Background: Many cancers either metastasize to the skeleton or grow primarily within the bone marrow, where this growth frequently leads to hypercalcemia, severe bone pain, skeletal destruction, and pathologic fractures. Indeed, the skeleton is the most common site of metastatic disease, and some of the patients with advanced cancer may develop skeletal lesions (Ref.). Bisphosphonates (BPs)
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Your Contribution Needed on Ovarian Cancer Story from Ergin
Dear Friends, During the past year, this website has grew seriously in terms of number of visitors. Given the type of information discussed here, this website attracts visitors that are well informed regarding treatment options, including medical doctors, scientists, private-clinics owners but also many people like myself, all driven by one of the strongest motivations that a human
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My Dear Sweet Wife is An Angel Now …
Dear Readers & Friends, With a deep regret and pain in my heart I have to write this post … my sweet dear wife Mihaela Catalina Stanciu has become an angel … My treasure passed into eternity on Tuesday, October 18th at 22:25, the Netherlands and her funeral took place on Sunday, October 23rd in Romania (Drobeta
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Thalidomide: From Medical Disaster to Miraculous Cancer Treatment
Background: In 1957, Thalidomide was an over the counter drug used by pregnant women in West Germany, against morning sickness and nausea. Thalidomide, was hailed as a wonder drug that provided a safe, sound sleep. Unfortunately the complete spectrum of Thalidomide’s action were not well understood at that time, and shortly after the drug was brought to the
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Increasing Radiation Effectivness
I intend to have this post evolving over time as I have a large collection of research indicating various approaches to enhance the effectiveness of radiotherapy. Therefore, I am not going to debate on whether radiotherapy is good or bad. Instead, I will focus on how to make the best of it once we decided to
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Androgen Receptor and Cancer
Background: One of the subjects I investigated during the past weeks is the role of androgen in cancer. Androgen receptors (AR) blockage is a treatment strategy used in e.g. prostate cancer, in order to stop or reduce cancer progression. However, as you will see from the papers cited below, and these are just a few out
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Dimethyl Fumarate: An Anti Psoriasis Drug Works Against Tumors
Background: A recent press release from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) discuss the results of German researchers who demonstrated that dimethyl fumarate (DMF), a drug used to treat Psoriasis patients can also help in the fight against cancer. This study has been performed on lymphomas and DMF appears to have at least comparable effectiveness and is better
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Serotonin Makes Tumors Happy Too
Serotonin and its Role: Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system of humans. Serotonin is manufactured in the brain (dorsal raphe nucleus cells, which are located deep in the brain) and the intestines and is primarily stored in and transported by
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CRM197: An Anti Cancer Vaccine Discovered in Italy
Background: I came across this treatment route a few years ago and I had and still have a very good feeling about it. So, I thought it may help to increase the awareness if I share here a bit about it: CRM197 (cross-reacting material 197) is a non-toxic form of diphtheria toxin. Diphtheria is an infection caused by
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Itraconazole: An Antifungal Drug With Anti Cancer Properties
Background: Itraconazole is a FDA approved drug, developed as an orally administrated antifungal drug, and has been used clinically for many decades with a well-established safety record. It has been used in the prevention and treatment of a broad range of fungal infections, such as aspergillosis, blastomycosis, candidiasis, histoplasmosis, but also in various dermatological and nail infections. Since
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The Immune System Fights Cancer as a Metabolic Disease
Background: Scientists at the University Hospital and the DKFZ in Heidelberg, Germany have discovered that a protein from immune cells paralyzes the energy supply in tumor cells. The German Society of Pathology has awarded them with the Novartis Prize. The scientists have recently published their findings in Nature Communications. (Ref.) Mechanism: Natural killer cells “patrol”
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Maraviroc: An anti-HIV Drug that Reactivates the Immune System to Fight Cancer
Introduction: Recently, with the help of a reader of this website (Thank you, Jose!), I came across a very relevant article, Immunotherapy in metastatic colorectal cancer for the first time utilizes the innate immune system, published on the website of the German Cancer Consortium (DKTK). This article describes the results of a recent clinical trial running in Heidelberg, Germany using an
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Omega-3 Fatty Acids, Budwig Diet & their Antitumor Activity
Summary: This is a long post so here is a short summary: Omega-3 fatty acids have anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. Because Omega-3 fatty acids are pushing out of the cancer cells the glutathione much needed for the cancer cell survival, Omega-3 fatty acids can be also combined with chemo and with that increase or enable chemo
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Citric Acid Inhibits Fermentation
Background: Citric acid exists in large amounts in a variety of fruits and vegetables, most notably citrus fruits and was first time isolated from lemon juice. Its salt form, Citrate, is an intermediate in the citric acid cycle (also called TCA cycle, TriCarboxylic Acid cycle, Krebs cycle, Szent-Györgyi – Krebs cycle), a central metabolic pathway for animals, plants and
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High Dose Vitamin C & Cancer
Background: L-ascorbic acid (C6H8O6), known as Vitamin C, has a variety of functions in humans, some of which are not yet fully understood. It was discovered in 1930 by Albert Szent-Györgyi (Hungarian, half Romanian by descent), who as a result of this discovery received Nobel Prize in Physiology or Medicine in 1937. Note, that Albert Szent-Györgyi is the same scientist
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Creatine: Counteracts Cachexia and Supports Methylglyoxal
Background: Creatine is a nitrogenous organic acid that occurs naturally in vertebrates and helps to supply energy to all cells in the body, primarily muscle. It is produced in the human body from the amino acids glycine and arginine. Creatine supplements are widely used by athletes, bodybuilders, wrestlers, sprinters, and others who wish to gain muscle mass,
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Plerixafor: Exposing Hidden Enemies & Cimetidine: Not Letting Them Hide
In an article published on May 25, 2016 in Science Translational Medicine, the researchers discuss how breast cancer cells are hunting for specific blood vessels that contain a molecule called E-selectin. (Ref.) This molecule exists in specific blood vessels in bone marrow and this is how cancer cells get there. Once they get there, they enter the tissue inside bones
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Today’s Project: Whole Plant Extracts
Today I spent a few hours preparing ethanol/water and DMSO/water extracts of Curcuma, Ginseng and Artemisia Annua. The outcome (including the formulation) is shown in the picture below. The idea for using not only ethanol or DMSO but also water is to extract the water soluble components too. The intention is to use these extracts
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Hyaluronic Acid Modulation: Preventing Recurrence or Supporting Other Therapies – Otherwise Better Not
Recently, I was reading this article Why cancer drugs can’t take the pressure, arguing that “A major reason why cancer drugs fail is that they cannot penetrate the high-pressure environment of solid tumors.” and that the reason for that is a “naturally occurring molecule called hyaluronic acid, primarily responsible for generating elevated gel-fluid pressures in tumors.”
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Methylglyoxal: Large Response Rate in Very Advanced Stages
Introduction: Methylglyoxal, a molecule also produce by human body, it is one of the substances with an anti cancer potential that stands out. I am enthusiast about it because of the following facts: It has clear science behind supported by a large amount of academic research Its anti cancer potential has been already demonstrated in humans It
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