Shutting Down the Power House of Cancer

Dear Friends,

Sometime ago, I promised to address this strategy, Shutting Down the Power House of Cancer, in more details (Ref.). Although I was looking forward to do this, it took some time to do this as I am working in parallel on three different directions, all connected. Those are the Blog (lately mainly communication in the background with people that need help), the Foundation (advancing both it’s major projects, one related to 2DG and the other related to pH in cancer), and starting up the Supplement Company (required to generate financial sustainability – the intention is to have the first products available sometimes in March 2020).

Today, I succeeded to find time to share some thoughts with you on strategies to fight cancer, with a specific focus on “Shutting Down the Power House of Cancer”, a metabolic approach to fight cancer. For some of the constant readers and friends on this website, some of the statements below may not be new. Yet, for the clarity and continuity of the discussion I need to make again some points. Thank you for your understanding.

Multiple Strategies to Fight Cancer, Chose One and Do It well

As we often discussed on this website, like any other problem, cancer can be viewed and addressed from various angles. In this way, looking for example through the lens of immune system, we could consider to address cancer as an immune system issue. In this case we will try to address all the mechanism that would help to enable or activate the immune system so that it can do it’s job and remove tumours. Another perspective we could consider, may be the hormonal perspective and try to fight caner by addressing relevant hormonal mechanisms. Or we could think of creating a pro-oxidant or an anti-oxidant pressure against cancer. Or we could decide to acidify cancer cells internally and suffocate them with their own “smoke” (Ref.). There are many ways we could fight cancer and these are just a few examples.

All these perspectives, or let’s call them strategies, are focused on attacking weak points of cancer. These are points, or mechanisms, on which cancer cells are heavily relying for their intensive activity. Now that we are aware of many such approaches, the major challenge is not anymore to find ways to beat cancer. Instead, it is about how to consolidate them in wise strategies, given a specific patient case, and how to apply them in order to increase the chance for their effectiveness.

Several such strategies that I intend to address in various posts to come are depicted in the figure below, indicated by the Blue-coloured hexagons. Aspects that I see them more as supportive and that would be addressed in parallel with the main strategies, are represented by Mustard-coloured hexagons. The strategies highlighted in the hexagons do not represent just one mechanism but multiple mechanisms clustered under the same umbrella. For example, “Inhibiting Cellular Building Blocks” includes anti cholesterol production too, previously discussed on this website. Mechanisms such as authophagy and angio-genesis are included in the “Deplete Nutrients” strategy. Nevertheless, with this figure, I did not intended to cover all possible strategies to fight cancer. Instead, my purpose was to create an overview of the major strategies I find relevant and I like to address in various posts to come.

The strategy we chose should be inline with the core treatment we decide to have. For example, if we go for Chemotherapy or Radiotherapy we may chose the pro-oxidant strategy as our Central strategy, and build our treatments around that, while if we go for angio-genesis inhibitor drugs, we may want to focus on the “Nutrient Depletion” strategy as top priority. 

The idea is to align/integrate our core treatments (often defined by oncologists) with a Central strategy that is likely to add more value that the core treatment alone. If there is no core treatment that we are planning to use, we will chose a Central strategy and try to make that as strong as possible including repurposed drugs and supplements (oral and intravenous when possible). Therefore, I think what is essential is the fight against cancer is to be consistent, coherent and have priorities. 

Integrating treatments in a coherent manner, to create cocktails, it is actually a trend in the oncology industry, also reflected by many of the recent clinical trails that now include two or more drugs. It is a trend generated by the need to improve the current treatment methods that have limited effectiveness.

Furthermore, I am constantly stressing the point about consistency, coherency, and priority because as cancer patients become more and more aware of the potential to fight cancer as a metabolic disease, there is a tendency for the patients to try inhibit all possible survival pathways at the same time. However, in reality this is difficult to achieve if not impossible because of two major reasons: first, it is likely we do not know all the surviving pathways of cancer; second, to get a fair chance for inhibition, each mechanism requires high dose of supplements/drugs, and that multiplied with the number of mechanisms to address leads too a very high number of capsules/tablets that would be impossible to take for most patients. As a result, patients trying to address all escape routes, will end up with a low dose of supplements/drugs for each target that may not hep much.

This is why, while in theory I would like to address everything at the same time, in reality it would help people to have a logical way to identify priorities as a function of the treatments given by their oncologist or a function of their choices. On this line, a better route in my view is to select one strategy that is relatively well understood scientifically, which would address a key mechanism in cancer, and address that seriously with higher doses of drugs and supplements. If there is space for more drugs and supplements, and the patient can take more tablets, we can include other strategies that work well together with our selected and Central strategy, as I will discuss below. 

Shutting Down the Power House of Cancer as a Central Strategy

One (metabolic) strategy that could be chosen as the high-priority strategy is to “Shut Down the Energy Engines” responsible for the energy production in cancer cells. In this case we just need to focus on “shutting down” the energy factories of the cell. Fortunately, this is not very complex as there are only two energy factories inside the cells:

  • respiration via mithocondria 
  • fermentation in the cytosol 

Once I would chose this strategy and mechanisms as a priority I prefer to address this strategy intensively, and place the inhibition of fatty acids, glutamine and glucose on a lower priority level. This is because, glucose, glutamine and fatty acids require functional engines (respiration and fermentation) in order to be converted in energy (ATP). So, for example if we shut down the respiration (the engine), there is no way glutamine (the fuel) will be converted in to energy.

(I should note here, that when we speak about “inhibition” or “shutting down” that will not happen literary, instead in general the activity of the specific target will be reduced only, but to a level that seriously affects cancer and not normal cells)

Indeed, various studies have demonstrated that concomitant inhibition of fermentation and respiration is lethal to most cancer types but not to normal cells. Here are just a few examples of those studies: 

  • Fermentation inhibitor Gossypol + Respiration inhibitor Phenformin: ALDH inhibition using gossypol, combined with mitochondrial complex I inhibition using phenformin, resulted in up to 80% depletion of ATP production in cancer cells, accompanied by significant growth regression of NSCLC tumors in the animal xenograft model, while normal cells do not have a loss of ATP production (Ref.)
  • Fermentation inhibitor + Respiration inhibitor Metformin: Dual Inhibition of the Lactate Transporters MCT1 and MCT4 Is Synthetic Lethal with Metformin due to NAD+ Depletion in Cancer Cells (Ref)
  • Fermentation inhibitor Diclofenac or Diflunisal + Respiration inhibitor Metformin: Combined Metabolic Targeting With Metformin and the NSAIDs Diflunisal and Diclofenac Induces Apoptosis in Acute Myeloid Leukemia Cells (Ref.)
  • Fermentation inhibitor Diclofenac + Respiration inhibitor Metformin: Combined Modulation of Tumor Metabolism by Metformin and Diclofenac in Glioma (Ref.)
  • Fermentation inhibitor Oxamate+ Respiration inhibitor Phenformin: Synergistic Anti-Cancer Effect of Phenformin and Oxamate (Ref.)
  • Fermentation inhibitor Syrosingopine + Respiration inhibitor Metformin: Syrosingopine sensitizes cancer cells to killing by metformin (Ref.)
  • Fermentation inhibitor 2-Deoxyglucose + Respiration inhibitor Metformin: Induction of Apoptosis by a Combination of 2-Deoxyglucose and Metformin in Esophageal Squamous Cell Carcinoma by Targeting Cancer Cell Metabolism (Ref.)
  • Fermentation inhibitor 2-Deoxyglucose + Respiration inhibitor Metformin: Targeting cancer cell metabolism: the combination of metformin and 2-deoxyglucose induces p53-dependent apoptosis in prostate cancer cells. (Ref.)
  • Fermentation inhibitor Vitamin C + Respiration inhibitor Doxycycline: Vitamin C and Doxycycline: A synthetic lethal combination therapy targeting metabolic flexibility in cancer stem cells (CSCs) (Ref.)
  • Fermentation inhibitor Vitamin C + Respiration inhibitor Doxycycline and Azithromycin: Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs) (Ref.)
  • Fermentation inhibitor Vitamin C + Respiration inhibitor Berberine: Dodecyl-TPP Targets Mitochondria and Potently Eradicates Cancer Stem Cells (CSCs): Synergy With FDA-Approved Drugs and Natural Compounds (Vitamin C and Berberine) (Ref.)

Therefore, combining inhibitors of fermentation and of respiration is one of the very relevant strategies to fight cancer. An actionable plan along this strategy can be put in place relatively fast given that we (contributors to this website and myself) already collected long lists of accessible fermentation inhibitors and respiration inhibitors shared on this website at the following links:

In order to try addressing each of these two mechanisms effectively, I would consider addressing them with at least 2 or 3 inhibitors each, at the same time, using a dose that we expect it may be effective in reaching the goal. In my view, looking at drugs and supplements that can be take orally, we do have more effective tools to inhibit respiration compared to fermentation. This is why, I would use two/three respiration inhibitors and a larger number of fermentation inhibitors (including glucose transporter inhibitors). Below is a picture showing a basic strategy to shut down the energy engines.

Note on the figure above:

  • For each drug or supplement, only the major targets relevant to this strategy are mentioned (otherwise most of the drugs and supplements have multiple targets, e.g. Metformin also affects fermentation, Canagliflozin also affects mitochondria) 
  • Blue-coloured hexagons represent repurposed drugs while Moustard-coloured hexagons represent natural extracts

Example of daily doses that I would consider on the above (oral administration):

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I would always start each drug an supplement step by step towards the target dose, and not all at once. For example I would add one new drug or supplement every two days (to identify any undesired reaction if any) and increase towards the target dose during e.g. two weeks.

As indicated in the figure below, in order to further improved the above strategy, I would also consider the addition of intravenous administration of:

1. High dose Vitamin C as discussed here 
2. Metronomic 2DG as discussed here 

In case this strategy is combined with chemotherapy, I would stop all fermentation inhibitors 3 days before chemo (including Metformin/Berberine as it also affects fermentation but not Doxycicline or Atorvaquone), and restart them in the day of chemo, starting with Metformin during the chemo day, and the others building them back up step by step. The first to restart are re-purposed drugs, and about 3 days after the plant extracts such as Quercetin and EGCG. Omega 3, I would keep it ON continuously.

In case this strategy is combined with radio-therapy, I would stop all plant extracts 3 days before radio and restart them about 3 days after. All the others, including Omega 3, and specifically respiration inhibitors, I would keep ON.

Note that the combination of Meformin and Syrosingopine has been explored intensively during the past months as some of the patients around the world are implementing this combo and some on our forum and the Inspire forum are possibly seeing positive results (Ref.).

If High Dose Vitamin C treatment is performed, I would avoid taking GLUT1 inhibitors (such as Caffeine and others) several hours prior to Vitamin C administration since GLUT1 transporters are required for the absorption of Vitamin C inside cancer cells (Ref.).

Extending “Shut Down Energy Engines” Strategy

In the Figure below, “Shut Down Energy Engines” strategy is depicted at the main strategy, and at the right side, in order of priority there are other strategies that are considered as having good potential to support our main strategy. Of-course, this picture would change if we would chose another Central strategy instead of “Shut Down Energy Engines”.   

If I would look for ways to further improve the above strategy, the first strategy to consider as a good addition is the strategy to acidify the cancer cells. This strategy has been specifically discussed here.

Adding “Acidify Cancer Cell” strategy to enhance “Shut Down Energy Engines” strategy

Why I think this is a good idea? The strategy focused on “Shut Down Energy Engines” included respiration inhibitors. Inhibiting respiration effectively, redirects energy production on the fermentation path, and if that will still be active (i.e. not effectively inhibited by our supplements and drugs), cancer cells will produce large amount of protons (acidity) that need to be exported in order to avoid the cancer cell death. In other words, it is possible for cancers to use fermentation as an escape route. If this is the case, inhibiting the transporters/mechanisms used by cancer cells to push the protons outside the cell will lead to accumulation of protons (acidity) inside the cancer cell, shut down of fermentation and finally cancer cell death.

It makes also very much sense to consider “Acidify Cancer Cell” as a next strategy to add, given the large overlap of drugs and supplements required for the two strategies, i.e. for “Shut Down Energy Engines” and “Acidify Cancer Cell”. For example, Metformin, Doxycicline, Quercetin, Statins, Syrosingopine, Diclofenac are already known as cell acidifies. So it would only required at least one, possibly two other drugs to address “Acidify Cancer Cell” strategy relatively well. Those repurposed drugs are:

  • Amiloride (as a Na/H exchange inhibitors) read more here on the doses (Note: when using Amiloride, blood levels of potassium have to be verified every two weeks to make sure it doesn’t go to dangerous levels)
  • Acetozolamide (as a CA IX inhibitors) read more here on the doses
Other approaches that could enhance “Shut Down Energy Engines” strategy

Increasing intracellular acidity also inhibits fermentation (Ref.), inhibits β-Catenin (Ref.), inhibits mTOR (Ref.) and triggers authophagy (Ref.).  However, if the strategies above are addressed well, tumours will be destroyed regardless of autophagy. Nevertheless, if one would want to also address autophagy it would make sense to consider Hydroxychloroquine at about 200mg/day (due to it’s long half life, taking it even every few days make do it’s job). Normally, Hydroxychloroquine has serious challenges in reaching the tumor location due to the typically acidity around the tumors combined with it’s weak-base profile – acidity around the tumor will protonate Hydroxychloroquine. However, when combining Hydroxychloroquine with the strategies above protonation may not be the challenge anymore, since the fermentation is reduced or protons accumulated inside the cancer cells. Note that in my view, Hydroxychloroquine is part of the Nutrient Depletion strategy.

Going further on extending “Shut Down Energy Engines” strategy, we could also consider adding at least part of the “Cellular Building Blocks inhibition” with a specific focus on addressing Cholesterol production. This also makes sense to consider in extension of “Shut Down Energy Engines” strategy since again, there is a good amount of overlap of the supplements and drugs used for the two strategies, i.e. “Shut Down Energy Engines” and “Cellular Building Blocks inhibition”. More specifically, Cholesterol production inhibition also includes Satins, Metformin, Doxycicline, Omega 3, Berberine as discussed here (Ref.). To further complete this strategy, I would consider adding HCA and Dipyridamole. Dypiridamole and HCA daily doses are discussed here (Ref.).

In summary, an extension the “Shut Down Energy Engines” strategy, would contain

  • at least on of the proton pump inhibitors Amiloride or Acetozolamide, preferably both
  • the authophagy inhibitor Hydroxychloroquine 
  • HCA and if possible Dypiridamole 

Finally, regardless of the treatment strategy, in parallel to the central strategy, I would always consider using drugs and supplements to

  • address parasites and inhibit fast cell division, such as Mebendazole 
  • reduce inflammation and inhibit metastasis such as Curcumin, baby Aspirin and Olive Leaf Extract
  • support vital organs and immune system such as Vitamin D, Milk Thistle and Astragalus

Disclaimer

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

Please read an extended version of the Disclaimer here: https://www.cancertreatmentsresearch.com/?page_id=1794

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96 thoughts on “Shutting Down the Power House of Cancer

  1. Happy New Year!!!

    My best wishes for you all, good health and lot’s of love.

    Thank you all for everything.

    Thank you Daniel for all your relentless work to fight off this huge problem.

    Excelent presentation this time.

    Hugs.

    Alex

      1. Daniel you are amazing. Thank you is not a big enough word nor does it carry enough meaning. In your limited spare time could you possibly help me? My 28 year old daughter has Ewing’s sarcoma in her pelvis…not operable… She’s done 35 proton radiation sessions and starts round 11 of 14 on Monday. I have had her taking the COC drugs for 3 months so far to aid her journey. She also takes:
        LDN
        Acycolovir
        Resveratrol
        Loratadine
        EGCG
        Aspirin
        Reishi Mushroom
        Omega #
        Garcinia Combogia + Alpha lipoic acid
        L-Lysine
        Luteolin
        Curcumin
        (deciding about quercetin and berberine)

        Sarcomas are nasty….Would you add anything else?
        Thank you so much,
        Robin

        1. Dear Robin,

          I am so sorry you have to deal with this challenge … indeed sarcomas are challenging and in order to give you a deeper answer, I would need more time. At this moment I am travelling, and will have very little time during the next 1.5 weeks. After that (if you could please remind me) I should be able to find the time to look again closer to sarcomas and see what would be best in my view.
          Until than the only point I would make is that fermentation has to be specifically addressed as much as possible. That means more repurposed drugs on that line if possible and higher dose of supplements addressing fermentation. Example of drugs and supplements addressing fermentation are here https://www.cancertreatmentsresearch.com/drugs-and-supplements-that-block-fermentation-and-help-fight-cancer/

          Kind regards,
          Daniel

          1. Hi Zednek,
            What does diclofenac do? Which pathway does it block? She takes 20mg of melatonin and 500mg of berberine. I don’t know why I left those out of above list. Thanks for your help!
            Robin

          1. Gosh Jonah, after 7 months of research I’ve yet to see the article you linked. Thank you so much!! And I happen to have sulforaphane in the house because I take it. It’s broccoli sprouts right?
            Thanks again for taking the time out of your day to help.

            Robin

            1. Hi Robin,

              Indeed, the best source for Sulforaphane is broccoli sprouts. A therapeutic dose starts at approx 60 grams of the sprouts. It’s a lot to eat but easier to ingest in a smoothy. Or a combination of sprouts with supplements and/or powder: – Organic Broccoli Sprout Powder (Health Ranger) – Avmacol® – NanoPSA (a blend of NanoStilbene™ and Broccoli Sprout Extract).

              In the forum I’ve posted instructions on how to sprout broccoli:
              https://www.cancertreatmentsresearch.com/community/head-and-neck-cancer/head-and-neck-squamous-cell-carcinoma/#post-2102

        2. FYI: About curcumin
          Formulations for higher bioavailability of curcumin:
          BioCurc®
          CurcuWin®
          Longvida®
          CAVACURMIN®
          TetraCumin-QR
          Curcumin C3-complex® + Bioperine(Possibly not as effective as products that use above mentioned nanotechnologies and formulations.)

  2. Hi Daniel.
    What a great way to start the year with an exceptional article as always, this article reinforces my belief in the protocol that I have envisioned for my wife, really magnificent clarity of presentation, my dream for 2020 is mitometformin + syrosingopine + amiloride hexamethylene + IV EGCG + IV Quercetin to achieve all these formulations would take the protocol to a higher level.
    Thank you Daniel for your dedication and work I think heaven has already been won by you ,your wife will be proud of you watching from heaven

    1. Dear Marcos,

      You are too kind with your words. Thank you so much. Where do you get your Quercetin IV? There is one source in Ukraine ready for IV but I think it has a little too much polyvinylpyrrolidone inside for high dose, yet usable.

      Kind regards,
      Daniel

        1. Hi Marcos,

          Here is the info I received from a doctor using it: “We used 1 cc ethanol per 10 mg of tetrandrine with 1 cc dmso and tiny bit kremfor el. In 175 cc saline.”
          And here is a Chinese study given Tetrandrine IV to patinets: “Patients randomized to the treatment group also received tetrandrine (Yixian®, Jiangxi Yintao Pharmaceutical Co., Ltd. (Fuzhou, China) 150 mg in 500 mL NS via slow i.v. infusion for 10 days.”https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3614858/

          I hope this helps.

          Kind regards,
          Daniel

  3. Hi Daniel,

    First of all thank you and congratulations for summarize all the info in this post.

    I´d like to ask you if flarin (ibuprofen) is too a fermentation inhibitor as diclofenac ; i know that flarin is a good COX inhibitor but i don´t know anyrhing else. Would you change flarin for diclofenac with NED situation?

    Thank you

    Healthy new year

    1. Hi Inabari,

      Thanks you! Happy and Healthy New Year!

      For NED I would not focus so much on fermentation inhibition, but more on inflammation. In this context, and given that Ibuprofen may have lower side effects (but also less powerful), I would go for Ibuprofen.

      For active disease, I would better go for Diclofenac (if is to choose between the two) and would indeed focus on inhibiting fermentation (next to addressing inflammation).

      Kind regards,
      Daniel

  4. Thank you so, so much for this! I am one who has been lost in the vast array of available drugs/supplements, unable to discern which are more valuable than others at this point in time. I started with the “throw the kitchen sink” at it approach which resulted in an enormous amount of pills and insufficient dosages. As I read through past posts and comments, I was grateful for and amazed at the information provided, yet so overwhelmed. I felt like my lack of scientific background, knowledge and understanding hindered me from putting it all together. Thank you for providing clarity. I truly look forward to more information on additional strategies (soon, please? 🙂 and am excited for the launch of your Supplement Company.

    1. Thank you so much for your comment Janet. Nobody knows everything and we are all learning together, and hopefully help each other to learn faster. It’s normal to get to a point when it feels overwhelming but that is typically the point when we actually advanced a lot or knowledge. What follows after that is more and more clarity. I am sure that will happen to you too. I will do my best to address other strategies soon, but at this point I am working alone on so many subjects …. and starting up the supplement company becomes a priority that wold help me continue my activity in oncology (and even intensify it).

  5. Well, this is a master piece, Dan! Bravo! Is extiting for reading and really great idea you to find the way to bond different subjects and strategies – very skilful presentation. It is brilliant start of the year and I think your efforts will give many hopes for people in need. I know is hard to you to make tons of things alone but let me encourage you – you are not alone and if you need any help that can be done by fellow participants – please ask. 😉 La multi ani si sa fii sanatos. 🙂

    1. Thanks a lot for your kind words Milen. I think it can be better since for beginners may be a little heavy, but it was the best I could do in the available time. Thanks a lot for the offer to help. There are three areas where I need help: the blog, the foundation, the company. Maybe the best is to start thinking (or continue because you did offer a start a month ago) about how this website should evolve. After we agree on that, we can than agree on who will help where in order to move it to that direction. Or we can also consider to spin out some of the info from this website into an e.g. mobile application (in case we have people that could help with that) that could for example offer information on various strategies to be considered as a function of (general) patient data. I guess this should be the next step since I guess it starts to be too much content to navigate through. What do you think?

      1. Daniel: I’m a software developer, and willing to help out with technical as well as content editing/restructuring aspects.

        Technical: I noticed you are using wordpress on your blog; I have experience working on it. As also with mobile app development.

        Content:
        I do not think this is too much content to navigate through. Remember wikipedia… it is giant in terms of content.
        In my opinion, a mobile app is only any good if it offers some personalization based on user/patient’s profile (which the website can too for what it’s worth!)

        According to me, you need to separate the main content from it’s comments.
        So the website separates into two portions: A dedicated index of knowledge, and a discussion forum.

        The simplest strategy for you (since you are using wordpress) is to use wordpress pages for content created by key editors and admins of the website, and posts/comments for non-curated content (including patient specific threads). You can turn off comments on the pages to ensure that the information disbursal remains clean and to the point.

        If anyone provides great information in the forum, an editor can put it up on the relevant page with a link to the original discussion thread.

        1. That’s excellent advice, prashant! At the end of the articles, instead of offering to comment Daniel could offer readers the option to schedule an online appointment, free of charge, and directions and links to post questions/remarks, etc in the forum.

        2. Hi Prashant,

          Thanks a lot for your response and suggestions.

          1. I totally agree that Wikipedia an universe of information and people can still navigate through it. I think here it would be great to have a page containing a tool, that could guide the visitor through the content depending on his answers to specific questions, such as those mentioned by Milen in the comment here. Even for answering general questions, it’s a lot of work to structure the information in order to give the answers, but I think it would add good value to those that are new to various concepts we are discussing here and do not have the time to go through everything. I should probably check if there are plugins that can enable such functionality.

          2. It’s a good idea to consider switching off the comment option on the main posts, mainly because it may be a little unnatural the way we now have to places where we can comment. I actually considered this in the past, but so far I decided to keep it like this due to two main reasons:
          – the purpose of the comments on the posts was to have a place where we can discuss the content addressed by the post, while the purpose of the forum was to enable the visitors to start own topics as well as having a place where we can consolidate relevant content by specific subjects
          – if the forum-plugin would stop working for any reason (such as unprofitable activity of those making the plugin), we could at least have the main comment sections running and with the content available
          Nevertheless, the two points above can be reconsidered as I think it may be more simple to just have on place where we can comment and discuss.

          Kind regards,
          Daniel

      2. In reply to your comment PRASHANT offers some ideas (which I hardly understand due to lack of sufficient both technical and scientific knowledge). According the conversation that we started a month ago I still consider how to handle with the following obstacles: 1) I’m not familiar with all the information on the site and need a lot of time to read all information in the blog – articles (I recently counted the number of pieces – 132) and some thousand comments, actually – more than 4-year work in the blog but practically more than 6 years overall. To start with suggestions for some evolving or reorganization of the site I need to encompass the available info or at least to find out main vectors; 2) I did not use the forum till now at all so I have no any idea about the way it works let alone for the information that is shared there (which is related with p. 1); 3) because of 1) and 2) I still try to create an idea how I want to structure the subject (for example for spreadsheets) and the idea did not crystalize yet. You know – there is time for maturation. So, if I am not able to know what I want or how I imagine something I can’t start asking people. 🙂 Because their suggestions or answers will not help me properly although new ideas may arise. This does not mean I will not start ever just I need some fuel to shift the gear.
        This article above seems also as good starting point regarding possible structure.
        Probably a good idea from PRASHANT is that we need to find valuable comments (in both blog and forum) and to incorporate them in original articles – as update or something like this. In this way they will be even more detailed and will give more profound knowledge. Later we may fragment it to some pieces to make it simpler. In this way we’ll have information for both – people with basic knowledge that don’t want to go into the depth of the process and for people that want to be familiar with what’s going on there.
        Another good idea probably is to start with simple, basic questions: what follows if someone is diagnosed with cancer; what therapies are applied; what markers need to follow, etc. and to continue as Wikipedia – to go into the depth with hyperlinks of existing information on the site.
        If we agree that if this is the direction that we’ll head then probably it is good to ask beginners (in the matter of cancer – to some extent it includes me too) what do they need to see.
        I imagine some steps that follow the natural process, ex.: 1. what to do knowing there is diagnose of some cancer?; 2. what is core treatment and what is supportive one?; 3. what is relevant for this type of cancer?; 4. where I can find the drugs/supplements/clinics that I need for both – core and supportive treatment?; 5. How to know whether things are going well or not that good, what information to follow (markers, etc.)?; 6. How much time I need to apply some treatment? When I need to shift to another treatment? 7. If everything’s fine and there is significant or full recovery how to proceed further (diet, exercises, lifestyle, drugs, supplements, etc.)? 8. If nothing helps, what is “Last resort” option (other conventional or optional treatments)?

        1. Dear Milen,

          As mentioned in the answer of Prashant, I like your idea to start with simple, basic questions. When I find the time, I will check to see if there is any plugin available that could nicely address this and integrate it in this website.

          Kind regards,
          Daniel

  6. Could I ask about relation of Extending “Shut Down Energy Engines” Strategy (as was explained for Central strategy) – which of them should be ON and OFF with chemo and radiotherapy?

    1. Good question. It depends:
      – If the chemo is a weak base type, all can stay ON [Amiloride, Acetozolamide, Hidroxychloroquine (HCQ), HCA, Dypiridamole (DPDM)]
      – If chemo is weak-acid type, Amiloride and Acetozolamide should be OFF 3 days prior to chemo and can be restarted once chemo starts. In this case, HCQ, HCA and DPDM stay ON
      – If Radiotherapy, all can stay ON

      However if Chemotherapy or Radio is the core treatment, we will need to change a little the approach. In that case, in my view, the central strategy becomes the “Pro-Oxidant” strategy. Therefore, the priorities will change:
      – Priority 1 will be the “Pro-Oxidant” strategy (to be discussed, but that includes shutting down the anti-oxidant production)
      – Priority 2 will be the “Shut-Down Energy Engines”
      – Priority 3 will be “Acidify Cancer Cells”
      – Priority 4 will be “Nutrient Depletion”
      As the priority decreases, we become more selective and pick not all but only some of the most relevant drugs for the Central strategy and the core drug within that.

  7. Hi D,

    Thanks for a great post. I am slightly confused about “Nutrition depletion strategy”. Is this alternative fuel pathway other than fermentation and respiration? (e.g., glutamine, fatty acid, autophagy, etc.?)

    1. I think it is a different strategy; that by “Nutrition depletion” Daniel means denying the nutrients or building materials cancer cells need to make more cancer cells. Not the same as cutting off the energy to the cancer cells, although sometimes doing one thing also has an effect on the other.

    2. Hi Ksh.

      Thank you. When I speak about “Nut Depletion” I am thinking of various aspects to address. I would think of three major categories:
      1. mechanism and nutrients when the source is blood vessels (e.g. angiogenesis as a mechanism and glutamine etc. as nutrients)
      2. mechanism and nutrients when the source is tumor micro environment (e.g. lactic acid, acetate, etc.)
      3. mechanism and nutrients when the source is tumor intracellular space (e.g. authophagy, lipid droplets, etc.)

      Kind regards,
      Daniel

      1. I see. Thanks to both of you. Did you have any post on the nutrition depletion?

        My wife started using parp strategy 2 days ago, and I think nut. depletion may be suitable for us as we got to hinder DNA damage repair (slightly confused whether “shutting down the power house” or “nutriotion depletion” should be a priority”, but anything that would help.

      2. Hi Daniel, I am curious about the role of diet and fasting driven autophagy in the case of pancreatic cancer.

        1. A low carb and low protein (to reduce insulin, IGF-1) diet would seem to be beneficial to keep both glucose and insulin low. That leaves a high-fat diet. But high fat drives high CCK hormone which is implicated in the growth of pancreatic cancer. So, it seems even a low-carb/low-protein/high-fat diet would be detrimental.

        2. Secondly, considering short-medium fasting leading to autophagy, autophagy in a normal state can be protective against cancer. But cancer cells can use autophagy to their own benefit. So it is unclear if that would be beneficial, and my actually be a bad thing.

        Do you see any information around diet and fasting that might be suitable in the case of pancreatic cancer. ? Thanks very much.

        1. Hi Gmt,

          1. While I do not like anymore to be extremely strict about the diet I wold indeed avoid sugar, reduce carbohydrates (to avoid peak blood glucose levels), avoid red meat, and in hormonal cancers avoid fats.

          2. I would consider addressing autophagy with autophagy inhibitors only as part of a more intense treatment that may include e.g. radio, chemo, angio-genesis inhibitors, to put short term pressure on cancer cells while they are under attack due to treatments. On longer term I think it doesn’t make much sense since tumors have time to find other ways to access resources.

          Therefore, sugar and fats are key elements to avoid when dealing with pancreatic cancer. Having these in mind, you could use a nutritionist to guide you along this road.

          Kind regards,
          Daniel

  8. Wow Daniel, just wow! This may be your single most important article. I can’t thank you enough for your relentless work and I urge everyone that benefits from the knowledge on this site to MAKE A MONTHLY DONATION to support Daniel and his work to bring this knowledge to the masses. Very exciting to hear that you are pursuing your plans for the foundation and for the supplement company. I wish you a Happy New Year and best of luck with your projects!
    Regards,
    Carl

    1. Hi Carl,

      Thanks a lot! Very nice to hear again from you! Yes, even 1$/month would help so I can move towards financial sustainability. In that case I would be able to allocate most of my time to research and communication and share of info, instead of spending a lot of time to find ways to support my activity in the oncology space. Have a very Happy New Year dear Carl!

      Kind regards,
      Daniel

  9. Excelente Daniel time to visit PayPal to contribute.
    Can I ask you if you have heard about these? I’m looking at RE rosemary extract and especially at ursolic acid for AML and for MDS in order to change the micro environment in the bone marrow. Have you seen any research on this?
    Im on 3rd year MDS no chemo to date, preped for stem cell because Phoenix hospitals including mayo deny that CAR-T was approved for adults even when presented with printed evidence.
    Thx
    Richard

    1. Hi Richard, That’s odd about Phoenix and CAR-T. My onc in Sacramento Dr. Kiwan and also Dr. Toscano (UCD) is willing to give it to me (providing my insurance company would approve, it’s one of the most costly treatments) for relapsed lymphoma. Even though there are some questions about CAR-T and bugs to be worked out, eg the cytokine release syndrome etc. Several studies are being started even now on these things but it’s definitely being used (is approved).

  10. Hello Daniel and greetings to everyone, I stumbled on your website yesterday. A lightening bolt from an angel above led me to it. Even though I’m part nutrition scientist, much cancer healing information comes to me this way. So in the end I trust my instincts, intuition, heart, and the Universal forces leading me to this place of knowledge and connection. I have to say….thank you from the bottom of my heart and from the tippey tips of my brain! I stumbled on the “How to Starve Cancer” protocol (Jane McLelland) in June which was amazing. But now YOU, Daniel, the extent of your knowledge and willingness to share opens up my entire perspective, even wider. (note: how do you prefer donations? a paypal or other account?)
    I’ve had Stage IV relapsed follicular lymphoma now partly aggressive (grade 3A)– a poor prognosis in the medical establishment. I’ve kept it from growing out of control for 1.5 years and have refused a stem cell transplant for now, but now am on the brink of having a second chemo (R-CHOP) to knock back the fast-growing cells and have more of a chance to work on the stem cells. However, I keep finding strategies to help myself! And so we’ll see. I go each day and see what I can do, listen to my heart. My onc wonders why I’m not sick with B symptoms as I should have been a long time ago. But I do many of the starve cancer strategies, which now I find out, are only the tip of your iceberg of strategies. Your knowledge is so amazing here Daniel and all the informative posts and the forum/comments from everyone. I feel I’ve stumbled into an entire new universe than can help me! For example, I was at a loss why the DCA wasn’t helping me (the cancer recently progressed) but I see from your DCA post which things I’m doing wrong, why it’s not working, and why my glucose metabolism is suddenly haywire (bouts of hypoglycemia). I’ve fallen into the category you speak of here of doing too many things in too small of doses, some of them competing with each other. I need to get more focused on my strategies. And so will post more on this to get help. Mostly I want to thank you thank you thank you — Daniel and everyone here, for the journey we are on, and helping each other. It feels so very important, not just for ourselves and our own healing, but for others too. And for all the angels who are now helping us all. Happy New Year to Everyone!

      1. Hi Daniel,
        I wanted to post a question about some DCA issues, but I’m embarrassed to say, I went to the forum and couldn’t see where to start a new post! Sheesh. I’ve been taking DCA for 4 months, worked up to 25 mg/kg and suddenly now getting glucose/hypoglycemia issues — waking up with low blood sugar with symptoms. You mentioned that DCA can also impair our glucose metabolism. Past weeks I’ve been taking it hours before breakfast (during morning fast) but maybe the solution is as easy as taking it right before eating? For the first 2 months I took it after breakfast. I didn’t think it mattered that much with it’s long half-life. Thank you!

  11. Dear Daniel,
    Another amazing article for us in the new year! The time, organization and care you put into this is so appreciated and very helpful for people figuring out how to get started. We are forever grateful for your selfless service and work on behalf off all of us fighting the fight for ourselves and our loved ones.
    -Shanti

  12. Hi Daniel,
    I agree with everyone, that this is a HUGE important article, full of so much good information. I’ve read it 4 times already. I have a question on where DCA fits into all this. I thought it was a mitichondria disrupter (generally). Which category of your organization of strategy”cells” above does DCA fit into? Which category of strategy does it fit into. I’m rethinking all my strategies and want to get more focused.
    Thank you for all you do!

    1. Hi Adele,

      I did not included DCA because it is somewhere in between: it doesn’t truly inhibit fermentation and it doesn’t inhibit mitochondria (based on general knowledge). It’s enabling pyruvate get back on track, and in this way DCA is a kind of mitochondria activator https://www.ncbi.nlm.nih.gov/pubmed/22614004 However, recent research suggests that DCA has various off targets less known that lead to reduction of oxygen consumption in mithocondria https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6562462/
      So overall, even if DCA is somehow a little in between from the point of view of the strategy discussed here, I think it could be a relevant addition to this strategy if there is more space to add capsules. There are studies indicating that DCA works well with most of the drugs discussed here, such as Metformin (Ref.)
      Also, I must say that the drugs and supplements mention above to address the “Shut Down Energy Engine” strategy are those that I selected from a longer list of fermentation and mitochondria inhibitors
      https://www.cancertreatmentsresearch.com/drugs-and-supplements-that-block-fermentation-and-help-fight-cancer/
      https://www.cancertreatmentsresearch.com/a-list-of-mitochondria-inhibitors/
      In those lists, there are other drugs and supplements that can be very relevant.
      DCA is also mentioned in those lists.

      Kind regards,
      Daniel

  13. From what I understand some types of cancer cells (e.g., localized prostate cancer) do not ferment glucose. What would you recommend for these patients? Thanks

  14. Dan, you say “3. Syrosingopine: 2mg/day” above. Would this 2 mg a day dose be enough for a syrosingopine plus metformin anti-cancer therapy? If so, did you figure it out or did you find it somewhere?

    1. Dear GgE,

      Thank you for the question. There is no human study to indicate the effective dose of Syrosingopine against cancer. This is why, like typically done in clinical trials, the best we can do is to consider the known safe dose and start from there. 2mg/day is a known safe dose. We can always consider escalating the dose step by step while making sure the steps are done in a safe manner having an eye on potential side effects. Alternatively, we can stay with the known safe dose of 2mg/day and rely on the other drugs and supplements inside the strategy to work together with Syrosingopine and help achieve the purpose.

      Kind regards,
      Daniel

  15. Daniel, So I am trying to block pathways for ER+ HER2- Breast Cancer…mets to Hip, Sacrum and liver. I am on oral Chemo Xeloda…its 1 week on 1 week off how would I use things with that? I am on Propranolol, Metformin 500mg 1 x a day, 500 mg Berberine 1 x a day, 20mg Metformin, Lovastatin 1 x a day, 2000 IU Vitd3, K2, Magnesium Malamate, Magnesium Citrate, Low Dose Baby Asprin. I have a script for Doxycycline and for Mebendazole (both I haven’t started yet because I am not sure how to take with the oral chemo) Also I got a script for 25mg Diprydamole 4 x a day but I was told not to take that with the propranolol so not sure when and how to take that? Any recommendations?
    Thanks,
    Nicole

    1. Dear Nicole,

      This is what I would consider:

      1. I would use Propranolol continuously
      2. I would increase Metformin if possible to 1g/day or at least 750mg/day and take it until a few days (e.g. 3 days) before each cycle of Xeloda when I would stop it. After starting Xeloda I would restart Metformin, the same day. So I would end up using about 11 days Metformin out of the 14 days of ON/OF Xeloda cycle. The point of stopping Metformin 3 days before Xeloda is to give chance to the tumor cells to “weak-up” and be better targeted by Xeloda. The point of using Metformin starting with day one of Xeloda is to help Xeloda do a better job.
      3. For Berberine 500mg/day, I would follow the same schedule as with Metformin. If not possible to increase Metformin dose, I would increase Berberine from 500mg to 1000mg/day
      4. 20mg Lovastatin/day is very little in my view. I would change it to Atorvastatin due to reasons discussed here https://www.cancertreatmentsresearch.com/cholesterol-lowering-statin-drugs-to-fight-cancer/ and I would consider 40mg to 80mg as used in COC protocol
      5. Vit D3 2000ui/day – I would use higher dose
      6. Magnesium is good but I would use Magnesium gluconate if possible
      7. Low dose aspirin I would keep continuously
      8. Mebendazole I would just take continuously at a dose of min 200mg/day with fatty food https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/
      9. There is a minor chance for interaction between Propranolol and Dipyridamole https://reference.medscape.com/drug-interactionchecker?src=google If I would want to add Dipy, I would just start with a low dose and increase step by step towards the target dose as long as there are no side effects
      10. Besides the above, I would consider
      – some stronger fermentation inhibitors such as discussed above. The easiest to implement would be Quercetin, EGCG and Omega 3. Actually, Omega 3 I would consider anyway in breast cancer as wel ass in combo with chemo. I would implement as discussed in the article above.
      – in hormonal cancer such as breast cancer, I would consider adding a few more supplement/drugs the following strategy https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/ I would specifically consider adding HCA and maybe Bergamot

      I hope this helps.

      Kind regards,
      Daniel

  16. Daniel, Thank you for your reply…I am sorry…I am not clear about the Metformin?? I can tell you that I hesitate to take more berberine because I find it consitpating.

    I read the article you linked about the Statins…I don’t see how lovastatin is bad and really I am doing soo well on it and I do not think I can get my doctor to prescribe a different kind because she didn’t even want to prescribe that because I do not have high cholesterol …so….Should I take it twice a day instead or do you think it won’t even work?? The article you linked shows it to be good for blocking cancer…. Also the article you linked says that Lovastatin should be taken with food…I didn’t know that …I was taking it at bedtime because that’s what it says on the bottle…should I switch that to Morning?

    About the propranolol…you are saying its ok to take it with dipyridamole??? I heard no because it lowers heart beats per minute. I was originally taking 40mg of the propranolol but my beats per minute dropped to low so I have to cut the pill in 1/2 and 20 mg morning and 20mg evening… isn’t it going to drop again with adding in the dipridamole???

    Reference the Vit D3 when I go any higher than 2000IU a day it bothers my bladder really bad…I have interstitial cystitis…

    I have an Omega 3 but was worried it could prevent my sprecific Chemo from working? Also I want to take Quercitin…any recommendation and time of day and dosage? I cannot get it IV.

    I wanted to also let you know I have Epstien Barr Virus and HSV as well.

    1. Dear Nicole,

      I am speaking theoretically about what I think is the best. Sometimes, these ideas can not be applied due to various reasons. Berberine inducing constipation in your case is such an example.

      Lovastatin is good (I did not said is bad) but as discussed in the article there are others that may be even better due to their pharmacokinetics. Atorvastatin stays longer in the blood and it may penetrate tissue better. This is also one of the reason why COC protocol is suggesting this one. But again Lovastatin is also a good one.

      If I would have one pill only, I would take it at night. If there are more pills to take/day, I would spread them during the day to try to keep a more constant level in the blood.

      If you already so that you experinece side effects from combining Propa with Dypiridamole, please avoid combining them again. My point is that I would combine such drugs only if I would not experience side effects.

      The same applies for Vitamin D3. If higer dose are nos suitable for you, lower to what makes you feel good or remove totally. The first priority is your well being. We have many options for supplements and drugs that can help. No need to force one that makes you feel side effects.

      Based on science, Omega 3 is expected to support chemo https://www.cancertreatmentsresearch.com/omega-3/ However, if you do not feel that is suitable please disregard my idea.

      The post above addressed the proposed dose for Quercetin in my view, but that may be too high for you. You may want to try a lower dose.

      Kind regards,
      Daniel

  17. Daniel, Thank you for taking the time to reply to me again 🙂 So KIND and I greatly appreciate it.
    1 more question…you said you would take the Mebedazole continuously do you mean 1 month on 1 off to rotate with Doxy or just take the Mebedazole continuously for months at a time?

    1. Daniel, I should have mentioned I take berberine for 4 weeks then 2 weeks off because they say you cannot or should not take it continuously?? Am I correct that you say I should take it the same as I take metformin…which would now be 5 days on 2 days off (according to your advice above)?

      1. Do I keep taking the Metformin when I am on the off week of chemo? So in other words I would take it 7 days a week on the off week and when I start chemo I would not take it on the Saturday and Sunday before Monday Chemo and start taking it again with the chemo on Monday? Am I making sense? ha ha?

    2. I would just take Mebendazole continuously without interruption if there is no side effect. If after a few months there is no response, I would stop. If there is response, I would keep it on for life. (why: the case report I discussed in my post on Mebendazole – responding to Mebendazole, and once stopped tumor came back)

      Kind regards,
      Daniel

  18. Dear Daniel and all,

    As for syrosingopine,
    1. Is it still manufactured/ available as a drug? Any known reliable sources?
    2. I couldn’t find info if it is expected to pass blood-brain barrier?
    3. What are the expected/ experienced results of 2mg/day due to lowering blood pressure, if patient is regularly having normal pressure?

    Many thanks for any info!

    Kind regards,
    Nissim

    1. Dear Nissim,

      1. Info is addressed in this thread https://www.cancertreatmentsresearch.com/community/metabolic-inhibitors/combo-metformin-and-syrosingopine-looks-awesome/paged/16/#post-2114
      2. The only relevant literature available is on pharmacokinetics is on the parent drug reserpine. According to the scientists involved in studying the drug, there is no reason to think that syrosingopine will be different. So please check Reserpine (I would do it but I have no time now) and please let us know your findings
      3. This point was addressed by the contributors at the link above (the tread on Syrosingopine)

      Kind regards,
      Daniel

        1. Hi Nissim,

          Reserpine if it seems to go through BBB:
          “Reserpine is a sympatholytic agent that acts at the presynaptic nerve terminal of postganglionic adrenergic neurons to cause a depletion of norepinephrine. … Reserpine also crosses the blood-brain barrier, where it causes the brain neurons to become depleted of serotonin, dopamine, and norepinephrine. ”
          Sirosingopine is a derivative of reserpine but I am not sure if it meets the same lipophilic qualities. I’m going to look at it because it can be an addition to my therapies

          1. Dear Manuel,

            Thank you for this, I also try to get more information on syrosingopine (+metformin).

            Let’s keep updating if there’s new info.
            Good luck!

            Kind regards,
            Nissim

  19. Manuone said:
    “Reserpine seems to go through BBB: “Reserpine is a sympatholytic agent that acts at the presynaptic nerve terminal of postganglionic adrenergic neurons to cause a depletion of norepinephrine. … Reserpine also crosses the blood-brain barrier, where it causes the brain neurons to become depleted of serotonin, dopamine, and norepinephrine. ” Sirosingopine is a derivative of reserpine but I am not sure if it meets the same lipophilic qualities.”

    Based on what I read I don’t yet know if syro goes through the BBB. I assume that it does but it has different and much more reduced effects than reserpine in the depletion of brain and CNS catecholamines. This is supposed to be one of the reasons why reserpine used to cause marked sedation, serious depression and nightmares and many other strong brain-related side effects which were much less pronounced with syro. And this is why reserpine was replaced by syro.

    For some unknown reason I cannot attach files here. So I copy some excerpts:
    “Reserpine was the most potent, rescinnamine the next and syrosingopine the weakest in the depleting effects on brain amines of rauwolfia alkaloids. After syrosingopine, brain dopamine (DA) was decreased to a smaller degree and with a shorter duration as compared with norepinephrine (NE) and serotonin (5-HT), whereas reserpine elicited a marked and long lasting reduction in these amines. Accordingly, syrosingopine induced a depletion of brain NE and 5-HT without alteration in brain DA content 2-4 days after administration. Repeated administrations of syrosingopine, 2 mg/kg daily for 2 or 4 days, resulted in similar alterations in brain amine levels. This selective depleting effect of syrosingopine on brain amines was potentiated by combined treatment with disulfiram or fusaric acid, a dopamine β-hydroxylase inhibitor. Under the condition of selective depletion of brain amines induced by repeated administrations of syrosingopine, 2 mg/kg daily for 2 days, the analgesic action of morphine was not affected, whereas reserpine and tetrabenazine antagonized morphine analgesia, concomitant with inducing a depletion of all brain amines.” From Pharmacology Biochemistry & Behavior, Vol. 4, pp. 419-425. Copyright © 1976 by ANKHO International Inc. Selective Depleting Effect of Syrosingopine on Brain Catecholamine Levels with Relation to Morphine Analgesia in the Rat. T. FURUKAWA 1 , T. SANO, Y. KOHNO, M. KOGA AND N. NAGASAKI. Department of Pharmacology, Kurume University School of Medicine, Kurume, Japan. (Received 24 June 1975)
    And:
    “catecholamines released by reserpine are chiefly inactivated by intraneuronal monoamine oxidase . Likewise, catecholamines liberated by syrosingopine may be mostly metabolized in sympathetic neurons in the same way and partly inactivated extraneuronally by catechol-0-methyl transferase (COMT).”
    “Syrosingopine (carbethoxysyrosingoyl reserpate) has been reported to release peripheral catecholamines without appreciably depleting brain amines over a wide dosage range.” From Life Sciences Yol . 5, pp. 1503-1508, 1966 . Pergamon Press Ltd. Printed in Great Britain. THE EFFECT OF SYROSINGOPINE ON SPONTANEOUS EEG AND EEG AROUSAL INDUCED BY EXTERNAL STIMULI IN RABBITS. Y. Takeo, G. R. Pscheidt and H. E. Himwich, Galesburg State Research Hospital, Galesburg, Illinois – 61401
    Cited from F.B.H. Orlans, K.F. Finger and B.B. Brodie, J.Pharmacol . 128, 131 (1960).

    But actually this discussion should go in the syrosingopine pages rather than here.

    1. GgE thanks for the info
      Yes, I think we should move this discussion in the sirosingopina section …
      I am also not clear about the penetration of sirosingopin in BBB …
      On the other hand I would worry about sedation in a patient with a brain tumor that is already quite sleepy.

      Kind regards

      1. Manuone said “I would worry about sedation in a patient with a brain tumor that is already quite sleepy.”
        I would worry too. But if this is the best (or the only) therapy left to fight brain mets or glio, then sleepy is better than nothing.
        On the other hand, syrosingopine is not very sedating by itself, unlike its mother molecule the reserpine. As far as I understand, much of syro’s mild sedating effect doesn’t come from its action on the CNS but from its blood pressure lowering effect instead. And this is easily countered by a cup of coffee or tea, or just plain old caffeine pills like those that students use to prepare for final tests. This should not hurt most people unless their cardiovascular system cannot tolerate it. After all, caffeine 1- has some mild anti-cancer effects by itself; 2- strengthens the immune system; and 3- enhances metformin anti-cancer action in some cancer types.

        https://www.medicalnewstoday.com/articles/319510.php

        https://WWW.CANCERTREATMENTSRESEARCH.COM/HOW-CAFFEINE-MAKES-CHEMO-RADIO-IMMUNOTHERAPY-MORE-EFFECTIVE/

        European Review for Medical and Pharmacological Sciences 2018; 22: 2461-2467 D.J. POPOVIĆ1, D. LALOŠEVIĆ1, D. MILJKOVIĆ1, K.J. POPOVIĆ2, I. ČAPO1, J.K. POPOVIĆ3 Caffeine induces metformin anticancer effect on fibrosarcoma in hamsters

  20. Daniel, you mentioned I should take the menbedazole continuously but you said 200mg per day?? That prescription is usually for 100mg per day was that a typo or do you really mean 200mg per day…because I know the COC only says 100mg a day.?

  21. Hi everyone,

    I am a newcomer to this site and I am very confused about what I should do. I have recently been diagnosed with both LGL leukemia (very rare) and myelodysplastic syndrome (which in about 40% of cases develops into acute myeloid leukemia, or else kills my massive infection or uncontrollable bleeding). My doctor wants to put me on once weekly methotrexate for the LGLL ignore everything else for now. So far I have done nothing except purchase some fenbendazole.

    LGL leukemia is a cancer of the cytotoxic T cells. Myelodysplastic syndrome is caused by some defect or mutation in the progenitor cells of the bone marrow, causing, in my case low red and white blood cell counts. My neutrophils are hovering just above danger level.

    Does anyone have any experience with any of this? I read that I should probably inhibit the JAK/Stat pathway, but the supplements that do his increase NRF2, which is often overexpressed anyway in myelodysplastic syndrome and other forms of cancer.

    And where can you get dipyridamole, if your doctor won’t prescribe it? Or a statin, when your cholesterol levels do not indicate that you could benefit from one?

    I live in Ohio, US, and my doctor works at, and for, a prestigious (and self promoting) medical institution. He has patients scheduled every twenty minutes for months ahead. I like him personally, but he simply doesn’t have the time I would like to have with him to discus options. And he is totally bound by protocol. I do do not believe he is free to step outside the box.

    Any help would be much appreciated.

    Joany

    1. Hi Joany,

      The ideal always would be to have on our side a doctor who collaborates with us or at least willing to “listen”, unfortunately this does not usually happen. Maybe you can order medications from India or websites like buy-pharma.
      Try to build a therapy step by step. This latest article “the house of power of cancer” and “summary of the website” can give you an idea about the different options.

      kind regards

  22. Hi – Thank you for such a stellar site! I’ve found this to be one of my top cancer go-to websites. I am very interested in your proxidant/antioxidant strategy as I’ve recently started chemotherapy for recurrent, grade 3, stage 3 undifferentiated pleomorphic sarcoma. I’d like to do everything possible to ensure chemo effectiveness. I love how you laid out the strategy of shutting down the energy source. Do you have the same for pro-oxidant?

    Julia

    1. Dear Julia,

      Thank you so much for the kind and motivating words! I will do my best to work on that asap. It’s just that I am working on too many things at the same time. However here are a few notes from me:
      – From the pro-oxidant strategy point of view, one of the key re-purposed drugs to support chemo is Auranofin in my view.
      – Next to that, from a drug resistance point of view, there are various aspects that could be considered. Here are some of the major ones I discussed many years ago https://www.cancertreatmentsresearch.com/if-chemotheraphy/
      – Because of this reason https://www.cancertreatmentsresearch.com/if-chemotheraphy/ I would also consider using Ketorolac prior to chemo, if possible
      – Because of reasons discussed here https://www.cancertreatmentsresearch.com/tips-on-treatments-a-list-to-be-constantly-updated/ I would stop ferementation inhibitors including Metformin (which indirectly impacts also fermentation) a few days prior to chemo and restart during the chemo day

      Kind regards,
      Daniel

  23. Thanks for the quick reply! I’ve been digging in since receiving your reply. Good stuff! Quick clarifier:

    1) are you considering high dose IV Vit C and antioxidant or a pro-oxidant? I stopped IVC a week before chemo and was considering taking it up on my off weeks. Your comment about highs dose antioxidants has me rethinking, but I’ve always considered it a pro-oxidant.

    2) curcumin? Is that a antioxidant worth avoiding during chemo weeks?

    3) HOCATT machines – I haven’t been feeling well since chemo started. Was looking into this as a way to sweat and get oxygen to cells. Quick reaction?

    Thanks!!

    1. Dear Julia,

      1. In my view, based on the scientific literature, high dose Vit C is pro-oxidant. Because it inhibits fermentation I would stop it a few days before chemo. I would restarted a few days after.
      The major anti-oxidants I would avoid combining with chemo are Alpha Lipoic Acid, NAC, Glutathione. I would also avoid a few others like Vit E during this time.

      2. Curcumin is not something to avoid during chemo, in my view. I would just not take it a few days after chemo (2-3 days). Curcumin has various anti-cancer effects, some pro-oxidant too, so I see it as part of the plant extracts that are suitable with chemo, Beyond my view, cancer clinics in Germany are using it in combo with chemo and sometimes with successful results.

      3. HOCATT – I do not know the machine. But during chemo or radio it would help to get oxygen to the cells.

      Kind regards,
      Daniel

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