@daniel Thank you! The chemo is interrupted in the middle and i am afraid that i need to gain time before next cycle, otherwise patient will run i...
@daniel Hi Daniel Thank you, appreciate for your help! - PD/PDL1 should be assessed and administered by knowledgeable MD and i guess in combinat...
@daniel Dear Daniel. Thank you for your opinions. I had seen this thesis and researched few options from there as: - BCL inhibition with plant ...
@johan Dear Johan, thank you for your suggestion. I had to administer it 2 months ago but couldn't due to disrupted supply chain because of covid. ...
Hi Daniel Thanks for taking time and answering question. Is it feasible to add kidney function eGFR as well? I had a look to LDH values and th...
BTW, there is a presentation paper from Riordan clinics for high dose Melatonin treatment: High Dose Melatonin Therapy - An Ideal Adjuvant Anti-canc...
Thanks Johan for this article. had a look to another article referenced from there - oral doses from 10mg to 40mg was used: Melatonin as Adjuvant...
@michalh Sorry to hear about your mother condition. I think, in addition to metabolic therapy, you could also investigate approaches that could result...
@dng050, Daniel may answer this precisely. from what i know, you shouldn't try to add something on top of current treatment : before your curren...
@mkk yes, i see. researched Spain before for treatment - iirc you have largest number of Sarcoma Centers in Europe. i tried to contact endocrynol...
My error - V2R agonist dDAVP is actually desmopressin. So previous article pointed to the increase in tumor growth upon its administration. So be caut...
Intracranial desmoplastic small round cell tumor presenting as a suprasellar mass A 27-year-old man was referred to the endocrinology clinic with...
@mkk Do you have a chance to investigate 2 posts i made on hormones: There is a chance these 2 could be valid therapeutic points to consider...
@daniel Hi Daniel Thank you for reply. I feel incompetent to deal with it as it requires time (which is i am short of) to educate myself on human ...
A patient with Ewing's sarcoma presented with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) (1). Plasma values for vasopress...
Combining Desmopressin and Docetaxel for the Treatment of Castration-Resistant Prostate Cancer in an Orthotopic Model Desmopressin is a synthetic...
Hi Nguyen, really sorry for this. Achievable complete remission of advanced non-small-cell lung cancer: Case report and review of the literatureBro...
Johan mentioned good starting dose. If your MD will find this drug relevant (from anti-tumor perspective) you may be asked to do drug titration to fin...
@jpizzuto It is hard for me to answer that (i am not MD). As i can't assess risk of bleeding and other complications, it would be good if surgeon ...
imho, before raising consent, the second opinion from another surgeon, stating necessity of nsaid administration and operation risk assessment must be...
@mkk you may ask your doctor whether foxm1 directed therapy is eligible for this type of sarcoma: FOXM1 in sarcoma: role in cell cycle, pluripotency...
valproate, probably less potent, is cheaper alternative to HDACi drugs in above article.
Histone deacetylase inhibitors vorinostat and panobinostat induce G1 cell cycle arrest and apoptosis in multidrug resistant sarcoma cell lines In th...
Hi Johan Thank you for reminding that. I completely forgot the point that EGCG and other catechins degrade in alkaline environment. The relation b...
@mkk for colloidal silver therapy you might be interested in nanoparticles that specifically designed to be absorbed by tumor cells. E.g./p> this ar...
Hi Daniel To be precise: patient has a history of allergy to contrast agent. All previous MR scans where contrast agents used resulted in tempora...
for cic-dux4 mouse tests with dinaciclib show growth suppression: but drug isn't approved yet. may be you could check for ongoing trials if there...