Visitor Comment: Remission after starting TM (Tetrathiomolybdate)

Today, I received a new comment on an article I wrote sometimes ago on Tetrathiomolybdate: https://www.cancertreatmentsresearch.com/?p=249

I find the comment so relevant that I am going to publish it here, to increase its visibility:

My girlfriend started taking TM in late 2001 after her oncologist threatened to cut her off if she didn’t have mastectomies and a hysterectomy. She had several lumpectomies, cervical surgery and one ovary removed at that point, spread out from age 19 to age 30. I connected her with nurse Jan at the University of Michigan that was dispensing TM to the group of 30 + people with advanced cancer, and she benevolently supplied us with contact information of the supplier and the Tennessee pharmacist that made the caps and aided in communication between the staff at U of M, and my girlfriend’s doctor. The cancer was in remission for 3 months at which time we broke up. She maintained low copper levels for 6 more months with no evidence of cancer. However, she lapsed from taking the TM after losing her job. As related to me anecdotally, the cancer returned immediately and she needed to have lymph nodes removed. As an ex-boyfriend of a newly married woman I didn’t feel it was my place to grill her about the particulars. As I understand it, she has maintained treatment with TM ever since, and has had no additional cancer related events. Of note, she was able to become pregnant with her remaining ovary and now has a 10+ year old daughter. It was communicated to me that lapsing from taking the drug results in high spiking of copper levels; higher than before treatment began.

The rumor is it that University of Michigan licensed the drug to a group of doctor investors in California that put together an application to get TM approved for use in humans by the FDA. However, the application was botched and after great expense and time, the application was rejected for unknown, although allegedly frivolous reasons. Subsequently, the doctors fought, pointed fingers and lost interest in investing additional monies in the drug.

It has also been suggested that TM would be too readily available as a knock-off since it is just a metal salt. Ease of purchase without going through the doctor-prescription system would deprive the California doctors of their investment money. In 2000, after reading a WIRED magazine article on TM I found pricing for a 55 gallon drum of powdered industrial TM at around $300.

My personal opinion is that the drug is wildly effective for cancers that present tumors needing to be supplied with blood vessels in order to grow the tumor rapidly. TM’s cost is low, side effects are minimal and it may be used in parallel with other treatments without affecting them.

The downsides are:
-It takes a few weeks time to reduce copper levels to a level that stops the cancer from being able to construct a blood supply network.
-You can’t stop once you start or it’s thought that the cancer will come back with a vengeance.
-You might have to get back to work.

by David S

Thank you David for this valuable piece of information!

I only have one comment to the above, i.e. there is another downside and that is related to the fact that following Tetrathiomolybdate administration, patients can get sulfur burps that smell/taste like rotten eggs. This may be reduced or eliminated using concomitant administration of proton pump inhibitors such as Omeprazole. To me, this side effect is so irrelevant that I would go forward with Tetrathiomolybdate.

If you like to read the article on Tetrathiomolybdate, please click on the following link https://www.cancertreatmentsresearch.com/?p=249

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

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Emad
Member
Emad

OK but are you guys sure that there will be no developing of resistant to Tetrathiomolybdate ???
for treating cancer in my opinion the hardest thing to do is not dealing with the side effects !!!
its the resistant to these treatments that is very hard to deal with .
even a powerful drug like Salinomycin will not be effective after using it for a while
and the same thing is happening with the immunotherapy drugs
I’m always looking for those kind of treatments that cancer cannot develop any resistant to it once it works
———-
and by the way , what is this ?
http://www.huffingtonpost.com/entry/promising-therapy-sends-93-percent-of-incurable-cancer-into-remission_us_56c3cbf5e4b0c3c550531fe5

Emad
Member
Emad

I read about Salinomycin becoming weak from here :
to be honest , I hope its not true
http://www.hindawi.com/journals/bmri/2012/950658/
read 7.2. Case  2 82-Year-Old Female Patient with Advanced and Metastatic (Pelvic Lymphatic Metastasis) Squamous Cell Carcinoma of the Vulva
about tetrathiomolybdate , it will be excellent if its hard for cancer to develop any resistant to it , I will try it with my mother as soon as I can

ovidiu
Member

Tetrathiomolybdate appears to be most effective against micrometastases, and sometimes ineffective against large tumors. So it might be used best as a maintenance therapy, or between chemotherapy cycles, if the blood formula has degraded badly and the patient needs time to recover.
Many anti-angiogenic drugs induce HIF-1a, which leads to increased stemness, but Tetrathiomolybdate degrades HIF-1a, also decreases invasiveness and promotes anoikis.
Tetrathiomolybdate inhibits mitochondrial complex IV and mediates degradation of hypoxia-inducible factor-1α in cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/26469226
Tetrathiomolybdate inhibits head and neck cancer metastasis by decreasing tumor cell motility, invasiveness and by promoting tumor cell anoikis.
http://www.ncbi.nlm.nih.gov/pubmed/20682068
Copper chelation leads to upregulation of glycolysis by cancer cells, so pairing a copper chelator with an inhibitor of glycolysis looks promising (a proton pump inhibitor, like omeprazole, could help).
Bioavailable copper modulates oxidative phosphorylation and growth of tumors.
http://www.ncbi.nlm.nih.gov/pubmed/24218578

Emad
Member
Emad

OK Daniel , here :
Figure 4
http://www.hindawi.com/journals/bmri/2012/950658/fig4/
administration of both erlotinib + Salinomycin led to a significant tumor regression , huge decrease of the tumor markers
then after 3 months (with no treatments) the tumor grow back again , and the patient decided to take salinomycin only
but with Salinomycin alone , there was no more tumor shrinkage , only disease stabilization for 4 months
you can see it on the diagram , the tumor markers are raising slowly
isn’t that what’s always happening when there is a disease stabilization ? it’s a matter of time until the tumor wins and grows back again
I hope I’m wrong , I hate to see Salinomycin loosing a battle , but we should have a strategy in case salinomycin stops working
maybe 3BP is the best choice to boost the effect of Salinomycin , just like the SCLC patient who achieved a complete remission in 4 weeks

ovidiu
Member

Both erlotinib and salinomycin are metabolized by CYP3A4, so co-administration may slightly increase the AUC for salinomycin.
But salinomycin is most effective against cancer stem-like cells, like the ones who have undergone EMT, and less effective against those with epithelial markers. On the other hand, erlotinib is not effective against cells that have undergone EMT, actually it favors EMT (a problem after 1-2 months of exposure), so there’s no surprise there’s synergy between erlotinib and salinomycin.
PS. Sorry for the off topic.

Emad
Member
Emad

like Ovidiu said , sorry for the off topic

I think TM should always be included in our anti cancer cocktail

the sulfur burps are not an issue , its still better than dying in my opinion

the little problem is the decrease in blood counts , maybe it will be a big problem if the WBCs fall nearly below the normal range, its not good al all even for a healthy person not just cancer patient

combining chemo with TM may increase the chance of this side effect ?

anyway , i can’t wait to get TM , i need it

Emad
Member
Emad

I put a comment about TM but I can’t find it ?

Alex
Member

Dear Emad.
I would like to know your feedback on TM.
Let us know,
Best wishes,
Alex

Emad
Member
Emad

I didn’t use it with my mom

it can cause some drop on blood counts which is already a side effect of chemo , if my mother is not on chemo then most likely I will end up using it for sure as I believe it could really help

but I don’t know which is better as anti angiogenesis , TM or Thalidomide !??