A Drug Made for Animals and Taken by Humans to Treat Cancer: Fenbendazole

From anti-worms to anti-cancer

Previously, we discussed on this website the anti-worm drug Mebendazole (Ref.), which based on a good amount of scientific and clinical evidence, shows relevant anti cancer potential. Indeed, there are case reports published in peer review papers showing that Mebendazole can induce anti-cancer response in some aggressive cancers.

In the same article (Ref.) we explored the mechanism behind the anticancer action of Mebendazole, and found out that Mebendazole acts in a similar way as a group of chemotherapies such as Taxol. Yet, in contrast to chemotherapies, due to the way Mebendazole works, its toxicity is incomparably lower. Because of its good safety profile, the drug is an over the counter drug in most of the countries.

I specifically like the anti-worms, anti-parasites, antibiotics, antiviral drugs, as a pattern start to emerge suggesting that the origin of cancer may be related to such a trigger (e.g. viruses, parasites, etc.) in much more cases than we currently are aware of. Multiple findings and observations, that I will discuss in a different post, indicate that such triggers may initiate cancer when they land in a “fertile ground”, represented by specific genetic weaknesses combined with a compromised immune system (due to e.g. stress, lifestyle, medication, etc.). This is why, I would seriously consider using anti-worms, anti-parasites, antibiotics, antiviral drugs as a part of more comprehensive treatment approaches that could also include conventional therapies. As long as the toxicity is low, it could make sense to cycle various drugs of this type.

The anti-worm drug Fenbendazole has anti-cancer potential

In the same group of drugs as Mebendazole, a group called benzimidazoles, there is another anti-worm drug called Fenbendazole. Fenbendazole, is a drug used typically not for humans like Mebendazole, but for animals (including fish, birds and mammals). It is labelled to kill worms such as roundworms, hookworms, whipworms, and some tapeworms. Fenbendazole is found under various brand names such as Panacur or Safe-Guard.

I did came across this drug some years ago during my research, but only recently I was motivated to look closely at it following several e-mails from friends who shared with me the blog of a man with Small Cell Lung Cancer, who successfully treated his cancer with Fenbendazole (Ref.). On his website,  Joe Tippens, not only reports his experience but also anecdotally reports being in contact with more patients experiencing benefits while using Fenbendazole, including two cases of 4th stage Pancreatic Cancer, Prostrate Cancer, Colorectal Cancer, Non-Small Cell Lung Cancer, Melanoma, Colon Cancer.  This anecdotal report would not be enough to trigger me writing this post, if I would not be convinced by the existing scientific evidence indicating the anti cancer potential connected with many of the benzimidazoles drugs. Therefore, I do believe that if Mebendazole could show relevant anti-cancer effects in humans, which it did, Fenbendazole could do it as well and hopefully even better.

In some diseases, it has been indeed shown that Fenbendazole can be more effective than Mebendazole. For example, when tested against Cryptococcus neoformans (an encapsulated fungal organism that can cause disease such as meningoencephalitis in immunocompromised hosts), it has been shown that Fenbendazole was more active than Mebendazole or other drugs against this opportunistic fungus (Ref.).

While there is more prior literature suggesting anti cancer effectiveness related to Fenbendazole, the paper I found most relevant to specifically cite here first is a paper that was just published during 2018 in one of the most prestigious scientific magazine, that is Nature, which adds a lot of weight to the communicated message. This paper, entitled “Fenbendazole acts as a moderate microtubule destabilizing agent and causes cancer cell death by modulating multiple cellular pathways“, concludes the following:

  • “The results, in conjunction with our earlier data, suggest that Fenbendazole is a new microtubule interfering agent that displays anti-neoplastic activity and may be evaluated as a potential therapeutic agent because of its effect on multiple cellular pathways leading to effective elimination of cancer cells.”

In this paper, the authors cite potential anti cancer mechanisms associated with Fenbendazole, including disruption of microtubule function and proteasomal interference, but it was also associated with blocking the glucose uptake by cancer cells (through reducing the expression of Glut-4 transporter as well as hexokinase) and thus starving cancer cells. This means Fenbendazole could also work nicely in supporting chemotherapy and radiotherapy as well as metabolic therapies. Because of the way it works (interacting with a site on tubulin similar to colchicine but distinct from that of Vinca alkaloids), Fenbendazole will not compete with Vinca alkaloids (such as Taxol) but instead will add to the anti cancer effect of these conventional treatments similar to other benzimidazoles (Ref.).

Interestingly, when insulin stimulates glucose uptake in the cells, glucose transporter isoform 4 (GLUT4) translocates from intracellular vesicles to the plasma membrane ready to absorb glucose. This movement of GLUT4 towards the plasma membrane takes place via both rapid vibrations around a point and short linear movements (generally less than 10 microm). The linear movement seems to take place along microtubules. When disrupting the microtubules with drugs such as Fenbendazole, GLUT4 movements are disrupted as well strongly reducing insulin-stimulated glucose uptake (Ref.).

Another very interesting point coming from the Nature paper cited above is that Fenbendazole shows strong synergy when combined to DCA, a drug that I discussed earlier on this website https://www.cancertreatmentsresearch.com/dichloroacetate-dca-treatment-strategy/ So it may make very much sense to combine the two, and possibly 2DG (Ref.). Could it be that the origin of this synergy comes from the possible glutathione depletion previously observed to be related to Fenbendazole? (Ref.)

While Fenbendazole could be relevant for many types of cancers (as also suggested by the anecdotal reports listed above and by literature on the anticancer effects of benzimidazoles drugs) prior literature has so far indicated it’s anti cancer effects in

  • Non-small Cell Lung Cancer Cells (NSCLC) (Ref.)
    • Fenbendazole inhibits the cellular proteasome function dose- and time-dependently and leads to accumulation of ubiquitylated derivatives of various cellular proteins, including p53, which, in turn, leads to apoptosis via the mitochondrial pathway
    • the cells first undergo G2/M arrest followed by apoptosis
    • Fenbendazole induced endoplasmic reticulum stress, reactive oxygen species production, decreased mitochondrial membrane potential, and cytochrome c release that eventually led to cancer cell death.
  • Lymphoma (Ref.)
  • Prostate Cancer (Ref.) and  taxane-resistant prostate cancer cells (Ref.)
  • Glioblastoma (Ref.1, Ref.2)

The questions, is why I would consider using Fenbendazole, a drug used for animals, when we already have Mebendazole made for use in humans that is associated to similar anticancer mechanisms? There are three major reasons for me to do that and consider trying Fenbendazole as well:

  • First, as discussed above, in some diseases, Fenbendazole was more effective than Mebendazole;
  • Second, it is known that this type of drugs is not very well absorbed in the body and the absorption may differ from person to person (Ref.). Therefore switching between different drugs with similar expected mechanisms may make sense as one of them may be better absorbed in our specific case;
  • Third, there is a good chance that the underlying anti-cancer mechanism is different for each of the drugs, even if the scientific observations suggest similar mechanisms of action (we should always remember that science represents not a complete understanding of nature, but only steps towards a better understanding).

Update September 2019: at the beginning of 2019, some months after I wrote this post, Joe’s story became viral. Here is a short interview on a TV station in US, with Joe https://www.youtube.com/watch?v=HYILnjc_wuY I am glad to see that I often addressed subjects on this website before they became known to most people.

Fenbendazole is well tolerated in humans

Although a drug that is used for animals, according to a report available at the European Medicine Agency “Fenbendazole seems to be well tolerated in humans after oral exposure (single oral dose up to 2,000 mg/per person; 500 mg/per person for 10 consecutive days)” (Ref.)

What type and how is Fenbendazole used

Taking Panacur C granules from Merck

There are people taking it for deworming and they seem to prefer the Fenbendazole version that is meant to be used for fish (Ref.). In this case, its is used in the range of 5mg/kg/day to 10mg/kg/day.

However, on his website,  Joe Tippens, shows a picture of Panacur C box from Merck, sold as Canine Dewormer, containing Fenbendazole granules 22.2%. This means every gram of granules contains 222mg of pure Fenbendazole.

Dose and treatment regime

Below I discuss the dose and treatment regime but this is only visible to registered visitors. All visitors can easily register, for free, using the login options located at the right side of the page (when using a desktop) or at the bottom of the page (when using mobile), where login option via Facebook account is also available. It only takes one minute to registered on this website, while it may take much longer to collect the information addressed here.

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However, just to stay on the safe side, because of its anti oxidant properties I would not use Vit E during the chemo or radio therapy.

Where to buy

Panacure C can be found all over the world at online shops. It can be found in packages of 3 packets of 1g granules (or 222mg Fenbendazole, for small dogs) or 3 packets of 2g granules (or 444mg Fenbendazole, for adult dogs).

Fenbendazole should not be confused with Flubendazole.

Final Note

Update December 2019: Dear reader, many visitors of this website in search for information on Fenbendazole are reading this article and after that they live this website. However, they live behind important value. Continue reading this website and you will find other treatments that may have same or better effectiveness compared to Fenbendazole but people are not aware of them just because very few of such news made it to the news, as the story of Joe Tippers did.

For example, see here a case report recently published in scientific literature https://www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/, of a man who had stage IV cancer with many sites’s of metastasis including liver and lungs. He was not responding to conventional treatments and he was sent home to die. He treated himself at home with an unconventional treatment approach and three months after that his medical doctors report that he obtained complete remission. And here is another recent (2018) example: (Ref) the case of a medical doctor from US with stage 4 pancreatic cancer,  who next to his conventional treatment added two repurposed drugs. With that he obtained complete remission.  My point is: when you find time, explore this website. I share everything for free with you. All my search for new treatment options with potential is meant to help you with more treatment ideas and all are science based.

References

In vitro anti-tubulin effects of mebendazole and fenbendazole on canine glioma cells. https://www.ncbi.nlm.nih.gov/pubmed/28078780

Benzimidazole anthelmintics have reported anti-neoplastic effects both in vitro and in vivo. The purpose of this study was to evaluate the in vitro chemosensitivity of three canine glioma cell lines to mebendazole and fenbendazole. The mean inhibitory concentration (IC50 ) (±SD) obtained from performing the MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] assay after treating J3T, G06-A, and SDT-3G cells for 72 h with mebendazole were 0.030 ± 0.003, 0.080 ± 0.015 and 0.030 ± 0.006 μM respectively, while those for fenbendazole were 0.550  ± 0.015, 1.530 ± 0.159 and 0.690 ± 0.095 μM; treatment of primary canine fibroblasts for 72 h at IC50 showed no significant effect. Immunofluorescence studies showed disruption of tubulin after treatment. Mebendazole and fenbendazole are cytotoxic in canine glioma cell lines in vitro and may be good candidates for treatment of canine gliomas. Further in vivo studies are required.

Impairment of the Ubiquitin-Proteasome Pathway by Methyl N-(6-Phenylsulfanyl-1H-benzimidazol-2-yl)carbamate Leads to a Potent Cytotoxic Effect in Tumor Cells https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3436308/

In recent years, there has been a great deal of interest in proteasome inhibitors as a novel class of anticancer drugs. We report that fenbendazole (FZ) (methyl N-(6-phenylsulfanyl-1H-benzimidazol-2-yl)carbamate) exhibits a potent growth-inhibitory activity against cancer cell lines but not normal cells. We show here, using fluorogenic substrates, that FZ treatment leads to the inhibition of proteasomal activity in the cells. Succinyl-Leu-Leu-Val-Tyr-methylcoumarinamide (MCA), benzyloxycarbonyl-Leu-Leu-Glu-7-amido-4-MCA, and t-butoxycarbonyl-Gln-Ala-Arg-7-amido-4-MCA fluorescent derivatives were used to assess chymotrypsin-like, post-glutamyl peptidyl-hydrolyzing, and trypsin-like protease activities, respectively. Non-small cell lung cancer cells transiently transfected with an expression plasmid encoding pd1EGFP and treated with FZ showed an accumulation of the green fluorescent protein in the cells due to an increase in its half-life. A number of apoptosis regulatory proteins that are normally degraded by the ubiquitin-proteasome pathway like cyclins, p53, and IκBα were found to be accumulated in FZ-treated cells. In addition, FZ induced distinct ER stress-associated genes like GRP78, GADD153, ATF3, IRE1α, and NOXA in these cells. Thus, treatment of human NSCLC cells with fenbendazole induced endoplasmic reticulum stress, reactive oxygen species production, decreased mitochondrial membrane potential, and cytochrome c release that eventually led to cancer cell death. This is the first report to demonstrate the inhibition of proteasome function and induction of endoplasmic reticulum stress/reactive oxygen species-dependent apoptosis in human lung cancer cell lines by fenbendazole, which may represent a new class of anticancer agents showing selective toxicity against cancer cells.

Unexpected antitumorigenic effect of fenbendazole when combined with supplementary vitamins. https://www.ncbi.nlm.nih.gov/pubmed/19049251

Diet containing the anthelminthic fenbendazole is used often to treat rodent pinworm infections because it is easy to use and has few reported adverse effects on research. However, during fenbendazole treatment at our institution, an established human lymphoma xenograft model in C.B-17/Icr-prkdcscid/Crl (SCID) mice failed to grow. Further investigation revealed that the fenbendazole had been incorporated into a sterilizable diet supplemented with additional vitamins to compensate for loss during autoclaving, but the diet had not been autoclaved. To assess the role of fenbendazole and supplementary vitamins on tumor suppression, 20 vendor-supplied 4-wk-old SCID mice were assigned to 4 treatment groups: standard diet, diet plus fenbendazole, diet plus vitamins, and diet plus both vitamins and fenbendazole. Diet treatment was initiated 2 wk before subcutaneous flank implantation with 3 x 107 lymphoma cells. Tumor size was measured by caliper at 4-d intervals until the largest tumors reached a calculated volume of 1500 mm3. Neither diet supplemented with vitamins alone nor fenbendazole alone caused altered tumor growth as compared with that of controls. However, the group supplemented with both vitamins and fenbendazoleexhibited significant inhibition of tumor growth. The mechanism for this synergy is unknown and deserves further investigation. Fenbendazoleshould be used with caution during tumor studies because it may interact with other treatments and confound research results.

Effects of fenbendazole and vitamin E succinate on the growth and survival of prostate cancer cells 

We describe antitumor activities of vitamin E succinate (VES), an anti-oxidant and fenbendazole (FBZ), a commonly used veterinary anthelmintic. We used VES and FBZ, at low concentrations, singly and in combination, to test their inhibitory effects on proliferation of human and mouse prostate cancer cells in vitro. Administered alone, FBZ inhibited proliferation faster than VES in both mouse and human prostate cancer cell lines and a synergistic effect between both was also observed. Apoptosis was the likely mechanism for the observed effect. These drugs may deserve to be tested for their efficacy in the control of prostate cancer using in vivo models.

Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme. https://www.ncbi.nlm.nih.gov/pubmed/21764822

Glioblastoma multiforme (GBM) is the most common and aggressive brain cancer, and despite treatment advances, patient prognosis remains poor. During routine animal studies, we serendipitously observed that fenbendazole, a benzimidazole antihelminthic used to treat pinworm infection, inhibited brain tumor engraftment. Subsequent in vitro and in vivo experiments with benzimidazoles identified mebendazole as the more promising drug for GBM therapy. In GBM cell lines, mebendazole displayed cytotoxicity, with half-maximal inhibitory concentrations ranging from 0.1 to 0.3 µM. Mebendazole disrupted microtubule formation in GBM cells, and in vitro activity was correlated with reduced tubulin polymerization. Subsequently, we showed that mebendazole significantly extended mean survival up to 63% in syngeneic and xenograft orthotopic mouse glioma models. Mebendazole has been approved by the US Food and Drug Administration for parasitic infections, has a long track-record of safe human use, and was effective in our animal models with doses documented as safe in humans. Our findings indicate that mebendazole is a possible novel anti-brain tumor therapeutic that could be further tested in clinical trials.

Identification of selective therapeutic agents for metastatic prostate cancer by phenotype-based screening http://www.dtic.mil/dtic/tr/fulltext/u2/a545657.pdf

Background: As with many solid tumors, the prognosis for prostate cancer patients worsens when tumors metastasize to distant organs, such as the bone. Current chemotherapy is relatively limited for metastatic prostate cancer. Methods: We utilized a screening method consisting of multiple panels of highly metastatic and less metastatic prostate cancer cells to identify compounds that selectively target metastatic prostate cancer cells but not on less metastatic and normal prostate epithelial cells. Selected drugs from a library of 1120 FDA-approved drugs were then tested for their ability to improve the survival of mice in a highly aggressive Dunning rat prostate carcinoma lung metastasis model, and for anti-tumor activity on paclitaxel-resistant and experimental bone lesion of prostate tumors. To improve the bioavailability of agents for systemic administration, we
utilized a modified micelle preparation as well as nanoparticle (PLGA-PEG)-based formulation. Results: We identified fenbendazole, fluspirilene, clofazimine, niclosamide and suloctidil, which showed selective cytotoxicity on metastatic prostate cancer cells in vitro and in vivo. Such selectivity could explained by differential induction of apoptosis. Upon improvement in bioavailability, fenbendazole and albendazole significantly extended the survival of metastases bearing mice, and the extension of lifespan by albendazole was equivalent or greater than that provided by paclitaxel. These drugs were active in taxane-resistant tumors and in the bone microenvironment, two clinical conditions of men with advanced prostate cancer. Conclusion: Metastatic tumor cells differ in their responses to certain drug classes. Albendazole shows promise as a potential adjunct to standard therapy in patients with metastatic prostate cancer.

An Overview of Tubulin Inhibitors That Interact with the Colchicine Binding Site https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3667160/

Tubulin dynamics is a promising target for new chemotherapeutic agents. The colchicine binding site is one of the most important pockets for potential tubulin polymerization destabilizers. Colchicine binding site inhibitors (CBSI) exert their biological effects by inhibiting tubulin assembly and suppressing microtubule formation. A large number of molecules interacting with the colchicine binding site have been designed and synthesized with significant structural diversity. CBSIs have been modified as to chemical structure as well as pharmacokinetic properties, and tested in order to find a highly potent, low toxicity agent for treatment of cancers. CBSIs are believed to act by a common mechanism via binding to the colchicine site on tubulin. The present review is a synopsis of compounds that have been reported in the past decade that have provided an increase in our understanding of the actions of CBSIs.

Exacerbation of Acetaminophen Hepatotoxicity by the Anthelmentic Drug Fenbendazole (Ref.)

Fenbendazole is a broad-spectrum anthelmintic drug widely used to prevent or treat nematode infections in laboratory rodent colonies. Potential interactions between fenbendazole and hepatotoxicants such as acetaminophen are unknown, and this was investigated in this study. Mice were fed a control diet or a diet containing fenbendazole (8-12 mg/kg/day) for 7 days prior to treatment with acetaminophen (300 mg/kg) or phosphate buffered saline. In mice fed a control diet, acetaminophen administration resulted in centrilobular hepatic necrosis and increases in serum transaminases, which were evident within 12 h. Acetaminophen-induced hepatotoxicity was markedly increased in mice fed the fenbendazole-containing diet, as measured histologically and by significant increases in serum transaminase levels. Moreover, in mice fed the fenbendazole-containing diet, but not the control diet, 63% mortality was observed within 24 h of acetaminophen administration. Fenbendazole by itself had no effect on liver histology or serum transaminases. To determine if exaggerated hepatotoxicity was due to alterations in acetaminophen metabolism, we analyzed sera for the presence of free acetaminophen and acetaminophen-glucuronide. We found that there were no differences in acetaminophen turnover. We also measured cytochrome P450 (cyp) 2e1, cyp3a, and cyp1a2 activity. Whereas fenbendazole had no effect on the activity of cyp2e1 or cyp3a, cyp1a2 was suppressed. A prolonged suppression of hepatic glutathione (GSH) was also observed in acetaminophen-treated mice fed the fenbendazole-containing diet when compared with the control diet. These data demonstrate that fenbendazole exacerbates the hepatotoxicity of acetaminophen, an effect that is related to persistent GSH depletion. These findings are novel and suggest a potential drug-drug interaction that should be considered in experimental protocols evaluating mechanisms of hepatotoxicity in rodent colonies treated with fenbendazole.

Update August 24th, 2019: several months after I wrote this article, the story of Joe Tippens made the news, and after that it went viral. Following that, some Facebook groups have been created where people are discussing the use of Fenbendazole against cancer. Here is one such group https://www.facebook.com/groups/429159131252194/  (Fenbendazole for Cancer Group)

Disclaimer

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

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319 thoughts on “A Drug Made for Animals and Taken by Humans to Treat Cancer: Fenbendazole

    1. Since no one knows which one would be better, I would try both as toxicity is low.
      I would probably combine 1g granusles Fenbendazole/day (that is 222mg/day active component) 3days ON and 4 days OFF, and 200mg/day Mebendazole also 3 days ON and 4 days OFF. I would take them together during the same days. Also, I would take them with some oils, like Omega 3, for a better absorption.

      Kind regards,
      Daniel

      1. Hi Daniel

        Great and very detailed article.

        I have been diagnosed with prostrate cancer. I am based in N’Djamena, Chad. I tried to buy Fenbendazole online and it seems I require a prescription from. Veterinarian to complete the transaction. I am in New York for two weeks and would like to buy and to take it with me back. Anyway that you can assist?

            1. I managed to get Panacr c from countrysidepetsuppl web site and no prescription needed. Cost was US$ 29.93 for 3 packs by 200 grms.

        1. I’m in Ohio. I can purchase from my local farm store, in my case Tractor Supply. You can purchase from Chewy.com (pet products) online. No prescription is required from either of these companies.

        2. Daniel,

          I hope you were able to buy Fenbendazole by now, but if not go to Chewy.com and order Safe-Guard brand of Fenbendazole. It’s the same as Panacure C and without a prescription and a lot cheaper. It’s less than $5.00 U.S. dollars for a week supply. They can ship to you anywhere.

      2. Hello Daniel:
        There are three different dosages of Panacur C for sale.
        To be clear, are you recommending a one gram packet for days 1-3 and
        then days 4-7 off. The one gram packets contain 222mg of FB and are recommended
        to treat worms in a 10 pound dog. There are also 2 gram and 4 gram packets available.

        FB does not dissolve well in water so I purchased a capsule making jig and empty capsules.
        Thanks
        JJ

        1. HI JJ,

          Indeed, there are different dosages available and in different composition. According to Joe who is our main reference point in terms of effective dose, he used one gram packets containing 222mg of FB, each days 3 days ON and 4 OFF. So you understood correctly. If someone has access to only 2g or 4g packets and wants to use that, he/she needs to check how much active ingredient is inside each gram and divide the granules inside the packs so that 222mg active ingredient is taken/day. This should be very easy.
          I never had my hands on the granules to see how difficult is to dissolve in water. However, I think I would try to dissolve them in water as much as possible before drinking instead of taking them inside capsules. It should be better for it’s absorption in the body. Adding some fatty food should further help it’s absorption.

          Kind regards,
          Daniel

          1. I have neuroendocrine cancer that started in the cardia of my stomach, that spread to my liver. Going thru chemo and immunotherapy now. Any info on the dog dewormer for this type of cancer. By the way I couldn’t find area to just place an original comment.

            1. Hi,

              1. Regarding chemo for neuroendocrine tumors this info may be relevant:

              “Unprecedented Responses Seen in Neuroendocrine Tumors https://www.medscape.com/viewarticle/819220

              Comment from Dr. anastasios salesiotis, oncologist, to the above article: “why are you surprised? you need to simply consider the folowing. i have had four patients with such tumors alive four years post-inititation of captem. th biopsies stained via IHC (very positive for MGMT-the proven target for temozolamide and very positive for high ratio of TP/DPD the final activating -TP- and the degradiing enzyme for capecitabine). this is not rocket science. this simple aplplication of known facts in glioblastoma and colon ca and reapplication of these facts in neuroendocrine tumors. well done Dr Fine!!!!”

              Aggressive Grade 2 Neuroendocrine Tumor Salvaged by Temozolomide- Based Therapy: A Case Report and Literature Review https://www.omicsonline.org/open-access/aggressive-grade-2-neuroendocrine-tumor-salvaged-by-temozolomidebased-therapy-a-case-report-and-literature-review-2471-8556-1000147-104561.html

              If you have a medical doctor to help implement this treatment https://www.cancertreatmentsresearch.com/a-new-approach-to-improve-effectiveness-of-cancer-therapies-is-getting-ready-to-begin-human-trials/ please let me know and I can put your medical doctor in contact with the academic team who can support him with the required info. This could help increase the chance for effectiveness of chemo.

              2. For immunothrepahy you may want to read this https://www.cancertreatmentsresearch.com/gut-bacteria-amplifies-immunotherapy/ and this https://www.cancertreatmentsresearch.com/dendritic-cell-therapy-supporting-strategies/ but the most important when doing immunotheraphy is lowering the pH around the tumors so that the immune system can work. Here is a complete strategy addressing pH https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/

              This is also relevant: Targeting tumor-associated acidity in cancer immunotherapy https://link.springer.com/article/10.1007/s00262-018-2195-z

              3. Please read this comment as part of it could be relevant to any tumor type: https://www.cancertreatmentsresearch.com/fenbendazole/#comment-8822

              4. I think you already found that you can place new comments on the Forum, here https://www.cancertreatmentsresearch.com/community/

              Kind regards,
              Daniel

      3. Hi how are you.
        I e just been diagnosed with pancreas and liver cancer. This all happened fast so I’m new to all this.
        I do like the artical of joe Tippens. Can you inform me more please.

        Is this at clinic trials anywhere etc
        Just any info I would be so happy to receive from you
        Thx
        Chris

        1. chris, sorry for the news.
          Yes, I totally understand; there is so much research out there and it feels completely overwhelming.
          We are here to help!

          Over the last few years we have seen posters on thread that have done better than expected.
          The basic ideas that we have found helpful are using metabolic medicine with metronomic dosing, doing
          this with a glycolysis and an OXPHOS blocker can severely deplete cancer cell energy etc. .

          The advice on this forum and elsewhere that embraces a metabolic approach appears to enhance treatment effectiveness.
          For example, we have noted that a clinic in Turkey posted a patient series of pancreatic patients that achieved
          better results with their so-called metabolically supported chemotherapy.

          A poster on this forum, Jess, whose father is coping with pancreatic cancer, did a variant of this treatment and also appeared to benefit. In the biomarker charts, adding in metronomic metabolic treatment clearly appeared to turbo charge the effectiveness of the chemo. Perhaps you could try a similar strategy and then amp it up with some of the new treatments that we have found more recently, such as FB, silver, etc. Often times it not clear exactly how to move forward, though posters have seemed able to navigate these uncertainties quite well.

          It might be a good place to start if you were to click on the Visitor Story tab at the top of the page and click on Jess. The Turkish clinic’s metabolic lung cancer patient series was even more impressive. Educating yourself about a calorie restricted ketogenic diet would probably be a good idea.

          https://chemothermia.com/

          We continue to learn new approaches, so FB and others might also be of interest to you.
          There are actually quite a number of potentials that you will find mentioned here.
          One general piece of advice that I would give you is to try not to become so intimidated by it all that
          you don’t actually get around to trying many of the ideas.

          The problem is that many of the ideas that are presented on this forum typically do not have clinical trials.
          FB is a dog dewormer and can be purchased online for about $15.
          It is unlikely that many of these ideas will ever see a clinical trial.
          The people on forum are willing to go off-road when they feel there is no other obvious choice.

          There are a fair number of treatments online that have been used for up to thousands of years and
          are generally regarded as safe even by the American EPA (e.g. silver nanoparticles). Many people
          would wind up endlessly thinking about even treatments that are as relatively safe as silver while
          consuming precious time that they could be using to investigate many others. Usually when people
          talk about the toxicity of metabolic approaches such as silver, methylglyoxal, 3-BP, etc etc. it almost
          always at dosage levels that are excessive. With silver, overdosing can turn your skin permanently
          grey though this only occurs at extremely high doses.

          D, is traveling and will be outside of communication range for a while (possibly a week). He might
          be able to offer you some of the insights that he has gained over the last number of years.

          It is my best understanding that the approaches suggested on forum that have been used by patients
          similar to you have resulted in benefit to these patients.

          Sending out my best wishes to you in a difficult time, Jcancom

        2. Hi Chris,
          J gave you a great overview of some of the great info on this site. I know there is a lot of it, but you can start to implement something right away as you learn and develop an approach. So you could start, for example with Fenbendazole and other supplements as described by Joe Tippens (Vitamin E, Curcumin, CBD): https://www.mycancerstory.rocks/single-post/2016/08/22/Shake-up-your-life-how-to-change-your-own-perspective. To that you could add HCA and alpha lipoic acid as written about by Daniel here: https://www.cancertreatmentsresearch.com/another-weak-spot-of-many-cancer-cells-atp-citrate-lyase-inhibition/ and silver from a recent post: https://www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/. These are all items that are easy to find an implement while you consider other approaches. Things to consider are if you have access to IV therapy or doctors who are able to help you out with “off road” approaches. It is always good to check any medication you want to implement for interactions with an online checker, like this one: https://www.drugs.com/drug_interactions.html. As Daniel has pointed out, it is also best to start therapies at a lower dose and work up.

        3. Johan has a useful post on natural supplements: https://www.cancertreatmentsresearch.com/fenbendazole/#comment-8470 and, depending on the state of your cancer, your weight and if you are cachexic, you might want to consider a dietary approach using caloric restriction and juicing green drinks. Dr. George Yu provides some statistics here on how well a dietary approach like this might work: https://yufoundation.org/about-us. It could also give you more time to put together a comprehensive approach. Wishing you the very best.

        4. Hi Chris,

          In addition to the great information from J and Shanti, here’s an interesting study on Tamoxifen for pancreatic and liver cancers:

          “In a new study, the team of researchers could demonstrate on mice that Tamoxifen also weakens the physical environment of solid tumours, such as pancreatic cancers and some forms of liver cancer. “Tamoxifen helps to change the physical environment in which tumours grow”
          https://erc.europa.eu/projects-figures/stories/new-weapon-against-pancreatic-cancer-way

          Tamoxifen is a very well known drug and has a good safety profile. My father-in-law has been taking it for 16 years now!

          Another drug that you might want to propose to your oncologist is sodium phenylbutyrate. “It has been observed that phenylbutyrate induces up to 70% apoptosis in pancreatic carcinoma cell lines Panc 1, T4M-4, COLO 357, and BxPc3.”

          Both drugs also appear to do well if taken together.

          Best Regards,
          Johan

          1. Chris, if it is within your budget a trip to Arizona would make a great deal of sense.
            (roughly $25,000 – $30,000) Dayspring utilizes an alternative treatment approach with 3-BP
            at the center. After years of treatment experience with 3-BP, it is their opinion that properly
            formulated 3-BP is possibly the most powerful available anti-cancer integrative therapy.
            They have a range of other approaches that amplify the basic treatment.

            http://dayspringcancerclinic.com/

            Letting those with expertise provide the treatment would greatly reduce the confusion and
            stress from trying to reverse engineer a solution. All you would need to do is show up and let
            them do the rest! After many years, we have found that somewhat small modifications (such
            as metronomic dosing) can make large changes in outcomes. There are likely a range of other
            tricks that we have still not found, though those with greater knowledge have.

            Best Wishes, J

        5. it seems the toxicity in this is low enough not to have major side effects. I would try it. just follow what Tippens did. What have you got to lose? good luck (if you wait around for more studies you could be dead. just do it. it wont kill you but you know what can)

        6. Chris,

          The way Panacure C (Fenbendazole) works is by starving the cancer cells. It blocks the carbohydrates from cancer cells, but not from healthy cells. Cancer needs carbohydrates to survive. I would think that since it starves cancer cells, it would work for any type of cancer. Just my logic. Be blessed.

          Tip: Order Fenbendazole from Chewy.Com. The Safe-Guard brand is exactly the same as Panacure C, but about 1/2 the price. A week supply is less than $5.00 US.

  1. A great article, well detailed, as always. Thank you!
    We use mebendazol since about 1,5 years and still have some stock, but as soon as it is sold out we will try Fenbendazol. In addition it is easier to find, without prescription and cheaper !
    I was wondering already for mebendazole, but do you think can we combine them with pyrvinium, Daniel (both being anthelmintic)?

    1. Thanks for reporting Shane. Both Mebendazole and Cimetidine are drugs I like based on their anti cancer activity. I wrote about Mebendazole here https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/ As I remember, first time in my life I read about Mebendazole was on the abovetopsecret website in 2014 and it may just be your post. So, thank you very much again. Are you still taking the two?

      1. Hello Dan .. I’ve not taken them for 3 -4 years and have had regular check ups and still all clear .. just let you know I told my specialist from Christie’s hospital 4 years ago about what I’d taken and he’d never heard of them but now they are using both drugs in trails in Christie’s in conjunction with chemo at the moment so it’s looking like it’s getting the attention the drug deserves ..I’ve also helped a couple of people in my home town with them an both have had the all clear ..

        1. HI Shane, thank you. As I understand you had Ostersarcoma with mets to the lungs. The treatment you used was 100mg Mebendazole tablets 3 times a day, 200 mg cimetidine tablets 4 times a day and 50 grams of Glutamine power twice a day. Can you please let me know what was the cancer type of those who may have benefited from Mebendazole, and the dose they used? Also, could you please share the link to the trial on chemo+mebendazole at Christie’s? Thank you.

  2. Hello! I was just introduced to the blog by Joe last week and by no coincidence came upon your report, which I references this same Joe. I am hopeful in both of your writings. My husband was diagnosed with renal cell carcinoma in 2017, and is a patient at MD Anderson. Would Fenbendazole &Vitamin E be beneficial to someone with renal cell carcinoma? I understand your disclaimer, but can you please tell me in your best opinion if you think this could be beneficial to him. I appreciate your time and any comments you can offer. Thank you!

    1. Hi,

      the toxicity of drugs like Fenbendazole is relatively low. So I think for most patients it makes sense to try it for some time and see if there is added value. Of course I would use Fenbendazole just as an addition to other treatments, such as those provided by MD Anderson, to increase chance of positive outcome. Beyond Fenbendazole, you may like to read through this website and the forum https://www.cancertreatmentsresearch.com/community/ for other relevant options such as this one https://www.cancertreatmentsresearch.com/community/kidney-cancer/the-long-term-survival-of-a-patient-with-stage-iv-renal-cell-carcinoma-following-an-integrative-treatment-approach-including-the-intravenous-α-lipoic-acid-low-dose-naltrexone-protocol/
      On both the main web-page and the forum page there are search options where you can search for keywords such as “renal” or “kidney”.

      Kind regards,
      Daniel

  3. Hi Daniel,

    If we were to combine Joe’s protocol for fenbendazole with your suggestion for mebendazole then the supplements would be vitamin E, curcumin, CBD oil, cimetidine, and Omega 3. Do you have any concerns about this combination causing adverse effects, e.g. upset stomach?

    We are also considering adding another dewormer, niclosamide, based on this article:
    https://www.ucsf.edu/news/2017/03/406321/deworming-pill-may-be-effective-treating-liver-cancer

    The article mentions that the salt form of niclosamide (niclosamide ethanolamine) is more soluble and hence may overcome the absorption problem that necessitates some of the supplements. Our hesitation about this salt form is that we cannot find any dosing information. Do you have any thoughts about this?

    Thanks much,
    Pat

    1. Dear Pat,

      Now I see your comment. I realize this may not be relevant anymore, but here is my answer:

      I have no concerns about the comboo you mentioned other than the fact that Cimetidine may interact with other medication. So whenever you start using new medication on top of Cim, add that step by step, and before that read the possible interactions. Some drugs will not be metabolised by the liver leading to – high plasma level of some drugs or for others (such as hormonal treatments) non-effectiveness as they are not metabolised in the active compound.

      I discussed in another place on this website (please use the search function) that Niclosamide absorption will be increased when taken with alcohol

      Kind regards,
      Daniel

  4. D, did you notice the combination index of Fenbendazole and DCA from the Nature 2018 article?
    0.04? Is that even possible? There is massive massive synergy between them.
    Why has this not been more highlighted in the discussion?

    It should be of no great surprise when combining 2 anti-glycolytics that this should happen though this
    is even more extreme than I would have expected. There was also synergy with 2-DG.

    I would be interested to see if they publish formulations for FB.
    nanoFB (i.e. with chitosan perhaps)?

    https://www.nature.com/articles/s41598-018-30158-6

    1. J, sorry for only now checking your point. Thanks a lot for the heads up. Indeed it seems that Fenbendazole and DCA show strong synergy in these experiments. I will add a note on this on the DCA page too.

      Btw, you may want to have a look at this Nature paper. It’s very interesting https://www.cancertreatmentsresearch.com/community/breast-cancer/repurposed-drug-combination-of-two-fda-approved-drugs-shows-potential-in-triple-negative-breast-cancer/#post-1037

      1. Also Fen and 2-DG.

        I have been unsure for quite some time about what would be the best anti-glycolytics to finish out the combo with
        OXPHOS inhibitors. However, now there appears to be quite a few. The silver nanoparticle article below offers another choice. We are reaching a point now in which we have a whole bunch of these that could be taken off the shelf and potentially have
        very large anti-cancer effects. Turning off OXPHOS and glycolysis at the same time almost ensures such an outcome.

        https://www.dovepress.com/silver-nanoparticles-induce-reactive-oxygen-species-mediated-cell-cycl-peer-reviewed-article-IJN
        https://www.ncbi.nlm.nih.gov/pubmed/28521959

  5. Yes, there are likely quite a few of our old favorites that should synergize nicely with FB. It is always frustrating when we find a new path forward and the research lags behind. I was quite impressed though how strong the DCA synergy was with FB.

  6. Hi, Daniel. I am planning to try the combination of Fenbendazole and Mebendazole for my mum. But, I can’t find Panacur C at my country. Instead, I can easily find an alternative named “Quantel” in form of tablet at my place. It states containing Praziquantel PhEur 50mg and Fenbendazole PhEur 500mg.

    My question is that do you think Quantel is a suitable alternative to Panacur C in the sense that both have fenbendazole as the primary gradient? Or, it is better to use Panacur C?

    1. Dear Fung. If it contains Fenbendazole that is what you are looking for. Praziquantel is one that I like too. It is an anthelmintic used in both human and veterinary medicine. It has anticancer effects too and it was shown that Praziquantel could greatly enhance the anticancer efficacy of Taxol in various cell lines including Taxol resistant cell lines. So I see no reason why not use Quantel. Just make sure you use the normal dose. 50mg/day Praziquantel seems to be in the low dose range but please investigate yourself https://reference.medscape.com/drug/biltricide-praziquantel-342666

    1. Hi,
      good question. Bone marrow aplasia can happen for very high dose of Mebendazole (1500mg/day) Ref and so I expect that would also be the case for Fenbendazole when used in very high dose. This usually improves on stopping the medication. However, based on available info at normal dose I do not expect impact on bone marrow.
      Kind regards,
      Daniel

      1. Hi Daniel
        I’ve done 5 weeks of Joe’s 3on /4off protocol with vit A, E, k, and C and today I saw my blood CBC drop lower than last few months. The platelets were coming up a bit from 70’s to 120 but today dropped to 66. Same with WBC had climbed from 1.3 to 1.9 now back at 1.3. RBC are at 9.8 up a bit from 9.0-9.3,last 3 months. During this time I’ve done Laetrile, ozone and UVBI and HBO treatments too, as well as some key supplements. Lots of green juices and also mostly organic vegan meals. Just started RSO a few weeks ago but still a long way from 1gm a day. Thoughts?

        1. Hi Rmacgurn,

          I am not sure about the influence of ozone and UVBI on blood results … when my wife was doing a combo of ozone, high dose Vit C and Artesunate at a clinic in Germany her blood parameters were deteriorating. They all came back to normal levels once we stopped the combo. I always suspected Ozone as responsible but Vit C and Artesunate combo can also induce that. So the question is: what are the therapies (conventional and alternative) you introduces between the last blood test and the one prior to that. A time line indicating the blood results and corelated with the treatments started and stopped would very much help me and others readers so that we can share more thoughts with you on this.
          Btw, have you seen this? https://www.cancertreatmentsresearch.com/community/leukemia/mitochondria-inhibitors-help-improve-effectivness-of-conventional-therapies-in-chronic-myeloid-leukemia-cml/#post-695

          Kind regards,
          Daniel

          1. Hi Daniel
            Well about 3 months ago I added to by base protocols ozone and UVBI then 2 months ago added leatril and RSO. And 1 gm panacur-C Friday-Sunday. My blood was checked monthly or more often at mayo and Virginia piper cancer center.it was more or less stuck around 80 on platelets, 1.4 or less on WBC and 9.0-9.6 on RBC.
            Then I saw improvement in WBC’s and platelets starting in early May. Platelets up to 90’s and WBC 1.9. I continued to increase my RSO rice grains from 1×3 times. Day to 2x 3, than 2×4 times and restarted my IV’s of ozone uvbi and leatril and one of Vit C 30gm. I’m a long way off from 1gm a day RSO but could be there soon as I’m at 1gm in 4 days now. I had to return to Costa Rica so from May 25 to June 16 I had only leatril pills of 2,000 mgs day, and fruits and organic juices and supps plus panacur-C. I’ve now done 5 consecutive weeks of panacur-C and one 3 day use of another human de parasite drug. Last test in Costa Rica 15 days ago showed platelets at 123, RBC at 9.2 and wbc at 1.5. So the wbc were slipping from 1.9 to 1.5 now 1.3. It’s hard to know if anyone of these is the reason. I’ve read RSO can cause clotting and platelet issues. Not sure I’ve seen that with panacur or ozone/UVBI.
            Any thoughts ? I’m kind of hoping RSO can help me as on another FB site C.K.C. I found a guy says RSO cured his late stage leukemia.

  7. Hi Daniel,
    Some people said the vitamin E badly interact with Breast cancer. However, I found some information that only the alpha tocopherol did. May I get some advise from you?
    Thanks,
    Sammer

  8. Hi, We just found out 4 days ago my mom has lung cancer (mass) and lymph nodes affected as well as he in spine L5. Still awaiting biopsy to find out what kind of cells and PETSCAN. The have already told her she is stage 4 and not cureable. How would Fenbendazole work with Radiation and Chemo? They want to do Radiation on Mass right away.

  9. Hi Pnut21, sorry to hear, since they’ll likely want to do chemo you might want to check out Robert A. Nagourney M.D, he does chemosensitivity testing on bits of tumors in order to find out which chemo can be effective. He also wrote the book “Outliving Cancer”.

    1. Johan,
      So do you not think the regime that Joe Tippens used, using Fenbendazole would be ok for her to start using in conjuntions with other treatment plan?

      1. Sorry to have confused you. I know I didn’t address your question and that’s because I know very little about Fenbendazole. But since your mom just recently got her cancer dx and she hasn’t started chemo yet I wanted to let you know about this technique, chemosensitivity testing or functional profiling in order to find out how cancer cells respond when they are exposed to drugs and drug combinations. (https://www.nagourneycancerinstitute.com/cancer-faqs). A good start is half the battle!

        1. @johan: that is interesting and promising, but they ask for a large sample, about one cubic centimeter, for solid cancers. IMO cutting such a sample from a primary tumor is too risky (increase in metastasis), so a resected malignant lymph node seems the best option. I still don’t understand, from their website, how to keep the cancer cells alive, until the sample reaches their lab.

            1. @johan: thank you for the link; so you need to first order a “specimen transportation kit” from their lab; then the transport to the lab shouldn’t take too long: “within 24 – 36 hours of collection while the cells are still viable”.

          1. Ovidiu, in response to your question below, indeed that seems to be the best way to collect the sample. As for your concern about taking such a large sample of a tumor, they can also work with cancer fluids (pleural effusion/ascites).

      2. HI Pnut21, in my view, anything that may interfere with cancer cells and slows them down is good to be stop a few days before chemo and started after. Fenbendazole is part of this category so I would apply this rule. Kind regards, Daniel

  10. @Pnut21: when presenting the case, it’s better to give more accurate information, and always try to get such information from the doctors, for starters what type of lung cancer it is. You didn’t specify the size(s) and / or volume of the lung “mass”, the number of affected lymph nodes, and size of the spine metastasis (which is probably the hardest to treat). If you’ll get a biopsy sample, it would be highly recommended to test it for possibly targetable mutations. You also didn’t specify from which country you are, and if you can afford to spend money on tests and medicines, other than those done by the public health system. You also didn’t specify if your mother was smoking, or was exposed to other carcinogens. You didn’t mention any blood tests, of tumor markers commonly used to monitor lung cancer.
    About Fenbendazole, while there are some credible reports about usefulness against lung cancer, before getting a lot more information about the particular cancer patient, it’s hard to give competent advice. And since Fenbendazole has a poor and variable bioavailability in humans, it may be useful in theory, but not in practice.
    About “Radiation on Mass”, what kind of radiation? Is it stereotactic radiosurgery or something else?

    1. I apologize, at the time I wrote that I gave what info I had. Today biopsy results came back and we were told she has grandular cancer of the lungs, non small cell, adenocarcenoma, stage 4.She will see the radiation oncologist hopefully next eeeek.

      1. @Pnut21: no need to apologize, to you this is new, and probably very stressful. Just remember to get as much useful information as possible, and share it when you ask for advice. From the oncologist you could find out which mutation tests are paid by the public health. In LUAD (lung adenocarcinoma), the most common mutations (determined from the biopsy sample, while it’s still fresh) are Kras, EGFR, ALK, Braf, Her2, etc. Common blood markers for LUAD are CEA (carcinoembryonic antigen), CYFRA21-1, NSE, CA 19-9, CA 125, etc. The oncologist should ask to perform such blood marker tests, since they are relatively cheap, and keep testing again the one which seems the most relevant, in order to monitor disease progression between CT scans.
        It would be helpful if you tried to answer some of the questions in my previous post. I suppose you have the CT scan, and interpretation of it.

  11. Having a low level prostate cancer, slowly rising psa of 4.6 , decided to try fenbendazole, sourcing from Safeguard Horse Dewormer, my question is about my plan to take this daily and not the alternating 4 on 3 off schedule that Joe Tippens has used …. my question is there a downside to every day use, aside the expense ? My layman theory is it will be more effective against cancer if used daily. I will also use a complex vitamin E supplement, will skip the CBD for now.
    Thanks for this well researched page, kanzanc.

  12. Interesting. I also found more info from files
    Fenbendazole products.pdf)
    at the facebook page
    https://www.facebook.com/groups/mycancerstoryrocks/
    which is devoted to fenbendazole.
    ——————–The dosage Joe took was 222mg of fenbendazole for 3 days on
    and 4 days off weekly. Joe was advised this to ensure optimal liver functioning. Some people do take it
    everyday for the first 2 weeks then drop down to the recommended 3-4 regime. Dosages up to 300mg
    have proven to be well tolerated.———————–

  13. Hi Daniel – have been fascinated by your article – having just read Joe Tippens account of his self-medicating with Fenbendazole.
    I have inoperable stage 4 bowel (colon) cancer, metastasised to my peritoneum. Had 8 rounds of chemo last year, drug free since then.

    I ordered 3 months worth of the Fenbendazole but have a problem with starting it straight away.

    Are you able to tell me whether having had an auto-immune disease (Sarcoidosis, in my lungs, 20 years ago, leaving them scarred) means I should not jump in right away? There is pitifully little research into Sarcoidosis, so I suspect the answer to this may be unknown. Can you help?

    Many thanks.

    1. Thank you Harrio. Auto immune reactions are based on up regulating glycolysis and MCT transporters. Using glyco inhibitors and MCT inhibitors should work against auto immune reactions. Fenbendazole seems to be also a GLUT inhibitor which means it should down-regulate glycolisis. So from this point of view Fenbendazole should help against auto-immune reactions. Adding MCT inhibitors such as Quercetin could further help to minimize potential auto-immune reactions. Kind regards, Daniel

  14. Daniel, Thank you for helping those of us who are in very difficult situations. Our special needs daughter has been diagnosed with Stage 4 liver cancer (after3 years of trying to find out what was wrong!!)! She is tube fed and weighs 60 lbs. at 30 years of age. My question is how we could give her the Fenbendazole and what dosage you would recommend? We fully understand that you are not recommending this medicine but we are most interested in it because she is not improving and we feel that we should try it. Thank you so very much for your work and compassion to help others. ❤️⭐️ janice

    1. Thank you Janice. I am so sorry you have to go through this. Regarding the dose, the rule that I always used was to start with 25% of the target dose and if everything is good move step by step (e.g. in 4-5 steps) to the target dose. The target daily dose is mentioned in the article above. Giving it via the tube is new to me but if I would have to give it via this route, I would probably buy the solution (Fenbendazole is found under different brands in different forms: granules, solution, capsules) or otherwise mix the granules with water. Adding fatty foods will help the absorption of Fenbendazole. Janice, have you considered trans arterial chemo embolisation (TACE) to treat the liver?
      If not, please see the following:
      https://radiologie-uni-frankfurt.de/content/e6796/e13478/e13775/e16256/index_eng.html
      https://www.cancertreatmentsresearch.com/case-report-hepatocellular-carcinoma-hcc-successfully-managed-with-tace/

  15. Hello.
    I am a 6.5 years liver cancer fighter. My first OP was in April 2013. It was an HCC as big as my fist.
    Then follow 3 more times surgery in the next 3 years. Until today I got 5 microwave ablatations and 17 Tace(mitomycin) by Prof Vogl in Frankfurt.
    In my opinion from all natural ways Im doing, the high dose rectal and hyperbar ozone therapy was the best way for me. The last 1 year Im in stable disease.
    2 weeks ago Im on the fenben protocol includes Gamma E, B1 and DCA.
    I give you more Informations until it works.
    By the way, 3 years ago I have got 13 Infusions 3BP don’ t helped me.
    I think 3bp only works in tace. But no one in germany will do this. Prof Vogl only gives chemo tace.
    I am so sorry for my bad englisch.
    Andre

    1. Hi Andre,

      Thank you so much for sharing the info with us. Your English is very good and today, with Google translator, there are fortunately no more language barriers. 17 TACE sounds like a lot indeed. It’s great that you can have access to prof Vogl’s treatments. Is this covered by the German insurance?

      Nice to know that you think and feel Ozone helps and 3BP did not help you. I think depending on tumor (size, location) and other know (such as dose, time, etc.) and unknown variables, 3BP helps some and do not hep others. 3BP TACE is good for some and not good for others. Same with IV. It’s an experimental treatment with important anti-cancer potential and the humanity still needs to understand how to use it in the best way.

      This may explain why 3BP was not effective enough in your case:
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4549759/
      “Therefore, therapeutic strategies should focus on both targets, glycolysis and mitochondrial OXPHOS. Even though some studies reported that mitochondrial OXPHOS is also one of 3-BP targets[185], 3-BP has been mainly demonstrated to be the most potent glycolytic inhibitor among various types of inhibitors. However, including our studies, the results of in vivo studies that have used human HCC cell lines did not exhibit complete remission, but showed only partial remission after 3-BP treatment[18,19,43-70]. One reason why 3-BP did not completely suppress tumor growth might be the low efficiency to suppress mitochondrial OXPHOS, the lactate shuttle, and high redox potential in cancer cells. To overcome the weakness of glycolytic inhibitors, the inhibitors to target mitochondrial OXPHOS and other involved mechanisms such as the suppression of ROS production, might be effective when used simultaneously with glycolytic inhibitors as a combination treatment.”

      Here is some relevant info shared by J, https://www.cancertreatmentsresearch.com/case-report-hepatocellular-carcinoma-hcc-successfully-managed-with-tace/#comment-7833

      Yes, Andre, please share with us anything that you learn and you think may help others. Thanks a lot and if you have questions please let me/us know.

      Kind regards,
      Daniel

      1. D, here is one that just came out that might help to amp up 3-BP.
        https://digitalcommons.wustl.edu/cgi/viewcontent.cgi?article=8534&context=open_access_pubs

        For me, the 3-BP era of cancer medicine really started with the melanoma patient. Injecting 50-100 mg liver TACE 3-BP and seeing a tumor shut-down (as with the liver patient) really is not that overly impressive. There are lots of other agents that could be effective in similar circumstances.
        https://www.ncbi.nlm.nih.gov/pubmed/24636230

        Yet, Injecting 2 mg/kg IV of unformulated 3-BP in saline and seeing the truly massive tumor response with the melanoma patient was overwhelmingly shocking to me. It was almost magical! Even the animal experimental results with systematic 3-BP administration seemed somewhat cautious about suggesting that this would be of help in humans.

        The straight 3-BP only gave about a 50% knockdown on LDH with the melanoma patient. Then they added in the paracetamol and LDH went to zero! I almost freaked out! That was truly truly shocking. When I posted this result on several cancer forums, at first they did not get it. They misread the figure. They thought there was only a slight 20-50% response. When I clarified that the tumor was essentially completely deactivated, the forum webmasters were absolutely furious with me and I was banned from a few of these forums because of it.

        Obviously injecting straight 3-BP in saline would now be thought fairly close to insanity and the original researchers are pushing towards more realistic formulations such as liposomal 3-BP etc, though the article with the melanoma patient certainly captured widespread interest in 3-BP. There are not many anti-cancer medicines that spring to mind that have such overwhelming anti-cancer effects as seen in the melanoma patient article and yet have almost no side effects.

        The first article cited above moves the 3-BP glutathione story another step forward. This time they do a dual combo with BSO shutting down gutathione and auranofin shutting down thioredoxin. This has me excited! the melanoma patient had a truly massive response when they added in the paracetamol to the 3-BP. Yet, this trick probably would not work for all patients. Some patients probably would have the thioredoxin backup cycle to counter 3-BP. Imagine what might happen if the dual combo shut down glut and thio and then you came in with 3-BP. Wow! Would be nice if they add a nanoformulations for knocking down glut and thio.

        1. Dear J,

          Thank you for your great comments and references. This reference is indeed very relevant to amp up not only 3BP but also 2DG, chemo and radio.

          I totally agree, the 3BP era for us started with the publication of the case in Egypt, that also gave us indication about the safety dose/time. That was a great reference point. Although some may consider close to insanity using experimental treatments such as 3BP, I still think that makes sense. What is insanity is not to make careful steps when stepping into uncharted territories.

          I also very much agree and expect that the effectiveness of 3BP will strongly be affected by the inhibition of anti-oxidants, based on what we have seen when my wife was using 3BP – ALA was essentially cancelling its anti cancer effect even when used a few days after.

          Your post here makes me want to write a post on this subjects as it is very relevant and less discussed in our discussion group here, that is ” inhibition of redox metabolism in cancer”. I promise I will do that soon, after finishing a family visit.

          Some of the points to be addressed:
          – reduction/inhibition of glutathione production
          – reduction/inhibition of thioredoxin production
          – reduction/inhibition of cysteine import via e.g. Sulfasalazine https://www.cancertreatmentsresearch.com/cancer-addiction-to-cystinecysteine-another-piece-in-the-puzzel/
          – reduction of cysteine ingestion via the Methionine Restricted diet https://www.ncbi.nlm.nih.gov/pubmed/30725411
          – combination of the above with glycolisis inhibitors and conventional theraphies

          Again, thanks a lot for the inspiring reference and words.

          Kind regards,
          Daniel

  16. Daniel, I am new to this blog having recently of using Fenbendazole for use as a treatment for cancer. This January my son as diagnosed with small cell lung carcinoma with metastasis to the liver, sacrum and hip bone and brain. He has had 4 treatments of chemo (carboplatin and etoposide) and immunotherapy (aterzolizumab) with on going treatments of immunotherapy every 3 weeks. He has also received radiation on his-lung, back, hip and brain. His pet scans have shown a slight improvement. He was also diagnosed with MS almost 5 years ago. He was on Texfidera, but was taken off once he started the chemo and immunotherapy treatments.
    My question to you is. Do you think he will benefit by taking the Fenbendazole. And if so, How is it taken and What amount is given? Any help or direction you can give us would be greatly appreciated.
    Thank you,
    Angela B.

    1. HI Angela,

      I am very sorry to hear about your son? What age is him? If he is an adult, the doses mentioned in the article above should be in-line with what the adults are using. For patients between 2 and 17, I discussed here how to calculate the dose vs. the dose for adults https://www.cancertreatmentsresearch.com/tips-on-treatments-a-list-to-be-constantly-updated/ If you need help with the calculation, please let me know and will do that for you.

      Kind regards,
      Daniel

  17. Hi Daniel, I have found your Blog very informative and helpful. I have stage 4 ADPA which is a very rare Adenocarcinoma. Started in a finger and then Axilliary Node, then mets to one lung. Within 3 months of surgery (lung re section) several more tumors showed up in the same lung, plus one in a buttock. After 3 sessions of chemo (Paclitaxel and Carboplatin) a CT scan showed mixed results, the smaller nodes were stable, the larger increased by 20%+. So my Oncologist is now trialling 4 sessions of Doxorubicin. In between this I read J Tippens blog and started to use Panacur c which I was able to obtain from an American supplier. (I reside in New Zealand and its not available here) I use it in combo with Vit A, VitD3,Vit C, Turmeric,Green tea extract,Rei-shi super mushrooms and Resveratol. I am unable to obtain CBD oil in NZ but am seeking a prescription to import 3 months supply from Canada. I also had a CT scan several days ago, and will get the results at my next Oncology visit( in 3 days) so am hoping for a better result, maybe its too early to see a result from the Fenbendazole? This is most likely my only chance to hold this cancer from faster progression, I have been given 3 to 4 months if the treatment is not helpful. Would you have any suggestions that may be helpful in my quest. Many thanks, Patrick.

    1. Dear Patrick,

      Thank you for your comment and question. I am sorry you have to go through this and hope that soon you will start to be better and better.

      Regarding conventional treatment I checked Aggressive Digital Papillary Adenocarcinoma and as you probably know, this is a short summary:
      – Surgery: if possible this is the best counventional treatment approach
      – Radio and chemo: according to this paper (Ref.)
      o all of the cases reported in literature lead to little or no improvement with no obvious benefit
      o there is no agreed standardization of the use of adjunctive chemotherapy or regimens, but agents used before and reported in the literature include cisplatin, gemcitabine, 5-FU, mitomycin, adriamycin, thiotepa, fluoxymesterone, carboplatin, paclitaxel, docetaxel, and VP-16

      Therefore, based on the above, if the doctor is going to try Doxorubicin, I would do the best to use approaches that could support Doxorubicin and try to increase the chance for effectiveness. Next to that I would add other treatment options that may add extra chances. I would also try Fenbendazole indeed.

      While I do not know many details regarding the tumor size, exact location, history, etc, here are some ideas that may be relevant:
      1. ADPA shows tumor overexpression of FGFR2 indicating that targeting the fibroblast growth factor (FGF)/FGF receptor axis might be a promising treatment for ADPA and probably for the overall group of sweat gland carcinomas. https://onlinelibrary.wiley.com/doi/full/10.1111/bjd.17446
      Example of drugs and supplements that interfere with FGF/ FGFR are listed in the Tble 1 of the following paper https://iris.unibs.it/retrieve/handle/11379/477703/37957/2016%20review%20Pharmac%20Res.pdf (or https://www.ncbi.nlm.nih.gov/pubmed/27013279)
      Of these, some that I consider most relevant are Tranilast, Celecoxib, Thalidomide, Curcumin, EGCG, Resveratrol. All have been shown to inhibit FGF. To make sure I address well FGF, I would use two drugs and two supplements, e.g. Celecoxib + Tranilast or Thalidomide and Curcumin+EGCG
      2. If the tumor is at the surface, I would also consider making solutions for topical administration such as that described here https://www.cancertreatmentsresearch.com/3-bromopyruvate/
      Whenever I would use a new substance, I would only apply on a very small portion of the skin to test the reaction. Other substances can also be mixed with e.g. 70% DMSO for topical applications.
      3. There are multiple intravenous treatments discussed on this website that may help, such as Salinomycin https://www.cancertreatmentsresearch.com/salinomycin/, Diflunisal https://www.cancertreatmentsresearch.com/diflunisal-2/, 3BP https://www.cancertreatmentsresearch.com/3-bromopyruvate/, Taurolidine https://www.cancertreatmentsresearch.com/taurolidine/, Curcumin https://www.cancertreatmentsresearch.com/curcumin-an-universal-cancer-treatment/, 2DG https://www.cancertreatmentsresearch.com/a-new-approach-to-improve-effectiveness-of-cancer-therapies-is-getting-ready-to-begin-human-trials/
      All can be accessible for anyone who really wants them and who has a medical trained person that is willing to help with administering them. However, they should be treated with care as they are experimental therapies, yet with high chance of anti cancer activity.
      Of these intravenous therapies, one of the easiest to implement that may help increase the effectiveness of chemo is 2DG https://www.cancertreatmentsresearch.com/a-new-approach-to-improve-effectiveness-of-cancer-therapies-is-getting-ready-to-begin-human-trials/ 2DG for intravenous admin is available at German pharmacies and if you have a doctor who is willing to help I can connect him with an academic team from US that will help him for free with relevant info for implementation of this treatment. Usually it’s given after chemo for 2 days via an infusion pump (in the same way as 5-FU chemo is given to patients).
      4. Fenbendazole and any other drug and supplement that is expected to reduce tumor activity should be stop about 3 days before chemo day, and start again during the chemo day
      5. Fasting before chemo may help reduce the side effects of Doxo and may help increase it’s effectiveness
      6. Combining glucose absorption inhibitors such as those discussed here https://www.cancertreatmentsresearch.com/glucose-absorption-inhibitors-to-inhibit-tumor-growth/ with mitochondria inhibitors such as those discussed here https://www.cancertreatmentsresearch.com/a-list-of-mitochondria-inhibitors/ may help. Of these, one combination could be Canagliflozin with Metformin
      When using more drugs, you can always check the interaction between the drugs here https://reference.medscape.com/drug-interactionchecker?src=google besides discussing that with doctors
      7. You can also contact Care Oncology Clinic and consider starting up this drug cocktail including Metformin, Doxycycline, Statin and Mebendazole https://www.cancertreatmentsresearch.com/drug-cocktail-that-could-double-the-average-survival-time/
      8. Doxorubicin that you are using is a weak basis, which means that there is a high chance for Doxo to be deactivated by the acidity around the tumor before getting into the tumor as discussed here https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/
      In order to minimize this chance, I would use strategies that would be alkalize the body. Some obvious ways to do that are using Sodium Bicarbonate, or Basentabs https://www.pascoe.de/en/products/detail/basentabs-ph-balance-pascoe.html prior to chemo. In addition, using proton pump inhibitors such as Omeprazole (this is easy to get) may help. I discussed this in more details here https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/ Chloroquine (an anti-malaria drug) combined with Omeprazole may further help increase effectiveness of chemos such as Doxorubicin https://www.ncbi.nlm.nih.gov/pubmed/16495919 https://www.ncbi.nlm.nih.gov/pubmed/29225688 I wrote some more words about Chloroquine here https://www.cancertreatmentsresearch.com/chloroquine-hydroxychloroquine/

      I hope these ideas help.

      Kind regards,
      Daniel

      1. Hi Daniel, Just completed my appointment with the Oncologist, and was informed re the CT scan results. He was surprised with the mixed results again, larger lung Tumor only increased in size by 1mm, two of the smaller lung tumors also shows a very small size increase, the 4th tumor decreased. He has decided to cease the Doxorubicin and will start a three weekly treatment of Oxaliplatin and Capecitabine, the Capecitabine taken in 4 x 500grm Tablets x twice daily for 2 weeks on one week off. At this time he has also applied to get me into a Car T Cell trial in Melbourne Australia. This may be difficult to achieve as Australian residents will obviously have first preference. My Oncologist tells me there have been some excellent results with Car T Cell therapy on solid tumors. I would be interested to see what you think on this? Also do you think it is ok to continue with the Fenbenzadole during the Oxaliplatin treatments. The other meds I will now be taking are Domperidone 10mgs x 3 daily (as required) and Loperamide (as req) x 4 daily. I also discussed the possibility of trialling 2-DG (Metrononic) but he believes this would be better done in a clinic where treatment can be administered and monitoring for possible side effect is covered. In his opinion this would not be undertaken by medical professionals in NZ. He would be ok with me going to Germany or elsewhere for treatment ( 2-DG), but as our family finances have already been stretched to the limit by treatment and tumor profiling cost this is not a good option. Many thanks, Patrick.

        1. Hi Patrick,

          Regarding your question on Car T Cell therapy, my general opinion is that new/experimental therapies, especially those in the immune modulation space, should be used only when no other options are available. That is because the humanity is still at the very beginning in terms of understanding how the immune system can be controlled, while marketing of the involved companies it’s way ahead of that.

          Kind regards,
          Daniel

          1. Thank you for your reply Daniel, My Oncologist is attempting to enroll me in a Car T Cell trial in Melbourne Australia. This is if the current Chemo is not effective, it will be the final option for me. He did outline the possible serious side effects of Car T Cell therapy, and told me that there have been a number of deaths believed to be caused by this treatment. Although I seem to be tolerating Chemo well and he is surprised that my level of general fitness and wellbeing (under the circumstances) has not declined, he still believes I do not have many months left. I am continuing with the Fenbenzadole combined with the herbals suggested. Regards…Patrick

            1. Hi Patrick,
              It doesn’t matter what that oncologist believes, just don’t allow his beliefs to become yours. Your belief can be to become healthy again, this way your mind can work towards that goal. My father-in-law is alive 16years after he was given 6 months (glioblastoma). You are not an average of some statistic.

              All the best,

              Johan

              PS. Here’s a list of supplements, you might want to consider adding some to your regimen:

              Artemisinin: 200 – 500 mg once or twice a day on an empty stomach or 2 hours after last meal, and with cod liver oil for better absorption. Intermittent dosing (4-5 days on/2-3 days off) 6 up to 24 months. Alternative: Artesunate
              Honokiol: 1-3 gr/day in 2 or 3 divided doses. Honokiol+Magnolol>95% or HonoPure
              D-limonene: 0.5-3gr/day, in divided doses.
              Ursolic acid: 0,5- 1gr/day divided in 2 doses (breakfast,dinner). Take with some coconut oil for better absorption. 4 week cycles (4 weeks On/1 or 2 weeks Off).
              Allicin: therapeutic amounts of stable Allicin in the bloodstream can be obtained by taking a supplement called Allimed.
              Citric Acid: 0.05 to 0.1g/kg/day with water and with meals (in 2 or 3 divided doses).
              IP6: 500mg – 18 g/day
              Turky Tail: Trametes or Coriolus Versicolor, 4 g twice daily.
              Panax Ginseng: 800-2000mg/day (in divided doses, morning, afternoon).
              C-phycocyanin: 0.8-1.6 gr/day in 2 or 3 divided doses or 4-8 g Spirulina/day (Spirulina is about 20% C-phycocyanin by weight.)
              Jiaogulan: 5-20mg/kg/day (1 kg =2.20462 lb) in 4 week cycles (4 weeks On/1 or 2 weeks Off). Take between meals. Rich source of dammarane-type saponins
              Triphala
              Ashwagandha
              Modified Citrus Pectin
              Bovine Tracheal Cartilage

              One strategy is to rotate/alternate supplements. To combine various supplements add one at a time, start with the lowest possible dose and gradually increase if no side effect is observed

              Here are some things you could do with diet:

              *Foods that kill cancer stem cells (CSC): 6-Gingerol(Ginger), Epigallocatechin-3-gallate(Green Tea), Curcumin(Turmeric), β-Carotene(Carrot), Delphinidin(Berries), Baicalein(Chinese Skullcap), Isothiocyanates(Cruciferous vegetables), Linalool (Mint), Lycopene(Tomato), Parthenolide(Feverfew), Perylill alcohol( Mint, Cherry, Lavender), Ursolic acid(Thyme, basil, oregano), Withaferin A (ashwagandha), Resveratrol(Grapes, plums, berries), Silibinin(Milk Thistle), Quercetin(Capers, onion), Vitamin D3(Fish, egg yolk, cod liver oil), Piperine(Black pepper), Guggulsterone (Myrrh Gum), Flavanoids

              *Cholesterol-Lowering Foods: some cancer cells are vulnerable to cholesterol -> eat foods rich in soluble fiber: Beans, Oats, Berries (BOB). Hawthorne berries. Flax seeds. Green tea.

              *Sugar restriction: Eliminate all processed and artificial sugars. Fruits are allowed but choose fruits with strong anticancer properties.

              *Glycolysis inhibition: Turmeric, Graviola, Cardamom Spice, Ginger, Quercetin, Resveratrol, Apigenin, Citric acid

              *Reduce lactate levels: magnesium supplements (best taken with food in evening), Top 10 List of High Magnesium Foods, nettles(extract, tea), lemon juice (citric acid), Green tea (extract), Saffron, KD

              *The ketogenic diet(KD): eating a low-carb diet will cause the body to start burning fat(ketones) instead of sugar(glucose).

              *Time Restricted Eating

              *Inhibit glutamine uptake: green tea (egcg), ashwagandha, peppers

              *Increase NK cell activity: reduced lactate levels improve NK cell activity, enzymatically modified rice bran, blueberries, Brolico(this is a supplement), melatonin(as a supplement, also in foods like pistachios, lentils) Panax ginseng, cardamom & black pepper (work synergistically) Turkey Tail, Active Hexose Correlated Compound, zinc(1 hour before breakfast or before lunch), Modified citrus pectin{study}.

              *Eating enzyme-rich foods and adding an oral enzyme preparation (in between meals) to your diet plan might be very helpful at eliminating cancer cells.

              *Limit the metabolic flexibility of cancer: rhubarb (extract, tea)→Metformin enhances the effects of emodin, berberine

              As you can see it’s fairly simple to implement a combination or all strategies combined. The KD could be done intermittently, for example, a few days once a month.

        2. Hello Patrick,
          I have contacted PeterMac about their Anti-Lewis Y Chimeric Antigen Receptor-T Cells (LeY-CAR-T) in Patients With Solid Tumours (LeY-CAR-T) – is this the one you are interested in?.

          Raymond
          Sydney

          1. Hello Johan,
            Can I ask if your post to Patrick of June 14, 2019 AT 3:47 AM – is it specifically to treat glioblastoma multiforme (GBM)?
            Thank you
            Raymond

            1. Hi Raymond, no it isn’t specific to GBM, I’ve posted about that on another thread.
              Regards
              Johan

          2. Hello Westie, yes this is the trial that my oncologist is attempting to enrol me in. I have not yet had a response to indicate success in joining the trial. Here is hoping.

    2. Hi Patrick,
      Since you’re already using VitC and Green Tea you might want to consider adding lysine to that mix.
      There are studies that show the anti- mets potential of adding lysine to catechins:
      https://www.frontiersin.org/articles/10.3389/fphar.2017.00869/full
      https://www.dr-rath-foundation.org/2017/06/natural-eradication-of-cancer/

      There could also be anticancer benefit of taking vitamin K in addition to vit C
      http://www.medsci.org/v05p0062.htm

      There’s a product from NZ that combines VitC, K and lysine:
      CK3 Liposomal Vitamin C
      Vitamin C in combination (at 100:1) with K3 and lysine
      https://bushlore.co.nz/product/ck3-lipoic-acid/

      Since you’re using turmeric potential synergies could be obtained from combinations with green tea, which you’re already taking, Berberine, Boswellia.

      Regards

      1. Thank you for your assistance and suggestions Johan, I will certainly purchase the Vit C combo from Bushlore and add it to the daily intake. Regards…Patrick

      2. thank you for the info and assistance Johan. I have today added Boswellia extract and Bioperine to my regime. Will try and remove all refined sugar .. with a sweet tooth it will take time. Regards Patrick

  18. Daniel….I too am fascinated by this article. Background: Feb 11, 2019. Husband (56, nonsmoker) has NSCLC adenocarcinoma, mets to 1 lymph node, rib, 5 bones in pelvic area, plural effusion. Positive for EFGR and TP53. On targeted therapy Tagrisso 80mg. Have added the COC protocol since May 26th. We have scans scheduled for tomorrow (6/14). I would like your thoughts on adding Fenbendazole to his protocol. We feel that the Mebendazole is not enough. Question: To your knowledge with adding Fenbendazole to the COC protocol and the Tagrisso, would there be any concerns to worry about…..liver?, kidneys?, anything else? If we did add it, what would your recommendation be with dosage…how much, how often? In your opinion, would you add the rest of Joe’s protocol with the COC protocol and Tagrisso? I am FOCUSED on keeping my husband alive and well. My mother was diagnosed with NSCLC two days after my husband, stage 1. She had surgery for removal of 20 percent of lung. Developed complications after surgery and passed away……if I only knew one month ago what I know now, she could have still been with us. Please know how much people like us appreciate your willingness to share your information!!! Bless You!

    1. Dear Crystal,

      thank you so much for your kind words. I am glad that you find the information shared here useful.

      Indeed using Fenbendazole for NSCLC may be a very good idea. Here is a very recent paper (June 2019) by National Cancer Center Research Institute from Japan stating the same:
      Drug Library Screen Reveals Benzimidazole Derivatives as Selective Cytotoxic Agents for KRAS-Mutant Lung Cancer

      Answering your questions:
      – I do not expect major toxicity from Fenbendazole – the Statin included in the COC protocol has a higher (liver) toxicity. I do not expect any major interaction between Fenbendazole and those you mentioned. However, whenever you introduce a new drug, always start with a lower dose and move to the target dose in a few to several steps. For example, if the target dose is 1g, I would start with 250mg and next day move to 500mg, followed by 750mg and finally 1g, if no special reaction is observed.
      – Regarding the dose and admin strategy, I would use the same as Joe, i.e. 1g granules (containing 222mg Fenbendazole) each day, 3 days ON and 4 days OFF (please see the details in the article above and if you still have questions please let me know). The three additional supplements used by Joe are easy to access and cheap and taken in low dose, so I would add them.

      I am so sorry to hear about your dear mom and now the challenges with your dear husband. I very much hope that the treatment approach you are implementing will help and push the tumors away. Whenever you come across other relevant treatments/info please share them on this website so that we could help others as well. Blesses to you too!

      Kind regards,
      Daniel

  19. Hallo Daniel.
    Ja, die Tace bezahlt meine deutsche Versicherung. Ich hatte vorgestern die 18 Tace bei Prof Vogl. Es geht mir aber gut.
    Meine Biopsie sagte das ich keine p53 gene habe sondern im Übermaß cd34.
    Macht es dann überhaupt Sinn wenn ich das fenben protocol nehme? Oder wäre mebendazol das bessere Medikament. Fenben soll ja p53 stark hemmen.
    Vielen dank lieber Daniel.
    Grüße, Andre

  20. Sorry To bother you. My name is Weber I live in Rio de Janeiro, Brazil. I am a carrier of prostate cancer with bone metastasis. My bone metastasis is very advanced, I want to know if fenbendazole can help me to stop the advanced of bone metastasis. Can I use the oral solution? Do you know other person, besides Joe, who succeeded using fenbendazole?
    Thanks,
    Weber

    1. Dear Weber,

      I am so sorry to hear about your challenges. I hope you will be better soon.

      Fenbendazole could be a relevant option that is easy to access and implement. In addition to that you may want to have a look at the following:

      1. Drugs and Supplements relevant to prostate cancer:
      https://www.cancertreatmentsresearch.com/prostate-cancer/
      https://www.cancertreatmentsresearch.com/community/prostate-cancer/
      Here you will find a list of supplements that are very relevant to prostate cancer.

      2. Post on Zinc as a cancer treatment relevant to Prostate cancer https://www.cancertreatmentsresearch.com/unlocking-zincs-potential-to-fight-cancer/ – this needs to be combined with Quercetin in order to be effective – Quercetin is an extract from onion that can be found as supplement online and is taken between 1g and 3g/day

      3. If you have a doctor willing to help you with giving 2DG metronomic, with or without chemo, please let me know and I will connect your doctor with the academic team in US to support him with info on that https://www.cancertreatmentsresearch.com/a-new-approach-to-improve-effectiveness-of-cancer-therapies-is-getting-ready-to-begin-human-trials/

      4. As shown by Don https://www.cancertreatmentsresearch.com/a-visitor-story-healing-from-stage-4-prostate-cancer-with-fasting-and-juicing/ diet is very relevant in cancer, specifically for prostate cancer. In this case, next o avoiding sugar, I would specifically avoid fats (cholesterol is the basis for hormones), and red meat (as it contains higher amounts of glutamine which is highly relevant for prostate cancer cells).

      5. Supplements that are very relevant for Prostate cancer are Prostasol and Nutrition 2000 – both are acting as ADT (some of the people with whom I am in contact used them and saw positive results)

      6. Basentabs supplements found at online shops in Europe are also very good against prostate cancer.

      7. Another approach that may help for prostate cancer is discussed here https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/

      8. Some years ago I was in contact with a cancer scientist and prostate cancer patient who was managing his PSA with 3BP (he was taking it orally mixed in water as discussed here https://www.cancertreatmentsresearch.com/3-bromopyruvate/). He also stated that he had good results with DCA https://www.cancertreatmentsresearch.com/dichloroacetate-dca-treatment-strategy/

      9. ALA+HCA may be also a relevant strategy for prostate cancer https://www.cancertreatmentsresearch.com/another-weak-spot-of-many-cancer-cells-atp-citrate-lyase-inhibition/

      I hope this helps. If you have questions, please let me know.

      Kind regards,
      Daniel

  21. Hello Daniel,

    Some worrying finding on Mebendazole (MBZ) and Fenbendazole (FBZ) – which seems to increase IL-8 expression significantly.
    https://www.ncbi.nlm.nih.gov/m/pubmed/20848085/

    IL-8 is an important proangiogentic factor when it comes to formation of liver mets from various cancers.
    https://www.ncbi.nlm.nih.gov/m/pubmed/12167573/

    The reason for my interest is my friend have had growth of liver mets (new) after start of FBZ and MBZ.
    Also my friend started Clindamycin which can be a problem too in regards of angiogenesis.

    Kindly let me know your thoughts.

    Thank you
    Raymond

    1. Dear Raymond,

      Thank you so much for your good question. I read the article you shared here and other related references and at this point my opinion is the following:

      1. While on Fenbendazole there is not enough info to make a detailed statement, benzimidazoles such as Mebendazole are known to induce liver toxicity but that is rare and when that happens it takes place in a higher dose range and for longer term usage. Examples that are discussed in the article you cited are:
      – “Bekhti and Pirotte (1987) described a case of acute hepatocellular injury in a patient treated with MBZ 600 mg/day for echinococcosis.”
      – “Seitz et al. (1983) and Junge and Mohr (1983) reported MBZ-induced hepatic injury, and the liver biopsy of the patient revealed hepatocytic necrosis and portal inflammation with eosinophils during long-term (49–60 days) and high-dose (2–3.5 g/day) therapy with MBZ.”

      2. When this rare event is induced, the paper you cited suggests it may be due to a release of IL-8 and TNFa triggered by benzimidazoles. I agree that even if inflammatory events at the liver happen only in rare cases and at high doses, we should be aware of that, specifically when dealing with liver mets.

      3. While I would keep in mind the above, regarding the possible release of IL-8, for most of the patients and at a normal dose I would not be worried of possible pro-angiogenesis effects induced by benzimidazoles. There is actually literature suggesting they have anti angiogenesis action https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4096024/ Of course this is theory, but beyond theory we have a case report published in the literature, where Mebendazole showed strong anti cancer action. That was in a patient with a large and highly active adrenal cancer which is known to depend strongly on angiogenesis. And Mebendazole alone succeeded to stop the tumour growth and even reduce that.
      In addition, this more recent article on benzimidazoles (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5881671/) reports some results that are contradictory to the results from the article you cited.
      Here are a few more articles addressing the immune modulation mechanism by Mebendazole:
      https://www.ncbi.nlm.nih.gov/pubmed/28472897/
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6089388/
      https://www.ncbi.nlm.nih.gov/pubmed/30112108
      https://www.ncbi.nlm.nih.gov/pubmed/31010428

      In conclusion, I think it’s a good idea for the cancer patients with liver mets to be extra careful when using benzimidazoles. Nevertheless, please note that there is a report on a cancer patient with liver mets experiencing partial remission of the liver mets while on Mbendazole https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/#comment-4142

      Kind regards,
      Daniel

      1. @Ovidiu: Thank you very much for your most valuable feedback. Your advice on Nitroxoline is humbly noted. I am very encouraged by your impressive 7 years ago experience with NSCLC. Would you mind to share with me in this forum (or privately if you wish) your current treatment regime so I can hopefully reach my 7 years milestone?. Recently, I started Bevacizumab (Avastin) 15 mg/kg to treat my 2nd occurrence of brain mets. I am now attempting to block as many pathways as possible to minimize resistance to my current TKI: Capmatinib.

        I am considering this treatment to minimize the chances of further brain mets (in the event Avastin doesn’t work) – Doxycycline, Azithromycin and vitamin C (DAV) : a potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs)
        Fiorillo, M, Tóth, F, Sotgia, F and Lisanti, MP 10.18632/aging.101905
        https://usir.salford.ac.uk/id/eprint/51224/1/6atWoHSEhWbfbMtj5.pdf

        I know of a person who has Glioblastoma (GBM). After a new spot was seen in March 2019, her Neuro-Oncologist prescribed her with Doxycycline 100mg per day, 250mg Azithromycin per day and I.V. Vit C about 30g and worked up to 70g per week (based on 93 pounds person) – after this treatment, no new growth was seen.

        @Daniel:
        @Ovidiu:
        Can I ask your opinion about using GMB treatments against brain mets (from NSCLC)?.
        I noted that Avastin was originally used to treat GBM.

        Thank you sincerely for you help.
        With Gratitude,
        Raymond

        1. There have been quite a few posters lately with lung cancer. The Turkish clinic has reported quite startling good results in LC using a metabolic approach. Their reported suvival times of their patients were multiple times higher than what has been reported with typical care.

          1. @Jcancom: Thank you for your feedback – I believed you are referring to this Turkey based treatment centre https://chemothermia.com.

            I also understand that Dr. Kleef http://www.dr-kleef.at/en/our_institute has reasonable success in treating Stage IV disease. One of the patient: Layla http://teamlayla.blogspot.com/ being treated by Dr. Kleef, Dr.Jason Williams http://www.williamscancerinstitute.com/about-us/ and Dr. Mark Rosenberg http://www.newhopeforcancer.org/.
            Dr. Kleef IL2/fever treatment is super expensive.

            I recently got hold of Coley’s toxins from New Zealand – is a rebirth of MBVax from Canada https://www.bloomberg.com/research/stocks/private/snapshot.asp?privcapid=45245978

            For more information about The Reinvention of Coley’s Toxins:

            http://www.volumesdirect.com/detail.aspx?ID=5544

            https://amzn.to/2xeY4LD

            I am trying to initiate the fever treatment like Turkey or Austria.

            Raymond

          2. Westie, thank you for the article on the triple negative patient. Many of the strategies noted in the article are what we have also found to be quite helpful (metronomic dosing, chaotic/complex dosing, multimodal etc.)

            Very startling how effective this formulation of wheat germ agglutinin was.
            WGA is cationic and is attracted to cancer cell surface glycans.
            https://www.ncbi.nlm.nih.gov/pubmed/?term=28521959

            Infrared heating pads penetrated much deeper than I would have imagined (3 inches!!!).
            Cancer cells cannot survive much past 115 F, normal cells can.
            These pads can be bought online with precise 1 F temperature control from ~100F to ~ 160F.
            Seems like a great one!

        2. @Westie: I’m afraid there has been a misunderstanding… 7 years ago I was trying to help my father, and any possibly helpful addition (found by me, by searching Pubmed and other sites) to the standard chemo, I was testing it on myself first, to determine the tolerated dose. Unfortunately, my father’s lung cancer was one producing extremely high CEA levels, and I now know that there was nothing back then, that could have really saved him. Even today it would be almost impossible to source the drugs, that would help such a patient.
          We only used Nitroxoline (low dose) for a week, the second week of a Carboplatin and Vinorelbine (3 weeks cycle), and got CEA stabilisation (CEA blood test was performed about once a week). But for the third week we didn’t use it, I wanted to see if the CEA will raise by ~15%, as it usually did every week in which chemo wasn’t applied. To my unpleasant surprise, the CEA rose by about 30%, and I couldn’t figure out why… Based on later published papers, we should have continued with low dose Nitroxoline, maybe supplemented with a proton pump inhibitor. For a maintenance regimen, I believe metronomic (oral, but at lower dose) Vinorelbine, plus Nitroxoline and a PPI should be tested, but so far nothing was published.

          Regarding a more effective (classic, not targeted) regimen for advanced NSCLC, I would suggest nab-Paclitaxel (if you can afford it, or is paid by insurance), enhanced by Azacitidine and Lansoprazole.
          A phase I trial of azacitidine and nanoparticle albumin bound paclitaxel in patients with advanced or metastatic solid tumors. PMID: 28881739

          About Silver nanoparticles, I suggest caution: while they can be very effective against some cancers, if you’d take a large dose (selectivity is about 2), those Ag-NPs could kill you, not just the cancer.

          1. @Ovidiu – thank you very much for pointing out the potential higher risk of Ag-NPs. I agreed that one should weigh up the risk and reward/benefit. If there are other alternative treatment approach that has a lower risk and similar benefit as Ag-NPs, then I should definitely give those other alternative a higher consideration.

            Raymond

            1. @Westie: my point with Ag-NPs is that you have to know exactly the sizes of the NPs, in order to properly dose them. With the right dosing, they can affect the cancer cells, but not so much the normal cells. However, homemade Ag-NPs appear to have 2 different sizes, and the cytotoxicity, both against cancer and normal cells, depends on NP size.
              I would suggest buying NPs of a certified size, in order to be able to properly calculate the right dose.

            2. “The reference dose, published by the United States Environmental Protection Agency in 1991, which represents the estimated daily exposure that is unlikely to incur an appreciable risk of deleterious effects during a lifetime, is 5 µg/(kg·d).” wiki

              “A current is applied until the metal content of the water measures 0.09-0.15 ppm using a water. … He ingested 120 mL of the solution daily for 3 months during which time he had significant clinical improvement.” Cited Article

              1 ppm = 1 mg /kg
              Here 1 kg ~ 1 L as aqueous conditions are involved
              Thus, 1 ppm = 1mg/kg ~ 1mg/L
              Using 100 mL, 1 ppm = .1 mg
              With 0.1 ppm = 0.01 mg = 10 micrograms

              From the wiki quote above a 50 kg individual could consume 250 micrograms of silver safely over the long term (as per EPA guidelines).

              The dosing used in the article appears to have been exercised appropriate caution.
              It is not entirely clear to me, though, whether the EPA guidelines was referring to this specific formulation of silver, or whether an enhanced therapeutic effect would be possible by selecting different sizes of silver nanoparticles as suggested by ovidiu.

  22. Dear Daniel,

    In my recent FoundationOne test, the Genomic Findings for NSCLC Stage IV are:-

    #MET exon 14 splice site (2888-18_2888-7del12)
    #MDM2 amplification
    #MLH1 Q537
    #TP53 E285K

    I am currently on the 2nd line TKI: Capmatinib (INC280) to treat MET exon 14. I had progression on the 1st line TKI: Cabozantinib, hence TP53 pop up as a new finding (in resistance).

    Do you know of any inhibitors that can be used to target MDM2 amplification, MLH1 Q537, TP53 E285K ?

    Thank you sincerely for your help.
    Raymond

    1. Dear Raymond,

      Expressions like these will be up and down as a function of time and cell population. This is why I prefer to consider treatment angles that are more constant, and this is why I often discuss the metabolic angle. However, answering your question on MDM2, here is a list of references indicating several FDA approved drugs that may be relevant, including those like Mebendazole/Fenbendazole:

      – MBZ appears to be effective through p53-dependent and independent pathways. For example, in lung cancer cell lines, it was found that MBZ treatment caused post-translational p53 stabilization and the downstream expression of p21 and MDM2 http://ecancer.org/journal/8/full/443-repurposing-drugs-in-oncology-redo-mebendazole-as-an-anti-cancer-agent.php

      – Identification of FDA-approved drugs that computationally bind to MDM2 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3448857/

      – Benzimidazoles Downregulate Mdm2 and MdmX and Activate p53 in MdmX Overexpressing Tumor Cells https://www.mdpi.com/1420-3049/24/11/2152/pdf-vor

      – Nitroxoline induces cell apoptosis by inducing MDM2 degradation in small‐cell lung cancer https://onlinelibrary.wiley.com/doi/full/10.1002/kjm2.12051

      Kind regards,
      Daniel

      1. Dear Daniel,

        Thank you sincerely for your most valuable feedback – it is most valued and appreciated.
        I will study them and discuss with the doctor and see what he says.

        As always, with gratitude,
        Raymond

      2. @Daniel: Nitroxoline is unlikely to be effective (at least alone) against NCSLC, since it has a short half-life in blood, and concentrates in urine. My experience with it (7 years ago) is that the common dose of 600 – 800 mg / day is tolerable, but gives a bit of liver damage, which is manageable. I believe a half dose (300 – 400 mg / day) should be well tolerated long term, and usable as part of an anti-angiogenic regimen.

      3. @Daniel: the expressions of oncogenes and tumor suppressors don’t just go up and down, the populations can change depending on treatments. In this particular case, there is a MET oncogene, one tumor promoter MDM2, and 2 silenced tumor suppressors MLH1 and TP53 (the most important one). In order for the experimental Capmatinib to really work, my understanding is that the tumor suppressors would have to be reactivated.
        Possible solutions would be a Nutlin prodrug (Idasanutlin) and maybe Oxaliplatin. Nutlin could inhibit MDM2 and activate P53, while Oxaliplatin seems to activate P53 even if MLH1 is silenced.
        Preclinical evaluation of the first intravenous small molecule MDM2 antagonist alone and in combination with temozolomide in neuroblastoma. PMID: 30536898

  23. Hi Daniel

    We purchase Panacur from an ag store for our horses, which is a paste. However, I did a search tonight on duckduckgo.com and am finding that there are several sites which carry the canine wormer. Just a thot for those who are having probs getting a hold of the product.

    Any chance the paste could be used as well? Also, if someone is using multiple modalities, will the Panacur C continue to work as stated, or will there be a conflict between the various modalities?

    Thanks for your time, in advance.

    BlueLinen

    1. Hi BlueLinen,

      Thank you for your question and sharing the info.

      As long as the same amount of active ingredient is used (in this case Fenbendazole) It should not matter what product is used. However, it may be some difference of bioavailability in humans depending on whether it is a solution, paste or any other type. Since these products are made for animal use, we do not have references on the use in humans and their bioavailability depending on product type. This is why, if possible, I would stick with the approach/type/brand used by Joe and described above, as it seems that worked for some. Regardless of the band, I would also try to add some fats in order to increase the chance for absorption (this type of drugs is not so well absorbed as also discussed in the post on Mebendazole).

      Kind regards,
      Daniel

    2. Panacure C is just a brand name for Fenbendazole. I buy the Safe-Guard brand of Fenbendazole from Chewy.com. It’s half the price of Panacure and it’s the exact same thing. Most feed stores carry Safe-Guard Fenbendazole in the dog medicine section. It comes in a box of 3 single dose packets of powder form that you can mix into some yogurt or pack into gel capsules. You can buy gelatin capsules online.

  24. Daniel,

    I have stage 4 breast cancer with mets to multiple bones and liver. I’ve been on Taxol infusions for a year now (3 weeks on, 1 off) and a PET scan in Oct 18 revealed that the cancer was not active. I’ve had follow up CT scans in March 19 that show no change in size or location so am hopeful that it is still inactive since no way of knowing without the PET scan.
    I’ve been wanting to start Joe’s protocol and have already been taking the turmeric and CBD for a year now since my diagnosis. I brought it up with my oncologist yesterday and she is “okay” with the Fenben but said absolutely not on the Vitamin E because it interferes with the Taxol.
    I had not heard this before- my questions are:
    Do you have any information on E (antioxidant) interfering with Taxol and is there a benefit to starting the protocol, even without the E, if the cancer cells are indeed inactive?

    1. Dear Walker,

      I think the oncologist asked you to avoid Vit E during chemo due to the fact that Vit E is a strong anti oxidant known to cancel out some of the pro oxidant action of chemo. Here is an example of a paper where Vit E is discussed as a possible treatment to prevent Taxol induced neurophaty https://cdn.neoscriber.org/cdn/dl/608c388c-04f1-11e8-9dce-9319fb34295e

      Here is a drug interaction checker where you can see why your oncologist reacted to Vit E https://www.drugs.com/interactions-check.php?drug_list=1778-1147,2306-0
      In general, my opinion is that antioxidants should be avoided during chemo, several days before and after chemo. So I think the suggestions of your oncologist makes sense.

      Since Taxol is used even if cancer cells are inactive, I think it makes sense to add Fenbendazole as well. Fenbendazole acts in a similar manner as Taxol just that it binds at a different location so in theory it should help to achieve better results compared to Taxol alone.

      I hope this answers your question.

      Kind regards,
      Daniel

  25. Hi Daniel and All,
    ” In-human activity and pharmacology of homemade silver nanoparticles (SNPs) in highly refractory metastatic head and neck squamous cell cancer. ”

    ” Conclusions: Ingestion of a SNP solution is associated with complete regression of highly refractory head and neck cancer in the absence of other anticancer therapy. Ingesting silver solution causes a noticeable and nearly immediate rise in blood silver concentration. Urinary excretion is not a major path of clearance from the body. Given these dramatic results that may be attributed to SNP in conjunction with strong preclinical data, further patient testing of SNP should be done to confirm its safety and efficacy in head and neck cancer .”

    https://ascopubs.org/doi/abs/10.1200/JCO.2017.35.15_suppl.e17533?fbclid=IwAR05BElh6MCYVZ9x1j4xvhf2HXwM9FOBSZ_pyDcgoDU79ROGLlOIlqfm8gE

    Homemade silverparticles anyone?
    Quite intriguing results.
    Anybody with knowledge of replicating this DIY silver nanoparticles (SNPs) or comments on this?

    Thank you
    Raymond

    1. Hi Raymond,

      Thanks a lot! Great reference! Here is a link where the whole article can be accessed https://onlinelibrary.wiley.com/doi/10.1002/hed.25492

      There are a lot of anecdotal reports on this treatment approach, but having now a case report published by a US conventional Cancer Center is great.
      Given how easy is to produce, I would clearly try it next to any other treatment options that a patient may have.
      Here is a paragraph from the article, explaining how the patient produced the solution and what was the dose he used:

      “After the time of diagnosis of metastatic disease, the patient began to manufacture and consume an AgNP solution, with the following method of production. Twelve ounces of distilled water is placed in a glass container containing two bars of 99.99% pure silver. Three 9‐V radio batteries are hooked in series, producing a positive lead at one end and a negative lead at the other, resulting in a total output of 27 V of electricity. A current is applied until the metal content of the water measures 0.09‐0.15 ppm using a water tester, and this process averages 1 hour in duration. The resulting solution is strained with a mesh cloth to filter out remaining silver precipitate and the product is subsequently stored in a dark glass bottle.

      He ingested 120 mL of the solution daily for 3 months during which time he had significant clinical improvement. The patient was seen at our facility with a completely normal functional status and feeling much better than when he had started hospice. Repeat PET‐CT in November 2015, 3 months after pre‐hospice imaging and after ingesting AgNP solution, showed complete disappearance of all pulmonary and liver metastases as well as of previously seen nodes in the neck (Figures 2 and 3). This recovery and complete resolution of cancer at all sites persisted for 36 months and is ongoing.”

      Thanks again!

      Kind regards,
      Daniel

      1. Dear Daniel,

        Thank you for your ultra fast response – as always, your reply is most valued and appreciated.

        I am seriously considering adding the DIY / homemade SNPs to my Standard of Care (SOC) treatment (Avastin I.V. and TKI: Capmatinib) – do you think the SNPs can impair my SOC treatment and/or would the SNPs efficacy be reduced due to my SOC treatment?.

        Can I ask how to source the food/medical grade silver bars?. Do you have a website or contact details of any organisations/persons that can assist in sourcing food/medical grade silver bars?.

        Thank you again for your help!

        Take care,
        Raymond

        1. Dear Raymond,

          Based on the available literature SNPs act against cancer via pro oxidant mechanisms. Pro oxidant treatments are often used in combo with drugs such as Avastin or Capmatinib. So from a mechanism point of view I don’t see any reason why they should not be combined. However, those using the combo should have an eye on the potential pro thrombosis effects of SNPs https://particleandfibretoxicology.biomedcentral.com/articles/10.1186/s12989-019-0292-6
          and Avastin https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5004819/

          At this point I don’t know what would be the best supplier for the Silver bars. But this home remedy is so often used around the world, so that it should be relatively easy to find the info you need after a short search on the web. When you have a view on this could you please share that with us here? Thank you.

          Kind regards,
          Daniel

          1. Dear Daniel,

            Yes, I will definitely share the SNPs treatment here.

            Seems to be some safety discussion out there & taking silver ain’t risk-free.
            For instance:
            1) https://en.m.wikipedia.org/wiki/Argyria.
            2) https://www.sciencedirect.com/science/article/pii/S0022354915305128
            3) https://www.mskcc.org/cancer-care/integrative-medicine/herbs/colloidal-silver
            Reported (Oral): Accumulation of silver in the body causes argyria, a bluish-gray discoloration of the skin, which is typically permanent.
            Reported (Oral): Myoclonic seizures were reported in a 75-year-old man following self-medication with silver.
            Reported (Topical): Topical use of silver nitrate for burns may cause methemoglobinemia.
            Exposure to high concentrations of silver, such as in an industrial setting, leads to systemic toxicity.

            Raymond

            1. Hi Raymond,

              I was looking at the particle size (approx 3-12 nm) and concentration (0.09- 0.15 ppm) in the case study and compared it to a colloidal silver brand, Sovereign Silver, which I have used extensively. The Sovereign Silver has nanoparticles about 8nm in size but a higher concentration of 10pmm (here is some 3rd party testing on their particle size: http://www.silver-colloids.com/Reports/cpr03/cpr_03.html). Despite some of the negative safety reports out there on colloidal silver, I have seen people take large amounts (1/4 cup/ day for a few months of the 10ppm Sovereign Silver) with no ill effect over the short term and take more moderate doses 1-5 tbs/day for years. My understanding of cases of Argyria is that they have occurred in people taking in very excessive doses of silver salts or large particle silver over years. The Sovereign Silver site has information on safety and argyria which you may find useful, as well as an upper limit dosing ingestion chart from the Environmental Protection Agency (EPA).
              https://sovereignsilver.com/silver101/safety-toxicity/. I mostly have experience with the use of silver for intestinal infections. I do have some concerns with its accumulation in the brain over years of use, but personally would not be concerned over shorter-term use of low particle size silver as a cancer treatment strategy.

  26. D, this is exciting! And yet again the Warburg effect plays a part: lactate export creates a negative surface charge on cancer cells —
    silver ions (Ag+) are then attracted.

    Has this result truly never been noted before in patients?
    Silver has been used medicinally for thousands of years (the thousand year rule again!)

    And yet it is then called quack medicine.
    https://www.quackwatch.org/01QuackeryRelatedTopics/PhonyAds/silverad.html

    While entirely new chemicals that are dreamed up in a lab or assumed to be safe and effective after fairly limited human testing?

    D, could you baby walk us through this one?
    I am not sure what they meant about using a water tester to measure the ppm.
    Any specific online products that you might see that could fit the bill for silver bars?
    This could be a fun one to try out.

    1. J, thank you for pointing out the connection with the Warburg effect.
      In theory, I think its good to have the quackwatch-like researchers. In practice, the problem with most of them is that they are strongly biased even before starting research, and that is not constructive.
      Regarding your question, I will check and answer asap.

      Kind regards,
      Daniel

      1. D, I give up!
        Cancer treatment is always the Warburg effect and metabolic medicine!

        It’s amazing!
        So many times I have read something about chemotherapy and then they admit yes, even
        chemotherapy is often merely another metabolic approach.

        Thinking metabolic greatly simplifies the understanding process related to cancer.
        Cancer causes glycolytic overdrive –> great need for glucose.
        Glycolytic overdrive –> lactate export –> negative surface charge etc.
        There are a number of highly prominent weaknesses of cancer.

        ppm? With the silver nanoparticles, ppm is a fairly awkward
        concentration measure. Wonder if other ions could also be used?
        Perhaps coat the nanoparticles with chitosan for more precise targeting?
        perhaps bring along another chemical for the ride?

        Best Wishes, J

  27. Hi Daniel,

    What you you think about combining papaya seed powder (strong anthelmintic and antiamoebic properties and proven kill parasitic organisms but relatively safe) combined with with fenbendazole (relatively safe)? Wouldn’t the combination be more effective than febendazole alone?

    1. Dear,

      here, the major action of Fenbendazole against cancer is expected to be via microtuble dynamics inhibition. I am not sure what would be the anti cancer mechanism related to the papaya seeds to make a statement on the synergy potential. However, there is another perspective on cancer and that is related to the possibility that cancer is triggered by parasites and viruses. During the past years, I did saw many signs pointing towards that direction. Having this in mind, it would very much make sense for any cancer patient to cycle from time to time various antiparasites next to the core anti-cancer treatments. Papaya seeds is one of my favourite antiparasitic option. I actually used myself when I had such an issue – used a spoon of fresh papaya seeds every morning on empty stomach for about a week and all the symptoms indicating a parasite infection were gone. So I would indeed try it with or without fenbendazole, but probably not powder but fresh papaya seeds.

      Kind regards,
      Daniel

  28. HI Daniel,
    My wife Robin has Pancreatic cancer. Initially in 4/2018, she had a stage I b tumor removed in the tail of her Pancreas , they peformed a distal pancreatomy. She ws on Chemo ~Gemcitabine & Capecitabine, and Her last scan from 1 week ago shows that now it has come back and metastasized into her lungs and liver. Her oncologist has recommended wants to start back on chemo immediately, we are pending follow up /2nd opinion at Moffit cancer center in Tampa to review our options and talk about trials also. My question is do you think that Joe Tippin’s protocol could help her as an additional therapy to chemo?

    1. Hi jconnon,

      I am very sorry to hear that.

      Some months ago I was contacted by a lady stating that her husband, a pancreatic c. patient, was helped by Fenbendazole. She said the disease was stabilized for a long time frame and that was possibly due to Fenbendazole. She promised to write a post on the website as well but I havent seen that yet.

      From a theoretical point of view, Fenbendazole and e.g. Mebendazole should help the fight against pancreatic c:
      – pancreatic c may respond to ]drugs that are microtuble inhibitors since one of the major tool to fight panc c is Abraxane, a microtubule inhibitor. Fenbendazole and Mbendazole are microtubule inhibitors
      – in advanced stage pancreatic cancer is highly glycolitic and inhibitors of glucose transporters (GLUTs), such as Fenbendazole, should help.

      However, I would not take any of these drugs 3 days before chemo. I would start them during the chemo day and go on (according to the described treatment strategy) untill 3 days before the next chemo round.

      Beyond Fenbendazole you may want to go a little through the info shared on this website. Specifically metronomic 2DG https://www.cancertreatmentsresearch.com/a-new-approach-to-improve-effectiveness-of-cancer-therapies-is-getting-ready-to-begin-human-trials/ and Salinomycin https://www.cancertreatmentsresearch.com/salinomycin/ may help. These two are intravenous treatments.
      Metformin and Auranofin may also help to increase chemo effectiveness.

      If you have questions please let us know. Other contributors and myself will do our best to help.

      Kind regards,
      Daniel

      Kind regards,
      Daniel

  29. Dear Daniel,
    I cannot thank you enough for your quick response, all that you do, and this good advice.
    Her oncologist is recommending the following protocol/treatment:
    Leucovorin, Fluorouracil,Oxaliplatin,Irinotecan.
    Can you advise on if this chemo combination would act as a microtube inhibitor?

    I apologize for not being technically fluent or proficient in the cancer methodology.
    Are oncologists usually ok with patients taking this during chemo, would this disqualify her from any trials?

    We do have a 2nd opinion we are waiting on at Moffitt cancer center in Tampa FL, as I want to explore all options to fight this thing head on.
    We are looking into this trial, is this something that would help along with taking fenben?
    Title: Glufosfamide Versus 5-FU in Second Line Metastatic Pancreatic Cancer
    Modalities: Chemotherapy
    Drugs: fluorouracil, glufosfamide
    NCT ID: NCT01954992
    Phase: 3

    Thanks again,
    I am both terrified and hopeful at the same time,
    JConnon

    1. Jconnon, here is a pancreatic patient on forum who has what seems to have been a dramatic treatment response
      from an anti-metabolic approach.
      https://www.cancertreatmentsresearch.com/case-report-stage-iv-pancreatic-cancer-good-news-from-jess/

      We have now seen several other patients on forum who have had impressive responses by
      adopting a metronomic metabolic anti-cancer treatment strategy.

      A combined metabolic-chemo approach apparently can have a large anti-cancer effect.
      This is consistent with the highly encouraging results from the Turkish clinic with a pancreatic patient series.
      https://chemothermia.com/

      Best Wishes, Jcancom

  30. Since the bioavailability of Fenbendazole is low; I am wondering whether you would want to add piperonyl butoxide as part of the treatment since studies have shown that the anthelmintic efficacy in both animals and humans of a benzimidazole such as fenbendazole is potentiated by use with piperonyl butoxide
    See Link
    https://www.ncbi.nlm.nih.gov/pubmed/8866343

  31. Hi Daniel,
    First of all thank you for all you fantastic work! We all owe you so much because your research and info are most valuable.
    I would like to ask a question. I was diagnosed last year with T Cell lymphoblastic lymphoma, I received Hyper CVAD and the I underwent a stem cell transplant in November and I should still be in remission, fingers crossed. But with my type of lymphoma having the bad habit of relapsing quite quickly I feel I need to do all I can to stay cancer free. My question is : can I start this protocol as a preventive measure? And alternate it maybe with artemisinin as well? I am not on any medication apart from penicillin.
    Thank you so much and have a wonderful day
    Antonia, 40 years old, London

    1. Dear Antonia,

      Thank you for your words of appreciation and I would like to extend them to the contributors on this website as well.
      You could always consider trying some cycles Fenbendazole. As I was writing in an earlier comment, I think its a good idea for any cancer patient to do some cycles from time to time with anti parasites and antiviral medication/supplements, such as Fenbendazole, Mebendazole, Artemisinin, Ivermectin, etc, Cycles with antibiotics such as Doxycycline may be good, specifically in case of lymphomas but I would use only for active disease. Although in B-cell lymphoma, thsi is a nice example of the potential of Doxy https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5788673/
      I wrote sometime ago here, some of my views on prevention of recurrence that may be helpful: https://www.cancertreatmentsresearch.com/community/forum-to-discuss-treatment-protocols-and-drugsupplement-cocktail/reducing-supplement-protocol-berberine-metatrol-alamax/#post-828
      As I wrote in the post on Artemisinin, I would make sure to combine Artemisnin with the whole plant Artemisia Annua https://www.cancertreatmentsresearch.com/artemisia-annua-its-extract-artemisinin/

      Kind regards,
      Daniel

  32. Dear Daniel,

    I did Joe Tippens Protocol (without the CBD Oil) + 100 mg Mebendazole (daily) + 100 mg Doxycycline (daily) from 17/6/19 to 26/6/19 – my CEA dropped from 2.9 ug/L (18/6/19) to 2.4 ug/L (25/6/19). On 25/06/19, my AST 67 U/L (reference: 10 -40 U/L) & ALT 120 U/L (reference: 5-40 U/L). I stopped the above protocol and re-measured CEA on 2/7/19 – it went back up to 2.8 ug/L. Clearly he protocol has some impact on my CEA.

    I have now started Niclosamide (2g/day) [against my TP53 mutation] + 200 mg Mebendazole (daily) + 100 mg Doxycycline (daily). I did not use the above protocol because of the interactions between Fenbendazole & Niclosamide:- https://en.m.wikipedia.org/wiki/Fenbendazole .
    ” Drug interactions may occur if salicylanilides such as dibromsalan and niclosamide are co-administered. Abortions in cattle and death in sheep have been reported after using these medications together.[1] Abortions in domestic ruminants have been associated with concurrent use of anti-trematode therapeutic agents.”

    Q1) Have you come across any adverse reaction using Fenbendazole & Niclosamide?.

    As always, thank you sincerely for your help.

    Raymond

  33. Hello! My name is Sam. I was diagnosed with Limited Stage SCLC on March 28, 2018. Since then I have done 4 different Chemotherapy Drugs, 1 immunotherapy drug. Radiation on Lung, Brain & Hip. All of these treatments have been performed by the VA in Long Beach, CA. I have a PET Scan scheduled for some time in late August of this year. I am VERY interested in this Therapy……would love to talk to you further.

    1. sam, the Chemothermia clinic in Turkey has had notable success using their metabolically supported chemotherapy in NSCLC.
      In fact, the results reported in the below article caught the attention of a great number interested in metabolic medicine.
      https://chemothermia.com/news-research/lung-cancer-results-published/

      These results are actually quite startling!
      They are multiple times better than what has been reported from historical controls.
      And the basic approach is what others on the forum have being applying.
      Understanding cancer from a metabolic perspective might be of great benefit to you.

      I realize that this is not exactly your specific interest, though it was not easy to find similar research for SCLC.

      To give you a rough idea what we have been up to for the last few years, take a look at the results that Jess posted to this forum.
      https://www.cancertreatmentsresearch.com/case-report-stage-iv-pancreatic-cancer-good-news-from-jess/

      The figure posted is highly informative. After being diagnosed in October, 2017 high dose chemotherapy gradually brought down the tumor marker levels over a period of 4 months. In order to recover from the side effects a 4 month treatment holiday was taken. Tumor markers increased exponentially reaching a nearly unsustainable level. This is where a metabolic strategy was added to low dose chemo with a long list of often mentioned treatments from the forum: metronomic 2-DG, sali, 3-BP, hyperthermia, fasting etc.. The biomarkers rapidly collapsed.

      This general strategy has been used by others on forum with success, by the Turkish Chemothermia clinic and others. With our ongoing learning about other metabolic approaches, there would be yet more options available (e.g., silver, FB, etc). What we have seen is that cancer can only withstand so much metabolic stress before it becomes energy depleted and there is then a metabolic collapse. As I noted in an above post, FB appears to combine synergistically with DCA and 2-DG, so perhaps these combinations might be of interest to you. Dayspring in Arizona offers an integrated 3-BP treatment program which might also be worthwhile to consider.

      Best Wishes, Jcancom

  34. Hi Sam, Daniel is traveling right now. Are your questions about Fenbendazole or about other treatments on this site? If you are willing to post them, perhaps we can help you with answers. I hope that your treatment so far has been successful.
    Warmly,
    Shanti

    1. I just started 2 days ago!!! How does everyone prefer to take the Panacur C? Are there any side affects that have been reported? Also, I’m taking the Panacur C in conjunction with Irinotecan every 7 days. Are there any other people taking the Panacur C with Irinotecan?

      1. Hi Sam,
        There are quite a few people out there trying Fenbendazole and I haven’t seen people report issues on other forums, but I don’t know of anyone taking it with Irinotecan. How are you doing with it so far? The 222mg suggested by Joe Tippins three days out of the week seems unlikely to be an issue for most people. As Daniel mentions in this post, going up to 444mg/day for the three days could be beneficial if the 222mg is well tolerated. Are you having intestinal side effects from the Irinotecan? I think abdominal side effects such as loose stool or cramping would be the most common side effects, if there are any, possibly fatigue. It is always a good idea to monitor how you feel and back off the dosing if needed.
        We have the Fenbendazole but my husband hasn’t started taking it yet as we are implementing other things first, he does tend to be sensitive to medications, so we add in one thing slowly at a time.
        Best,
        Shanti

        1. Thank you for the reply, Shanti! You’re right, the Irinotecan does cause diarrhea (loose stools). I’ve been able to tolerate this Chemotherapy with little side affects, the most is fatigue. I took 222mg over 3 days and didn’y have any bad reactions. Do you or is it recommended to take 444mg of the Fenbendazole? also, do you have any other recommendations?

          1. Hi Sam,
            I am glad to hear that you are tolerating the Irinotecan well. Those of us who are using off label meds are a bit in the “wild west”, but we are willing to experiment because we are seeking a better outcome than the one handed to us by conventional medicine. So, would 444mg work better than 222mg? Logic would say yes, so if tolerated, some people choose to increase the dose. Joe Tippens also took vitamin E (Gamma E from Life Extension which contains all 8 forms of E), Curcumin and CBD, I would try to replicate that part of his protocol as well. I’m sure you have read his original story, but if not, it is here: https://www.mycancerstory.rocks/single-post/2016/08/22/Shake-up-your-life-how-to-change-your-own-perspective. While it is reported that some people have responded well to just this protocol, my sense is that many people will need a more comprehensive plan. A good place for a lot of people to start is with the Care Oncology drug cocktail:
            https://www.cancertreatmentsresearch.com/drug-cocktail-that-could-double-the-average-survival-time/
            https://careoncology.com/ -The clinic charges $800 for the initial consult, if I remember correctly, all the meds are less than $100 per month. There are follow up appointments every 3 months that cost around $250. All consultations can be done via phone and are with an oncologist. There is unlimited free access to a nurse for any questions that come up between consults. Of course, some people obtain these meds and do the program on their own. You would take Fenbendazole or Mebendazole, but not both together.
            There are a lot of other compelling treatments on this site, but the care oncology protocol is a good place to start while you look around and digest all of the info and decide what else you would like to include in your approach or if you want to involve an open-minded oncologist or go to a specialty clinic.
            It sounds like when you were originally diagnosed, it was with limited stage SCLC, did they later find mets in the brain and hip, giving rise to the radiation treatments?
            Warmly,
            Shanti

            1. Hi Shanti,
              First off, thank you very much for taking the time out of your day to share with me this information and helping me with all of this. Yes, you’re right. I was originally diagnosed with Limited Stage SCLC. First line of treatment was Cisplatin & Etoposide and radiation on the lung. The radiation I had on the brain was just preventative. It was just a precaution due to SCLC wanting to go directly to the brain. The hip, they found when I was doing the immunotherapy.

          2. Hi Sam,
            Two other therapies from this site that are over the counter and easy to implement are hydroxycitrate (HCA) + lipoic acid and colloidal silver. You can read about them here:
            https://www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/
            https://www.cancertreatmentsresearch.com/another-weak-spot-of-many-cancer-cells-atp-citrate-lyase-inhibition/
            For the hydroxyl citrate, the Super Citrimax linked to in the blog post has been discontinued by the company that sold it. We ended up ordering Super HCA from Douglas Labs since it was the product I found with the highest concentration of HCA, which means less pills: https://www.amazon.com/Douglas-Laboratories-Management-Regulation-Serotonin/dp/B000UJVKP0#customerReviews
            Regarding SCLC, while most cancers have a preference for sugar (glycolytic), it seems that SCLC is even more glycolytic than many other cancers. This means it uses a lot of sugar and produces a lot of lactic acid and it seem readily able to then reuse the lactic acid it produces to make more energy via the Krebs Cycle. I mention this because it is probably a good candidate for 3BP (as mentioned by Jcancom in his post). It is also a good candidate for pH therapy manipulation. If you have the resources, Dr. Rosenberg in Florida is knowledgeable on both. Here is some imaging on his website of a SCLC patient treated with salinomycin and “another drug” (which was likely 3BP): https://www.amtcare.com/offshore-clinical-trials.html. Of course, if you meet with him it is important to ask how long the remission pictured in the imaging lasted. Daniels Blog has great info on salinomycin and 3BP.
            If you don’t have the resources to see Dr. Rosenberg or go to Dayspring and you find you need more support than what you are currently implementing, you could take a look at Jane Mcleland’s book, “How to starve cancer without starving yourself.” Jane offers consults for a reasonable rate to help people determine a regimen.
            Warmly,
            Shanti

            1. Thank you Shanti. I will look at all of this information. BTW I started taking 444mg of Fenbendazole…hoping for the best!!!

            1. Shanti,
              I had a call from Jason at Care Oncology yesterday! Thank you for the information…I like what they are offering. He did say that they recommend the Mebendazole rather than the Fenbendazole. Any thoughts on that?

          3. Hi Sam,
            My thought is that, unless you have already noticed a therapeutic response to the fenbendazole, switching to the mebendazole should be considered since it is part of their tested protocol. No one knows which one is truly better, but we know that they work on the same mechanism and likely you will get a response to either if the cancer is vulnerable to it.
            Best,
            Shanti

  35. Bonjour Shanti,

    Est ce que l’on peut prendre du fenben avec de l’acide alpha lipoic et du dihydroxicitrate ? De plus mon médecin viens de me donner des corticoides, tout est il compatible ?

    Donc: AAL+garcinia+corticoides…. Est ce bon ??

    Merci beaucoup

  36. Salut Barraz,
    Je ne parle pas français, mais j’utilise Google Translate pour lire et répondre à votre message.
    Je ne prévois aucune interaction entre HCA, ALA, fenbendazole et corticostéroïdes. Bien que cela ne concerne pas la plupart des suppléments, vous pouvez vérifier les interactions médicamenteuses sur un site comme celui-ci: https://www.drugs.com/interactions-check.php?drug_list=1936-0,1535-0 (je ne suis pas savoir ce qu’est un site équivalent en français). Comme le fenbendazole est un médicament vétérinaire, vous pouvez utiliser le mébendazole à la place, un médicament similaire pour les humains.
    Meilleur,
    Shanti

  37. Hello,

    Does anyone know if Fenbendazole will work on dogs? My 7 year old Goldendoodle was recently diagnosed with lymphoma. My logic tells me if it worked on the mice in the Johns Hopkins lab it might work on dogs. Does anyone have any knowledge they could share?

    Ldr630

    1. Hi LDR,
      We certainly low fenbendazole is safe in dogs, and based on its mechanism of action i would think it would have any-cancer properties in dogs as well as humans. In the blog post above Daniel cites a study where fenbendazole worked against lymphoma cells, but only combined with select vitamins, vitamin E may have been the most important of these. I would ask your vet about vitamin E dosing for dogs. Joe tippens also used CBC, which you can get in animal formulations.
      Warmly,
      Shanti

    2. Hi again- I was typing on my phone and some words didn’t come through right. Should say *we certainly know fenbendazole* and *it would have anti-cancer properties*

    3. Hi Ldr,
      Thank you for the great question!
      My dog was just diagnosed with lymphoma and a friend forwarded this blog to me.
      Did you have a chance to find additional information?
      Did you have any success using it, if you did?

      I would so greatly appreciate all that you can share!

      Melina

      1. Hi Melina,

        I’m sorry to hear about your dog. My big beautiful goldendoodle had Stage 4 lymphosarcoma. I tried Fenbendazole (Panacur C) and Vitamin E with my dog but sadly I lost him two weeks ago. Perhaps his cancer was too advanced and aggressive for the Fenbendazole to take effect but I’ll never know the answer to that. I wish you ALL THE BEST! His death is still so raw and sad. Feel free to respond back if you have any questions. Did you watch the YouTube video of the woman who treated her shih tzu with PanacurC? I hope the video is real because I’m sure lots of people are watching it and are filled with hope.

        Ldr

        1. Hi Ldr,

          Thank you so very much for your response!
          My heart is aching so much for you and your doggy. I can’t even begin to imagine the pain.
          I am so truly sorry for your loss. Wishing that the Rainbow bridge had visiting hours :(((

          We went to see an oncologist today and starting the chemo treatment tomorrow. Time is critical for him.
          I did order the Panacur C, but it wont be arriving till 10-5.
          I tried to find the video you mentioned but did not find it.
          Will keep looking with the hope that it will give an idea for the dose and protocol. I believe the 3 days on and 4 days off is what I have to follow. My dog is about 80 lbs (down from 96 :(() and I got the 40lb dose. ??

          Thank you again Ldr,

          Melina

          1. Hi Melina,

            Thanks for your thoughts. My big beautiful Buddy was 85 pounds and I gave him 2 of the PanacurC 40 lb. packets mixed in his wet food. I got mine from Amazon and the delivery was fast. Below is the YouTube link I was talking about. I hope you can view it and I hope it’s legit. If the link doesn’t work just go to YouTube and look up Janice f panacur c.

            https://www.youtube.com/watch?v=PmWPxPSwmno

            Ldr

            1. Melina,

              I also gave Buddy 1 Vitamin E (400 IU) pill squeezed in his food. Good luck. Keep me posted. I hope your pup does well.

              Ldr

  38. Hi Daniel,

    Thanks for sharing this blog. I recently came across Joe Tippens blog and since then this has me curious and in awe.

    My Father-in-law was diagnosed with Non-Hodgkins Lymphoma earlier this year and then relapsed after 3 cycles of chemo (CHOP). He is currently on Romidepsin.

    Would be interested if you know of anyone who has been in a similar situation and taken the Fenbendazole and if it has helped in anyway.

    Thank you.

      1. Sorry this might be a stupid question and I apologise in advance for my ignorance.

        Can using FZ only work on cancers where there is a tumour present or can it work on cancers where its just there and there is no specific tumour.

        A bit if background – my FIL has stage 4 NHL which was detected in his bone marrow. I am pretty sure there is no tumour as such. I was always under the impression that lymphoma is in the blood and does not form tumours. But could be wrong..
        Can someone shed some light?

      2. Sorry this might be a stupid question and I apologise in advance for my ignorance.

        Can using FZ only work on cancers where there is a tumour present or can it work on cancers where its just there and there is no specific tumour.

        A bit if background – my FIL has stage 4 NHL which was detected in his bone marrow. I am pretty sure there is no tumour as such. I was always under the impression that lymphoma is in the blood and does not form tumours. But could be wrong..

        1. Hi- It is a good question, it is always important to ask when we have doubts, especially on such a critical topic as cancer. NHL starts in the lymph nodes, but it can spread to the bones, at which point it is stage IV. Since a main way that Fenbendazole works is by disrupting cell division, it could be helpful for any cancer with quickly dividing cells, including NHL. Here is a reference from the blog post above on Fenbendazole: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/. In the study, it worked best when combined with certain vitamins. I would consider using it with the vitamin E, curcumin, CBD used by Mr. Tippens if possible (see above).

  39. Dear Shanti

    I was first diagnosed with prostate cancer in 2007, had it removed and forgot about it, fast forward to 2018, PSA 411 ,metastatic prostate cancer in my bones, went to oncologist and began hormone treatments, and Zytega ( 1/4 of prescribed dose with a meal ) as of 2/2019 psa was .2 .I have stopped the hormone treatment and still take the zytega 250mg daily and added Thomas Labs Fish Bendazole,250mg pure Fenbendazole in each packet. 2 packets daily for 4 days and none for 3 days. 2400% or 180mg twice daily plus iron and an adult daily vitamin ,double calcium for bone healing, my last scan in January showed most lesions were gone or greatly reduced. I have blood test coming next week and will update any progress.

    1. Hi Eddy,
      I responded to your comment but did it as a reply to the thread instead of to you, so you may not have been notified. Anyhow, you will see my response and some questions I had for you if you look just below your posts on this blog thread.
      Thanks,
      Shanti

  40. Hi Eddy,
    I’m sorry to hear about the prostate cancer and I hope that you are tolerating the zytiga well. You probably know there was a small study indicating that 1/4th the dose of zytiga may be as effective as the full dose: https://www.sciencedaily.com/releases/2018/03/180328182506.htm. This small trial indicated that it may not be necessary to continue with 1st line ADT such as Lupron while on Zytiga: https://ascopubs.org/doi/abs/10.1200/JCO.2019.37.15_suppl.5046. I assume you made these treatment decisions to increase quality of life despite that they are not completely proven to be as effective as standard of care. I am wondering, did you notice less side effects with the 1/4th dose of zytiga and discontinuing the Lupron (or similar injection)? It would probably be a good idea to measure your testosterone levels on your next blood test. This will tell you how well your hormones are repressed with the current regimen. Also, if your PSA is up, it will tell you if it could be because your testosterone is not low enough or if it is because the zytiga is no longer effective and you need to switch meds.

  41. It is great that you had such a good response to the zytiga with a PSA of 0.2. Please let us know what your new results are when you get them. Are you taking any medications to help maintain bone density such as bisphosphonates or xgiva? Strong bones can help resist metastatic bone spread. In addition to calcium please also consider vitamin K2 (unless you are on Coumadin), vitamin D and magnesium, which are important for calcium absorption, metabolism and directing calcium into the bones and out of the arteries.
    There is some amazing information on this site for those with prostate cancer. I would use this time while PSA is controlled to plan out your next steps in your battle, should you need them. I would start with the Prostate Cancer page: https://www.cancertreatmentsresearch.com/category/cancer-types/ and the visitor’s story on prostate cancer: https://www.cancertreatmentsresearch.com/a-visitor-story-healing-from-stage-4-prostate-cancer-with-fasting-and-juicing/. I don’t want to overwhelm you with other links to great pages on this site, but please reach out with questions if you have them. I have just stared implementing a plan with my husband which you can view here: https://www.cancertreatmentsresearch.com/prostate-cancer/#comment-8625. We don’t have results to post yet, and implementation has been slow as his system is sensitive to a lot of medications, but we will keep everyone posted.

  42. If you don’t mind my asking, how many mets do you have? For people who have <8, Steriotactic Body Radiation Therapy with intention to cure is an option. What type of PET did you have?

    1. My full body scan in February was dark compared to the one in June of 2018, the comments by the Radiologist were the spinal metastasis were resolved and the rest were very small compared to the previous scan, which were every where but my fingers and toes. I was taking Xgeva for a year + along with fermigon once a month. Have stopped both but still take the Zytega @ 250mg per day with dinner , the scrip said 2x 500mg a day on an empty stomach but I must have read the same study on 1/4 the dose with a meal. I said no to radiation as it causes more harm than good.I had radiation treatment after the prostate was removed and it caused bladder cancer but that was removed 6 months ago and so far has not returned. we grow our own vegetables hydroponically indoors and also raise chickens (free range ) for the eggs. only using organic non gmo feeds.Our meat comes from local grass fed grass finished beef. At 72.5 so far so good.

  43. My full body scan in February was dark compared to the one in June of 2018, the comments by the Radiologist were the spinal metastasis were resolved and the rest were very small compared to the previous scan, which were every where but my fingers and toes. I was taking Xgeva for a year + along with fermigon once a month. Have stopped both but still take the Zytega @ 250mg per day with dinner , the scrip said 2x 500mg a day on an empty stomach but I must have read the same study on 1/4 the dose with a meal. I said no to radiation as it causes more harm than good.I had radiation treatment after the prostate was removed and it caused bladder cancer but that was removed 6 months ago and so far has not returned. we grow our own vegetables hydroponically indoors and also raise chickens (free range ) for the eggs. only using organic non gmo feeds.Our meat comes from local grass fed grass finished beef. At 72.5 so far so good.

    1. Hi Eddy,
      I glad you responded so well to treatment. Please keep us posted on how you are doing.
      Did you notice fewer side-effects/better quality of life when you switched to ¼ dose of zytiga from the full dose of zytiga + Fermigon + xgiva?
      Are you still taking prednisone or another corticosteroid along with the 250mg of zytiga or do you find it is not necessary?
      Thank you,
      Shanti

  44. Hi Daniel,

    I came across this article whilst researching Fenbendazole’s metabolic action on cancer pathways.

    Please accept my belated condolences on your wife’s departure from this earthly world. Your experiences resonate with what I had to go through with my only sister.

    My beloved wife currently has a massive breast tumor, which was initially shown as ‘suspicious’ cancer lump by oncologists (detected with and ultrasound scan), back in 2015. We refused a mammogram and biopsy and opted for a thermogram. The findings suggested Fybrocystic disease and no active pathology, then. After trying a holistic approach, we were able to shrink the lump to where it was not felt palpable any more. We stopped our natural protocol as it was becoming too expensive to continue.

    Then in 2018, the lump started growing again, coinciding with her perimenopausal symptoms. My wife was going through a lot of stress when her mother was ill and then when her mother died this year, the trauma was a shock to her physical and mental well being. Her tumor growth accelerated and when we had another thermography scan back in March 2019, it showed neovascularity and active pathology. We were recommended to start Angiostop (sea cucumber anti angiogenesis extract), Myomin (Aramotase inhibitor) and a few other things. Despite all or efforts, the recent scan has shown progressed neovascularity and invasion of axillary area. The tumor is massive. But, outwardly she seems well.

    Two weeks back, I had a CA 15-3 cancer marker test for her and it is off the scale at 600+. I also had a hormonal test and her Estradiol level is at 348 pmol/l – Prolactin at H 1104 mU/L (Normal levels 102 – 496).

    I believe her extremely high Estradiol levels is driving her cancer. She has now started on the Fenbendazole protocol, with a reliable source from the UK. We use a day version and night version taking a combined total of 520mg of active Fenbendazole in a day for the first ten days, then switch to pulsing days.

    Are there any metabolics I can add to her Fenbendazole protocol? I am considering the Cancer Oncology Care clinic here in London, can the Fenbendazole protocol be taken alongside their 4 drug combination without contraindication?

    I am also looking at alternative Estrogen inhibitors, any guidance would be appreciated.

    If anyone is using the Fenbendazole protocol, I have a unsealed bottle of 30 softgel (Gelatine caps) full spectrum CBD capsules at 25mg per capsule to give away free as I have a tincture source that works better for us. I will even pay for the postage. I will only mail to UK/Europe in countries, where it is legal.

    Thankyou,

    Waqar

    1. Dear Waqar,

      Thank you for your message and kind words. I am so sorry you had to go through similar experience with your only sister and now you have to deal with more challenges. I hope your dear wife will be good soon.

      There are so many things to say and it all depends on what are the next steps that you are considering, on your financial capabilities to go to clinics or even better have intravenous treatments at home, and on the type of treatment approach you will take, i.e. only alternative or alternative+conventional.

      For example, if you will go for chemo, it could make sense to use DCA prior to chemo https://www.cancertreatmentsresearch.com/dichloroacetate-dca-treatment-strategy/ or Salinomycin in combo with chemo https://www.cancertreatmentsresearch.com/salinomycin/ or 2DG metronomic in combo with chemo https://www.cancertreatmentsresearch.com/a-new-approach-to-improve-effectiveness-of-cancer-therapies-is-getting-ready-to-begin-human-trials/

      Many more things could be done in order to improve the effectiveness of chemo https://www.cancertreatmentsresearch.com/category/increasing-chemo-efectivness/ and https://www.cancertreatmentsresearch.com/if-chemotheraphy/
      Cholroquine given prior to surgery can reduce chance of metastasis (bullet point #8) https://www.cancertreatmentsresearch.com/tips-on-treatments-a-list-to-be-constantly-updated/
      Using anti inflammatory drugs prior to surgery will further reduce chance of relapse (bullet point #4) https://www.cancertreatmentsresearch.com/tips-on-treatments-a-list-to-be-constantly-updated/

      It is always best to surgically remove large tumors, but if I would decide to go fully on the alternative path, I would do my best to create a powerful treatment approach, addressing at least the following
      1. Have a suitable life style to reduce inflammation (via food, stress reduction, moderate exercise, sun exposure, good sleep)
      2. Built a strong cocktail of supplements and repurposed drugs (oral and/or intravenous) to address at least the following
      – Reduce chance for metastasis
      – Support kidney, live, immune system
      – Focus the attack on cancer on at least one weak point as intensive as possible

      Reducing chance for mets is working against inflammation. Celecobix may be the best here as it also addressees some prolactin related issues. But there are other mechanisms to address here to reduce the chance for mets, and Cimetidine is a good tool on this direction. Usually it is taken 800mg/day (400 morning and 400 evening). However, please read the warning regarding Cimetidine here https://www.cancertreatmentsresearch.com/tips-on-treatments-a-list-to-be-constantly-updated/ that is specifically relevant for those using hormonal treatments.

      Supporting kidney, live, immune system please see here https://www.cancertreatmentsresearch.com/cancer-treatments/ but best would be Astragalus, Milk Thistle, Probiotics, Coriolus

      To reduce stress (cortisol) Aswaganda and Omega 3 oils should help.

      Some of the weak points of cancer cells that can be addressed are the following:
      – Cholesterol – please read this https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/ and this post https://www.cancertreatmentsresearch.com/cholesterol-lowering-statin-drugs-to-fight-cancer/
      This should be specifically relevant to cancers that are strongly affected by hormones, such as breast cancer.
      – Ph – please read the following https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/
      – Metabolic – here the goal would be to address at the same time various energy production mechanisms, by inhibiting mitochondria and glycolysis. Here is a list of mitochondria inhibitors https://www.cancertreatmentsresearch.com/a-list-of-mitochondria-inhibitors/ and som glycolysis inhibitors I discussed on this website are addressed in the following posts:
      o https://www.cancertreatmentsresearch.com/high-dose-vitamin-c-cancer/
      o https://www.cancertreatmentsresearch.com/community/metabolic-inhibitors/combo-metformin-and-syrosingopine-looks-awesome/
      o https://www.cancertreatmentsresearch.com/glucose-absorption-inhibitors-to-inhibit-tumor-growth/
      o Fenbendazole would fit here
      – Other weak points that could be addressed and have been discussed here are
      o Reducing Antioxidants produced by tumors
      o Modulating ion dynamics https://www.cancertreatmentsresearch.com/category/ion-exchange-targets/
      o Influencing relevant hormones https://www.cancertreatmentsresearch.com/category/hormonal-target/ such as thyroid hormones https://www.cancertreatmentsresearch.com/induced-hypothiroidism-hypothyroxinemia/
      o Using angiogenesis inhibitors https://www.cancertreatmentsresearch.com/category/angiogenesis-inhibitors/
      o Using microtubule inhibitors such as Mebendazole or Fenbendazole

      Many of the drugs that can be used to address some of the weak points discussed above are addressing multiple weak points of tumors at the same time. For example, Metformin is also addressing the cholesterol production but also the metabolic weak point of cancers.

      In my view, any treatment strategy should address coherently at least one of the above weak points, e.g. metabolism.

      Example of other treatment approaches that could be added in parallel to a treatment strategy addressing some of the weak points of cancer is Silver https://www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/

      COC protocol you mention includes good anti-cancer drugs (Metformin, Doxy, Statin, Mbendazole). I would certainly start it as soon as possible. The first three are part of the anti-cholesterol strategy I mentioned above. Doxy and Metformin will also act against cancer stem cells. They will slow down tumor growth. But including what I discussed here https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/ and and here https://www.cancertreatmentsresearch.com/cholesterol-lowering-statin-drugs-to-fight-cancer/ will make it much stronger.

      Specifically, for Breast Cancer,
      – I would indeed use anti-cholesterol strategy
      – I would use one of Mebendazole https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/ or Fenbendazole since both are micro tubule inhibitors. Microtubule inhibitors are typically used in the treatment of breast cancer patients.
      – Baicalein is a very good natural extract against breast cancer – it can be bought from Chinese suppliers on Alibaba at 98% purity and mixed with oil, taken at about 400mg/day – I was in discussion with a prof from City of Hope institure in US considering to start a clinical trial on this due to its effectiveness against breast cancer. It can also be found as whole plant supplement but the extract (Baicalenin and not Baicalin) it’s best.
      – Omega 3 https://www.cancertreatmentsresearch.com/omega-3/ and this “Clinical Response of Metastatic Breast Cancer to Multi-targeted Therapeutic Approach: A Single Case Report” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3756422/
      – Please read the posts here https://www.cancertreatmentsresearch.com/community/breast-cancer/

      The fact that Prolactin level is very high, as you mention, is very important. Please read this article https://www.cancertreatmentsresearch.com/community/prostate-cancer/a-treatment-that-may-save-androgen-independent-prostate-cancer-patinets/#post-1094 it was on prostate cancer but I think it applies to breast cancer and other cancers where prolactin may drive the tumor growth. You may want to discuss with your oncologist the possibility of adding a drug to reduce prolactin. I will soon write an article on this subject, i.e. relevance of prolactin and its modulation to stop cancer growth.

      If you decide to go for COC protocol and want to improve its effectiveness with this approach https://www.cancertreatmentsresearch.com/cholesterol-lowering-statin-drugs-to-fight-cancer/ please let me know. If your oncologist supports, you with this please let me know and I will put him in contact with the Dr. scientist from UK who supported the other patient in the case report cited in my post. He can help with the treatment protocol.

      If you decide to go with Chemo and would like to implement this approach https://www.cancertreatmentsresearch.com/a-new-approach-to-improve-effectiveness-of-cancer-therapies-is-getting-ready-to-begin-human-trials/ to increase chance of effectiveness, I can put your oncologist or clinic in contact with the prof. scientist from US that can help with the treatment protocol.

      I hope this helps.

      Kind regards,
      Daniel

        1. Thanks Shanti! Now I am trying to catch up with my e-mails+continue research, but one day I should allocate time to write a post on this and pin it at the top of the homepage, to help the reader navigate through the content.

          1. D- have you considered compiling your info into a book, or even a series of booklets on approach or cancer type? I know that is a lot of work but could generate income for your other projects. I would want signed copies 🙂

            1. Thanks a lot Shanti! This question came just the right time, as I was investigating the mevalonate pathway in more details while understanding the major contribution of isoprenoids such as Lycopene in inhibiting HMGCR and helping Statins to do their job. And that took me yet again to the world of viruses, that are upregulating mevalonate pathway (which we also know is upregulated in most of the cancers). So it’s amazing how everything connects … from hormones to metabolims to cholesterol to pH to ions …. and so on … all are connected in a coherent manner in cancer. A coherence that is different compared to the normal cells but one that is similar to alterations known to be induced by parasites/viruses. And it is not only that the mechanisms that are similar, but also the drugs that affects parasites/viruses and cancer are similar. Here is an example where Metformin is suggested to be used as an antiviral drug https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5383345/
              When I see all this coherence, I think it would make sense to write it down in a book. But it’s hard to decide to go on this road. That is because writing a book takes a lot of time to write. And that would mean I may need to stop for a while answering people and writing here. But it’s clear I need to do something to generate a sustainable income. As you know, recently I stop my job to try and help the world as much as I can and I will give to myself an year to come up with a way that is sustainable, i.e. generate some financial income so that I can continue do that for long time. (for now I can support myself from my savings and unemployment benefit). Otherwise, I will need to go back to the industry and slow down with oncology research. At this moment, there are three major ways that may led to financial sustainability: starting the supplement company we discussed earlier; accessing European project funding; writing a book. Asking payment for coaching could be another way, but I want to avoid this as much as I can. You touch a sensitive point that is often in my mind, and this is why my longer response here, but if I write a book, the first I will certainly reserve it for you and collect signatures from all the friend on this website 🙂

          2. Hi D,
            Sorry for the late reply, we are traveling a bit at the moment. You have researched and learned so much that it must be amazing to connect all of the pieces into a larger understanding, and even more amazing that we live in an age where the information is there to allow us to do so! I was just thinking that, even 10 years ago, the landscape would have been completely different for the options available to my husband for treatment. I hope you don’t mind my brainstorming a bit, but so many people are in need of even basic information. So even starting out with smaller bite-sized booklets that are easier to write and may find a wider audience, could be a place to start. This could pave the road for the success of an eventual larger, more comprehensive book. For example, smaller books could be written on an approach for a specific cancer type, on managing cachexia, on 3BP and Sal, on another modality such as HCA/ALA/LDN, or on a specific mechanism of cancer metabolism. I know, still tons of work, maybe some of us could help out? You have given so much selflessly, I know I would be happy to help with research, editing, etc. I say that not ‘off-the-cuff’, but most sincerely.
            In Friendship,
            Shanti

            1. I like this idea, smaller (e)books on specific topics. That would probably reduce your workload later, as many questions you now receive would likely be answered in the books?
              Best Regards,
              Johan

            2. Dear Shanti and Johan,

              Thanks a lot for sharing your ideas and offer to help. I very much appreciate that. The idea of writing smaller books on cancer type is very good. Johan’s point regarding the many questions is also very good. Finding a way to reduce those is very important and it is my next goal, as I receive a lot of questions on my e-mail (many times questions that are already answered on the website). It takes even more time when people ask to help them develop the complete treatment strategy given their specific conditions, limitations, etc. Reducing the amount of questions I receive will help me switch from reactive (answering questions) to proactive approach (generating more value through content generation, collaborations, etc.). Although I do not like to use fees, I more and more tend to think that I should introduce a coaching fee for those who ask to perform research for their specific situations. That in turn should give me more time and financial sustainability to produce more value for all not just for a few.

              Kind regards,
              Daniel

          3. Regarding the paid consultations/coaching, I think your current model(free) is unsustainable. You’ve recently seen a bump in traffic from the search engines. With each increase in visitors, you will increasingly get buried in emails and questions! This community needs scientist like you for many years to come. In spite of many exciting new discoveries Standard of Care for many cancers, especially the solid tumors, hasn’t changed much over the last 40 years. A cancer-survivor, Glenn Sabin, charges $300 for a 75 minutes consultation. He’s not an MD, or Ph.D.!

            1. I would have to agree with johan on this point. Charging for a consultation, even if it is only $150 or so will give you some income, and most people can afford that. I have been amazed at how well your website is showing up on google searches now. When I first found it, it must have been just entering the perfect combo of words for it to show and I was thrilled by the find of this hidden treasure. Now, I see it listed when I am searching on many related topics!

            2. Thanks a lot dear friends for sharing your view on this, and for references. It really helps a lot, I will probably go on this route and see how I feel about it. I don’t want to make a life out of this, so I will see it as a short term approach towards the sustainability of my steps in oncology space. Also, if I ask a fee, I will make sure a part of that will go to research on some of the areas we will chose together here.

  45. Hello Everyone

    I am new to the forum and have read many of the posts. I have not seen references to the effectiveness, or the use, of fenbendazole towards metastaic basal cell. Is there any information out there in this area? I have already tried the Vismodegib route with short term success but the meds have stopped working.

    Thanks in advance

    Danny

    1. Dear Danny,

      On this website the contributors and myself discussed many treatment options that offer evidence-based hope even when the conventional treatment approaches stop working. Some can be used as stand alone, others can help increase or enable the effectiveness of conventional treatments. Because of the angle we take here to look at cancer (e.g. cell metabolism, hormone modulation, ion dynamics modulation, etc.) most of the treatments discussed here are relevant for most of the cancers, including basal cell. Here is an example of a treatment option discussed that is specifically relevant to basal cell https://www.cancertreatmentsresearch.com/eggplants-kill-cancer/
      Please take the time to read some posts on this website. Even if a post was written 3-years ago it will have the same relevance as if it was written today.

      I would also try Fenbendazole and I would also make sure I implement more of the treatment options in order to increase the chance of success.

      Kind regards,
      Daniel

      1. Daniel

        Thank you for the quick reply. I have previously looked at the referenced post. Most of the readily available information on BCC speak to topical treatments and applications. My questions on the Fenbendazole were because I had not seen it referenced or discussed in the forum, with respect to the BCC being metastasized to the bones, and didn’t realize that most of the treatments discussed were relevant to most types of the cancers. I am still learning here. Based on what I have been told by a few oncologists, I am an outlier with respect to the normal BCC behavior. Many thanks again

        Danny

      2. Hello Daniel
        You have commented on m use of several protocols for my medium risk MDS (2 missing chromosomes 12p & 20q). I started with 3 detox protocols as my urine showed very high mercury, lead and cadmium), I added lots of antioxidants E,A,K2,D, b12; b15, and lots of herbs and teas, than ozone; UVBI, and B17. Next I did a 12 week cycle of b17 at 3, 6 and finally 9gms 2x a week. I did fembendazole at tibbens protocol for 8 weeks. All this time 9 months now my blood as been stable in a range (wbc 1.1-1.9); RBC (3.0-3.6) and platelets (65-130).

        Today my alt doctor recommended a regiment I’ve never seen.
        Propranolol 20mg before meals 2x day
        Dipyridamole 50mg before meals 2x day
        Tagamet 400 mgs 2x days
        And a low dose statin (optional).

        Have you seen this? He says it’s for MDS; AMLand multiple myeloma.

        Any conflicts to the other things I’m doing? I had to stop the RSO at 3/4 gram of 750mg/gm THC as I could not function and am alone now.

        I will gladly make a contribution from my SS pension first days of sept when it arrives.
        Please continue your good work.
        Richard

        1. Dear Richard,

          The 4 drugs recommended by your alt doctor are indeed standing out in terms of relevance in the fight against cancer. I already wrote dedicated articles for Propranolol and Statins, and I often discussed Dipyridamole and Tagamet (Cimetidine). However, I do not know what strategy your alt doctor had in mind when he suggested these 4 to you. Maybe is good that you ask him for some references indicating why these drugs are his choice and not others?
          Cimetidine for example could make sense for AML: Complete remission in a patient with acute myelogenous leukemia treated with leukocyte alpha-interferon and cimetidine https://www.ncbi.nlm.nih.gov/pubmed/6587932
          Same for Statins: Statins induce lethal effects in acute myeloblastic leukemia [corrected] cells within 72 hours https://www.ncbi.nlm.nih.gov/pubmed/18231920
          Dipyridamole could help the effectiveness of statins as discussed here https://www.cancertreatmentsresearch.com/cholesterol-lowering-statin-drugs-to-fight-cancer/
          Here is a paper on AML combining Statin and Dipyridamole and concluding “This work provides strong evidence for the immediate evaluation of this novel combination of FDA-approved drugs in clinical trials.” https://www.ncbi.nlm.nih.gov/pubmed/24994712

          Kind regards,
          Daniel

          1. Thank you Daniel. I’ve read the links and honestly get a bit lost. First it’s not clear if the stem cells producing the aml ( white cell proliferation) are killed but I assume those are the reference to primary cells. As I have moderate risk MDS, with two missing chromosomes (12p and 20q) and not AML, thank god, would these approaches work? The ic50/90 or U937 mean nothing to me. I’m guessing until I meet with my alternative doctor he was doing the shotgun approach by combining all four drugs.
            Dosage isn’t clear either and my current body weight is 73 kilos down last 8 mo from 87.
            Platelets have responded to something we’re doing up to 120-130 from 50-60, but red still at 9.8 up a bit from 8.9; whites still at 1.3 to 1.5. Having tried so many things we can’t say what if anything has worked. So my thought was to stop all and try 2-4 of these drugs but dosage is the ?
            He’s proposing Tagamet 400 mg x 2 day, dipryidamole 50mg 2 per day, propranolol 20mg 2 per day and a statin dose unsure still.
            Beside vitamins and some antioxidants I’ve tried a herbal mix of 7 herbs last 3 weeks of cats xclaw 500mg x3 day, wormwood 430mg x3; Anamú 400mg x3; Curcumin 500mg x3; Pau d’arco 500mg x3; Chanca Piedra 500mg x 3; and Graviola 1000mg x3. So it’s even posible these herbs improved reds and platelets but unknown really.

            How can I verify doses bases on those articles and is my MDS likely to respond to an AML or MM treatment protocol. I know it’s conjecture but still I value your thoughts, it’s worth the risk if my almost 8 year old keeps his Dad.
            Thank you and blessings

          2. Hello Daniel
            I am having trouble getting dipyridamole as it’s been discontinued. Would warfin, Coumadin or cilostazol work the same with atrovastatin?

            Thank you. Please tell me how to donate with a credit card to your site or you?

            Richard

            1. The sire Shanti posted no longer has it. I’m checking local pharmacies here in Arizona, first 4 no luck. Thank you for trying.
              Richard

            2. Hi Richard,

              Same as Shanti, I used to buy many of my drugs from buy-pharma and everything went well always. Dipyridamol acts as a SREBP2 inhibition and that is why it helps to maintain effectiveness of Statins. This is an off-target activity compared to the main biological activity for which this drug was approved. So we cannot compare it with wafarin like drugs. There are other SREBP2 modulators such as tocotrienol and luteolin supplements, but my first choice if possible would probably be Dipyridamole.

              Thank you for considering a donation. Donations can be done with either papy pal or credit card via the Donate button located at the right side of the page (when using a desktop) or at the bottom of the page (when on mobile).

              Kind regards,
              Daniel

  46. I use translate, sorry. . Good morning to everyone. I already asked the question but I have a doubt, very complicated in France such a site as yours, beautiful! Can one at the same time as chemotherapy carboplatin/alimta + corticoide, can take hca and alpha lipoic acid??? I was told that corticoids suppressed immunity, and that lipoic acid boosts immunity…. Is that not contradictory? Thank you very much in advance

    1. Dear Barraz,

      Based on personal experience, I strongly advise to NOT combine alpha lipoic acid with chemotherapy. Alpha lipoic acid is a strong anti-oxidants and when used at the same time with chemo, it will stop the (pro-oxidant) action of chemotherapy.

      A drug that has similar action as alpha lipoic acid but can be combined with pro-oxidant therapies is DCA https://www.cancertreatmentsresearch.com/dichloroacetate-dca-treatment-strategy/

      Kind regards,
      Daniel

      1. Bonjour Daniel et un grand grand merci mon ami. Vous faites un travail remarquable ?

        Une dernière question avec mes excuses pour le dérangement

        Puis je prendre du souffre en même temps que la chimiotherapie ?

        Merci beaucoup d’avance

        1. Hi Barraz,

          I am not sure I understand correctly what “souffre en même” means. Could you please write in English or send me link to a product related to that? Thank you.

          Kind regards,
          Daniel

            1. Thank you for the translation. In my view, due to the anti-inflammatory, anti-bacterial, anti-viral, and anti-fungal action of DMSO and MSM, they should be fine and possibly help chemo.

              Kind regards,
              Daniel

  47. Lieber Daniel.
    Es gibt mehrere positive Untersuchungen zu Niclosamid(yomesan) bei HCC.
    Hast Du vielleicht eine Idee die Bioverfügbarkeit zu steigern. Die ist bei niclosamid sehr schlecht. Wäre es ein Versuch Wert es mit Cimetidin zu versuchen?
    Beste Grüsse
    Andre

    1. Dear Andre,

      Niclosamide is one of my favourites too but indeed the challenge its related to its poor absorption.

      Niclosamide is soluble in alcohol http://archives.who.int/eml/expcom/expcom14/niclosamide/safety_review_08feb05.pdf So one way would be to break the pill, convert in powder, mix with alcohol and drink that solution. This is expected to increase its absorption, but please note that as a result also chance of side effects increases. So I would start with a lower Niclosamide dose when taking with alcohol.

      Niclosamide is normally not water soluble but it seems that its solubility in water increases with pH https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777479/ So it may make sense to take Niclosamide 10-30 minutes after ingestion of Basentabs (alkaline tablets found as supplements online).

      For those who have access to a good chemist, included in this article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3777479/ is a procedure on how Niclosamide can be made water soluble.

      Kind regards,
      Daniel

      1. Lieber Daniel.
        Eine Frage noch wegen der löslichkeit und bioverfügbarkeit von Niclosamid. Halten Sie Dmso für eine Möglichkeit. Oder die Tabletten nach zerkleinern in nabic 8.4% Lösung auflösen und trinken?
        Die Tabletten sind Kautabletten.
        Beste Grüsse
        Andre

        1. Dear Andre,

          I do not expect that nabic 8.4% will help. On the other hand, DMSO will be better compared to alcohol in terms of solubility. The solubility of niclosamide in DMSO is approximately ~30 mg/ml. It will be however challenging to drink that much of DMSO as would take about 30ml DMSO for 1000g Niclosamide. Nevertheless, it doesn’t have to be made perfectly soluble. Another idea to increase bio-availability could be to mix the tablet (converted in powder) with oil.

          Kind regards,
          Daniel

          Kind regards,
          Daniel

  48. Lieber Daniel.
    Vielen Dank für die Information. Ich habe mich in Richtung Niclosamid orientiert, weil es absolut keine Lebertoxizität besitzt und ich wegen dem HCC vorsichtig sein muss wegen der Leberwerte.
    Glaubst du das Niclosamid ebenfalls wie Fenbendazole Synergien mit Vitamin E oder anderen Medikamenten besitzt? Das mit dem Alkohol werde ich mal versuchen.
    Vielen Dank
    Liebe Grüsse
    Andre

    1. Dear Andre,

      Niclosamide should work well with many, due to its multiple anti cancer effects. I would however not combine it with strong anti-oxidants. It is therefore debatable if Vit E should be used in combo with Niclosamide. (As a side note, just to stay on the safe side, because of the anti oxidant properties of Vit E, I would not used it during the chemo or radio therapy.)

      Kind regards,
      Daniel

      1. Hello Daniel, hello everyone. Once again, I need you. I am doing carboplatin/alimta chemo… Can I take coenzyme Q10? And second question, can I take aspirin 75mg? Thanks so much in advance

      2. Hallo lieber Daniel.
        Vielen vielen Dank erstmal für die Ihre wunderbaren Antworten. Ihre Arbeit ist wirklich fantastisch.
        Ich verstehe leider einen Zusammenhang nicht. Vitamin E ist ja ein starkes antioxidants. Das ist mir klar.
        Aber warum sollte es mit Niclosamide zusammen nicht funktionieren? In den Fenbendazole studien mit Ratten gab es nur Erfolge wenn Vitamin E zusätzlich gegeben wurde. Ansonsten nicht.
        Oder meinen Sie das es einen gravierenden Unterschied zwischen Febendazole und niclosamid gibt und nur fenbendazol mit Vitamin E zusammen funktioniert?
        Beste Grüsse
        Andre

        1. Dear Andre,

          This is a fair question. Many of these drugs and supplements act against cancer directly and indirectly via multiple mechanisms at the same time.

          The scientist who suggested to Joe to use Fenbendazole combined with Vit E did that based on the results from this paper https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2687140/ In this paper, the authors suggests that Fenbendazole action as microtubule inhibitors leads to hypoxia-inducible factor 1α (HIF) inhibition. The same paper suggests that anti oxidants such as Vitamin E were also shown to induce hypoxia-inducible factor 1α (HIF) inhibition. This is why they came up with the idea to combine Fenbendazole with Vit E.

          I just searched the literature, and Niclosamide is also known to inhibit hypoxia-inducible factor 1α (HIF). So from this point of view, we could think that is a good idea to combine Niclosamide with Vit E. However, Niclosamide was also found to increase pro-oxidant action of chemo, which could indicate that Niclosamide acts also via pro-oxidant anti cancer mechanism. This would be cancelled-out by the anti-oxidant action of Vit E.

          So as you can see, there are mechanisms suggesting that the combo of Niclosamide with Vit C works well, and other mechanisms suggesting that we should not combine the two.

          For me, the rule is that when there is doubt about a substance or a combo, I better avoid that and go for something else where there is no contradictory action. But nobody knows everything in this world, so in the end you can also check your feeling and go for what you feel is the best. The point is that if you feel you want to combine the two, there is also literature supporting that the combo could be better than one alone.

          I hope this helps a bit and doesn’t bring more confusion. Please let me know if it helps.

          Kind regards,
          Daniel

  49. Dear Daniel,

    Thank you for such a comprehensive reply, very helpful! I’m trying to keep my head above the water with all the information that I need to digest. We are not pursuing the conventional/standard therapy at this moment knowing what the biopsies, chemo and surgery did to my other family members.

    My wife started on the Fenbendazole treatment about 4 weeks ago combined with Vitamin E (Mixed Tocopherols & Tocotrienols) and full spectrum high dose CBD oil (12mg per drop). I contacted the COC in London, but they were unable to accept her on their protocol as she did not have a confirmed diagnosis and was not on any standard treatments.

    I am however, able to acquire the four repurposed drugs recommended by the COC, i.e. Metformin, Atorvastatin, Doxycycline and Mebendazole. Leave aside the Mebendazole as I will stick to the Fenbendazole. Would the Metformin, Atorvastatin, Doxycycline not contra-indict the efficacy of the Fenbendazole protocol? I have read conflicting views on forums some of the drugs should not be used with Vitamin E due to it’s strong anti-oxidant properties. I can discard the Vitamin E part of the protocol if there is any interference.

    I would like to cut off all cancer metabolic pathways whilst sticking to the Fenben protocol. I am considering the following additions: Low Dose Aspirin, Chloroquin, Cimetidine (she is not any hormone therapy, only natural Aromotase/Estrogen inhibitors such as DIM), Dipyridamole, Naltrexone (low-dose) and Celecoxib.

    If our pocket permits, we intend to use IV Vitamin C and Oncothermia treatments for the kill phase.

    Prior to this, I was using a Russian made Millimeter Wave Therapy Device called Cem Tech Spinor on my wife, whereby a unique oscillator crystal made of Gallium Arsenide records the exact electromagnetic frequencies of any diseased body organ within 60 seconds and replays back the frequencies to the same site or radial artery (‘like cures like’) to create pathogenic resonance destruction or healing. However, even though we knew it was hitting the tumor, it was causing extreme pain and swelling in the area and beyond, within 15 – 20 minutes of applying the resonance. I was also using a powerful frequency device with specific metabolic frequencies that is commonly found in most common cancers. Again, this caused considerable pain and soreness on the tumor for three – fours days.

    1. Dear Waqar,

      Interesting to hear that COC did not wanted to support … Cimetidine will increase the blood level of many drugs so it may be a good idea to first start with Cimetidine and than add to that every few days a new drug first at half the dose and a few days latter at target dose. Vitamin E is indeed debatable but it has its value as well, specifically as a part of the anti-cholesterol strategy. I would not use that in combo with chemo or radiation, but with other strategies it may make sense. When you have your strategy completed, you can share it here, explain what the goal is with each drug and the dose to be used, and I will think if there are other ideas to improve that.

      Interesting to hear about Cem Tech Spinor. I heaven’t heard of it so far.

      Kind regards,
      Daniel

  50. Hi Daniel,

    Thankyou Daniel,

    For the time being, I only managed to obtain Metformin, Doxycycline and Atorvastatin which my wife has added to her Fenbendazole protocol (Vitamin E includes Mixed Tocopherols and Tocotrienols + Curcumin + CBD oil). I will be ordering Berberine, Milk thistle, Quercetin and Baicalein.

    Her daily routine now is:

    Before breakfast – Aromahib (Aromatase inhibitor) Beta Glucans, Ceremonial Grade Matcha Green Tea and anti-cancer herb formulation by naturopath (includes Artemisia, Red Clover, Milk Thistle and others)

    After breakfast – 40mg Atorvastatin, 75mg Aspirin, Fenbendazole 130mg, Vitamin E (Tocopherols & Tocotrienols) 300mg, CBD oil at 84mg

    After lunch (two hours later on empty stomach) Doxycycline 100mg, Aromahib.

    Before bedtime Metformin 100mg, Fenbendazole 130mg, Vitamin E (Tocopherols & Tocotrienols), Melatonin 30mg, CBD @ 84mg and CQ10 with Omega 3 oil.

    The Fenbendazole started off at a dose of 130mg twice a day pulsed at 3 days on and 4 off. Then doubled the dosage for ten days straight without any adverse issues. Now doing 4 days on and 3 days off at double dose. I have a Fenbendazole formula that comes in both a day version and night version (with 30mg Melatonin). The formula also includes high dose Curcumin, Silimarin extract, Green tea extract, Ginger, MSM, Quercetin, and Piperine. So far she’s only been on the Fenbendazole protocol for about 5 weeks and her stabbing pains are less pronounced.

    The Cem Tech Spinor Device is indeed a remarkable device. Extensive clinical tests have been performed with the CEM TECH Millimeter wave instrument, for more than a decade, at leading Russian hospitals for various application settings and conditions. It’s little known in the West as much of the published research is in the Russian language. I have used it to stop cold viruses in their tracks, alleviate headaches and bruising. Currently use it to stimulate the immune system, lymphatic system and structure water for drinking. Treating the tumor with the device is painful and my wife does not like it as her pain threshold is very low. According to the inventors of this device it has the ability to record the information of any drug or medicine and replay it back to your body via your radial artery. This information can be stored on the oscillator for 5 years, but can be erased any time. I have not tried this method yet, though.

    https://spinor-m.com/how-it-works/

    Best wishes,

    Waqar

    1. Thanks Waqar. For Statin, it’s important to take in the morning and evening, at 12h distance due to the half time as discussed here https://www.cancertreatmentsresearch.com/cholesterol-lowering-statin-drugs-to-fight-cancer/ – here I also discussed another statin that may be even better. Also, the highest effectivness of Statin comes with the evening dose due to reasons discussed here https://www.cancertreatmentsresearch.com/chronotherapy-taking-the-treatment-at-the-right-time-has-major-impact-on-the-outcome/
      Years ago, I used to buy many of my drugs here https://www.buy-pharma.md/
      I am glad to hear there is less pain!
      Thanks for the details on Chem Tech Spinor

      Kind regards,
      Daniel

      1. Thankyou Daniel for the links, very helpful especially the pharma source.

        I actually researched on Circadian Rhythms about 25 years ago and had primitive software on my now defunct Packard Bell PC that generated my physical, mental and emotional peaks and lows throughout the month. Oh, how time flies! Japanese pilots used them to predict which days they would hit double or triple critical junctures, whereby their physical, emotional and mental faculties would be at the lowest ebb, hence, they would reschedule their flying duties to minimize human errors.

        Pitavastatin may raise Calcium blood levels in my wife who has hypercalcemia (very high level of calcium in her blood), so may need to avoid this. I’m going to stick with Atorvastatin, but start off slowly with one 40mg at evening. Then, in about a week’s time include a morning dose.

        Metformin can be taken in evening with Fenbendazole?

        Kind Regards,

        Waqar

        1. Hi Waqar,

          You are very welcome.Circadian Rhythms are a important part of our life that we often forget to consider.
          I would spread Metformin over the day, e.g. 500 in the morning and 500 in the eve.

          Kind regards,
          Daniel

  51. Hi Daniel,
    Thank you very much for the info. I am 54 years old 63 kg. I had a lobular carcinoma (breast cancer) Estrogen positive, her negative in 2013. It was stage1-2 (2.2 mm lump)
    I had a mastectomy and Tamoxifen for 3 years. I denied a chemotherapy. I was supposed to take tamoxifen for 5-10 years, but I quit taken it in 3 years, because I thought I am completely healthy. Unfortunately, I had a recurrence in 5 years.
    Last year (2018 December) (in 5 years) I had a local recurrence (the same spot, where it was 5 years ago) It was 5 mm lump. I had lumpectomy. Now i take letrozole (femara) and a lot of supplements. What would you suggest me to take : fenbendazole or mebendazole? What doze would you recommend me to take and how long? I also use izatizon.
    Thank you very much and blessings to you and your family

    1. Dear Sky,

      both of them have a low toxicity. Dose of more than 1g/day of Mebendazole has been given to children for many months https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/
      For Fenbendazole I would follow the protocol of Joe, and for Mebendazole I would take 200mg/day in the evening, with food to increase absorption https://www.cancertreatmentsresearch.com/chronotherapy-taking-the-treatment-at-the-right-time-has-major-impact-on-the-outcome/#comment-7325

      Kind regards,
      Daniel

  52. Daniel,
    I also wanted to add that immediately after the lumpectomy, I had radiotherapy for 30 days. And my white blood cells fell to 2.9. Now I’m trying to improve them, to raise them. Should I wait until my white blood count improves and then take fenbendazole? Or can I take it now? Thank you very much, Daniel for your work and your personal time that you spend on us

    1. Dear Sky,

      Thank you for the kind words. It’s my pleasure to help as much as I can and you are very welcome. It’s true I have challenges with time. I would probably wait a little with Fenbendazole and Mebendazole to have a better white blood profile. During this time I would use Metformin to slow down possible cancer cells. I would also use anti inflammatory medication such as Celecoxib but also natural ones such as Omega 3 in higher dose. To improve radiotheraphy, I would consider this strategy https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/

      Kind regards,
      Daniel

  53. Hello everyone. Sorry for my bad English…. I just received from the root of astragalus. I’m on chemotherapy ‘carboplatin-alimta’ Question: can I drink astragal root or is that the opposite? Thank you in advance for your informed answers ??

    1. Sorry to ask so many questions! Maybe it’s easy for some, but I’m not a scientist… Thank you from the bottom of my heart for your kindness and understanding

      1. It’s no problem Barraz. For me and the friends here it’s a pleasure to answer with our view, and even more when you ask very clear and to the point questions. Of course, nobody knows everything, but we do our best to learn and help.

    2. Dear Barraz, although Astragalus has antioxidant properties, on my scale it’s a moderate antioxidant. Given that is offers good protection for the organs and when taken orally and in moderate dose should not have strong antioxidant actions, I would continue to take it. However, I would stop it ~2 days before chemo day and ~4 days after chemo. That is what I would do.

      Kind regards,
      Daniel

            1. I also want to thank Shanti. You and Daniel reassure a lot of people. May God restore it to you and protect you both… And heal us all

  54. I also did some research on plants, and I started today a mixture of these plants below. I think it’s a very good herbal tea, which can help ??

    Milk Quail/ Blessed Thistle/ Desmodium/ Oregano/ Sorrel/ Elderberry/ Red Clover

      1. Hello Daniel, I hope you are well. I started tea 2/3 days ago.

        I will keep you informed as soon as possible.

        Thank you for your interest in my herbal tea.

        May God preserve and protect you ?

  55. Hello Daniel and Johan
    I am getting emails saying I have a reply but the link doesn’t take me to the reply or even my prior post. Johan mentioned an article on Maitake beta Glucan I’ve been using beta 1,3D Glucan at 1500mg to 2000 mg daily for 6 months but no idea what it’s made from and find no source of Maitake beta Glucan or is it two things I need to use?

    Perhaps I should post under Johan’s reply but I spent 20 min and can’t find it here?

    Thx
    Richard

    1. Hi Richard,

      Johan’s reply is here https://www.cancertreatmentsresearch.com/fenbendazole/#comment-8916

      Sorry for that – You can not post a reply to his comment because there is a limit for how many time people can reply to each other in a single thread. This prevents threads becoming too long and as a results becoming unreadable, since every reply is shifted to the right side a little. It’s just a technical choice implemented within WorldPress, which I prefer to keep active. Thanks for understanding.

      Kind regards,
      Daniel

  56. Hi Richard, it looks like there’s a limit on the # of replies per thread.

    The study mentions the use of a Maitake extract (containing beta-glucans with a 1,6-glucan main chain and 1,3-branches) at 6mg/kg/daily. The 1,3D beta-glucans you’re taking could be from yeast or grains, I’d check on that.

    Fungi Perfecti is a good source of quality maitake supplements, another good one is Maitake Gold 404.
    https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202470/

    Best Regards
    Johan

    1. Hi Raymond,

      I discussed this subject here sometime in 2015 https://www.cancertreatmentsresearch.com/some-of-the-most-effective-treatments-in-my-view/#comment-889

      Overall, based on discussions with various people during the past years, I am left with mixed feelings regarding dr. Lentz and his approach, probably because of the amount of money he is asking. Here are some quotes from a private discussion I had with a Dr. on this subjects including some info that may be relevant:

      “Also, there is a Dr Rigdon Lentz in Prien, Germany who developed a special immunopheresis instrument to filter a blocking agent out of the blood. It works quite well. Sounds very similar to treatment concept in this article. Very expensive per treatment. I met him about 6 years ago. Some of his patients went back in 2 – 3 years as they needed treated again for the recurrence of their cancer.

      I knew one patient who had a brain tumor on whom Dr. Lentz’s treatment did not work. He had many side effects. He was a holistic doctor & knew about diet, etc.”

      “I think Lentz treatment was much more…perhaps $200 – 250 K per group of treatments. But he did turn around stage IV cancers many times. He used antibodies made in rabbits as the filter.”

      And here is a quote from a patient with whom I was discussing on this subject:

      “One of the first doctors I contacted after receiving my mothers diagnosis was actually Dr. Lentz. I find immunopheresys very interesting, and Dr. Lentz seemed to be a very kind doctor. But he told me that they did not have any experience with small cell lung cancer, and considering the costs for this treatment it would be a risk to take. But it really is a promising treatment for many types of cancer.”

      Note that this is relatively old info (from 2016) so prices and outcomes may be different at this point. I hope this helps a little.

      If you discuss with dr. Lentz and have new info, please let me know.

      Kind regards,
      Daniel

  57. Hello Daniel
    Rather than comment on my prior posts I have a few questions about these two protocols.

    My blood from Friday shows a big drop in RBC from 9.8 to 7.8, platelets from 135 to 90. Wbc still at 1.2-1.3.
    Do you think the statin and dipyridamole is risky with my current blood?

    Would propranolol and Cimetidine be a better choice? I could not locate any papers on this combo or your prior posts.
    We are trying to determine the cause for sudden drops. I did stop RSO and B-17.

    Thx
    Richard

    1. Dear Richard,

      Although we had a few discussions here, it’s not completely clear to me your case. In order to help with some more ideas, please send me a summary containing the following info:

      – age, location, time of diagnostic, conventional and alternative treatments performed so far (intravenous, oral, etc.), tumor evolution following these treatments, tumor size and location(s) now, next treatments options your oncologist and alternative doctor is suggesting, next treatment options you are considering, any other info that you think it may be relevant related to your current status.

      I know some of the questions above you already answered in previous comments. In this way I will have a more clear picture on where you are. If you prefer to send me the overview on the e-mail that is also fine. Otherwise, you can create your own topic on the Forum https://www.cancertreatmentsresearch.com/community/

      I am very busy at this moment, but I will do my best to answer fast.

      Kind regards,
      Daniel

  58. Greetings Daniel,

    I came across the news about Fenbendazol through a friend, since I have been trying to help my mother who suffers from CML Chronic Myeloid Leukemia and her current WBC count is 140000, she is not on quemotherapy anymore and her BCR/ABL1 is 78.
    At the moment she is on high doses of Boswell4, Ultracur Curcumin and I have been suggested a canine dewormer known as Panacur C + high doses of Vitamin E. I found hope when I came across this article. Her current hemoglobine is 9.6 and her weight is 103 lbs. It is very difficult to find all these products in Spain and I have been importing them from the USA. Just waiting for my Safe-guard dewormer suspension for beef, dairy cattle and goats 1000ml (that has fenbendazole) and would really appreciate your help on how to dose under her current circumstances. Thank you, and God Bless you.

    1. Dear Kantu,

      I am sorry to hear about your mom. Is she off chemo because there are no treatments available for her anymore? If that is the case, you will find on this website many treatment options that have good chance to add value.

      The easiest one to implement is the COC protocol https://www.cancertreatmentsresearch.com/drug-cocktail-that-could-double-the-average-survival-time/
      In the COC protocol you can consider adding Fenbendazole instead of Mebendazole. Regarding the dose of Fenbendazole, I understand your mom has about 47kg. I think even for this weight I would keep the same dose that Joe used and is discussed in the article I wrote on this page. The dose is relatively low anyway compared to doses that are use for a similar drug (Mebendazole).

      Another that can be very fast added is this one https://www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/
      Many more approaches that can be considered are discussed in this post https://www.cancertreatmentsresearch.com/fenbendazole/#comment-8822

      If you have questions please let me know.

      Good Bless you too,
      Daniel

  59. What is the difference betweetster fenbendazol and anastrazol? The latter is an aromatase inhibitor targetten to reduce estrogen, but as it is also a Medicine in the azole, fungi killing group, is there similarity or are they completere different?
    Also is it possible to mail you directory?

    1. Dear Linda,

      They are part of the same group, Azoles that also include e.g. Mebendazole, Albendazole, Itraconazole, Ketokonazole, etc that also have anti cancer effects. Even if the sound the same, they have different biological effects. However, your questions is very good. So I did some research and it seems that Fenbendazole can have some aromatase inhibition action, but that is relatively low activity compared to Anastrazole
      Ref.1: https://pdfs.semanticscholar.org/1e34/363437187713dc6fc51aade918d9a968277c.pdf
      Ref.2: https://www.sciencedirect.com/science/article/pii/0022473188902075
      Ref.3: some azole drugs may disrupt estrogen production https://www.tandfonline.com/doi/abs/10.1081/ERC-120015045

      Regarding the direct contact, please read the following https://www.cancertreatmentsresearch.com/contact/

      Kind regards,
      Daniel

  60. HI Daniel.
    Above all, thanks for your information. What I want to ask is that can FB be used together with chemotherapy(especially FOLFIRINOX for Pancreatic cancer)? I’m worried whether the combined use of those two biochemical drugs induce worse output.. Thanks in advance for your reply.

    1. Dear SWH,

      You are very welcome. My view is that 3 days before chemo-day all drugs and supplements that may slow down cancer should be halted, including Fenbendazole. That is what I would do with Fenbendazole too. Otherwise, I would use Fenbendazole and other drugs that possibly can help chemo and improve the chance for a successful outcome. As a side note, it’s a good idea to drink some coffee before chemo, to possibly improve the micro-circulation https://www.ncbi.nlm.nih.gov/pubmed/25727960 and with that increase the chance for chemo to get to the tumor.

      Kind regards,
      Daniel

  61. Hello,

    I am writing on behalf of my brother (47 yrs) who has recently been diagnosed (12 July) with Adenocarcinoma in the duodenum. His CA-19-9 marker levels showed 3770. His PET CT scans revealed the tumour to be in D2 and part of the right kidney.

    The doctors planned for Whipples but ended doing gastrojejunostomy on 01 August 2019 as they found that the tumour in D2 & D3 was infiltrating the upper pole of the right kidney and transverse colon.

    We started him on Cannabis Oil from 20 August 2019. We also started Mistletoe Helixor injections after a week. Had to stop the Mistletoe as his cellulitis reoccurred and he had to start antibiotics. He had developed Cellulitis in his left leg in 2012 due to an insect bite. We are continuing the Mistletoe after the antibiotic course. Its been about 6 injections till now.

    We tested his CA 19-9 levels after surgery and before starting anything (19 Aug) which was 3469. Again when tested on 07 Sept, it was 10698.5.

    We have also started Wheat grass since 2 days.

    Will be doing scans prescribed by the onco before going for Chemo this week. Did not want to go for any chemo but these levels really scare us now.

    Can we use Fenbendazole with supplements while using the others that are already ongoing? Any inputs will be highly appreciated.

    1. Dear varalakshmibogale,

      In my view, Fenbendazole can be used with the others you mentioned. But if your brother starts chemo, ~3 days before chemo is good to stop Fenbendazole and other drugs and supplements that may slow down cancer cells. After that they can be restarted, immediately with or after chemo. After antibiotics I would expect CA19-9 to be lower. Is that the case?
      Please look through the articles in this website. You will find more treatment options you can add next to the treatment options from the oncologist to improve chance of success.

      Kind regards,
      Daniel

  62. Hello, My white German shepherd has osteosarcoma in her leg and I’ve been giving her the Fenbendazole, vitamin E, Curcumin, and CBD oil for 2 days now. I was wondering will this work on primary bone cancer and if so would the bone eventually grow back if the tumor shrinks ?

    1. Hello Jmcsott,

      I am sorry that I do not have feedback. My dog was just diagnosed with lymphoma and today is day one I had the opportunity to read this blog.
      Could you please share how you are giving your dog the FB, dosage, protocol, combination with the Vitamin E, Curcmin and CBD?

      Thank you so much in advance,

      Melina

  63. hi Daniel
    My name is Jamie. My mom is 70 years old with stage 4 breast cancer. She had a left mastectomy but after 2years it spread to her left neck area and formed a large heterogeneous mass. The lesion is ER positive but PR and HER-2 negative. she’s been on chemo and radiation for the last 2 years but not much success on getting rid of the tumor but on the positive side it did not spread to other areas. however all the standard cancer treatment has took a toll on her health. She has lost a lot of weight and no energy .
    We came across Joe’s story and found your site. It blew my mind away with all the informations… thank you for all the informative informations.
    we want to start taking fenbendazole and wanted to seek your expertise.

    1. she stopped with her chemo treatments inorder to start taking the Fenbendazole. but can she still take the IV vitamin C. she’s been on IV vitamin C for the 1yr, x2 times a week.

    2. how to take Fenbendazole. should we mix the powder in water? in food?

    3. doctors found a small lump in my dad’s prostate. doctor said its not serious and that they want to keep a eye on it. my dad also wants to take Fenbendazole. should he take it? if so should it be same dosage 220mg or less?

    thank you in advance for all your help.

    best regards Jamie

    1. Dear Jamie,

      Thank you for your comment.
      1. If your mom stopped with chemo, you may want to include some more supplements and repurpused drugs. At least anti inflammatory drugs and supplements could help. I don’t see any reason why your mom should stop IV Vit C while on Fenbendazole
      2. You can mix the granules with water or with some food that has some moisture. Here is a Facebook group with people taking Fenbendazole and sharing experience https://www.facebook.com/groups/429159131252194/
      3. I actually think everyone (whether cancer patient or not) should do at least one anti parasitic cycle every year. Fenbendazole could be one option for that. Niclosamie and/or Mebendazole are options too. As a preventive action, your dad could take also supplements discussed here https://www.cancertreatmentsresearch.com/prostate-cancer/ or here https://www.cancertreatmentsresearch.com/community/prostate-cancer/

      Kind regards,
      Daniel

      1. hi Daniel
        thank you for your valuable feedback. My family greatly appreciate all the information you provide.
        this is what we came up with for my mom’s home cocktail …
        breakfast: veggie juice with barley grass powder and spirulina
        110mg of fenbendazole
        670mg vitamin E (d-altha tocopherol…)
        lunch: vitamin B complex+ vitamin D
        dinner: 110g of fenbendazole + vitamin A 10,000iu

        she gets IV vitamin c twice a week and also takes vitamin c powder every day.

        We will get the recommended supplements for my dad as suggested as well.

        Thank you so much for your help. *^ ^*
        best regards Jamie

        p.s. for all the cancer fighting warriors and their families, with you best of luck and God bless. =)

          1. hi Shanti
            thank you so much for your valuable feedback.
            yes we are in US. we purchased a different brand but will place an order for the same vita E which Joe took.
            thank you again.
            b regards jamie

  64. hi Daniel
    We need your expertise again.
    My mother’s recent tests showed that her chemo is actually working on her left neck mass. However they found a microlobulated mass in her left lung. Her doctor is currently giving her:
    paclitaxel protein-bound 175mg 1per week
    filgrastim 300mg 1per week
    famotide 20mg 1per week 
    Dexamethasone 4mg 1per week 
    Ondansetron 16mg 1per week
    ascorbic acid 75mg x2 per week
    Also due to the treatments her glucose level has increased and her creatine is low and her BUN/creatine ration is high.

    Our doctor is not keen to unconventional treatments so we couldn’t tell the doctor about taking the Fenbendazole. We are afraid if he knew he might not want to keep my mom as his patient. 

    I was wondering if its possible/ safe for her to keep her chemo treatments with fendendazole+ vita E+ vita A+ vitamin B complex…
    We want to make sure there aren’t any negative interactions between all the drugs she’s taking. Also we are afraid its too much for her liver and kidney to handle all the drugs whats coming into her system. 

    I greatly appreciate your thought on this matter. 
    thank you again for your help. jamie

    1. Dear Jamie,

      I do not expect and I am not aware of a major interaction between Paclitaxel and Fenbendazole. I also do not expect Fenbendazole adds too much toxicity. I am not to much in flavor of the vitamin B complex, unless that is taken to address a major need in that area. In my view these are not too much drugs to have major worries regarding liver and kidney toxicity (of-course with the exception of chemo that always has some impact on liver and kidney). But if your mom feels there is too much toxicity coming from Fenbendazole you should stop it – or you could at least add Milk thistle and Astragalus supplements. Juicing in between chemo sessions may also help.

      If you are not happy with the chemo effectiveness, please read through the website. I often discussed approaches to possibly increase chemo effectiveness, via the inhibition of various resistance mechanisms. If there is a specific question on this please let me know.

      Kind regards,
      Daniel

      Kind regards,
      Daniel

  65. Hi Daniel
    Thank you so much for your response to my inquiry.
    My family appreciates all the valuable information you provide us.
    Thank you again *^ ^*
    Best regards
    Jamie

  66. Hi Daniel and all!

    Just happen to see a very encory pist in facebook regarding the use of febendasole with great success in GBM:
    https://m.facebook.com/groups/716535231750982?view=permalink&id=3043111989093283

    The q&a in this post add more details. What interesting is from what I understand, they used higher dosage of febendasole 5days/week (2 days off).

    Will appreciate your comments on their strategy.
    Also,
    1. What (if any) is the main difference between febendazole and mebendazole? Should we consider to change to fbz or combine both?

    Finally, could you please review this combined fbz product+curcumin+ melatonin+…? What is your opinion:
    https://werone.co/eng/product/biohackit-fenbencur-febendazole-herbal-anti-tumor-formula-capsules?fbclid=IwAR3jUnGcIhPGsDkvthFllnraMYSTh4-Izs5W8ERAOnGoyRVF5tngZzLX820

    Many many thanks!!!
    Best regards,
    Nissim

  67. My husband has glioblastoma, and we are thinking about using Fenbendazole (we already have it). The Fenbendazole protocol includes taking Vitamin E. I just saw a few articles which show a link between vitamin E levels in the blood and the increased risk of brain tumours. https://www.nutraingredients.com/Article/2016/05/24/Link-between-vitamin-E-brain-tumours-found-in-metabolite-study and https://www.sciencedaily.com/releases/2016/05/160519120738.htm
    Now we put Vitamin E on hold. Not sure if taking Vitamin E with Fenbendazole is necessary or it can be omitted to be on a safe side. Daniel, what are your thoughts on this?

    1. Dear Olga,

      The use of Vit E in cancer patients is debatable, as you mention and as it has been discussed by active contributors on this website. And I agree with that. As a result, I would only use it where it is specifically known to added value, such as discussed in my post on anti cholesterol strategy https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/ If you do not have a good feeling about it it’s best to stop. Fenbendazole can have anti cancer activity without Vit E. However, it may be challenging for Fenbendazole to get it at high enough dose to the brain. Try to increase it’s absorption by taking it with e.g. fats.

      Kind regards,
      Daniel

          1. Hi Daniel,
            I have many contacted all the alternative clinics in Switzerland with regard to 2-DG – no luck. Following your advice, I have contacted the clinics in Germany, Spain and Romania. Neither Dr. Hüseyin Sahinbas nor Dr. Kilarski do 2-DG. I didn’t receive an answer from a clinic in Romania. Among all of them, only two clinics work with 2-DG:

            1. the clinic in Spain offer oncothermia together with 2-DG.
            2. https://www.erweiterte-medizin.de/ in Frankfurt (Germany) offer 2-DG as well as hyperthermia perfusion (heating the blood so that the body will be heated till 42 centigrade degrees. This will damage the weakened cells by the 2-DG). They also do pulsing magnet fields (PAPIMI) and regional hyperthermia directly to the brain.

            I am in contact with both of them. Hopefully, it will work out very soon. Being in Switzerland and receiving Avastin every 2 weeks it’s not easy to go abroad for 2-DG.

            Thank you for your help,
            Olga

            1. Hi Olga,

              Thanks for the details. If you want me to check with other clinics, please let me know. I can get you in contact with them.

              Kind regards,
              Daniel

            2. Sorry to hear your husband’s illness.
              You do very well to build the therapy step by step. Adding fdz is a good option.
              Unfortunately, the clinic you mention in Granada does not offer 2dg therapy.
              It’s Spain is out of legislation and this is a problem.
              On the other hand they are a very good option in Oncotermia.

              kind regards

  68. Hi Daniel,
    I am curious if you could tell whether there will be any benefits of Fenbendazole on people with Lupus? I was diagnosed with rheumatoid arthritis and sjogren and mild lupus and the doctors gave me a final diagnosis which was a mixed connective tissue disease. I would like to try taking Fenbendazole if it will benefit my illness. Could you please advise?
    Thanks
    Ps.
    I’m in Adelaide, where could i get the Fenbendazole? Any vet?

    1. Hi Adel,

      For autoimmune disease I would:
      – consider anti parasite drugs and or supplements in short cycles, e.g. one week. Fenbendazole could be one cycle, Niclosamide another.
      – consider metabolic inhibitors https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6572063/ and Fenbendazole could be one (GLUT inhibitor), but not so strong. There are many metabolic inhibitors discussed on this website and I will soon publish an article including more
      – consider specifically MCT1 inhibitors, such as Quercetin and Omega 3
      As Shanti said, LDN is another relevant option.

      Kind regards,
      Daniel

  69. Hi Adel,
    Have you considered Low Dose Naltrexone? The research is much more abundant and compelling. Fenbendazole has very limited human studies and its mechanism as relates to cancer doesn’t apply to autoimmune. If someone had parasites and their immune system was overreacting for that reason, it may be more appropriate. Here is some of the research in animals on fenbendazole and autoimmune: https://www.ncbi.nlm.nih.gov/pubmed/?term=fenbendazole+%5Bti%5D+autoimmune.
    Here are some links to LDN and its use in autoimmune disease:
    https://www.ncbi.nlm.nih.gov/pubmed/29885638
    https://kresserinstitute.com/low-dose-naltrexone-promising-drug-hard-treat-conditions/
    https://www.amymyersmd.com/2017/05/low-dose-naltrexone/
    Best,
    Shanti

    1. Hi Shanti,

      I heard about LDN but didn’t know much about it. I will read through the article you sent, thank you so much for that.
      Do you think my rheumy would give a prescription for the LDN though? My Rheumy never told me about that stuff….
      I have an appointment in a week so I will discuss with her.

      Kind regards
      Adel

      1. Hi Adel-
        LDN is an off label use of a medication used in higher doses for opiate withdrawal. Docs are often not familiar, although here in the states its use is more and more common. I have purchased it before here: https://www.buyldn.com/naltrexlow. I am not sure if you would have trouble getting it through customs in Australia, in the US, no problem. If your doc is willing to prescribe it, you can get it from a compounding pharmacy, or you can get the standard 50mg and dilute it as described here: https://www.rivernewsdesk.com/2011/08/24/preparing-low-dose-naltrexone-at-home/. The low dose of naltrexone is thought to work by causing your body to make more endorphins (its own opioids) which helps with the discomforts of autoimmune disease as well as positively modulating the immune system.
        Best, Shanti

  70. Hello.
    I’ll try and ask this question here:

    Do you have any information regarding possible allergens in Panacur C? Gluten etc? Considering it’s not made specifically for human consumption, is there a way to find out the inactive ingredients? Also do you think it could contain other things not listed?

    And second question: How do you think Fenben will work for non-cancerous tumours? Endocrine tumors or even neuroendocrine?

    Happy to have found this site, best regards.

    1. Hi Ny Hope,

      To my knowledge, the list of excipients in Panacur is here:
      https://www.hpra.ie/img/uploaded/swedocuments/Licence_VPA10996-113-001_24112017184821.pdf
      https://www.wormers-direct.co.uk/panacur-equine-granules-contraindications-dosage-admistration-z-135.html?chapter=0
      It includes Lactose monohydrate, Povidone 2500, Maize starch.

      For neuroendocrine tumors, please see the links from this comment.
      (Fenbendazole has a low toxicity so it can be tried anyway, but I would not rely on its effectiveness only, and would make sure this is just a tool within a more extended treatment strategy.)

      Kind regards,
      Daniel

  71. Hi.
    My first comment here. Amazing blog. Thanks to Daniel for his dedication.
    Question. My dear wife has stage IV BC with mets on bone and liver. We want to start the panacur protocol but are unsure about the stress on her liver, would panacur have negative effects on her liver? She’s been through 3 lines of chemo to no avail and her prognosis right now is dismal, her BC was originally estrogen+ but the liver mets are TNBC. Please help.

    1. Hi Mario,

      I am so sorry to hear about your dear wife. I am not sure what is the condition of her liver but in general these kind of drugs (like Fenbendazole and Mebendazole), at normal dose, have a minimal toxicity on the liver.

      If you like and have time, you can also create a topic on the Forum https://www.cancertreatmentsresearch.com/community/ with your wife’s case, and the kind contributors on this website and myself can help with generating ideas on treatment options. Or you can send the case to me (by e-mail) and I can publish it as a case on the main page as I did for a few people in the past (this option may get more attention). If you do that, it would be best to create a short summary of the tumor evolution, connected with the condition of your dear wife connected with the treatments performed (conventional and alternative, oral and IV). Also add what is now done and what is proposed by the medical doctors as next steps in terms of treatments.

      Kind regards,
      Daniel

  72. I’d like to point out that the main group discussing fenbendazole use for cancer is actually Joe Tippens’s Facebook group, “mycancerstory.rocks”. There is also another one for fenbendazole used for cancer in pets, called “mycancerstory.rocks for pets”. It is recommended to read Joe Tippens’s complete blog post on fenbendazole prior to joining the Facebook group, to gain a level of knowledge on the subject before joining. The blog post also contains the password you will be asked for when joining the FB group.

  73. Hello. In the article you posed the question: ” “could it be that the origins of this synergy comes from the possible glutathione depletion previously observed to be related to Fenbenzadole?” I’m no scientist, just Chicken Lady, but love this stuff. I checked your reference and I’m going to venture to answer your question! The reference states that there was a 63% mortality rate in mice who were treated with Acetimetiphene ( sp?) along with the Fenbenzadole. So, therefore, I’m going to guess that the glutathion depletion comes from the combining, not from Fenben alone. I do know that incidence of cancer is largely reduced when Glutathion remains high in the body. I supplement with NAC and Alpha Lipoic acid for that reason. I became concerned when you asked the question because I always thought I wanted to keep Glutathion levels high to prevent a reoccurrence and worried fenben would decrease it. . So…long story short…it appears i need not worry because it’s only with Acedimetaphine that the glut is depleted…actually causing death for many poor mice!

    1. Dear Marylen,

      Thank you for your comment. According to the paper, Fenbendazole alone may be able to suppress GSH (and as a result exacerbates the hepatotoxicity of acetaminophen). Here are statements from the paper:

      ” Whereas by 12 h post-acetaminophen, GSH levels were at control levels in mice fed the standard diet, they remained suppressed in mice fed the fenbendazole-containing diet. GSH levels were also suppressed in control mice fed fenbendazole. Fenbendazole is known to undergo sulfoxidation to generate oxfendazole, which can act as a carbamylating agent for reduced GSH (Schuphan et al., 1981; Short et al., 1988). This leads to the formation of oxfendazole GSH conjugates, effectively depleting GSH from the tissue (Schuphan et al., 1981). Oxfendazole and fenbendazole have also been reported to upregulate glutathione peroxidase and glutathione-S-transferase in rats (Dewa et al., 2007); this may also contribute to persistent GSH depletion.

      In summary, the present studies demonstrate that fenbendazole exacerbates the hepatotoxicity of acetaminophen in part by reducing hepatic GSH levels. At present, it is not known if there are other components of the xenobiotic clearance system, such as drug transporters, that are altered by fenbendazole. Fenbendazole treatment of rodents has been shown to be an effective method for controlling nematode infestations. However, in view of its ability to suppress hepatic GSH, as well as cyp1a2 enzyme activity, care should be taken in utilizing this anthelmintic drug in rodent studies.” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3262853/

      Indeed, to prevent recurrence I would also consider anti-oxidants and antyinflammatory drugs and supplements. NAC and ALA are two of my favourites on anti-oxidant line.
      In prevention cases I would use Fenbendazole and other anti-parasitic drugs only in cycles, a few times/year, i.e. not continuous.

      Kind regards,
      Daniel

    1. Dear Jim,

      There is no specific discussion on how many grams of Fenbendazole/kg should be take. Usually people just follow what Joe Tippers used, as discussed in the article above. He used 1g granules (containing 222mg Fenbendazole) each day. Assuming he had an average weight of about 80kg, we end up with about 2.7mg/kg/day. In my view, this is a minimum quantity to take/day. This should help you to estimate how much could be taken for your weight.

      Kind regards,
      Daniel

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