When cancer is deprived of essential nutrients Acetate is the fuel

Glucose is one of the principal fuels when it comes to cancer cells. More recently it has become clear that other fuel sources, including glutamine, lipids, and protein also play an important role in cancer. However, I was not aware about the relevance of acetate as a fuel for cancer cells. Indeed, while acetate can
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Electric and Electro-Magnetic Fields & Cancer Treatment

This is a fascinating field in cancer treatment. While various electro-magnetic-wave-based solutions have been proposed during the past century to treat cancer, only recently this treatment strategy started to gain momentum as both academia and the industry started to recognize the value. In this context, field based solutions for cancer treatment have even been approved recently by FDA
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Myeloma

Statin-Dipyridamole Statin-Dipyridamole combination for hematologic malignancies (and not only) New therapies are urgently needed for hematologic malignancies, especially in patients with relapsed acute myelogenous leukemia (AML) and multiple myeloma. We and others have previously shown that FDA-approved statins, which are used to control hypercholesterolemia and target the mevalonate pathway (MVA), can trigger tumor-selective apoptosis. Our
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Treating Ascites with Angiogenesis Inhibitors

Malignant ascites are side effects of some cancers (and potentially anti-cancer treatments), characterized by the accumulation of fluid in the abdomen. Recently, I have received from a friend this article on ascites (from epithelial ovarian cancer), and thought is a good idea to share this here: Macrophage Blockade Using CSF1R Inhibitors Reverses the Vascular Leakage Underlying Malignant Ascites in
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Imiquimod: Potential treatment for Skin Metastasis

Summary  Safe, Effective and Accessible. Used originally on genital warts, it has proven beneficial in the treatment of basal cell carcinoma and can be useful in the treatment of skin metastasis such as those from malignant melanoma, breast cancer and others. Case reports  Imiquimod in the Treatment of Breast Cancer Skin Metastasis: We report a case of breast
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Phlorizin & Phloretin: a powerfull glucose transport inhibitor

Summary  I know and like Phloretin since long time ago but today I came across a very interesting (old) patent that is based on Phlorizin (a derivative of Phloretin) as an anti cancer treatment. Based on the science behind, safety and case reports, I think this is very interesting and below I will share the information
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Gelum Drops: reducing lactic acid, increasing hemoglobin and lymphocytes

This is a German product that has been recommended to me by a German friend (Thank you!) and though I should share that with all the readers. So here it is her e-mail: “Just wanted to give you some information about a product, which you can share also with others (if you like). A natural
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Phosphoethanolamine & Meclizine: inhibiting an enzyme required to form the building blocks of membranes

Summary Actually, the title (inhibiting an enzyme required to form the building blocks of membranes) refers to Meclizine since as we will shortly discuss below, Phosphoethanolamine acts (probably) on mitochondria. The compound, Phosphoethanolamine, has been shown to kill tumor cells (A. K. Ferreira et al. Anticancer Res.32, 95€“104; 2012) at the University of S£o Paulo in Brazil. As a result some
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Anti cancer drugs and supplements

Below is a piece of a recent nice article proposing a broad-spectrum integrative approach for cancer prevention and treatment. I find it interesting specifically because the article is suggesting a large list of drugs and supplements that are easy to access while addressing multiple anti cancer mechanisms. The article is entitled: Designing a broad-spectrum integrative approach for cancer
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Chloroquine & Hydroxychloroquine: supporting chemo effectiveness and more

Summary Chloroquine is an anti-malarial drug available at pharmacies for people traveling to area with malaria risks. Note: based on a RGCC chemosensitivity analysis I have seen at a German clinic, Hydroxychloroquine has been effective in killing the cancer cells of 5 out 7 patients that were tested. It is one of very few available drugs
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Perillyl Alcohol (POH) for brain tumors via nasal spray

Summary A less known but very effective natural anti cancer element, Perillyl alcohol is isolated from the essential oils of several plants including citrus, cherries, lavender, peppermint, spearmint, celery seeds, sage, cranberries, lemongrass, ginger grass, etc. Accessible at Medicor (see below) or it can be ordered from chemical suppliers under the CAS 18457-55-1. Oral administration has lead
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Gut bacteria amplifies immunotherapy: the power of Probiotics

Today, I came across this very interesting news, adding support to a fast growing amount of knowledge suggesting a strong connection between gut bacteria and the immune system: Gut bacteria can dramatically amplify cancer immunotherapy “Introducing certain bacteria into the digestive tracts of mice with melanoma can help their immune systems attack tumor cells. The gains were
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Potential solutions against Cachexia: Glutaminolysis inhibitors and more

Conclusion To avoid cachexia we need to reduce the request for glutamine via lactate (see the seven points below) and in order to kill cancer cells relying on glutamine we should reduce/inhibit glutaminolysis (e.g. EGCG), reduce glutamine transport (retinoic acid), reduce blood glutamine (phenylbutyrate and avoid (red) meet). Background Cachexia is loss of weight, muscle
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