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Topics: 42 / Replies: 54
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Replies: 1
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RE: Clioquinol Zinc Ionophore for Terminating Advanced “Decreased Zinc” Testosterone-Dependent Prostate Cancer: A Case Report

Jan 07, 2021: PSA=1.00 PRL=16.0 Casodex Mar 09, 2021: PSA=0.68 PRL=3.00 Casodex + Cabergoline Jun 02, 2021: PSA=0.73 PRL=2.00 ...

1 week ago
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RE: Pyrrolomycins Are Potent Natural Protonophores

Potassium channel openers are uncoupling protonophores Excessive build-up of mitochondrial protonic potential is harmful to cellular homeostasi...

2 weeks ago
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RE: High levels of potassium in parasite cancer cause T cell exhaustion

Anti-Echinococcus (Anti-Cancer) Drug Therapy: Nitazoxanide [Ref] Itraconazole [Ref] Tamoxifen [Ref] Metformin [Ref] Nelfinavir [Ref] Glibencl...

2 weeks ago
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RE: Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I–deficient and MHC I+ tumors

Vadimzan (dimethyl-xanthone acetic acid) is the only STING agonist. Despite positive results at the preclinical stage, vadimezan failed in human c...

2 weeks ago
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RE: 1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells

@j You're welcome! My reply was actually quotes from Prof. Trevor Marshall's articles, which are detailed on his website.

3 weeks ago
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RE: 1α,25(OH)2D3 reverses exhaustion and enhances antitumor immunity of human cytotoxic T cells

1alpha,25(OH)2D3 (calcitriol) is a vitamin D receptor (VDR) agonist, so other VDR activators such as curcumin, gamma-tocotrienol, etc. may also enhanc...

3 weeks ago
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RE: Pyrrolomycins Are Potent Natural Protonophores

Short-chain fatty acids such as Butyrate and medium-chain fatty acids are not protonophore, only long-chain acids such as Stearate are protonophore an...

3 weeks ago
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RE: Pyrrolomycins Are Potent Natural Protonophores

Uncoupling of oxidative phosphorylation by curcumin Curcumin is a phytochemical isolated from the rhizome of turmeric. Recent reports have shown cu...

3 weeks ago
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RE: Pyrrolomycins Are Potent Natural Protonophores

Thanks @daniel, it seems that drugs containing salicylic acid and its derivatives, such as salicylamide and salicylanilide, act as protonophores. Howe...

3 weeks ago
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Replies: 8
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RE: Combination Effects of Polyphenols Present in Sugarcane on Proliferation in MCF-7 Human Breast Cancer Cells

Total antioxidant content of alternatives to refined sugar Abstract Background: Oxidative damage is implicated in the etiology of cancer, cardiova...

3 weeks ago
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RE: Dosage and usage of pure Fenbendazole

Fenbendazole Dosage Guide The opinions expressed here reflect our personal experiences and ongoing investigations into the use of fenbendaz...

3 weeks ago
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RE: Synergy of a STING agonist and an IL-2 superkine in cancer immunotherapy against MHC I–deficient and MHC I+ tumors

Pharmacological activation of the host STING pathway can trigger T cell-mediated tumor regression and make immunologically ‘cold’ tumors ‘hot’.‘Cold’,...

3 weeks ago
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RE: Diosmin in combination with naringenin enhances apoptosis in colon cancer cells

So, eating citrus fruits (naringenin) with their peels (diosmin) increases apoptosis in colon cancer cells!

1 month ago
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RE: Regulation of lactate production through p53/β-enolase axis contributes to statin-associated muscle symptoms

Statins also increase intracellular lactate by inhibiting the monocarboxylate transporter (MCT4), so they acidify both intracellular and extracellular...

1 month ago
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RE: Aspirin in combination with Letrozole or Olaparib induced apoptosis in estrogen receptor-positive T-47D & triple negative MDA-MB-231 breast cancer cell lines

Aspirin overdose also causes glycine depletion and hypoglycinemia. Interestingly, depletion of extracellular glycine may prevent rapid proliferat...

1 month ago
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RE: Aspirin in combination with Letrozole or Olaparib induced apoptosis in estrogen receptor-positive T-47D & triple negative MDA-MB-231 breast cancer cell lines

Our data showed that combined treatments of 50 nm Letrozole or 250 nm Olaparib with 5mm, 2.5mm Aspirin for 48 & 24 h respectively promoted apoptos...

1 month ago
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RE: Pyrroloquinoline Quinone Inhibits Lactate Dehydrogenase

@dng050 OXPHOS deficiency characteristic of all cancer cells, and restoration of OXPHOS is highly therapeutic by Quinone molecules. Cancer cells have,...

1 month ago
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RE: Pyrroloquinoline Quinone Inhibits Lactate Dehydrogenase

INACTIVATION OF LACTATE DEHYDROGENASE BY SEVERAL CHEMICALS: IMPLICATIONS FOR IN VITRO TOXICOLOGY STUDIES Abstract Lactate dehydrogenase (LDH) ...

1 month ago
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