How to potentially enhance Chemotheraphy effectivness

It is well know that tumors often develop resistance to (chemo) therapies via various mechanisms. Some of the mechanisms are well understood today and there are various drugs or supplements that may have the ability to suppress some of these resistance mechanisms. Bellow, I tried to cover most of the known resistance mechanism and indicate drugs or supplements to address them. In order to maximize the treatment outcome, I would use one element from each of the following categories. In general, I would probably use them about one week before the chemo, during the chemo and some days/weeks after chemo.

Based on the categories mentioned below, here is a nice cocktail:

  • Palmitoylethanolamide – 3 x 400 mg/day – (supplement)
  • Pyrvinium pamoate – 5 mg/kg/day – (over the counter in countries like Sweden, Norway, etc.)
  • Scorpion Venom – (supplement)
  • Omeprazole – 40 to 80mg/day – (over the counter in countries like the Netherlands, Belgium, etc.)
    • to use only if the chemo used is weak basis – if it is weak acid I would not use Omeprazole and stop all proton pump inhibitors during chemo as the weak acid chemo effectiveness may be lowered by proton pump inhibitors.
  • Verapamil – 3 x 80mg/day – (on prescription or online pharmacies)
  • Dipyridamole – 2 x 200mg/day – (over the counter in countries like Belgium, etc.)
  • Metformin – 2 x 500mg/day – (on prescription or online pharmacies)
  • Chloroquine – 200 to 400mg/day – (over the counter – for those traveling to countries with malaria risk)
  • Doxycycline – 200 to 400mg/day – (on prescription or online pharmacies) and or Mebendazole 200mg – 1g/day (this is one of my favorites – over the counter and available on eBay)
  • Omega-3 (EPA and DHA) – 10g-15g/day

Note: The list bellow will be continuously updated and refers to various elements that if used prior or during the chemo sessions may enhance the effectiveness of the chemo.

Update 08.03.2016: Dear All reading this website, based on recent personal experience I suggest that while using chemo the strong anti oxidants (such as Alpha Lipoic Acid, NAC, etc.) shoudl not be used in high dose forms such as Intra Venous. Not even several days after or before chemo as they will clearly protect cancer cells. I know that this  is what the oncologist are saying and many are questioning this statement but now I support 100% that statement. Low dose oral supplements such as Alpha Lipoic Acid may help and support e.g. the liver (so I may still use that?) but high dose will help cancer cells defend the pro oxidant anti cancer effect of chemo or other pro oxidant treatments such as 3BP.

Update 28.05.2018: Here is a very good scientific paper describing each known major point that could influence the effectiveness of chemo: “Resistance to cancer chemotherapy: failure in drug response from ADME to P-gp“.

chemotherapyReducing Side Effects

Reducing Glutathione – Glutathione (GSH) is the most abundant non-enzymatic antioxidant molecule in the cell and is essential for cell survival and redox homeostasis – Glutathione is used by cancer cells to compensate for increase oxidative stress due to treatments such as chemo or radiation

Therefore, during Chemo we need to avoid strong anti oxidants such as IV Alpha Lipoic Acid or NAC supplements. To me that doesn’t mean that we need to avoid food with anti oxidant properties.

“Cancer cells have a high demand for ATP because it provides the ‘fuel’ for aberrant proliferation. However, the dark side of this uncontrolled energy production is the accumulation of ROS, which needs to be counteracted by scavenging mechanisms to ensure cell survival. At high levels, ROS promote cell death and severe cellular damage. Cancer cells need to combat this high levels of ROS. Therefore, cancer cells characteristically have a high antioxidant capacity that regulates ROS to levels that are compatible with cellular biological functions but still higher than in normal cells. We believe that targeting these enhanced antioxidant defence mechanisms may represent a strategy that can specifically kill cancer cells.” (Ref.)

“ROS are broadly defined as oxygen-containing chemical species with reactive properties. These include the superoxide (O2 •−) and hydroxyl (HO• ) free radicals as well as non-radical molecules such as hydrogen peroxide (H2 O2 )” (Ref.)

“Thus, although treatments such as chemotherapy and radiotherapy — which induce the production of ROS — are useful for eliminating the bulk of cancer cells, such approaches may fail to cure the patient owing to the superior ability of cancer stem cells to survive in conditions of high ROS by upregulating levels of antioxidants. As ROS are critical mediators of the lethal effects of ionizing radiation and some anticancer drugs, TICs may be preferentially spared and actively selected by treatments that depend on high ROS levels.” (Ref.)

Reducing acidity around the tumors – most of the tumors are using glucose as one of the main fuels for energy production. During this energy production, acidity (protons) are being produced and continuously pushed out into the tumor environment, via several types of transporters, creating an acidic environment. This environment promotes tumor progression, inhibits the action of the immune system and “deactivates” various chemotheraphies that are weak basis (but is helping the weak acid chemos). Various elements that lead to reduction of acidity around tumors:

Therefore, I would check if the chemo I use is weak basis and if yes I would consider this approach to increase its effectiveness. If on the other hand is weak acid, I would stay away from combing proton pump inhibitors with the chemo.

Reducing Multi Drug Resistence – many cancers can resist chemotheraphy due to specific pumps that are located in the cell membrane and are used to push the drugs out of the cells. These pumps are over expressed in cancer. Various elements that can reduce or inhibit these pumps are:

  • Verapamil (e.g. Ref.)
  • Ketoconazole
    • Note: Coadministration of simvastatin (or lovastatin) with antifungals (itraconazole or ketoconazole) can result in rhabdomyolysis and acute renal failure (Ref.) Simvastatin & lovastatin should therefore not be used concomitantly with itraconazole and other potent CYP3A4 inhibitors, or the dosage of lovastatin should be greatly reduced while using a CYP3A4 inhibitor (Ref.). This increased toxicity is not apparent with fluvastatin (Ref.)
  • Tetrandrine (this is a natural Ca channel inhibitor – cheap – used in China before and during Radiotherapy and Chemo to enhance the effect of the therapies – I very much like it)
  • Mebendazole was recently found to inhibit MDR (Ref.)

Increasing blood flow – tumors usually have leaky blood supply and that limits the chemotheraphy that may reach the tumors. Various elements that can help dilated the vessels are:

Reduce glucose to cancer cells – reducing glucose available will lead to lower energy in the cancer cells available to fight chemotheraphy. Below are a few elements that can help reduce the glucose availability of energy production:

Increase RedOx – chemotheraphy puts constant stress on the cancer cells and there are other theraphies who can further add additional stress next to that:

  • DCA (Dichloroacetate)
  • Scorpion Venom
  • Hyperthermia
  • 3BP
  • Exercise & Oxygen

Inhibiting Autophagy – “Autophagy has dual roles in cancer, acting as both a tumor suppressor by preventing the accumulation of damaged proteins and organelles and as a mechanism of cell survival that can promote the growth of established tumors. Tumor cells activate autophagy in response to cellular stress and/or increased metabolic demands related to rapid cell proliferation. Autophagy-related stress tolerance can enable cell survival by maintaining energy production that can lead to tumor growth and therapeutic resistance. As shown in preclinical models, inhibition of autophagy restored chemosensitivity and enhanced tumor cell death.” (Ref)

Bacteria, Parazites, etc. – Tumors (specifically thos ein the lungs) may be “populated” by bacteria and other parasites that just because of their mostly peripheral location may “absorb” the administrated (chemo) substance which as a result may not reach the tumor in high enough dose. There are various medicines that are both know to posed anti cancer properties and can at the same time address this issue:

Others:

Fasting 2-3 days prior to chemo (or radiation) will also help: Fasting-like diet turns the immune system against cancer https://news.usc.edu/103972/fasting-like-diet-turns-the-immune-system-against-cancer/

See Also: this comment https://www.cancertreatmentsresearch.com/pyrvinium-pamoate/#comment-3065

References:

Modulation of oxidative stress as an anticancer strategy (Ref.) http://www.nature.com/nrd/journal/v12/n12/full/nrd4002.html?message-global=remove

The regulation of oxidative stress is an important factor in both tumour development and responses to anticancer therapies. Many signalling pathways that are linked to tumorigenesis can also regulate the metabolism of reactive oxygen species (ROS) through direct or indirect mechanisms. High ROS levels are generally detrimental to cells, and the redox status of cancer cells usually differs from that of normal cells. Because of metabolic and signalling aberrations, cancer cells exhibit elevated ROS levels. The observation that this is balanced by an increased antioxidant capacity suggests that high ROS levels may constitute a barrier to tumorigenesis. However, ROS can also promote tumour formation by inducing DNA mutations and pro-oncogenic signalling pathways. These contradictory effects have important implications for potential anticancer strategies that aim to modulate levels of ROS. In this Review, we address the controversial role of ROS in tumour development and in responses to anticancer therapies, and elaborate on the idea that targeting the antioxidant capacity of tumour cells can have a positive therapeutic impact.

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

Related Articles


94
Leave a Reply

Please Login to comment
avatar
  Subscribe  
Notify of
Emad
Member
Emad

A little update about my mother :

like I said before , she was on Taxotere 160mg (every 3 weeks) + DCA , after 4 months the tumor markers went from 2000 to 350

then she took Taxotere 160mg only with no DCA , after 2 months the markers became 745 (that was on Feb 16)

on (Feb,17) she took another shot of (Taxotere 160mg) , there is still no DCA , only Taxotere alone

but I decided to add other things , on (Feb,22) I add the following :-

Lansoprazol 60mg , HydroxyChloroquine 400mg , Cimetidine 800mg , Metformin 1g , Paracetamol 2g , Sulfasalazine 2g , Mebendazol 200mg , Aspirine 100mg
(I gave them on low doses at the beginning then increased it gradually)

Today : tumor marker CA 15-3 is : 712 ! (slight decrease) the oncologist didn’t expect that !

i think she (the oncologist) is wondering how Taxotere was not working and effective at all then suddenly it shows some little effect !

now what do you think about this result 😀

Helga
Member

Dear Emad,

I was reading your old message today and was wondering if Taxotere-resistance can be overcome one way or another. I am not sure how relevant this is to you and your mom now but I found this: “Resveratrol chemosensitizes HER-2-overexpressing breast cancer cells to docetaxel chemoresistance by inhibiting docetaxel-mediated activation of HER-2–Akt axis” http://www.nature.com/articles/cddiscovery201561

It is quite remarkable also because resveratrol is a natural product. Also: “Docetaxel and resveratrol exerts synergistic cytotoxic effect in breast cancer cells, while normal immortalized breast epithelial cells are unaffected” – I wonder of Taxotere (Docetaxel) is used in other cancers than that of the breast?

It seems that this synergy is not limited to breast cancer: https://www.ncbi.nlm.nih.gov/pubmed/22011009 “Resveratrol enhances the cytotoxic profile of docetaxel and doxorubicin in solid tumour cell lines in vitro.” It might be important because resveratrol is an antioxidant, still it works synergistically with these two chemos.

Emad
Member
Emad

Hi Helga , how you are fine today 🙂

my mother is on Gemzar + Carboplatin for months ago , she is no more taking Taxotere

but I really remember how the results were great when she were taking high amounts of black grapes (eating and juicing) , what I know is that black grapes are one of the best natural source of resveratrol , also she was taking a lot of things including DCA but those results were more better than Taxotere and DCA alone

Emad
Member
Emad

I meant: hope you are fine, sorry for wrong typo

Emad
Member
Emad

yes its a good result for only 10 days !
about paracetamol , its not used every day but that’s the problem I’m afraid of the toxicity of these drugs
can you suggest to me which of these drugs are less useful ? or which of them are more likely to cause toxicity ?
i didn’t like to use all of them , but DCA will take some time to arrive so i don’t have another choice to help the chemo effectiveness
———
for now looks like we are confused , the oncologist suggest one of these choices : continue on Taxotere , or change to vinorelbine !
personally it doesn’t matter which chemo we gonna use
it will be Chemo + DCA + Escozul ,
I’m thinking about adding other strong treatments :
3-BromoPyrovate ?
or maybe Diflunisal IV ?
but I’m not sure will it be a good idea to use Diflunisal ? i heard from Dr.Nolting (from Hallwang Private Oncology clinic) that it may cause bleeding from the colon ? i don’t know if its true or not
Salinomycin is very expensive we can’t get it right now
a lot of options , i don’t know from where to start

Emad
Member
Emad

Thank you so much Daniel , I agree with you 100%

I will continue on all these drugs (with lowering the dose of paracetamol) , and soon I will receive both DCA and Escozul

the oncologist will change from Taxotere to ( Vinorelbine + 5-Fluorouracil )

I hope all these medications will give us a very good response , and in the near future I will add Salinomycin Sodium Salt or Diflunisal

that’s for now , I will continue sharing any results , thanks a lot my friend 🙂

Carl
Member
Carl

What are your thoughts on how to best achieve COX inhibition and antiplatelet effect? Aspirin and/or Dipyridamole? Or a combination with Celebrex, Nattokinase etc. What doses are safe?

Carl
Member
Carl

http://www.medicalnewstoday.com/releases/312121.php

“Immunotherapy to stimulate the body’s immune system has increasingly become the way we treat people with aggressive cancers. It’s effective for a subset of patients, but the truth is that only about 20 to 40 percent of patients will respond to the treatment, and it is still unclear why,”

“It’s a huge question in the cancer immunotherapy field, and we think we’ve found a big part of the answer.”

“Dr. Delgoffe is partnering with other scientists to test various mitochondria-boosting strategies, including using drugs that already have proven safe in humans, such as those for type 2 diabetes…”

Is it Metformin he is refering to? Metformin certainly affects the mitochondria…

ovidiu
Member

There is a synergy between metformin and dichloroacetate in several cancer cell lines, which could be translated into therapy.

Sensitization of metformin-cytotoxicity by dichloroacetate via reprogramming glucose metabolism in cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/24480191
Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/25212175
Dichloroacetate and metformin synergistically suppress the growth of ovarian cancer cells.
http://www.ncbi.nlm.nih.gov/pubmed/27449090

ovidiu
Member

There is more, according to this article, it is very important to inhibit HIF-1a in order to get DCA + Metformin efficacy.
Targeting HIF-1α is a prerequisite for cell sensitivity to dichloroacetate (DCA) and metformin.
http://www.ncbi.nlm.nih.gov/pubmed/26616058

There are many compounds that inhibit HIF-1a, with more or less clinical effectiveness, I list a couple.
Potent inhibition of tumoral hypoxia-inducible factor 1alpha by albendazole.
http://www.ncbi.nlm.nih.gov/pubmed/20398289
Noscapine sensitizes chemoresistant ovarian cancer cells to cisplatin through inhibition of HIF-1α.
http://www.ncbi.nlm.nih.gov/pubmed/21421285

By searching for mebendazole and hypoxia, I found something interesting.
Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin.
http://www.ncbi.nlm.nih.gov/pubmed/24766300
So it appears that albendazole and mebendazole are HIF activators in normal cells, at least in neurons.
This needs further investigation, to find out the effects of mebendazole – with respect to HIF-1a – on various cancer lines, normal cells, and tumoral stromal cells.
In the article there is a list of drugs that induce HIF, and probably should be avoided during chemo, unless they are proven to act the opposite way in cancer cells.

Meech
Member

Hi Daniel,

You mentioned bacteria and parasites as inhibiting the activity or chemo. Would you then advise against things like probiotics or fermented drinks (kefir, yogurt, etc).

You also mentioned increasing blood flow to the tumour(s); would you advise against anti-angiogenic therapies for the duration of chemo?

Alex
Member

Dear friends.
So if metformin fails, try with diclofenac or resveratrol?
Sorry i don’t have the science knoledge yet to understand the conversation, looking for a more clear view.

Good Luck,
Alex

Helga
Member

Dear Daniel & All,

I tried to post a msg but cannot go through. The most important msg is that resveratrol seems to work synergistically with chemo even though it is a strong antioxidant. See this: http://www.nature.com/articles/cddiscovery201561 and this: https://www.ncbi.nlm.nih.gov/pubmed/22011009

Helga
Member

Here is a very interesting article about combining a polyphenol (like resveratrol) and a chemo. Quite often they work synergistically, NFKB downregulated (suppressed). NFKB is a central gene in cancer, usually overexpressed.

https://www.researchgate.net/profile/Aarti_Mohan2/publication/227855952_Combinations_of_Plant_Polyphenols_Anti-Cancer_Molecules_A_Novel_Treatment_Strategy_for_Cancer_Chemotherapy/links/56d51a8d08ae2cd682b94641.pdf
“Interestingly, curcumin has also been reported to cause apoptosis by
generation of reactive oxygen species (ROS) causing the release of
Endo–G (endonuclease G) and apoptosis inducing factor (AIF) into
the nucleus and cytosol which in turn causes DNA fragmentation
and chromatin condensation [68]. This phenomenon where the
same molecule has been reported to exhibit anti–oxidant activity in
certain cases and pro–oxidant behaviour in certain others has been a
subject of much debate in the research world. This phenomenon is
now referred to as the “antioxidant paradox” and is reported to be
primarily influenced by concentration of the molecule but may also
involve other pathways that are yet to be explored. ”

There is a big table showing several combinations and their effect on cancer (cells). I find this important because Daniel writes somewhere that it is important not to use certain antioxidants while having chemo. While that may be true of the molecules he mentions, it looks like using polyphenols is beneficial and synergistic.

Alex
Member

So maybe there is some help from getting the 5 drops of resveratrol extract under the tonge like we are doing?
I got some drops under the tongue myself just to see how it feels, it felt good, like in 5 minutes i started to feel my joints less stiff, the rest of the body felt like i took diclofenac.
I managed to get some grain sprouts today for mother as suggested.
Yesterday mother had migranes, gave her a bit of chocolate and that went well for her. (low blood sugar levels)
Today i notice the bump or her arm became softer again. And mother is feeling better. This could be the effect of what went on yesterday but it may also be an advantage, a clear indication of success or failure, or maybe not.
DCA arrived today, feeling optimistic and wish to thank again for the much much help received.

THANK YOU! HUGGS!
Alex

Ergin
Member
Ergin

Dear Daniel,
There are some glyco inhibitors which we didnt talk before.
They are working on another mechanism different than insuline or metformin.
They can be easily reachable.They are working like Phlorizin in your post.(SGLT inhibitor)

Mechanism of action
Canagliflozin is an inhibitor of subtype 2 sodium-glucose transport proteins (SGLT2), which is responsible for at least 90% of renal glucose reabsorption (SGLT1 being responsible for the remaining 10%). Blocking this transporter causes up to 119 grams of blood glucose per day to be eliminated through the urine,[15] corresponding to 476 kilocalories. Additional water is eliminated by osmotic diuresis, resulting in a lowering of blood pressure.

This mechanism is associated with a low risk of hypoglycaemia (too low blood glucose) compared to other types of anti-diabetic drugs such as sulfonylurea derivatives and insulin.[16]

I am very sure that it will enhance chemo effectiveness,but dosage?protocol?
I wonder your thoughts about SGLT inhibitors.
Kind Regards
Ergin

Alex
Member

how about Phlorizin+Metformin?

Alex
Member

With my mother’s situation deteriorating from day to day.
She felt it would be best if someone more competent will lead they way, aka the oncologist.
She will go with chemo maybe starting monday.
We are feeling very bad.

Emad
Member
Emad

Why not you see the results on CT Scan before anyone decide what to do ?

Alex
Member

Sadly she’s unable to walk, a scanner is not available in the “hospital” here.
There is a sense of urgency.
Will try to at least get markers done

Alex
Member

Advice needed from personal experience on what to do, buy, get, say etc when dealing with chemo treatment.
Many many thanks.
Alex

Emad
Member
Emad

for me with our limited financial capabilities , I can only focus on making treatment more effective , sadly I can’t focus on what protects the body from chemo

the only good thing is if the patient can drink juices and eat healthy food while on chemo

the goal is to shrink cancer until no more chemo needed

but as soon as you stop chemo you need to find another working drug

for me I want to start my mother on MG when she no more needs chemo , as its not expensive and it can be given orally

but really Alex you should not talk about chemo right now , CT Scan or MRI should done first , you have to find it and do it so you can know whats really going on and whether your mother needs chemo or not

hope you don’t need it at all

Alex
Member

i may be able to help with ordering something for your mother. let me know…. i’m in the fight as well, more away from the computer and out to the oncology hospital here.
Waiting for blood tests, markers, scan, it will take a few days.
Looks like the tumor is pressing against the spine cord more and more.
I don’t know where we’ll go from here, surgery, chemo, none?
I may need 3bp, sal as well.
It’s a nightmare and we all know it.
Mosquitoes in the hospital are pottentialy spreading and mixing the disease to other sick ones or healty.
Oncologist gave her the IV version of the vitamins we were doing at home LOL, except for glucose and cortizole.
Too much suffering…. it’s not fair. Too many tears
Thank you very much
Alex

Wondering
Guest
Wondering

hi Alex
i would ask doctors about egfr inhibitors. again, these inhibitors are like chemo light. Gene inhibitors are not like Cisplatin or Vincristine..like the big guns. Your dear mother could take it, side effects are not brutal.
wishing you all the best.
W

Alex
Member

we’re going to do some testing on the original tumor tissue samples the hospital kept. We may be lucky on that.
best wishes
Alex

Emad
Member
Emad

Hope there is nothing scary when the scan results show up

thanks also for your willing to help , please focus on your mother treatment , I will be fine

sorry to hear about these problems in the hospital , it sounds like our poor hospitals unfortunately

regarding 3bp and sal , like I said before , you can have them once you have an email related to any university , its not hard I think , the other thing is to have a medical port placed on the patients chest , which is also available in any country and can be done in a small surgical procedure

or if you have to buy some time you can focus on things like MG or T4 depletion or any other treatment that may work and easy to administrate orally

stay strong , I believe you will feel better soon , I will pray for that

Your friend Emad

Alex
Member

i don’t know what to do to decrease tumor size on the spine without causing further damage, oxidative, nerve cells etc.

Emad
Member
Emad

can you give more details about the scan results ?

what did change for the last months ?

Helga
Member

Dear Alex,

This might interest you too:
“9. Spinal cancer, ozone sauna
“Diagnosed with a rare spinal cancer in 1998. Her oncologist advised her to go to a local University cancer clinic for some radical new chemo treatments.
Within six months, she was bedridden, her cancer-riddled spine unable to support the weight of her head, losing weight rapidly, deathly ill from the toxic drugs they gave her. She left there on a stretcher, advised to put her affairs in order.
A friend of hers called me up and asked what could be done. Since I knew someone who lived near her, who had an ozona sauna, I connected them, and the ozone sauna ended up at DY’s place for six months. During that time, she gave herself daily ozone saunas (at first with considerable help from friends), did liver cleanses, ate fresh organic food and several varities of oriental mushrooms.
Within six months, she could walk unassisted, hold her head upright, and had begun an exercise program. Now, three years later, she is free of cancer, and will be opening an ozone sauna clinic of her own in the spring. “

http://thepowerofozone.com/116-reports-of-cancer-successfully-treated-with-ozone-therapy/

See if you can locate an ozone sauna or ozone machine nearby! How is your mom doing?

Kind regards,
Helga

Helga
Member
Alex
Member

Thank you very much dear Helga,
If it wasn’t for you this place would have been a lot poorer in information.
My mother is in a very bad shape, we need a neurosurgeon for her spine leftover tumor that has invaded the nervous system there and is pressing against it. ( so says the oncologist ).
The oncologist delayed everything for insurance money sake i think…… now she is saying there’s nothing that she can suggest, not even a neurosurgeon. I need an ambulance to take my mother to another hospital and that depends on her to give us one but only after i talk to a neurosurgeon that will accept my mother there.
A big system that is meant to fail one day…. meanwhile…. more problems.
Once i see my mother on her own feet, i’ll take her to a sauna for sure. And should we see no more tumor on her nervous system, we’ll probably continue with DCA and others because we feel they did work.
But for now we must deal with the paralisys, she’s unable to get out of bed at all. I had to order more DCA anyway… but not now.
I’ll probably be away from here for a while…. someone up there loves me and my mother extremely much…..
Cancer is not enough, there had to be complications too….
So far we’ve been lucky enough in so many ways, i can only hope this time luck will favor us despite the extreme love received from up there.
Let me know how things are going with you and your mother, ill read when i get the chance.
Best wishes.
Warm hugs
Alex

Helga
Member

Dear Alex,

so sorry to hear all about the tears and suffering. I suggested somewhere else but raise it here too: how about applying Diclofenac & heparin (both available in ointment, e.g. Voltaren+Lioton) locally? The tumor being near the spine must be fairly close to the skin so I imagine it could help somewhat. I used Lioton locally and it seemed to help me. Heparin should be able to work transdermally! Also, you could try to add DMSO to them.

Best wishes,
Helga

anca
Member

Alex,
Îmi pare rău pentru situația mamei tale. Sper sa se îmbunătățească starea ei.

Alex
Member

multumesc, momentan nu stiu cum sa fac sa reduc tumora fara inflamatie pentru a elibera presiunea de pe maduva.
Se pare ca avem nevoie de un neurochirurg capabil sa opereze pe coloana/maduva.
Fostul neurochirurg a dat birul cu fugitii, raspunde la numere straine dar la al nostru nu. Cred ca ii este frica de ceva.
DCA pare sa fi functionat in cazul nostru dar daca a facut asta este posibil sa fi cauzat si inflamatie, oxidare neuro-celulara am vazut si un raspuns imunitar.
Doctora oncoloaga NU este interesata de nimic de genul.
Tot doctora oncoloaga spune ca nu se poate intervenii decat chirurgical.
Daca nu gasesc un doctor sau o echipa de doctori, este improbabil sa facem rost de o suma de genul 500 milioane pentru o astfel de interventie la privat.
Legat de markeri unul din ei a scazut putin, insa markerii sunt si deceptivi din pacate.
In concluzie am ajuns la parerea ca sunt mai bune tratamentele agresive temporare, 1-3 zile si apoi pauza pentru recuperare.
Tratamentele pe termen lung au efecte mai adverse, insa aceasta agresivitate trebuie supravegheata de doctori calificati care din pacate de foarte multe ori nici nu vor sa auda de alternative or chiar anexe la ceea ce se considera a fi standardul de aur.
Si in situatii unde e vorba de complicatii majore, e foarte recomandat sa se evite inflamatia sau stresul oxidativ, lucru greu de facut dupa cum se pare.
Dupa ultimul CT insa, realizez importanta si impactul major al lucrurilor pe care le-am facut, dieta, strategie si speranta.
Daca nu faceam ce am facut, lucrurile ar fi fost mult mai grave de mult cu certitudine.
Eu sunt efectiv la pamant cu tot. Nervi, energie, speranta, si probabil in curand si cu banii.
Insa am ambitie si perseverez, realizez insa ca probabil nu o sa fie suficient. E o lupta pe prea multe fronturi.
Sper din suflet ca ai mai multa bafta.
Cu mult drag,
Alex

anca
Member

Buna Alex,

Sper sa gasesti un doctor neurochirug care sa opereze pe coloana, la Fundeni sunt doctori foarte buni, ma interesez si daca aud de cineva iti scriu. De asemena, mai este si varianta Cluj in cazul in care nu accepta nimeni in Bucuresti, o doamna pe care nu au avut curajul sa o mai opereze la Bucuresti pentru cancerul ovarian avansat, s-a operat la Cluj dupa ce a facut in prealabil chimioterapie, era foarte grav, o tumoare de 7 cm, markerul CA-125 de 2300, dar a avut noroc ca a facut chimioterapie inainte de operatie pentru diminuarea tumorilor, si nici pana acum la un an dupa, nu a recidivat. Mama mea a avut cancerul mai putin avansat, dar pentru ca nu a facut chimioterapie inainte de operatie care sa ii “distruga” tumorile, operatia a fost mult mai grea, acum are recidiva. De aceea medicii ar trebui sa schimbe protocolul care spune ca operatia se face inainte de chimioterapie, cel putin la cancerul ovarian, ultime studii arata ca e mai benefic cu chimioterapia inainte.

Daca mai ai DCA in plus si vrei sa imi vinzi sau stii pe cineva care are sa imi spui, as dori sa incep sa ii dau si eu mamei si am auzit ca dureaza cateva saptamani pana ajunge din strainatate.

Sa pastrezi ambitia si perseverenta si o atitudinte pozitiva, pentru ca e extrem de important psihicul in lupta cu cancerul. EU voi lucra si cu o persoana care sa ii dea mamei energie, deoarece se simte mult mai bine cand are energie.
Sanatate mamei tale,
Cu drag,
Anca

Ergin
Member
Ergin

Dear Anca,
What I only understand from your message is CA125:2300.
That means there is a huge ascite in the abdomen.You have to use a VEGF inhibitor.It is highly effective on ascites but not on periton.
Please work on Thalidomide and Dr Hada’s protocol.I am almost sure that will work.
Kind Regards
Ergin

anca
Member

Hi Ergin,
Thak you very much for writing to me. I wrote all these substances that my help for my mom’s oncologyst and she will search information about them, abuut DCA and some others.
I wrote above that in 2015 there was a lady diagnosed with ovarian cancer, twice operated for bowel obstruction in a week, and she had a big tumor of 7 cm and CA 125 of 2300 and the doctors didn’t want to remove her tumor, they didn’t have the courage, so she had chemotherapy sessions and after the tumors had been destroyed she found a doctor in another city in Romania, Cluj, who did the surgery, which was not so complicated because all the tumors were killed except a small one and that woman is in good shape now after one year in remission, my mother was in the same hospital with ovarian cancer in Seoptember 2015 with CA-125 of 700 and a tumor of 2 cm and the doctor did the surgery straight away and also cut a part from my mother’s colon, then after 6 months they put the colon back so my mom got rid of the colonostomy bag in 2016, and in December 2016 my mother had a recurrence of the ovarian cancer, which is very hard to treat. So that lady who had a more avanced ovarian cancer is healthy now because she had chemotherapy first, and then surgery, and my mother is suffering again. So I said the doctors should change the protocol and do the chemotherapy first and then surgery and then 3 more sessions of chemotherapy, because the newer research articles say that it is a better prognosis if they do the chemotherapy first then surgery in ovarian cancer.
My mother has a CA-125 of 1890, which is high. But her blood analysis is very good, she has good blood sugar and all the rest, my mom is feeling good and that gives me hope. My mother is working with a therapist who is religious and is energising her by speaking with my mom on the phone for a few hours after chemotherapy and totally changed my mother’s state in good, she is optimistic again, she has energy, she cand walk, cook, a few weeks ago my mother had no energy. So I think God can help my mother heal. If your mother believes in God and her faith can help her heal.
We don’t do anything if the doctor doesn’t approve, and I will see tomorrow what the doctor wants to use for my mother. She had today a session of chemotherapy with Caelix and yesterday Vitamin C IV. I also gave her Metformin.
If we use Thalidomide, can you tell me how much it costs in Turkey? Maybe I will buy from your country.

I hope your mom is doing well and wish all the best to her,
Anca

Ergin
Member
Ergin

Hi Anca,
Thanks for the msg.In theory and upto statistics,first surgery and then chemo gives more benefit for Ovarian cancer.
Less tumor more benefit from chemo.
I wonder if they have looked for Gemzar effectiveness on that test for your mother.
Did you send blood or biopsy or she went to Greece for test?
Could you please give me the contact details of lab.
Unfortunately thalidomide is not sold here.I found it in Bulgaria with a price of nearly 500 euros for 28×50 mg.
You can buy it from Mexico with Daniel’s help but can you take it from customs?
Is there any tumor on periton of your mother?Does she have bad bowel syndromes?And what about ascites?
Kind Regards
Ergin

anca
Member

Hi Ergin,

I can give you the e-mail address of the clinic in Greece where they do the cancer test, RGCC Medical e-mail is: [email protected]. You can write to them, the test that my mom did is Onconomics and we payed around 2500 euros. We took blood 7 days after the last chemotherapy and sent the blood to Greece for the test, the results came after 10 days. The test is detailed, there are 12 pages with what chemotherapies my mother might be sensitive to, and in the last page we have some conclusions, I can paste them here:
“From the investigation above we concluded to the following:
1. From the whole neoplasmic population we have an expression of MDR1 in a percentage of 60% over control sample
(positive in the check of resistance).
2. The activity of GST is stable in the low limits (no resistance to platinum compounds).
3. The activity of GammaGC is in normal range (no resistance to platinum compounds).
4. The activity of CES1 and CES2 is in low limits (no resistance to camptothecin compounds).
5. The concentration of p180 is in normal range.
6. Increased activity of the Laminin and the MMP (increased invasive ability).
7. There is partial sensitivity in taxanes (Paclitaxel, Docetaxel, Cabazitaxel).
8. There is no sensitivity in alkaloids of vinca.
9. There is no sensitivity in Eribulin.
10. Partial sensitivity noticed in MTX, in Gemcitabine, but no sensitivity noticed in 5FU, in Capecitabine, in Fudr, in UFT, in
Raltitrexed, in Pemetrexed, in Cytarabine, in Fludarabine
11. There is no sensitivity in Epothilones.
12. Increased sensitivity in alkylating factors (Νedaplatin).
13. There is great overexpression of EGF (45% over control), TGF-b (35% over control), but there is normal expression of
IkB(a, b, c), NFkB.
14. It appears to have great sensitivity in the inhibitors of topoisomerase II (Liposomal Doxorubicin).
15. There is no sensitivity in the inhibitors of Topoisomerase I.
16. There is great over-expression of COX2 (10% over control), C-erb-B1 (55% over control), but there is normal expression
of 5-LOX, SS-r, C-erb-B2, Estrogen-Receptor, Progesterone-Receptor.
17. We notice great neoangiogenetic ability (overexpression of VEGF-R 55% over control sample).
18. Finally, there is no sensitivity in Dacarbazine.
19. We notice that taurolidine cannot induce the apoptosis to the malignant cells (in IV route dosage).
20. We notice that taurolidine can induce the apoptosis to the malignant cells (in intraperitoneal route dosage).
21. We notice no down-regulation of HSP72 (Heat Shock Protein), but we notice down-regulation of HSP27 (Heat Shock
Protein) at 15% below control, HSP90 (Heat Shock Protein) at 10% below control.
22. There is over-expression of ANG 1 at 30% over control, ANG 2 at 25% over control, IGF-r 2 at 15% over control, but we
notice no down-regulation of ALK, EML-4-ALK, C-MET, NPM-ALK, CD 117 (c-kit), IGF-r 1, HDAC, HAT, NR3C4-
A, NR3C4-B.
Conclusion:
 The specific tumor appears to have resisting populations because of the MDR1 overexpression that can be reversed by the
use of inhibitors of ABCG2 pumps.
 The neoplasmatic cells have the greatest sensitivity in the alkylating agent (Νedaplatin), in the inhibitors of
Topoisomerase II (Liposomal Doxorubicin)
 Also can be used Bevacizumab as inhibitor of neo-angiogenesis, Ramucirumab as an inhibitor of VEGFR2, ZivAflibercept
as an inhibitor of VEGF as inhibitor.”

Based on the test, my mother is doing Caelix now IV. My mother has some tumors in the peritoneum, the biggest one was 4 cm large in April, but now it could be bigger.
I hope it helps you.
Kind regards,
Anca

Alex
Member

Multumesc foarte mult Anca.
Cand am fost la fundeni, si nu era asa complicat ca acum, ne-au trimis la spitalul militar, iar acolo a trebuit sa vorbim cu seful de sectie care a fost singurul neurochirug sa accepte “provocarea”. Desi nu s-a lucrat pe maduva, conform cunostintelor mele si scanarilor ulterioare dar si efectul vazut azi. Paralizie.
Legat de chimioterapie inainte de operatie, mama este slabita rau, iar oncoloaga a spus ca nu face ca nu ar fi util in cazul ei la maduva, de radioterapie nici nu se mai pune problema.
Noi am continua DCA dar este inoportun acum din mai multe motive. Aparent a functionat pana cand a aparut aceasta complicatie.
Legat de vandut DCA, ti-as trimite gratuit, nu ca nu am nevoie de bani dar un DCA as putea si eu sa trimit asa cum si mie mi s-a oferit ajutor, asa vreau si eu sa ajut. Insa mai am doar o parte dintr-un flacon.
Te avertizez insa ca daca functioneaza efectul este oxidativ si in functie de locatia bolii pot aparea complicatii, inflamatii, edem, marire de organ etc. Si alte efecte secundare descrise pe aici. Tind sa cred ca efectul oxidativ nu este limitat strict asupra tumorii si oxidarea celulelor invecinate are din pacate consecinte mai mult sau mai putin serioase in functie de locatie. In cazul nostru pe maduva unde….. ce sa zic ma iubeste cineva sus acolo mult de tot, are o dragoste enorma pentru mine si mama mea. 🙁
Iti pot trimite ceea ce mai am in flacon, insa nu stiu cand ca maine trebuie sa plec la bucuresti sa caut doctori si apoi daca gasesc raman pe acolo cu mama.
Iar acum e ora 23, trebuie sa luam legatura, cu toata bunavointa cred ca e posibil sa ajunga mai repede din strainatate decat pot eu sa trimit fiind in situatia asta foarte dificila.
Intre timp cred ca ar fi buna o dieta vegana raw, nu neaparat stricta, cu carne alba, fiarta, la gril, fara uleiuri, fara paine, lapte, zahar, sucuri etc.
Pentru energie, sucuri naturale facute acasa, fara miere, iar pentru energie, un energizant odata la 3-4 zile nu e tocmai rau.
Clismele cu cafea au fost benefice in cazul nostru, facute ocazional.
Metformin, aspirina, diclofenac, lansoprazol astea sa nu lipseasca din casa cred.
Ar fi bine sa luam legatura cumva, skype, telefon insa din pacate sunt prins aiurea de tot acum.
Snake_Systems sunt eu pe skype. online mereu, dar nu la pc pentru ca ….. probleme multe.
Cu mult drag,
Alex

anca
Member

Thank you, Alex. I hope your mother is ok and you found a doctor for her.
My mother is doing chemotherapy with Caelix and also Vit C IV.
We don’t use anything if the doctor doesn’t approve, so she has to read and will tell us tomorrow if DCA is good for my mother. After reading all the side-effect that you wrote, I honestly don’t know if we should use DCA. My mother doesn’t have the courage to test new things on her body. My mother is eating what she can, I don’t think she she can eat raw vegan, but she cut sugar completely and all unhealthy and unnatural stuff.
I also gave my mother Metformin. My mother believes God will heal her, she is working with a person who helps her psychologically, and that changed my mother state in good and gave her energy.
I live in Bucharest, I don’t know if I need DCA now, we see tomorrow what the doctor say. Thank you for offering me what you have.
How is your mother doing?

Helga
Member

Dear Ergin,

Anca talks about someone else, who had chemo before surgery and that made her surgery more successful than her mom’s who, on the other hand didn’t have chemo before surgery.

By the way, you were right about me, I had an exam today with ultrasound and the doc said my ovary is quite small so she does not think I have ovarian cancer. She recommended mammogram just as routine but I had it only once and swore never to have it again. Thermography is a much safer and more pleasant option but the mammographic machine producers apparently

Ergin
Member
Ergin

HAHA Helga it is a very good news.I am very happy to learn that you are not cancer.
But please dont leave us!
Best wishes
Ergin

Helga
Member

Hi Ergin,

no, I won’t leave, don’t worry. I am very interested in following your and other people’s updates and try to help, if I can. Sorry to hear that your mom is weak. Do you think you could try the ozone treatment? Intravenous ozone is very good, too. I had several sessions last year and it helped a lot with my fatigue. Here you can’t have it if you have cancer. But maybe you can in Turkey. Intravenous vit C is the same, it works as a pro-oxidant if given intravenously.

Best,
Helga

Meech
Member

Ive had percutaneous ozone from a fairly sketchy doctor. I had it for neuropathic pain. The injections were painful for a few minutes and then subsided.

I can’t say if it helped but in the moment I felt as though it did.

Ergin
Member
Ergin

I am very interested in intraperitoneal drug delivery.Lots of drugs works for cancer on pertion by ip but not iv nor oral.
We have very good knowledge in this website about effective drugs but some of them doesnt reach to tumors.
For example Pyrivinium Pamoate.It has zero effect on everywhere except colon or stomach.
If i can find a brave doctor who is experienced about ip delivery,i will directly get into contact with him/her.
And what i wonder is, if patients have palpable tumors why they dont use these drugs as directly injected to tumors.
Does it cause stg bad?Like bleeding or stg else?

Meech
Member

Sorry i meant subcutaneous, so only a little under the skin, not far enough to reach a tumour.

I have wondered the same thing though. I’m wondering how well the drug would be contained within that tumour if it was directly injected.

Helga
Member

Ah, goody, I posted that. So apparently they lobbied more successfully for their machines to be used with insurance coverage, despite being more harmful than thermograms. We all should lobby for that safer option! I read somewhere that women who get more mammograms get more breast cancer! Mammogram can hurt the breast tissue for sure as they press on the breasts so hard that they are turned into pancakes temporarily. It is well known that breast tissue injury can later cause breast cancer (even though my doc denied it).

How is your mom doing?

Best wishes,
Helga

Ergin
Member
Ergin

Thanks for asking mom.She is weak vomiting etc after carboplatin.
Tomorrow adrenalin day.Blood counts!

Emad
Member
Emad

sorry to hear that Ergin , my heart is with her

how is the results ?

Carl
Member
Carl

Hi Alex,
Perhaps EBC-46, extracted from Blushwood tree, is worth looking into. It has shown some promise in sub-cutaneous tumours that the substance can be injected direclty into.

http://www.dailymail.co.uk/news/article-2785903/A-cancer-fighting-berry-tree-ONLY-grows-far-North-Queensland-human-trials-approved.html
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4182759/

Wishing you and your mother all the best!
Regards,
Carl

Ergin
Member
Ergin

Very interesting Carl,thanks for sharing.I was just searching for direct injections of drugs to tumors.
May be it can be used intraperitoneally also.

Ergin
Member
Ergin

Dear Daniel,
I have a question for varapamil which you wrote in top of this page.
Which one do we have to choose?
A drug for lowering the denstity of tumor vessels or a drug to enhance the tumor vessels for drug delivery into tumors?
Or on chemo days enhance vessels for drug delivery,other days using an anti-angiogenic drug?
I am sure the answer is somewhere in this website but i couldnt find.

”Increasing chemotherapy delivery to tumors, while enhancing drug uptake and reducing side effects, is a primary goal of cancer research. In mouse and human cancer models in vivo, we show that coadministration of low-dose Cilengitide and Verapamil increases tumor angiogenesis, leakiness, blood flow, and Gemcitabine delivery. This approach reduces tumor growth, metastasis, and minimizes side effects while extending survival. At a molecular level, this strategy alters Gemcitabine transporter and metabolizing enzyme expression levels, enhancing the potency of Gemcitabine within tumor cells in vivo and in vitro. Thus, the dual action of low-dose Cilengitide, in vessels and tumor cells, improves chemotherapy efficacy. Overall, our data demonstrate that vascular promotion therapy is a means to improve cancer treatment.”
http://www.sciencedirect.com/science/article/pii/S153561081400419X
Kind Regards
Ergin

Alex
Member

Hello!
Had to take my mom to the oncologist/hospital because she couldn’t walk anymore or get out of bed. – CT/MRI show the tumor invading the spine and causing paralysis aggressively – Doc say it’s permanent.
My dear mom is doing Carboplatin
Before that she was on Vitamins like B1, B6, B12, electrolites, and diuretics but also bisphosphonates.
Help!?
Thank you very much!
My best wishes to you all,
Alex

Wondering
Guest
Wondering

I am sad to read these news.
I know that in theory Cisplatin increases the effect of cisplatin. Maybe worth continuing with that.

Emad
Member
Emad

Sorry to hear that Alex

how is your mother now after carboplatin ?

give us updates on her condition

also , how doctor can make sure this paralysis is permanent ?

maybe its sounds crazy but we all at the beginning thought that advanced cancer is a death sentence , which we now believe that its not , and there is something we can do about it

also who knows if its not possible to regain health and overcome paralysis which may not be permanent ?

I suggest to focus now on cancer , try to do whatever you can to shrink the tumors , especially the tumor that is invading the spine

after that you can focus on the damage done to the nerves and see if there is something you can do about it

you should not let those side problems make you feel weak and stressful

always wish the best to you

Wondering
Guest
Wondering

hi Alex,
they say that with severe nerve damage if they can’t help you in 24 hours (surgery, superintense chemo, radiation) the paralysis is always permanent. Even if the tumor gets smaller Spinal cord is unable to restructure itself – its not like the brain. There are ongoing studies though and some compounds seem to help but…there is no real solution yet. Still, i agree Alex and Mo should not give up yet.

Wondering
Guest
Wondering

sorry, meant that to Emad..

Alex
Member

Thank you very much Wondering.
I highly appreciate your support and comments always.
Without you this family here would have been a lot smaller.
And i mean to say you’re a big and meaningful part of it.
I wish to thank you personally for absolutely everything.
Stay strong man, we need you. Everyone does.
Do your best not to loose yourself, i know i should try harder too.
If things weren’t so hard with my mother being paralized an maybe having some actual help around i would have had more time to give here. I hope one day things will get better,
Till then,
Please take care!
Alex

Wondering
Guest
Wondering

Hi Alex,

thanks a lot for your kind words.

I am sure your dear mother is aware of what a caring son he has. by the way i read that with a spine met the average survival time is 6 month, for her it has been a lot more and she is still with you. believe that the things you did helped her to be still here. Of course no one can prove it but it is very likely.

i wish you strength and luck …

Alex
Member

Thank you very much wondering.
The spine thing is not a “distant” metastasis, its more of an invasion from the lung.
The original tumor is said according to the post-surgery biopsy that it started from the lung/outside of it and then invaded the spine bones/nerves and now the cord.
Indeed it sounds like we did great compared to statistics. Still we hope for more 🙂

Alex
Member

Thank you very much for everything.
I hear of people recovering from very similar situations so we still hope and try our best to fight.
She can’t move any muscle bellow her chest, involuntary movements in her legs. Burning sensations, cold feet, difficult to caugh, pain in her chest/bone/spine/back on left side, tumor on right?! MRI shows swell in spine medular channel and tumor invading from outside in the swell.
I hope your mother and you are doing better?!
Best wishes,
Alex

Carl
Member
siven01@yahoo.com
Member

Hi ,
I would like to find out from you what is the opinion regarding vitamin C IV and ozonotherapy IV, in relation to the title of the article, whether it helps or not during chemotherapy? I personally did not find any study but only opinions (came from some naturopaths)

Jcancom
Member

siven01, these might help.

The second url speaks to the shared frustration that so much of science has not embraced a more systematic methodology.
As noted below even after 60 years of vitamin C cancer treatment, an optimized treatment protocol has yet to emerge.
However, cancer treatment, at least in children, became much more effective when such optimized protocols were created.

https://www.isom.ca/article/increasing-the-effectiveness-of-intravenous-vitamin-c-as-an-anticancer-agent/
https://www.isom.ca/article/editorial-how-can-we-advance-the-clinical-application-of-intravenous-vitamin-c-among-patients-with-cancer/