Malignant ascites are side effects of some cancers (and potentially anti-cancer treatments), characterized by the accumulation of fluid in the abdomen.
Recently, I have received from a friend this article on ascites (from epithelial ovarian cancer), and thought is a good idea to share this here: Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in Late-Stage Epithelial Ovarian Cancer http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4675660/#SD1
According to this article, I understand that effective treatments against the ascites are focused on angiogenesis inhibition addressing the following:
1. VEGF inhibition
2. inhibitors of the tumor-promoting tumor-associated macrophages (TAM) commonly designated as “M2”
Here are some VEGF inhibitors I know (besides the conventional ones): Baicalein, Noscapine, Mebendazole, Albendazole, Celcoxib, Shark Cartilage, Thalidomide, Curcumin
Here is a nice reference for Albendazole: Albendazole: a potent inhibitor of vascular endothelial growth factor and malignant ascites formation in OVCAR-3 tumor-bearing nude mice.http://www.ncbi.nlm.nih.gov/
Mebendazole is on the other hand one of my favorites.
Thalidomide is another VEGF inhibitor I specifically like. I intend to write a post on Thalidomide only, but for now here are few words about it: Thalidomide has been shown to be potent in inhibiting tumor necrosis factor (TNF)-α, IL-1, IL-12, and VEGF in addition to IL-6, and can stimulate T cells via its interaction with cereblon 10,11. It has been also demonstrated that thalidomide is capable of decreasing IL-6 levels, lowering C-reactive protein, and, thereby, inducing remission in MCD. Ref: Thalidomide for tocilizumab-resistant ascites with TAFRO syndrome http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4498865/
Regarding the inhibition of M2, I wrote sometime ago an article on my page http://www.
Note: M2 responses are associated with growth factor production (e.g., VEGF or EGF) http://journal.frontiersin.org/article/10.3389/fimmu.2015.00212/full#F1 so inhibiting growth factor production would have inhibiting impact on M2 response.
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