Prostate Cancer

157 thoughts on “Prostate Cancer”

1. D, here are some other good ones.

   PMSA
   https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5355374/

   and next generation
   https://www.ncbi.nlm.nih.gov/pubmed/28102507

   (Apatone) vitamin C and K3
   http://www.medsci.org/v05p0062.htm

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   1. Thanks J. I included Vit C + K3 + E for awareness. Do you know anything about the accessibility of PMSA?

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      1. D, the radiotherapies in prostate seem to be moving quickly in clinical trials.
         Sometimes high quality cancer treatments can linger for decades without any forward progress,
         yet Lu-177 appears too good to stop.

         https://clinicaltrials.gov/ct2/show/NCT03042312?term=Lu177-PSMA-617&rank=1

         Oops! Missed the mention of C+ K3 +E.
         What do you think of this one?
         https://www.ncbi.nlm.nih.gov/pubmed/22584645

         This one seems much better than K3, though they do not even have a mouse study.
         This is another off the shelf compound with a bromine substituted in.
         Yet, after all of these years it is still not clear whether it could be helpful or very dangerous.

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         1. Hi J, this is interesting but not accessible. In general, I am looking at what is both interesting/potentially relevant and accessible. However, we should keep in mind those with high potential and not accessible for the moment when we can also support somehow financially thee advancement of research and testing. Maybe I should start up a post where all of us could do a brainstorming on ways to develop a successful framework that can attract world wide financial support, to identify and support development/testing of those treatment techniques with high potential but not financially interesting for the industry. I think this world already has enough knowledge, technology and capable people to find a solution to cancer. Just that the current framework intended to address that is wrong. When I look at what happens to the cryptocurrencies, I realize the world is ready to change to new frameworks. We just need to find the right one for the medical world. What do you think?

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            1. Yes, D, after all of these years it is still as frustrating as ever that a true revolution in cancer treatment from the grassroots as not happened. It does not make sense! 20,000 people per day die of cancer. I was thinking recently that if people were to simply take a dose of 3-BP just before cancer claimed them, then it would be immediately clear that 3-BP is helpful for some patients. How has 3-BP been allowed to be endlessly delayed for the people who medicine has disowned? Why has euthanasia been allowed to be seen as a more palatable choice than actually trying things such as 3-BP? Cancer treatment now would be greatly more effective if people at imminent risk of cancer mortality were given the opportunity to more fully choose their treatment.

               For some reason, those people who have advanced very bad logic to oppose 3-BP have won.
               The idea that 3-BP is too dangerous a drug to treat someone is at imminent risk of death from cancer is not rational.
               3-BP is not more dangerous than the risk posed from the last moments of terminal cancer.

               In the new age of the internet and leveraging of people power, why haven’t good ideas won?
               It does not take that much research to realize that effective cancer are now clearly approaching.
               Metastatic cancer was cured over 30 years ago in lab models.
               How much longer for people?

               It is also a good point to try and stay with treatments that can be of use to people right now.
               One thing that we could do on the forum is to give 30 day treatment suggestions.
               For example, with vitamin C treatment: one could cycle through a range of combos for a week or two
               to see which one might be of especial usefulness. As it is people now probably stick with one
               treatment protocol even if it is not particularly effective. By rotating through say, Vitamin K3,
               alpha lipoic acid, phenylascorbate, doxycycline, etc. one could look for the weak point.

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               1. dear Jcancom,

                  i totally agree. I think it is not just because of the way companies work – it is also because of the way people think. About authority. Most people believe 100% of what they hear from their doctors. And these doctors are not always open minded (the doc of Ergin’s mother is not the norm but the exception).

                  I can assure you that most oncologists in Central Europe have not even heard about 3-bp, metabolic treatment or even about re-purposed drugs. Or if they did they simply dont care as those are not part of the paradigm.

                  And cancer patients dont question their authority.

                  Of course this is rooted in the fact that many people are selling false hope with lies and senseless methods.

               2. Hi J,

                  I think the answer to most of your points is: wrong focus or fragmented focus.

                  Wrong focus: most of the pharma companies, full of well intended people, can search for cancer solutions as long as there is someone who is investing his money in that. Those investing money (btw many of which are former, current or future cancer patients) need more money back – otherwise they will better keep them in a bank or invest them is e.g. construction, consumer goods or whatever. The pharma needs to deliver back to the investor while doing their best to help people. But that fundamentally limits their search and potential outcome. The search and approval of the outcome is extremely expensive so the result is an expensive solution with limited effectiveness. The point is that almost everyone in pharma industry has the best intentions but because of the framework, the results are of very small benefit for humans.

                  Fragmented focus: there are a lot of grassroots and foundations trying to do something good. But they do not work together. Everyone has own little goal with own little investment. In other words CHAOS. A lot of positive energy defocused. Imagine what you could do with all this energy if you could focus it on the right subjects. What is wright we may not know, but if we would focus on some high priority subject we may quickly come to great results.

                  The world is full of people who would like to do something good in oncology and contribute. But the KEY questions is what kind of framework we can put in place to capture all this energy and focus? That would be like collecting the light from many bulbs and build a laser out of it.

                  I feel that a block chain like project may be the answer here. I am trying to understand that technology better and how we could use that to achieve the above.

                  This project I recently came across may help us to get some ideas: https://bowheadhealth.com/
                  What do you think? (this is a question for all the friends reading this, off course)

                  Kind regards,
                  Daniel

2. Very interesting as always. I am sure many people will find this helpful!

   Clorgyline – antidepressant, may be helpful against bone mets:
   http://www.medicalnewstoday.com/articles/316337.php

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   1. Thanks Carl. I will have a look at Clorgyline. As the summer ends I will restart my research activities.

      These days I am specifically triggered by the role of viruses in triggering and maintaining cancer. I see too many cases in which someone next to a cancer patient (genetically related) may relatively soon develop cancer as well. I know this may also be related to mind (e.g. new germanic medicine) but I suspect that is related to a combination of virus + genetic profile.

      What is interesting is to see that most of the anticancer drugs we are discussing have also known anti viral action.

      Kind regards,
      Daniel

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      1. Hell Daniel,

         I think it is also related to grief. it makes the immune system weaker. Of course, this does not mean that the virus connection is false. As you surely know about HPV…. By the way – you could look at the cancer incidence among people with AIDS as part of your research.

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         1. Hi W,
            Thanks. I find it a strange coincidence to see that (based on the limited information I have) it happens more often to the family members with the same genetic line. I totally agree that grief plays a role. It also well known that some cancers have a virus as trigger. But my point is that it may be bigger than just some cancers. It may be most. What if the genetic profile makes you more vulnerable to some known and/or unknown viruses. And when the grief and/or life is reducing the immune system effectiveness and changing other balances in the body could just support the initiations of what we call tumors. It is like planting a seed (virus) in the right ground (weak body due to grief etc.). I know it sounds simple, but if this is the case, there may be huge value in focusing the treatments on well knwon mechanisms in viruses. And that is interesting because for example virus activity strong depends on pH and proton pump inhibitors may strongly influence that (as we know same happens in cancer cells). Same with ion dynamic which is extremely important for viruses (and as we know for tumor cells). And so on.
            I am not saying that this is it. I am saying that this may be a perspective that could go deep towards the origin of cancer. That in turn may lead to more effective treatment strategies. Anyway, I will do a deep dive on this perspective asap.

            I hope you are doing well W.

            Kind regards,
            Daniel

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3. Hi Daniel,
   Thank your for writing a new post about prostate cancer. Yesterday I was at a psychology course about healing and there I spoke with a man who had prostate cancer stage 4 grade 4, who is now cured, even though it is considered at this grade incurable. He based his healing on the faith in God and some energy that God gives you. He goes to the monastery regularly and brings people there, does a lot of good deeds, is helping people and he changed his lifestyle.
   I wish everyone coming here on the site health and to remember that the psychological and spiritual transformation is also important when trying to heal.
   Kind regards,
   Anca

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   1. HI Anca,

      Thank you for sharing. I very much believe that. Humanity understands very little about how human body works and actually how everything works, while doing its best to evolve that. Unfortunately, in the quest of learning and evolving, we are doing to little at understanding the spiritually and focus most of our efforts on understanding physical mechanism. I think the ultimate healing, and evolution, can come from the spiritual path. But that takes time for many of us as it requires changes of own paradigms. And when fighting cancer time is essential. This is why I believe that a short term focus on drugs and supplements to gain time, and a long term focus on spirituality is best combination for a cancer patient, while working on both at the same time.

      Kind regards,
      Daniel

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      1. Hey Daniel.
         It’s great to see you keeping busy.
         I must say i admire your energy.
         Our warm thoughts go with you and our friends and family here.
         Always thankful.
         Please take care,

         Alex

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         1. Hi Alex,
            Nice to hear from you! All the best to you and your dear mom!
            Kind regards,
            Daniel

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      2. “Come healing of the spirit, come healing of the limb” – Leonard Cohen

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4. Hi Daniel,

   Very interesting piece!
   I have reviewed the role of metformine also recently. The evidence for metformine as anti cancer agent is really strong! But thus far only tested found in diabetics, so there is a caveat.
   A doctor is now looking into K3 and cancer for me, as our product is up for review. I keep you updated.

   Regards,
   Joris

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   1. Hi Joris,

      Thank you! Yes, Metformin is a big one for most of the cancers. I am curious to learn more about your K3 product – please keep us up to date!

      Kind regards,
      Daniel

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      1. Well, nothing you didn’t discover already for prostate cancer. There is also evidence for buccal cancers (Krisnamurthi S et al;Radiology 1971 May; 99(2):409-15; PMID 55535581), where K3 improves the effectiveness of radiotherapy, and for liver cancer (High dose vitamin K3 infusion in advanced hepatocellular carcinoma. Sarin SK, Kumar M, Garg S, Hissar S, Pandey C, Sharma BC. J Gastroenterol Hepatol. 2006 Sep;21(9):1478-82.). In both cases they applied high doses K3 monotherapy.

         Kind regards,
         Joris

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5. Hi Daniel,

   I know from you that Metformin is really good in most cancers, but now my mother has such a bad taste in the mouth when taking any drugs (except minerals and vitamins and Melatonin and plants extract) and she says she feels something very chemical in her mouth after taking Metformin. What is your opinion on that? Should she take it, no matter what she feels afterwards? This is the effect of the chemotherapy, and especially Caelyx destroyed her, she could not eat or drink water after Caelyx first session, then she did another one even though Virgil said we should stop it, now my mother regrets doing the second dose of caelyx. Thanks to you we go at the clinic where we do Vitamin C and Vitamin B17 and Magnesium IV, and my mother can eat something and drink. She stopped chemotherapy a month and a half ago, and she also stopped all animal food then, she is eating wheat germs, and other germs with olive oil, rice , lentil and apricots or plums. That is all she can eat. She has diarrhea a lot, unfortunately because of the anxiety, we didn’t manage to eliminate all panic attacks or claustrofobia. One panic attack (from claustrofobia if she leaves the house to a darker and small place) has a harmful effect for a week. So the mental well-being is very important.
   I guess I am lucky that my mother is still alive, I see her walk in the garden and enjoying the fresh air. Faith is very important and staying outside the house. We will go to the oncholgyst Luca on 14th September, but we try to avoid all the harming things and the toxic stuff, because Caelyx was too much to handle and now a simple drug like Metformin is unbearable for my mother.
   May God help anyone with pancreatic and other types of cancer coming on the page!
   Thank you for writing everytthing so well documented, Daniel.

   Kind regards,
   Anca

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   1. Dear Anca,

      Thank you for your comment. Metformin is expected to slow down the activity. I think that if your mother feels/thinks that does’t help her and makes her feel less good, you may want to let her decide if she wants to stop. If that happens, I would consider replacing that with Berberine. This is a natural extract that is expect to have similar action as Metformin – btw, Metformin is also made of a natural extract (Ref.). Also, as a reminder, if the oncologist decides to start with a new round of chemo, is best to stop Metformin or any drug that slows down the tumors several days prior to chemo and restart those during the same day with chemo.
      I hope your mom will be better and better.

      All the best,
      Daniel

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      1. Dear Daniel,
         Thank you for your reply :). My mother will be happy to hear Metformin is made of a natural extract, and that there is also a similar drug (Berberine). I don’t think my mother trusts chemo any more, because she spoke with a lady from Targu-Jiu who has ovarian cancer, was very weak, she lost 20-30 kilos, and chemotherapy made her feel so bad, that is why the woman interrupted it 6 months ago, and she is better and stable now, only with vitamin C IV and Magnesium IV and Vitamin B17 IV and Potassium IV and a supplement form plants Hyper-Tum, that we find in Romania (it is antitumoral and it it stimulates the immune system, it contains more than 10 plants). That woman used Vitamin B17 every day for one month, then 3 times a week and now only one time a week (all these are costing her a lot of money, she pays 65 euro for one dose of Vitamin C and vitamin B17 IV, twice the money my mother pays for them, in Targu-Jiu these things are very expensive). The woman gained 6 kilos back, is feeling good, so my mother has hope now from that person (who was as bad as my mother, with diarrhea every day). It is always good to speak with people who went through this to give you hope.
         Thank you Daniel. I put you and your wife at the acatist in the monastery. I hope the workers did a great job for your wife’s funeral stone.

         Kind regards,
         Anca

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         1. Hi Anca,

            Thank you. The work on the monument is going too slow …
            You may want to read this comment, my response to that and the links within https://www.cancertreatmentsresearch.com/unlocking-zincs-potential-to-fight-cancer/comment-page-1/#comment-5656
            With a prescription from your doctor you should be able to order from the German pharmacy I linked in my post.

            Kind regards,
            Daniel

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6. Dear Daniel,
   Have you heard about a substance called equol? From the wikipedia article:
   Equol (4′,7-isoflavandiol) is an isoflavandiol metabolized from daidzein, a type of isoflavone found in soybeans and other plant sources, by bacterial flora in the intestines. While endogenous estrogenic hormones such as estradiol are steroids, equol is a nonsteroidal estrogen. However, only about 30% of people in the West have intestinal bacteria that make equol (file:///C:/Users/Ethan/Downloads/metabolites-05-00056-v2.pdf). Equol preferentially binds estrogen receptor beta.
   By binding to the estrogen receptor, equol may inhibit prostate cancer progression in tumors that have the ERG+ phenotype.
   Another aspect of its anti-cancer activity is its ability to bind to DHT. Equol may be one reason why men in China and Japan are said to have less prostate cancer. In these countries there is a large consumption of soy products. Also, a higher percentage of people in these countries have the gut flora to convert daidzein to equol.
   There is a simple urine test for equol production from soy (file:///C:/Users/Ethan/Downloads/metabolites-05-00056-v2.pdf). Unfortunately not literature is available about the role of equol in prostate cancer. It would be valuable to conduct a clinical trial to measure its effectiveness.

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   1. Dear Hasapiko,

      We had some intensive discussions here and almost missed your comment … thanks a lot for sharing that. I haven’t heard of Equol. I will check it asap as it sounds very interesting. I will let you know if I find anything else interesting about it. Please note that the links you shared are actually not web links but from your local computer. So they cannot be accessed. Whenever you find other interesting substances/treatments please let me know.

      Kind regards,
      Daniel

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7. D, here’s another reference for transilat.
   https://www.sciencedaily.com/releases/2010/11/101103171449.htm

   For prostate cancer:
   http://www.nature.com/oncsis/journal/v6/n5/full/oncsis201723a.html?foxtrotcallback=true

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   1. Small group of patients have these TRK mutations.
      They seem to do very well with this treatment.

      https://www.loxooncology.com/docs/presentations/Hyman_Larotrectinib_ASCO_2017_FINAL.PDF

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      1. Hi J, Thanks a lot! I will have a look at the other links tomorrow but I just saw LOXO’s results and are really impressive!

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         1. Yes, they do look very good and long lasting!
            The big drawback is that it seems that only 1% of patients have the mutations.

            D, there is some very impressive cancer treatments coming online lately.
            It is surprising how good Loxo is and yet it is still flying under the radar.

            Look at page 15 from the pdf for LOXO.
            Almost all the patients had ongoing responses if they first achieved a response withint the first 2 months.

            The company even has a second generation TRK, to help those like with Gleevec who progressed, though they have not needed to use to it because most patients respond so well.

            Also exciting that there are patients with a wide range of tumor types that are responders melanoma, breast …

            The company is ready to file a NDA over the next few months, so perhaps it will be available to patients soonish.
            Might be one to test for now, the company might allow expanded access.

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   2. Early pre-clinical research, though the drugs are already approved for other indications.
      Stopping metastasis would be such a good strategy.

      https://www.nature.com/articles/ncomms15584

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8. D, the numbers for Loxo look extremely impressive!
   There is an entirely new generation of very effective cancer treatments that are now emerging.
   We talked about the strategy of throwing a bunch of darts at the dart board until you hit a bullseye.

   Loxo101 is one dart.
   Cancer patients might have a 1% chance of having a TRK fusion, though if they did then LOXO could be such a blessing.
   If they did not have a TRK fusion, then time for another dart.

   Loxo is also developing LOXO-292 for RET rearrangements, LOXO-195 second generation TRK, LOXO-305 …

   LOXO-292 is early stage, yet it could be another dart.
   These fusion proteins seem like such a great point of attack against cancer.
   Why hadn’t they be targeted before? They are so abnormal that they make a perfect target.
   I checked the liver patient. He had a DNAJB1-PRKACA fusion. Wonder if anyone is in the process of developing something for them?

   “RET fusions have been identified in approximately 2% of non-small cell lung cancer, approximately 10-20% of papillary thyroid cancer, and a subset of colon and other cancers. RET point mutations account for approximately 60% of medullary thyroid cancer.

   RET gene fusions, much like TRK gene fusions, occur when the RET gene abnormally fuses to another gene. The hybrid gene that is created as a result drives tumor growth.

   Both RET fusion and select RET mutated cancers are primarily dependent on this single activated kinase for their proliferation and survival. This dependency, often referred to as “oncogene addiction,” renders such tumors highly susceptible to small molecule inhibitors targeting RET. LOXO-292 was designed to inhibit native RET signaling as well as anticipated acquired resistance mechanisms that could otherwise limit the activity of this therapeutic approach. LOXO-292 is currently being studied in a Phase 1 trial.”
   https://www.loxooncology.com/docs/presentations/2016_EORTC_LOXO-292_POSTER.pdf

   “Policy for Access to Investigational Agents

   Loxo Oncology is committed to helping patients who have not responded to available therapies and may benefit from its investigational therapies. Loxo Oncology’s Policy for Access to Investigational Agents describes the principles that the company will follow when considering a request, ”

   https://www.loxooncology.com/pipeline

   For LOXO101 consider the Duration of Response Figure on page 15.
   https://www.loxooncology.com/docs/presentations/Hyman_Larotrectinib_ASCO_2017_FINAL.PDF
   93% of responding patients remained on treatment.

   There were only a few non-responders ( for example, the patient eight from the top with the green band.
   In fact many of those who had not yet responded were still fairly early in the treatment course.
   (From what I read, patients who had very serious illness were included in the trial who traditionally would not
   be, because they wanted to treat all comers. At the bottom of the Figure, there are 6 patients who did not develop a response and went off-treatment after only 1 month. These probably are some of those seriously ill patients.

   The next page has median duration of response. The number of patients is small though the responses seem to stretch out for years. The Figure after shows 63% of the patients were progression free at two years. They did not even mention survival, though it must be very encouraging.

   If more patients had these TRK fusions, then we would have heard more about this treatment before. The NDA will be sent to the FDA within a few months. They moved this product through trials in only 2 years! When there is something this good the FDA will not stand in its way.

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   1. Hi J,

      Yes, I specifically enjoyed seeing slide 15. And indeed, it seems that after 1.8 months the patient knows if he/she is responding or not. The drawback is the 1% only respondents but the advantage is that those can be tests prior to the therapy for TRK fusion status that may be present regardless of cancer type.

      Here is a list of tests types and testing centers they suggest:

      • FoundationOne (Foundation Medicine)
      – 315 genes included + 28 genes for fusions
      • FoundationOne Heme (Foundation Medicine)
      – 405 genes included + 265 genes for fusions
      – Can be ordered for solid tumors, not just hematologic malignancies
      • MI Profile (Caris Life Sciences)
      – 592 genes included
      – Make sure that the Fusion Analysis is included
      • Solid Tumor FOCUS::ONCOMINE NGS Panel (Cancer Genetics)
      – Indicate on the order form to include fusions
      • Oncomine™ Focus Assay (Sirona Dx)
      – 52 genes, including 23 genes for fusions
      • SmartGenomics NGS Solid Tumor (PathGroup)
      – 62 genes, including fusions
      • Universal Fusion/Expression Profile (Neogenomics)
      – 1,385 genes, including fusions
      • GeneTrails Solid Tumor Fusion Gene Panel (Knight Diagnostic Laboratories)
      – 20 genes for fusions
      • OmniSeq Comprehensive (OmniSeq)
      – 144 genes, including fusions
      http://www.trktesting.com/HowToTest.pdf

      Kind regards,
      Daniel

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9. Exactly D!

   This is so critically important from the patient perspective.
   Knowing that you will probably respond within a 2 month window is very important information.
   If you have not responded in that window, then you could plan from there.
   Yet, even several of those who did not respond early, did respond later.
   It might be very difficult for cancer to work around an anti- fusion treatment

   Notice that most of the patients had yellow dots after at 2 months. Nearly all of those with a yellow dot
   than had these prolonged ongoing responses that stretch out to 2 years with this preliminary data.
   Only 3 of the patients with a yellow dot stopped responding, though this data is still early.

   So many cancer drugs give a response though it can many months to know if the patient is in the responder
   class and then the response itself might only be for a few months or even weeks.

   LOXO-101 apprears to be a true breakthrough product.
   The responses are early, and they typically are long lasting– into years.

   You are right about 1% being a disappointment, though there are these other fusions.
   For example, the liver patient and Fibrolamellar hepatocellular carcinoma.

   “A recent study showed the presence of the DNAJB1-PRKACA chimeric transcript (resulting from a 400kb somatic deletion on chromosome 19) in 100% of the FHCCs examined (15/15)[2] This gene fusion has been confirmed in a second study.” wiki

   From above, RET fusions appear in 2% of NSCLC and others.
   Fusions look like such a great target.
   You can attack the fusion, few side effects and the cancer finds it difficult to mutate around.

   Possibly the genetic approach really will work out.
   All you need to do is find all the escape routes that cancer has available and then close them off.

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10. D, fusion proteins are a very exciting avenue of cancer research!

    I do not believe people have been fully aware of how important a concept this is.
    Consider that an onco-fusion protein is highly abnormal; it combines two separate proteins there should be a way
    to specifically attack it while leaving other cells alone.

    The anti-fusion drugs have already been successful (Gleevec — BCR-ABL fusion protein in leukemia).
    The liver patient had a fusion and this might have involved the BSG gene which is of high relevance to 3-BP effectiveness.
    The TRK patients and the liver patients exhibited ongoing responses to monotherapy.
    This suggests that the fusion cancers are locked into their addictions without an easy resistance escape route.

    This article notes that up to 20% of cancer morbidity is associated with fusion proteins and in fact 50% of prostate cancer has the TMPRSS2-ERG fusion. Do they have any drugs in development for this?

    “The total number of gene fusions is now estimated to be 10 000, with over 90% of these being identified in the past 5 years due to advances in deep-sequencing and fusion detection algorithms (12). The prevalence of gene fusions varies widely between cancer types (10): at one extreme, gene fusions occur in (and frequently drive) 90% of all lymphomas, over half of leukemias (13), and one third of soft tissue tumors (14). In prostate cancer, one specific fusion (TMPRSS2-ERG) is the most common genetic alteration, being found in over 50% of patients (15). However, many recurrent gene fusions occur at low frequencies, such as the KIF5B-RET fusion, which is present in 1–2% of lung adenocarcinomas”
    {Strangely they do not mention TRK above.}

    https://academic.oup.com/nar/article/44/10/4487/2516680/Discovering-and-understanding-oncogenic-gene

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11. Here’s a list of fusions from COSMIC.
    Really wonder if there might be some more good targets.
    http://cancer.sanger.ac.uk/cosmic/fusion

    Would love to know how patients respond to different treatments conditioned on Fusion status.
    Fusion Samples Mutations Papers

    BCR-ABL1 8638 5412 233 xxx Gleevec
    TMPRSS2-ERG 6264 2623 114 xxx 50% of prostate patients
    EWSR1-FLI1 2132 1332 164
    EML4-ALK 11213 701 508
    KIAA1549-BRAF 1383 612 79 xxx BRAF
    CCDC6-RET 6833 593 162
    SS18-SSX1 1313 577 135
    PML-RARA 545 544 36
    PAX3-FOXO1 1163 382 72
    NCOA4_ENST00000452682-RET 4431 358 136
    ETV6-RUNX1 2277 357 42
    FUS-DDIT3 627 351 47
    SS18-SSX2 1314 348 136
    NPM1-ALK 1344 319 86
    KMT2A-AFF1 2465 308 74
    TCF3-PBX1 3645 301 53
    STIL-TAL1 1771 284 29
    COL1A1-PDGFB 399 262 51
    CRTC1-MAML2 632 253 36
    NAB2-STAT6 295 246 12
    EWSR1-ATF1 357 179 45
    ETV6-NTRK3 1059 144 47 xxx LOXO-101
    EWSR1-ERG 1639 122 90
    EWSR1-WT1 267 121 55
    DNAJB1-PRKACA 186 107 6 xxx Liver Patient
    PAX7-FOXO1 981 100 56
    FUS-CREB3L2

    ETV6-NTRK3 1059 144
    TPM3-NTRK1_ENST00000392302 629 32
    LMNA-NTRK1_ENST00000392302 38 2
    QKI-NTRK2 96 2
    TFG-NTRK1_ENST00000392302 495 2
    NACC2-NTRK2 96 1
    TP53-NTRK1_ENST00000392302 38 1

    KIAA1549-BRAF 1383 612

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12. D, LOXO-101 is very impressive.

    When you look at page numbered 10 in the pdf, you see 6 patients who had tumor growth.
    If you notice on the bottom of the page numbered 15, there are 6 patients who never achieved a response and stopped treatment
    even before 1.8 months. These patients must have been severely ill. Most trials would not accept them.

    Without these patients almost everyone would have achieved at least a response.
    When they get this out to real world patients the treatment will do even better.
    Think what happens when these patients could be treated at stage 2 or 3!

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13. I am posting this here as it seems the most appropriate place, and the information may help someone else.
    Standard PET/CT has low sensitivity for prostate cancer, making it difficult to determine the extent and location of early spread. There is a need for more accurate scanning techniques when PET/CT and bone scans are inconclusive. We used the C-11 acetate scan after standard imaging was inconclusive and were then able to determine the exact location of mets. At that time, the Axumin scan had not yet been FDA approved, but now it is, so that one may be the easiest to access.

    Axumin PET (aka Fluciclovine F18/ FACBC): http://paact.help/new-pet-scan-approved-for-prostate-cancer-for-psa-recurrence-after-treatment/
    Similar accuracy to C-11 Acetate PET. Now FDA approved, availability is becoming more wide spread.

    C-11 Acetate PET: http://www.phxmi.com/ (only offered in phoenix)
    We had a C-11 acetate scan done in Phoenix and found it accurate and extremely helpful. It can confirm or refute questionable CT and bone scan findings, and show additional lesions that CT/bone scan were unable find. Dr. Almeda, who reads them, has interpreted over 1,500 scans.

    Choline C-11 PET: http://www.mayoclinic.org/tests-procedures/choline-c-11-pet-scan/home/ovc-20156994 (Only offered at Mayo clinic)
    Same idea as the C-11 acetate PET, but the C-11 acetate is more sensitive

    Galium 68 PMSA PET: http://www.pet.theclinics.com/article/S1556-8598(16)30138-9/fulltext
    The Prostate Oncologist I spoke to believes this scan is more sensitive and accurate than the others. It is available through clinical trials and through UCLA:http://urology.ucla.edu/psma-pet-imaging
    https://clinicaltrials.gov/ct2/results?term=gallium+pet&Search=Search

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    1. As an update, Ga 68 PSMA PET is outperforming other PET scans for prostate cancer. Although it is still not widely available, this article has a map of locations that offer it as well a comparison of performance with other novel prostate PET scans: https://www.sciencedirect.com/science/article/pii/S1879850017302060
       This type of scan can be imperative for those who are considering targeted therapy instead of just generalized chemo and androgen deprivation. There are some nice studies coming out on the treatment of oligometastatic prostate cancer using Stereotactic Body Radiation Therapy, with even some reported “cures” (5 years with PSA <0.2 not on ADT). I will post on that later today. My best to everyone.

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       1. For those with oligometastatic prostate cancer (early metastasis with only a handful of lesions) androgen deprivation and chemo used to be the main treatment with radiation used only for palliative care. Now studies are showing that a specific type of radiation called Stereotactic Body Radiation Therapy (SBRT) with an intention to cure, is providing very good outcomes.

          In this study half of individuals who received a single treatment of SBRT where able to avoid androgen deprivation for at least two years: https://www.europeanurology.com/article/S0302-2838(18)30429-9/abstract?ct=t(EMAIL_CAMPAIGN_7_13_2018_14_40)&goal=0_bc8795358a-78c2b5df4d-199203717&mc_cid=78c2b5df4d&mc_eid=2cf1d76790

          This study concluded: “SBRT offers high local cancer control rates in bone oligometastases of PC and should be evaluated with the aim of curation or to delay modification of systemic treatment.”
          https://bmccancer.biomedcentral.com/articles/10.1186/s12885-017-3341-2

          This study took a multimodal aggressive approach to oligometastatic prostate cancer, including SBRT and concluded that: “A sequentially applied multimodal treatment strategy can eliminate detectable disease in selected patients with metastatic spread at diagnosis. The endpoint of undetectable PSA after testosterone recovery should be considered when evaluating new approaches to rapidly set priorities for large-scale testing in early metastatic disease states and to shift the paradigm from palliation to cure.”
          They actually had long-term ADT-free remissions, including 5 years.
          https://www.goldjournal.net/article/S0090-4295(16)30850-0/abstract

          There are additional supportive studies for this treatment approach for prostate cancer, and for other cancers. I wanted to post this because many doctors do not stay informed of the latest literature, so it is up to us to be informed. For example, when we brought the possibility of SBRT up with my husband’s radiologist, he became angry and refused to see us if we pursued such a “foolish” treatment. Needless to say, we found another doctor. The point is that we must inform ourselves of the latest and most promising treatments for our situation and not assume that our oncologist is aware of the best options.

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14. Advanced prostate cancer (and other cancers too) can have two tumor suppressors silenced, PTEN and p53. Loss of PTEN leads to activation of the oncogenic PI3K/Akt/mTOR pathway. Deguelin and Rotenone selectively kill PTEN null cells.
    Mitochondrial Complex I Inhibitors Expose a Vulnerability for Selective Killing of Pten-Null Cells. PMID: 29617673

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15. Hi Daniel-
    Thanks for your June, 2019 update to this post. I found this reference particularly useful:
    The Metabolic Phenotype of Prostate Cancer https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5474672/
    After a year of being off of androgen deprivation (zytiga and lupron) my husband’s PSA went from <0.006 to 0.029. He had also discontinued most of his supplements, despite my protest. He is now back on them and we are retesting PSA in a few days. This article was useful in deciding which pathways to prioritize if we need to start ramping up our therapy. We suspect he is still androgen deprivation responsive, but are going to try to avoid androgen deprivation, if possible. Also finding the HCA+ALA, Cholesterol synthesis inhibition and Zinc ionophor posts very helpful in formulating a plan. I will post here what we implement and the results or if I have questions for all of you.

    On a side note, we tried the supplement Prostasal, my husband's reaction was similar to when he tried an estrogen patch while on androgen deprivation in an attempt to support bones, memory and help with hot flashes. Specifically, he began to have breast tenderness, mood swings, fatigue and weight gain immediately and discontinued because he felt the side-effects outweighed the benefits. We also have a friend who believes it controlled his low grade, confined prostate cancer for 8 years (he also had estrogen like side-effects). Looking at the ingredients, I wonder if it isn't contaminated with a synthetic estrogen. This is just an informational post, no need to respond, please focus your energies on those who have greater need.

    Warmly,

    Shanti

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    1. Hi dear Shanti,

       Thank you for the update. Indeed Prostasol and Nutrition 2000 seem to lead to similar side effects as you mentioned. I also know some people who experienced this as well but also a PSA reduction. Normally, I would expect this could be the results of Regrestrol components, but the reaction seems to be much stronger, indicating, as you said, possible contamination with estrogen. If I can help with anything please let me know.

       Kind regards,
       Daniel

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16. Hi All-
    I would like your thoughts on this initial protocol for stage IV prostate cancer. Anything I should add or take away? My husband’s PSA has started to increase. It is believed he has a low PSA producing cancer, so it makes increases more significant, and, so far, his doubling time is about a month. Here is his history in a nut shell:
    62 yo Male
    Oct 2016 PSA 10, Gleason 9
    Feb 2017 radical prostatectomy
    April 2017 post prostatectomy PSA 5
    May 2017 C11-Acetate Scan reveals 1 met to left lung, 1 met to sacrum and multiple positive pelvic and abdominal lymph nodes
    May 2017- May 2018- Zytiga+Lupron+Prednisone+Xgeva, PSA is less than 0.006 but side effects are eroding quality of life
    May 2018-May 2019- We decide to take a break from ADT and are using only supplements. PSA is less than 0.006 for 1 year
    June 2019, PSA 0.029. July 2019 PSA 0.058

    We would like to avoid androgen deprivation for as long as possible AND want to find something that works before the dreaded androgen deprivation resistance sets in. Right now, the androgen deprivation (assuming he is still sensitive) can serve as a re-set button if needed. The main metabolic pathways we are focusing on are: Zinc metabolism, copper depletion, lipid use and synthesis, and mitochondrial inhibition.

    Altered Zinc metabolism of prostate cancer:
    Clioquinol 3% cream -1g twice a day (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6392423/, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6578577/- Thank you J)
    Chloroquine 250mg/day
    zinc -50mg twice a day

    Copper depletion:
    Silver 10ml/day (zinc should work synergistically)

    Lipid use and synthesis:
    HCA 1.5g twice a day
    Lipoic acid 300mg extended release twice a day
    Tocotrienols 1 twice a day https://www.lifeextension.com/Vitamins-Supplements/item01400/Super-Absorbable-Tocotrienols
    Atorvastatin 10mg

    Mitochondrial Inhibition:
    Metformin 1000mg extended release
    Berberine 1000mg twice a day
    Doxycyclin 100mg /day

    Other:
    Honokiol, Ursolic acid, Xanthumol

    We are also considering adding IVC and oral vitamin C to synergize with the Doxycycline (we have used IVC before, but not combined with Doxy). Maybe also Artemisinin/Artemisia (one week on-one week off). If everything is tolerated, we may also add in Dipyridamole and Fenbendazol or Mebendazol and dutasteride.

    He currently takes:
    Berberine 1000mg
    Lycopene 45mg
    Pomi-T
    Aspirin 82mg
    CoQ10 200mg
    PQQ 20mg
    Metatrol 2/day
    Apigenin 50mg bid
    Grape Seed Extract 100mg
    Pectasol 2 scoops
    Tart Cherry
    Luteolin 50mg
    Mega Green Tea 45% EGCG
    Vitamin D 6000IU, 1 oz Juiced turmeric (about 5 roots)
    Basentabs
    resveratrol 150mg/ day
    Diet: Vegan diet that is mostly vegetables, nuts, beans and green juices

    In the past he has tried and not tolerated: Cimetidine, vitamin K2 and K3, Prostasal, Diclofenac
    Thank you all for any thoughts and help!
    -Shanti

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    1. Hi Shanti,
       could you tell us more about your husband’s supplements plan; when did he start each supplement, does he take all supplements continuously, etc.
       Best Regards,
       Johan

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       1. Hi Johan,
          Thank you for your reply. He took all supplements continuously from Feb 2017 through March 2019, at which point all but the vitamin D were discontinued (my husband doesn’t like taking them and the undetectable PSA gave a false sense of security). I do not know if discontinuing coincided with the PSA increase. We reinitiated all supplements with the June PSA reading of 0.029 and approximately 3 weeks passed between supplement reinitiation and the July reading of 0.053.
          His supplement regimen has had some variation in it, and at various times he has used artemisinin (1 week on/one week off), shark liver oil, xanthohumol, Coriolus, and reishi.
          Warmly,
          Shanti

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    2. Hi Shanti,
       you might want to consider the following:
       -In hormone-sensitive cancers, the flavonoids apigenin, quercetin, and genistein may act in a biphasic manner.
       -Resveratrol, again the biphasic properties of this compound should be noted:
       https://tandfonline.com/doi/abs/10.1080/01635581.2017.1359309
       -Myricetin:
       https://www.karger.com/Article/FullText/492009
       https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4631581/
       -Sodium phenylbutyrate antagonizes prostate cancer through the induction of apoptosis and attenuation of cell viability and migration
       https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4869668/

       Best Regards,
       Johan

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       1. Hi Johan,
          I very much appreciate your responding providing these links. We previously eliminated quercetin and genistein from our supplement regimen due to this type of conflicting information. I had read a study in which a minority of prostate cancers had androgen receptors that could use genistein for growth, so we decided not to take chance. Daniel has a post on high dose (in the gram range) genistein and I did order a kilo in case we need to try it as a strategy at some point. I will spend some time reading the links you sent this evening and adjust our regimen accordingly.
          Thanks again,
          Shanti

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          1. Hi Shanti,
             It’s impossible to know if the rise in PSA has anything to do with discontinuing the supplement plan, but at least the rise in PSA can’t be attributed to those supplements. The fact he took those supplements for an extended period of time without a rise in PSA does add confidence the supplement cocktail is(was) beneficial. That said, the PSA levels now continue to rise after reintroducing the supplements.

             As mentioned in my previous reply below(or above), there’s a case to be made to exclude apigenin and resveratrol from the supplement plan, or to use in rotation (for example one or two months on/off).
             In combination with Artemisinin, Resveratrol does seem to produce synergy in anticancer activity. PMID: 25048878

             When taking Coq10, consider adding β-glucan.

             Combination Therapy with Glucan and Coenzyme Q10 in Murine Experimental Autoimmune Disease and Cancer. PMID: 29848676

             When taking lycopene, consider adding sulforaphane.

             Combinations of Tomato and Broccoli Enhance Antitumor Activity in Dunning R3327-H Prostate Adenocarcinomas

             A phase II study of sulforaphane-rich broccoli sprout extracts in men with recurrent prostate cancer. PMID: 25431127

             Consider adding IP6

             Inositol Hexaphosphate Inhibits Tumor Growth, Vascularity, and Metabolism in TRAMP Mice: A Multiparametric Magnetic Resonance Study
             http://cancerpreventionresearch.aacrjournals.org/content/6/1/40

             Consider taking Magnesium

             Magnesium Chloride increases apoptosis and decreases prostate cancer cells migration
             https://www.ffhdj.com/index.php/ffhd/article/view/368/699

             Honokiol + Artemisinin synergy
             https://www.researchgate.net/publication/285726504_Experimental_studies_of_honokiol_in_combination_with_artemisinin_on_anti-tumor_effect_of_SPC-A-1_cells_in_vitro

             Consider using liposomal curcumin, in addition or to rotate with the turmeric juice.

             Consider adding flax seeds to his diet.

             Best Regards,
             Johan

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          2. Hi Shanti,
             I’m unable to post another response, I’ve sent it to Daniel via email

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             1. Hi Johan,
                Thanks again for the great links. We removed resveratrol from our regimen… too risky https://www.nutraingredients-usa.com/Article/2010/07/20/Researchers-Resveratrol-a-double-edged-sword-for-prostate-cancer. I couldn’t find any negative studies on apigenin, if you have a link, I would be grateful. Thank you also for the link to the phenylbutyrate, interesting that this is also used by the controversial Dr. Burzynski. Your second post came through in my email notifications, so I will take a look at it now.
                Warmly,
                Shanti

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                1. Hi, I’ve posted over at the forum if you don’t mind, I’ve posted so many times here without getting through 🙂

                2. phenylbutyrate is indeed used by dr.burzynski, we used his A10 antineoplastons back in 2003 (when sodium is metabolized in the body it produces byproducts, also called antineoplastons) along with tamoxifen, melatonin, and lomustine, which resulted in a recurrent glioblastoma to shrink and eventually disappear.

                3. * when sodium phenylbutyrate is metabolized in the body it produces byproducts…

             2. Hi Johan,
                That is an amazing testimonial! It is hearing about such cases that give us hope. Do you think Burzynski’s success with phenylbutyrate came because of the way he combined it with other medications and chemo? The studies I saw on it not authored by him seem to show minimal success, but I am learning that the power is often in how things are combined rather than a single agent.

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                1. Hi Shanti, I think back then Burzinsky was mainly treating patients with antineoplastons, I got the impression he was trying to find the most effective dosage, and at high dosages, the sodium is a big problem. Nowadays he also uses low dose chemo and many of the drugs we now know can be used against cancer e.g. metformin. I believe he is a pioneer in the field of repurposing drugs for cancer treatment. Going to his clinic in Texas wasn’t an option for my father-in-law but back then he was selling A10 antineoplastons in a product called Aminocare A10. It still exists but no longer has the antineoplastons, as he isn’t allowed to sell it anymore.

                2. Hi Johan,
                   Thank you for your insight in to this.
                   Shanti

    3. Dear Friends,
       Good news 🙂
       After implementing the following (in addition to the supplements he already takes):
       2.5mg HCA bid
       300mg ALA bid
       Tocotrienols bid
       500mg SR metformin bid
       50mg zinc
       3% clioquinol cream 1g topically/day (zinc ionophore)
       15ml 10ppm silver (sovereign silver) bid
       Nebulization of silver, water, sodium bicarb solution bid x 7 min

       My husband’s PSA has held steady at 0.051 (May= <0.006 // June, 20 = 0.029 //July 11 =0.053 // Aug 2 = 0.051). This means we are on the right track!
       We have also made some minor adjustments to our supplement list (which can be viewed in an earlier post), thank you Johan for your suggestions. We will be adding other tactics as tolerated, my husband did not do well with chloroquine or fenbendazole (diarrhea, nausea, cramping, fatigue). We are considering adding in LDN as it has synergy with ALA. Daniel posted elsewhere that it is important for a cancer to express TLR4 when considering LDN, which prostate cancer does: https://www.ncbi.nlm.nih.gov/pubmed/29928275. I will be researching this afternoon, but would be interested if anyone has thoughts or experience with LDN and prostate cancer.
       I am eternally grateful to all of you for your help and support,
       Shanti

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       1. Dear Shanti,

          I thought I responded to your kind and positive comment here but somehow I probably forgot to push “reply” as I did it while travelling. I was happy to read the positive news and I wish you continued success. Indeed, LDN is a good one to add to the cocktail. (Looking at the silver dose you mentioned you are using, I realised it is about 10x lower compared to what the man in the case report cited in the silver post used.).
          If you have questions about other subjects where I could help, please let me know. I am now back home and should be able to find the time (as I promised earlier).

          Kind regards,
          Daniel

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          1. Hi D,
             Your comment on the silver dosing is noted. I was going off of the “dosing section” in the blog post, but I can appreciate why you give the dosing as you did in that section with encouragement to consider higher dosing with active cancer. I think we will continue with our current dosing and increase pending our upcoming scan and PSA reading.
             By the way, my husband’s baseline ceruloplasmin in May was 16.9 mg/dL (range 16-31), after a month of silver and 50mg zinc once or twice a day it hasn’t changed and is at 17. We probably need higher silver dosing or dosing for a longer time period to bring it down. We also tested our water for copper, which was negative. I could start him on TM since it is best with low volume disease, but his consistently low WBC stop me from doing so (last reading WBC 2.5 range 3.4-10.8).
             Glad to have you back ?,
             Shanti

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       2. Hi Shanti, that’s such great news!! You´re an inspiration for all of us here!
          Say hello to your husband!
          Regards
          Johan

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          1. Thanks Johan, I think I was so relieved the PSA didn’t go up last month that I got over-enthusiastic, I still think it is because of what we are doing, but will take more time to confirm.
             -Shanti

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             1. I know it’s a roller coaster ride but stable PSA is good.
                Take care
                Johan

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       3. Husband’s Axumin PET was negative for active cancer. Our oncologist was concerned it had morphed into a non-PSA producing aggressive prostate cancer of the neuroendocrine variety. Thankfully that is not the case. We are holding at PSA of 0.051, off of all ADT for 1 year.

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          1. That’s good to hear, Shanti.
             Have a wonderful weekend!
             Regards
             Johan

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          2. Great, Shanti! Thanks for the update!

             Kind regards,
             Daniel

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          3. Shanti, let us know the latest PSA for your husband. I am also tracking my own PSA recurrence after an oligometastatic outburst / SBRT treatment in 2014. Too much for a reply here, will detail in separate posting.

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             1. Hi Kevin,
                PSA Dec 14th was 0.21. My husband’s system is so sensitive that he hasn’t been able to tolerate the off label meds we have tried (statin, clioquinol, fenben, doxy, nitro-patch, and others). IVC doesn’t seem to help, not sure yet about IV artesunate. We just finished a round of DCA, which caused significant fatigue and leg pain (which has resolved), but we figure that if it knocks it back, it is worth it. We will know more next PSA test. He is still hormone-sensitive and off all ADT.
                Best,
                Shanti

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17. We are now ALSO considering 3BP (https://www.ncbi.nlm.nih.gov/pubmed/30928407- Thank you Jcancom). I need to reread the 3BP sections of this site and figure out how to work it in and what of the items we are using it doesn’t work with (MCT1 inhibitors, glutathione regenerators etc). J also pointed out that the fact that my husbands mets were brightly lit on an acetate scan increases the chance they will respond to 3BP. My concern with 3BP is reports of tumor being made very aggressive without a complete response-I would love insight on this.

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    1. Hi Shanti,

       If you are interested in 3BP, when I come back from holiday please remind me to contact a man with whom I was in contact 4 years ago. He was using first DCA and after 3BP to control/suppress his PSA. He first used DCA and that was helping his PSA but he experienced nephropathy so he had to stop and switch to 3BP. He was taking it orally. His job at that time was as a cancer scientist in a pharma company working on chemo in France as I remember, so he could also do studies in the lab. He claimed good results with 3BP and he gave me all the details on how he was using it. I remember one-two years after our first contact on Cancer Compass he was still using it.

       Kind regards,
       Daniel

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18. Hi Daniel,
    Yes, I am very interested in anything that may work and would very much appreciate being in contact with such an individual. I will reach out to you in a few days when you are back. We briefly used DCA along with 2DG (both oral) and some other meds, but discontinued as PSA was undetectable on ADT.
    Thank you,
    Shanti

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    1. Hi Shanti,

       I was checking the comments on Medicor web page and saw this statement from Dr. Khan: “Yes DCA often does work for chemo- or hormone-resistant prostate cancer”. https://medicorcancer.com/new-dca-publication-world-first/

       Kind regards,
       Daniel

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       1. Thanks D!
          That is good to know and we would consider its use again. I think you have seen this but I didn’t see it on the DCA blog, some statistics from medicore on response rate: http://medicorcancer.com/dca-therapy-data/. Would be nice to get newer data, but at least they provide something, which many other clinics do not.
          Warmly,
          Shanti

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19. Hi All-
    As my husband also has two small mets to his left lung, we are also looking into what we can do with getting substances in direct contact with the lung mets via nebulization. As his PSA recently started to increase, the same persistent cough he had before androgen deprivation began to return. It has actually gone away since implementing some of the items outlined in the protocol I posted above. We won’t know if this is related to an improvement in the cancer until later this month with a PSA and PET. I know 3BP can be nebulized, but we aren’t using that at the moment. Does anyone have experience nebulizing therapeutic substances for lung mets? There is anecdotal evidence for nebulized sodium bicarbonate, H202 and colloidal silver for use in cancer. All of these have a history of nebulization for use in COPD, asthma, pneumonia, infection etc and I think their use is relatively safe as long as one stays with in the established dose based on collective experience.

    Here is some info on dosing:
    http://healyourselfathome.com/HOW/THERAPIES/SODIUM_BICARBONATE/sodium_bicarbonate_nebulizing.aspx
    http://www.healyourselfathome.com/HOW/THERAPIES/H2O2/nebulizing_H2O2.aspx
    https://livelovefruit.com/nebulize-colloidal-silver-support-lung-health/
    https://mountainwellbeing.com/nebulizing-colloidal-silver-support-lung-health/

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    1. Dear Shanti,

       I do have experience with nebulizers. My wife did used DMSO, DMSO+3BP (extremly low dose), and also tried Methyl Jasmonate a little. I also considered H202 and colloidal silver. Nebulizing Helleborus niger from Helixor may also help.It’s very affordable and can be found at German pharmacies. I always thought nebulizing is a very relevant treatment route for lung tumors (and others). Please let me know if I can help with anything on this line. I may not remember all the details but I can always look back at my notes. All what we did was safe with no side effects.

       Regarding the cough, I do not expect that is related to the lung ments since those are very small to my understanding. What I also find a relevant idea for those who deal with lung tumours is to have a vaccine such as Pneumococcal conjugate vaccine done (Pneumococcal infections are an important cause of infections in cancer patients).

       Kind regards,
       Daniel

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20. Hi Daniel,
    If we begin to use 3BP, we will most certainly do some of the application via nebulization. We started on Sat with nebulization of colloidal silver and 2% sodium bicarbonate solution for 5-10mg and this has been well-tolerated with my husband reporting a decrease in respiratory/nasal inflammation, but it is early in the treatment. Thank you for the additional suggestions, I will look into them.

    For those who have interest, here is an article on why chemo is not delivered via nebulization (which was something I was wondering). In short, there are multiple challenges including lung toxicity, only reaching the periphery of the tumor, contamination of the environment with vapor escaping from the nebulizer, among others.
    https://www.mdpi.com/2072-6694/11/3/329/pdf

    Warmly,
    Shanti

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21. Hi All-

    For those who have challenges following a vegan plant based diet, the low polyamine diet could be a viable alternative. Best results would likely be achieved by following a low polyamine+vegan diet. This study is from 2010, but I hadn’t seen it posted and the hormone-refractory men on the low-polyamine diet appear to have a doubling of survival time.

    “Median cancer-specific survival times for the intervention groups as a whole compared to controls are 36 months versus 17 months, respectively (P = 0.004)”

    Polyamine reduced diet (PRD) nutrition therapy in hormone refractory prostate cancer patients.
    https://www.ncbi.nlm.nih.gov/pubmed/20106631

    Abstract
    BACKGROUND:
    Reducing polyamine uptake by selecting low polyamine-containing foodstuffs and reducing bacterial gut production can improve performance status and pain control in hormone refractory prostate cancer (HRPC) patients. Long term PRD observance and tolerance were assessed. Cancer specific survival was studied in function of PRD and time of PRD initiation.

    METHODS:
    Twenty-six volunteers, age: 68+/-10 years with metastatic HRPC accepted a polyamine reduced diet and partial gut decontamination with oral neomycin or nifuroxazide (750 mg daily, one week out of two). Time from HRPC to PRD initiation was 10+/-8 months. WHO performance status, EORTC pain scale, body weight, blood counts and serum proteins were regularly assessed. Sixteen other HRPC patients eating a normal diet served as “controls”.

    RESULTS:
    Mean diet observance is 25+/-24 months. Tolerance is good. WHO performance status and EORTC pain scales were significantly improved respectively at 3 months (0.5+/-0.7 vs 0.7+/-0.9: p=0.03) and 6 months (0.5+/-0.8 vs 1+/-1.3, p=0.02) compared to initial values. Median cancer specific survival times after HRPC and PRD initiation are respectively 36 and 21 months. Eleven PRD patients started the diet before a 9 months cut-off period (after HRPC) and 15 patients after. Median cancer specific survival times for these two groups of patients are respectively 44 and 34 months, p=0.014. Median cancer specific survival times (after HRPC) for PRD patients compared to controls are 36 vs 17 months (p=0.004).

    CONCLUSIONS:
    Polyamine-reduced diet is well observed and tolerated. It seems to improve and/or maintain quality of life for HRPC patients. Early PRD initiation in HRPC is promising and may impact favorably cancer specific survival. These results open a rationale for PRD in HRPC management and warrant further investigation.

    The Denver Naturopathic Clinic has put together a nice listing of low/moderate/high polyamine foods:
    http://www.denvernaturopathic.com/EclairDiet.htm.

    Group 3 foods, the foods with the highest polyamine content and that were most important to avoid included:
    Calamari, oysters, muscles, crab, scallops, liver mousse, chitterlings, duck-liver pate´, pork liver pate´ garlic, chervil, tarragon, cabbage, broccoli, parsley, mushrooms, green peas, eggplant, tomatoes, bone marrow, oranges, hazelnuts, almonds, pistachios, peanuts, bananas, wheat, mustard, tinned gherkins, tomato paste, instant mashed potatoes, minced spinach, lentils, chickpeas, ratatouille, and sauerkraut.

    Group 2 foods that contain moderate levels of polyamine:
    fresh salmon, beef and ox tongue, chicken, rabbit, veal, lamb, beef, ham, garlic sausage, paella, red beans, radish, chicory, leek, endives, potatoes with skin, spring potatoes, Brussels sprouts, lettuce, cucumber, melon, goat cheese, oat, rye and whole breads, ketchup, grapefruit and orange juices.

    Group 1 foods with the lowest polyamine content that could be consumed freely:
    scampi, crayfish, hake, cod, whiting, smoked and canned salmon, tinned tuna, bacon, sausages, chipolata, pork, turkey, chorizo, minced pork, salami, onions, celery, carrots, green cabbage, beetroot, skinned potatoes, sorrel, string beans, small tomatoes, peppers, canned vegetable soup, raisins, apples, prunes, pears, avocado, peach, dates, pineapple, grapes, kiwi, lemon, strawberries, fruit salad, butter, cream, milk, yoghurt, soft cheese, Emmental, goat cheese without rind, pasteurized brie, grated cheese, camembert, eggs, rice, semolina, pasta, white bread, sugar, pancakes, chocolate eclair, honey, cookies, pound cake, chocolate, lemon pie, strawberry pie, apricot, strawberry, prune and raspberry jams, salt, pepper, oils, vinegar, coffee, tea, cider, cola, whisky, cognac, port, wine [God Bless the French! TK], apple, grape and apricot juices, beer, tropical fruit cocktail, and tomato juice.

    The list somewhat flies in the face of convention on what a prostate cancer patient should eat. Polyamines likely play a role in other cancer types as well: https://www.ncbi.nlm.nih.gov/pubmed/?term=polyamine+%5Bti%5D+cancer

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22. Hi All-

    For those who have challenges following a vegan plant based diet, the low polyamine diet could be a viable alternative. Best results would likely be achieved by following a low polyamine+vegan diet. This study is from 2010, but I hadn’t seen it posted and the hormone-refractory men on the low-polyamine diet appear to have a doubling of survival time.

    “Median cancer-specific survival times for the intervention groups as a whole compared to controls are 36 months versus 17 months, respectively (P = 0.004)”

    Polyamine reduced diet (PRD) nutrition therapy in hormone refractory prostate cancer patients.
    https://www.ncbi.nlm.nih.gov/pubmed/20106631

    Abstract
    BACKGROUND:
    Reducing polyamine uptake by selecting low polyamine-containing foodstuffs and reducing bacterial gut production can improve performance status and pain control in hormone refractory prostate cancer (HRPC) patients. Long term PRD observance and tolerance were assessed. Cancer specific survival was studied in function of PRD and time of PRD initiation.

    METHODS:
    Twenty-six volunteers, age: 68+/-10 years with metastatic HRPC accepted a polyamine reduced diet and partial gut decontamination with oral neomycin or nifuroxazide (750 mg daily, one week out of two). Time from HRPC to PRD initiation was 10+/-8 months. WHO performance status, EORTC pain scale, body weight, blood counts and serum proteins were regularly assessed. Sixteen other HRPC patients eating a normal diet served as “controls”.

    RESULTS:
    Mean diet observance is 25+/-24 months. Tolerance is good. WHO performance status and EORTC pain scales were significantly improved respectively at 3 months (0.5+/-0.7 vs 0.7+/-0.9: p=0.03) and 6 months (0.5+/-0.8 vs 1+/-1.3, p=0.02) compared to initial values. Median cancer specific survival times after HRPC and PRD initiation are respectively 36 and 21 months. Eleven PRD patients started the diet before a 9 months cut-off period (after HRPC) and 15 patients after. Median cancer specific survival times for these two groups of patients are respectively 44 and 34 months, p=0.014. Median cancer specific survival times (after HRPC) for PRD patients compared to controls are 36 vs 17 months (p=0.004).

    CONCLUSIONS:
    Polyamine-reduced diet is well observed and tolerated. It seems to improve and/or maintain quality of life for HRPC patients. Early PRD initiation in HRPC is promising and may impact favorably cancer specific survival. These results open a rationale for PRD in HRPC management and warrant further investigation.

    The Denver Naturopathic Clinic has put together a nice listing of low/moderate/high polyamine foods:
    http://www.denvernaturopathic.com/EclairDiet.htm.
    The list somewhat flies in the face of convention on what a prostate cancer patient should eat. Polyamines likely play a role in other cancer types as well: https://www.ncbi.nlm.nih.gov/pubmed/?term=polyamine+%5Bti%5D+cancer

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23. Yesterday I came across this article:
    https://www.ncbi.nlm.nih.gov/pubmed/23671572/
    From an objective of rectifying mitochondrial defects in cancer cells and to establish mitochondria as a potential anticancer drug target, understanding the role of functional mitochondria in reversing oncogenic properties under a cancer nuclear background is very important. Here we analyzed the potential reversal of oncogenic properties of a highly metastatic cell line with the introduction of non-cancerous mitochondria. Cybrids were established by fusing the mitochondria DNA depleted 143B TK- ρ0 cells from an aggressive osteosarcoma cell line with mitochondria from benign breast epithelial cell line MCF10A, moderately metastatic breast cancer cell line MDA-MB-468 and 143B cells. In spite of the uniform cancerous nuclear background, as observed with the mitochondria donor cells, cybrids with benign mitochondria showed high mitochondrial functional properties including increased ATP synthesis, oxygen consumption and respiratory chain activities compared to cybrids with cancerous mitochondria. Interestingly, benign mitochondria could reverse different oncogenic characteristics of 143B TK(-) cell including cell proliferation, viability under hypoxic condition, anti-apoptotic properties, resistance to anti-cancer drug, invasion, and colony formation in soft agar, and in vivo tumor growth in nude mice. Microarray analysis suggested that several oncogenic pathways observed in cybrids with cancer mitochondria are inhibited in cybrids with non-cancerous mitochondria. These results suggest the critical oncogenic regulation by mitochondrial-nuclear cross talk and highlights rectifying mitochondrial functional properties as a promising target in cancer therapy.
    —- we have been talking about the different metabolism in prostate cancer cells from other types of cancer… Well, what if it is the same problem? The normal mitochondria in prostate cancer cells are not supposed to oxidate citrate but cancerous cells do… And mitochondria from other cancer types are suppose to use oxidative phosporylation yet they don’t do it… Then the mitochondria are the real problem and the focus should be on making them functional again

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24. Hi Yudiatheska,
    Based on this paper and other that have been published, I agree, dysfunctional mitochondria play a huge role in cancer initiation and progression. Cancer universally shows dysfunction or altered metabolism as part of its strategy to survive and multiply. It is certainly odd that prostate cancer ramps up the kreb cycle in early cancer, only becoming highly glycolytic in later stages. It is certainly something we have taken into consideration as we have designed our approach to my husband’s prostate cancer. I think it useful for everyone to investigate their cancer’s “metabolic phenotype” to help choose strategies and find out if there are any “Achilles heel”. I love the idea of returning mitochondria to normal function and found this paper outlying some strategies: https://isom.ca/article/mitochondrial-correction-new-therapeutic-paradigm-cancer-degenerative-diseases/. Nonetheless, it seems our most effective tools are still weakening the cancer cell through metabolic therapies and then trying to kill them while defenses are low. The mitochondria seem unwilling to revert back to normal easily.
    Warmly,
    Shanti

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    1. Thank you for the link!

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    2. Shanti! How are you doing? It has been a while since I read your latest post about your husband’s condition. How are you both?

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25. Hi Yudaitheska,
    Thanks for asking! Since I work in the health/supplement industry, I have been extraordinarily busy, which I don’t mind, but it leaves less time to participate in this forum which is so dear to my heart. Anyhow, for all my learning and putting together protocols for my husband, he tends to be intolerant to most medications, with even their lowest doses resulting in side-effects that are not tolerable for the long term. He gets an ‘A’ for effort as I have a drawer packed with tried and failed off-label meds. He does ok with most natural stuff, (IVC, ozone, B17, artesunate, supplements), but we haven’t seen that these slow his PSA. His last PSA reading was 0.89. He has been off all conventional cancer treatment for almost 2 years but his PSA goes up by about 50% each month and we have agreed with his doctor that he will start therapy again when it reaches 1. We have an appointment with his oncologist this morning, so we will find out if we have reached the threshold. Between last reading and today’s appointment, my husband has used clioquinol and fenbendazole as he could tolerate them, so we will see if it was enough. Our plan, when PSA reached 1 had been to travel to Germany or India for an emerging treatment called Lu-177, but with travel restrictions as they are, that plan has been delayed, so it will be back on conventional treatment until travel opens up.
    How have you been? I hope you are well and not to negatively affected by all the changes brought by this virus. Wishing you the very best,
    Shanti

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    1. Thank you for your fast reply Shanti! I learned a lot through everything you write. I hope everything works out well for your husband with this new treatment. Usually when prostate cancer patients are below 2 here in Mexico they are told that they have a very good evolution, still most of the focus is on androgen deprivation therapy and when the usual medications don’t work they use ketoconazole. I often ask myself when is the moment to relax a little… When reaching below 0? But then I read your posts and start thinking may be it is when the patient is below 0.0. There aren’t that many resources for the follow up of patients other than a bone scan since most patients use their social security to be treated.
       Anyway… Life is good here in México, I work on the respiratory triage from time to time. Mexico is following a centinel approach to the pandemic so not so many people are tested for COVID we don’t really know officially the extent of the disease but in doctor’s Facebook groups page I can see that my colleagues are struggling but the official word is that we have everything under control… We all buy our own equipment and sometimes we get help from the government or the people. In my case.. Well I don’t know if what I saw with my sister and mother was Corona or a REALLY bad Influenza, my sister got sick in Texas around lasts days of February, headache, fever, dyspnea, cough, was feeling very weak.. I placed an IV line, rehydrated her and use IVC and low dose steroid, a lot of vitamin C and zinc, albutherol and beclometasona inhalers and she got better after almost 10 days… Then my Mom started feeling the same I used the same approach and she got better but this time I did get anxious, she is 65 and things always get more complicated but she evolved very well. None of them got tested since at that time only the people who traveled to China or Italy were suspicious… Then 3 of us started with the headache and conjunctivitis… But that’s it.
       I hope this virus doesn’t get to you or your loved ones in a bad way.
       Good thing to learn so much from here, thanks to Daniel’s effort.

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       1. Hi Yudaitheska,

          Admittedly, many men with metastatic prostate cancer would be thrilled to have a PSA of 0.89, in fact, some never reach zero even when they are initially started on therapy. Above 2 is considered biochemical recurrence of cancer for a man who’s prostate was treated with radiation, and above 0.2 is consider recurrence for a man who has had a prostatectomy. We have been very fortunate that, even though my husband was diagnosed with mets to lung, bone and lymph, he responded very well to ADT/Zytiga and we have even been able to come off of it for almost 2 years with PSA only now reaching 0.9. Even so, since my husband’s PSA was only 5 with all his mets, we know his cancer does not produce much, so a 1 for us may be a 5 for someone else.

          Now for the good news, last month, the PSA reading was 0.89 and it is 0.9 this month, so his PSA basically did not go up. We believe this is due to the clioquinol cream since out of 4 months he used it, the PSA did not go up 3 of those months and one of them, it went down. All other months, it has gone up by 50%. I think that the month where PSA went up despite the clioquinol use, it was because we didn’t use high dose oral zinc along with it. Soooo….. my husband is willing to feel bad for part of the month while he takes the clioquinol to try to keep his PSA down in an attempt to avoid ADT until we can travel for the Lu-177 treatment.

          I am glad you are doing well in Mexico, are you a nurse there? A doctor? It sounds like you and your family may have been exposed, you certainly named the symptoms. At some point perhaps you will get antibody testing. Here, we have several antibody test options available now with good sensitivity and specificity, Quest Labs offers one without a prescription. I can understand how you would get anxious with your mom potentially having the virus, but it sounds like you had a good treatment plan. I am glad she pulled through ok. I am working from home and don’t go out except for walks, we get groceries delivered. I am not concerned so much for myself, but to protect my husband. I hope that things in Mexico continue to be manageable, I worry about what the virus would do if it hit Mexico City or some of the other large cities. Last night I dreamt I was back in San Miguel de Allende at a little taco bar, your post must have triggered the good memory ?.

          Take care of yourself,

          Shanti

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          1. Hi Shanti! I’m a Dr, General Practitioner here in México. In fact the Coronavirus has hit really bad Mexico State and Mexico City. I live in the North of Coahuila, here things are still manageable. I like San Miguel de Allende it’s funny how a few stores and restaurants have things written in English and Spanish. Thank you for all the Information, I really appreciate it. I have come to feel “Cariño” for everyone in this blog. Saludos a su esposo!

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             1. Hi Yudaitheska,
                I am sorry to hear the virus is hitting DF, the numbers are under-reported, so it is not visible to the world. I came to love Mexico very much during my time there. We traveled through so many beautiful places, my favorites were listening to huapango in the the Huasteca, exploring the missions in the Sierra Gorda de Queretaro, and Tamasopo, a hidden treasure where a pristine hot water river bursts forth from a mountain, wow! Anyhow, I’m sure your work there as a doctor is so needed, and thanks also for all your contribution to this amazing blog. Un saludo!
                Shanti

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                1. Correction- Tolontongo is the hot water river 🙂

          2. Taxifolin enhances andrographolide-induced mitotic arrest and apoptosis in human prostate cancer cells via spindle assembly checkpoint activation.

             https://www.ncbi.nlm.nih.gov/pubmed/23382917

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             1. Thanks Johan, I’m surprised that dihydroquercetin isn’t more readily available as a supplement. Hope all is well with you.

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                1. Hi Shanti, life extension had one but it seems they’ve discontinued that product. Here’s one:
                   https://www.stopagingnow.com/VTC/Revolution-Ctrade-Complex
                   I’m fine, thanks for asking. Hope you, your husband and family are well to.

                2. Another one. KAPILAR 100 and 200 TAB of 0,25g (Dihydroquercetin). ANTIOXIDANT EFFECT. Capilar

                   But as you say, not widely available.

             2. Hi Johan, D, and all-
                Do either of you (or anyone) have any personal experience, or know someone who has used Beljanski products? Naturally, I am most interested in the Prostabel. I have looked at their research which is in animals/cell line, so really just checking if you know anyone who has successfully used the product: https://www.natural-source.com/us/shop/all-products/prostabel.html.

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                1. HI Shanti,

                   I think one of Beljanski’s solutions was Rauwolfia vomitoria. I just checked and Postabel contains Prostabel contains Pao pereira and Rauwolfia vomitoria. We discussed sometime ago the fact that Syrosingopine is related to this products https://www.cancertreatmentsresearch.com/community/metabolic-inhibitors/combo-metformin-and-syrosingopine-looks-awesome/#post-856
                   I checked my e-mail and indeed there was somebody using some of Beljanski products but it did not specifically helped to my knowledge. Of course, this is only one “data point”.
                   I do not know anyone who used Postabel.

                   Kind regards,
                   Daniel

                2. Hi Shanti, I don’t know anyone who has used it.

                3. Hi D- Great connection between the rauwolfia and vomitoria and Syrosingopine. Thanks for this info. I have set up a professional account with Beljanski Products and may set up a consult with someone on their clinical team to see if they can provide any additional info or case studies.
                   -Shanti

                4. Shanti,
                   I tried Prostabel for a number of months, and saw no decrease in my cancer markers or tumor sizes. I have had non-metastatic Pca for nearly 10 years now, PSA runs between 10 and 15 all the time, and I use nagalase test for gauging cancer activity level. Have had two PET scans, a number of MRI scans, and many ultrasounds. Been to Germany three times for local hyperthermia treatment at Klinic Marinus am Stein (which closed permanently due to loss of patients from USA during the pandemic).

                   The regimen I’ve been on the last couple of years has been Dr Rath’s Healthy Cell Synergy, Sanjevani Bosmeric-SR, cod liver oil, Vit D 10,000 IU or preferably sunbathing, melatonin 100mg, liposomal vit C, and once every two weeks 50g Vit C IV. If I miss my IV-vitC, I notice nagalase reading goes up. I don’t miss those anymore!

                   One piece of information about prostate cancer that to me is extremely important is this: Prostate glands filter heavy metals out of the prostatic fluid made by the gland over the man’s life. This is evidenced by a small sampling of six men’s prostates which were surgically removed, during which samples of the tissues outside the prostate gland were sampled and sent along to an environmental testing laboratory. The results were that ALL six men had heavy metal contamination inside their prostates, and the level of this internal contamination was on average about 400 times the level of contamination of the surrounding tissue outside the prostate.

                   This to me is evidence of a big problem, realizing that heavy metals in proximity to local infections are a driver towards carcinogenicity in these tissues. Most men have tiny infections in their prostates, from what I’ve read. And in today’s world, we are all exposed to heavy metals. The concentration issue only makes it worse (well, it does protect the DNA of the next generation, but at a cost to the father.)

                   From my experience, PSA numbers can be caused by prostate cell crowding( due to gland enlargement or tumor growth), or infections in the prostate (which I have had and probably continue to have, despite the best treatments to eradicate them (but medical science has not found a way to remove the biofilms that protect the bacteria in the prostate from ANY and ALL antibiotics)).

                   I believe that successful management, if not elimination, of prostate cancer lies in (1) addressing the removal of the heavy metals in the gland, and (2) addressing the infection (and resultant inflammation) in the gland, and (3) introducing cytotoxic materials to reduce or eliminate the tumor(s), and (4) preventing the metastasis of the prostate cancer circulating tumor cells/stem cells.

                   I pray for your husband’s healing, and thank you for all the devotion in support of him during his trial. You are a huge blessing.

                   Yours, in Christ,
                   Harry

                5. @Harry W

                   Thank you for sharing your experience. We never did try the Prostabel or any of the Beljanski products. The research just wasn’t convincing enough for the high price. Thank you for sharing your additional thoughts. They don’t apply so much to my husband as he had his prostate removed in Jan of 2017 (he has stage IV), but I’m sure others reading this forum will find your comments and observations useful.
                   My husband is on medication, but still in remission with a PSA<0.04.

    2. HI Shanti,

       It’s always so nice to hear from you! Have you already included plant sterols and SDG (flax seed extract)?
       These should have relevant contribution in prostate cancer.

       Kind regards,
       Daniel

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       1. Hi D!
          So thoughtful of you to take the time to say hi and add some suggestions. I posted above our latest PSA, which did not go up from last month. We now have 3 months (non-consecutive) documented where PSA does not increase when we use clioquinol with high dose zinc (my husband is off all conventional therapies). Other months it increases by 50%. We are going to try to keep the PSA under 1 using this method until we can travel for the PSMA scan and Lu-177 treatment. Amazingly, we only have to use the clioquinol cream for 1 week out of 4 to get these results. Its use amounts to my husband feeling poorly for a 1.5 weeks, which he agrees is a good trade-off.

          To answer your question, we have used SDG flaxseed lignans in high dose, but the only plant sterols we have used were in the Prostasal blend, which caused breast tenderness and my husband felt like he was on the estrogen patch (which we had tried at one point to control hot flashes / bone density). I think I mentioned that I have some suspicions that Prostasal is spiked with some sort of estrogen based on his experience and other reports and its connection with PC-Spes. Anyhow, I can try some plant sterols since Prostasal was not a fair trial. Thinking to get a high dose beta-sitosterol, unless you have one you suggest in particular.
          Hope you are happy and healthy,
          Shanti

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          1. Hi Shanti,

             Thanks a lot for your response and again very nice to hear from you!
             Great to hear about the positive results with Zinc and Clioquinol!
             Yes, you indeed mentioned about that supplement and the estrogen like effects. And the same kind of response was reported by other people. Indeed beta-sitosterol as stand alone may be helpful but I have no preferred one at this point. Could you please let me know what is your opinion on SDG now after using it, and how high was the dose you used/day? Thank you.

             Kind regards,
             Daniel

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             1. Hi D,
                This is the brand we have used, Lignans For Life:
                https://www.lignans.net/lignans-for-life-products.html
                We have used the HMR lignans 40mg, but I can’t remember the dose, I think 4 per day and we used the SDG flax lignans 4-6 per day. My husband also often adds flax seeds to his smoothies. He took it during the time he was in NED, so we actually don’t know if it had an effect or not, but he did tolerate it fine. It is something I would consider adding back, but at the moment, my husband is saying ‘no changes’ just mimic what we did last month.

                Of course, lignans are part of many prostate formulas and their mechanisms of action make sense, but I have no experience with them as a single agent where I was able to observe an effect. I think that inhibiting 5-a-reductase, and thus, DHT formation is an important part of a strategy against prostate cancer. Unfortunately, many men (and their doctors) who were on 5a-reductase inhibitors did not realize that the medications decrease PSA by about 50%, so many prostate cancers were missed and only caught later when more aggressive. This in part gave rise to the scare that these medications lead to more aggressive prostate cancer. I think the long term data has proven that there is no increase in mortality in men on these meds, and likely a benefit: https://www.jwatch.org/na47972/2018/12/06/revisiting-prostate-cancer-risk-with-finasteride-and. I am of the opinion that, once diagnosed, there are benefits in blocking DHT, either as part of an overall androgen blockade or as a stand-alone therapy. Lignans share the mechanism of finasteride/dutasteride, but aren’t as strong in their inhibition of 5a-reductase, but, as you know, they may have benefits in addition to the 5a-reductase inhibition. If you have any experience with them, I would certainly be interested to hear.
                Warmly,
                Shanti

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                1. Hi Shanti,

                   Thank you for your response. Indeed I think SDG makes very much sense but I also think that it’s best to continue what you are doing without changes at this point.

                   I do not have any direct experience with SDG, but I like the potential impact on health as indicated by literature, in oncology but also in general. I was actually some days ago looking at Prostaol supplement and this is what triggered me to look in SDG. I am thinking that due to it’s potential benefits it could make sense to have if as a pat of the supplement range at MCS Formulas. But probably in a higher dose, maybe 100mg SDG/capsule. I will continue to investigate this closer and let you know if I find anything else.

                   Kind regards,
                   Daniel

             2. Making a higher dose lignan product makes sense since people often under-dose cancer-targeted nutrients.

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                1. Thank you for sharing your view on this one dear Shanti!

                2. Hola Shanti! I believe you can get a high lignan product by cold pressing you own flax seeds to obtain flax seed oil plus lignan… the cold pressing machine is not that expensive and that way you know you will consume a great quality product

                3. That is an interesting thought. Do you think it has an advantage to grinding the seeds and adding the ground seeds to food and smoothies?

                4. When you cold press the flax seeds to obtain the oil you get the ground flax seed, the oil and the lignans, they look like a brownish thing in the bottom of the bottle. I believe you will get a more fresh, better quality high lignan flax seed oil. I make my own flax seed oil.. Plus, being so fresh it has the nutty flavor described by Dr. Budwig

    3. Hello Shanti,

       Thank you for all the detailed info about treatments for your husband’s prostate cancer. My husband is also dealing with Stage IV prostate cancer for the past 2+ years. I”m curious what the strength was for the clioquinol cream? Is there a reason he was only using it for a few days a month? Thanks.

       warmly,
       Aiyana

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26. Hi Friends,
    My husband has been off of ADT for almost two years on a “vacation”. Our plan was to travel to Germany for radioligand therapy with Lu-177 PSMA once his PSA hit 1. To check to see if he is a candidate for this therapy we first traveled to UCLA for a Ga-68 PSMA PET/CT scan. This scan is expected to obtain FDA approval in the fall and is currently the most sensitive scan for prostate cancer.
    Although the scan showed 4 bone lesions that were PSMA avid, the high-resolution CT picked up some questionable lung and liver spots that were not PSMA avid. Without out knowing what these spots are, and knowing that, if they are cancer, they will not respond to Lu-177 treatment, we canceled our Germany trip. My husband is now back on ADT/Zytiga and we are monitoring the lesions for change in size.

    During his time off ADT, the thing we found most effective for slowing and even decreasing PSA was clioquinol cream with high dose zinc. We have four months documented where this decreased, slowed or plateaued his his PSA. We used it too little too late, but if my husband is able to take an ADT break again in the future, we will use it early and hopefully extend his time off the meds.
    I just wanted to provide an update since some of you had asked to let you know how this all worked out.
    Wishing the best for each of you,
    Shanti

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    1. HI dear Shanti,

       Thank you so much for the update and for sharing your positive findings with clioquinol cream.
       (I am looking forward to soon finish with the start-up of the supplement company and be able to start allocating time again to consolidating information on treating options, to help with more ideas.)
       Are you continuing with the supplements and repurposed drugs you are using, or deciding to stop anything?

       Kind regards,
       Daniel

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       1. Hi D,
          Good question. We have stopped almost everything for the moment as my husband wanted to take a break while under the protection of the ADT. ADT was extremely effective for him last time, dropping PSA to <0.006 for two years even though he only took it for one. We are hoping for another good response. We will take this time to re-think our strategy and if we want to use the clioquinol while he is on ADT or start it again if and when he takes his next break, and what else we may want to add to it. We are always open to suggestions.
          Warmly,
          Shanti

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    2. Hi Shanti,
       thanks for the feedback on the clioquinol + high dose zinc. How much zn is he on?
       Have you considered (high dose) melatonin?
       https://www.researchgate.net/publication/8335434_Melatonin_reduces_prostate_cancer_cell_growth_leading_to_neuroendocrine_differentiation_via_a_receptor_and_PKA_independent_mechanism

       Nobiletin:
       https://pubs.rsc.org/en/Content/ArticleLanding/2020/RA/C9RA10020B#!divAbstract

       Regards

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       1. We used 150mg zinc per day, just during and around the days that he used the cream, which was 3-5 days out of the month. He would feel poorly during that time, but he is very sensitive to medications. My understanding is that most people tolerate the cream just fine.

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       2. We did try melatonin, never got to high dose as even the lower doses caused grogginess the entirety of the next day. Maybe I could start him with a very low mcg dose and slowly work up.

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          1. I get this grogginess to, but it’s not worse if i take 10mg instead of 3mg, i do get more vivid dreams with the higher dose.

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             1. Thanks Johan, we will be reconsidering/trying melatonin as well as we restrategize.

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       3. Thank you for the link with the info on Nobiletin. We are going to be rethinking our anti-cancer strategy and will consider this.

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    3. Did you use the clioquinol in genital area or intrarectally? Saludos!

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       1. Actually, we used it on the inner elbow and back of knee. The molecular weight is low enough that it gets absorbed. At home I have info on the % absorption as it has been studied. Genital/rectal application would increase absorption even more, as would adding DMSO.

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    4. Hi Shanti,
       Im new to this website and have found it has provided much more information on tackling cancer from the patients ability in comparison to others. I was wondering what your updated protocol for your husband currently is? Or what you would suggest in terms of supplements / dosages.
       My mom is a stage 4 non small cell lung cancer patient and we have been told to start on chemo soon but have been reserved to doing so as her weight has already dropped tremendously from using targeted treatment therapies the past 2 years as well as weakened her hearts extraction rate. We’re looking to incorporate more natural protocols and add-ons in terms of supplements and have already done so, but as I’m reading through this website, I noted combinations of supplementations in how they absorb in the body is vital. We don’t want to make errors in combinations of these supplements and their recommended dosage.
       So many things I’m reading are a bit confusing in terms of technicality, so any recommendations on at least a good list to start in vitamins / supplements and dosage would be so tremendously helpful.
       I hope you continue to hear good news with your husbands health. It’s a journey but it gives us hope!

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       1. Hi-
          I’m sorry to hear about your mom, but welcome to this forum. There is a wealth of information here. If you scroll down, this page serves as a table of contents of sorts: https://www.cancertreatmentsresearch.com/summary-of-this-website/. The protocol I put together for my husband was really tailored to Prostate Cancer, although most of what we used is anti-cancer in general. Unfortunately, my husband is extremely sensitive to medications and some supplements, so we were not able to implement everything I would have liked. Nonetheless, we did find that the combination of Clioquinol and zinc did seem to inhibit my husband’s cancer. Although this combo may help other cancers, prostate cancer, in particular, has highly altered zinc metabolism, which could be an ‘Achilles heal’ so to speak. Many people looking to use off-label meds start with the Care Oncology Protocol, especially since you can work with Care Oncology to get the medications prescribed: https://www.cancertreatmentsresearch.com/drug-cocktail-that-could-double-the-average-survival-time/?highlight=care%20oncology. Then people often add on from there. As far as supplements go, there is generally very little concern for toxicity. The main concern is making sure that your supplement isn’t working against any conventional treatments or medications you are using, you can take a look here to see what I mean: https://www.cancertreatmentsresearch.com/modulating-the-yin-and-yang-energy-of-cells-to-fight-cancer-pro-oxidant-strategy/.

          When it comes to supplements with quality and potency in dosing, there is no company I trust more than MCS formulas, which was started by Daniel (the owner of this site) and his business partner: https://www.mcsformulas.com/. I would certainly consider supplements like melatonin (20mg-50mg), Curcumin, green tea, pectasol and getting enough vitamin D so that blood levels are between 50-80ng/mL. Here is another article may find useful to orient you to supplement use in Lung Cancer: https://www.lifeextension.com/protocols/cancer/lung-cancer.

          I hope that helps!

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          1. Thank you so much for this information. I have, since your post, incorporated a lot of integrative medicine, including supplements from this site for my moms protocol. We are hoping for positive results. I hope your husband is doing well and again, it’s great to find people like yourself that put so much passion in learning about alternative medicines for this horrible disease. As a fellow caregiver, your dedication is inspiring. Thanks again.

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27. Hello everyone. I began to frequent this site due to my mom’s ST IV BC diagnosis. Yesterday my father was diagnosed with prostate cancer, my head is in a whirl.
    Gleason 3 + 3
    PSA 8.7
    He will be subjected to a radical prostatectomy within a week or so.
    I would greatly appreciate input regarding pre and post operative care and supplementation, and any advice in general. Thank you

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    1. Hi jshaw,
       I’m sorry to hear about your dad’s diagnosis. Gleason 3+3, or 6 is the lowest Gleason score you can have, in fact there is strong evidence that Gleason 6 almost never directly moves into aggressive cancer requiring treatment, so I am surprised to hear that a radical prostatectomy is being suggested this coming week…… do you know how many cores are positive? I would strongly suggest getting a second opinion from both a Medical Oncologist and a Radiologist, especially if it is a Urologist making this suggestion, and even more so if the same person making the suggestion is also doing the surgery, as they stand to gain a great deal financially. If this is Gleason 6, there is no reason any treatment needs to be rushed into. If Gleason 6 even requires treatment, it can often be managed with brachytherapy alone and/or SBRT, resulting in minimal side effects and preserving sexual and urological function. Here are some articles on Gleason 6:
       https://ascopost.com/issues/july-25-2018/when-can-patients-with-gleason-6-prostate-cancer-safely-undergo-active-surveillance/
       http://paact.help/gleason-336-its-the-best-biopsy-gleason-score-you-can-have/
       https://www.prostatecancer.news/search/label/GS%206
       https://www.cancernetwork.com/view/gleason-6-prostate-cancer-serious-malignancy-or-toothless-lion

       If he does move forward with the prostatectomy, consider cimetidine (https://www.lifeextension.com/magazine/2007/5/report_cimetidine), Pectasol (https://www.lifeextension.com/magazine/2011/7/novel-citrus-extract-blocks-deadly-cancer-cell-signaling) and using nutrients to support the immune system around the time of the surgery.
       Wishing you and your family the best.

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       1. Hello Shanti, thank you very much for your reply. I am clueless about prostate cancer, mostly having read about BC
          3 out of 12 cores were positive. Following your advice, we will be seeking a second opinion from a medical oncologist on Tuesday and also plan an appointment with a radiologist. I will look into acquiring both cimetidine and the citrus extract.
          Kind regards

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          1. Glad to hear you will be getting a second opinion. Take the time to educate yourself and make an informed decision. Gleason 6 in 3 cores does not require urgent action. Take care! – Shanti

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28. Hello all,

    I’m finding this thread and this whole website really helpful as I research alternative treatment options for my husband who is dealing with Stage IV prostate cancer. One question: where do you all recommend getting off-label drugs such as metformin, doxy, etc? Is there a way to obtain these online without a prescription? I’m sure I could find this info if I dig further into this site, but just thought I’d start by asking here.

    Many thanks.

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    1. Hi,

       I am glad you find this website helpful. Here there is a list of some online pharmacies where people are ordering their drugs https://www.cancertreatmentsresearch.com/suppliers/ For Metformin, another option is to contact COC clinic. In that case you need to pay a consultancy fee, and they would help with the drugs. Nevertheless, the cheapest way to access drugs like Metformin is still via online pharmacies.

       Kind regards,
       Daniel

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       1. Hello Daniel,

          Thank you for that link. That’s most helpful.

          warmly,
          Aiyana

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29. A lot to take in and try to research but will try eventually to do so. What is your opinion of switching up Metformin and berberine as I only take 500mg 1x/day but try to switch out (maybe 5 days to 2 M:B) to minimize any adverse effects and to get the other advantages of berberine?

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    1. Dear Bigbird,

       I do not understand well your question. Could you please reformulate? Thank you.

       Kind regards,
       Daniel

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       1. To clarify, my ex-functional medicine dr put me on 500mg/day of metformin; I take it 4-5 days/wk but switch out with Enzymatica’s berberine capsules 3/day 2-3 days/week. Increase the metformin and no dr to prescribe a change in dosage or will berberine work nearly or as well?

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          1. Hi BigBird,

             Thanks for clarifying.

             In some Asian countries, Berberine is seen as a drug used to achieve similar results as Metformin. However, natural extracts are more difficult to be absorbed compared to drugs that have been optimized for that.

             One specific issue with Berberine is that it needs to be converted by a specific gut bacteria in order to be absorbed https://www.nature.com/articles/srep12155 On the other hand, the gut bacteria are strongly affected in patients that went on antibiotics, chemo or other heavy drugs.

             This is the challenge with switching completely to Berberine. It may or it may not do its job from person to person.

             As a side note, MCS Formulas tried to address this issue and reduce the need for gut-bacteria support, with a pro-liposomal form of Berberine.

             Otherwise, I would say that to minimize adverse effects from Metformin, it can be taken with food, or alternatively, there is a light version – a slow release version that is much more friendly.

             I hope this helps.

             Kind regards,
             Daniel

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             1. Ok, thanks.

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                1. BTW, I only take …for now, Proscar, Metformin, Losartan, Hydrochlorothiazide, and Flowmax along with an ADT shot.

30. I guess you could.

    BTW, here’s an interesting combination:

    Metformin combined with quercetin synergistically repressed prostate cancer cells via inhibition of VEGF/PI3K/Akt signaling pathway

    https://pubmed.ncbi.nlm.nih.gov/29678660/

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    1. I take the aforementioned and Life Extension’s quercetin & C combo. Thanks, will read that.

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31. در میان بیماران با ویژگی‌های پاتولوژیک پرخطر پس از پروستاتکتومی رادیکال برای سرطان پروستات، استفاده کمکی 1 ساله از آتورواستاتین با خطر کمتر عود بیماری در مقایسه با دارونما همراه نبود!

    https://pubmed.ncbi.nlm.nih.gov/34011557

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32. PCaLiStDB is the first database focus on a specific disease related lifestyles. It integrates possible lifestyles and lifestyle-related factors included foods, nutrients, habits, social factors, environment, associated genes, physiological and biochemical indexes together with the corresponding diseases or drugs. It provides a Lifestyle-Wide Association Studies of PCa (PCa_LWAS), seeking to identify the systematic and deep-seated studies between lifestyles and PCa, and to study the profound benefits achievable with lifestyle changes and to tell people “what to do”, “how to do” and to continue developing ways to encourage choices that promote human health.
    The ultimate goal is to accelerate the translation of LWAS discoveries into results that are closer to clinical applications, to obtain the accurate predictive models for prostate cancer prevention based on evidence-based personalized lifestyle-related data.

    http://www.sysbio.org.cn/pcalistdb/protective.php?&page=all

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33. Geranylgeraniol suppresses the viability of human DU145 prostate carcinoma cells and the level of HMG CoA reductase
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4010193/

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34. Bromhexine
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4409786/

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35. Hello everybody,
    could anybody provide me information how relevant is to focus on glutamine pathways in early stage of the disease? Just started MCS Glutamine inhibifour. No confirmed metastasis so far, PSA during almost one year – the highest one 6,2 the lowest 4,14. We are going up an down. After the initial chaos it is time to know what we are doing finally to achieve the desired effect. No chemo, radiation, so far. Biopsy Gleason 8 (not very good). Forced to undergo an operation.
    Thank you.

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    1. Hi, I’d go through all the posts by Shanti, I think her husband´s prostate cancer is Gleason 8 or 9 and they have been very successful at controlling the disease.
       https://www.cancertreatmentsresearch.com/participant/shanti/

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       1. Yes, I have read several her posts under articles several times and see them very usefull, nevertheles I think there are some differences. My husband is 53, I’m not sure if I think in a correct way, we should focus on adrenal point. He takes nothing for androgen deprivation so we have to count with this.
          Now he takes a lot of things. For fat pathways he has lycopene, citrus bergamot (added only lately), garsinia+ALA, tocotrienol+tocoferols, betulinic acid, danshen, niacin, xanthohumol, omega3, milk thistle. Others – EGCG, berberine, black seed, cbd, curcumin, resveratrol, feverfew (Once daily), magnesium gluconate (twice), glutamine inhibifour (just incorporated), sulforafan, melatonin, mushrooms, metformin (just a few days), vitamin D, A, aspirin, and now artemisin (during 3 weeks several days on and off). Pyrvinium ordered. Zn ionophore has just arrived. He took Ivermectin also but we have not reached the desired effect, I have realized bergamot was needed too. Honokiol just arrived. I’m not sure if it is all. Yes, serrapeptase, pectasol, tudca ( he was on fenben too ).
          So he has a lot of things maybe too much.
          Thank you for the link, I will also check other posts of Shanti.

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          1. You say his PSA is going up and down, but is it trending lower?

             There’s a link to my blog if you click on my username above, there’s a list of supplements with a focus on synergistic combinations.

             Dosage is another issue, and that’s why the synergies can be very helpful as reduced amounts are needed to obtain an anticancer effect.

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             1. Thank you Johan for reaction.
                PSA fluctuates because we had little or no idea what we were doing. We knew nothing about the disease and my brain refused to think. It was shock, then overwhelmed by amount of information.
                At first we tried combo – soda, Ivermectin, fenbendezole, IV vit C from vevirology, the first thing that came to our hands. It was just after biopsy, before which PSA was 6,2. After 4 weeks around 5,5. The doctor was quite shocked, because operation was the only option. We then went to veterinary Fenbendezole – low dose, essiac, omega, some curcumin, vit.D, artemisin tincture. PSA remained the same so we increased the dose of Fenb. and the tea some vitamins including b complex. PSA went to 4,5, so we were happy we were on the right track but we were not. We continued, PSA rose 4,83. I realized something about pathways facts, of course understanding very poor or zero. Number of supplements added. We added IVM. Last PSA was 5,36. Just a few last days I have been able to think more consistently, perhaps some understanding occures 🙂 I took some rhodiola, it seems it helped me a bit.
                So, no surprise PSA goes up and down.

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                1. In PC one needs to be careful with B-complex supplementation, these often contain high amounts of B12 and folate.
                   Control of prostate cancer associated with withdrawal of a supplement containing folic acid, L-methyltetrahydrofolate, and vitamin B12: a case report
                   https://jmedicalcasereports.biomedcentral.com/articles/10.1186/1752-1947-5-413

             2. We have made changes in diet too. Some period he was addicted to bacon…I felt something was wrong.

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                1. I like bacon but I wouldn’t eat it if I had PC.

                   Fatty Acid Inhibition Sensitizes Androgen-Dependent and -Independent Prostate Cancer to Radiotherapy via FASN/NF-κB Pathway

                   “Orlistat treatment significantly reduced the S phase population in both androgen-dependent and -independent prostate cancer cells. Combination of orlistat and RT significantly decreased NF-κB activity and related downstream proteins in both prostate cancer cells”
                   https://www.nature.com/articles/s41598-019-49486-2

                   Duke Scientists Uncover Ferroptosis as a Potential “Achilles Heel” in RB1-Deficient Prostate Cancer
                   https://pathology.duke.edu/news/duke-scientists-ferroptosis-rb1-deficient-prostate-cancer

             3. B complex was excluded, than added because of unending cold sore. Could L-lysine be used to treat cold sores?

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                1. yes, but probably best just a low dose of 300mg, I wouldn’t take more. Rosemary might help also. And gelatin. You can add a little gelatin powder to a cup of tea.

36. Tomato-broccoli together shown to be effective against prostate cancer
    https://news.illinois.edu/view/6367/211101

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    1. Thank you very much Johan! We will try to continue with the new things then. We will see what happens.
       Perhaps he might be given some radhioteraphy if the numbers were favourable.
       Have a nice weekend!

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       1. best of luck!

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          1. Thanks a lot 🙂

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    2. Prediction of Synergistic Drug Combinations for Prostate Cancer by Transcriptomic and Network Characteristics
       https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8112211/

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37. I would like to know if it would be worth to make some suppositories from pyrvinium with regards to necessity to use some coconut oil and oils should be avoided in case of prostate cancer.

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