About two years ago, I wrote an article on Citric Acid (CA) and it’s potential as an anti cancer agent (Ref.). There was a lot of debate on this subject, reflected in nearly 1000 comments on the post. We’ve seen some strong opinions pro and some strong opinions against this subject, some more and others less scientifically based, some more and some less fact based.
This debate made me to strongly question this cancer fighting approach and it’s effectiveness.
As you know, I am doing my best to keep my posts as objective as possible, and fact based. But the reality is that next to logic the oncology world is full of emotion, which affects me too and in turn it may affect my view on various treatment approaches. This is the moment when I like to go back to science and use that to sharpen my view on the specific subject.
Speaking of scientific evidence that can help us sharpen our views, yesterday I became aware (thank you Dr. Alberto for the heads up) of a recent scientific paper published in the second half of 2017, in the journal Scientific Reports of Nature Group. This paper is reporting work on Citric Acid performed at Harvard School of Medicine, and concluding the following: “Our data suggests that citrate can inhibit tumor growth in diverse tumor types and via multiple mechanisms. Dietary supplementation with citrate may be beneficial as a cancer therapy.” (Ref.). Given the fact that this work was performed by a world leading medical school including an author that I very much trust, I see this as an important support for the work of Dr. Alberto Halabe Bucay, previously reporting response in various cancer patients (see Ref.).
Given it’s low cost, accessibility and ease of implementation, I think this treatment approach may be relevant to those cancer patients that are left with no other options and/or can not afford other cancer treatments. However, I would not give up more powerful treatment approaches, such as the one used by Marcos here (Ref.) vs switching on CA. Instead, I would use it when no other options are available or when the patient if off-treatments due to various reasons.
You can find my earlier post on Citric Acid here: (Ref.)
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3-BP and citrate synergize
PMID: 22318356
Sorry if this is a silly question! 🙂 But when you say Citrate, does HCA or Hydroxy Citrate fall into that camp? I have to admit, I’m a bit confused about Citric Acid, Citrate, and HCA differences. Thank you!
Hi Leora.
No question is silly. Only the answer can be 🙂
1. HCA vs CA have different mechanism relevant to cancer. I wrote about both mechanisms in details here https://www.cancertreatmentsresearch.com/another-weak-spot-of-many-cancer-cells-atp-citrate-lyase-inhibition/ and here https://www.cancertreatmentsresearch.com/citric-acid-inhibits-fermentation-and-kills-cancer-in-humans/
HCA inhibits the enzyme responsible for conversion of Citrate into acetyl-CoA.
2. Difference between Citric Acid and Citrate https://www.researchgate.net/post/Is_there_any_difference_between_citric_acid_and_citrate_in_citric_acid_cycle
(Same as between Bromopyruvic Acid and Bromopyruvate)
Hi Daniel,
Do you know or maybe the good Dr. Alberto can answer, if you are taking Citric Acid do you have to take it for the rest of your life? or just until you have no disease left?
Thanks again!
Dear Kamel,
as long as there is tumor response, I would take it for some time after reaching complete response. It’s also good to cycle treatments so probably I would do some brakes as well, while having an eye on marker development. However this is just my oppinion. It’s best to address this question to dr. Alberto, as a reply to one of his comments so that he receives a notification.
Kind regards,
Daniel
I read the previous post on CA, and I can certainly understand why dr. Alberto isn’t responding. The language barrier didn’t help either. The thing is, if a MD, like dr Alberto, threats a cancer patient with one single agent and they see a complete response, they call that a cure. Of course they know it’s not a cure for all cancers, but that particular agent proved to be the cure for that particular cancer. Hence, cure for cancer. It’s important to appreciate this difference. I’ve seen it with Burzinsky too. His antineoplastons are indeed a cure for cancer, just not all cancers!
Kudos to you Daniel, for your ability to moderate these incredibly emotional discussions.
I ment “treat” not “threat” LOL
Hi Johan – can I ask if you could provide website contact for Dr. Alberto?. What particular cancer and what particular single agent did Dr. Alberto used to cure this particular cancer?.
Hi Westie,
“Remission of multiple myeloma after receiving only citric acid orally (Alberto Halabe Bucay)”, contact information is in that case report.
Thank you Johan. That was a challenging time indeed … only latter I learn (in private) that one of the contributors (that was also a caregiver) had serious challenges that were reflected into a highly volatile opinion and communication style (but a man with a good heart otherwise).
Daniel there’s an antacid called Sal de uvas picot that contains tartaric acid, citrate 1.9gr and sodium bicarbonate… https://www.picot.com.mx/sal-de-uvas-picot/
Would there be any reason why adding more citrate to this mixture would impact citrate’s absorption?
I am not sure about this Yudaitheska. I would need to investigate before being able to answer the question.
Kind regards,
Daniel
Hi Daniel, & Dr Alberto.
My mother is on ; daily febendazole- panacur c, full for the spectrum CBD, tumeric for the past two months ,and mebendazole 100mg x2 daily, for Meyloid Leukaemia. Also is getting Azacitadine CH chemo injections into into stomach 7 days in a row, and approximately 2 weeks off.
My question relates to Citric acid, I am assuming it is the “baking” ingredient substitute.
Is it ok to take the Citric Acid while taking these Azacitidine shots ?
Many thanks
Dear CZA,
I am not aware of any interaction between CA and Azacitidine, but it is best that you study the literature related to this specific case. You can also post a question to Dr. Alberto by replying to one of his messages here https://www.cancertreatmentsresearch.com/citric-acid-inhibits-fermentation-and-kills-cancer-in-humans/
Kind regards,
Daniel
I want to ask if DCA inhibits pyruvate dehydrogenase kinase and reactivates pyruvate dehydrogenase and alpha lipoic acid does probably the same then we (at least in theory) shouldn´t take citric acid with ALA too.
However, how good is the science behind citric acid inhibiting pyruvate dehydrogenase in cancer cells?
Targeting citrate as a novel therapeutic strategy in cancer treatment
https://www.sciencedirect.com/science/article/pii/S0304419X19301593
“An important feature shared by many cancer cells is drastically altered metabolism that is critical for rapid growth and proliferation. Citrate is a key metabolite that bridges many important metabolic pathways. Manipulating the level of citrate can impact the behaviors of both cancer and immune cells resulting in induction of cancer cell apoptosis, boosting immune responses and enhanced cancer immunotherapy. We summarize the molecular basis of altered citrate metabolism in both tumors and immune cells, explore the seemingly conflicted growth promoting and growth I hibiting roles of citrate in various tumors and highlight the new development of combining citrate with other therapeutic strategies in cancer theraphy”
CZA says:
AUGUST 24, 2021 AT 12:05 AM
Hi Daniel, & Dr Alberto.
My mother is on ; daily febendazole- panacur c, full for the spectrum CBD, tumeric for the past two months ,and mebendazole 100mg x2 daily, for Meyloid Leukaemia. Also is getting Azacitadine CH chemo injections into into stomach 7 days in a row, and approximately 2 weeks off.
My question relates to Citric acid, I am assuming it is the “baking” ingredient substitute.
Is it ok to take the Citric Acid while taking these Azacitidine shots ?
Many thanks
Forgot to add that she is on Tranexamic acid tablets for blood clotting every night.
Will the citric acid interfere with that ?
“El paciente que se curó con ácido cítrico”
https://www.sdpnoticias.com/opinion/alberto-halabe-el-paciente-que-se-curo-con-acido-citrico/