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Topics: 0 / Replies: 82
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RE: Biomarkers for treatment efficacy evaluation

@daniel Thank you! The chemo is interrupted in the middle and i am afraid that i need to gain time before next cycle, otherwise patient will run i...

2 years ago
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RE: Biomarkers for treatment efficacy evaluation

@daniel Hi Daniel Thank you, appreciate for your help! - PD/PDL1 should be assessed and administered by knowledgeable MD and i guess in combinat...

2 years ago
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RE: Biomarkers for treatment efficacy evaluation

@daniel Dear Daniel. Thank you for your opinions. I had seen this thesis and researched few options from there as: - BCL inhibition with plant ...

2 years ago
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RE: Biomarkers for treatment efficacy evaluation

@johan Dear Johan, thank you for your suggestion. I had to administer it 2 months ago but couldn't due to disrupted supply chain because of covid. ...

2 years ago
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RE: Biomarkers for treatment efficacy evaluation

Hi Daniel Thanks for taking time and answering question. Is it feasible to add kidney function eGFR as well? I had a look to LDH values and th...

2 years ago
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RE: "Melatonin and non-small cell lung cancer: new insights into signaling pathways"

BTW, there is a presentation paper from Riordan clinics for high dose Melatonin treatment: High Dose Melatonin Therapy - An Ideal Adjuvant Anti-canc...

2 years ago
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RE: "Melatonin and non-small cell lung cancer: new insights into signaling pathways"

Thanks Johan for this article. had a look to another article referenced from there - oral doses from 10mg to 40mg was used: Melatonin as Adjuvant...

2 years ago
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RE: Fast-growing tumors (lung ..) - any salvage therapy to try ?

@michalh Sorry to hear about your mother condition. I think, in addition to metabolic therapy, you could also investigate approaches that could result...

2 years ago
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RE: Re-puporsed drugs to treat NSCLC, ROS1-positive

@dng050, Daniel may answer this precisely. from what i know, you shouldn't try to add something on top of current treatment : before your curren...

2 years ago
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RE: Treatment protocol sarcoma with mets

@mkk yes, i see. researched Spain before for treatment - iirc you have largest number of Sarcoma Centers in Europe. i tried to contact endocrynol...

2 years ago
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RE: Desmopressin

My error - V2R agonist dDAVP is actually desmopressin. So previous article pointed to the increase in tumor growth upon its administration. So be caut...

2 years ago
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RE: Desmopressin

Intracranial desmoplastic small round cell tumor presenting as a suprasellar mass A 27-year-old man was referred to the endocrinology clinic with...

2 years ago
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RE: Treatment protocol sarcoma with mets

@mkk Do you have a chance to investigate 2 posts i made on hormones: There is a chance these 2 could be valid therapeutic points to consider...

2 years ago
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RE: Desmopressin

@daniel Hi Daniel Thank you for reply. I feel incompetent to deal with it as it requires time (which is i am short of) to educate myself on human ...

2 years ago
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RE: Desmopressin

A patient with Ewing's sarcoma presented with the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) (1). Plasma values for vasopress...

2 years ago
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RE: Desmopressin

Combining Desmopressin and Docetaxel for the Treatment of Castration-Resistant Prostate Cancer in an Orthotopic Model Desmopressin is a synthetic...

2 years ago
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2 years ago
Replies: 7
Views: 577
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RE: Re-puporsed drugs to treat NSCLC, ROS1-positive

Hi Nguyen, really sorry for this. Achievable complete remission of advanced non-small-cell lung cancer: Case report and review of the literatureBro...

2 years ago
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RE: Treatment protocol sarcoma with mets

Johan mentioned good starting dose. If your MD will find this drug relevant (from anti-tumor perspective) you may be asked to do drug titration to fin...

2 years ago
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RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!

@jpizzuto It is hard for me to answer that (i am not MD). As i can't assess risk of bleeding and other complications, it would be good if surgeon ...

2 years ago
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RE: Combo Metformin And Syrosingopine!!!! Looks Awesome!

imho, before raising consent, the second opinion from another surgeon, stating necessity of nsaid administration and operation risk assessment must be...

2 years ago
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RE: Treatment protocol sarcoma with mets

@mkk you may ask your doctor whether foxm1 directed therapy is eligible for this type of sarcoma: FOXM1 in sarcoma: role in cell cycle, pluripotency...

3 years ago
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RE: Treatment protocol sarcoma with mets

valproate, probably less potent, is cheaper alternative to HDACi drugs in above article.

3 years ago
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RE: Treatment protocol sarcoma with mets

Histone deacetylase inhibitors vorinostat and panobinostat induce G1 cell cycle arrest and apoptosis in multidrug resistant sarcoma cell lines In th...

3 years ago
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RE: Treatment protocol sarcoma with mets

Hi Johan Thank you for reminding that. I completely forgot the point that EGCG and other catechins degrade in alkaline environment. The relation b...

3 years ago
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RE: Treatment protocol sarcoma with mets

@mkk for colloidal silver therapy you might be interested in nanoparticles that specifically designed to be absorbed by tumor cells. E.g./p> this ar...

3 years ago
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RE: MRI impact on tumor

Hi Daniel To be precise: patient has a history of allergy to contrast agent. All previous MR scans where contrast agents used resulted in tempora...

3 years ago
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Replies: 3
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RE: Treatment protocol sarcoma with mets

for cic-dux4 mouse tests with dinaciclib show growth suppression: but drug isn't approved yet. may be you could check for ongoing trials if there...

3 years ago
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