@manuone About the BBB and GBM, this article may explain better, that while the BBB can be disrupted in GBM, there always are regions of the tumor wit...
@manuone AFAIK in order to be effective against brain cancer, a drug must be able to cross the BBB. While looking into anti-angiogenic therapy for GBM...
@manuone I'm sorry, I must have mis-remembered about the biovailability of Calcium Dobesilate, from 7 years ago. It appears that it's orally well abso...
@manuone Dobesilate has poor biovailability at commonly used doses, and may prove too hepato-toxic at higher doses. However, if it reaches the tumor, ...
This research is promising, but there are some issues: - they only test on the MCF-7 line (only one, when so many are possible), and in vitro (no mous...
Plain DSF is of very limited use against cancer, in vivo, because most of the activity is lost by the metabolites. The current research tries to deliv...
Interesting, but the patient had to tolerate a huge amount of herbal extracts, and for a long time. If I counted correctly, 282 grams / day!!! Boiling...
Avoid Digoxin, at least in combination with Quercetin or Pgp inhibitors (like Disulfiram metabolites, Itraconazole, etc), this has been known for a lo...