Some of the Intracellular Pathways relevant in Cancer

Every problem has a simple answer and everything in life should be simple. If it is complex, we do not understand it yet. However, as long as we do not get stuck into the details, many times we need to go through the complexity of things in order to be able to find answers. We need to constantly zoom in and zoom out and preferably change perspective while doing that, so that we can analyze the challenge from various perspectives.

Below, we have  a good example of detailed view from a certain perspectives on how the cells function and the chemicals that are used as “communication tools” or “communication processing tools” so that specific mechanism will be triggered and take place inside the cell, like for example cell division or demand for supplies.

Therefore, these images reflect part of our understanding today on intracellular communication. “Tomorrow”, breakthroughs will take place and we may realize that some of these views are wrong. So lets not take them as absolute truth but as guides to help us get the context of the academic research in the field.

The ultimate question is not IF but WHICH one of the chemicals (visible or not below) is the answer to cancer in general. I know many of the very good scientists believe there is no one answer to cancer. This is just a matter of feeling and believe and not of knowledge, since no one knows. Well, I believe there is ONE answer. We just have to find it and one day that will happen. Or maybe that already happened but we need to see it.

PI3K/Akt/mTOR Pathway


PI3K-Akt-mTOR Pathway

Protein Tyrosine Kinase


Protein Tyrosine Kinase

Angiogenesis


Angiogenesis

Apoptosis


Apoptosis

JAK/STAT Pathway


JAK-STAT Pathway

MAPK Pathway


MAPK Pathway

Cytoskeletal Signaling


Cytoskeletal Signaling

Cell Cycle


Cell Cycle

TGF-beta/Smad Pathway


TGF-beta-Smad Pathway

DNA Damage


DNA Damage

Stem Cells and Wnt Pathway


Stem Cells and Wnt Pathway

Ubiquitin Pathway


Ubiquitin Pathway

Neuronal Signaling


Neuronal Signaling

NF-κB


NF-κB

GPCR & G Protein


GPCR & G Protein

Endocrinology & Hormones


Endocrinology & Hormones

Transmembrane Transporters


Transmembrane Transporters

Metabolism


Metabolism

Microbiology


Microbiology

Reference for all of the above pictures: Ref

Related Articles


Leave a Reply

8 Comments on "Some of the Intracellular Pathways relevant in Cancer"

avatar
  Subscribe  
Notify of
Mariusz Domanski
Guest

I am really impressed with your knowledge and involvement in this web it’s a black magic to me after finishing medicine over 20 years ago, but I feel I need to share your web address with my friend 🙂

Masato Hada
Guest

To Mr Danil
 The control of ascites, you pointed the efficacy of angiogenesis inhibition, is complete answer. In addition to that、 I think you should explain bevacizumab, sold under the trade name Avastin, is an angiogenesis inhibitor, a drug that slows the growth of new blood vessels. It is impossible to control ascites with Avastin because it acts outside of cells. The drug Avastin trys to control angiogenesis indirectly different from thalidomide and celecoxib that act inside of the cell directly.
It is very important to select small molecular drugs targeting intracellular pathways relevant in cancer cell proliferation.
If you have any questions, don’t hesitate to ask me through inquiry form in thalidomide post.
HadaClinic in Japan
Masato Hada

scottchaverri@hotmail.com
Member

This is amazing. Thank you so much for pulling this together!

scottchaverri@hotmail.com
Member

How do we recreate each of these but instead of showing pharmaceuticals, we show natural compounds?

Wondering
Guest

I dont know if we ever find ONE answer. But if we do it will be related to metabolism as the cancer genom project shows the limitations of focusing on the genes. After all, the oncogenes affect/target primarily metabolism. But the problem is that are several pathways for metabolism too. So its unlikely to block all those with one answer only. Maybe a super intelligent form of 3-bp mixed with metformin and something else, something that can be taken for decades without serious side effect. Something that affect both nucleus and mito for long.