Induced Hypothyroidism (Hypothyroxinemia)

My opinion:

Note (2018): Next to the scientific reports described below, there are several people who used this treatment strategy so far without any specific success. One of the visitors strongly believes that this treatment approach is even dangerous, specifically when a patient decides to stop this treatment approach. I added this warning here as the visitor strongly insisted this would help people and as soon as I have scientific research that agrees or disagrees with this warning, I will add references and update this article. (off course any reader is welcome to send me research and opinion he/she may have on this line)

This is one of the very interesting potential anti-cancer treatments and I am very enthusiast about it. It is relevant for most type of cancers, it is cheap and accessible and can be performed at home, while tracking some of the thyroid hormones via weekly blood tests. Its effectiveness in prolonging life (or even obtaining complete remission)  has already demonstrated on humans and published recently, while the theory is 20-30 years old.

As a result, I would strongly suggest to discuss this option with your doctor.

Summary & Mechanism

Hypothalamus sends signals to pituitary gland via the hormone TRH. Pituitary gland than sends the signal to the Thyroid gland via the hormone TSH.  As a result Thyroid gland will start producing T4 hormone as well as T3. However, most (95%) of the hormone produced in thyroid is T4 (Thyroxine) while T3 (Triiodothyronine) is produced based on T4 in other organs, but most in the liver.  T3 is the active form of thyroid hormone which is produced as a result of one iodine being cleaved from T4.

In a study from 2015, 23 stage IV cancer patients, were treated by inducing hypothyroxinemia, which means lowering thyroid hormone T4 levels. This T4-depleting therapy far exceeded the expected survival in most cases. They achieved this simply by lowering the activity of the thyroid with the help of a common drug and at the same time supplementing the T3, via oral administration of T3 capsules. In case of the patients with low thyroid function, previously on T4 supplementation, they just had to stop T4 supplementation and replace that with T3 capsules. As a result, T3 has been maintained in normal range while T4 was pushed down below the normal range.

Note: About 60% of the T4 is converted into T3, 20% is converted into an inactive form of thyroid hormone known as reverse T3 (irreversible), and the remaining 20% is converted into T3S (T3 sulfate) and T3AC (triiodothyroacetic acid). Reverse T3 can be problematic; even though it is inactive, it will still bind to T3 receptors and block T3 from binding and working its magic on metabolism.  Too much or too little cortisol that is produced by the adrenal glands will increase circulating levels of reverse T3.  This mechanism is due to suppressed liver detoxification and clearance of reverse T3 from excess cortisol production.  Stress can not only cause signs of hypothyroidism but it will also impair the liver€™s ability to detoxify.  Cortisol will also suppress TSH production resulting in low thyroid function. (Ref.)

Case reports

2015: Medically induced euthyroid hypothyroxinemia may extend survival in compassionate need cancer patients: an observational study.

Spontaneous remission of cancer–a thyroid hormone dependent phenomenon? http://www.unboundmedicine.com/medline/citation/10697597/Spontaneous_remission_of_cancer__a_thyroid_hormone_dependent_phenomenon

GBM ON L-T4 GBM O L-T4 -3 WEEKS GBM ON L-T4 GBM O L-T4 -On T3 ON L-T4 O L-T4 -3 On T3 HYPOTHYROXINEMIA MEDIATED BY EXOGENOUS 3,5,3′-TRIIODO-L-THYRONINE [T3] IS ASSOCIATED WITH TUMOR RESPONSE IN CANCER PATIENTS: A COMPASSIONATE CARE EXPERIENCE

67 year old woman on L-T4 supplementation pre and post CRANIOTOMY and biopsy -of 3.5×3.5 cm L. parieto-occipital glioblastoma[GBM]. Rapid Performance Status deterioration while on post-operative radiation therapy [3960cGy] and Temodar –From ECOG 1 TO 3[KPS80 to 40] –patient incapacitated No response to high dose dexamethasone. Memory impairment and visual eld loss. MRI showed signicant tumor enlargement, 6X5cm contralateral spread and vasogenic edema. Recovery not expected. Patient’s 75 ug /day L-T4 discontinued –exogenous T3 initiated . After 7 days signicant clinical and neurological improvement-patient become ambulatory. At 3 weeks MRI shows signicantly smaller tumor and decrease in vasogenic edema. CLINICAL COURSE radiation therapy and chemotherapy. L-thyroxine supplementation 88 mcg/day. Exogenous T3 initiated 6.25mcg x 3 /day.

Safety/Toxicity

See the above case report.

Preparation & Administration

Methimazole 40€“50 mg/day (single dose or divided doses) and L-T3 5€“6.25 mg 3 times per day were used initially while adjusting doses at 2- to 4-week intervals until serum TSH concentration was reduced to the lower limit of the reference range and FT4 had fallen below reference range and stabilized.The final doses of methimazole ranged from 20 to 50 mg/day in single or divided doses and L-T3 ranged from 5 to 12.5 ug 2 or 3 times per day up to a maximum of 37.5 ug/day. (Ref.)

T3 should be taken on an empty stomach, 2h after food 1h before eating again.

Source & Cost

Methimazole can be bought at online pharmacies on the web

Source T3

Both are cheap enough to be accessible to anyone.

Synergists & Antagonists

Not available

Other relevant links:

1981: Inhibition of Local and Metastatic Hepatoma Growth and Prolongation of Survival after Induction of Hypothyroidism http://cancerres.aacrjournals.org/content/41/8/3040

2013: Thyroid hormone, thyroid hormone receptors, and cancer: a clinical perspective http://erc.endocrinology-journals.org/content/20/2/R19?cited-by=yes&legid=erc;20/2/R19

2015: Medically induced euthyroid hypothyroxinemia may extend survival in compassionate need cancer patients: an observational study.  http://www.ncbi.nlm.nih.gov/pubmed/25410096

Cancer Cell Gene Expression Modulated from Plasma Membrane Integrin αvβ3 by Thyroid Hormone and Nanoparticulate Tetrac. http://www.ncbi.nlm.nih.gov/pubmed/25628605

Integrin αvβ3-Targeted Cancer Therapy http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2901818/

Spontaneous remission of cancer–a thyroid hormone dependent phenomenon? http://www.unboundmedicine.com/medline/citation/10697597/Spontaneous_remission_of_cancer__a_thyroid_hormone_dependent_phenomenon

Mitotane Treatment in Patients with Adrenocortical Cancer Causes Central Hypothyroidism. http://www.ncbi.nlm.nih.gov/pubmed/26221968

Thyroid hormones and cancer: clinical studies of hypothyroidism in oncology http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.658.2074&rep=rep1&type=pdf Accumulating clinical evidence may justify new, broadly-based controlled studies in cancer patients of the possible contribution of thyroid hormone to tumor behavior

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

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Ergin
Member
Ergin

Dear Daniel,
One more time ,you are exactly right.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4558111/
Finally, the hormone may limit chemotherapy-induced apoptosis by shortening intracellular residence time of anticancer drugs that are pro-apoptotic. All of these factors are possible clinical contributors to chemotherapy resistance.

How i miss hormone section from lots of months?!!!
T4 is anti-apoptotic.
We all have to talk more on hormones.

Kind Regards
Ergin

Paul
Guest
Paul

We will try it as my wife already has hypothyroidism we need only drop T4 and take T3 pills.

Kind regards
Paul

Ergin
Member
Ergin

Dear Paul,
When i see you message,i shout and say yes:).I am happy about you.
Now we are together.I am nearly 18 days before you.
T4 is declining slowly,it takes more than 30 days to reach nadir.But you will see TSH will rocket for some days.
And we saw no side effect.
Kind Regards
Ergin

Paul
Guest
Paul

Dear ergin,

We started lowering T4 around new year, we came down from 24 to 15 so far, it takes its time. Site on top of page for T3 purchase is not functional. As TSH is 10 we need T3 supplement badly.

Kind regards
Paul

Ergin
Member
Ergin

We began T3 after blood washout period of 1 week.

Alex
Member

“Site is currently under maintenance, checkout is not available”
no phone number found…. needs more digging.

Cheers

Ergin
Member
Ergin

Good results is begining to come from T4 strategy from our Dr.He said we are more powerful with this strategy with iv curcumin +iv vitc.Some of the patients respond quickly.But the only problem is time needed to see long results.And i dont know who didnt respond honestly.
I wrote every step to Emad.I can not say try it.I am not proffesional like doctors,after a bad happening they dont care.But i cant live with this with all my life.I hope you understand.
Some of my mothers tumors gone and lowered in volume on periton on scans this week.
We will see on coming weeks if gemzar alone will work with T4 strategy or not.
Because of late begining to T3,hypothyroidism occured.And markers rose to 400 because of ascid.
I think they are gone now.
I also wonder Paul is doing this strategy or not.

Ergin
Member
Ergin

Dear Friends,
Good results is begining to come from T4 strategy from our Dr.He said we are more powerful with this strategy with iv curcumin +iv vitc.Some of the patients respond quickly.But the only problem is time needed to see long results.And i dont know who didnt respond honestly.
I wrote every step to Emad.I can not say try it.I am not proffesional like doctors,after a bad happening they dont care.But i cant live with this with all my life.I hope you understand.
Some of my mothers tumors gone and lowered in volume on periton on scans this week.
We will see on coming weeks if gemzar alone will work with T4 strategy or not.
Because of late begining to T3,hypothyroidism occured.And markers rose to 400 because of ascid.
I think they are gone now.
I also wonder Paul is doing this strategy or not.

Meech
Member

Hi Ergin,

Really glad you’ve found something which works for you. I’m wondering: are you using just the T4 depletion strategy or have you combined it with chemo or other treatments?

Ergin
Member
Ergin

Dear Meech,
Thank you very much.She is on chemo(Gemzar 1400 mg) with this stratgey(T3 :2 X12,5 mcg/day) +metformin(2x1000mg/day)+iv curcumin(600mg) before chemo+hyperthermia(1hour)+lansoprazole(30mg)+exforge(hypertension).
But before,she tried mebendazole+chloroquine+itraconazole+(hca+citric acid:sure not worked and i hate both)+dca+
collodial silver+iv vitc+melatonin+quercetin+artemisinin+beta glucan+1 shot dapagliflozin before chemo.
So Dear Meech it is very hard to say that which one worked.But in next 4 weeks, i can say that T4 worked or not.
Because she is taking only Gemzar as chemo.
In theory if T4 is a working strategy,it should work alone also.It is a good angiogenesis inhibition strategy.
I highly recommend you to search for dapagliflozin.We need Daniel to enter this subject.
If we are talking on glyco inhibitors and believe that they works,dapagliflozin looks best for my opinion.
On mice tests after 1 hour iv dapagliflozin,there is no glucose inside the tumor.(oral type is sold in pharmacies)
If glycolitic inibhitors are told us as a cure of cancer,isnt dapagliflozin the cure of cancer?
For me it is not,but it should work perfect and helps to the other treatments.
Kind Regards
Ergin

Meech
Member

Thanks Ergin for all of the info.

I’m gonna look into the side effects of dapagliflozin and see if it’s something to add to what I do.

Tanya
Guest
Tanya

Ergin,
Cancer is such a cruel thing. Let’s hope for some good news. We all need it.

Ergin
Member
Ergin

Dear Tanya,
I can take the responsibilty of all drugs that Daniel find,experienced and put here for people to
read,to talk about it and maybe use it.You can try all drugs and look for the results for 1-2 weeks.Nearly all drugs.
But this is a total different strategyThis is not only a drug.
All the load is on my shoulder now.It is too heavy for me to lift.So i have to talk honestly what i saw and experienced.
May be cancer history is changing in this page.At least for some.

I have no luxury to write Dr’s results because he is secreting lots of knowledge from me,it is his job and we are the patient.
He will write an academic paper about it later i think.A serious clinical trial he began about T4 depletion strategy.
I hope i will write lots of valuable results about it on coming weeks,months,years.
Kind Regards
Ergin

Jcancom
Member

Dear D, yes I have been having doubts about being an anti-cancer fighter too. I am sure that there must be others out there that could help out all those in need. Yet, for whatever reason these people usually do not step forward. So, we are left with chemotherapies and other treatments that have been used sometimes for half a century or more.

Yet, at the same there is this overwhelming torrent of cancer research published every day. For many cancer patients all of the research that has been done for all these decades and decades never in any way benefits them. The river of research is so enormous that it is allowed to flow away from the people it could benefit. You have provided a way for people to capture some of this knowledge so that it can be digestible to those many who are coping with this illness. The nearly 1 million visits to your site
clearly show how much others value your contribution!

One also need look no further than the 3-BP saga to see the importance of citizen participation. Years and years after the initial research had been published there still had been not a single published patient. Then a teenager went to Germany and changed the conversation. Sometimes when we are feeling down about things we need to remember that change is possible — even with all the forces that seem to oppose it. The initiative of a single person can change everything! We now might only be a year before the start of a phase 1 trial! I am so happy! Somehow a grass roots effort has forced a clinical trial to occur.

Best Wishes and keep up the great work!

{Heard of thapsigargin? The Arabs call it “death carrot”.
http://www.inspyrtx.com/product-pipeline mipsagargin (G-202)
http://www.hopkinsmedicine.org/news/media/releases/drug_from_mediterranean_weed_kills_tumor_cells_in_mice }

Ergin
Member
Ergin
Tanya
Guest
Tanya

Hi Ergin,

You mentioned in one of your posts that you got in touch with Dr. Hercberg regarding T4 depletion strategy. I am thinking to try it too.
I would do it if I am under supervision of an endocrinologist or somebody experienced with this strategy. It is too scary to mess with your hormones on your own. I really would like to get in touch with Dr. Hercberg and see if he can be of any assistance.
Was it difficult to for you to get in touch with him? Is he willing to talk to cancer patients who are interested in this strategy?
Thank you.

Tanya

Ergin
Member
Ergin

Hi Tanya,
He is a very kind doctor.I am sure he will help you.
What i did:A very short mail because he is very busy with mails.
Just write your illness,stage,chemo or not.And your hormone counts ofcourse.
You can write i dont want to take your too much time and very interested for your treatment etc etc.:)

Kind Regards
Ergin

Tanya
Guest
Tanya

Thank you, Ergin.
Is he involved in your mother’s treatment or turkish doctor manages it by himself?
I am trying to understand how much he is willing to be involved in care of patients trying his strategy.

Thank’s.

Ergin
Member
Ergin

Dear Tanya,Dr Aleck Hercbergs is ofcourse very interested in this strategy.He has lots of patients through internet i think.
May be he will be very very popular on coming years in the world.I hope it works for everyone but time will show us.
If nothing works,how many chances do we have?
You have to read his protocol carefully.It is not very hard to manage dosages.You dont need a doctor if you follow his protocol carefully.Frequent blood counts is must.
Kind Regards
Ergin

Ergin
Member
Ergin

I have learned lots of things about T4 depletion strategy.
We unfortunately left this strategy because of side effects,because of age of my mother.
But i have good feelings about hypothyroidism and chemosensitivity.But hypothyroidism also have some side-effects like edema.
Both T4 and T3 is antagonist to chemo and T4 is much higher.
Dr Aleck Hercbergs said also that the important thing in this strategy is not TSH levels.
With minimum T3 hormones which you can live and see no side effects is the dosage i think.
That is my experience,not knowledge.

Alex
Member

I’m so sorry brother.
i’m not sure but what if the edema is something the body creates to kill and encapsulate the “enemy” in our case, the cancer tumor.
Take care bro.
Alex

Ergin
Member
Ergin

Dear Alex,
How is your mom and you?
Do you remember my mothers all ca markers was rising after hypothyroidism.
Like she is breast cancer,lung cancer etc.
That was clearly because of edema
Best wishes
Ergin

Alex
Member

Thank you brother

I hope things go better for your mother and you.
For now my mother is taking Tarceva and it seems to be helping with her pain.
I remember before her paralisys her CA-19-9 was very high but CEA was lower.

My best wishes to you and everyone here,
Have a great weekend.
Alex

Meech
Member

When I started, four weeks ago my numbers were:

TSH: 6.07 mIU/L
T4 Free: 18 pmol/L
Free T3: 3.4 pmol/L

After two weeks and three days they were:

TSH: 0.14mIU/L
T4 Free: 13pmol/L
Free T3: 5.4pmol/L

It’s been almost two weeks since that last test, and I should be going in for another blood test next week. I don’t feel any shrinkage in palpable tumours. My liver has started to hurt heavily in spots. So for 2 days it’ll hurt in one spot, and refer to the shoulder, then it’ll completely go away, and pain will start a day or two later in another spot in the liver, and that one subsequently completely disappears, etc. Seems like some sort of inflammation or something.

Meech
Member

Still very anemic. Hemoglobin is at 88 (normal is 140+), so it’s been tough standing. I started taking an iron supplement yesterday.

Ergin
Member
Ergin

Dear Meech,
There is stg wrong with your blood counts.
You have used T3 too much.
It is not what we want.
Tsh is too low.Please call me or write an email

Meech
Member

Hi Ergin,

I sent the email.