Update on Citric Acid & Cancer

About two years ago, I wrote an article on Citric Acid (CA) and it’s potential as an anti cancer agent (Ref.). There was a lot of debate on this subject, reflected in nearly 1000 comments on the post. We’ve seen some strong opinions pro and some strong opinions against this subject, some more and others less scientifically based, some more and some less fact based.

This debate made me to strongly question this cancer fighting approach and it’s effectiveness.

As you know, I am doing my best to keep my posts as objective as possible, and fact based. But the reality is that next to logic the oncology world is full of emotion, which affects me too and in turn it may affect my view on various treatment approaches. This is the moment when I like to go back to science and use that to sharpen my view on the specific subject.

Speaking of scientific evidence that can help us sharpen our views, yesterday I became aware (thank you Dr. Alberto for the heads up) of a recent scientific paper published in the second half of 2017, in Nature magazine, one of the most prestigious and high impact magazine. This paper is reporting work on Citric Acid performed at Harvard School of Medicine, and concluding the following: “Our data suggests that citrate can inhibit tumor growth in diverse tumor types and via multiple mechanisms. Dietary supplementation with citrate may be beneficial as a cancer therapy.” (Ref.). Given the fact that this work was performed by a world leading medical school and published in a world leading scientific magazine, I see this as an important support for the work of Dr. Alberto Halabe Bucay, previously reporting response in various cancer patients (see Ref.).

Given it’s low cost, accessibility and ease of implementation, I think this treatment approach may be relevant to those cancer patients that are left with no other options and/or can not afford other cancer treatments. However, I would not give up more powerful treatment approaches, such as the one used by Marcos here (Ref.) vs switching on CA. Instead, I would use it when no other options are available or when the patient if off-treatments due to various reasons.

You can find my earlier post on Citric Acid here: (Ref.)


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6 thoughts on “Update on Citric Acid & Cancer

  1. Sorry if this is a silly question! 🙂 But when you say Citrate, does HCA or Hydroxy Citrate fall into that camp? I have to admit, I’m a bit confused about Citric Acid, Citrate, and HCA differences. Thank you!

    1. Hi Leora.

      No question is silly. Only the answer can be 🙂

      1. HCA vs CA have different mechanism relevant to cancer. I wrote about both mechanisms in details here https://www.cancertreatmentsresearch.com/another-weak-spot-of-many-cancer-cells-atp-citrate-lyase-inhibition/ and here https://www.cancertreatmentsresearch.com/citric-acid-inhibits-fermentation-and-kills-cancer-in-humans/
      HCA inhibits the enzyme responsible for conversion of Citrate into acetyl-CoA.

      2. Difference between Citric Acid and Citrate https://www.researchgate.net/post/Is_there_any_difference_between_citric_acid_and_citrate_in_citric_acid_cycle
      (Same as between Bromopyruvic Acid and Bromopyruvate)

      1. Hi Daniel,

        Do you know or maybe the good Dr. Alberto can answer, if you are taking Citric Acid do you have to take it for the rest of your life? or just until you have no disease left?

        Thanks again!

        1. Dear Kamel,

          as long as there is tumor response, I would take it for some time after reaching complete response. It’s also good to cycle treatments so probably I would do some brakes as well, while having an eye on marker development. However this is just my oppinion. It’s best to address this question to dr. Alberto, as a reply to one of his comments so that he receives a notification.

          Kind regards,

  2. I want to ask if DCA inhibits pyruvate dehydrogenase kinase and reactivates pyruvate dehydrogenase and alpha lipoic acid does probably the same then we (at least in theory) shouldn´t take citric acid with ALA too.
    However, how good is the science behind citric acid inhibiting pyruvate dehydrogenase in cancer cells?

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