Treating Ascites with Angiogenesis Inhibitors

Malignant ascites are side effects of some cancers (and potentially anti-cancer treatments), characterized by the accumulation of fluid in the abdomen.

Recently, I have received from a friend this article on ascites (from epithelial ovarian cancer), and thought is a good idea to share this here: Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675660/#SD1

According to this article, I understand that effective treatments against the ascites are focused on angiogenesis inhibition addressing the following:

1. VEGF inhibition

2. inhibitors of the tumor-promoting tumor-associated macrophages (TAM) commonly designated as “M2”

Here are some VEGF inhibitors I know (besides the conventional ones): Baicalein, Noscapine, Mebendazole, Albendazole, Celcoxib, Shark Cartilage, Thalidomide, Curcumin

Here is a nice reference for Albendazole:  Albendazole: a potent inhibitor of vascular endothelial growth factor and malignant ascites formation in OVCAR-3 tumor-bearing nude mice.http://www.ncbi.nlm.nih.gov/pubmed/16551879. The only drawback related to Abendazole is the liver toxicity. On the other hand I know a cancer patient who is taking it for a long time with no major issues.

Mebendazole is on the other hand one of my favorites.

Thalidomide is another VEGF inhibitor I specifically like. I intend to write a post on Thalidomide only, but for now here are few words about it: Thalidomide has been shown to be potent in inhibiting tumor necrosis factor (TNF)-α, IL-1, IL-12, and VEGF in addition to IL-6, and can stimulate T cells via its interaction with cereblon 10,11. It has been also demonstrated that thalidomide is capable of decreasing IL-6 levels, lowering C-reactive protein, and, thereby, inducing remission in MCD. Ref:  Thalidomide for tocilizumab-resistant ascites with TAFRO syndrome http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498865/

Regarding the inhibition of M2, I wrote sometime ago an article on my page http://www.cancertreatmentsresearch.com/?p=265

Note:  M2 responses are associated with growth factor production (e.g., VEGF or EGF) http://journal.frontiersin.org/article/10.3389/fimmu.2015.00212/full#F1 so inhibiting growth factor production would have inhibiting impact on M2 response.

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

Related Articles


Leave a Reply

22 Comments on "Treating Ascites with Angiogenesis Inhibitors"

avatar
  Subscribe  
Notify of
Fred
Member
This is helpful Daniel. Always disturbing to see a promising drug, mebendazole discontinued (no reason given) and unavailable in the U.S. The following suggests Albendazole/mebendazole should be explored: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/ Albendazole or other benzimidazole: There is evidence that the different benzimidazoles vary in their molecular targets and that combining them may improve efficacy and reduce the risks of acquired resistance. While this approach has not been explored in a cancer setting, there is pre-clinical and clinical evidence that the combination of MBZ and albendazole is a more effective treatment in certain hard to treat parasitic conditions [8, 9]. There is also… Read more »
Fred
Member

I was able to order Thailand Mebendazole in 100mg (Vermox) and 500mg (Benda) packages. The downside is it takes 2 or 3 weeks. I don’t think the shipment will run into import problems but I’ll let you know.

Fred
Member

Daniel, both Vermox and Benda came in from Thailand with no delays. We started with Vermox 100 and have moved to Benda 500 (+cimetidine), 1x/day. Is your wife taking it daily or # times per week?

Fred
Member

“… Carbamazepine and phenytoin lower serum levels of mebendazole. Cimetidine does not appreciably raise serum mebendazole (in contrast to the similar drug albendazole), consistent with its poor systemic absorption. …”

http://research.omicsgroup.org/index.php/Mebendazole

madama
Member

hi all,

do you think it can be problematic if we take thalidomide and albendazole together?

madama
Member

hi daniel

i m going thru contact in countries where this is available at cheaper price.

i could help people to get it if needed

thanks

Hanh
Guest

Hello, I would like to get this med. for my husband. Did you be able to find a source. Thank you.
Hanh

alternmed
Guest

hi hanh

this is madama

please contact me thru pm at cancercompass ,my nickname is alternmed there.

i m trying to post using my nickname madama,but the website is blocking me

thanks

Hanh
Guest

Thank you, my husband situation was taking a turn for the worse after 1 week on Stivarga. His bilirubin shot up, his tumor marker shot up.
His oncologist pushing for hospice. I am not confident in self treatment not when his condition is this critical. So we went to an integrative clinic
Hopefully this doctor can turn thing around. I would ask for your help once his stiuation is stable.
Thanks,

Masato Hada
Guest

To Mr Daniel
The effective treatment of ascites is to use VEGF inhibitors, I think the combination of thalidomide, celecoxib and low dose cytotoxic drug is essential.
In order to eradicate H.pylori, proton pump inhibitor and antibiotics must be combined.
It is impossible to eradicate with proton pump inhibitor or antibiotics alone.
Masato Hada

Reference ReseachGate
Report of two cases with pleural effusion and ascites that responded dramatically to the combination of thalidomide, celecoxib, irinotecan, and CDDP infused in thoracic and abdominal cavities.

Masato Hada
Guest

To Mr Daniel
The eradication of H.pylori is nothing to do with the treatment of ascites at all. This is metaphor.
My expression and English were bad, sorry. I would like to say that PPI only or antibiotics alone could not eradicate H.pylori. Like the eradication of H.pylori , to prevent the accumulation of ascites, cytotoxic dug only or targeted drug alone is not effective. I would like to say that the combination of proper drugs is very important.
Masato Hada

Emad
Member

There is something strange these days

my mother is improving very fast , but also it looks like ascites is increasing !!!

I don’t know how something like this could happen , good and bad at the same time

I contacted prof Vogl , he said that we should treat the cancer to eliminate ascites

and he didn’t prescribe any drugs to help reduce it

——-

I don’t have thalidomide , I don’t know is it ok to let the ascites increase without using diuretics ? or its better to treat it before it increases even more ?

Ergin
Member

Treating ascites with diuretics is not impossible.
But less chance.If you ll use , please look
for blood pressure and blood counts.
Dapagliflozin is also diuretic.

Ergin
Member

And most important,you have to know CRP!.
Inflamation!?
And albumin,iron,thyroid levels for embolism.

Ergin
Member

Avastin works perfect for some patients,i know it is very expensive.
We talked with Dr Hada about comparison thalidomide and avastin a year ago.
He said thalidomide has less side effects.
When i look gene sequencing results of lots of patients,i saw thalidomide is not effective to all.
Thats why i did not use it.But now i am thinking different.It is a good drug should be think to try.