ovidiu
@ovidiu
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RE: Fibroblast Growth Factor Receptor Functions in Glioblastoma

@manuone About the BBB and GBM, this article may explain better, that while the BBB can be disrupted in GBM, there always are regions of the tumor wit...

4 years ago
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RE: Fibroblast Growth Factor Receptor Functions in Glioblastoma

@manuone AFAIK in order to be effective against brain cancer, a drug must be able to cross the BBB. While looking into anti-angiogenic therapy for GBM...

4 years ago
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RE: Fibroblast Growth Factor Receptor Functions in Glioblastoma

@manuone I'm sorry, I must have mis-remembered about the biovailability of Calcium Dobesilate, from 7 years ago. It appears that it's orally well abso...

4 years ago
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RE: Fibroblast Growth Factor Receptor Functions in Glioblastoma

@manuone Dobesilate has poor biovailability at commonly used doses, and may prove too hepato-toxic at higher doses. However, if it reaches the tumor, ...

4 years ago
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RE: Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)

This research is promising, but there are some issues: - they only test on the MCF-7 line (only one, when so many are possible), and in vitro (no mous...

5 years ago
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RE: DIsulfiram Updates?

Plain DSF is of very limited use against cancer, in vivo, because most of the activity is lost by the metabolites. The current research tries to deliv...

5 years ago
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RE: A Case of Recurrent Hepatocellular Carcinoma Acquiring Complete Remission of Target Lesion With Treatment With Traditional Chinese Medicine

Interesting, but the patient had to tolerate a huge amount of herbal extracts, and for a long time. If I counted correctly, 282 grams / day!!! Boiling...

5 years ago
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RE: Drug Repositioning for Effective Prostate Cancer Treatment

Avoid Digoxin, at least in combination with Quercetin or Pgp inhibitors (like Disulfiram metabolites, Itraconazole, etc), this has been known for a lo...

6 years ago