Tips on Treatments: A List to be Constantly Updated

There are various very important aspects that emerge during our many discussions here, that are finally lost while I find them very valuable. As a result, I created this list in order to make sure we do not loose them. This is a list that will be alive and evolve:

 

 

  • Using antiparasites/antibacterials prior to chemotherapy or other therapies
    Some scientists across the world argue that tumors, specifically those of lungs but not only, may develop various bacteria/parazites that can lead to treatment resistance. Very recently, a breakthrough paper published in Science magazine is demonstrating exactly this fact: Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine http://science.sciencemag.org/content/357/6356/1156 (Thanks Jandro for pointing this out). In line with this research, I would always consider using antiparasites (example Ivermectin) and/or antibiotics (e.g. Doxycicline) prior to a major anti cancer treatment.
    .
  • Stop any (alternative or not) treatment that can slow down cancer cells prior to chemotherapy
    It is well know that many of the chemo therapies are more effective in fast dividing cells. A recently published PhD thesis (Ref.) demonstrated that using drugs effective in slowing down tumor development (such as Metformin) may be good as it slows down cancer but is NOT suitable when those drugs are taken a few days prior to chemo, as they may make chemo less effective. Instead, the same work demonstrated that if Metformin is stop for a few days before chemo and is added starting with exactly the same day of chemo,  the chemo effectiveness increases. I expect the same rule should apply to other therapies that have the potential to slow down cancers: i.e. stop that treatment 3-4 days prior to chemo, and start again the same day with chemo.
    .
  • Cimetidine is a great anti-metastasis off-label drug, but it may make some conventional treatments ineffective
    Indeed, Cimetidine is often used at clinics across the world as an anti mets drug. I do strongly believe in its potential. We did used Cim for about 3 years and I believe it is a major reason why we succeeded to keep a very aggressive cancer confined for all these years to the initial locations where it was first detected. Here is more about Cim potential (Ref.) However, due to its impact on specific enzymes responsible for drug metabolization, Cimetidine may reduce or increase plasma level of specific substances. For example, some hormonal treatments used to treat breast cancer patients, in order to be effective they need to be metabolized first, which will not happen if Cimetidin (or e.g. grapefruit juice) is used. Therefore, prior to use Cimetidine patients should discuss with their medical doctor potential interactions with current medication. The interactions between drugs can also be checked here http://reference.medscape.com/drug-interactionchecker?src=google
    .
  • Inflammation is essential for cancer development and any effective anti cancer strategy should address this aspect with anti inflammatory drugs and/or supplements, specifically prior to a surgery
    Here is a nice video shared sometime ago by Meech which I find extremely valuable and should be viewed by anyone considering a surgical intervention https://www.youtube.com/watch?v=H8zVrYEW8vE&feature=youtu.be
    .

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

Please read an extended version of the Disclaimer here: http://www.cancertreatmentsresearch.com/?page_id=1794

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59 thoughts on “Tips on Treatments: A List to be Constantly Updated

  1. Excellent initiative Daniel! I have noticed your comments in the Forum regarding avoding Metformin before chemo. This is really interesting and I really would like to read the paper. I haven’t been able to find it myself so it would be great if anyone could provide a link

    1. Thnaks Carl! I just found the PhD thesis. It was done on colorectal cancer cells. Here is a quote from the abstract:

      “When I combined the biguanide with the chemotherapy drugs commonly used to treat CRC I observed different responses in the cell lines analysed that reflected their genetic background and their different sensitivities to both the biguanide and chemotherapy. I found that metformin added before chemotherapy drugs antagonised their effects in the majority of the treatments. On the contrary, its administration after long chemotherapeutic treatments significantly reduced the cell viability. I noted that metformin better inhibits cell proliferation in cell lines with rapid growth.”

      And here is the complete thesis: http://oro.open.ac.uk/49296/1/PhD%20thesis_%20Maiorana.pdf

      There are different results, depending on different combinations and cancer cell type but the above quote covers well the results.

      1. Thanks Daniel! I found a study that discusses the antagonistic effect of Metformin on Gastric cancer cells. It concludes though that that the effect may vary dependant on cell type and possibly also the type of cancer.
        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4305376/

        Metformin is undetectable in blood plasma within 24 hours of a single oral dose. Do you have any thoughts on how long it may take before the (possible) antagnostic effect diminishes?

  2. One thing re: the talk that I posted on the forum.

    While treating my tumours with ablation, Dr. Williams uses a slew of anti-vascular and anti growth factor drugs in the procedure. He also uses ketorolac, like Dr. Sukhatme recommended for surgery. So it may be of benefit for more than just surgery.

  3. A warning on antibiotic usage: they don’t kill just the pathogenic bacteria, which may be responsible for chemo resistance, but also the probiotic bacteria. And probiotic bacteria may be quite useful, in combination with some chemo.
    Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model.
    https://www.ncbi.nlm.nih.gov/pubmed/26125762
    So my advice is to avoid antibiotic use during chemo, besides the killing of useful bacteria, they may interfere with the cell cycle, and possibly antagonize chemo.
    I guess the optimal treatment would be antibiotics before chemo (stop at least 24h before), and then rebuild the microbiota with probiotics (some of them secrete substances with potent activity against cancer). And diversity of the probiotics matters, for the stimulation of the immune system. Quantity should be moderate, some commercial packages of probiotics are just overdoses IMO, they can damage the liver and pancreas.
    Since Doxycycline was mentioned, and it has anti-cancer properties (against hypoxic cancer stem-like cells), I must also warn that Doxycycline causes intestinal inflammation and irritation (after about 10 days of use at normal dose).
    Doxycycline Promotes Carcinogenesis & Metastasis via Chronic Inflammatory Pathway: An In Vivo Approach.
    https://www.ncbi.nlm.nih.gov/pubmed/26998758

    1. Thanks Ovidiu for this valuable addition. I agree, that is the well known drawback when using antibiotics. I also touched this subject in the following article https://www.cancertreatmentsresearch.com/gut-bacteria-amplifies-immunotherapy/
      On the other hand it offers the advantages discussed above + the Doxy anticancer effects are well known, e.g.
      – Antibiotics that target mitochondria effectively eradicate cancer stem cells, across multiple tumor types: treating cancer like an infectious disease. https://www.ncbi.nlm.nih.gov/pubmed/25625193
      – Doxycycline Vitamin C Anti Cancer Synergy http://jeffreydachmd.com/2017/06/doxycycline-vitamin-c-anti-cancer-synergy/
      Targeting hypoxic cancer stem cells (CSCs) with Doxycycline: Implications for optimizing anti-angiogenic therapy http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18445&path%5B%5D=59280
      – Studies on antitumor activity spectrum of doxycycline http://www.sciedupress.com/journal/index.php/jst/article/viewFile/8809/5529
      http://www.sciencealert.com/this-is-big-common-antibiotics-can-also-kill-off-a-range-of-cancer-cells
      https://www.ncbi.nlm.nih.gov/pubmed/28270076
      – Doxycycline attenuates breast cancer related inflammation by decreasing plasma lysophosphatidate concentrations and inhibiting NF-κB activation https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-017-0607-x
      – Doxycycline Induces Apoptosis in PANC-1 Pancreatic Cancer Cells http://ar.iiarjournals.org/content/29/10/3995.full
      and so on ….

      The anti cancer effect of Doxy I find more relevant when fighting advanced cancers vs. the risk of Carcinogenesis from the last reference in your comment, which is a more relevant effect to consider and avoid when someone doesn’t have cancer.
      Beyond these more theoretical advantages and disadvantages, which everyone should consider for own case, I did found Doxy very helpful to address complications from lung mets. and as a result Doxy represented a helpful “tool” during our fight.

      But to be clear, I also do not like the negative impact on antibiotics on immune system … so is good to be aware about potential advantages and disadvantages.

  4. Hi Daniel , I have to say something regarding the second point (on stopping any (alternative or not) treatment that can slow down cancer cells prior to chemotherapy)

    in the past I used to give a lot of DCA before 24 hours of chemo , and I felt like the chemo was always effective because of that , and for one time I stopped DCA for about 4 days of giving chemo , at that time the chemo didn’t have any effect , but also at that time I didn’t give DCA even after a week of the chemo

    I’m not sure what was happening , could be that DCA should have stronger effect if I use to give it after and not before chemo ? or DCA is not slowing the cancer but making it less resistant to chemo ? or maybe DCA is doing far damage to cancer cells which makes chemo kill them easily even when they are slow ?

    at the end I didn’t try to give DCA with and after chemo instead of giving it before chemo , I miss that chance to try this strategy

    at then end I hope we will never need this , as we are planning to shift to hormonal therapy after TACE , and of course will use 3-BP and Sal or MG with it , hormonal therapy are daily pills so I think there is no specific strategy could be considered with it

    just hope it could work and let the liver tumors stay where they are and not becoming bigger

    cimetidine and hormonal therapy interaction is a very helpful thing to know about it especially now , thanks for these great tips , they are very helpful

    1. Hi Emad,

      Your question is very fair. If is to compare DCA with Metformin, actually Metformin’s major action is expected to be related to the slow down of the mito function. With that energy production and Citric Acid production in turn required for producing some major building blocks used in the fast cellular division. This should indeed act mainly through what we here call “slow down” of the fast division which should not be beneficial when combined with treatments that actually are focused on attacking fast dividing cells. But it should help those treatments once they start attacking the cancer cells, since it Metformin will lower the energy production which is also used to fuel the cellular pumps used to push out chemo.

      In contrast to that, DCA should actually increase mitochondria function, and with that ROS generation. This should not slow down cancer cells activity but maybe temporarily even slightly increase the activity (my speculation – I do not have a reference here) but create a pro-oxidant pressure which if it is high enough can kill cancer cells. If the cancer cells are not killed, at least you temporarily reduce their anti oxidants level (which is typically used to fight the increased ROS production due to an increased activity of mito, facilitated by DCA). Now, if in this context you push chemo inside the cell, which is also a pro oxidant “tool”, there is a higher chance for chemo to do its work as the anti-oxidant level is already reduced due to prior use of DCA.

      That is my understanding, Emad, regarding the difference between the two, i.e. Metformin and DCA in combination with chemo, and why you saw improved results when using DCA prior to chemo.

      This also means that in order to make best choices, we need to try understand the major mechanisms related to the supplements and drugs we are using. We may never know everything, but understanding more about the mechanisms should help increase our chance of success – and finally more people can reproduce it.

      Kind regards,
      Daniel

      1. Thank you Daniel , Excellent explanation , you may not be 100% sure but it makes sense and made things more clear

        basically we need to always know about if a certain treatment is lowering down the cancer or not before we use it prior to chemo

        the cancer is indeed a real puzzle , but we are also learning new things everytime 🙂

    1. You know Ergin, cana and dapa , block sugar intake in kidney, this could increase osmotic filtering increasing renal function and decreasing bioavility of other drugs… unluckly things are more dificult that in an isolated papper :(((

        1. Ofc Ergin, best wishes. Remenber we are here for similar reason and same Wish.
          About starvation i belive that in some way should work, not just about the nutrients that there are not , also for the hormones that body change level in that crisis time. Mature cells adapt to crisis time, unmature ca cells no.

          Kind regards.

          1. You are right Jandro,extreme changes in glucose levels can make changes in every part of the body.
            I remember while my mother was on IPT,her blood glucose was down to 30.She afraid too much because she saw yellow circles everywhere.And still sometimes she says she sees those circles.
            But phlorizin ,i dont know.as written in articles it has no correlation with insuline levels and you ll lower blood glucose slowly,and there ketones are working when glucose deprived up to an article.
            Thanks alot for entering this subject.We need more data.
            Kind Regards
            Ergin

  5. Dear friends, brothers and sisters.
    It’s been a year and 2 days since my mom had surgery, she is still alive, but she would hardly call it that way. Paralized still, our life changed for the worst.
    I’ve not forgotten any of you. i know i am not here much as i used to. Her needs require my continuous attention.
    It’s my birthday, so i hope you all grab a beer, and relax, maybe have a nicer weekend, take a moment to remind your loved ones how much they mean to you.
    Best of luck,
    Alex!

    1. Dear Alex

      Thank you for your words , they always make me feel better , even when I feel horrible

      from the bottom of my heart , I wish a happy long life for you and your dear mother , and I wish to see your life chane again for the best after your birthday

    2. Dear Alex,
      Happy birthday happy healthy years with your dear mom.
      Please search for oleuropein,this week i ll send you a bottle if you will use it ofcourse.
      Kind Regards
      Ergin

  6. Carl that is absolutely brilliant!

    When you can put in towards what everyone else is thinking you have a winner.
    It has become increasingly clear to me that such a patient initiated, treatment approach would be a great idea.

    Look at any cancer journal article and there will be detailed instructions of how to synthesize some cancer treatment
    that is quite likely to be much better and safer than the 50 year old chemo drug that your doctor is trying to prescribe to you.
    They might even be willing to prescribe something experimental that had at least some hint of clinical experience. However, when you read through the vast cancer literature you realize that very few of the ideas published ever make it to a patient.

    I had never thought it could be so easy to go DIY with a cancer vaccine. Most people would imagine that it must be so complicated, when perhaps it really is not. I will be very interested to see what other vaccines might be made. BRAF? Could then formulate it in a liposome or other carrier? It might create an immune storm though I would wonder about the Aldara, Monobenzone, CpG 1809 combo with a peptide vaccine (the first three were used in a mouse model of melanoma with impressive results).

    1. Indeed. I have been following Lars Haakon and his relentless work to save his wife for a while now. He is the kinda guy that doesn’t see failure as an option. This DIY-vaccine is one of the most impressive concepts I have seen, apart from what Daniel has achieved on this site. D.I.Y. science or “bio-hacking” is really a democratization of science and something we will just see more and more of when big-pharma fail to deliver. Read about another, very different, but really interesting fecal-matter-transplant experiment https://www.theverge.com/2016/5/4/11581994/fmt-fecal-matter-transplant-josiah-zayner-microbiome-ibs-c-diff

      Knowledge is power and determination can move mountains…

        1. I am following vaccine very close, i bealive is the correct way, cos in last 40 years there was not personalization ( like there was with bacterias) and cancer is a very very genuine/personal disease, all is result of self line mutation. Good some people have common points to be blocked, like pdl1, her2.. but most of them no. Thats a necesary step!! The issue i find now is that vaccine of peptides works when is showed in the surface, there is no way for something that is inside and ofc linfos will not atack.

          1. jandro,

            this one has intrigued me for some time:
            PMID: 20498710

            It seems so brilliant! There are quite a few people out there who want to be whiter.
            There are quite a few chemicals such as monobenzone that can help in depigmentation.
            The idea with the above treatment is that one could induce an autoimmune response against
            their melanocytes. This has certain dangers as other cells such as in the substantia nigra in the brain
            also have melanocytes, though the mice research reported a large response against melanoma.

            In terms of a preventative/therapeutic cancer vaccine one that I am familiar with is MUC1.
            This is along the lines of glycosylation/fucosylation that I posted about recently. This class of
            vaccine has been in the pipe for decades and decades and it still has not been approved. The entire FDA
            procedure of requiring single agent efficacy in a treatment setting makes no sense. If one of these vaccines
            were approved with only safety claims as a cancer preventative, I would be first in line to get it.

            I am not sure though if I would just send for the peptide sequence. Regulators should help give people
            better choices that are solidly backed by research.

            http://vxlbio.com/vaxils-lead-product-immucin-has-been-granted-an-orphan-drug-designation-by-the-fda-for-the-treatment-of-multiple-myeloma/

      1. Thanks Carl. I am in contact with Lars and very much like him. He is very well informed and I will study his DYI-vaccine approach asap. Thank you for sharing the info here as I did not had the time to do that yet. Kind regards, Daniel

        1. D, the above peptide sequence was published this year.

          It is the sequence to detach HK2 from the mitochondria. The last few proteins help the protein enter the cell. This could be even better than a vaccine. Detaching HK2 can have very powerful anti-cancer effects. The study found that normal cells were largely unaffected.

  7. Hi everyone !

    I am new to this page, just found it recently in my desperate search. Most websites I found actually were full of bombastic promises and trying to sell something.
    Long story short : I was feeling absolutely great all summer , but there was this lump in my breast. Late april on yearly mammography they told me there is a benign liph node, nothing to worry about. I trusted. But then in september I decided not to wait till the next yearly checkup and visited a doctor . Turns out I have a breast cancer ( 3 cm) + lymph-node metastasis. Triple negative and rather aggressive kind that reacts only to chemo.
    Had my first chemo yesterday.
    I am trying to find all complementary treatments that will help me get well and that I can afford ( I live on Hungarian income).
    I read so many contradictory information, not sure how to select
    I am taking or considering to take :
    Avemar (fermented wheat germ ) – not cheap stuff, but I read some good things – any of you have experience ?
    Artemisinin – I bought ” doctors best artemisinin” – is it ok ? any better source? Can it be taken with chemo ?
    Vitamon C – I was always taking large doses- can it be taken with chemo?
    D ( I have been taking 5000 IU for years) – should I continue with chemo ?
    MSM – 1 tablespoon – can I continue during Chemo ?
    wheat grass juice ( is it any good for this ? I am buying it frozen, not too cheap around here )
    Mustard seed, silver colloid, baking soda, etc etc
    Can you pls give me an overall opinion on how you would proceed , or suggest.
    In the fist step – I would like to make the chemo work and enhance all effects ( I was too scarred not to accept this )
    This situation is still so new to me and I am kin of lost – but in order not to lose my mind I need to treat this my healing as a project .
    Thanks for all inputs in advance
    Gabi

    1. hi Gabi,

      first of all regards from the shiny budapest. 🙂

      a few suggestions for your research:

      – when you research always try to check if there are studies showing results again your cancer type. Obviously there are metabolic similarities so many substances work against lots of cancer, however, in this regard i am not sure about Avemar for instance. It tends to help with side effects (vitalising) but it it is not proved to be useful against all types in the studies I have seen. Also not too cheap (of course its relative)

      – Probably your chemo is PRO-oxidant (resulting in higher ROS level in cancer cells leading to apoptosis). You should NOT take anti oxidants during your chemoterapy, like vit C. these are counteracting.

      – Try to exercise a lot even during chemo (well, maybe not on chemo days). Exercise increases your chance of survival for breast cancer. Exercise can be mild: Try to walk 60 minutes per day, or jog 15 minutes per day. I am amazed by the studies showing how much an active lifestyle can help with breast cancer (but not all cancers unfortunately). I can try to find the studies if you dont.

      – Chemo drugs are VERY different compared to each other. When in doubt, google for combinations like: “D vitamin * your cancer drug”. For instance, there are cancer drugs that are stronger with curcumin – but not each!! be aware of counter actions.

      – please research: EGCG, Curcumin, Melatonin, Metformin / Berberine, Chlorella, DCA, Doxycycline, ketogenic diet (or at least low carbohydrate like paleo), Mebendazole, Ala, HCA (also the metabloc protocoll inc ala plus hca), Qeurcetin, Rezveratrol, selenium, niacinamide (can make your chemo stronger), genistein, citric acid (i know, sounds weird).

      – VIT D is indeed useful, cheap and safe

      – dont care oo much about stats re triple negative, you are unique. Use chemo and use research to complement it.

      – there is a “how to make chemo stronger” article here, or something like this. Also “tips for treatment”. both very useful…

      all the best,
      W.

      1. Dear W

        Thanks for your answer. Not sure I understand all of it, but I am learning fast 🙂 .
        Regarding Avemar – I bought 2 boxes ( rather expensive stuff ) . I was given quite a lot of articles along with it- but of course they were selected by Avemar company- so not sure how much to trust. Do you think Avemar is anti-oxidant , actually pushing down the chemo effect ?
        Also , thanks for pointing out the importance of exercise . I have read a lot of articles . Really useful. Wasnt aware – the benefit percentages are impressive.
        Ketogenic diet : I was on keto diet since January this year ( with the only aim to lose weight, which I succeeded) and this developed in me while I was on keto. Now I switched to vegan keto , but its hard , due to a limited source of food ( not that i am too hungry since I learned I have cancer – very good appetite suppressant )
        Not sure if doctors here would be too cooperative in prescribing Metformine or other prescription drugs.
        Vit C : should I stop it only in the few days before/after chemo , or for the whole 5-6 months ( I will receive 6 chemos , every 3 weeks – 5FO, Epirubicin, Cyclofosfamid )
        Anyway, thanks for suggestions- and pls fill me with any information you might come up with if you have time
        Regards- Gabi

        1. hi Gabi,

          feel free to ask what you did not understand.

          Avemar – I am not aware of it being anti oxidant. I would take it as it helps with side effects too . Maybe you can ask the doctor, although its pretty sure he just will not care. are there avemar studies for your breast cancer type? (in lab or in animals)

          Ketogenic diet – Probably your “benign” lymph node was already cancerous in april, maybe I dont know breast cancer enough but I can ‘t see how you would develop a primary cancer and a metastasis in 6 months from a fully benign environment. This did not start when you were on keto, it started earlier. Although i see what you mean – you had a quick progression while on keto. I think vegan diet is also good – I would just avoid carbohydrates and move towards plant based. Its very hard i know. just like keto. Also, diet alone is not enough but a clever diet can increase your chance a little bit.

          – Read about dr longo and fasting ( short 1-2 days fasting before chemo seems to help for instance)

          – no, doctors will not prescribe you anything. Altough you can order Berberine from abroad, that is similar to metformin. And safe.

          – read about HCA + ALA , called metabloc (dont take this during chemo). safe and relatively cheap.

    2. Dear Gabi,

      Let us not forget the old and powerful Metformin, Aspirin, Diclofenac, Strategic fasting. They can help with your treatment, prevent metastasis or slow it down. Talk to your doctors. A “small” 3cm thing in the breast could probably be accessible trough skin and breast tissue, i’m talking about hyperthermia, lotions, radiation.
      This one is a personal “stupid” idea, like strangulation of the breast with ropes.
      Do talk to your doctors!

      Maybe look for nutritional lifestyle changes, also…. CUT DOWN spending$$$$, i hope that you will not need every single coin.
      Every disease like this needs something, try to use strategy to cut down it’s resources when it needs them most. Work with your doctors, do what you feel is best.
      Have a listen/look here https://www.youtube.com/watch?v=OjkzfeJz66o

      My best wishes and salutations to everyone.
      Alex

      1. Thanks Alex !

        The small thing could be accessible through skin- but doctors are treating me only with Chemo. In Hungary the situation in healthcare is not great . Doctors dont have long constructive conversations with you, and they will not really discuss too many options . You can mainly take the therapy – or not. I am too scarred not to.
        I cut down the carbs in January ( for weight loss reasons ) – and still got this thing develop in me from “benign lymph node” to 3 cm cancer + Lymphnode metastases from april to October . I am a little disappointed in nutritional option- but will continue ( no way I would go on carbs now ) 🙂
        If you come up with anything new, pls share

        Thanks in advance

        Gabi

        1. Gabi,

          I think Alex raised something important.

          Please check if hyperthermia is being used again your cancer type (I mean if there are human studies showing that it works) Some doctors here are not aware of this but they do this (for free) in hungary, although only regional / partial hyperthermia. You can arrange this.

          I think this (partial hyperthermia) is what you need as you dont have distant mets.

          In vienna they do full body hyperthermia for around 160 EUR per occasion.

    3. Gabi, how are we going to know if what you are taking is going to work with or against your current chemo, if you don’t tell us what chemo you received?
      For TNBC, there is a chemo that achieved 100% pathologic complete responses in a trial, but probably has serious side effects.
      A Phase I Study of Neoadjuvant Chemotherapy With Nab-Paclitaxel, Doxorubicin, and Cyclophosphamide in Patients With Stage II to III Breast Cancer.
      https://www.ncbi.nlm.nih.gov/pubmed/28579139

      1. Dear Ovidiu,

        I am getting : 5FO, Epirubicin, Ciclofaosfamid ( hope I spelled it ok )
        Thanks for sharing this study with me . Sounds promising.
        I will be grateful for any further advice too

        Regards,

        Gabi

        1. Dear Gabi,

          The FEC that you are taking now is typical for breast cancer, but a bit old and with response rates not great for TNBC of your stage.
          I suggest to get nab-paclitaxel (Abraxane) in your treatment if possible (paid by the health insurance?), because it increases response rates is TNBC.
          The main reason is, I believe, that nab-paclitaxel clears the cancer-associated fibroblasts, and possibly other tumor-associated cells. In TNBC, a rich tumoral stroma is associated with poor prognosis. Quoting from the paper referenced below:
          Interestingly, patients with TNBC harboring stroma-rich tumors (≥50% stroma) were found to have a poorer outcome than patients harboring tumors with small amounts of stroma. Opposite result was observed in ER positive breast cancers.
          Role of tumor microenvironment in triple-negative breast cancer and its prognostic significance.
          https://www.ncbi.nlm.nih.gov/pubmed/28729775

          It may be possible to reduce the cancer-associated fibroblasts with another drug, Pirfenidone (an anti-fibrotic).
          Targeting the cancer-associated fibroblasts as a treatment in triple-negative breast cancer.
          https://www.ncbi.nlm.nih.gov/pubmed/27756881

          I also found an article (inspired by the suggestion of hyperthermia by other posters) about a pathological complete response for a TNBC patient with a worse condition that yours, looks promising.
          Efficacy of Metabolically Supported Chemotherapy Combined with Ketogenic Diet, Hyperthermia, and Hyperbaric Oxygen Therapy for Stage IV Triple-Negative Breast Cancer.
          https://www.ncbi.nlm.nih.gov/pubmed/28924531

          I hope this helps, good luck!

  8. Gabi, I am so glad that you have found this site!
    It was such a great idea to trust your own intuition and not your doctor’s.

    There is an entire crew here that have been working away trying to understand cancer for the last few years.
    Cancer is much too much to try and cope with alone.
    As you likely know there is simply oceans of cancer research that no one by themselves can make any sense of.

    Just to give you an idea of something that I have found promising of late is positively charged nanoparticles. D, has a link on his news feed. Cancer cells will generally produce lactic acid, lactic acid has a negative charge, when the lactic acid leaves the cancer cell, it drags away positive charge from the surface of the cancer cell, making the surface of the cancer cell negatively charged. Non-cancerous cells do not have negative charges on their surfaces. So, this means that positively charged nanoparticles would selectively target cancer cells. Details of this are provided in the literature.

    I hope that we can help you.

    1. Thanks for giving me this information, I will definitely research – but the question is how to access these treatments ? They dont seem harmful , and I would love to hit this with all possible weapons that are not harmful.
      I will keep following the posts- but pls share with me anything you find ( especially on triple negative breast cancer )

      Thanks a lot in advance

      Gabi

      1. Gabi,

        after all of the years that I have been trying to find effective cancer treatments, I have finally arrived at the conclusion
        that connecting with the chemistry community would be of very great help. There are many many
        treatments that are described in the cancer literature that on the surface appear reasonably safe, yet probably will
        never make it to a patient. University researchers typically do not have 1 billion or more dollars to move it forward.
        So what happens is they publish very interesting ideas and then move onto the next interesting idea.

        My best suggestion would be to connect up with chemists or cancer clinics that could synthesize some of these impressive chemicals. You probably would not want to use it right away, though you would then have something for a rainy day. The idea is to do this now while time and health on your side.

        So often with cancer, people will let things drift forward possibly for many years and not have a well formulated strategy to fall back. It would be such a great idea if you took the opportunity now to formulate your back up plan. There are many many to choose from and many of them require very little chemistry.

        1. That’s a good idea.
          I may be coming down with something…. maybe… more stupid ideas … the kind only me can give lol.

          What do cancer cells produce that the rest of the body doesn’t? If we can identify such a chemical, we may possibly find another chemical that would create a “concrete” like substance in contact with that one produced by the tumor, thus blocking incoming nutrients, starving the tumor.

          Stupid crazy idea, i know….

          Alex

          1. Alex,

            there are so many of very impressive and apparently safe cancer treatments that I read about in almost every issue of every journal that I find. These great ideas are simply everywhere! Yet, typical cancer patients will go to their doctors and fill prescriptions for chemotherapy drugs, many of which have never shown any effectiveness at all for all of the decades that they have been marketed. The FDA has even admitted that many of these drugs would best be described as toxic placebos. Even placebo would be too strong a recommendation for these drugs because placebos can have beneficial effects that many cancer drugs never demonstrate.

            Metastatic patients then inevitably progress at which point mainstream medicine suggests people get their affairs in order. Even still your guidance to stay with traditional medicine is greatly appealing to many and for the great fraction of patients who have no other strategies is entirely reasonable. However, even for these patients it seems justifiable to suggest that at some point there will be no further help from mainstream medicine. At that point one would want to be able to access treatments that had not been more formally studied.

            As an example of such a treatment trajectory, consider the liver patient with 3-BP. After being given the only suitable drug which had a 2% response rate and an expected response time of perhaps a month or two, a response did occur. Yet, once this response faded there was no obvious go to treatment left. This did not stop the ethics panel from carefully considering the risks of 3-BP treatment even while the patient was in near terminal medical crisis. After 3-BP was finally administered the response to this treatment was almost immediate and the response continued to be evident as the treatment was continued over the next many months. At last labs there was no remaining detectable cancer. It is very difficult for me to understand why of all the millions of cancer patients who succumb to their illness each year more of them do not try some sort of an innovative approach when they have exhausted all of the options of modern medicine.

            One such option could be minicells. Minicells have shown a million fold increase in effectiveness over straight chemo.
            Clinical trials have been ongoing now for over ten years and they are still stuck in phase 1 development. They would not seem to be a rash or radical suggestion to those who might desperately needed something that could help them.

            1. I think many would go for 3-BP, or other treatments if they were to be actually applied, i for one can’t make this treatment available to my mother, even if i could, i wouldn’t know what i am doing, same goes for many other treatments and people in similar situations.
              These treatments need be administered by people who know what they are doing.
              If 3-BP is indeed so potent, i’m guessing a lot of people would be most interested to participate in a trial if they feel the have nothing to lose.

              What i was thinking before, regarding to your comment above, a fly trap, trojan horse, make it starve itself to death by either sealing its blood supply, thanks to blood additives that bind to chemicals secreted by the cancerous tumor or by adding to the blood some chemical that would immobilize the cancer cells, separate them from one another, chock them to death, some chemical that would stick to those cancer cells like a fly to honey.

              These ideas would likely create a lot of side effects, damage to surrounding tissues, inflamation, edema, necrosis,….
              But if they would work, they could hold the cancer at bay, granted we are talking about solid tumors.

              These ideas may have been worked on before, or are being worked on as we speak, however working on them would obviously require tons of money.
              I’m not talking about a cure, it’s more like an exploit. A “buy time” solution

              Cheers.
              Alex

              1. Alex, I know how difficult going off road would be for people.
                Staying with traditional medicine is likely the only choice for many people.
                Yet, at some point mainstream doctors simply say that they cannot help anymore.

                This has been the question that I have been especially interested in for all of these years.
                What are people expected to do then?
                It continues to surprise me that patients are then in the position that traditional medicine will not help
                and at the same time they can shut off any other options. I recently read this very situation where a patient was trapped into being in a state of limbo when traditional medicine would offer no treatments options while denying alternative approaches. I would feel so much better if traditional medicine had a greater latitude to help patients when conventional medicine no longer had much to offer. I do not understand why this is not the standard of care.It would be such a great step forward for patient care if this were true.

                As an example, PMID: 19709637.
                Tocotrienol has anti-cancer effects, though as this research finds simply giving oral doses will have no treatment effect. Yet, in mice iv dosing with nanoparticle tocotrienol had a significant anti cancer effect. This might not be a bad one to have on the shelf for a time when one ran out of other options.

                I would love if there were double blind placebo controlled phase 3 trials with this treatment to bring all the potential side effects and efficacy into the open. Yet, this research has been going on for almost a decade and no clinical trial is in sight. My best guess is there never will be a clinical trial. This approach is not the best of all possible worlds, though for many patients it might not be unreasonable.

                At the same time, I am becoming ever more cautious because I can see emerging pharma solutions that are very powerful. For example, minicells are moving through clinical trials. recently they announced that miRNA and siRNA minicells have been dosed in humans. If it is possible to begin selectively genetically reprogramming cancer cells with minicells, then very powerful anti-cancer treatments should now be on the horizon.

                Another idea that is exciting is the positive nanoparticles which is somewhat similar to your idea. A positive charge on a nanoparticle would selectively cling to the negative charge that exists almost exclusively on cancer cells. The payload could then be directed at the cancer cells.

                We have seen so many of those on our threads run out of treatment options. Perhaps having more options available ready for such occasions would be helpful.

  9. Gabi, don’t want to bother you but there is just so much exciting research out there that I want you to be aware of.

    Research did a simple combo of dox and vitamin C and it appeared to knock down cancer stem cells.
    PMID: 28978032

    From what I have seen, it is probably best to be open to ideas such as this.
    By itself low dose vitamin C likely would do little good and perhaps some bad, though when you add things together e.g. with the dox etc. there is some real potential.

    I have seen so many people on the 3-BP thread hum and haw endlessly even when they are in very
    serious condition and ultimately not take advantage of the many opportunities that are available to them.
    However, I would like to hear D’s opinion on this.

    Best Wishes.

  10. Alex, you are so correct that there are so many questions with this research.
    It would be of such great help to have one’s doctor to work through all the potential
    stumbling blocks. We might have to wait for more of a description of this in future work.

    I was wondering what would happen if higher doses of iv vitamin C could be combined with the dox.

    I looked again through the article for mention about sequencing this only after the tumor was no longer visible
    though I was not able to find this reference. It is possible that waiting for such a tumor response might be
    helpful, though from a first guess it also seems entirely possible that treating before such a disappearance
    would also be helpful: removing the cells that are driving the growth of the cancer could then allow you
    the chance to then simply remove the bulk of the non-CSCs. The big underlying question that you are likely
    referring to is how successful treatment targeting CSC would be if it might be surrounded by bulk cancer cells
    that possibly could shield them from the drugs. Unfortunately the article did not have an in vivo component to
    answer these questions.

  11. Alex, Ovidiu commented on this on the News thread on September 19th. He noted that dox can cause troubles including removal of helpful bacteria, inflammation –> and metastasis(?) that would need to be thought through carefully.

    1. My point was that doxycycline can’t be used for a long time, because of intestinal troubles. I have used doxycycline for my pets (treating flea borne diseases) in the past, and I can confirm those troubles.

      1. ovidiu, sorry for simplifying your comment, though I needed a reference to complexify the conversation.

        The research that I quoted of dox and vitamin c seemed so neat and tidy. Yet, as you noted there are a
        range of issues that would need to be considered for such a treatment. Even still the potential to directly
        attack the tumor growth driver is encouraging.

    2. Thank you jcancom.
      if i’m not mistaken, Ovidiu also mentioned suplimenting with Pro-biotics. My question would be, what strains would be suitable?! Variety has to be a bonus but what strains?!
      Best wishes,
      Alex

        1. Alex,

          it is very frustrating that with so many of the questions in alternative medicine the answers are so fragmentary.
          Even after 60 years of vitamin C, the answers are elusive.

          Clearly it is such an overwhelming advantage for pharma that they can spend the resources to find the answers that they need.

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