Anti PD-1 and anti PD-L1 Immunotherapies

Summary: A very new and promising immunotherapy approach to the treatment of cancer is the use of immune checkpoint inhibitors. These treatments work by “taking the brakes off” the immune system, so that the immune system becomes more effective in attack against cancer. Several different types of checkpoint inhibitors, targeting different checkpoints or “brakes” on immune
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Antihistamine to reverse immunosuppressive mechanism in cancer

Histamine is produced in the human body by some of the white blood cells called basophils, eosinophils, and by mast cells found especially numerous at sites of potential injury €” the nose, mouth, and feet, internal body surfaces, and blood vessels. Its role is to increase the permeability of the capillaries to white blood cells and some proteins, to
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Autoimmune disease & Quercetin

Autoimmune disease is aabnormal immune response of the body against substances and tissues normally present in the body. In other words the immune system starts attacking healthy parts of the body. I decided to shortly write about thisdisease since it is a potential side effect following treatments with immunotherapies such as DendriticCells or anti PD1/PDL1
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Pancreatic Cancer

The list below will be continuously updated. Alpha-lipoic acid + low-dose naltrexone: Revisiting the ALA/N (alpha-lipoic acid/low-dose naltrexone) protocol for people with metastatic and nonmetastatic pancreatic cancer: a report of 3 new cases. Dipyridamole  Chloroquine see also my post on Chloroquine. Biological Approaches to Therapy of Pancreatic Cancer A triple combination of atorvastatin, celecoxib
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A fit for ketogenic diet

One short but important point: for cancers with no or limited mitochondria use ketogenic diet. That will be very effective. Why? The cancer cells will not be able to switch on fuels other than glucose. ccRCC seems to be a cancer characterized by low to no mitochondria.


CAS 22494-42-4 My opinion: An anti-cancer treatment with great potential relevant for most types of cancers visible on PET/CT. Regarding its effectiveness, this statements says it all: “33 patients were evaluable for metric response, 20 for metabolic and 19 for tumor marker response assessment. For tumor marker follow up 11 % had a CR, 53 %
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Some of the most effective treatments in my opinion

Here is a list of some of the most effective anti-cancer treatments I am currently aware of: Salinomycin – a potassium inophore that will interfere with intracellular potassium. If delivered in the right dose, there is a high chance of affecting the cancer cells while not affecting the normal cells. It has been used on
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Induced Hypothyroidism (Hypothyroxinemia)

My opinion: This is one of the very interesting potential anti-cancer treatments and I am very enthusiast about it. It is relevant for most type of cancers, it is cheap and accessible and can be performed at home, while tracking some of the thyroid hormones via weekly blood tests. Its effectiveness in prolonging life (or even obtaining complete
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Plerixafor (Mozobil)

My opinion: Plerixafor works against the part of immune system (M2–macrophages) that helps the tumor to regrow after an effective treatment has succeeded to kill part of it. Therefore, Plerixafor is a great supportive treatment for any effective anti cancer strategy including surgery, chemo and radiotherapy. We do not have any experience with it. Summary & Mechanism The immune system plays a major
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3BP IV Administration Protocol and Treatment Strategy

Update 03.03.2016: based on clear evidence IV Alpha Lipoic Acid (300-600mg) can inhibit the effectiveness of 3BP –> we may want to avoid that during 3BP treatment and use only when 3BP action is intended to be stopped. For readers, you may want to first read this page and consider being treated at a clinic such as those suggested at
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Adding content

I expect this weekend I will have time enough to start adding more content to the blog. If you have any preference regarding the focus of this content, please write a suggestions. If not I will just pick some areas myself.

Colon and Colorectal Cancer

Here are a few relevant elements. I will further improve the page when possible: Artesunate (Artemisinin): Cheap anti-malaria drug shows promise against colorectal cancer  Monocarboxylate transport inhibition potentiates the cytotoxic effect of 5-fluorouracil in colorectal cancer cells  In other words, Quercetin, Ibuprofen, Statins, Apigenin, etc. will help while Butyrate may not help in this specific case,
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ACC (Adrenocortical Cancer)

Recent (June 2018) case report indicating that checkpoint inhibitors that target PD-1 may be dangerous in some ACC patients: Rapid disease progression in a patient with mismatch repair-deficient and cortisol secreting adrenocortical carcinoma treated with pembrolizumab (Ref.) Update Nov 2019: A report on a phase II study to evaluate the clinical activity of pembrolizumab in ACC
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