Good News from Marcos

During this holiday, I was very happy to read good news from Marcos (a visitor of this website) regarding the treatment outcomes of his wife, suffering from stage IV endometrial cancer.

Here is a short summary extracted from the e-mails Marcos sent to me:

Status before the treatment, before May 28:
–  My wife’s tumors are found in the vertebra L2, bone and soft tissues around them.Size 6x4x5 cm.Lungs: about 14 very small nodules,the largest 1.2 cm, another 0.9, rest less than 0.4 cm
–  The tumor that gives problems is that of the vertebra L2 by its growth toward the spinal canal
In the analysis of tumor tissue (similar to foundation one)the mutations found were PI3K, PTEN, ESR1, and CTNNB1
– The state of my wife is very good, can travel, walking, cycling, does not appear to have this terrible disease, her capacity for fight and her desire to live are incredible. Despite the setting of 5 vertebrae in his back from the last operation.

Results reported on July 26:
–  The intensive treatment is giving a good result. reduction of tumor markers of 240 to 80. Destruction of half of the 14 lung nodules, with size reduction of the two largest. reduction in size of the lesion of the vertebra L2.

The treatment:
Part of the implemented treatment schedule was shared by Marcos here. The idea of his approach was to build an extensive treatment approach in order to increase the chance of success of the chemotherapy. This was done together with a medical doctor and they succeeded. Next to the chemotherapy, the treatment schedule included a few other substances expected to exert a strong pressure on the cancer cells, including glycolisis inhibitors such as 2DG intravenous and Salinomycin intravenous, but also diet approaches such as 3 days fasting before chemotherapy and Ketogenic Diet.
Marcos allowed me to publish his complete treatment schedule, but in order to mantain the safety of this website, if anyone is interested in knowing the details I think it’s best that you contact Marcos.

In my opinion the key of this success were the following aspects:

  • Attitude: Positive behavior, belief and expectation of Marco’s wife is essential
  • Coherent intravenous treatment: Correct type, dose and timing of additional intravenous treatments next to chemo
  • Coherent support for core treatments: Fasting before chemo, keto diet, and several other drugs and supplements used

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

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veeni
Member

Congrats to this awesome results….

[email protected]
Member

I second that! Congrats…. My dad is about to start a similar treatment.

– Jessica

Shanti
Member
Shanti

Marcos- I am very happy to hear of your success, may your battle continue to be successful. Daniel, thank you for providing the resources to make successes possible!

ovidiu
Member

I am impressed by the good stuff that Marcos was able to buy for his wife, but I have a couple of observations, just to clarify the targets of the treatment, and maybe a couple of suggestions:
– mutation PI3K means PI3K (part of the classic oncogenic pathway PI3K/AKT/mTOR) is aberrantly activated; the compounds listed there in theory can inhibit PI3K, even in synergetic combinations, but may not be enough, in comparison with a dedicated inhibitor; from my experience, Apigenin can worsen the blood formula, in my father’s case it didn’t help against the cancer; if you want to use Vit E, then use the Tocotrienol form, not the common Tocopherol, which may antagonize chemo;
– liposomal Tetrandrine is a very good choice, Tetrandrine (new to me) inhibits many oncogenic signals, including beta-catenin, which is linked to the CTNNB1 mutation; Itraconazole may also inhibit beta-catenin; but there may be a problem, by inhibiting beta-catenin, the osteoclasts are stimulated; while Tetrandrine seems to act against osteoclasts, you might want to consider adding Zoledronic acid, against the spinal metastasis, if it is deemed osteolytic; there are a couple of articles about the use of Zoledronic acid against metastases of endometrial cancer; BTW, it would be nice to know, for other readers of the site, where to buy liposomal Tetrandrine from, and how expensive it is;
– ESR1 is Estrogen receptor alpha, mutated means aberrantly activated, and Anastrazole should be inhibiting it;
– PTEN tumor suppressor, just above PI3K, mutated means silenced, Tetranderine may upregulate it if it’s not silenced; if silenced, it may not help much; there are possible treatments against PTEN null (silenced) cancers;
– the alternation of chemo and Salinomycin is a good choice, but I’m not sure about alternating 3BP and Salinomycin; maybe it would be worth trying simultaneous 3BP and Salinomycin, with lower doses; the reason is that Salinomycin is more cytotoxic under glucose starvation and hypoxia; I noticed that to counter the adverse effects from Salinomycin you use Amiodarone, I strongly suggest to switch to something else that would do the job; Amiodarone has a long half-life, and leads to the accumulation of several chemo agents, with potential lethal consequences;
– instead of Avastin (Bevacizumab) you might want to consider Nintedanib; in various cancer trials it proved superior to Bevacizumab;

marcosbomber901
Member

Hi Ovidiu.
Than you for your opinion,I very much appreciate your expert opinion.
The problem you see in the administration of 3BP and SALINOMYCIN, is to increase the oxygenation for 3BP to be effective, may decrease the effectiveness of salinomycin?. Such as separarias in the period of 21 days?.Normally it is said that 3BP would serve to make effective salinomycin.That is to say there is that prime salinomycin with chemotherapy or with 3BP.The protocol of Daniel on 3BP and Salinomycin is the one that i have done.
1.Nintedanib is not approved in Spain,your purchase in Sigma Aldrich is too expensive
2.I don’t have access to protease inhibitors PI3K/AKT/mTOR pathway.DoYou know of one cheap and effective?.
3Zoledronic acid. Don’t you think that its use could aggravate anemia which my wife presents almost constantly?.I’m scared of the osteonecrosis of the jaw. Could be used intermittently ,a month yes and a month no?.
4.Already taking anastrozole two years ago I did not mention it in the protocol.
5.Amiodarone will be deleted.
6.Tetrandrine purchased powder to 98% purity in naturemmfg.com and mixed with high quality Empty liposomes of Enoch Solution.
7.Please send me the studies of the use of zoledronic acid in endometrial cancer?.
Please any other suggestions or possible treatment let me know.Your help is critical

marcosbomber901
Member

Sorry for my English level if something does not understand I attempted to clarify

ovidiu
Member

@marcos: 3BP has a short half-life of only 77 minutes, so applying Salinomycin the next day might be too late to benefit from the synergy with 3BP;
The antitumor agent 3-bromopyruvate has a short half-life at physiological conditions. PMID: 25152397
With 3BP the problem is that, besides the short half life, by now (2+ months of treatment) the cancer may have downregulated MCT1…

1. Nintedanib might be approved for pulmonary fibrosis, but not for cancer, this may change, so keep an eye on it;
2. new synthetic inhibitors of PI3K/Akt/mTOR (not necessarily protease inhibitors like Nelfinavir or Ritonavir), tend to activate other survival pathways when used for some time; I still have to do more reading to understand the problem, so I can’t recommend one now; you are already using Metformin (sometimes only mTORC1 inhibitor, but in endometrial cancer full PI3K/Akt/mTOR inhibitor) and Tetrandrine for this purpose;
Metformin is associated with reduced cell proliferation in human endometrial cancer by inbibiting PI3K/AKT/mTOR signaling. PMID: 29182407
Involvement of PI3K/AKT/GSK3beta pathway in tetrandrine-induced G1 arrest and apoptosis. PMID: 18437054
You might want to replace Resveratrol with Pterostilbene, but you’ll have to import it from the USA, it’s scarce and more expensive in the EU;
Pterostilbene, a natural phenolic compound, synergizes the antineoplastic effects of megestrol acetate in endometrial cancer. PMID: 28986550
3. About ZOL, I don’t know, I suppose it might worsen anemia; you could check for low vitamin B12 levels, because of high dose Metformin, as a cause for anemia; osteonecrosis of the jaw is a more frequent for those with lots of teeth problems;
4. I saw Anastrazole listed by you, and is probably doing its job;
5. Pharmacokinetic interaction between taxanes and amiodarone leading to severe toxicity. PMID: 27868228
6. I tried searching with Google for naturemmfg.com and Enoch Solution Liposomes, but found nothing; so after some tweaking, came up with http://www.naturemfg.com/products/plant-extract/tetrandrine/ and http://www.enocpharma.com/?lang=en
7. An Unusual Solitary Metatarsal Metastasis from an Endometrioid Endometrial Adenocarcinoma. PMID: 26193447

Last, you might want to try Telmisartan, a cheap tumor stroma disrupting agent and a PI3K/Akt inhibitor, it synergizes with liposomal Docetaxel against a lung cancer Kras mutant in a mouse model. It may also synergize with the liposomal Tetrandrine, if Metformin hasn’t already disrupted tumoral stroma;
Tumor stromal disrupting agent enhances the anticancer efficacy of docetaxel loaded PEGylated liposomes in lung cancer. PMID: 27171485

marcosbomber901
Member

Hi Ovidiu.
I will try to apply salinomycin half an hour after 3BP,and to prevent the closure of the MCT1 line with paracetamol,EWOT etc.
Can i replace itracozanol by a statin as lovastatin that increases the expression of Pten.
In fact the two links to the pages of sale of tetrandrine and Empty liposomes are correct.
I can access easily pterostibeno.
Telmisartan will work just as well without the addition of doxorubicin?.
I do not think it is wise to apply together lovastatin and zoledronic acid,according to your experience which it would be more appropriate?.
I have access to celastrol known inhibitor of HSP90, we use together with Phlorizin to enhance the effects of hyperthermia that we are going to apply soon. What do you think?..
Thank you for your opinions

ovidiu
Member

@marcos: Daniel made his point, that 3BP can inhibit glycolysis for a longer time than suggested by the short half-life, and that’s why doctors use the alternate day regimen, so better keep the current schedule;
Telmisartan was suggested because the tumoral stroma could impede the delivery of many chemos, including the liposomes loaded with Tetrandrine;
About the simultaneous application of ZOL and a statin, I wish I had a sure answer… there are pros and cons…
A HSP90 inhibitor should be synergetic with hyperthermia, but the response to HSP90 inhibition is upregulation of HSP70;

Last, do you have a way to check that the stuff you bought is really what you paid for, and that it was stored and transported properly, so it is still >90% effective when used by the patient?

marcosbomber901
Member

Hi Ovidiu.
With regard to 3BP ,salinomycin and phlorizin i have total confidence were bought in SA. With regard to tetrandrine I bought at other times to this provider and accompanied by a certificate which includes storage temperatures that do not exceed 5 degrees.