There are various very important aspects that emerge during our many discussions here, that are finally lost while I find them very valuable. As a result, I created this list in order to make sure we do not loose them. This is a list that will be alive and evolve:
- Using antiparasites/antibacterials prior to chemotherapy or other therapies
Some scientists across the world argue that tumors, specifically those of lungs but not only, may develop various bacteria/parazites that can lead to treatment resistance. Very recently, a breakthrough paper published in Science magazine is demonstrating exactly this fact: Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine http://science.sciencemag.org/content/357/6356/1156 (Thanks Jandro for pointing this out). In line with this research, I would always consider using antiparasites (example Ivermectin) and/or antibiotics (e.g. Doxycicline) prior to a major anti cancer treatment.
- Stop any (alternative or not) treatment that can put at sleep cancer cells prior to chemotherapy
It is well know that many of the chemo therapies are more effective in fast dividing cells. A recently published PhD thesis (Ref.) demonstrated that using drugs effective in slowing down tumor development (such as Metformin) may be good as it slows down cancer but is NOT suitable when those drugs are taken a few days prior to chemo, as they may make chemo less effective. Instead, the same work demonstrated that if Metformin is stop for a few days before chemo and is added starting with exactly the same day of chemo, the chemo effectiveness increases. I expect the same rule should apply to other therapies that have the potential to slow down cancers: i.e. stop that treatment 3-4 days prior to chemo, and start again the same day with chemo.
In contrast to the use of Metformin, here is why I actually think that fasting is actually good prior to chemo: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4901417/ and https://www.cancertreatmentsresearch.com/your-contribution-needed-on-breast-cancer-story-from-emad/#comment-6216
- Cimetidine is a great anti-metastasis off-label drug, but it may make some conventional treatments ineffective while for others it could enhance their bio-availability
Indeed, Cimetidine is often used at clinics across the world as an anti mets drug. I do strongly believe in its potential. We did used Cim for about 3 years and I believe it is a major reason why we succeeded to keep a very aggressive cancer confined for all these years to the initial locations where it was first detected. Here is more about Cim potential (Ref.) However, due to its impact on specific enzymes responsible for drug metabolization, Cimetidine may reduce or increase plasma level of specific substances. For example, some hormonal treatments used to treat breast cancer patients, in order to be effective they need to be metabolized first, which will not happen if Cimetidin (or e.g. grapefruit juice (Ref.)) is used. On the other hand, chemos or drugs that have low bio-availability could reach higher plasma level when Cimetidine (or graphruit juice) is used (Ref.). Therefore, prior to use Cimetidine patients should discuss with their medical doctor potential interactions with current medication. The interactions between drugs can also be checked here http://reference.medscape.com/drug-interactionchecker?src=google
- Inflammation is essential for cancer development and any effective anti cancer strategy should address this aspect with anti inflammatory drugs and/or supplements, specifically prior to a surgery
Here is a nice video shared sometime ago by Meech which I find extremely valuable and should be viewed by anyone considering a surgical intervention https://www.youtube.com/watch?v=H8zVrYEW8vE&feature=youtu.be
- When the patient is a child the dose needs to be lower
We often speak about drugs and supplements and related doses to be used. However, those doses are typically what needs to be used for adults. For non-adult patients of age 2-17, the dose has to be reduced according to Clark’s Rule which uses Weight in Lbs, NEVER in Kg. In order to convert kilograms (Kg) to pounds (Lbs), you need to know that 1Kg = 2.2Lbs.
Clark’s Rule says that Childs Dose = Adult Dose X (Weight in Lbs ÷ 150)(Ref.)
- Taking the treatment at the right time has important impact on both it’s effectiveness and toxicity: (Ref.) For example, Statins and Aspirin may have to be taken at night in order to have them doing their job (Ref.). A good review on how important is to take chemo at the right time is here (Ref.). This is a technical paper and a bit more difficult to read but extremely valuable as you may also find exact reference to the chemo we are interest in, and best way to take that. A more easy to read article, but at a higher abstraction level compared to the previous reference, is here (Ref.) and it was published very recently (April 2018) in Nature magazine.
- Alkalizing treatment may increase the effectiveness of some chemos, and may reduce that of other chemos. So take care! Indeed, it is known that some drugs are of acid type and others are of basic type. Like plus and minus. Acidic drugs are well absorbed in acidic environment while they will not get through when the environment is of basic type as they will react with the basic substances, and cannot not move further to do their job. This is why, when someone uses Bicarbonate for example, prior to chemo, that may strongly affect the effectiveness of chemo in a good or bad way depending on the type of chemo. This subject is discussed in more details somewhere at the middle of the following article https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/.
- Preventing invasive breast cancer with low dose oral Chloroquine given for 4 weeks prior to surgical excision of the lesions. The design of the trial can be found here, and the results of the trial can be found here. Based on the trial results, as well as private communication of one of the visitors of this website with the authors behind the trial, only one capsule of 250mg Chloroquine every week during 4 weeks, generates a measurable reduction in proliferation of the lesions and enhances immune cell migration into the duct. This approach is expected to be relevant for many epithelial cancers (the most common cancers).
- Anaesthetics and anaesthetic techniques used during surgical interventions influence tumor development. Here is a super useful document prepared by the Department of Anesthesiology, Intensive Care and Pain Medicine Netherlands Cancer Institute – Antoni van Leeuwenhoek Hospital Amsterdam (Compendium Anaesthesia in Surgical Oncology (version 1 3)). I am so happy to find such a high quality and forward looking work done by Dr. Michael Šrámek. This is a document you want to share with your surgery team so that they take the best decisions for you in terms of medication to use during the intervention.
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