Tips on Treatments: A List to be Constantly Updated

There are various very important aspects that emerge during our many discussions here, that are finally lost while I find them very valuable. As a result, I created this list in order to make sure we do not loose them. This is a list that will be alive and evolve:

 

 

  • Using antiparasites/antibacterials prior to chemotherapy or other therapies
    Some scientists across the world argue that tumors, specifically those of lungs but not only, may develop various bacteria/parazites that can lead to treatment resistance. Very recently, a breakthrough paper published in Science magazine is demonstrating exactly this fact: Potential role of intratumor bacteria in mediating tumor resistance to the chemotherapeutic drug gemcitabine http://science.sciencemag.org/content/357/6356/1156 (Thanks Jandro for pointing this out). In line with this research, I would always consider using antiparasites (example Ivermectin) and/or antibiotics (e.g. Doxycicline) prior to a major anti cancer treatment.
    .
  • Stop any (alternative or not) treatment that can put at sleep cancer cells prior to chemotherapy
    It is well know that many of the chemo therapies are more effective in fast dividing cells. A recently published PhD thesis (Ref.) demonstrated that using drugs effective in slowing down tumor development (such as Metformin) may be good as it slows down cancer but is NOT suitable when those drugs are taken a few days prior to chemo, as they may make chemo less effective. Instead, the same work demonstrated that if Metformin is stop for a few days before chemo and is added starting with exactly the same day of chemo,  the chemo effectiveness increases. I expect the same rule should apply to other therapies that have the potential to slow down cancers: i.e. stop that treatment 3-4 days prior to chemo, and start again the same day with chemo.
    In contrast to the use of Metformin, here is why I actually think that fasting is actually good prior to chemo: https://www.cancertreatmentsresearch.com/your-contribution-needed-on-breast-cancer-story-from-emad/#comment-6216
    .
  • Cimetidine is a great anti-metastasis off-label drug, but it may make some conventional treatments ineffective
    Indeed, Cimetidine is often used at clinics across the world as an anti mets drug. I do strongly believe in its potential. We did used Cim for about 3 years and I believe it is a major reason why we succeeded to keep a very aggressive cancer confined for all these years to the initial locations where it was first detected. Here is more about Cim potential (Ref.) However, due to its impact on specific enzymes responsible for drug metabolization, Cimetidine may reduce or increase plasma level of specific substances. For example, some hormonal treatments used to treat breast cancer patients, in order to be effective they need to be metabolized first, which will not happen if Cimetidin (or e.g. grapefruit juice) is used. Therefore, prior to use Cimetidine patients should discuss with their medical doctor potential interactions with current medication. The interactions between drugs can also be checked here http://reference.medscape.com/drug-interactionchecker?src=google
    .
  • Inflammation is essential for cancer development and any effective anti cancer strategy should address this aspect with anti inflammatory drugs and/or supplements, specifically prior to a surgery
    Here is a nice video shared sometime ago by Meech which I find extremely valuable and should be viewed by anyone considering a surgical intervention https://www.youtube.com/watch?v=H8zVrYEW8vE&feature=youtu.be
    .
  • When the patient is a child the dose needs to be lower
    We often speak about drugs and supplements and related doses to be used. However, those doses are typically what needs to be used for adults. For non-adult patients of age 2-17, the dose has to be reduced according to Clark’s Rule which uses Weight in Lbs, NEVER in Kg. In order to convert kilograms (Kg) to pounds (Lbs), you need to know that 1Kg = 2.2Lbs.
    Clark’s Rule says that Childs Dose = Adult Dose X (Weight in Lbs ÷ 150)(Ref.)

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

Please read an extended version of the Disclaimer here: https://www.cancertreatmentsresearch.com/?page_id=1794

Related Articles


Leave a Reply

146 Comments on "Tips on Treatments: A List to be Constantly Updated"

Notify of
avatar
Carl
Member

Excellent initiative Daniel! I have noticed your comments in the Forum regarding avoding Metformin before chemo. This is really interesting and I really would like to read the paper. I haven’t been able to find it myself so it would be great if anyone could provide a link

Meech
Member

One thing re: the talk that I posted on the forum.

While treating my tumours with ablation, Dr. Williams uses a slew of anti-vascular and anti growth factor drugs in the procedure. He also uses ketorolac, like Dr. Sukhatme recommended for surgery. So it may be of benefit for more than just surgery.

Wondering
Guest
ovidiu
Member
A warning on antibiotic usage: they don’t kill just the pathogenic bacteria, which may be responsible for chemo resistance, but also the probiotic bacteria. And probiotic bacteria may be quite useful, in combination with some chemo. Well-balanced commensal microbiota contributes to anti-cancer response in a lung cancer mouse model. https://www.ncbi.nlm.nih.gov/pubmed/26125762 So my advice is to avoid antibiotic use during chemo, besides the killing of useful bacteria, they may interfere with the cell cycle, and possibly antagonize chemo. I guess the optimal treatment would be antibiotics before chemo (stop at least 24h before), and then rebuild the microbiota with probiotics (some… Read more »
Emad
Member
Hi Daniel , I have to say something regarding the second point (on stopping any (alternative or not) treatment that can slow down cancer cells prior to chemotherapy) in the past I used to give a lot of DCA before 24 hours of chemo , and I felt like the chemo was always effective because of that , and for one time I stopped DCA for about 4 days of giving chemo , at that time the chemo didn’t have any effect , but also at that time I didn’t give DCA even after a week of the chemo I’m… Read more »
Alex
Member

Awesome article Daniel!
Thank you
Alex

Ergin
Member

Dear Daniel,
Very useful post,thanks alot.Especially about metformin.
May be it is a good chance for diabetic patients.Because they have to use a medicine everyday to lower blood glucose,
they can try phlorizin, dapagliflozin or canagliflozin in metformin-free days.

An article about fasting.
http://l-nutra.com/wp-content/uploads/2016/10/elsevier-march-2012.pdf
Kind Regards
Ergin

jandro
Member

You know Ergin, cana and dapa , block sugar intake in kidney, this could increase osmotic filtering increasing renal function and decreasing bioavility of other drugs… unluckly things are more dificult that in an isolated papper :(((

Ergin
Member

Just 1 day trial Jandro.Phlorizin deserves respect.Isnt it?

jandro
Member

Ofc Ergin, best wishes. Remenber we are here for similar reason and same Wish.
About starvation i belive that in some way should work, not just about the nutrients that there are not , also for the hormones that body change level in that crisis time. Mature cells adapt to crisis time, unmature ca cells no.

Kind regards.

Ergin
Member

You are right Jandro,extreme changes in glucose levels can make changes in every part of the body.
I remember while my mother was on IPT,her blood glucose was down to 30.She afraid too much because she saw yellow circles everywhere.And still sometimes she says she sees those circles.
But phlorizin ,i dont know.as written in articles it has no correlation with insuline levels and you ll lower blood glucose slowly,and there ketones are working when glucose deprived up to an article.
Thanks alot for entering this subject.We need more data.
Kind Regards
Ergin

Ergin
Member

BTW there are some reports:
After chronic oral usage of dapagliflozin,a ladies blood glucose lowered to 13 .

Alex
Member

Dear friends, brothers and sisters.
It’s been a year and 2 days since my mom had surgery, she is still alive, but she would hardly call it that way. Paralized still, our life changed for the worst.
I’ve not forgotten any of you. i know i am not here much as i used to. Her needs require my continuous attention.
It’s my birthday, so i hope you all grab a beer, and relax, maybe have a nicer weekend, take a moment to remind your loved ones how much they mean to you.
Best of luck,
Alex!

Emad
Member

Dear Alex

Thank you for your words , they always make me feel better , even when I feel horrible

from the bottom of my heart , I wish a happy long life for you and your dear mother , and I wish to see your life chane again for the best after your birthday

Ergin
Member

Dear Alex,
Happy birthday happy healthy years with your dear mom.
Please search for oleuropein,this week i ll send you a bottle if you will use it ofcourse.
Kind Regards
Ergin

Carl
Member

This is a really interesting approach to making a peptide vaccine yourself: https://docs.google.com/document/d/1Xk5S0DwdXy8bVY30PJA07Z_uWcXr5P6Ejt4cJj3pNBw/edit

It focuses on a lung-cancer mutation, but I guess it could be modified.

Found it on http://alunglife.com/goal-cure-cancer-method/

Jcancom
Member
Carl that is absolutely brilliant! When you can put in towards what everyone else is thinking you have a winner. It has become increasingly clear to me that such a patient initiated, treatment approach would be a great idea. Look at any cancer journal article and there will be detailed instructions of how to synthesize some cancer treatment that is quite likely to be much better and safer than the 50 year old chemo drug that your doctor is trying to prescribe to you. They might even be willing to prescribe something experimental that had at least some hint of… Read more »
Carl
Member

Indeed. I have been following Lars Haakon and his relentless work to save his wife for a while now. He is the kinda guy that doesn’t see failure as an option. This DIY-vaccine is one of the most impressive concepts I have seen, apart from what Daniel has achieved on this site. D.I.Y. science or “bio-hacking” is really a democratization of science and something we will just see more and more of when big-pharma fail to deliver. Read about another, very different, but really interesting fecal-matter-transplant experiment https://www.theverge.com/2016/5/4/11581994/fmt-fecal-matter-transplant-josiah-zayner-microbiome-ibs-c-diff

Knowledge is power and determination can move mountains…

Jcancom
Member

Carl, wow, maybe we have something here.

Could it really be as easy as ordering the peptide sequence —
MIASHLLAYFFTELNGKPILFF-amide?

jandro
Member

I am following vaccine very close, i bealive is the correct way, cos in last 40 years there was not personalization ( like there was with bacterias) and cancer is a very very genuine/personal disease, all is result of self line mutation. Good some people have common points to be blocked, like pdl1, her2.. but most of them no. Thats a necesary step!! The issue i find now is that vaccine of peptides works when is showed in the surface, there is no way for something that is inside and ofc linfos will not atack.

Jcancom
Member
jandro, this one has intrigued me for some time: PMID: 20498710 It seems so brilliant! There are quite a few people out there who want to be whiter. There are quite a few chemicals such as monobenzone that can help in depigmentation. The idea with the above treatment is that one could induce an autoimmune response against their melanocytes. This has certain dangers as other cells such as in the substantia nigra in the brain also have melanocytes, though the mice research reported a large response against melanoma. In terms of a preventative/therapeutic cancer vaccine one that I am familiar… Read more »
jandro
Member

Dear Jcancon: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5214696/
aldara was already used like adyuvant to vaccine in lung. Inmune stimulators i guess are going to grow up in this field.

Jcancom
Member

Faseb 31:5 pp. 2168-2188

Gabi
Member
Hi everyone ! I am new to this page, just found it recently in my desperate search. Most websites I found actually were full of bombastic promises and trying to sell something. Long story short : I was feeling absolutely great all summer , but there was this lump in my breast. Late april on yearly mammography they told me there is a benign liph node, nothing to worry about. I trusted. But then in september I decided not to wait till the next yearly checkup and visited a doctor . Turns out I have a breast cancer ( 3… Read more »
W.
Member
hi Gabi, first of all regards from the shiny budapest. 🙂 a few suggestions for your research: – when you research always try to check if there are studies showing results again your cancer type. Obviously there are metabolic similarities so many substances work against lots of cancer, however, in this regard i am not sure about Avemar for instance. It tends to help with side effects (vitalising) but it it is not proved to be useful against all types in the studies I have seen. Also not too cheap (of course its relative) – Probably your chemo is PRO-oxidant… Read more »
Gabi
Member
Dear W Thanks for your answer. Not sure I understand all of it, but I am learning fast 🙂 . Regarding Avemar – I bought 2 boxes ( rather expensive stuff ) . I was given quite a lot of articles along with it- but of course they were selected by Avemar company- so not sure how much to trust. Do you think Avemar is anti-oxidant , actually pushing down the chemo effect ? Also , thanks for pointing out the importance of exercise . I have read a lot of articles . Really useful. Wasnt aware – the benefit… Read more »
W.
Member
hi Gabi, feel free to ask what you did not understand. Avemar – I am not aware of it being anti oxidant. I would take it as it helps with side effects too . Maybe you can ask the doctor, although its pretty sure he just will not care. are there avemar studies for your breast cancer type? (in lab or in animals) Ketogenic diet – Probably your “benign” lymph node was already cancerous in april, maybe I dont know breast cancer enough but I can ‘t see how you would develop a primary cancer and a metastasis in 6… Read more »
Alex
Member
Dear Gabi, Let us not forget the old and powerful Metformin, Aspirin, Diclofenac, Strategic fasting. They can help with your treatment, prevent metastasis or slow it down. Talk to your doctors. A “small” 3cm thing in the breast could probably be accessible trough skin and breast tissue, i’m talking about hyperthermia, lotions, radiation. This one is a personal “stupid” idea, like strangulation of the breast with ropes. Do talk to your doctors! Maybe look for nutritional lifestyle changes, also…. CUT DOWN spending$$$$, i hope that you will not need every single coin. Every disease like this needs something, try to… Read more »
Gabi
Member
Thanks Alex ! The small thing could be accessible through skin- but doctors are treating me only with Chemo. In Hungary the situation in healthcare is not great . Doctors dont have long constructive conversations with you, and they will not really discuss too many options . You can mainly take the therapy – or not. I am too scarred not to. I cut down the carbs in January ( for weight loss reasons ) – and still got this thing develop in me from “benign lymph node” to 3 cm cancer + Lymphnode metastases from april to October .… Read more »
W.
Member

Gabi,

I think Alex raised something important.

Please check if hyperthermia is being used again your cancer type (I mean if there are human studies showing that it works) Some doctors here are not aware of this but they do this (for free) in hungary, although only regional / partial hyperthermia. You can arrange this.

I think this (partial hyperthermia) is what you need as you dont have distant mets.

In vienna they do full body hyperthermia for around 160 EUR per occasion.

ovidiu
Member

Gabi, how are we going to know if what you are taking is going to work with or against your current chemo, if you don’t tell us what chemo you received?
For TNBC, there is a chemo that achieved 100% pathologic complete responses in a trial, but probably has serious side effects.
A Phase I Study of Neoadjuvant Chemotherapy With Nab-Paclitaxel, Doxorubicin, and Cyclophosphamide in Patients With Stage II to III Breast Cancer.
https://www.ncbi.nlm.nih.gov/pubmed/28579139

Gabi
Member

Dear Ovidiu,

I am getting : 5FO, Epirubicin, Ciclofaosfamid ( hope I spelled it ok )
Thanks for sharing this study with me . Sounds promising.
I will be grateful for any further advice too

Regards,

Gabi

ovidiu
Member
Dear Gabi, The FEC that you are taking now is typical for breast cancer, but a bit old and with response rates not great for TNBC of your stage. I suggest to get nab-paclitaxel (Abraxane) in your treatment if possible (paid by the health insurance?), because it increases response rates is TNBC. The main reason is, I believe, that nab-paclitaxel clears the cancer-associated fibroblasts, and possibly other tumor-associated cells. In TNBC, a rich tumoral stroma is associated with poor prognosis. Quoting from the paper referenced below: Interestingly, patients with TNBC harboring stroma-rich tumors (≥50% stroma) were found to have a… Read more »
Jcancom
Member
Gabi, I am so glad that you have found this site! It was such a great idea to trust your own intuition and not your doctor’s. There is an entire crew here that have been working away trying to understand cancer for the last few years. Cancer is much too much to try and cope with alone. As you likely know there is simply oceans of cancer research that no one by themselves can make any sense of. Just to give you an idea of something that I have found promising of late is positively charged nanoparticles. D, has a… Read more »
Gabi
Member

Thanks for giving me this information, I will definitely research – but the question is how to access these treatments ? They dont seem harmful , and I would love to hit this with all possible weapons that are not harmful.
I will keep following the posts- but pls share with me anything you find ( especially on triple negative breast cancer )

Thanks a lot in advance

Gabi

Jcancom
Member
Gabi, after all of the years that I have been trying to find effective cancer treatments, I have finally arrived at the conclusion that connecting with the chemistry community would be of very great help. There are many many treatments that are described in the cancer literature that on the surface appear reasonably safe, yet probably will never make it to a patient. University researchers typically do not have 1 billion or more dollars to move it forward. So what happens is they publish very interesting ideas and then move onto the next interesting idea. My best suggestion would be… Read more »
Alex
Member

That’s a good idea.
I may be coming down with something…. maybe… more stupid ideas … the kind only me can give lol.

What do cancer cells produce that the rest of the body doesn’t? If we can identify such a chemical, we may possibly find another chemical that would create a “concrete” like substance in contact with that one produced by the tumor, thus blocking incoming nutrients, starving the tumor.

Stupid crazy idea, i know….

Alex

Jcancom
Member
Alex, there are so many of very impressive and apparently safe cancer treatments that I read about in almost every issue of every journal that I find. These great ideas are simply everywhere! Yet, typical cancer patients will go to their doctors and fill prescriptions for chemotherapy drugs, many of which have never shown any effectiveness at all for all of the decades that they have been marketed. The FDA has even admitted that many of these drugs would best be described as toxic placebos. Even placebo would be too strong a recommendation for these drugs because placebos can have… Read more »
Alex
Member
I think many would go for 3-BP, or other treatments if they were to be actually applied, i for one can’t make this treatment available to my mother, even if i could, i wouldn’t know what i am doing, same goes for many other treatments and people in similar situations. These treatments need be administered by people who know what they are doing. If 3-BP is indeed so potent, i’m guessing a lot of people would be most interested to participate in a trial if they feel the have nothing to lose. What i was thinking before, regarding to your… Read more »
Jcancom
Member
Alex, I know how difficult going off road would be for people. Staying with traditional medicine is likely the only choice for many people. Yet, at some point mainstream doctors simply say that they cannot help anymore. This has been the question that I have been especially interested in for all of these years. What are people expected to do then? It continues to surprise me that patients are then in the position that traditional medicine will not help and at the same time they can shut off any other options. I recently read this very situation where a patient… Read more »
Alex
Member

Dear J
I wonder what product containing these positively charged particles could be used relatively safe at a decent price.
Is there some chemical product?

Best wishes, have a nice weekend,
Alex

Jcancom
Member
Gabi, don’t want to bother you but there is just so much exciting research out there that I want you to be aware of. Research did a simple combo of dox and vitamin C and it appeared to knock down cancer stem cells. PMID: 28978032 From what I have seen, it is probably best to be open to ideas such as this. By itself low dose vitamin C likely would do little good and perhaps some bad, though when you add things together e.g. with the dox etc. there is some real potential. I have seen so many people on… Read more »
Alex
Member

That looks great for CSCs, that sounds like a strategy to be followed experimentally with doctor’s approval only AFTER no sign of tumor is seen, is this correct?

Cheers,
Alex

Jcancom
Member
Alex, you are so correct that there are so many questions with this research. It would be of such great help to have one’s doctor to work through all the potential stumbling blocks. We might have to wait for more of a description of this in future work. I was wondering what would happen if higher doses of iv vitamin C could be combined with the dox. I looked again through the article for mention about sequencing this only after the tumor was no longer visible though I was not able to find this reference. It is possible that waiting… Read more »
Jcancom
Member

Alex, Ovidiu commented on this on the News thread on September 19th. He noted that dox can cause troubles including removal of helpful bacteria, inflammation –> and metastasis(?) that would need to be thought through carefully.

ovidiu
Member

My point was that doxycycline can’t be used for a long time, because of intestinal troubles. I have used doxycycline for my pets (treating flea borne diseases) in the past, and I can confirm those troubles.

Jcancom
Member

ovidiu, sorry for simplifying your comment, though I needed a reference to complexify the conversation.

The research that I quoted of dox and vitamin c seemed so neat and tidy. Yet, as you noted there are a
range of issues that would need to be considered for such a treatment. Even still the potential to directly
attack the tumor growth driver is encouraging.

Alex
Member

Thank you jcancom.
if i’m not mistaken, Ovidiu also mentioned suplimenting with Pro-biotics. My question would be, what strains would be suitable?! Variety has to be a bonus but what strains?!
Best wishes,
Alex

ovidiu
Member

@Alex: free information on the matter is scarce, this the only one I found:
The Role of Probiotics in Cancer Treatment: Emphasis on their In Vivo and In Vitro Anti-metastatic Effects.
https://www.ncbi.nlm.nih.gov/pubmed/28890883

Jcancom
Member

Alex,

it is very frustrating that with so many of the questions in alternative medicine the answers are so fragmentary.
Even after 60 years of vitamin C, the answers are elusive.

Clearly it is such an overwhelming advantage for pharma that they can spend the resources to find the answers that they need.

Jcancom
Member

Alex, you asked about the microbiome.

It keeps popping up in the literature.
On the compass thread we commented on an article that found that
ipi responders had a modified gut flora. Below is another article that
found responders did better with a different microbiome. This is exciting
research as the article notes that changing microbiomes should not be
overly difficult.

https://www.sciencedaily.com/releases/2017/11/171102141827.htm

I also read of research that found that a type of cheese from Switzerland
was found to have a helpful probiotic. More details on this research will
be greatly anticipated

anca
Member
Dear Daniel and everyone here in need, I wanted to give an update of my mothers’s situation and tell about two pills, HYDRAZINE SULFATE and BASENTABS. It was like a rollercoaster to us. We stopped chemotherapy at the end of July, very weak and nothing was working the marker CA-125 was very big, 2 or 3000 and more, then we took 3 week sessions of high-dose vitamn C and Vitamin B17 (amigdalin) and Magnesium intravenous. My mother stomach is destroyed, maybe by chemotherapy, she has big pains in the stomach everyday. Vitamin C might have helped beuacause my mother’s CA-125… Read more »
W.
Member

Hi Anca and Daniel

Could it be that the decrease from 1700 to 1000 is a prolongued effect of Vitamin C IV? Mind you, you stopped in September and the new result came end of October. It is only somewhat more than one month.

I would be glad if it came from Hydrazine as it would be more sustainable but we cant be sure

Either way, it is amazing, Anca!

artwolf
Member

Any idea’s on alternative treatments or adjuncts to use for a friend of mine who was recently diagnosed with NHL Lymphoma.
They want to put him on the R-CHOP chemo protocol but he is looking for alternatives other than this routine to try an avoid the collateral damage that is inherent with Chemo. Thanks for your ideas and any help

Art

Jcancom
Member

artwolf, this is only 1 or 2 patients.
Not much to go on, though it is good to be aware of alternatives.

http://scientificmania.blogspot.ca/2013/04/non-hodgkins-lymphoma-case-studies-with.html

artwolf
Member

Thank you very much for the response Very interesting

Jcancom
Member
What is so frustrating about much of the cancer research is that there is no clear explanation for why these alternative treatments work for some patients. As was seen in the patients using DCA for NHL, DCA can be a very effective treatment is some patients. The problem is it is not known before the fact who those patients might be. This is true with so many treatments. For example, 3-BP etc. . Some 3-BP patients (likely quite selective) have had overwhelmingly massive responses, and others have not had any benefit. MCT-1 status probably would be a helpful biomarker. Patients… Read more »
artwolf
Member
What is so frustrating in my opinion is that on a conventional route we are still using the same game plan that was used decades ago that being CHEMO and or Radiation. Granted that some of the side effects might be able to be mitigated with the help of some newer drugs but the possible and probable collateral damage from Chemo still exist. After chemo fails initially or the Cancer builds a Resistance to it then you might be able to get on some of the newer pharmaceuticals but only after the chemo fails and damage has been done. I… Read more »
Jcancom
Member
artwolf, yes I certainly share this frustration. Metastatic cancer was cured in lab models 25 years ago. Since then it has probably been cured hundreds of different ways in mice and yet few if any of these approaches have translated into humans. Many of the thought leaders in cancer research have moved to other research questions that have not been as comprehensively studied as cancer. Is it really conceivable that none of the many approaches that successfully cured mice would not work in people? This seems very unlikely. The information above about Hydrazine Sulfate was a real eye opener. It… Read more »
Alex
Member
Hello everyone. Here to say that my mother’s markers have decreased considerably compared to when she got paralyzed and is now starting to feel her legs, still unable to move them at all, i’m thinking to get someone in fiziotherapy of kinetotherapy…. Before: LDH 386 \ CA 19-9 …66.85 \ CEA 67.53 –> 12-6-2017 Now: LDH 252 \ CA 19-9 …25.10 \ CEA 44.45 –> 1-11-2017 My mother’s analisis of the tumor reveals gene expression that can be addressed by ERLOTINIBUM/tarceva 150mg/day, so papers say from the doctors. She’s been taking this drug for 3 months now, going into her… Read more »
Ergin
Member

Hahahaaaaa
Alex this is the best news i have heard from months.I love her too much brother.
But please be brave and try more powerfull treatments,when the things are going good.
Call me i lost your phone.

Ergin
Member

May be people interest my knowledge and experiences just like Daniel and Pouya.
I saw that this the right place to write this.
Cancer patients passes away mostly because of embolism.
There are some tricks how you can understand this like albumin and others.
I saw this on lots of patients.
I can write it here or on another place.
Daniel should choose the right place.
Kind Regards
Ergin

Ergin
Member
We have to be more clever and more brave if we want do stg to beat cancer. We really need to take statistics. We need a statistics page which especially includes blood counts that we never tried.I ashamed to write all her blood counts here but i dont why now. We have to see the reality. Do not get into dreams while using DCA alone for example. I am following people who is writing against chemo. They are wrong unfortunately. Also in Daniels pages,every treatments which shows promise does not mean that it fits you.He already writes that it may… Read more »
Ergin
Member

And please do not forget this:
If you believe into evolution,
Cancer is a must…

Alex
Member
Thank you bro, honestly, i want to be careful with money. My mother needs too many things all the time. We can always use skype to talk, sadly i am not on computer very much because of my mother’s situation. After your mothers passing away, i can only say i am very very very very very very sorry, and i know it was not a good moment for conversation, i still don’t think it is. Maybe i am more sensitive, i dont know…. but after what you’ve been trough, i would take a serious vacation. Honestly i need one even… Read more »
ovidiu
Member

@Alex: good to know that your mother has the EGFR mutation (smokers usually have the Kras mutation) and TKIs can help her for some time.
As I mentioned some time ago, Erlotinib induces it’s own resistance by the activation of STAT3. However, Zoledronic acid can counter that.
Zoledronic acid increases the antitumor effect of gefitinib treatment for non-small cell lung cancer with EGFR mutations.
https://www.ncbi.nlm.nih.gov/pubmed/27109760
My advice is to search for options to increase the efficacy of Erlotinib and prepare alternatives for the time when it won’t be working anymore.

Alex
Member
@ Ovidiu SO if Zoledronic acid makes the cancer cells vulnerable to Erlotinib…. will that change? Is Zoledronic acid and erlotinib enough to get rid of it? Would cell death be higher than cell growth in that time? My mom get’s the acid every 21 days, she has pain for a few days after, then nothing much. What alternatives would there be? What more can actually be done? Not sure if radiation would work on the spine and cord, too much nerve involvment. As you well know, sadly, doctors don’t talk much. I would talk to the doctor/s if there’s… Read more »
ovidiu
Member
@Alex: after reading a couple of articles about the resistance to TKIs, I’ll try to summarize what I found out (maybe you already know this, but other readers don’t): – resistance to Erlotinib (other than resistance induced by EMT) develops about 10 – 14 months from the start of the treatment; – about 50% of the resistance cases is by the T790M mutation; the rest are by Her2 (EGFR is Her1), Kras or c-Met (HGFR) amplification, others possible; – the approved third generation TKI for the treatment of Erlotinib resistant (T790M) cancer is Osimertinib, which is probably extremely expensive… 🙁… Read more »
Alex
Member

i will say this as an initial reply.
The presence of your reply brought tears in my eyes.
Thank you for the time you take and most importantly, the heart you probably put into all this.
I will return with a more “full” reply

Alex

Alex
Member
@ Ovidiu Ok i’m back. I don’t know if Osimertinib could be obtained by us in Romania by goverment insurance. The price is an obvious killer. I think we’re very much closer to the problem my mom has than we were in the past. Better understanding of what’s going on. It seems like Disulfiram is the more budged focused one to buy. I took some vitamins and stuff, feels great! I hear they approved immunotherapy in Romania payed by goverment insurance, sadly not much more information on that has been given. She feels pain shortly after the Zoledronic acid, a… Read more »
ovidiu
Member
@Alex: before dealing with the T790M mutation resistance, you should try to deal with the resistance arising from EMT. While in bone tissue it may be partially reversed by Zoledronic acid, your mother probably has other metastases too. As mentioned before, Erlotinib makes cancer cells activate Stat3, but I found other articles that show also a YAP activation, as a survival response to Erlotinib. Combined treatment against EGFR, Stat3 and YAP yields the most killing of cancer cells. Both Stat3 and YAP high expression are associated with EMT and poor prognosis. As Stat3 inhibitors, besides Zoledronic acid (in bone tissue)… Read more »
Alex
Member

Thank you so much Ovidiu. I will study this reply in the coming days.
Meanwhile i hope you will have a nice and warm christmass
Best wishes, Alex!

Alex
Member

Artificial Inteligence and diagnosis of cancer https://youtu.be/0PGgCpXa-Fs they are saying it only costs 1$/scan

Zebra AI1

Could IBM Watson, also be of help to us here?

Pouya
Member

I just read an story on FB that a doctor managed to diagnose his own cancer using an ultrasound app. what interesting about this is that there may be a close day where everyone have cheap proper tools at home to check themselves on a regular basis hence a better chance of early diagnosis.

Pouya
Member

this is pouya btw. I wonder if D can help me replace my username to my own name.

Alex
Member

great to see you around pouya

Alex
Member
Dear Daniel Some people call everything they get via IV “chemotherapy”, and in fact that may be a good name. Not taking metformin prior to chemo sounds very smart, but it could perhaps be useful to specify some chemicals. It is the case that my mother is getting Zoledronic acid every 21 days and tarceva 150mg daily, for my mother and other good people who suffer from this horrible disease, may be more helpful to them if we have a higher degree of specificity and / or accuracy. If i am right, (and i may not be) Zoledronic acid, doesn’t… Read more »
Helga
Member

Dear Alex,

I apologise I haven’t responded to your latest note. It is great to hear that your mom is feeling better. I wish you and all of you a very happy and healthy new year, too!

Best,
Helga

W.
Member

hi guys,

https://medicalxpress.com/news/2017-11-decongestant-highly-effective-starving-cancer.html

NAC diminishing MCT4-levels – starving cancer.

NAC seems like a useful supplement – not to be used with 3-BP though…

EDIT: just seen that alternmed already linked this in another thread, decided to keep this here though 🙂

Aline
Member
Boa noite! Sou nova aqui porém acho muito interessante todas as informações, minha mãe tem câncer na bexiga com Metástase no pulmão, peritônio, e estômago porém ela sente dores fortíssimas na lombar e na barriga não consigo controlar essa dor com Lisador e dipirona, dei morfina pra ela porém é a única coisa que faz passar as dores só que por três vezes ela sentiu dores forte no peito e tive que parar com a morfina vocês pode me passar algum protocolo ou algo que eu possa fazer para melhor essas dores ? Google translation: Good evening! I’m new here… Read more »
Alex
Member

de mon expérience, vous pouvez essayer diclofénac ou aspirine + metformine avec de la nourriture 50 mg de diclofénac ou 500 mg d’aspirine + 500 mg de metformine pour 50 kg

Aline
Member
Obrigada, Alex vou tentar ela sente dores muito forte e nenhum analgésicos está fazendo mais efeito pra ela ainda não saiu a biópsia não sei o grau e qual o tipo de Câncer que ele tem, as coisas aqui no Brasil são bem difícil tudo demora ela fez a biópsia já faz 1 mês e ainda não saiu o resultado é as dores aumenta a cada dia, vou tentar obrigada mais uma vez 😉 Google translation: Thank you, Alex I’ll try she feels very strong pains and no painkillers are making more effect for her not yet left the biopsy… Read more »
W.
Member

Hi All,

Seemingly disulfiram has serious anti cancer properties and not just because of helping zinc uptake…

https://www.medicalnewstoday.com/articles/320281.php

W.
Member

Chemoterapy induced tumor debris (after apoptosis) makes the immunse system to release pro-inflammative cytokines

https://www.medicalnewstoday.com/articles/320227.php?iacp

this is a vicious circle leading to cancer recurrence even if the chemo was effective.

They are trying to stop this with the compound “resolvin” and studies so far are VERY promising.

Omega-3 contains this compound

siven01@yahoo.com
Member

And how can we find out what amount of omega 3 is needed? In the studies you are talking about, there is a need for a resolvine (6 μg / kg / day) to inhibit tumor growth.
The article discusses resolvines (e.g., RvE1, RvD1 and RvD2) and omega 3 contains RvD3. Is that equally beneficial?

siven01@yahoo.com
Member
Hello everybody . I have a new question. My wife (colon cancer surgery, liver metastases, splenic, lung …) is now making the second line chemotherapy with Irinotecan and Bevacizumabum. I’m still looking after a complementary treatment and thinking about the mistletoe. I found a forum on the following forum: “anyone with experience with this therapy. im starting this next month and heard it was realy good against chemo side effects, also helps the immune system and gives you a feel good exprience. im living in germany so the health insurance pays this , apart from the first blood test they… Read more »