Mebendazole: A Cancer Fighting Drug We Find at the Supermarket

Background:

Yes, in the European countries Mebendazole can be found on the supermarket shelves.

Mebendazole is an anthelmintic drug that has been used since the early 1970s to treat a range of parasitical worm infections, including threadworm, tapeworms, roundworms, and other nematode and trematode infections in humans and domestic animals (Ref.). The drug is among those on the World Health Organization’s list (WHO) (Ref.).

Mebendazole became and remained one of my preferred drugs since I learned about it at the beginning of 2014. This was mainly due to the multiple strong points that are defining Mebendazole. Those strong points are:

  • it has high potential for serious effectiveness against cancer supported by both
    • a large number of scientific publications (Ref.) and
    • clear case reports in humans, where, Mebendazole alone was effective in inducing cancer regression, in cancer patients with adrenal cancer (Ref.) and colorectal cancer (Ref.), not responding anymore to conventional treatment methods
  • it has nearly no side effects, and due to this reason
  • it is an over the counter drug in most of the countries, which means there is no need for a doctor prescription
  • and on top of all, it is a very cheap drug
  • available virtually anywhere and everywhere.

The first website where I came across Mebendazole discussion was, I think, this one: http://www.abovetopsecret.com/forum/thread822776/pg1 I was happy to see in 2014, just a few months latter after I studied Mebendazole intensively and became convinced about its anti cancer relevance, a paper has come out from one of my favorite Anti Cancer Foundation, i.e. Anticancer Fund, consolidating a good amount of research and proposing Mebendazole as a re-purposed drug against cancer. Here is that nice paper published in 2014: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/ By that time, we were already using it.

Before and after the publication of the above paper by Anticancer Fund, there were multiple relevant scientific papers published around Mebendazole and multiple discussions, triggering me to start writing about Mebendazole. Interestingly and amazingly, in 2016, a drug company has decided to charge 200x higher price for Mebendazole (thanks to Helga, a reader of this website I learned about this) (Ref.). Fortunately, it seems that in the US there is still available a powder form that is cheap. Alternatively, it can anyway be ordered online as discussed below in the “Source” section. This was another point when I wanted to write about Mebendazole. Today, finally, I succeeded to write this post, triggered again by another publication coming from US Oncology center and School of Medicine, suggesting the re-purposing of Mebendazole as a replacement for Vincristine chemotherapy for the treatment of Brain tumors (Ref.).

Credit photo: https://valelab.ucsf.edu/research/microtubules/

While many of the constant readers of this website already know Mebendazole, I hope the article will help the awareness of new readers.

Indeed, Mebendazole, alone or combined with chemo, has been shown to be effective against multiple forms of cancer cells, such as:

  • adrenal cancer (Ref.1, Ref.2)
  • colon cancer (Ref.1, Ref.2)
  • brain cancer, medulloblastoma, glioblastoma (Ref.1, Ref.2, Ref.3, Ref.4)
  • melanoma (Ref.1, Ref.2, Ref.3)
  • head and neck squamous cell carcinoma (HNSCC) (Ref.)
  • cholangiocarcinoma or bile duct cancer (Ref.)
  • gastric cancer (Ref.)
  • breast cancer (Ref.)
  • lung cancer (Ref.1, Ref.2)
  • ovarian (Ref.)
  • leukemia (Ref.)
  • pancreatic cancer (Ref.)

A study, showed a high level of activity against leukaemia, colon cancer, CNS and melanoma cell lines, with lesser activity in breast, ovarian, renal and NSCLC lines (Ref.).

Based on all the research available, I would expected the highest chance of effectiveness of Mebendazole, against

  • adrenal cancer,
  • colon and colo-rectal cancer,
  • brain cancer,
  • melanoma and
  • leukemia

and possibly

  • pancreatic cancer and
  • lung cancer

However, given the low cost, limited to now side effects, its availability and potential, I would still try it for the other cancer types (next to other treatments), specifically for the aggressive cancer types. Based on the above results, the other potentially responsive tumor types seem to be those of

  • ovarian,
  • breast,
  • bile duct,
  • gastric.

Note: other anthelmintic drugs have also been shown to present strong anti cancer effects, but their main anti cancer mechanisms may be different. Of the anthelmintic category, Albendazole is one of my other favorites due to its unique anti cancer mechanism (to be discussed elsewhere) but that comes with some liver toxicity. Albendazole has been indicated to be effective against, e.g. ovarian cancer (Ref.). Here is a study suggesting that of the existing repurposed drugs, antiparazite medication is one of the most effective group of drugs against cancer, after typical anti neoplastic drugs (Ref.).

The ever growing evidence that anti parasitic medication is effective against cancers may also trigger medical doctors and researchers look at cancer from other perspectives, e.g. cancer as a parasitic disease, a perspective which so far has been only discussed outside the mainstream medicine. Here is an example that consolidated such a perspective http://jeffreydachmd.com/2016/05/cancer-as-a-parasitic-disease/ I think, successful researchers have to always keep their mind open, ready to consider new perspectives proposed by others and even better connect the available “dots” to generate new perspectives.

As we will discuss further, the only drawback with Mebendazole is that due to its absorption which can be different in different patients, the results may vary from patient to patient.

According to recent research, Mebendazole may inhibit Multi Drug Resistence (MDR) transporters (Ref.). These are the transporters used by cancer cells to push out chemotherapies in order to survive during chemo treatments. Therefore, using Mebendazole during chemo treatments may lead to increase effectiveness of the conventional therapies.

Case Reports in Humans:

Besides all the studies in the lab indicating the effectiveness of Mebendazole against various cancer types, below are two published scientific case reports that are clear and coming from trust-able sources. In both cases, Mebendazole has been applied after the patients were not responding anymore to conventional therapies. The medical doctors have decided to use Mebendazole following scientific results from various research groups suggesting Mebendazole may be effective for those cancer types. This indeed, was the case. The results were extremely promising:

Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma https://www.ncbi.nlm.nih.gov/pubmed/21454232
Here is a PDF version available.

A 48-year-old man with adrenocortical carcinoma had disease progression with systemic therapies including mitotane, 5-fluorouracil, streptozotocin, bevacizumab, and external beam radiation therapy. Treatment with all chemotherapeutic drugs was ceased, and he was prescribed mebendazole, 100 mg twice daily, as a single agent. His metastases initially regressed and subsequently remained stable. While receiving mebendazole as a sole treatment for 19 months, his disease remained stable. He did not experience any clinically significant adverse effects, and his quality of life was satisfactory. His disease subsequently progressed after 24 months of mebendazole monotherapy.

My comments: as discussed in the article, the patient received only 200mg Mebendazole each day. That to me is the lowest daily dose and according to multiple sources the dose could be further increased with no issues. In addition, Mebendazole is known to be poorly absorbed in the body and there are ways to increase its absorption. All these will be further discussed in the “Dose and Application” section below, but the point is that while the medical doctors authors of this article have my highest regards, in the future higher dose can be used to try increase Mebendazole effectiveness.

Drug repositioning from bench to bedside: tumour remission by the antihelmintic drug mebendazole in refractory metastatic colon cancer. https://www.ncbi.nlm.nih.gov/pubmed/24160353
Here is a PDF version available.

A patient with refractory metastatic colon cancer was treated with MBZ at the standard anthelmintic dose of 100 mg twice daily. The patient experienced no subjective adverse effects at all from the drug and computerized tomography evaluation after six weeks of therapy showed near complete remission of the metastases in the lungs and lymph nodes and a good partial remission in the liver. At this stage, the liver enzymes AST and ALT were found elevated up to five and seven times above upper limit of normal and mebendazole was temporarily stopped and then reintroduced at half dose. Liver enzymes slowly decreased and the patient still reported no adverse effects from mebendazole. The disease was stable at a new CT, confirming the response observed earlier.

My comments: Since Mebendazole is not associated with hepatic dysfunction (Ref.) and since the daily dose used here is on the very low side, I suspect the elevation of AST and ALT was due to the tumor lysis.

Mechanism:

The primary anti cancer mechanism is related to the depolymerization of tubulin in human tumor cells caused by Mebendazole, inhibiting mitotic spindle formation, and therefore inducing mitotic arrest and apoptosis. This is a mechanism similar to that one I already described in details in the post on Griseofulvin: http://www.cancertreatmentsresearch.com/decide/ so I will not discuss again, here, the details of the mechanism.

Indeed, Mebendazole has been shown to cause mitotic arrest in parasitic cells as early as 197o’s (e.g. Ref.). As a reference for the reader, at some level, Mebendazole acts similar to microtubule dynamic inhibiting chemotheraphies such as microtubule-stabilizing (e.g., paclitaxel, docetaxel) or microtubule-destabilizing (e.g., vinblastine, vincristine, nocodazole, colchicine) agents (Ref.)

Mebendazole has been found to work against tumors via other mechanisms as well:

  • angiogenesis inhibition (Ref.) MBZ may inhibit the action of VEGFR-2 by binding to it (Ref.)
  • inactivates Bcl-2 and activates caspases to promote apoptosis in cancer cells, and the release of cytochrome c, which has also been shown to trigger apoptosis in malignant cells (Ref.). Here is how Bcl-2 fits into the picture (Ref.).
  • hedgehog inhibitor (Hh) (Ref.) Here is how hedgehog fits into the picture (Ref.). The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents. Hedgehog ligands or markers of downstream pathway activity have been detected in melanomas, lung cancers, ovarian cancers, adrenocortical cancers and colorectal cancers (Ref.), which are all responsive to Mebendazole, as discussed above. Interestingly, among other Hedgehog inhibitors that have previously identified are also drugs that interact with microtubules, including vinblastine, vincristine, and paclitaxel (Ref.). Itraconazole, that I previously discussed in a different post is also a hedgehog inhibitor: http://www.cancertreatmentsresearch.com/itraconazole/ So there may be a connection between hedgehog inhibition and microtubule dynamics inhibition.
  • based on the fact that ultra low dose microtubule inhibiting chemotherapy is known to activate the immune system, (http://www.cancertreatmentsresearch.com/ultra-low-dose-taxol/) it has been proposed that Mebendazole could do the same (Ref.)

Interestingly, Mebendazole is not toxic against normal cells. Researchers speculated a defect in at least one mitotic checkpoint function in tumor cells leading to their higher sensitivity to Mebendazole (Ref.).

Side effects:

In general, the drug is well tolerated but some people may present adverse effects and may have to discontinue. Here is the product description https://www.janssen.com/canada/sites/www_janssen_com_canada/files/product/pdf/ver11192014cpm.pdf

At high dose, it has been found to possibly induce bone marrow suppression in patients chronic liver disease (Ref.) That reverted to normal after the drug was stopped. There are rare reports of reversible alopecia, urticaria, rash, gastro-intestinal upset, leukopenia, and neutropenia in some patients treated with high-dose MBZ (Ref.)

MBZ is contraindicated during pregnancy, due to its potential anti-angiogenesis properties.

In the event of accidental overdose, abdominal cramps, nausea, vomiting and diarrhea may occur (Ref.).

Dose and Administration:

One of the challenge with Mebendazole administrations is its low bioavailability which leads to only 20% absorption. The mebendazole plasma concentration-time profiles differed considerably between patients receiving 10 mg/kg Mebendazole; elimination half-lives ranged from 2.8-9.0 h, time to peak plasma concentration after dosing ranged from 1.5-7.25 h and peak plasma concentrations ranged from 17.5 to 500 ng/ml. (Ref.) Such doses are indeed in the plasma level reported to achieve anti cancer effects in the lab. Hoewever, as it can be seen the distribution of plasma level is wide so not everyone will reach high plasma level of Mebendazole.

Therefore, to address the challenge related to reaching a high level of mebendazole plasma level, which on one hand is due to the bad absorption and on the other hand due to a strong first pass metabolism in the liver, the following actions can be taken:

  • administer with a fatty meal (Ref.)
  • long term administration (Ref.)
  • increased dose may increase the absorption (Ref.)
  • given with Cimetidine (another of my preferred anti cancer drugs) (Ref.) will reduce its metabolism in the liver. Cimetidine can be found as an over the counter drug on eBay but should be used with care when combined with chemo as it will increase the plasma level of some of the chemos.

The low bioavailability is also probably why its side effects are very limited. Mebendazole is rapidly metabolized to less toxic metabolites by the liver, and this could be another reason for its low toxicity (Ref.). Increasing the plasma level with the strategy mentioned above, may also bring some side effects, so have an eye on that.

According to the literature, some people may absorb better Mebendazole compared to other, that may also lead to different effectiveness of Mebendazole in different people.

In the two successful case reports referenced above, the patients have used the minimum dose typically used against worms, i.e. 100mg 2x/day.

This, to my opinion is on the low side of the dose but could be the starting dose. A high dose, but still feasible, according to a World Health Organisation reference (Ref.) cited by the Anticancer Fund (Ref.), could be up to of 40–50 mg/kg/day for at least 3–6 months. This seems to be the long-term treatment of cystic echinococcosis. Another reference in terms of max dose still feasible is that used for alveolar echinococcosis, where 40–50 mg/kg/day is used with treatment for at least two years, and possibly longer for patients with inoperable disease (Ref.).

Based on the above, a person of 50kg could use up to 2.5g Mebendazole for months to years. Actually, this website pointed out a discussion on Inspire website where a caregiver said a brain cancer patient accessing a clinical trial at John Hopkins Hospital was “taking 2500mg in the morning, 3000 mg in the afternoon & evening.” (Ref.) That is really a huge dose.

Indeed, there was a clinical trial at John Hopkins Hospital, involving Mebendazole for Brain cancer gave it at 3x500mg/day with meals, on a 28 day cycle (Ref.). I haven’t found yet the results reported.

Following the above discussions, I would take the daily dose split into two, during or just after breakfast and dinner, if possible together with Cimetidine 400mg 2x/day. I would always start with a low dose Mebendazole and go up step by step to the target dose. If the target dose is very high, I would split that in 3x/day. Also, please note that in the clinical trail they did not used Cimetidine. And since Cimetidine may very much increase the plasma level of Mebendazole (some say by 50%), in case we use that I would make sure the target dose is lower than what was used at John Hopkins Hospital.

Janssen Pharma product descriptions states the following regarding the dose: “In controlled safety studies, humans have received from 100 to 1200 mg of mebendazole daily for up to 14 days with no reported side effects.” (Ref.)

Source:

The brand name is Vermox, Benda, etc. sold as a solution or tablet. I prefer the tablet version. Those tablets come in 100mg or 500mg version. I prefer the 500mg version and cut them in pieces if lower dose is required.

Mebendazole is available at many pharmacies in many countries, online and over the counter. Here is an example of a version that is available over the counter at a super market in the Netherlands: https://www.kruidvat.nl/kruidvat-anti-worm-mebendazol-100mg-tabletten/p/1023933 . In this case 6x100mg tablets costs 3 euro.

Another option is to buy from eBay or from sites like this one: http://smartproduct4u.com/?ref=285 many of which are coming from Thailand.

Finally, if there is no other option or would like to go the low cost version, we can buy it from China, via Alibaba, at a cost of about 200 euro/kg if I remember correctly. But that is powder version. Btw, just think about this: 200 euro for 1000g in China vs. about 800.000 euro for 1000g in USA, after the price increase initiated by a US drug company last year. Imagine the gross profit on this one. How can, we, the society accept something like this???

Other clinics recommending Mebendazole:

Care Oncology Clinic in London, UK: http://careoncologyclinic.com/ They usually seem to give to their patients a combination of drugs including Sratin + Metformin + Doxycycline + Mebendazole. Here is an article explaining in details the price, activity and vision of this clinic http://www.telegraph.co.uk/wellbeing/health-advice/crowdfunding-cure-cancer/

References:

Mebendazole monotherapy and long-term disease control in metastatic adrenocortical carcinoma https://www.ncbi.nlm.nih.gov/pubmed/21454232

Repurposing Drugs in Oncology (ReDO)—mebendazole as an anti-cancer agent https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/

Mebendazole, a well-known anti-helminthic drug in wide clinical use, has anti-cancer properties that have been elucidated in a broad range of pre-clinical studies across a number of different cancer types. Significantly, there are also two case reports of anti-cancer activity in humans. The data are summarised and discussed in relation to suggested mechanisms of action. Based on the evidence presented, it is proposed that mebendazole would synergise with a range of other drugs, including existing chemotherapeutics, and that further exploration of the potential of mebendazole as an anti-cancer therapeutic is warranted. A number of possible combinations with other drugs are discussed in the Appendix.

Repositioning of the anthelmintic drug mebendazole for the treatment for colon cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3825534/

Sixty-eight compounds were defined as hits with activity in both of these cell lines (<40 % cell survival compared with control) at 10 μM drug concentration. Analysis of chemical similarity of the hit compounds revealed several distinct clusters, among them the antiparasitic benzimidazole group. Two of these compounds, mebendazole (MBZ) and albendazole (ABZ) are registered for human use. Data from the NCI 60 cell line panel revealed only modest correlation between MBZ and ABZ, indicating differences in mechanism of action. This was further supported when gene expression signatures were compared in the CMAP database; ABZ ranked very low when MBZ was used as the query signature. Furthermore, MBZ, but not ABZ, was found to significantly interact with several protein kinases including BCR–ABL and BRAF. Analysis of the diagnosis-specific activity of MBZ showed activity in 80 % of the colon cancer cell lines in the NCI 60 panel. Three additional colon cancer cell lines and three cell models with non-malignant phenotypes were subsequently tested, confirming selective colon cancer activity of MBZ. MBZ seemingly has repositioning potential for colorectal cancer therapy.

Repurposing the antihelmintic mebendazole as a hedgehog inhibitor https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4297232/

The hedgehog (Hh) signaling pathway is activated in many types of cancer and therefore presents an attractive target for new anticancer agents. Here we show that mebendazole (MBZ), a benzamidazole with a long history of safe use against nematode infestations and hydatid disease, potently inhibited Hh signaling and slowed the growth of Hh-driven human medulloblastoma cells at clinically attainable concentrations. As an antiparasitic, MBZ avidly binds nematode tubulin and causes inhibition of intestinal microtubule synthesis. In human cells, MBZ suppressed the formation of the primary cilium, a microtubule-based organelle that functions as a signaling hub for Hh pathway activation. The inhibition of Hh signaling by MBZ was unaffected by mutants in the gene that encodes the Hh pathway signaling protein SMO, which are selectively propagated in cell clones that survive treatment with the Hh inhibitor vismodegib. Combination of vismodegib and MBZ resulted in additive Hh signaling inhibition. Because MBZ can be safely administered to adults and children at high doses over extended time periods, we propose that MBZ could be rapidly repurposed and clinically tested as a prospective therapeutic agent for many tumors that are dependent on Hh signaling.

Combination of Manumycin A and Mebendazole in Human Breast Cancer Cell Lines, a PhD thesis from 2010 https://uh-ir.tdl.org/uh-ir/bitstream/handle/10657/166/HADDADIN-.pdf?sequence=2

An article on Mebendazole, on a nice website of a breast cancer patient: https://magiccocktailquest.wordpress.com/2015/06/08/mebendazole/

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

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37 thoughts on “Mebendazole: A Cancer Fighting Drug We Find at the Supermarket

  1. Thank you Dear Daniel for all the priceless articles and information but also support you’ve so generously dispensed to us and the public.
    May you have all the good health in the world to help you achieve your goals in life.
    Warm Regards,
    Alex

    1. Thank you Alex!
      However, instead of keeping for myself, I would like to pass all that to your mom and all those who are in very much need for good health. I hope this type of information will help on that line as well.
      Also, you were ultrafast with posting a comment here, as I just published the post 🙂

      Kind regards,
      Daniel

      1. Dear Daniel,
        With regard to speed i write to you.
        The link to the table https://1drv.ms/x/s!AgyLnvi3scoTojUrZihYZ4-NM1Ke
        Between 18-feb and 6-march we only used aspirin and cbd oil
        The rest is familiar, ALA, HCA, DCA, CA, Resveratrol, Cabbage Brine, Silimarin, etc…………..
        Funny thing is when we used only those 2, we got apparently slower growth than we are getting now.
        I remember one of Ergin’s reply about HCA potentially boosting cancer, i wonder and ponder.
        Are you pondering what i am pondering?
        It may prove crucial for so many to determine if HCA is to be “blamed” since in theory, all the others would have blasted cancer hard, in theory, at least hold it in place and not allowing it to grow.
        So here i am a bit more “focused”.
        Many many Thanks,
        Alex

        1. Dear Alex,

          So far, all the science I came across indicates the anti cancer potential of HCA and not the other way around. As a result, I do not resonate with your thoughts. If you find literature to support that I would be please to closely study that. You could start your research by using this keywords in Google search “hydroxycitrate cancer growth”.
          It is easy for us to make misleading connections. To makes sure we made the right connections, we should constantly zoom in and zoom out.
          Regarding your observation, i.e. tumor markers were growing slower at beginning compared to now could be due to at least 3 major reasons:
          – it is well known that tumors have an exponential growth – so it is possible that nothing of what you did actually seriously affected the normal trend of the tumor growth
          – it is possible that while using high dose Aspirin you succeeded to dampen the tumor growth more than you did latter when you lowered the dose. However, that treatment was not sustainable since if you would continue with the oral dose you used at beginning you could also kill you dear mom not only the tumor due to the side effects that come with long term use of very high dose Aspirin.
          – it could also be that CA fueled the tumor growth
          Time will tell which of the above is true.
          In conclusion, there is no way in my mind to connect HCA with tumor growth.

          I would also like to kindly ask you and all, if we could address the questions in the right post so that when we look back for something we can find it in the right place. Thus, HCA question could be addressed in the anti cholesterol strategy post or the post on ACLY inhibition.
          Thanks in advance for considering this aspect in the future.

          Kind regards,
          Daniel

    1. I do know someone using for long time Albendazole but he was using a lot of supportive supplements for the liver as well.

      In a clinical trial, Albendazole was given orally on a day 1–14 of a 3 weekly cycle, starting at 400 mg BD with dose escalation until 1,200 mg BD.

      Result of the trial: The maximum tolerated dose was 2,400 mg per day (1,200 BD). Myelosuppression was the main dose limiting toxicity. Fatigue and mild gastrointestinal upset were the other major adverse effects. 4 out of 24 assessable patients (16%) had a tumor marker response with a fall of at least 50% from baseline values and another patient had a prolonged period of stable marker response. A decline in plasma vascular endothelial growth factor levels was observed.

      Conclusions of the trial: Albendazole was well tolerated on the schedule tested in this trial. The results of this study suggest that the recommended dose for further study is 1,200 mg twice daily for 14 days in a 21-day cycle.

      Supporting the liver: e.g. silymarin, hepamertz, astragalus, alpha lipoic acid

  2. I always get excited when i receive a notification saying you posted a new article. Thanks again for an excellent summary! It might be interesting to know that the Care Oncology Clinic cycles MBZ with Doxycycline. One month on, one month off
    Regards,
    Carl

  3. Dear Daniel,
    Thank you for this new post.I like mebendazole too much.
    It is in my top 3 drug list.I have seen good responces after taking mebendazole.
    As far as i know,alternmed was using Albendazole for his dear mom.
    Kind Regards
    Ergin

      1. Hi Daniel,
        1-Why mebendazole?Bowel obstruction released,it is a perfect happening for us these days.
        2-Phlorizin,as you know i am in love with it and i will use it as a golden shot with hyperthermia.
        3-Lonidamine.(It is working synergetic with Phlorizin)
        There is a comparison with 3BP and Lonidamine below but i dont understand too much.Which one is better?
        https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4585687/
        Kind Regards
        Ergin

  4. Both the Kruidvat drug store chain as its twin compagny Trekpleister sell them at 2.59 euro (2.75 USD today) OTC in the Netherlands (I am Dutch). However they appear not to sell them online abroad. They are selling a generic copy of the originals, but besides color of the tablet, I havent noticed any difference (have used both in the past).

  5. As far as the Norwegian CRC patient with great initial response…in the end brain mets turned up. His doctor tried the MBZ approach in five other patients, with only one minor response as result.

    1. Indeed, there is a paragraph on that in the Anticance Fund article stating the following:
      “A case of metastatic colon cancer treated with MBZ was described by Peter Nygren and Rolf Larsson in 2013 [24]. Here, a 74-year-old patient suffering from progressive metastatic colon cancer had been treated first with capecitabine, oxaliplatin, and bevacizumab, and then by capecitabine and irinotecan in the face of disease progression, and who had no standard treatment options available was started on an oral dose of MBZ of 100 mg twice a day. MBZ was selected based on the author’s previous pre-clinical work with MBZ [20]. After six weeks of monotherapy, radiological evaluation showed near complete remission of metastatic lesions in the lungs and lymph nodes and a good partial remission in the liver. However, the patient experienced elevated liver enzymes (AST and ALT), so MBZ was temporarily stopped and then started at half the dose, with the patient reporting no ill effects. Liver enzymes normalised and a subsequent round of CT scans confirmed the initial disease response. After ceasing treatment for approximately three months, the patient developed brain metastases that were treated with radiotherapy, following by evidence of disease in the lymph nodes. MBZ treatment was not recommenced following the discovery of the brain metastases or in subsequent disease progression. A further five patients have been treated, with one experiencing a minor remission [Private communication from Peter Nygren].” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/

  6. D, you have so many great suggestions on your site!

    Love to hear your comments about dandelion root. This one sounded out there, though a phase 1 trial has been given the go ahead. In preclinical research single agent treatment resulted in tumor stasis.

    Also love to hear what your opinion is of liposomal formulations. There is an evolving technology base that perhaps could be applied to a very wide range of treatments. Wonder whether liposomal vitamin C with a targeting mechanism could be added on top of IV vitamin C to push the tumor into a total ROS crisis.

    Best Wishes

    1. Hey J,

      Very nice to hear from you. I think dandelion root is indeed relevant, but in order to comment on that I will have to look in to it in details. I will do that asap. Also interesting to hear about phase 1. Regarding liposomal formulations, I was very excited some years ago. I think we also discussed on Compass. Yet, I haven’t heard anyone reporting outstanding results after using them (Vitamin C, Resveratrol, etc.). Have you heard of any? In theory I like the idea and I think I added a link on the Vitamin C post, to a website of a researcher who is expert in making the liposomal version.

      Kind regards,
      Daniel

    2. hi Jcancom,
      never heard about dandelion root being potent. Its funny – i keep seeing this plant where i live, it seems to me very invasive. will check – and maybe dig deep :D:D:

  7. Sorry here are some references about dandelion root.

    This one impressed me. PMID: 27564258
    Report suggests anti-cancer effects in pancreatic, colorectal and other cancers.
    I found Figure 4B especially impressive: the tumor has essentially stopped growing.
    Such a strong result for a single agent treatment is encouraging.

    Here’s some more of the background.
    https://www.cancertutor.com/dandelionroot/

  8. Hi Daniel, I am not on mebendazole regularly (although I do sometimes have some.) However, looking at this wonderful information you have put up on this page, perhaps I should be taking albendazole for advanced ovarian cancer?
    I was taking cimetidine but I stopped after somebody told me it was an oestrogen driver.
    I am rattling with all the drugs and supplements I am taking. I don’t know if it is all these drugs, potions and tablets that is making me feel so bad every day, or if it is the cancer progressing. My CA125 is rising constantly, but it always has and I have managed long spells without treatment. How can I work out if it is all the drugs that are making me feel bad?
    I have reduced all the supplements I was on because I felt there were too many. I was taking over 100 tablets a day at one point which is just mad I think. Does anyone agree?

    1. Hi Helene,

      Thank you.
      It depends what you mean by working.
      My interpretation of a working treatment approach is that it will at least extend the life of the patient (while not reducing its quality). We did used Mebendazole and Doxi and we felt it helped a lot and had their own contribution to the extra years we’ve gained.

      Kind regards,
      Daniel

    1. Thank you for the feedback dr. Nuri. Please keep us up to date with the results, since this info will help many other people. Also, if you are aware of any other treatments with potential, we here are always glad to know them and research them.

      Kind regards,
      Daniel

  9. It seems there is a rebound effect once the mebendazole is stopped, tge cancers seemed to come back. If I start taking it does that mean I will have to remain on it indefinitely?

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