MichalH
MichalH
@michalh
Topics: 0 / Replies: 15
Reply
RE: Re-puporsed drugs to treat NSCLC, ROS1-positive

dng050, I started the silibinin thread on cancergrace and inspire (where I am as daxys). I communicated with dr. Bosch-Barrera and my mum has been ta...

3 years ago
Reply
RE: Re-puporsed drugs to treat NSCLC, ROS1-positive

Is entrectinib used more widely in some cancers ? If so (or even if not), you can ask other patients on forums for leftovers of entrectinib. Some peop...

3 years ago
Reply
RE: Re-puporsed drugs to treat NSCLC, ROS1-positive

dng, thank you for your clarification. Intermittent low dose crizotinib seems to me a good strategy for now. Maybe you will find a way to rechalleng...

3 years ago
Reply
RE: Re-puporsed drugs to treat NSCLC, ROS1-positive

Hi dng, It seems these two TKIs are really new, therefore no generics available yet. I dont have much experience with ROS mutations. My mum has EGF...

3 years ago
Reply
RE: Re-puporsed drugs to treat NSCLC, ROS1-positive

Dear dng050 If you cant get another TKI approved but you know it should be effective for your brother’s current mutation or just want to try it, yo...

3 years ago
Reply
RE: Fast-growing tumors (lung ..) - any salvage therapy to try ?

Thank you both for your replies and links. Some of them I know already, some are new. Mum has already tried taking fenbendazole, maybe we should do it...

3 years ago
Reply
RE: Fast-growing tumors (lung ..) - any salvage therapy to try ?

By salvage therapy I mean something to try with some chance that it would work. We have mifepristone for about a month that we are going to try, but ...

3 years ago
Reply
RE: How fast can cancer adjust (metabolically) to repurposed drugs ?

@johan thank you Johan. Sorry for the delay in my response, I have been rather busy recently in these turbulent days and also mum has pneumonia, so ...

3 years ago
Reply
RE: How fast can cancer adjust (metabolically) to repurposed drugs ?

Thanks a lot to all of you for your replies! So it seems that metabolic adjustment could be pretty fast (a couple of days) whereas resistance caused ...

3 years ago
Reply
RE: How fast can cancer adjust (metabolically) to repurposed drugs ?

What do you think how long it takes for cancer to chance its metabolism? They say (Jane McLelland) that if you block glucose then cancer switches to g...

3 years ago
Reply
RE: How fast can cancer adjust (metabolically) to repurposed drugs ?

@daniel Hi Daniel, thank you, I knew you said it is difficult to block all pathways in your earlier article and it is definitely the case for my mum.

3 years ago
Reply
RE: How fast can cancer adjust (metabolically) to repurposed drugs ?

I wanted to write a longer post, but somehow posted it and it seems it cannot be edited - so here it is again: There is a lot of talk about starvin...

3 years ago