Leukemia

I was shortly looking through potential solutions forLeukemia and here is a summary of my (limited) view on that so far:

A major approach when trying to treat leukemia is to focus on Iron depletion (chelation).
This can be done with Artemisin, Baicalein and Ciclopirox olamine or even Galium compounds.
.
Next to that, as you can see in the references below, Salinomycin, 3BP, Niclosamide and Ivermectin may be suitable.
.
Thus, salinomycin should be regarded as a novel and effective agent for the elimination of leukemia stem cells and other tumor cells exhibiting ABC transporter-mediated multidrug resistance.http://www.ncbi.nlm.nih.gov/pubmed/20350531
.
Chelation of intracellular iron with the antifungal agent ciclopirox olamine induces cell death in leukemia and myeloma cells. http://www.ncbi.nlm.nih.gov/pubmed/19589922
.
Baicalein:Based on its traditional use and the documentation of its antitumor effects against various human cancer cell lines, baicalein has been used recently by doctors in Asia as a complementary supplemental agent in the treatment of hepatomas and leukemia in human subjects.
(Baicalein is also an Iron chelator)
.
Niclosamide has shown antiproliferative activity in a broad spectrum of cancer cells including hematologic cancer cells (e.g., acute myeloid leukemia, AML) and solid tumor cells (e.g., colon cancer, breast cancer, and prostate cancer) http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777479/#!po=6.25000
.
The antiparasitic agent ivermectin induces chloride-dependent membrane hyperpolarization and cell death in leukemia cells http://www.ncbi.nlm.nih.gov/pubmed/20644115
.
Regulation of death induction and chemosensitizing action of 3-bromopyruvate in myeloid leukemia cells: energy depletion, oxidative stress, and protein kinase activity modulation.http://europepmc.org/abstract/MED/24307199
.
Mebendazole as a a safe and novel therapeutic approach for acute myeloid leukemia AML. https://www.nature.com/leu/journal/vaop/naam/abs/leu2017317a.html

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

Related Articles


Leave a Reply