://www.youtube.com/watch?v=OjkzfeJz66o

Best wishes,
Alex

Wondering
Guest
Wondering

I agree.

Probably there is some truth in b17 properties but I have the feeling its being “oversold”, there are peole who keep advertising it, there are shiny webpages around it, price is high ( you can buy lots of stuff with more proof behind that cost 1% of laetrile’s price).

I even hate the fact that advertising people call it a vitamin – while its not.

eating apricot seeds was a great fun though when we were children. Some adults kept telling us not to eat more 10 per day, we never counted.

Alex
Member

i love apricot seeds, as a kid and now.
I ate a lot of them, they didn’t even give me indigestion so for me in my personal opinion they are not poisonous at all.
Tooth paste is more toxic than apricot seeds, so it seems to me.
As far as them being anti-cancer, i seriously doubt it.
It’s being promoted all around the internet that eating a few apricot seeds a day will make your terminal cancer go away rofl.
Oh and don’t eat too many because your cancer could go away too fast lol.
That hidden truth that nobody wants to expose, the forbidden cure FDA keeps away from those in suffering.
Obviously a big stream of advertisement, a movement aimed at the desperate.
The pure substance iv however “may” have “some” effect if any, Good or bad or neutral.
i rather not spend thousands upon thousands of $ on something that may do absolutely nothing.

Helga
Member

Dear Alex,

Naturally, I approach everything with a critical mind, that is why I cited a reviewer’s comment on a scientific manuscript submitted to a scientific journal. However, could you expand on your view as to why you think cancertutor is not to be trusted in particular? Do you have any bad experience with it or with DMSO?

Re: apricot seeds, it in itself should not be expensive or difficult to find. Perhaps laetrile is oversold/hyped indeed. What makes you think that we would need to consume 2kg to make a difference? It would be nice in general if people didn’t make statements like this without at least some supporting evidence. That is what makes Daniel’s site unique, there is always an effort to support therapeutic suggestions with explanation/scientific or anecdotal evidence/or at least a plausible hypothesis.

I know I myself find things sometimes that might not stand scrutiny in the long run but I always try to find and cite the source of the statements at least.

Cheers,
Helga
ps. in case there was any evidence given in the youtube video, I have no time to watch them as I can read much faster than listen to people on youtube.

Alex
Member

Also check out this about B17 https://www.youtube.com/watch?v=w8KPhT2xGL4

Helga
Member

There is another interesting substance, called ursolic acid: http://www.tbyil.com/Oleander_Cancer_Discussion.htm

There are several recent scientific articles proving its anticancer effect, e.g.: http://www.nature.com/articles/srep14570
“Ursolic acid exerts anti-cancer activity by suppressing vaccinia-related kinase 1-mediated damage repair in lung cancer cells

Many mitotic kinases have been targeted for the development of anti-cancer drugs, and inhibitors of these kinases have been expected to perform well for cancer therapy. Efforts focused on selecting good targets and finding specific drugs to target are especially needed, largely due to the increased frequency of anti-cancer drugs used in the treatment of lung cancer. Vaccinia-related kinase 1 (VRK1) is a master regulator in lung adenocarcinoma and is considered a key molecule in the adaptive pathway, which mainly controls cell survival. We found that ursolic acid (UA) inhibits the catalytic activity of VRK1 via direct binding to the catalytic domain of VRK1. UA weakens surveillance mechanisms by blocking 53BP1 foci formation induced by VRK1 in lung cancer cells, and possesses synergistic anti-cancer effects with DNA damaging drugs. Taken together, UA can be a good anti-cancer agent for targeted therapy or combination therapy with DNA damaging drugs for lung cancer patients.”

The good news is that ursolic acid is easy to find in plants, e.g. in the skin of apple, rosemary, basil, etc: https://en.wikipedia.org/wiki/Ursolic_acid

You can also buy it as a supplement: https://www.amazon.com/Labrada-Nutrition-Ursolic-Capsules-200Mg/dp/B008E470LQ

Emad
Member
Emad

Thanks a lot for your comments and help Helga

I will take a good look on Ursolic acid , I wasn’t aware of it until now

but regarding apricot seeds , I wonder if its better to take about 30 seed daily or to get laetrile as IV ?

Alex
Member
Alex
Member
Alex
Member
Helga
Member

Hi Emad,

I am rooting for your success at treating your mom. I didn’t know that you are in Libya and a medical student. Very interesting. We in Europe hear only sporadically about your country and usually only bad things. How is life there these days, I wonder?

Re: ursolic acid, allegedly this is even better: https://en.wikipedia.org/wiki/Betulinic_acid
For its source I recognize only rosemary in the list and there is this flower: https://en.wikipedia.org/wiki/Pulsatilla

Allegedly it is toxic when ingested in high amount. This brings me to my theory: quite often cancer is treated successfully with weak poisons. Like apricot seeds for example. While it is toxic for normal people, it might be less toxic for cancer patients whose cancer produces the enzyme that breaks it down in high amount. On the other hand, the opposite can be also true, namely healthy people’s detoxification system works better than that of cancer patients.

Ah, sage too: https://www.ncbi.nlm.nih.gov/pubmed/21894557 It has tujone in it, which might be also toxic in high amounts, however it has a good anticancer profile as well.

Cheers,
Helga

Helga
Member

Ah, didn’t realize that thujone is named after thuja: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3106972/
“Thujone-Rich Fraction of Thuja occidentalis Demonstrates Major Anti-Cancer Potentials: Evidences from In Vitro Studies on A375 Cells”

Helga
Member

Thujone is toxic in high amounts: https://en.wikipedia.org/wiki/Thujone

It is the infamous ingredient in absinthe, a liqueur, which was banned for a while due to its (perceived?) toxicity. Absinthe was very popular in the early 20th century.

Aha, thujone is also found in Artemisia!

Emad
Member
Emad

Hi Helga

thank you for your concern

unfortunately things are getting worse each day here in Libya , controlled by a bunch of criminals who have the power and the ability to make things better , but they only do every thing to make things worse

God give me strength

————————-

regarding Allegedly and ursolic acid , they are interesting and new to me , lot of things to about them , I will put them in my mind

thank you so much

Emad ^__^

Wondering
Guest
Wondering

hey emad, offtopic, yes, sad for you guys, hope it will be better in your lifetime. our government in hungary is also a bunch of criminals (worst in eu)but of course different level. be strong.

Alex
Member
Emad
Member
Emad

thank you dear Alex

I saw the videos , interesting

regarding laetrile I’m not sure if the oral version is worth trying like the IV version

but the problem like you said that IV version is expensive

regarding Oleander , this one Ergin used in the beginning , is it used as IV or oral ?

and which are better ? and how about there prices ?

I was aware about Oleander , but not that much

but really I should take a very close look on it , it seems helpful to so many peoples

Alex
Member

Ergin may help more than me on that…..
Personally i think it makes sense to first get your mother feeling better with adequate nutrition, detox, hydration. Too much treatment……
Get her feeling better, relax a little…
“Zoom out” as Daniel likes to say. More testing for other things, not just tumor markers. There are many treatments…
But they won’t work if you go blind into them, you have to know more about your mother’s bio-chemistry, hormone activity, immune system etc etc etc.
I personally believe that “modern medicine” is unaware of the full view. So a broader view is needed. Zoom out.
See what caused the problem, fix what is wrong, help the body recover, do what can be done non-toxic, hope for the best.
All these remedies will do nothing if the organs, glands, etc are not working in harmony, the mind, emotional situation is HIGHLY IMPORTANT!!!
Sometimes a small gesture can help a lot.
Chemo will work, but it wont do it completely, and the body can only take so much of it, same with the others.
“The body is not deficient in chemotherapy you know”.
So clearly we are missing something here aren’t we? I realized that after my mother’s surgery, i wish i did so earlyer.
All this may sound like mambo coco jambo, i know… Mens Sana in Corpore Sano
I’m curios to know what you think.
I wish we were all together in the same room, we would then help each other so much.
Many thanks,
Alex

Emad
Member
Emad

yes sometimes we need to be relaxed and regroup our thoughts so we can act better and take better decisions

you said it all man thanks a lot

I remembered something btw , I was about to use DCA with HCA + CA , but lost the road again after I read about possible interference between CA and DCA

maybe I will take the risk and combine them all , but looks crazy decision , not well studied and against your opinion huh 😀

Alex
Member

I dont know everything. so maybe what you feel or think is better.
Instincts were telling me, based on the science explained to me by Daniel, that DCA+CA, are not a good idea.
But out of respect and being aware of how little i know about all of this, that i could be wrong, i decided to shut up, a small mistake….
Sometimes it’s best to look stupid, ask stupid questions, you never know….
1000 stupid questions 1 Genius question – Nobel Prize, etc etc etc. lol

Alex
Member

Instead of B17, Layetrile, Amigdalin, Apricot Seeds, i would go with a good old diclofenac, aspirin, paracetamol etc.
They are 10XXXX times better, that’s how i feel. Waste of time, money, hope, energy etc.
Maybe the IV version would do something….. something…. idk, not interested in throwing money at it. Did enough of that on other useless things already. Such as Graviola, Paw Paw
They are all marketed as wonder miracle cures. “Don’t take too much, you may get rid of your cancer too fast, watch out!”
Sometimes i hate this planet, no wonder the aliens aren’t coming to visit, we are not worth it. Primitives still valuing $ more than life. Pathetic.
Anyway, Daniel want’s us to make our own choices, probably because he feels he doesn’t have all the answers. Maybe…
I know deep down inside he thought about all this very very very good. But he’s trying to hint towards the best possible answers to our problems. So to Daniel’s time consuming pleasure, we should do our best to keep asking questions, one or more of them may be the right ones, that may lead to our personal right path.
To stop asking questions is to stop looking for answers
While the answer may not come, the question was addressed and a connection may be made later on.

Cheers
ALex

Emad
Member
Emad

I totally agree with you

and regarding diclofenac , I’m just worried about the long term side effects , what do you think ?

its a good choice when also using DCA , I may consider it but not sure how long we can stay on it

I really hope we can meet each other one day , I really hope that

this blog is like our home 🙂

Alex
Member

What i can say is that my mother was taking diclofenac before diagnosis, relative high doses, 200mg/day i think, for about 6+ months
She had existing heart problems, so if that’s not an issue maybe one could go higher.
It’s also the thing that i believe has made the tumor stay in only one place while growing. the doctors were surprised that she didn’t have massive mets, They did see something but were uncertain…..
Cancer cure? i think not….. Something that will help?! for sure!!! Risks? Always….
May wanna check out simvastatin while you zoom out a bit from all the chemo rush.

Emad
Member
Emad

Thank you so much dear Alex

I started to give my mother metformin , around 1.5 to 2 g / day

maybe next time will add diclofenac and chloroquine

the only long term side effects I’m worried about when using diclofenac is being hard on the stomach

but I feel it can help when always I’m reading about it

hope to always hear good news from you 🙂

Alex
Member

Start slow with metformin, you don’t want her feeling bad, migrenes. IF you get that, give her something sweet
If you are worried about stomach problems, i believe disolving it prior to swallowing with food, may help.
We alternate Diclofenac day, Aspirin day. Diclofenac Day, Aspirin Day but always with metformin
Omeprazole also helps protect the digestive system
I am sure we all have a lot to learn from each other.

Mother is feeling good, we developed a rating system for pain, 0-10, she is at 1.5 she is not taking heavy pain killers on opium or morfeene etc. We check pain to see if things are getting bad or good, real time markers?!
I know aspirin and diclofenac are pain killers but they would do little for pain compared to heavy drugs.
So i hope/believe the lack of pain would indicate slowing down, stagnation, remission of the cancer.

There’s plenty of stuff out here, try to build your defense then see if chemo is needed. eh?
You have to make a fortress, all known vulnerabilities checked.
Cheers
Alex

Wondering
Guest
Wondering

Hi emad, you can buy diclo combined with a stomach protector, i dont remember the name but u Will find it. Less risk then..

Emad
Member
Emad

Thanks a lot Wondering

I hope this will help while on diclo

Helga
Member

Hi Emad,

I am not sure if your mom takes omega 3 but acc. to Daniel’s article there was a signif improvement of late-stage breast cancer patients by taking it: https://www.cancertreatmentsresearch.com/1443/ He suggests that all patients take it. Oh, I remember you said she takes Budwig but maybe not in a high dose. Daniel says some people take 15 grams per day.

Emad
Member
Emad

we used to take Budwig with good doses suggested by cancer turor , but my mother didn’t tolerate its taste easily and sometimes started to vomit it

but I hope omega 3 capsules can be as good as flaxseed oil

I keep wondering why there is no such thing like budwig diet but in capsules !?

it should be helpful for the entire body in everyway

Pouya
Member

apparently EFA’s Companion Nutrients is supposed to make one flaxseed oil water soluble. I didn’t try it so I can not vouch for the efficiency but it was one the things I always wanted to get since Budwig diet is indeed hard to maintain for a long time.
https://www.bionatures.com/products/efas-companion-nutrients-complex-500-mg-180-capsules-2-month-supply

Pouya
Member

I meant one teaspoon of flax oil.

Emad
Member
Emad

Thanks a lot brother Pouya , this one could really help

its really a very good thing to be able to have something like budwig in capsules

hope you are doing good , we will talk soon 🙂

Helga
Member

Hi Emad,

We make Budwig with added ingredients. We use a mixer and add green leaves, like spinach, arugula, etc. I also add, for taste, and health, parsley, sage, rosemary and thyme (really, but here is the Simon & Garfunkel song, called Scarborough Fair: https://www.youtube.com/watch?v=cfA8rz5PKrA with these 4 plants :-))

Or you could also add fruits if your mom can take/tolerate that.

Best,
Helga

Pouya
Member

btw if your mom has a dental amalgam be careful with ALA as it is a mercury chelator. (as far as i know)

Alex
Member

Metal fillings are toxic and should be removed right away. 🙂
So i hear…

Emad
Member
Emad

yes they should be removed , but carefully

i read in cancer totur that if the mercury amalgams not removed correctly , then probably it will make things worse and a lot of mercury will fall or be swallowed

also what he said that it may cost around 10,000 dollars to remove them in the right way as he explained

here in our country you may get infection easily for just a normal dental work like cleaning your teath !!

Emad
Member
Emad

I should put that in my mind as my mother has many mercury amalgams in her teeth !

Alex
Member

cancertutor is exagerating a lot….. a lot…..
A dentist (especially if made aware) with a little incentive, will do the job right for you and your mother, no need for 10.000$.
The less mercury the better. 🙂
The less toxins the better 🙂
To be honest after all the chemo, i kinda feel mercury amalgams are the smaller problem to address at this time.
If you and your mother wish to stop chemo, you have to detox, and detox and detox and detox and detox….. ………. ………. …….
First there is the intoxication in the body to address, then there is the intoxication sources in the house etc.
Don’t believe everything out there. 🙂

Cheers.
Alex

Emad
Member
Emad

I agree , and with that our first goal in our treatment plan is to find a better way to stop cancer other than high doses of chemo

its not easy at all , hope we can somehow do it

jondoeuk
Member

”In a clinical pilot study with nine breast cancer patients, diazoxide was used at a dose of 200–300 mg per day [4]. For inclusion, maximal tolerated fasting glucose level was 110 mg/dL, and 180 mg/dL after an oral glucose load with 75 g. The best response was seen in a 60‐year‐old woman, who had glucose levels of only 56–105–115 mg/dL in the oral glucose load test. After progression of her cutaneous metastases during tamoxifen treatment, she was supplemented with 200 mg diazoxide per day and her fasting glucose levels rose to 90 mg/dL. Partial remission with this combination ended after 7 months when liver metastases were detected sonographically. Two months later, both medicaments were withdrawn because of rapidly growing cutaneous metastases and pleural effusion. Another 2 months later, the patient exhibited a rebound response of 4 months duration with the disappearance of pleural effusions, partial remission of the cutaneous metastases, and stable size of the liver metastases. In two additional patients with prior disease progress, diazoxide treatment resulted in stable disease of 8 (combined with tamoxifen) and 4 (monotherapy) months [4].” http://theoncologist.alphamedpress.org/content/22/4/491.long

Emad
Member
Emad

Tumor marker results today

it shows a slight increase on ca15-3 , from 608 to 611

but also I believe that the markers actually decreased , because we delayed the chemo 5 days , and the markers were progressing incredibly fast , so I think they become more higher than 608 before chemo

I can see we stopped the progression , so this is good news for me

but that bad news is : DCA will rest in peace , after using it for about 1.5 year , it lost its effect

also the neuropathy become worse , so once I receive 3-BP and Sal , I will stop it , maybe will give it a shot before the chemo day only

we used to have a better results in the past , now we almost have a stable disease only

I hope to find a good results soon with my next strategy

and by the way , nice to be here again , as I nearly got a heart attack because of the panic before I get the results

thanks my dear Pouya you have been supporting me today , I really appreciate your existence, thank you so much

also thank you Ergin for your emails and concern and continues help , I wish to get my hands on a strong protocol next weeks , so we can have a solution for both your mother and my mother , really wish the best for you

Daniel , thank you my man

the war become much harder but as much it become hard , I believe that time we could find the solution

I will do my best not just to help my mother , but also to lead people to a much stronger protocols that can bring hope back to them, and of course with the help from God then finally with your help

Emad
Member
Emad

Dear all

2 weeks later , CA15-3 was 611

since that time , we did blood transfusion in the same day of the result , then only DCA for 2 weeks

today, in another lab test , CA15-3 show high elevation to 1443

also liver enzyme test is so much concerning me

AST = 95
ALT = 59
GGT = 163
ALP = 129
Bilirubin is normal
all the other tests are normal

tomorrow the CT Scan and PET Scan results will come , i will share the results soon

Jcancom
Member

Dear Emad, I am reading these comments and I feel so badly for you.
You have done such a great job and this is not fair.

Emad
Member
Emad

Thank you always J for your care and kind feeling

we will do our best to re control things again

today the oncologist did see our results , she was worried about the progression that happened

she did contact some other specialist and then decided to change the chemo to another new combination

we used to take Carboplatin + Gemzar , and the both are heavy on the bone marrow which always lowering the blood counts and then delay the chemo and require blood transfusion

the new combination she suggested is (Cyclophosphamide 1g + 5-FU 1g + Methotrexate) every 3 weeks

also like always , the bone lesions are still stable more than a year ago

I don’t know why whenever we talk to a conventional doctor they told us that TACE is not required !!!

is this because TACE is not an approved method for breast cancer or what ? I really don’t know how they think

but anyway we decided to do TACE as quickly as possible , the liver masses must stay small like before , my biggest ever nightmare is liver cirrhosis or ascites , and I can’t rest peacefully until there is no more risk of such things

I will continue to share things all the time

wish the best for me and all of you brothers

Emad
Member
Emad

I send a comment which I can’t see it

I’m sure Daniel will pick it up from the spam filter

Alex
Member

Dear Emad.
I am filled with pain over many personal reasons and it kills me to hear things aren’t going well for you and your mother despite all the huge sustained efforts.
I wish i could do more than just write a message.
Perhaps there’s something to be done still.
Local Hyperthermia, DCA+ the rest
I always wonder why you didn’t go for oral administration of DCA, daily, why no vitamin B1, why …? The small things like diclofenac, aspirin, metformin, they all have their major contribution.
From reading your story i gather DCA has been more effective than chemo all together. This may be wrong.
Maybe this LDN, and T4 depletion, coupled with diet. GcMAF, nutritional elements meant to sustain health.
I am sorry i am saying maybe, it’s all i got. I’m still very much interested in 3bp and Sal myself, for my mom.
Thank you very much,
Let me know,
Alex

Emad
Member
Emad

Hi Alex

the capabilities here in Libya are so weak , no hyperthermia available , they even don’t know about such thing , I’m still doing DCA IVs , but its not helping like before

what I know is that IV DCA is better than oral , I’m still giving my mother B vitamins , I know the potential of NSAIDs but I’m not sure if its okay to use them continuously , also my mother is taking metformin now for over a month , 2g daily

LDN is not available I wanted to use it but I’m waiting for 3-BP + Sal to arrive , T4 depletion is a good strategy that I was thinking to use it for a while , but first I want to use the up coming strategy , also it needs time to work

GcMAF is not a good option when chemo is still used , the immune system is weak , I have to wait until that day come when my mother could finally stay good without chemo

but as I said before , the liver masses cannot wait , we have no fast option other than TACE , and the first session should be done this month , we have the ability to cover the first session , but for the others we may have some help from our government

also from our poor government we have a chance to be treated in Poland , I don’t know if anyone have any information about good clinics there !?

and btw , thank you so much for your concern and feeling dear Alex

I wish your mother is feeling good , how is her now ?

Wondering
Guest
Wondering

hi Emad

good luck with anything you decide to go for… hyperthermia i am considering currently.

how come this polish opportunity? is there an agreement between the governments?

Emad
Member
Emad

No agreements at all

but one of the governments which has some power actually are still having the ability to give some cancer patients an opportunity to have a treatment in Poland , I don’t know why Poland exactly

but still it needs some time to complete the regulations required for having this help, I hope the clinic they are sending us to it have more than just the nasty chemo

Meech
Member

Hi Emad,

I couldn’t reply to your other comment there so I’ll reply here.

When he says “three to four monthly sessions”, he likely means 3-4 in one month. I’m not 100% on how effective one session every three months would be; I think you should email him. He answers emails within a few minutes usually.

About the procedure: it’s mostly painless but a bit uncomfortable. You may feel a bit of pain first with the local anesthetic needle, then with the initial puncture into the artery, which doesn’t last a long time (a few seconds), and then some discomfort internally as he passes the catheter through, but it’s nothing serious. Each procedure took about 10-15 minutes, but there are MRIs beforehand, then resting in bed for three hours afterwards, then a quick CT scan without contrast immediately after the three hours. Then you have a consult with Prof. Vogl to talk about the procedure, which lasts about two minutes as he doesn’t speak too much. All in all, you’re probably in the hospital for 5-6 hours, and are then free to go.

My condition is good, from a subjective point of view. I don’t feel pain, I’m not tired from the cancer, I work out, go out, etc. It’s hard to tell that I even have it, apart from having to have a nephrostomy tube, and some palpable tumours. However, CT scans tell a different story. I have it in all six lobes of my lungs, multiple lesions in my liver, at least one bone tumour, and I can’t even count how many lymph nodes. Every CT scan I do, I have new spots of metastasis. However, for whatever reason, once the tumours do seed somewhere, they don’t seem to grow very fast.

Thanks Emad; I hope the same for your mother 🙂

Wondering
Guest
Wondering

damn cancer, Meech. I cheer for you.

I have no visible met and currently normal markers but i feel worse than you (constant back pain, neuro problems). I will have a brain MRI soon after 4 negative spinal MRIs.

i fear i have leptomeningeal carcinomatosis – the only thing worse than a brain tumor.

what about using 3-bp in your case?

Meech
Member

See if the treatments you did can leave permanent damage to those systems. Use of platinum based chemotherapy can lead to neuropathy. Radiation to those areas can also lead to more long-term problems when scar tissue builds up in the area. Hopefully, as debilitating as it may be, your issues are iatrogenic and not pathological.

I haven’t actually really considered 3BP and it’s mainly due to the knowledge needed in terms of preparation and administration, as well as not hearing enough positive case reports to warrant such a huge commitment.

There is a local clinic here offering the treatment (or at least there was), but when I called to ask about it, they seemed much more concerned with their more “promising” therapy (which I believe was insulin potentiated chemo), than with what they seemed to consider a more minor therapy in 3BP. Which led me to believe that either they were concerned with a profit motive, or they genuinely weren’t seeing any sort of miraculous response with 3BP.

Wondering
Guest
Wondering

I had lots of cisplatin (worked big time for my only visible tumor and did not have typical side effects other than hair loss) so oncologist blamed everything on it at first.

After round 1 (september) i developed back pain and from November I started having mild but clear CNS symptoms (not peripherial neuropathy which is normal with Cisplatin). Some of these remained as they started out – some of these are stronger now.

Lets hope im one in a million who reacts to cisplatin like this but im realistic (and hence pessimistic) – i think its cancer.

Emad
Member
Emad

Thank you Meech , your comment is so helpful , I will always wish the best

I have a little question , did prof Vogl asked you to give him a CD (latest CT scan results) before starting on TACE ?

if yes , then did you uploaded the data in the CD then give him the download link ?

or you did transfer (ship) the physical CD to his location ?

I know its confusing but I don’t understand why he can’t just download the data I gave him

Meech
Member

He did ask for the images and some reports. I shipped the CD to his physical location, these CT scan files tend to be too large to send via email.

Emad
Member
Emad

Oh my !

I thought we can visit him after 10 days , but sending the CD it self can take a week or more

like we are living in 199x , they cant just download the files or am I wrong ?

Emad
Member
Emad

Thanks Daniel for making things clear , we found a friend in Germany who can help by downloading the soft copy and burning it on a CD to send it to prof Vogl quickly

I asked prof Vogl to provide the address to send the CD right to it, but he is not responding today , maybe because its the weekend

anyone still remember the address ?

Emad
Member
Emad

I didn’t thought this address could do the job , thank you so much Daniel

Ergin
Member
Ergin

I highly believe in dapagliflozin.Please look at the photo below.There is no glucose inside tumor.It is sold in pharmacies.
I am planing to work on dapagliflozin and create a forum topic metformin vs dapagliflozin vs 3BPvs 2DG with your help friends.What do you think?
http://www.pnas.org/content/112/30/E4111/F11.large.jpg

Emad
Member
Emad

compared to phlorizin what do you think Ergin ?

could it be like it or its less potent ?

Ergin
Member
Ergin

Hi Emad,

Phlorizin is very special.There is a term called phlorizination in science world.
You use it once before chemo,perfect,i like it.But not oral and you know how hard to use,a very long iv infusions,control control.
(But 12-24 hrs is enough)Probably using it with 3BP makes the treatment very strong.In phlorizin patent they use similar.
Others are oral drugs and after chronic use of drugs,i think you reach your goal after days or weeks like all other treatments.At the end there is no glucose inside the tumor which expresses SGLT.It depends on us how we use it.What dosage?Which type?
I think we have to talk on it and combinations with others.
Emad,When i saw only 113 people is registered but nearly 1 million enterance ,first i highly demoralised.Than i began to look from another side of view.People here are really different than the other thousands.We are learning everyday by Daniles and registered friends helps.It is not clear that we are always doing right treatments,but at least we are trying something for us and people.We are not secreting knowledge.If we were 1000 people here,it would be the biggest clinical trial.
Now we are talking on 10 people.It is impossible to talk about treatments worked or not worked.
I have an idea to write mails about SGLT inhibitors to experts and write here.What do you think?

Kind Regards
Ergin

Ergin
Member
Ergin

Dear Daniel,
I am very sorry that i wrote your name wrongly.

I am working on it.And have to talk wtih endocrinologist on tuesday.
When and why do they give it to diabetic patients,any side-effects?
Can we use metformin+dapagliflozin together?Max Dosage?
Is there any iv form?Can we use it with diuretics or beta-blockers?With T3?I hope i get the answers but not sure.
Its effect on cancer is clear for me.But the others is more important for now.
Because i am only afraiding of hypersensivity to chemo.After 2 big reactions.And still couldnt find the answer.
I will write the post on thursday or friday after coming from chemo course if it is suitable for you also.
Kind Regards
Ergin

Emad
Member
Emad

I will consider it next after Sal + 3-BP or maybe I will add it to increase effectiveness

but Dapagliflozin it self I think its not available here in Libya

its worth a try

sirsna
Member

“We find that Canagliflozin, but not Dapagliflozin, inhibits the proliferation and clonogenic survival of prostate and lung cancer cells. ”
http://www.sciencedirect.com/science/article/pii/S2212877816301314

Ergin
Member
Ergin

Hi Sirsna,
Daniel found that article before,this article really downs my motivation.In some of its sentences it says,glucose deprivation is not enough.
Yes we know that and we want to use glucose inhibition for enhancement of treatments and slowing cancer and in some cases it kils cancer.What i learned from months is not to trust to all papers.There are some derivatives of SGLT inhibitors and i like them all.I found Only Dapagliflozin in pharmacies here,
But Canagliflozin looks better.
Daniel has already created a perfect post about phlorizin(SGLT1+SGLT2)but no one is interested.
So i found a way to attract peoples attention about SGLT inhibitors.A photo that shows there is no glucose inside the tumor after dapagliflozin.Because reading is too hard for people.They already have lots of problems,they need a clear explanation to begin treatments.And there are a few articles about them.Thats why we always need Daniel’s help.
His posts are really a summary of cancer treatment world.
But you are the first people interested and searched for SGLT inhibitors.May i ask your illness if it is not private?
Kind Regards
Ergin

Wondering
Guest
Wondering

Hi Ergin,
i believe the disinterest arises from the circumstance that most people can’t IV themselves and dont have open minded doctors. in my country doctors strictly rely on protocols – i am surprised to see that turkey is more liberal in this aspect.

Helga
Member

Hi Ergin,

look at this page, it seems that some online pharmacies also sell canagiflozin in Turkey: https://www.pharmacychecker.com/brand/price-comparison/invokana/300+mg/

Even though I am not sure what that means. But, it being a tablet, it should be possible to buy it online anyway. Although not cheap, one pill is about 4-8 US $.

Here is a nice article about canagiflozin: http://www.sciencedirect.com/science/article/pii/S2212877816301314

Helga
Member

Here is a nice article about canagiflozin: http://www.sciencedirect.com/science/article/pii/S2212877816301314
“The diabetes medication Canagliflozin reduces cancer cell proliferation by inhibiting mitochondrial complex-I supported respiration” Oops, I may be citing the same article that Sirsna already did, sorry. But it is interesting because it also further elaborates on the mitochondria – glycolysis conundrum, namely, that mitochondria are quite functional in cancer cells.

Emad
Member
Emad

New update

today , my mother did her first TACE with prof Vogl in Germany

both my parents are there , I’m still here in Libya

the procedure didn’t take more than 10 minutes , there was a lot of patients there from all over the world

my mother is feeling good , prof Vogl said that we made it to TACE in the best time , and glad we didn’t come late

I wonder if the tumor did change since the last systemic chemo , i hope the systemic chemo did some positive effect

also prof Vogl said that we can continue systemic chemo in time (May 31) , in his opinion its not very aggressive

and he said that we should do the next TACE after 4 to 6 weeks , or 8 weeks maximum

also 3 days ago we received Sal + 3-BP , I’m planning to use them after my mother return back probably on Friday

that’s all we have until now , i will continue to share everything in time , wish the best for all of you 🙂

Alex
Member

Our good wishes go with your mother, family and you dear Emad.
Estimated costs for TACE?

Emad
Member
Emad

thank you dear Alex , my best wishes also for you and your dear mother and family to always stay healthy and happy

the total cost for 1 intervention including scans , tests , chemo drugs , all is about 3900 euro

how things are going with you ?

Alex
Member

Thank you very much.
wow at that cost. 🙁
My mother is having pain…. however it goes away with diclofenac, no problem.
The pain appears to be caused by treatment. Diclofenac did nothing in the past with regards to pain so this is new.
Neuropathy just occurred today. This would confirm that oral treatment works with regards to absorption.
Took almost a month for this to occur. Markers grew but it would seem they did so at about 50% slower.
We’re getting a scan done soon and the much awaited story will also be available here soon after i guess.
Best wishes there, good luck.
Thank you!
Alex

Emad
Member
Emad

yes the cost is high , our only chance to continue TACE is to have a help from our government which is somehow possible but also hard

as I said before , my mother did also felt pain after DCA for days , she felt pain in her bones , also she was taking DCA with chemo at that time , and the bone mets did shrink and become very small , and since that time the bone mets didn’t change and become stable for more than a year , and it still stable until now

I hope to hear a very good news after the scan results , I’m sure that time will come when you feel happy

kind regards
Emad

Emad
Member
Emad

These 2 images are from the latest scans done in Germany , I don’t know if its from MRI or CT Scan , the liver tumors are visible and clear , I can’t know if its bigger from the last scan done 2 weeks ago or its smaller

comment image?oh=cc55f952dc907db0ebd448a39af94465&oe=59BC830D

comment image?oh=685394cdece867e8bc8c39c2cd704f55&oe=59AEBB0B

but I have a good feeling that we can make things better soon

the incoming days I will do my first 3-BP + Sal treatment , its time for having a new road

I wish the best for all of you my friends just like I hope the best for my self 🙂

Helga
Member

Hi Emad,

Are they taken before or after TACE? Or one before, one after? How is your mom feeling after the procedure?

Best,
Helga

Emad
Member
Emad

they do MRI before , then CT Scan after

I don’t know if the images are from MRI or CT Scan but it doesn’t really matter , the tumor will not change at all in few hours nor in days

next TACE session they will do MRI and CT Scan again so at that time they will know what did happen with the tumors

my mother felt nauseated for 2 days after the procedure , nothing else , she is fine now

thank you for your concern Helga

I wish for you a long happy healthy life 🙂

Alex
Member

Huge problems there saw the photos. Truly sorry, very bad.
Still i hope in your plans you also incorporate organ support elements. Specially those organs that were affected or are affected by the treatments / tumors.
Take care,
Alex

Emad
Member
Emad

I thought I put a comment , looks like an error happened

Alex
Member

What error?

Emad
Member
Emad

I put a comment but an error happened so I have to type it again

I don’t know if I’m making mistake and if I’m thinking in the right way , but I have some fear of using supplements that could protect the liver , fear that it may protect cancer as well

maybe I’m taking it wrong , but also I feel the best way to protect the liver is to eliminate liver tumors fast

we will do our best to make things better

I hope your dear mother is fine these days , I will pray to hear a good news from you soon

Alex
Member

Thank you i hope for the same in your case.
The neuropathy got worse, i am in doubt about Vitamin B1, i don’t know how to find out if that would help or worsen the situation in my mom’s case.
I can confirm it works better with coffee, DCA i mean. (as in, there is more pain when coffee is drank)
Pain is still there, lymph node is larger and larger…. don’t know exactly what to believe but i am trying to be optimistic.
I guess we’ll find out soon.
Take care, A great weekend to you and our friends
Alex

Emad
Member
Emad

can you please share the dose of DCA and B1 you give to your mother ?

also the other signs like pain and lymph nodes getting larger may not be a sign of disease progression , there is a lot of things that may cause the same thing , so don’t just put in your mind that cancer is progressing

you can’t just think only of the worst scenarios , you need to feel optimistic

wish you always the best dear Alex

Alex
Member

2000mg / day for DCA, but taking a break to lower neuropathy.
No B1 because of uncertainty. (some expression i forgot the name of)…… kill or boost.
We try our best to be optimistic.
Cheers
Alex

Emad
Member
Emad

i don’t know the weight compared to the dose , but its some how near the high dose

not using B1 will help cause neuropathy that’s what i know , I’m always giving it and with high doses , nearly 700mg/kg of B1 every day

Helga
Member

Dear Alex,
I just read that inositol, a cancer-fighting molecule is also good at treating neuropathy! I hope you can look into this and find out more. My internet bytes are running out for now but will be back tomorrow. I hope the best for your mom!

My mother may also suffer from cancer. She feels extremely weak after every meal. Today I prepared her a drink from citric acid and goji berries I ground with coffee grinder plus dried grapefruit pectin, which I also ground. She felt a lot better after drinking it! Goji berries are known to have a strong immune system supporting function and it is a very pleasant tasting drink, I recommend it to you and everyone. Plus, quite cheap and sold at health stores.

Best,
Helga

Wondering
Guest
Wondering

nice summary re inositol, no intention to advertise 🙂

http://us.myprotein.com/thezone/supplements/what-is-inositol-benefits-side-effects/

Ergin
Member
Ergin

Hi Emad,
I dont understand the happenings.Where is mom now?Tace finished?
And what about the results?Stable in 2 days or weeks from CT?

Emad
Member
Emad

my mother did get back 3 days ago , TACE is a small procedure that only took 10 minutes to finish

everything is fine , they determine the effect until the next procedure which should be 4 weeks later

at that time they will do MRI again so they can compare it with the previous one

for now we will continue on systemic chemo like always , maybe in the next week , and until that i will do Sal + 3-BP

aren’t there any new results about your mother ? hope to hear always good news

Emad
Member
Emad

Regarding blood counts (CBC) for my mother :

after 1 week of doing systemic chemo (CMF) , we did CBC test

WBC : 4.5
HB : 10.3
Plat : 145

then she did her first TACE session (chemotherapy used is Mitomycin C and Cisplatin)

after 2 weeks of TACE + few shots 3-BP + Sal , we did CBC test and it shows some decrease in counts

WBC : 4.2
HB : 9.7
Plat : 52

I’m somehow confused , what is most likely the cause of this ?

is it the systemic chemo cause this even when the first week all the counts were in range ?
or TACE may cause this ?
or 3-BP + Sal may help cause this ?

Ergin
Member
Ergin

Dear Emad,
I wish i knew the answer.But your work is wonderful,awsome.
I wonder after 3-BP did you see any side effect?Did you look for blood glucose also?

Emad
Member
Emad

No I didn’t look for the blood glucose

also I can’t notice any side effects , I’m giving her 160mg as IV , and doing my best to let it stable

my protocol now is less aggressive

day 1 : 3-BP
day 2 : nothing
day 3 : 3-BP
day4 : nothing
day5 : Salinomycin
day6: nothing

also when chemo is applied , I’m giving my mother some rest from 3-BP and Sal

also I stopped giving her DCA completely , she hate it because of neuropathy in her legs , even when she know that chemo is the main cause of neuropathy but she refused to take DCA

maybe next month she will do another TACE , if the results were good , then I will stay with my current protocol

if the results is not that good , then I will be more aggressive in using 3-BP and Sal

that’s my plan for now

Ergin
Member
Ergin

Thanks Emad for your answer.I will need your help on how to prepare phlorizin and 3BP.
I only could talk with dr for 1 minutes this week.He said i will not take responsibility with preparing and using phlorizin.
But he will use if we can formulate it.Do you know how to sterilize.The products comes from sigma etc are not steril i think.

Emad
Member
Emad

Hi Ergin

I don’t have that much information on how to prepare phlorizin , I think its documented in the article in this blog

also for 3-BP I’m only doing like Daniel mentioned in the 3-BP article , mix it with sterile water until no powder is visible at all , then pull all the 3-BP solution to the syringe

now the syringe contains the 3-BP solution which is may not be sterile

throw the needle if its used , mount the 0.2 um sterile filter on the syringe , then place a new needle on the other side of the filter , this way we can push the solution inside the NaCl bag , and the solution will go through the filter

the syringe and needles are in every pharmacy , the 0.2 um filter can be easily found on amazon.com , I think Daniel did share the same information with a link to amazon.com on where to get the filter

phlorizin should not be more complicated

Emad
Member
Emad

I have a news that is not good , and its not related to the treatment effectiveness

looks like our chance to get a visa to Germany is very difficult this time

even when we managed to have a financial help from the government , the visa is a big problem that may stop us from continue the other TACE sessions

so frustrating this annoying world is crazy

Alex
Member

Come to Romania, here you get visa easy.
Problem is, getting treatment is unlikely.

Emad
Member
Emad

Sadly its not schengen visa , so it can be only for Romania

I’m interested to go there but only to meet friends like you and Daniel not for treatment 🙂

Emad
Member
Emad

Thank you Daniel you always helping

we will keep this as the final choice, if all the others fail

but for now we have some choices that we can and must try first

best wishes to you 🙂

Helga
Member

Hi Emad,

couldn’t you get a supporting letter from your doctor in Germany to get a visa? What an upside-down world/country (Germany) where they took in a million migrants without any background checks but not you, a law-abiding, educated person with medical needs! Let us know if we can help to write supporting letters. After all, even the bureaucrats are human beings…

Best,
Helga

Wondering
Guest
Wondering

i can help with German translation if needed.

Emad
Member
Emad

We still didn’t do any systemic chemo after TACE done 3 weeks ago

the platelets levels are still very low , also WBC dropped a little bit more !!

when I read some articles about TACE , they talk about chemo is being stuck on liver region for about a month

I don’t know if the chemo is still there and working which is causing a slight drop on blood counts but I can’t understand what is the reason

the only thing I’m doing now for 2 weeks is giving 3-BP and Sal , my mother feels like they are the cause of this
I can’t say no or yes

I sent a message to prof Vogl , still waiting for response regarding this issue

anyone have any idea about side effects like this happening after TACE or Sal or 3-BP ?

Wondering
Guest
Wondering

Hi Emad

Wbc inreasing injections can help instantly, no chance to get prescription?

Emad
Member
Emad

Yes its very easy to manage WBC with this injection , we have it and its always doing the job

but sadly there is no such injection for platelets which is our problem for now , it will take time to improve

do you have any idea on the best way to manage this ?

Wondering
Guest
Wondering

Hi Emad,

I see. I read vit c can help with platelets, you might know this though.

Emad
Member
Emad

No I don’t know about this

I read about it just now after your comment , it looks helpful

I will give it to my mother and it may help

Thanks a lot W 🙂

Ergin
Member
Ergin

An article about antibiotics,its effect is not only infection dependent :

For example, in lung cancers, azithromycin significantly increased 1-year patient survival from 45% to 75%, an ~1.7-fold increase [26]. Interestingly, it was noted that even lymphoma patients that were “bacteria-free” benefited from only a 3-week course of doxycycline therapy, and showed complete remission of the disease [27]. These results suggest that the antibiotic’s therapeutic effects were actually infection-independent.
http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B0%5D=3174&path%5B1%5D=6141

Emad
Member
Emad

very interesting 🙂

Emad
Member
Emad

a very small update

after 1 month of TACE , the blood counts fall down but its improving now and its good

also my mother is feeling stronger and able to do her normal activity just like any normal woman in her age (age 51)

maybe because its been a while since her last systemic chemo

but what is concerning me and make me feel uncomfortable that she is feeling nauseated these days

she used to feel nauseated when she is on chemo , but these days she is not on chemo so why is that ?

is it a bad sign of liver tumor becoming worse ?

feeling nauseated is one of the symptoms of liver tumor becoming more advanced but there is a lot more symptoms like (feeling weak , pain , weight loss and more) and my mother only feels nauseated but nothing else

its weird , I hope its not because of cancer , but what else it could be

Ergin
Member
Ergin

Hi Emad,
Please search for some stomach problems like ulser or bleeding etc.
Anemia causes also nausea.May be she needs hospitalisation.Sorry for giving a negative feeling but this makes you feel better.
Kind Regards
Ergin

Jcancom
Member

Emad, a suggestion: ferumoxytol. It is FDA approved for another indication so could go off label.
A phase 3 trail noted below has already been done that included cancer patients, though no mention appears to be made
about any anti-cancer effects. Another article below talks of how applying a magnet to the skin of mice increased the
response with another magnetic cancer treatment. Best Wishes.

https://med.stanford.edu/news/all-news/2016/09/iron-nanoparticles-make-immune-cells-attack-cancer.html
https://www.nature.com/nnano/journal/v11/n11/full/nnano.2016.168.html
https://www.medgadget.com/2016/10/tumour-associated-macrophage-polarized-anti-cancer-phenotype-ferumoxytol.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4225478/
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5144894/

Emad
Member
Emad

This is interesting and worth trying as its very easy to apply

I thought iron may feed cancer but these studies suggest it may lead to immune response against cancer

I will add it when i make sure that our strategy now is not enough

thank you always Jcancom

also best wishes to you

Jcancom
Member

Emad, there are so many of these approved drugs out there that can be re-purposed.
Reducing metastatic potential could be beneficial.

I hope my suggestions are helpful to you.

https://www.sciencedaily.com/releases/2016/12/161216114145.htm
https://www.nature.com/articles/ncomms13297

Emad
Member
Emad

I wonder why there is not that much statistics on using them with animals , it shouldn’t be that hard to do such test

they are promising and accessible but don’t have much attention

hope to see more news about them soon

of course its helpful suggestion like always 🙂

Ergin
Member
Ergin

We used iv iron and iv sulphur for some months but we didnt see any good responce.

Jcancom
Member

Ergin, the ferumoxytol is a nanoparticle formulation of iron.
It is confusing, though different forms of iron likely have different clinical effects.

Wondering
Guest
Wondering

hi Daniel

one interesting exception is with Arteminisin Annua : then it is important to combine with iron
cheers
W

Wondering
Guest
Wondering

Hi D,
Yeah i agree, i Will post in the forum and if you like it and wish you can repost. Cheers w

Jcancom
Member

Emad, yes it is so frustrating!

Whenever you see these off label results you typically never hear about them again.
There probably are few pharmas that would be willing to spend money on something that is
beyond patents.

You just need to be aware that some of these do not have a marketing department behind them, yet might be of some help.

Emad
Member
Emad

yes it is frustrating

this is our world and how it is functioning unfortunately

Alex
Member

I just wanted to express a personal theory that may very well be wrong. SO PLEASE take this with a big chunk of salt.
“tumor markers are not to be used as an indicator of tumor size but only as an indicator of it outputting antigen in higher or lower quantity, mostly due to slower or faster metabolism”.
Alex

Emad
Member
Emad

I totally agree , its like that

Ergin
Member
Ergin

Alex how is your mom and how are you?
I miss talking with you on skype.
I am lost for some weeks i know.
But i had to do it for myself, a period without searching and far from thinking cancer.
I hope she responded well to chemo.
And i hope you understand me.

Alex
Member

I understand you brother.
It is very hard for my mother and i as well. Life can sometimes seem like a living nightmare sadly. And even more sad is that so many of us go trough this. You know well i can keep on adding.
Soon another chemo cycle, maybe avastin next to it.
To be honest i don’t even know if it’s worth doing the markers or other independent testing, in the end my mom has to feel better, we are in a condition where independent tests won’t do much, she has to get better a bit or more, so far only bad things have happened since her “neuropathy” and i let’s say had a wake-up call that told me to kinda leave things to the “professionals”, i will help as much as i can on the side but the hard truth is that i can’t help with real treatment like an oncologist can.
Still with the incredible help received from Daniel and you, the great advice and people here…… it’s hard to describe the joy and sorrow.
I still hope you and everyone else will experience positive things and maybe even healing. We’re still in the fight, but it got to an almost impossible situation.
I look forward to talking to you again

Our best wishes,
Alex & Mother!

Emad
Member
Emad

Dear Alex and Ergin , my heart is always with you

may God help our mothers to survive this

Vasis
Member

Alex, excellent point about tumor markers! Its even more interesting because part of tumor markers (like CA 15-3) might be produced by leukocytes.

Emad
Member
Emad

Small update

my parents traveled today to Germany for the next TACE

thankfully my father did manage to get the visa for 2 more years for both him and my mother

also managed to get some help from the government to continue doing more TACE sessions

in Friday July 21 at early morning , they will do the second TACE , and they will see the results after 2 months from the first one

I’m a little bit worried , but I hope its fine

I will share the results as soon as it comes

Emad
Member
Emad

New Update :

according to what I did hear from my parents until now that there is 10% improvement since the last time (May-22)

my mother did finish the second TACE

my father will talk with prof Vogl in details

Meech
Member

10% is much better than nothing. Another good thing about it is that the chemo should arrest the growth of the tumours for a period.

After I finished my liver embolization of four tumours from April to August, the November scan showed no new growths. So three months at least I was good. Unfortunately, in March the CT showed six new tumours in the liver, all under 1cm.

If nothing else, it buys you more time to look for more treatments, and that’s always valuable.

Emad
Member
Emad

yes its more about buying time to find better solutions

and indeed its a very valuable time to buy, if things did continue to get worse like before TACE , perhaps my mother wouldn’t made it to now

but with this now we have much more months , we can focus more on what to do next

————

btw , how things going with you after you stop Sef-chemo ? hope you are managing things like you always doing

all the best

Meech
Member

Time is always valuable 🙂 keep the hope.

In general I have been worse since SEF chemo. My hemoglobin hasn’t recovered and it’s been two months. I already have orthostatic tachycardia due to nerve severing during surgery, and having low hemoglobin makes it hard to stand for more than a few seconds or to climb stairs. I have to see about an EPO injection or a transfusion. I developed a slight edema in my left leg, which I assume is from a tumour compressing a vein, but that also makes it a bit harder to walk. I got sick and have been coughing for 3 weeks now so hoping that has nothing to do with the cancer, and I have little aches and pains.

But honestly, I’m in good spirits. I haven’t been hindered from going and seeing friends or being independent, it’s just a mild hinderance and I started the T4 strategy two weeks ago so I’m hoping that’ll shrink things a bit. Thanks for asking!

Meech
Member

Thanks Daniel.

Actually tonight I got a CT scan report of my abdomen and pelvis. I did the scan on Tuesday. The results arent very good. All results compared to March. Developed a multitude of hepatic metastases on virtually all segments of the liver – the largest being 5.4cm. 8cm lymph tumour markedly compressing my left renal artery, which grew from 6.5cm. Potential thrombosis into an iliac vein from a large iliac tumour. 4cm or so mesenteric lymph metastasis grown from 1.5cm or so. And various smaller mesenteric tumours. Fractured ischial tuberosity from a tumour but thankfully no other bone metastases.

Meech
Member

Thanks Daniel. I’m hoping that since my type arises from endocrine cells that the T4 hormone therapy can work something out. Like I said, I still feel fairly good so hopefully there’s still some time to work with.

Emad
Member
Emad

I’m very sorry to hear this Meech

why not to consider other clinic that can do systemic therapy ? like Dayspringcancerclinic or something similar

you may not be experienced on using IVs to treat yourself , but other oral options that maybe interesting to me is T4 strategy and also Methylglyoxal or Thalidomide

I strongly believe that you can overcome this and bring the tumors down like you always did before , I will pray for you to live a happy long life

Meech
Member

Thank you Emad. I am trying the T4 thing so hopefully that’ll work. I’m also considering Dr. Jason Williams in the US, but I have to see if I qualify.

Praying for the best for you as well.

Emad
Member
Emad

I’m happy to hear that you already have a good plan , I hope T4 depletion will do the job

and of course Dr Jason should be one of the best choices for the next

Sincerely
Emad

Wondering
Guest
Wondering

Hi Meech,

Great to see your attitude. How about Mebendazole and Thalidomide? Did you try these?

W

Meech
Member

Thanks for the suggestions, W. I wouldn’t mind trying thalidomide under one of Dr. Hada’s protocols.

Mebendazole, although I’m sure has an effect, I’m not 100% sold on as being right for me. I’m in a private FB group where most members are taking a protocol which include some mebendazole. I asked if anyone has seen any shrinkage or if everyone has basically just helped to slow their growth or stabilize things and nobody came forward saying they had shrinkage. But for most, stabilization and slowed growth rate are definitely important. For me though, I do need to shrink thing’s as the status quo isn’t great.

Jcancom
Member

Emad, I am so happy for you!
TACE seems like a great procedure.

Emad
Member
Emad

Hi Jcancom

thank you always for your feelings , I should be happy that you are always here with us , and especially helping me a lot

unfortunately can’t be happy for now , I’m worried about my brothers Alex and Ergin , no way to feel happy until their mothers feel better , also the same for Pouya I wish he feels better one day soon

this is the world with cancer , we should do our best before time is up

——————-

regarding the results after TACE , I did administrate 15 3-BP IV and 7 Salinomycin IV for the past 2 months , it seems like either TACE is not working well or (3-BP + Sal) is not , or maybe both have minimal effect , not very sure

I can’t know which one is really working , and I can’t be sure until we stop one of them

Ergin
Member
Ergin

Dear Emad,
May be it is not a miracle but it gives you lots of months to try other treatments.
Stable is also a good thing for us.Thats not we want ofcourse but we must think like that.
For me,you did a great job.And you will.

Emad
Member
Emad

Thank you always Ergin

I wish if I can help you just like how greatly you are helping me

we did face a hard times , but will not stop doing new things and new strategies until we both save our mothers

ALBERTO
Guest
ALBERTO

Dear All, I would like to share good news. Marker CA125 drop to normal after 2 cycles of Taurolodine. We got our aim: to start the vaccine cocktail under normal condition. I will update with or experience in Germany.

Best wishes
Dr A Hernandez

Ergin
Member
Ergin

Dear Dr Alberto,
Thank you very much for sharing the results with us.Very good news thanks.
Kind Regards
Ergin

Emad
Member
Emad

Excellent news Dr Alberto

really i need to understand more about the protocol you did

hope to always here good news from you

ALBERTO
Guest
ALBERTO

Hi Emad
I have already wrotten before but in summary, my sugestions are:
Do a sensitivity test, so you can use the most active substances against the tumor.
iv is the better route. Do the therapy in cycles.
be aggressive but always always use the right substance. Not which is good for one person is good for another one.
In our case, we did the sensitivity test, and try to give iv the substances more active. We did a molecular study with the NEw generation system, and we developed an specific vaccine for our specific mutations. Then leave your body to kill the rest of the cells. Avoid chemo and radiotherapy when possible, the vaccine is not effective during this therapies because your immune system is to weak.
Best

Emad
Member
Emad

thank you so much Alberto

one more question , did you test for Taurolodine before to see if its effective ?

also is it possible to share the source that you did use ?

always wish to hear good news from you

Kind regards

Alberto
Guest
Alberto

HI Emad, yes we tested before the sensitivity, there r different companies as Maintrac, Bojar, in Germany and also in Greece there is a famous one. Pick it up one and do it, do not work blind.
Best wishes

Emad
Member
Emad

Hi dear friends in this website, I miss you all

sorry for not being around too much these days , the internet connection and electricity is almost off most of the time these days in Libya

Last update : the results after second TACE are better than the first one

and what we did is : TACE + Sal + 3-BP, no systemic chemo

the past 2 cycles are done in the right side of the liver , but this time prof Vogl decided to treat the left side of the liver

i don’t know if its normal but this time it was very painful , my mother have severe pain these days , and sometimes make her faint

prof Vogl said that its temporarly , and prescribed some medications to lower the pain , i noticed the pain is slowly decreasing , but still she feels a bad pain in the target position and also in her back

regarding the treatment plan , i don’t understand why prof Vogl believes that we are doing good and don’t need more than 1 or 2 other TACE sessions

but in anyway , we did reach the limit of receiving help from government , its hard to continue do more than that

so the next big fight will be after we finish TACE , trying to manage the disease with hormonal therapy + others like Sal + 3-BP …

that’s all I have now, wish you all the best

Hectoria
Guest
Hectoria

Hi Alberto,
What kind of treatment are you having in Germany. Is it a vaccine made from blood? Also, I would be most interested to hear about your wife’s experience, both with taurolidine and with the vaccine and treatment in Germany. This is something I considering too and would love to hear how it went. Thanks..

Alberto
Guest
Alberto

Hi, we did from the Parafin tumor sample. Vaccine is ready, so we start treatment next month. WBW

Ergin
Member
Ergin

I am very happy that my name is not Alberto.
https://youtu.be/BGBM5vWiBLo

Ergin
Member
Ergin

Tomorrow i ll give you a link about a chemo sensitivity test.Everything ll be clear for all.

Ergin
Member
Ergin

Please Alberto,
Do not play with our senses.Do not try to be popular.Look how Emad tries to save moms life.It is not a game.He began MG,not a joke.
Be a man like a MAN like Daniel.
Be brave.
Make me to apologise from you in this website
Do not talk like a puzzle please.

ALBERTO
Guest
ALBERTO

What are you talking about? why you are talk to me on this way?

ALBERTO
Guest
ALBERTO

Ergin, I will inform Daniel about your behaviour. Its completely inapropiate

Ergin
Member
Ergin

Off Dear Alberto,
I mixed Your name with Halabe.
I am very sorry about this.I respect you and your work too much ofcourse.
When i see his name on Emad ‘s page i totally became a different person.

Emad
Member
Emad

A little update : I stopped Salinomycin and 3-BP temporarily , and now I’m giving my mother Methylglyoxal orally about 23mg/kg

I want to see if there is any difference in results , and will turn back to Sal + 3-BP after the forth TACE session

Wondering
Guest
Wondering

fingers crossed, Emad!
do you have info on the marker after each chemo session ?

Emad
Member
Emad

no , we didn’t do any marker test for months

maybe after the next session we will do one , we will do it if its the last TACE session

no need for it now while we are doing MRI

Ergin
Member
Ergin

Hi Emad,
How are you and mom?I hope you saw some good responces with MG.
Did you observe any side effect?
Our chemo sensitivity test came.I lost my faith on that test.Please do not think you are loosing stg if you dont do that test.
I will send you by mail.If anyone interested ,i can send it.
Best wishes
Ergin

Emad
Member
Emad

Hi Ergin

My mother is fine these days , we still didn’t notice any side effects from MG

also like when using 3-BP and Sal , we don’t know if the response is due to them or due to TACE or due to the both

we didn’t do any tumor marker test for months , we are just following up with MRI before every TACE cycle

but why you lost faith on the test ? I thought its good to have one for my mother too

I hope the results are reliable

Alex
Member

i’m interested brother,
send me.
my mother is now in hospital for chemo and other paralisys problems
Tarceva seems to be doing something good next to the side effects but nothing very dramatic so far.
Little to no cancer pain and some nervous recovery on her chest.
take care bro
Tell me if i can help.
Alex

Emad
Member
Emad

Hi Alex , great to hear that pain is reduced and there is nervous recovery

I wish to hear better news in coming days my friend