Anti Cholesterol Strategy to Fight Cancer

Background So far I wrote several posts that are in a way or another related to cholesterol & cancer, underlying the role of Cholesterol in cancer. More specifically, we have seen that drugs or supplements that reduce or inhibit the absorption, use and/or production of cholesterol in cancer cells, have also the potential to kill cancer cells: Ref. Indeed,
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Your Contribution Needed on Non Small Cell Lung Cancer Story from PaulF

Dear Friends, I was recently contacted by PaulF, who kindly asked our help on generating ideas on options that he may consider for his dear sister who was just diagnosed with stage 4 non small cell lung cancer two weeks ago. On the same line as the post from Ergin, https://www.cancertreatmentsresearch.com/your-contribution-needed-on-ovarian-cancer-story-from-ergin/ I would like to invite you
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Amanita Phalloides: Tumors Don’t Like Mushrooms

Background: Amanita phalloides (Agaricus phalloides), also known as the death cap, is a deadly poisonous mushroom. It is widely found in Europe and because it looks similar to other mushrooms that are edible, every year there are reports of people dying as they mistake death caps for edible mushrooms (Ref.) This is because toxins from Amanita cause necrosis
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Taurolidine: A Disinfectant & Inhibitor of Tumor Growth

Background: Taurolidine is a molecule that comprises Taurine (the most abundant free amino acid in the heart, retina, skeletal muscle, brain, and leukocytes). It was first produced in the 1970s by Geistlich-Pharma Inc, designed as a broad-spectrum antibiotic and used in the local treatment of peritonitis. (Ref.) It is effective against both aerobic and anaerobic bacteria. (Ref.) Due to
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Bisphosphonates: Against Skeletal Lesions + Direct Anti-Tumor Action

Background: Many cancers either metastasize to the skeleton or grow primarily within the bone marrow, where this growth frequently leads to hypercalcemia, severe bone pain, skeletal destruction, and pathologic fractures. Indeed, the skeleton is the most common site of metastatic disease, and some of the patients with advanced cancer may develop skeletal lesions (Ref.). Bisphosphonates (BPs)
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Thalidomide: From Medical Disaster to Miraculous Cancer Treatment

Background: In 1957, Thalidomide was an over the counter drug used by pregnant women in West Germany, against morning sickness and nausea. Thalidomide, was hailed as a wonder drug that provided a safe, sound sleep. Unfortunately the complete spectrum of Thalidomide’s action were not well understood at that time, and shortly after the drug was brought to the
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Dimethyl Fumarate: An Anti Psoriasis Drug Works Against Tumors

Background: A recent press release from the German Cancer Research Center (Deutsches Krebsforschungszentrum, DKFZ) discuss the results of German researchers who demonstrated that dimethyl fumarate (DMF), a drug used to treat Psoriasis patients can also help in the fight against cancer. This study has been performed on lymphomas and DMF appears to have at least comparable effectiveness and is better
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Serotonin Makes Tumors Happy Too

Serotonin and its Role: Serotonin or 5-hydroxytryptamine (5-HT) is a neurotransmitter primarily found in the gastrointestinal tract (GI tract), blood platelets, and the central nervous system of humans. Serotonin is manufactured in the brain (dorsal raphe nucleus cells, which are located deep in the brain) and the intestines and is primarily stored in and transported by
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Itraconazole: An Antifungal Drug With Anti Cancer Properties

Background: Itraconazole is a FDA approved drug, developed as an orally administrated antifungal drug, and has been used clinically for many decades with a well-established safety record. It has been used in the prevention and treatment of a broad range of fungal infections, such as aspergillosis, blastomycosis, candidiasis, histoplasmosis, but also in various dermatological and nail infections. Since
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The Immune System Fights Cancer as a Metabolic Disease

Background: Scientists at the University Hospital and the DKFZ in Heidelberg, Germany have discovered that a protein from immune cells paralyzes the energy supply in tumor cells. The German Society of Pathology has awarded them with the Novartis Prize. The scientists have recently published their findings in Nature Communications. (Ref.) Mechanism: Natural killer cells “patrol”
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Maraviroc: An anti-HIV Drug that Reactivates the Immune System to Fight Cancer

Introduction: Recently, with the help of a reader of this website (Thank you, Jose!), I came across a very relevant article, Immunotherapy in metastatic colorectal cancer for the first time utilizes the innate immune system, published on the website of the German Cancer Consortium (DKTK). This article describes the results of a recent clinical trial running in Heidelberg, Germany using an
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Omega-3 Fatty Acids, Budwig Diet & their Antitumor Activity

Summary: This is a long post so here is a short summary: Omega-3 fatty acids have anti-inflammatory, antiproliferative, proapoptotic, antiangiogenetic, anti-invasion, and antimetastatic properties. Because Omega-3 fatty acids are pushing out of the cancer cells the glutathione much needed for the cancer cell survival, Omega-3 fatty acids can be also combined with chemo and with that increase or enable chemo
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Citric Acid Inhibits Fermentation

Background:  Citric acid exists in large amounts in a variety of fruits and vegetables, most notably citrus fruits and was first time isolated from lemon juice.  Its salt form, Citrate, is an intermediate in the citric acid cycle (also called TCA cycle, TriCarboxylic Acid cycle, Krebs cycle, Szent-Györgyi – Krebs cycle), a central metabolic pathway for animals, plants and
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High Dose Vitamin C & Cancer

Background: L-ascorbic acid (C6H8O6), known as Vitamin C, has a variety of functions in humans, some of which are not yet fully understood. It was discovered in 1930 by Albert Szent-Györgyi (Hungarian, half Romanian by descent), who as a result of this discovery received  Nobel Prize in Physiology or Medicine in 1937. Note, that Albert Szent-Györgyi is the same scientist
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Creatine: Counteracts Cachexia and Supports Methylglyoxal

Background: Creatine  is a nitrogenous organic acid that occurs naturally in vertebrates and helps to supply energy to all cells in the body, primarily muscle. It is produced in the human body from the amino acids glycine and arginine. Creatine supplements are widely used by athletes, bodybuilders, wrestlers, sprinters, and others who wish to gain muscle mass,
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