Some of the most effective treatments in my opinion

Here is a list of some of the most effective anti-cancer treatments I am currently aware of:

  • Salinomycin – a potassium inophore that will interfere with intracellular potassium. If delivered in the right dose, there is a high chance of affecting the cancer cells while not affecting the normal cells. It has been used on humans with great results. This treatment needs to be administered via IV. It will be relevant for most cancer types, regardless of their origin or metabolism, but, as I understand it, the epithelial cancers are showing the highest response. There are very few centers where it is being administered:a few in Germany and a few in Central America. The (material) cost will be in the range of 3000 euro for one cycle (assuming that the base Salinomycin is used which is 10x more expensive than the salt version). If performed in clinics in Germany it may be possibly in the range of 5000 – 10.000 euro for one cycle and even cheaper if the salt version is used. In Latin America I have heard of >20.000 euro prices but they would also combine it with 3BP and others, and they would also be more much experienced compared to the German clinics. A cycle consists out of about 12 IVs.
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  • 3-Bromopyruvate – a glycolisis inhibitor which is relevant for most types of cancers that are visibleon PET/CT scans (i.e. tumors that are using mainly glucose as a fuel). Discovered by Dr. Ko at John Hopkins University in USA. Has been used on humans with great results. The cost can be relatively cheap in Germany, about 150 euro/IV but the experience of the German clinics with 3BP is limited so far. The best would be to join one of the clinics that are supported by Dr. Ko since those are the clinics that have some of the best results with it. In those clinics 3BP is only a part of a more comprehensive treatment that may cost >15.000 euro/month. This treatment has been discussed on this website in details.
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  • Diflunisal – this is a much less known treatment, indeed almost unknown, and will be discussed on this website in details. To my knowledge there is only one clinic in the world using it and that is in Germany. That place is Unifontis and the clinic is part of a University hospital. Prof. Drevs is the lead there – a very nice and knowledgeable man. The Diflunisal anti-cancer effects have been discovered by another German professor Werner Kreutz about 15 years ago. I met a very nice American man who was treated with Diflunisal at Unifontis. He had metastatic pancreatic cancer and in one month he was cured. As with 3BP , I believe this treatment is relevant for tumors that are visible on PET since it works only if the tumors have low extracellular pH. But, since most of the tumors have that characteristic this should be relevant for many. But the drawback is that a required three week treatment costs about 30.000 euro. Update April 2016: I have learned that dr. Drevs has changed the treatment schedule and as a result the cost drooped to about half of the initial one.
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  • Anti PDL1 & Dendritic Cell therapy – this combination seems to have great potential and its strength is that you do not need to perform many administrations to see a potential response. The idea is to “uncover” the cancer cells with the anti PDL1 and at the same time push the pedal of the immune system with the Dendritic Cell therapy. One treatment may cost around 5000 euro and it may require a few rounds. The drawback is that there is a chance to trigger an auto immune disease that may even be lethal. The chance is small, but it is real. One of the best places to perform such a treatment is in Germany with dr. Nesselhut.
    Update on April 2016: I do not see this as a top option anymore given that I heard many actually starting to progress after starting DC and or anti PD1/PDL1 therapy. It is not only one person but several so a pattern starts to occur.
    Conclusion: relevant therapy idea but expensive and risky so only try if no other options are left
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  • Proton Pump Inhibitors – this treatment is great, I think. Why? Because is very accessible and highly relevant for all the tumors that are relying on glucose as a fuel. These tumor cells are producing a lot of protons (acidity) that they need to push out of the cell. For reasons I will discuss latter, it may even be interesting to alternate this treatment with 3BP treatment. The idea of the treatment strategy is to block all the channels through which the tumor cells are pushing away the protons. And like putting a potato on the exhaust pipe of a car, at some point the engine will stop working if the smoke (in this case the protons) can not go out of the cell. I will discuss this strategy in more details on the website but I suggest that if you find this interesting you contact prof. Salvador Harguindey. Their foundation may support some patients with such treatment strategy. Yes, it is not only theory but it has been effective in killing cancer in patients. For more discussion on thsi subject please click on the following link http://www.cancertreatmentsresearch.com/?p=1178
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  • Induced Hypotiroidism – this strategy has a good potential and is easy to implement and is cheap. See the discussions on this page.
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  • TACE: Trans arterial delivery of various anti-cancer elements and immunotherapies – there are various places where this can be done. There are many people who may respond to such local treatments. Best places in the world to perform such a treatment are through Dr. Jason Williams in USA region and Prof. Vogl in Europe. I do not know what the prices are with Dr. Williams but with Prof. Vogl, the price is usually 4000 euro for one administration. In general you need multiple administrations for a chance to response. Both Dr. Williams and Prof. Vogl are impressive people and doctors, in a positive way.
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  • ElectroMagnetic fields
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  • Curcumin IV
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  • Quercetin IV
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  • Phosphoetanolamine
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  • Phlorizin

More treatments will be discussed asap.

Others that may be very relevant but have limited science behind:

  • Lovastatin & Interferon – this is a very interesting treatment strategy, patented and performed at a clinic in US, with an outcome that seems to be impressive. I do not know anybody who was treated at this clinic but because of the science behind it, I have somehow a good feeling about them. The results theyclaim on their website are very good. I will investigate this further. The price is unknown to me.
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  • Immunepheresis – also a very unknown treatment. Immunepheresis works by physically removing – from the bloodstream- inhibitors that are directly produced by cancer cells. Those inhibitors block the immune system and therefore protect the cancer. Again this treatment is done in Germany. Essentially, what they are doing is to clean up the blood using some very special filters toremove compounds of less than 120,000 daltons molecular weight. Here is a quote from the patent: “the patient is pheresed to selectively remove soluble receptor/inhibitors to soluble tumor necrosis factor receptor-1 (“sTNFR-1”), soluble tumor necrosis factor receptor-2 (“sTNFR-2”), soluble interleukin-2 receptor (“sIL-2R”), soluble interleukin-1 receptor (“sIL-1R”), soluble interleukin-6 receptor (“sIL-6R”), or soluble interferon-gamma receptor (“sIFN-gammaR”). These can be removed by binding to the cytokine, an epitope thereof, or an antibody to the receptor. These can be immobilized in the filter, in a column, or using other standard techniques for binding reactions to remove proteins from the blood or plasma of a patient. The patient is preferably treated daily for three weeks, diagnostic tests conducted to verify that there has been shrinkage of the tumors, then the treatment regime is repeated.” As you can see the treatment is relatively intensive and the cost is in line with that. To my knowledge, the cost may be up to 50.000 euro for a treatment cycle. On the positive side, it may be relevant for most and it is claimed that 60% of the patients have >50% tumor reduction. The treatment clinic can be contacted here https://www.int-imm-foundation.com/

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18 thoughts on “Some of the most effective treatments in my opinion

  1. Hello Daniel.
    Very helpful site.
    My wife diagnosed with glioblastoma 4.Presently on chemotherapy.
    What additional treatment would you recommend.
    We live in Canada
    thank you

  2. Hi Stan,
    Here are a few things I would consider:
    – contact dr. Akbar Khan at Midocor in Canada to see what are the options they have (I think they were using POH which seems to be very relevant for glioblastoma – there is a section on this website on that)
    – i would consider buying such a device http://www.cancertreatmentsresearch.com/?p=865
    – finding a place to be treated with Salinomycin at the same time with chemo to increase sensitivity of cancer cells to chemo and/or kill CSC
    – DC with New Castle http://www.cancertreatmentsresearch.com/?p=643 some but not all had good results with such treatment
    – a cocktail of repurposed drugs (I would need to look up for that or maybe you already know that)

  3. Hi Stan, that was in my mind to share with you. So I do like that.
    CUSP9 includes aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, sertraline, ritonavir.

    Next to that I would also have a look at the following info that may be relevant to you:
    – Chlorimipramine, the keto diet and Boswellic Acid
    – Noscapine inhibits tumor growth in TMZ-resistant gliomas http://www.ncbi.nlm.nih.gov/pubmed/21925789
    – Autophagy inhibition improves the efficacy of curcumin/temozolomide combination therapy in glioblastomas http://www.ncbi.nlm.nih.gov/pubmed/25542083
    – Chloroquine enhances temozolomide cytotoxicity in malignant gliomas by blocking autophagy http://www.ncbi.nlm.nih.gov/pubmed/25434381
    – Tetanus Vaccine Boosts Cancer Therapy http://www.nbcnews.com/health/cancer/tetanus-vaccine-boosts-cancer-therapy-n321596
    – Asparagine depletion potentiates the cytotoxic effect of chemotherapy against brain tumors. http://www.ncbi.nlm.nih.gov/pubmed/24505127
    – Antagonist drug Emend halts brain tumor growth http://www.news-medical.net/news/20130320/Antagonist-drug-Emend-halts-brain-tumor-growth.aspx
    – Canadian researchers break blood-brain barrier with new ultrasound treatment http://www.ctvnews.ca/health/canadian-researchers-break-blood-brain-barrier-with-new-ultrasound-treatment-1.2648878
    – Blood glutamate scavengers (Oxaloacetate) prolong the survival of rats and mice with brain-implanted gliomas. http://www.ncbi.nlm.nih.gov/pubmed/22297683 Glutamate transporters in the biology of malignant gliomas. http://www.ncbi.nlm.nih.gov/pubmed/24281762
    Most of the above are accessible to anyone in terms of price and availability.

  4. Hi Daniel,
    First of all, keep up the great work you are doing. I am new to this blog but I was wondering if you have any experience with using Salinomycin in conjunction with herceptin (Trastuzumab) for a cancer that is 80% Her2+. The patient is already on a combination of Herceptin and Paclitaxel (treatments every 3 weeks for about three months, second treatment is today). Specifically, do you known anything about the effectiveness/contraindications of Salinomycin in conjunction with herceptin. Herceptin is a trageted therapy that induces the immune system to attack the cancer so I am not sure if Salinomycin will have the same effect as it does with standard chemo.
    Thank you in advance
    Gregg

    1. Hi Gregg,
      Thank you. I am not aware of a negative interaction between Herceptin and Sal. Actually Her is even proposed to be used as a guide for Sal loaded nano particles http://www.ncbi.nlm.nih.gov/pubmed/23086911
      Through its action, Sal will further trigger the immune system by over activating T cells.
      Sal seems to work best with chemotheraphy or 3BP, where chemo is de bulking and Sal is killing the resistant population. If the immune system of the patient is in a good condition, Sal may even lead to debulking by triggering a general immune reaction.
      I hope this helps.
      Kind regards,
      Daniel

  5. Hi Daniel
    I am the patient Gregg wrote about- his wife. First of all I hope your wife is doing well. Best wishes.
    We haven’t been able to get salinomycin. Even connections to people in research labs hasn’t helped so far. So “worried” about side effects, even though I’m on chemo…
    1) Do you know names of places /clinics in Europe where it is possible to get it?
    2) From your research, did you find any other substance that goes after stem cells that’s strong but easier to get?
    To share: From our research we found that broccoli sprouts and ginger (heated) kills stem cells. Many scientific reports
    Thank you

  6. Hi Gregg’s wife :),

    My wife is fine, thank you for asking – we have our ups and downs but we are trying to take the best out of every day. I hope you are fine too.
    1) Europe’s best and probably only place would be Heidelberg Cancer Center. Just contact the prof. in Heidelberg, teh first author of this paper: http://www.ncbi.nlm.nih.gov/pubmed/23251084 you will find his e-mail address with Google. If you dont just let me know and will search that for you.
    2) Besides salinomycin, four other compounds were identified (nitazoxanide, niclosamide, closantel and pyrvinium pamoate) http://www.nature.com/bjc/journal/v114/n12/full/bjc2016152a.html Next to this most of the drugs targeting mitochondria seems to work against CSC, including metformin and doxycicline. Many natural extracts are known to also target CSC but the challenge of those is usually the bio availability. Curcumin is an example on this line.
    Thank you for sharing. That is always helpful.

  7. Great….
    All the good ones are out of reach for the normal mortals and require repeated application that may or may not succeed despite the cost.
    I feel i am failing…
    How can i hope to help others in the future if i can’t get my mother well now?!
    Thank you dear Daniel for all this information you’ve given us and the huge help.
    Hope you had a better weekend,
    ALex

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