Drug cocktail could double the average survival time

Dear Friends,

This is a short post to bring to your attention a result that was recently made public by Care Oncology Clinic www.careoncologyclinic.com in London. (Thank you Carl for sharing these news with me).

The Care Oncology Clinic is undertaking a study and providing treatments that may complement and enhance standard of care therapy but also used as stand alone. Essentially, they are using a combinations of four drugs that we often discussed on this website. Those drugs and the related dosages used are:

  • Oral Atorvastatin up to 80mg uid
  • Oral Metformin up to 1000mg uid, increased to bid if tolerated after 2 weeks
  • Oral Doxycycline 100mg uid
  • Oral Mebendazole 100mg uid

They have supported cancer patients with this combination for some years, and now they have reported results for Glioblastoma where this new combination treatment doubled the average survival time from 14 months to 27 months (Ref.). However, this approach is being applied for most cancer types.

The drugs are very cheap (several hundreds euro/year) and available in most countries. The anticancer mechanism behind Atorvastatin is believed to be related to cholesterol production inhibition (Ref.). The main anticancer mechanisms behind Metformin are related to glucose lowering effects but also related to it’s impact on mitochondria (Ref.). The anticancer mechanism behind Doxycicline is related to it’s impact on mitochondria. The main anticancer mechanisms behind Mebendazole it’s related to interference with microtubule dynamics (Ref.).

The result from Care Oncology Clinic demonstrates that life extension can also be obtained with cheap and available drugs that are accessible to most of the people.

To me, this is just a taste of the value confined in the academic space and waiting to be exposed. And it hits at the core of my goal: exposing valuable discoveries from academic world that can be fast implemented to improve and extend life of cancer patients.

Due to reasons discussed here, to the above cocktail I would also add the following:

  • Dypiridamole 200mg 2x/day
  • HCA 2-3g/day
  • Bioperine 30mg/day
  • Aspirin 100mg/day
Also, in my view Mebendazole dose should be at least 200mg/day and should be taken with (fatty) food to improve it’s absorption. Next to these, adding probiotics would help to reduce side effects of the Doxycicline. Best probiotic is sauerkraut.
Kind regards,

Other References:

Update 2019: A New Method for Ethical and Efficient Evidence Generation for Off-Label Medication Use in Oncology (A Case Study in Glioblastoma) https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6610246/
In oncology, preclinical and early clinical data increasingly support the use of a number of candidate “non-cancer” drugs in an off-label setting against multiple tumor types. In particular, metabolically targeted drugs show promise as adjuvant chemo and radiosensitizers, improving or restoring sensitivity to standard therapies. The time has come for large scale clinical studies of off-label drugs in this context. However, it is well recognized that high-cost randomized controlled trials may not be an economically viable option for studying patent-expired off-label drugs. In some cases, randomized trials could also be considered as ethically controversial. This perspective article presents a novel approach to generating additional clinical data of sufficient quality to support changes in clinical practice and relabeling of such drugs for use in oncology. Here, we suggest that a pluralistic evidence base and triangulation of evidence can support clinical trial data for off-label drug use in oncology. An example of an off-label drug protocol brought to the clinic for glioblastoma patients is presented, along with preliminary retrospective data from the METRICS study (NCT02201381). METRICS is a novel participant-funded, open-label, non-randomized, single-arm real-world study designed to gather high-quality evidence on the safety, tolerability, and effectiveness of four off-label metabolically targeted medicines as an adjunctive cancer treatment for glioblastoma patients.


This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

Please read an extended version of the Disclaimer here: https://www.cancertreatmentsresearch.com/?page_id=1794


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123 thoughts on “Drug cocktail could double the average survival time

      1. This is really a wonderfull post.We need a page like this from years.We already know the mechanisms and these drugs but it shows us the power of combos.
        Not only cancer,also other illneses need more targets.
        We have more powerful drugs here to add into combos.
        But with care ofcourse.

        1. Thanks Ergin, but you know … sometime ago I wrote a post where I developed a strategy that I think is very good and actually 3 of the 4 drugs listed above are included in that strategy (statin, metformin & doxy), but I think that cocktail I proposed is even better https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/ since it includes also a drug that helps maintaining Statins effectiveness, plus a few others.

          Another cocktail of drugs addressing a different weak spot of cancer cells is discussed here https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/

          1. Hi Daniel,
            I missed some word so the meaning changed totally.
            Ofcourse this is not the best combination that you wrote.
            This website is a treasure as i wrote lots of times.
            But what i like is they wrote clearly the survival benefit of these combos.And we can add more powerful ones which we learned from you.Sorry for misunderstood.?
            Kind Regards

            1. Hi Ergin,

              You are right with two things:

              1. this website contains a lot of relevant info but it is still complicated for many. People usually prefer a simple summary. I realized that, and from time to time I will publish simple posts like this.

              2. It’s great to have a clear statistics after using these drugs – since people are always wondering if these drugs indeed help or not

              Kind regards,

      2. Hi Daniel.
        You end up your article with “Best probiotic is sauerkraut.” Would kimchi be equivalent as a good probiotic?
        Thanks, appreciate your help.

        1. Hi Mario,

          Yes, and I like it a lot! 🙂
          Btw, sauerkraut can be easily made at home – you will find the info on how to prepare that online.
          My mother is making it for me. It can be stored for long time at lower temp so you don’t need to make it too often.

          Kind regards,

          1. Daniel, I don’t know if you fully realize what a positive impact you have on the lives of all cancer sufferers and their caregivers. I thank you from the bottom of my heart for your tireless dedication to answering the most trivial of questions.

            1. Dear Mario,

              You are so kind. Thank you so much. It’s important to give credit to so many people who are helping here with answers for so long time, such as Johan, Shanti and so many other friends. we are doing our best. We do not know everything and often we need to research in order to answer questions, but together we do our best to add value to life of people. Thank you again for your valuable feedback.

              Kind regards,

  1. Hi Daniel-
    Thanks for this post, I have been eager to see some of the results from the Care Oncology Clinic and also to know exactly what they were using. This will also be valuable information for me to share with my colleagues who are actively consulting with cancer patients.

    1. Hi Shanti. Thank you for further sharing the info and thank you to those kind visitors of this website such as Carl in this case, and all the others coming here not only to pick up information but also sharing back with others their findings.

    1. Thank you Vasis. It’s important that we put all info that comes to us, into the context. The context, created by a very large amount of published research, points to the fact that Metformin adds value not only in the lab but in humans as well. In this context, the article referenced above comes as an outlier. Here is just an example I quickly found: a clinical trial (published in 2018) showing Metformin adds value for lung cancer patients in this case https://www.ncbi.nlm.nih.gov/pubmed/29487223 but you will find many many supporting this view.

      There is always a specific case and lab setting in which you can show something is not working. There are many research groups in this world who have a “contrarian” approach in research. This is also useful for advancement of knowledge but is less relevant for us here. Thanks again for the share. Always appreciated!

        1. Thanks Vasi. Interesting and valuable results from the Ukrainian group. Regarding my previous response, my general approach is such that in order to deal with the huge amount of info available in this world, I need to fly across and pick up the patterns. Only stop when the info has the potential to change the previous conclusion. Pieces of info such as the one you shared on Metformin are parked in my mind, and if I come across more of the same that would generate a pattern, I would stop and reconsider my view.

    2. Well, my mother is still alive. Maybe not because of Metformin, but it sure saves us from having to deal with Morphine shots for her pain, in conjunction with aspirin or diclofenac.
      So we can still talk, like mother and son instead of having to care for a semi-concious person, i can still talk to her.
      To us, these are the most valuable pills next to the oncologic protocol.


        1. Brother, there has been some shrinkage in some areas and growth in others. Oncologist is continuing treatment. With Tarceva and Zometa
          No cancer in other organs. We didn’t do any blood tests or markers.
          Mother is not happy, but the doctor said she should be happy to be able to talk to me for another day.
          The doctor explained to her that if it wasn’t for the treatment she would have been dead by now.
          I can’t say i believe that to be absolutely true, because the original tumor was bigger before surgery.
          The doctor encouraged my anti-inflamatory proposal. So i give her 250mg Aspirin, 500mg metformin, once a day with food, i also apply diclofenac cream where i see the tumor on her back in the CT scans and where she is saying it hurts. I am thinking of mixing diclofenac and ibuprofen cream together for skin application, maybe it does better.
          So far we’ve managed to avoid the nightmare of morphine shots. To me this is a miracle…. we can have conversations, she can sleep or enjoy a show on tv or even browse facebook and such. Most of the time she watches cooking shows on tv, as she loves to cook and wishes to get back in the kitchen, it also helps to motivate her, and every bit helps because things are so bad.
          She is still very much paralyzed so, everything is very slow and hard, humiliating.
          She has side effects problems from Tarceva…. skin problems, infections, inflamation of the liver, so i buy creams and anti-biotics, and Silimarin.
          There are many drugs but i don’t want to kill her with too much toxic drugs.
          I don’t know what more to do, i help with everything i can… i am alone in this, i don’t have time to think very much.
          I don’t know how much time we have, maybe 3 months, maybe 6 or more, depends on many things.
          I am happy she is not suffering from cancer pain, the rest… we wait for destiny.
          If situation becomes more critical, and doctor is abandoning, we will try what we can.
          But what? My mother has very strong cancer maybe not very metastatic, but strong, drugs don’t affect it very very much, just a little. It’s very flexible. Here it dies, and there it grows. Genetic variation, resistence, adaptability.
          I don’t know what to do more brother, too much pain, and i can only imagine what it is like for you.
          Sometimes i try to be a man that i am, and not cry, but it’s too hard. Your losses shocked me bro, i saw your emails, but i still wait for you on skype.

          Good luck,

          1. Dear Alex

            I know how bad you feel , you feel like treatment is not going good and tumor is trying to grow even with Tarceva

            but don’t take it hard on yourself

            first, do doctors tell you that there is no option other than Tarceva ?

            i don’t think that Tarceva is the only option, normally the oncologist should have good options as long as patient is stable , my mother where almost stable for 2 years , getting up and down everytime

            what i’m telling you is to not think like things are going bad , i want you to know that you have time

            there is good and enough time to think about new options

            did you try treatments like MG ? Thalidomide ? Taurolidine or the combo mentioned in this article ?

            i know that maybe 3bp is hard to get , but you should plan on using some of these options

            take me as an example

            3 weeks ago , i thought its over

            my mother had severe ascites , and you know the very poor prognosis associated with it

            but its just some bad thoughts , ascites is gone now , and she feels a lot better these days

            ok i can’t take any rest at all, i don’t know what will happen in the future

            but my message to you is : don’t think that time is up , we have been in almost same situation for 2 years at least , so i advice you to plan for trying new things , you may face more up and downs but this is our best we can do , we hope that soon we could deal with cancer and get it killed somehow at the end , its very very hard fight but not impossible to win it

            wish you all the best for you and your dear mom

  2. Thank you so much Daniel, useful information

    i only used 2 of them for some time , the other things are still new to me , they deserve a serious shot 🙂

  3. Hi, Daniel and friends 🙂 !

    Thanks for this post.
    Did You have typing mistake or what is HCA? Maybe You meant DCA?

    I have heard that in some progression cases COC gives acyclovir.

    Thinking of all of You !


    1. Hi Ieva, nice to hear from you and thanks for pointing out Acyclovir. I will have a look at it but I do like the idea of using antiviral drugs.
      Here I wrote a post about HCA sometime ago https://www.cancertreatmentsresearch.com/another-weak-spot-of-many-cancer-cells-atp-citrate-lyase-inhibition/
      And here I integrated that in to a more comprehensive cocktail focused on one of the important weak points of cancer related to the high cholesterol need for cellular division https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/

      Kind regards,

  4. So my mom is back home now, it’s been 2 days.
    Appears to be stable, got her an oxygen concentrator.
    I thought she was going to meed her end, so much so that a lot of relatives came to the clinic to visit one last time.
    A pastor and a priest were brought there. Photos, videos…. final words.
    In many ways we are very lucky, in others, extremely unlucky.
    It’s been a nightmarish second half of the month for me and her.
    In the clinic like i said before, the oncologist gave her 3 or 4 itraconazol pills of 100mg, each time my mom took one every day, she felt better, it’s true she also got iv’s with Vit b1, Dexamethazone, B12, Omeprazole, Algocalmin, others…
    So yesterday and today she took itraconazol, and apparently it helps.

    What intrigues me and i find it confusing in a good way?! She is saying she has more dexterity in her left hand after she takes itraconazol 100mg.
    She wants to continue taking itraconazol 100mg/day for 2 weeks, a brake and then another 2 weeks and so on.
    Someone else on facebook brought up nistatin as a possible drug that would help
    Back to itraconazol now, i just don’t know what to think, how is it helping her? If it is actually helping her, is this a drug i can have hopes for actually making my mom more functional, nervous system is damaged maybe completely beyond recovery?
    Both her arms were paralyzed, but after these 2 weeks in the oncology clinic, her right arm recovered good, not fully.
    Today after one itraconazol she could move her left arm fingers individually, but not with strength and not fully.
    She could do so yesterday too, but less than today. I hope i am clear enough.

    Either way, it’s all fake news from the doctor, looks like i won’t be doing any iv’s to my mom. the doctor simply said what we wanted to hear i think.
    Her treatment for now is still Zometa+Tarceva however my mom doesn’t want to take Tarceva… so she hasn’t been taking it.
    Mostly due to the side effects on her skin and nails and hair growth, also arguing that “if it doesn’t heal me, than what’s the point of taking it? It’s been 10 months”
    Hard to say anything against that, i mean i tried, in a way she is right and i want to allow her the freedom of choice.

    All and all, crazy enough she has no distant metastasis to some organ, still not late for that to happen tho.

    Perhaps this comment should serve as a reminder to me and others here reading, the basics should always be on our list.
    If not to cure, to at least improve quality of life and maybe gain a few more minutes to say what counts the most.

    Many many thanks
    Have a wonderful weekend,

  5. Hello Daniel. I think that Care Oncology Clinic used 1 month Mebendazol, 1 month Doxycycline.

    We started this protocol about 3 months ago. My father was already taking Metformin and Mebendazol, so we added just Atorvastatin and Doxycycline. Stopping Mebendazol scared me, so we decided to keep it all the time and we take doxycycline a month and a month off. I don’t know if it’s a good tactic. We also decided to add liposomal vitamin C while taking doxycycline, which I found interesting.
    It’s odd because the markers went down while taking doxycycline, but as soon as we stopped doxycycline it went up a lot. Unfortunately, obviously we can not use doxycycline all the time, so we have no choice.

    1. Hi Dess,

      I think you found the point where the COC combo needs improvement. It is known from literature that Doxy induces inhibition of respiration in a reversible manner so that cellular respiration is recovered after Doxy removal. And if the cancer cells were not killed they may be more aggressive after Doxy removal, since the cancer cells acquire an upregulated glycolisis during Doxy treatment.

      COC combo it is more focused on reducing mitochondria activity/respiration (due to Doxy and Metformin). If this works in a patient like your father, the opportunity I see is to inhibit glycolisis as well at the same time with respiration inhibition. Having a strategy to address both mitochondria and glycolisis, is best and may help to kill cancer cells so that they will not be able to recover after Doxy removal.

      This is why by going towards Vit C you’ve made a very good step I think https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5620172/ However, the question is if the liposomal vit C will be effective enough as a glycolisis inhibitor. Using the IV route next to liposoal would be better. Or even better is adding more effective glyco inhibitors such as 2DG. If you have a doctor to administer 2DG in a legal context, I can connect him with the medical doctors able to support him (for free). Oral admin could also be an option but possibly less effective. I discussed various metabolic inhibitors here https://www.cancertreatmentsresearch.com/category/metabolic-target/page/2/

      Overall, I think it’s a good sign that the markers were going down while on Doxy and now would be best to add to that an effective glycolisis inhibition strategy.

      Kind regards,

      1. Hello Daniel.

        Thank you for your answer and the nice proposal. Alas, we have no doctors and no nurses to do such infusions.:-/ That’s why our only option is the oral route. We try with 6 grams of liposomal vit. C. I think that probably by combining several substances we are more likely to have an effect? Maybe continue vit. c, 2DG, maybe berberine ( even if he already takes metformin) and today I discovered niclosamide – would it be appropriate? Since recently daddy has also been taking DCA, chloriquine and hi is on irinotecan.
        I try to understand, but I admit that things go beyond me, it’s quite difficult to understand and I have the impression that by wanting to do something good we make some pretty serious mistakes.:-( I think our schema failed because of the way we organized things – we stopped doxycycline for a break at the same time as vit. C, and now I realize that we maybe not have to stop vit c. But how to do it then… – continue vit c and 2 dg all the time, or take them during the break of doxycycline? Again how long can it finally take doxycycline and with what poses?
        I saw your article on meclizine, I saw that it also induce inhibition of respiration (?)- would it be appropriate to take it for example during the doxycycline break in your opinion?
        I am sorry that my post is so long and I have so many questions, I can’t find a solution and your help is very precious.
        I also have one last question – do you know which Chinese supplier offers 2dg? Sigma is unfortunately really too expensive for us (it’s the same product for oral and interveinous use I think).
        Thank you !!!
        Best regards !

        1. Hi Dess,
          Sorry to hear what you are dealing with.
          İf the tumor is visible,there are some good choices like direct intratumoral injections.
          Here is a video about intratumoral injection of bicarbonate+ozone.May be it gives an idea to you, i dont know.
          Hope all things go perfect with you.
          Best Wishes

            1. Hello, Ergin.
              Thank you very much, I watched the video, it looks interesting!! I will share with a friend whose cancer is located.
              Unfortunately daddy’s is in the stomach and with metastases in a large part of the lymphatic system. 🙁

          1. Ergin – just thought I’d mention that youtube is of an intraperitoneal injection, which is an injection in the into the peritoneal cavity, not directly into the tumor. A tumoral injection of this substance could possibly have disastrous consequences (think of an internal bomb full of cancer cells). Anyway, an interesting treatment.

        2. Hi Dess,
          I purchased my 2DG from a Chinese supplier:
          David Hong
          Tel: +86-18663380771
          [email protected]

          I contacted multiple suppliers before deciding on this one for two reasons: 1) They were able to supply me with a certificate of analysis (COA) 2) they claim to be GMP compliant and to be the supplier for Threshold Pharmaceuticals and I although I can’t find the email now, I believe they also supplied several studies on 2DG with the material. Anyhow, I paid via paypal and received the product within a week. They even followed up to make sure I had received it. Here are the quotes I was given in USD, but keep in mind they may have changed:

          25 grams pharmaceutical grade 2dg is USD 75 + USD 30(shipping cost)=USD 105.
          50 grams pharmaceutical grade 2dg is USD 150 + USD 30(shipping cost)=USD 180.
          100 grams pharmaceutical grade 2dg is USD 280 + USD 30(shipping cost)=USD 310.

          1. Hello Shanti.
            Indeed, it is much cheaper! Thank you very much for the coordinates. Have you ordered via a website or email? You used it orally? I don’t understand if we can drink it as is, just with water.

            1. Hi Dess,
              We ordered after corresponding with “David” via email and were given the option of paying via western union or PayPal. I chose paypal and he sent me a PayPal invoice, which I managed to pay with my credit card even though it was in Chinese. I got a receipt right away and received the product within a week. I would suggest sending him an email, let me know if you don’t get a response.

              We used the 2DG orally along with metformin, DCA, fenofibrate, artemisinin, and LDN. Now that I have a better understanding of these substances I would not take DCA (which “forces” the cells to use the mitochondria for cellular respiration and causes oxidative stress leading to apoptosis in cancer cells) with substances that inhibit mitochondrial energy production (fenofibrate and metformin).

              We are no longer using these medications as my husband is currently in complete remission (on androgen deprivation medication), but we have them in reserve in case we need to use them again. As you know, 2DG shuts down glycolysis, but I believe that the power of 2DG comes in using it in combination with other substances that also inhibit energy pathways the cancer can use. A ketogenic diet (as long as the cancer is not hormonal) can help to limit the cancer’s fuel source further and using vitamin C and Doxy also inhibits glycolysis and the mitochondria respectively. The drugs from COC also work along these lines. It seems that many medications used off-label for cancer work to block some aspect of cancers altered and accelerated metabolism, however, DCA is different in that it accelerates mitochondrial respiration. Therefore, it may be worth alternating DCA with mitochondrial inhibitors instead of using them at the same time.

              I agree with Daniel that 2DG is best used spread throughout the day. We simply mixed it in a little water and drank it. Tomorrow when I have my dosing sheet with me I will let you know what dose we used.

            2. We used 10mg/kg twice a day orally. People do use much more than that but it is probably best to start with a lower dose and work up. Here are some studies indicating varying oral doses:

              Targeting Tumor Metabolism with 2-Deoxyglucose in Patients with Castrate-Resistant Prostate Cancer and Advanced Malignancies (2010)
              45mg/kg (Dose-limiting toxicity was found at 60mg/kg because of asymptomatic interference with heart rhythm that was detected on an EKG )

              A phase I dose-escalation trial of 2-deoxy-D-glucose alone or combined with docetaxel in patients with advanced solid tumors.(2013)
              63mg/kg was selected as the clinically tolerable dose.

              Some expected side-effects are symptoms of hypoglycemia as the 2DG competes with sugar in the energy pathway of glycolysis. A higher tolerated dose should be achieved by spreading throughout the day and this would also increase the efficacy.

            3. Hello Shanti.

              Thank you very much for your response, it’s a very nice to have shared this information. I am happy for your husband!!! The good news give hope too.

              I’m write to Everest biotech, I wait their response. For the dose I think start with 2g per day like stipulated in Daniel’s article. We’ll separate in 3 or 4 taken, or more is better ? My father weighs about 65 kg.
              I see that you have used doxycycline too. How do you have done – during how many days and with breaks during how many days? We have tried 1 month-making and 1 month-off, but I don’t know if it’s well.
              Thank you again and have a nice day!

            4. Hi Dess,

              We haven’t actually tried the doxycycline with the vitamin C, but have considered it and have Doxy on hand. It is a little tricky to know what doses may be effective because the study on the Doxycycline/vitamin C combo is a cell culture study. I decided to attempt to approximate a human dose as we are also interested in the Vitamin C/doxy combo. I noticed you are also using some of the other medications tested in the study.

              Here is link to the actual study: http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=view&path%5B%5D=18428&path%5B%5D=59195 and here is one to a nice summary: https://www.sciencedaily.com/releases/2017/06/170612094405.htm

              In the study, the cells were first cultured with doxycycline for 3 months, this shut down the mitochondria and forced the cells to rely on glycolysis alone. After that, the vitamin C was added, inhibiting glycolysis and causing death of the cancer stem cells.

              On the vitamin C side, here is a quote from the study:
              “[vitamin C] inhibited DoxyR CSC (doxycycline resistant cancer stem cell) propagation by > 90% at 250 µM and 100% at 500 µM. As such, the IC-50 for Vitamin C in this context was between 100 to 250 µM, which are within the known achievable blood levels, when Vitamin C is taken orally. ”
              Translation: You can achieve blood levels of at least 100 to 250uM by taking vitamin C orally (maybe better with liposomal). At this concentration of vitamin C, at least half of the doxycycline-treated cells would be inhibited. Of course, blood concentration is one thing, and concentration in the tumor environment is another.

              Regarding Doxycyline: In the study, the doxycycline concentration was 50 uM when the vit C was added to the cell culture. The concentration of 50uM used in the study would convert to a concentration of 22.22 mcg/mL (ideally we want this in the tumor environment). The prescribing info on Doxycline pharmacokinetics shows a peak plasma level of 3 mcg/mL in blood after a single oral dose of 300mg. So we are theoretically short of the target dose on the doxycycline side, although it could be increased somewhat by twice daily dosing or IV. However, we don’t know the minimum effective concentration of doxycycline, all we know is that the concentration in the cell study was 50uM.

              What does all this mean? I think it is easier to reach the right concentration of vitamin C and harder to reach the doxycycline concentration, however, it is possible that the effective doxy concentration is lower than that used in the study. I certainly think the approach is worth a good attempt.

              If I were starting from ground zero, I would probably give doxycycline first in the highest tolerated/safe dose for a couple of weeks and then add in the Vitamin C as high as I could go (using IV if possible) and oral in divided doses, as you would want the maximal blood levels for as much of 24 hours as possible. However, for someone who is already taking the vitamin C, it seems best to rotate the doxycycline in as you have been doing and to combine it with other metabolic inhibitors that are continued when not using the doxycycline. This is my best opinion but I would love to hear other thoughts. I haven’t looked into how long to take doxy for and how long to take a break.

              Doxycyline prescribing information.

              How to convert uM to mcg/mL
              Doxycycline has a molecular mass of 444.43 g/mol.

            5. Hello Shanti.
              Thank you for all those informations!!!

              I see things exactly like you. We have started doxycycline again (after a month off), this time I will start vitamin c towards the end and I will add other things (I am looking especially for niclosamide and meclizine). I will order 2-dg, thanks again for the contact!!! They will sell me 100 grams for 334 dollars with the port (to France). As soon as we analyze the markers I will communicate the results.

              Best regards,

            6. Hi Dess-
              I’m glad you got a response back on the 2DG and I hope you are very successful with all that you are doing. Since your dad’s cancer is in the stomach, maybe it will be easier to obtain some of the target concentrations of Doxy and Vitamin C. What dose of doxy are you using? I noticed that doxycycline is used for malaria prevention for travelers at 100mg per day during travel in the affected area and for 4 weeks after returning home, but it is hard to find other examples of its use in the higher mg amounts for long-term. Lower doses are used for ongoing acne treatment. I’m sure you are doing this, but taking a probiotic while on antibiotics (taken the same day but spaced away from antibiotic administration) can help with the intestinal side effects.

            7. Hello Shanti.
              Yes, it’s exactly that – he takes 100 mg per day, as for malaria protection.The first time he has price doxy for 40 days, he paused for 30 days and he started again at the beginning of month. He’s taking probiotics too. Indeed it also takes other drugs and supplements. I really believe that doxy is working for him.When he started taking it the markers dropped. When he stopped it they increased. Then a few days ago they were down … It’s a shame that it’s something we can not take all the time and a resistance can appear.
              Best regards

            8. Hi Dess, thank you for your reply. With continued well wishes for you and your dad -shanti

            1. Hi Alex,
              We are not currently using it as my husband has responded well to other therapies (androgen deprivation and other alternative therapies we are using) and is currently in remission. We used 2DG in combination with other medications (see my post above), but it is hard to know the impact because around that same time my husband started with the androgen deprivation. We continued to used the 2DG and other meds for 10 days out of every month but eventually opted not to continue with them because of the impact quality of life. My husband was already experiencing fatigue as a result of the androgen deprivation meds (zytiga and lupron) as well as prednisone and xgiva, and the 10 days we did the off-label meds really really wiped him out. We were able to determine that the LDN, in particular, caused him fatigue and we had to take half of the suggested dose for DCA to avoid nausea and vomiting. He did pretty well with the 2DG, taking it twice a day (I’ll check the dose he took tomorrow). We noticed that a period of lowered energy followed the 2DG and that this was dose dependent but tolerable. I would absolutely consider using the 2DG again if we need to.

            2. Hi Alex,
              We used 2DG 10mg/kg twice a day orally in water. We used it along with DCA, fenofibrate, metformin LDN and artemisinin. Hard to know if we had a response because androgen deprivation was started around the same time.


          2. Hi Shanti, thanks a lot for this. Very well priced indeed. Receiving the product in one week from China seems very fast. May I ask where you are located? No problems with customs? Did the supplier label the parcel in any particular way?
            Thanks again!

            1. Hi Carl- I am in Florida in the United States. It was sent in a large envelope, which I believe was non-descript. We had no trouble with customs. The 2DG was inside in a plastic bag labeled as such. It was a white powder with a slightly sweet taste. Based on my correspondence with the company, the nature of the powder itself and my husband’s response to it, I don’t have reason to doubt its identity.

        3. HI Dess,

          1. For 2DG, I am helping doctors & scientists from US to start trials in countries where 2DG is allowed to be given to patients. If you are interested, I will keep you up to date on this one.
          2. Niclosamide is one of those re-purposed drugs that are on top of my list. The anti cancer potential is high but the absorption is not the best. However, for stomach cancer absorption should be not such an issue. Same with Pyrvinium https://www.cancertreatmentsresearch.com/pyrvinium-pamoate/ So I would certainly try these drugs for one-two weeks cycles.
          3. When it comes to cancer, things go beyond everyone, not only you Dess. Otherwise it would not be one of the major challenges of humanity. The point is that in everything we do we should be as informed as possible. That information combined with our feeling should help us decide if we should act or not on a specific route. We will never know everything, and the more we know the less it seems we know – so I understand your feeling. What helps me in this case is knowing that I do the best I can to the best of my knowledge.
          4. Speaking about Irinotecan reminded me of the treatment strategy of Dr. Masada. Maybe you could also consider this approach that dr. Masada uses in various types of cancer https://www.cancertreatmentsresearch.com/thalidomide-once-alleviate-morning-sickness-in-pregnant-women/#comment-2208
          5. I think Meclizine is a nice addition indeed
          6. For the Chinese supplier, you already have an answer from Shanti – if I would use 2DG, I would take the daily dose spread across the day and night in multiple doses. That is expected to lead to a higher effectiveness compared to one or two doses/day

          Kind regards,

          1. Hello Daniel.

            We are interested in trials with 2dg, but I don’t know if this is allowed in our country. My father is bulgarian, but he cares in France (that’s where I live). We are generally satisfied care and conditions at the hospital, but doctors are usually quite conservatives for all that is not official.

            This is a longtime since I think about thalidomide, but two problems arise to us:
            – My father was thrombosis, was under anticoagulants and upon stop it took a pulmonary embolism. He still sequelae and now he’s got to inject herself with tinzaparin every day. Doctors said that he was very susceptible to tromboses. On the other hand I have seen that we should not use AAS with tinzaparin. Step 2 (molecular targeted drugs) seems problematic, so do the protocol of Dr Masato is suitable for him?!
            – The second reason is the difficulty to obtain thalidomide and its price. If we decide to use it, could you send me coordinates of the plant where you had purchased, please!

            Thank you again for all!
            Best regards,

            1. Hi Dess,

              You could try to send a msg to Dr. Masada and see what is his opinion given the condition of your dear father. Also, you could check with your doctor and see his opinion. For a faster communication, we could also speak on Skype or Facebook, if you like. It’s always about balancing risks but indeed if thrombosis is a higher risk on short term vs. cancer evolution, I would probably not use Thalidomide.

              Kind regards,

            2. Hi Dess,

              You can try to reach dr. Masato by replying to one of his comments on this website and also contacting him via Research Gate – you can send a message there https://www.researchgate.net/profile/Masato_Hada

              For me having a call is more efficient – I am not thinking of typing, but a call via FB. If that is an option and you find it useful, and you have specific questions to address please let me know and we agree on a suitable time.

              Kind regards,

            3. Hello Daniel.
              Thank you so much for your availability and support! My english is unfortunately too bad to do a conversation especially oral. However if necessary in the future, I will find a relative to speak for me.
              Thank you again!!!
              Best regards,

        4. Des – You will only get to 450umol/L of vitamin C with liposomal-c, best case, and likely not even that. That is about 2x higher than is otherwise possible, but likely not enough to create substantial H2O2 necessary to shut down the ATP production that synergizes energy depletion in sequence with doxycycline. It will nonetheless be very beneficial. I’m going to tell you what others in your situation have done, and this is not medical advice, or advise of any kind at all, but upon hearing this you might have some ideas. The first is that IVC (intravenous vitamin C), even low dose IVC … as low as a target of 25g, will get you into the 5-10mmol/l range (10x-20x higher than what is possible with lipo-C), and is extremely safe. This dose is low enough that even G6PD-deficient patients can tolerate it. Your only concerns should be if he is unusually sensitive to iron (though this is only a theoretical contraindication, I don’t know of any reported problems) or if he is on iron supplements (which he’d need to stop during the IVC) because vitamin c increases iron absorption. The other contraindication is if he has significant renal challenges, in which case you’d probably want to go low and slow. That said, even just 1g/hr for a 5 hrs for example will get him into the millimolar range which will reliably shut down ATP production, and should be tolerated by even those with kidney challenges. There are no other contraindications than those I just mentioned (websearch PMC2898816). Because the extreme safety of IVC, many patients in your situation will then source the powder, sterile water, and needles and bags and do it themselves (no nurse needed). There are a number of Youtube videos on how it is done, like this (https://www.youtube.com/watch?v=AUunq6VvD-A&t=32s), but this has all the info you’d ever need: http://ivcbook.com/ebooks/IVC%20Administration%20Quick%20Reference.pdf. Note, at 25g and less you shouldn’t need the extra electrolytes, just 10g in 250ml sterile water, or 25g in 500ml, and sterile procedures.

  6. Guys, do you know a trusted chinese supplier for 3-BP and hydrazine sulfate? The one I found sent me a fake CoA, so I decided not to order from them. Thank you!

    1. You could try to check with the one suggested by Shanti. For own needs I usually ordered them from western suppliers whenever possible.

  7. Hi Daniel. This is Irfan. I had posted earlier on the forum about my sister with stomach and esophagus cancer. Can I have your email? i need your help. thanks you

  8. Hi Guys,

    2 months ago my dad, 67 was suddenly diagnosed with glioblastoma.

    After the biposy they were unable to take the tumor out.

    He has just finished his high dose 3 week radiation course and they told him they don’t advise chemotherapy.

    He’s still super active but on 2 tablets of steroids at the moment.

    We are based in Dublin, Ireland and feel the doctors have made a pretty lousy effort in treating him.

    I want to ask for advice on any refferals for drug cocktails i can research?

    I am open to all suplments, drugs, canibis oil or anything with a realistic chance of helping him.

    I started him on home made high dose lipsomal vitamin c, as per many guides suggest for this cancer.

    Recently i also saw this article


    about common drugs for treatment and also checked the offical clinical trial site.

    This form seems to have good insights based on good data.

    Can any one advise?
    I am really trying to find anything to help him before its too late.

    Kind Regards


    1. HI Paul,

      I am currently on holiday, traveling, but I understand the urgency so I will list below some links to info that will help you to focus fast on some of the most relevant info available regarding new/additional treatment options:
      1. In my opinion this document could be the best to start with https://virtualtrials.com/pdf2017/treatment_options_gbm_2017.pdf http://www.virtualtrials.com/pdf/williams1.pdf
      2. Next I would read this: “ CUSP9* treatment protocol for recurrent glioblastoma: aprepitant, artesunate, auranofin, captopril, celecoxib, disulfiram, itraconazole, ritonavir, sertraline augmenting continuous low dose temozolomide” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4226667/

      Others that are relevant:
      1. https://www.cancertreatmentsresearch.com/brain-cancer/
      2. https://www.cancertreatmentsresearch.com/taurolidine/
      3. https://www.cancertreatmentsresearch.com/dichloroacetate-dca-treatment-strategy/
      4. https://www.cancertreatmentsresearch.com/perillyl-alcohol-poh/

      Beyond this, there are more treatments discussed on this website that could be relevant but I think you would first need to go through some of the information listed above.
      On Yahoo Groups there is a Brain Cancer group that is good to join as they exchange relevant information.
      If you will start temozolomide (typical chemo pills for brain cancers) there are some ways that could help improve it’s effectiveness that we could discuss.
      I hope this helps.

      Kind regards,

      1. Hi Daniel thanks for your help, really shows your character compiling these while you are on holidays.

        I am going though all these now. Thanks again.

    2. @Paul: while the biopsy sample is still valid, you should find out a couple of things:
      – the MGMT status of the tumor; if MGMT is methylated, then the tumor may initially respond to TMZ, and there are ways to overcome acquired resistance to TMZ;
      – the HCMV (human cytomegalovirus) status of the tumor; if there is strong HCMV presence, then treatment with an anti-viral like Valganciclovir increases patient survival; HCMV infection increases stemness in glioma cells;
      – other mutations like EGFR, are they present or not; while currently used EGFR inhibitors reach poor concentrations in the brain, there are new ones which can cross the BBB (blood brain barrier), potentially helpful if the EGFR mutation is present;

      The drug cocktail mentioned in the article may help with various cancers, including GBM, but I have some reservations about Doxycycline, since at low dose it may help the cancer, and high doses are not tolerable for long.
      Statins (although more synergetic with Irinotecan than with TMZ, and best seems to be Pitavastatin), Metformin and Mebendazole can synergize with TMZ, but it’s not a sure thing, due to the heterogenous nature of GBM.
      Atorvastatin augments temozolomide’s efficacy in glioblastoma via prenylation-dependent inhibition of Ras signaling. PMID: 28554840
      Metformin and temozolomide, a synergic option to overcome resistance in glioblastoma multiforme models. PMID: 29348889
      Vinblastine and antihelmintic mebendazole potentiate temozolomide in resistant gliomas. PMID: 28852916

      The most promising chemosensitizer for TMZ against GBM is Macitentan, although so far only in a mouse model, where the combination lead to complete and durable regressions. Unfortunately Macitentan is expensive and won’t be paid by insurance, because it’s not an official cancer drug.
      Macitentan, a Dual Endothelin Receptor Antagonist, in Combination with Temozolomide Leads to Glioblastoma Regression and Long-term Survival in Mice. PMID: 26106074

      The CUSP9* protocol is just a proposal, but it includes some interesting ideas. There is a strong in vitro synergy between TMZ, Aprepitant and Ritonavir, the combination cytotoxicity against a glioma line was 78%, compared with 14% for TMZ alone.
      Antitumor action of temozolomide, ritonavir and aprepitant against human glioma cells. PMID: 26603162

      There are other possible ways to attack GBM, like the Bacopa monnieri extract, available on Amazon, although the effective dosage may prove toxic.
      Bacoside A Induces Tumor Cell Death in Human Glioblastoma Cell Lines through Catastrophic Macropinocytosis. PMID: 28663722
      Carmofur, a prodrug of 5FU, is effective against glioblastoma stem-like cells.
      Acid ceramidase and its inhibitors: a de novo drug target and a new class of drugs for killing glioblastoma cancer stem cells with high efficiency. PMID: 29348854

      Glioma cells have lots of lysosomes, and these are involved in protective autophagy; adding autophagy inducers and inhibitors to TMZ may overcome resistance.
      Temozolomide, sirolimus and chloroquine is a new therapeutic combination that synergizes to disrupt lysosomal function and cholesterol homeostasis in GBM cells. PMID: 29467937

      Less toxic adjuvants could be Melatonin (usually synergetic with TMZ) agonists like Agomelatine and Ramelteon, and by consequence be used for a long time.
      Agomelatine or ramelteon as treatment adjuncts in glioblastoma and other M1- or M2-expressing cancers. PMID: 26034396

      For patients who have the MGMT gene (not methylated), and can’t benefit from TMZ, a new option will be available, Tinostamustine.
      The first-in-class alkylating deacetylase inhibitor molecule tinostamustine shows antitumor effects and is synergistic with radiotherapy in preclinical models of glioblastoma. PMID: 29486795

      1. Dear ovidiu,

        With relation to this information, could you please refer to questions # 1 & 2 in my message below (Sep 10th, 4:14 PM) in this thread, regarding the hazard you provided about low dosage of Doxycycline? (Daniel answered my question # 3 and left the 1st 2 questions for you…)

        Many thanks,

  9. It seems Metformin doesn’t have a dedicated article, so I’ll post here. There is a strong synergy of Metformin and Syrosingopine, an old drug that is no longer on the market. Some people discussed this on Cancercompass, but there was no follow-up (like from where to buy it). Syrosingopine may be of interest to patients with bone metastases, since it seems to be an inhibitor of alpha enolase, which is expressed in lung cancer bone metastases.
    Syrosingopine sensitizes cancer cells to killing by metformin. PMID: 28028542

      1. No idea where to buy it from, except in bulk from chemical suppliers…
        I have to make a correction, Syrosingopine is not an inhibitor of alpha enolase, sorry… Quoting:
        “Syrosingopine binds the glycolytic enzyme a-enolase… However, we could not detect any inhibition of enolase activity by syrosingopine, although it was inhibited by the known enolase inhibitor NaF”

    1. A small update: there is a patent, US 8,993,587 by a team from Basel University (CH), which details more than the article, including the tested sensitivity of many cancer lines, to the Metformin – Syrosingopine combination, including A549 (NSCLC Kras mutant); Phenformin, withdrawn from the market in 1978, is much more potent in combination with Syrosingopine.

  10. The COC protocol is currently up for peer review and has had its data certified by a biostatistician company.

    The U.S. division is using a customceutical company out of Arizona to produce a high bioavailability portion of the treatment. I’ve been on it for 7 months and had the lesions in my spine completely heal. This was for a different tumor type.

    Updated information on the COC protocol for brain tumors and other tumor types is here: https://careoncology.com/faq/

    This article came out this week and shows that cancer is indeed a metabolic disease: https://www.news-medical.net/news/20180807/Study-suggests-cancer-to-be-a-metabolic-disorder-rather-than-genetic-disease.aspx Original source is oncotarget

  11. Hi All,
    Care Oncology has officially published their preliminary findings regarding the drug cocktail Daniel describes above and glioblastoma.
    A New Method for Ethical and Efficient Evidence Generation for Off-Label Medication Use in Oncology (A Case Study in Glioblastoma)

    Basically, they show a doubling of survival time in those receiving the cocktail. As there was an approximate 7-month delay in diagnosis to when individuals enrolled in the Care Oncology trial, my contact at care oncology believes the outcome would have been even better if they could get people on the medications as soon as they are diagnosed.


    1. HI Shanti,

      Thanks a lot for sharing the article.

      Many are often wondering how much value they gain from adding re-purposed drugs to their treatment protocol.
      This is a good and clear result. It shows that in average it helps doubling the expected life. And that is just after using 4 drugs.

      Imagine what can be done when addressing more of the relevant escape routes of cancer cells with drugs/supplements that we are discussing on this website … The only drawback is that when people know too much, they switch too often between treatments.

      Kind regards,

  12. Dear Daniel,

    One more question for today…
    I saw your answer above from May 1st 2019, about a possible better use of the doxycycline and mebendazole (than the COC protocol) but need some clarification.

    To your opinion, what is the reason that the COC protocol alternate the use of mebendazole (3 months) and doxycycline (1 month)?
    are they not allowed for continuous usage or they are not allowed to be taken simultaneously?

    And accordingly, what is the suggested usage protocol for these two?

    Many Thanks & good night!

    1. Dear Nissim,

      I think COC did a good job with their protocol. The value in that is the fact that
      – they use a combo of a few powerful anti cancer drugs
      – in a way simple enough that can be accepted and used by many patients
      – organised such that the patient can actually access the drugs with their help.

      However, the protocol can be improved. In my view, the decision to use alternatively MBZ and Doxy is related to the need to reduce the amount of drugs used at the same time, and logically it may also fit the way how an antibiotic is typically used. However, Mebendazole should be used continuously in my view, given that in the adrenal cancer case responding to MBZ, once MBZ was stopped the tumour started to regrow. Mebendazole is safe enough to be maintained for years.

      I would also improve the effectiveness of the Statin as discussed here https://www.cancertreatmentsresearch.com/cholesterol-lowering-statin-drugs-to-fight-cancer/
      To avoid the acceleration of glycolisis (due to Doxy and Metformin) I would use another MCT4 inhibitor (next to the Statin). A few are discussed here https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/

      You are very welcome and good night to you too,

  13. Hi Daniel,

    It’s me again, still in the same thread…
    Reading the posts in this thread add a lot of valuable information for us!

    It also raised another question related to the reply of ovidiu on Aug 4th 2018 to Paul, and especially:
    “The drug cocktail mentioned in the article may help with various cancers, including GBM, but I have some reservations about Doxycycline, since at low dose it may help the cancer, and high doses are not tolerable for long.”

    Generally, I believe this is what we all afraid of in any treatment, either labeled or off-labeled – helping the disease or weakening another therapy , in opposite to our intention and wishes…

    Questions –
    1. Daniel/ ovidiu – From which study does this hazard about low doses of Doxy come from?
    2. Which doses of Doxycycline are considered as low doses?
    3. Having said that Doxy is being used, 1 month on 1 month off (or more time off, depending on the usage protocol) – does stopping the Doxy usage after 1 month, cause a period of time where the patient body have low doses of Doxy or this is a meaningless period of time that can be ignored?

    Again, many thanks!

    1. HI Nissim,

      So far antibiotics are an important category of re-purposed drugs in the fight against cancer https://www.drugbank.ca/drugs/DB00254 I am working on an article on antibiotics and hope to publish that soon.

      COC suggests that Doxy helps their brain c patients, at a dose of 100mg/day as discussed above.

      Manuel also uses Doxy for her mom with GMB and while she was going not well more than an year ago when she was on TMZ only, she is better since he is using a large combo of repurpused drugs next to TMZ. She was stable for all this time, to my understanding

      So for question 1 and 2 I will let Ovidiu answer. Regarding question 3, when Doxy is stoped, one day after it’s gone out of the blood given its half-life of about 16h https://www.drugbank.ca/drugs/DB00254

      Kind regards,

    2. @nissim: the info I knew was several years old, Doxy required high doses to achieve direct anti-cancer effects, and could antagonize some conventional chemo. Besides that, adverse intestinal effects, and the activation of Ras at high doses, were not making it look promising.
      However, more recent info, about Doxy at 100 mg / day (low dose, which is probably tolerable long term), not alone, but in combination, targeting cancer cell metabolism, looks promising.

  14. Hi ovidiu,

    Thank you for your answer!
    So, to be sure I understood (and please correct me if required),
    1. For Doxy as a mono-therapy and low doses there is some hazard regarding possible pro-tumor activity.
    2. Doxy in combination and dose of 100mg/ day has promising anti-tumor activity.

    Regarding the 2nd option, could you please add some more info/ references to the combination with which the Doxy was tested with?

    Many thanks again!

    1. @nissim: by low dose I understand 100 mg / day, normal dose 200 mg / day and high dose 400+ mg / day; from my experience, normal dose can be tolerated for about 3 weeks, until intestinal problems become acute; high dose probably tolerated only for a week, low dose may be tolerated long term;

      1. Back then I wasn’t sure at which doses pro-tumor activity happens, it appears it’s mostly at high dose; check article:
      Doxycycline Promotes Carcinogenesis & Metastasis via Chronic Inflammatory Pathway: An In Vivo Approach. PMID: 2699875

      2. Low dose and combination may be used as chemo-sensitizer, but data is limited to one cancer line;
      Doxycycline, Azithromycin and Vitamin C (DAV): A potent combination therapy for targeting mitochondria and eradicating cancer stem cells (CSCs). PMID: 31002656
      Normal dose Doxy, for 2 weeks before surgery, can lower CSC markers in breast cancer patients;
      Doxycycline, an Inhibitor of Mitochondrial Biogenesis, Effectively Reduces Cancer Stem Cells (CSCs) in Early Breast Cancer Patients: A Clinical Pilot Study. PMID: 3036429

  15. Hi Daniel,
    I have one more question for today (hoping I’m not over asking… 🙂 )

    Regarding the recommended dosage of mebendazole (MBZ) to treat cancer and especially GBM cancer.

    The COC protocol is using 100-200 mg/ day.
    On the other hand looking at this in vivo trial with mice, MBZ and GBM cancer, the dosage was 50mg/kg /day, which is much higher. They also stated in the trial results that 100 mg/kg /day was not tolerable, while 50mg/kg /day was OK (for the mice):
    “Antiparasitic mebendazole shows survival benefit in 2 preclinical models of glioblastoma multiforme” – https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3158014/

    Also, I see that in treatment of cystic echinococcosis or alveolar echinococcosis in humans, the approved dosage of MBZ is 40-50mg/kg /day for at least 3–6 months or for at least two years respectively.

    Question: Is 100-200mg/ day of MBZ expected to be enough to influence the tumor activity? (and since there is no info from clinical trials, based on which information?) Does more than 100-200mg/ day expected to be intolerable? if not a problem, how about trying to reproduce the success (in vivo) with 40-50mg/kg /day?

    Many thanks!!!
    Regards, Nissim

    1. Hi Nissim,

      NI think COC protocol tries to stay on the safe side while still getting good value to the patients. Plesae check my post on Mebendazole https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/ 200mg/day were enough to see serious benefit in an adreno cortical carcinoma. Based on literature it should also get to the brain. 200mg in my view is very safe and higher doses even up to 1g/day and more have been used for months in children (see references at the link above). Another option instead of increasing MBZ dose is to add Fenbendazole.

      Kind regards,

  16. Dear Daniel,

    As you pointed out, Baicalein is very good against breast cancer cells (PIK3CA-mutated)(https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6248272/).
    Would you kindly let me know how can I purchase this on line via a trustworthy supplier in China that can actually supply pure Baicalein?.

    Looks like the only Food and Drug Administration approved drug that target PIK3CA-mutated is Piqray (alpelisib)

    I have a friend going to China next week and I may ask him to buy Baicalein – do you know the Chinese Character name for Baicalein?.

    Regarding Niclosamide (T.MAN PHARMA CO., LTD from Thailand)
    I read somewhere that due to its low bioavailability, 2 gram daily is inadequate. A dose of up to 4.5 gram daily would provide a better therapeutic effect to compensate for its low bioavailability – do you know if this is a reasonable safe dose (4.5 gram daily)?.

    How can I increase the absorption of 2 gram daily of Niclosamide?. It normally takes about 5 minutes to chew it properly to convert that to powder form, before washing it down with water.

    The CYP2D6 enzyme is one of the main enzymes involved in converting tamoxifen into its major active metabolite, endoxifen.
    Do you know if Niclosamide can affect and/or impair the efficacy of tamoxifen (20 mg daily)?.
    In other words, do you know if Niclosamide can affect the CYP2D6 enzyme?.

    As always, thank you very much for your help.

    1. Hi Raymond,

      I bought before Baicalein and others from a supplier I found on Alibaba. Here price was a little higher compared to others but I was happy with the quality [email protected]

      Here is a discussion on Niclosamide and increasing absorption https://www.cancertreatmentsresearch.com/fenbendazole/#comment-8833

      I am not aware of an interaction between Niclosamide and CYP2d6. Here is a list on some CYP2D6 inhibitors https://www.pharmacytimes.com/publications/issue/2009/2009-03/2009-03-10041
      For interaction of Tamoxifen with others you can use this interaction checker https://reference.medscape.com/drug-interactionchecker?src=google

      Kind regards,

        1. Hi Westie. If you insist you will probably get to her. If not, you need to contact suppliers on Alibaba and see which one you feel is a good one. In the end there are not many manufacturers and most of them are trading, buying from the same source. Just make sure that You contact some that are for long time active on Alibaba and have good reviews. And do all the buying via Alibaba platform not outside that. Kind regards, Daniel

  17. Hi Daniel,
    How are you?

    We have mixed feelings of “hoping to be on the right possible trail” as well as complete uncertainty and would appreciate your advice and thoughts, as well as any additional remarks from this blog members about the “NEXT non-standard treatment” plan below.

    General – current SOC:
    For the last ~3 months, my brother is having adjuvant chemo for the treatment of brain cancer (GBM).
    He had 1st two cycles of 4 weeks each with TMZ(5days) and 4 weeks ago updated (in the 3rd cycle) to 6 weeks cycle with CCNU(1day)+TMZ(5days).
    We hope to see good blood counts next week, so he will be able to start (within 2 weeks) the next (4th) cycle with CCNU+TMZ.

    Current non-standard treatment:
    Based on the ideas and understanding we got up to ~1 month ago, my brother is having (for ~4 months already):
    * Cannabis oil (RSO like, but with ~1:1 THC:CBD ratio)
    * Boswellia
    * Cucumin
    * Vitamin D

    NEXT non-standard treatment:
    Using this blog especially, we see some of the options and methods related to the metabolic treatment.
    Supplements are easier to get but some medications are harder/ impossible to get here (especially considering long period).

    Thus, we started 2 weeks ago and we plan to add, in the following order, 1 drug/ supplement per week (I have a clear gantt chart for this but cannot add a picture here, can I ?):

    [week# -2] started 2 weeks ago: Berberine (continuous) – we plan to gradually replace/add with metformin in the next few weeks
    [week# -1] Doxycycline (for 4 weeks) – we started with doxy and not mebendazole due to some very low risk to blood counts.
    [week# 0] Atorvastatin (continuous)
    [week# 1] Azithromycin (for 1 week, so finalize at same time with doxy) + Vitamin C – oral (for 2 weeks)
    >>> [Week# 2] >>> 4th cycle of CHEMO
    [week# 2] Vitamin C – IV (for 1 week)
    [week# 3] Mebendazole (for 3 months)

    Question 1 – any remarks about this order?

    Question 2 – any ideas about possible contradictions with the chemo (CCNU+TMZ) that is about to be in week# 2? (and then in week #8 etc.) due to ending Doxy right before the planned chemo, theoretically we need to take Vitamin C IV in the same week with chemo and we don’t feel comfort with this. Should some or all of these drugs/ supplements stop during the week of chemo or some time afterwards? (for example we thought of stopping mebendazole for ~2-3 weeks during and after the chemo due to possible blood count issues?)

    Question 3 – we also plan to get aspirin and try to get chloroquine. We will order bioperine and HCA to add as well. should any of these 4 not being taken continuously? same as the above question – any possible known contradictions with the chemo?

    Question 4 – we try to focus and know it is hard for my brother to take so many pills each day, so is there anything that you would drop from the above list? on the other hand, anything important that we are missing?

    Sorry for this too long message and too many questions.

    So many thanks for the help and best wishes,

    1. Hi Nissim,

      Here are my comments, and hopefully will get more from Johan and Manuel:

      1. Your additions look good. In general, I see a little more balance towards inhibiting mitho vs gloclysis. I think it’s good to add one more glyco (or GLUT) inhibitor such as Canagliflozin https://www.cancertreatmentsresearch.com/glucose-absorption-inhibitors-to-inhibit-tumor-growth/ But please check because I am not sure if it crosses blood-brain barrier (BBB)
      2DG would be another one but it would need to be used metronomic – intravenous
      Stiripentol as glyco (LDH) inhibitor would be great for brain cancer next to mitho inhibitors as those you use https://www.cancertreatmentsresearch.com/a-new-approach-to-improve-effectiveness-of-cancer-therapies-is-getting-ready-to-begin-human-trials/#comment-8010

      2. Syrosingopine and/or other MCT4 inhibitors from here should match the strategy used. Here are more MCT4 inhibitors https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/

      3. Choloroquine may be not needed every day as it has a long half-time

      4. As often stated, I would stop all treatments (capsules, etc.) expected to slow down tumors, about 3 days prior to the CCNU. But since you do this every week, I would take only 2 days off.

      Please contact Manuel and check with him too, what is his approach since he is using re purposed drugs for long time https://www.cancertreatmentsresearch.com/a-new-approach-to-improve-effectiveness-of-cancer-therapies-is-getting-ready-to-begin-human-trials/#comment-8002

      Kind regards,

    2. Hi Nissim,

      If you go to https://www.cancertreatmentsresearch.com/links/ you’ll find a link to my blog (on blogspot.com).
      There you’ll find a page with the details of my father-in-law’s recovery from GBM IV.

      Not only you’ll find the details on his treatment, but also information on new treatments and natural supplements that I think could help.

      Based on the results of the COC protocol with GBM so far, it makes a lot of sense to include this cocktail of 4 drugs into your brother’s treatment plan. I’m not really familiar with the details of protocol but I assume you’re following it as per the clinical trial.

      However, I’d love to see how the COC protocol minus the antibiotic would perform vs the 4 drug combination, in GBM.

      Antibiotic use in cancer treatment has its risks:

      I’m not sure the benefits are clear enough to justify the risk.

      Based on my experience I’d suggest you look into Tamoxifen, Melatonin, and Sodium Phenylbutyrate.

      Best Regards,


      1. HI Johan,

        It’s very interesting the link you shared. I haven’t read the article yet. I will look into it, as I think there are a few questions to answer related to the following:

        – it’s possible that the average survival of patients not taking antibiotics was longer because the investigators were looking at patients in a specific context, i.e. treated with immunotheraphy (in this case the group not taking antibiotics may, in average, benefit from immunotheraphy, while the other group not since antibiotics suppress the immune system)
        – it’s possible that the patients treated with antibiotics survived less because they were in a worse shape, the reason why they also needed antibiotics (they were not using antibiotics to fight cancer but fight infections).

        Kind regards,

        1. Dear Daniel and Johan,

          Thank you so much for your help!
          We’ll look into it deeper and try to do some adjustments accordingly.

          Could you please also look at my above review & questions, regarding my brothers treatment and next suggested treatment and advise accordingly?

          As I mentioned, we also try to stay in focus with not too many drugs/ supplements since it is not easy getting prescriptions from doctors here.

          Many tanks and best wishes!

        2. Hi Daniel, the study says “associated with even poorer outcomes across multiple tumour types independent of clinical factors”. Important study IMO, there’s definitely a need for further research into the (over)use of antibiotics in cancer.
          Best Regards

          1. Hi Johan,

            There is one new publication from the same authors, with the same title https://www.ncbi.nlm.nih.gov/pubmed/31292268
            I made a request and wait for the article as I have access only to the abstract at this point.
            However, in the more recent publication I see there is no more such as statement “independent of clinical factors”. This statement is unsuitable since there should be a reason (directly relate to their clinical status) why patients have received antibiotics either just prior to the check point inhibitors, or after that. In general, when a cancer patient requires antibiotics, it is likely that his/her condition is more challenging.
            Indeed we need to have a closer attention on outcomes related to the use of antibiotics, but while I was against them in the past, I tend to better accept them now based on various information I received during the past years. However, I would clearly not combine them with immunotherapy.

            Kind regards,

          2. Actually, there are more and more articles coming since 2018, suggesting the negative impact of antibiotics on the treatment outcome following Immune Checkpoint Inhibitor Therapy in cancer patients. It’s interesting so see it intensively discussed now by clinicians, since this is what science indicated for years. This is also what we discussed on this website for years https://www.cancertreatmentsresearch.com/gut-bacteria-amplifies-immunotherapy/
            Here are more of the recent publications on this subject:
            – Association of Prior Antibiotic Treatment With Survival and Response to Immune Checkpoint Inhibitor Therapy in Patients With Cancer. https://www.ncbi.nlm.nih.gov/pubmed/31513236
            – Antibiotics are associated with decreased progression-free survival of advanced melanoma patients treated with immune checkpoint inhibitors. https://www.ncbi.nlm.nih.gov/pubmed/30906663
            – Cumulative Antibiotic Use Significantly Decreases Efficacy of Checkpoint Inhibitors in Patients with Advanced Cancer. https://www.ncbi.nlm.nih.gov/pubmed/31292268
            – Negative association of antibiotics on clinical activity of immune checkpoint inhibitors in patients with advanced renal cell and non-small-cell lung cancer. https://www.ncbi.nlm.nih.gov/pubmed/29617710
            – Role of antibiotic use, plasma citrulline and blood microbiome in advanced non-small cell lung cancer patients treated with nivolumab https://www.ncbi.nlm.nih.gov/pubmed/31292005
            – Cancer Immune Checkpoint Inhibitor Therapy and the Gut Microbiota. https://www.ncbi.nlm.nih.gov/pubmed/31014119
            – Manipulating Gut Microbiota Composition to Enhance the Therapeutic Effect of Cancer Immunotherapy. https://www.ncbi.nlm.nih.gov/pubmed/31517538

            1. Excellent article you wrote on the topic, D. I hadn’t read it. Seeing how antibiotics can dramatically impact health(of the gut) it continues to amaze me how easy they are prescribed. How many cancer patients get an antibiotic if they get a strep throat infection, as an example? Most strep infections are viral infections, yet most doctors will just prescribe an antibiotic. Thanks again for your insight, good stuff!

  18. What are your thoughts on this?


    IPPIs are potent inhibitors of the OCT-mediated metformin transport in vitro. Further studies are needed to elucidate the clinical relevance of this drug-drug interaction with potential consequences on metformin disposition and/or efficacy.

    But there are contradicting studies too.

    PPIs did not reduce the effectiveness of metformin, and indeed were associated with a minimally better glycaemic response by − 0.06 HbA1c percentage points (95% confidence interval, −0.10, −0.01) in metformin initiators.

  19. Hi,

    Sorry for re-publishing this question (1st at the forum), as it became most important, I hope this thread is OK for this question.

    I would appreciate any help and advice from your experience and knowledge!

    My brother (45 years old with GBM brain cancer) is treated in the last 4 months by 6 weeks cycles of adjuvant 6 days chemo (TMZ+CCNU) + daily keppra (anti seizures).
    In between the chemo cycles (but not together), my brother is also doing combination of several protocols, including:
    * cannabis oil (CBD+THC 1:1)
    * fenbendazole, vitamin E
    * atorvastatin, mebendazole, metformin, doxycicline, (azithromycin and vitamin C are planned to be added for 1 last week before next chemo cycle)
    * boswellia, curcumin, berberine, vitamin D3, omega 3, astragalus, milk thistle
    * sugar free, low carbohydrates diet

    The main problem is that these pills are causing him to have slight nausea all day long and general feeling of stomach fullness, thus he have quite bad days, lower appetite and struggle to eat reasonably.

    Since he lost a lot of wight we are afraid he might have to drop some of these important hope-giving treatments.
    Looking at each drug side-effects, we suspected the metformine so he stopped taking it for the last 10 days but it is still about the same problem. Next suspect is the atorvastatin…

    Any ideas/ suggestions/ advise how to reduce this bad feeling due to taking many pills?
    – any specific supplement/ drug of the above known to be problematic?
    – Are soft-gels and capsules worsen the situation due to the coating?
    – timing for taking the pills?
    – specific food that might help?
    – any other advise?…

    Many thanks to you all!

  20. As Johan says, it is most likely that the loss of appetite and nausea is due to the temozolamide + CCNU combo. This is the typical side effect. I imagine he will be taking an antiemetic medicine like ondansetron (Zofran).
    It is possible that taking tmz + ccnu at night before go to bed and many hours after eating food could help

    1. Hello Manuel,

      Hope you and your Mother are doing well. I have read your comments in other threads and my understanding is that you have done tremendous amount of good work and highly valuable products for your Mom.

      To share with you, my Mother who is based in India, has been receiving treatment for Metastatic Triple Negative Breast Cancer. She initially had a good response to Chemo though in the past 6 months, each of the three scans have shown disease to be worsening at Liver, Bones and Lungs. The last two treatments also did not provide any benefit. She has a remarkable fighting spirit though disappointing reports have been taking a toll on everyone. 

      My sense is that you have got some experience with IV interventions using products like Phlorizin, Salinomycin and 2-DG. Would you be open to may be connect with me separately over email, my email id is [email protected] where I could seek some of your guidance and experiences to help improve efficacy of my Mother’s treatments. 

      I understand that you would already be very busy with your Mother’s treatments so I promise to keep my queries to a minimum. I very much look forward to hear from you.

      Best regards and early recovery wishes to your Mother!


      1. Hi Kapil,
        I hope to help you, although I have no more information than that shared by Daniel on this website but it will be a pleasure to help you in everything I can …

        1. Hi Manuel – My most sincere thanks for offering to help despite your own commitments. My email id is [email protected] if that is preferable for you.

          I am trying to source Phlorizin to give as IV (to increase the benefits of Chemo) from the source Daniel mentioned on Phlorizin page at:
          Do you have any experience with this seller. This one seems to be the only economical one but unfortunately despite multiple attempts to reach them, I am still unable to place an order.

          We are also considering IV 2-DG and IV Salinomycin. Though, I need to move very slowly and cautiously given my lack of knowledge and expertise in giving infusions. But, I am trying to gather some help for that. A bigger challenge being based in India is around sourcing these chemicals, particularly if imported from overseas. If you have any advice on that based on your own experiences, it will be very very helpful.

          Also, are there any special precautions to watch out with giving IV Phlorizin like may be blood sugar falling too low or any other potential things to be aware based on your own experiences. I am sorry if these are too many questions. Please take your time. My best wishes for your Mother!

          Many Thanks,
          Kapil Agrawal

    2. Hello Manuel, hope you are doing well.
      We understand from Daniel that you have developed a method to make the natural herbs more bio available and help crossing them BBB. Are you please be able to share your method? This would help us greatly for our 7 year old son who is battling with brain cancer- DIPG.
      My email address is [email protected].

      Many thanks.

  21. Dear @Johan and @Manuone,

    Thank you for the information,

    From what we experience, the 6 days chemo cycle every 6 weeks (1day*CCNU+5days*TMZ) indeed have its effects on general feeling, weakness and appetite but with correct timing of antiemetic medicine it is tolerable and luckily a few days after the chemo My brother is back to some normality and eat reasonably.

    The bigger problem is when ~3 days after the chemo he’s back to the protocol (supplements & off-label drugs). He say it is harder for him even more than the chemo, making him feel slight nausea and stomach fullness all day long, thus his appetite is very low.

    I see here some patients report having some protocols that consist of even more pills and with most of what my brother is taking and I was wondering what can we improve or what we do wrong?

    We’ll try the option of ginger & Nettle tea and also would appreciate any additional advices possible from members experience.

    Best wishes,

  22. From what you´re describing, Nissim, it could indeed be (in part) a consequence of the drugs and supplement cocktail. He might be very sensitive to some or various compounds on the cocktail. One way to try and find out what’s causing nausea would be by elimination, similar to an elimination diet to find food allergies. Of course, this would mean you’d have to discontinue the drugs cocktail and reintroduce one drug/supplement at a time. Also, not only the drug or herb but also the dosage could be the problem.

  23. Thank you @Johan,

    As we all know from daily life, it is seldom tasty to take an amount of pills and even “regular” capsules such as antibiotics doesn’t smell naturally good. Also, we noticed boswellia of one brand smelled particularly bad so we immediately changed to another brand.

    Actually, when he started the protocol we were very strict and added only one item at a time, every 3 days and it seems reasonably OK.
    Somewhere on the way, when the amounts raised my brother said he feels like his stomach is full with pills and it cause him to smell the pills and thus had bad appetite.

    So, we also suspect it is the combination of not eating good enough (half empty stomach) together with the large amount of pills 🙁

    We’ll try the ginger and nettle tea and hope it will make things better.

    Many thanks!
    Always open to hear new ideas and recommendations.

    Best regards,

    1. This might be a good opportunity to try different things. Also, IMHO it’s important any protocol shows benefits in a relatively short period of time, you´re in uncharted waters, there’s no point in continuing a drug(combination) if it’s not producing results.
      All the best,

  24. Hi,
    Happy Christmas to all!

    Did anyone happen to see this article from 2013, that was published in Journal of Clinical Oncology?
    “Effect of metformin and statins in high-grade brain tumors”

    If I understand correctly, it suggests the opposite from what I know/ assume so far – that the use of metformin + statin is involved in shorter overall survival of patients with high-grade brain tumors?

    I try to treat this article with caution, as I find no citations for it, but still this is the journal of ASCO…

    Any remarks/ thoughts/ additional info will be most appreciated!

    A happy new year, health and happiness to all!
    Best regards, Nissim

    1. Hi Nissim,

      Thank you for sharing the info. Another conclusion that can emerge from this study: There is a trend towards shorter overall survival of patients with high blood glucose + cholesterol level. The questions is how bad the results would be for these patients without having Metformin or Statins.

      This is a fair point, from the same paper: “The effect of diabetes mellitus, hyperlipidaemia, as well as sugar and cholesterol control deserves a larger cohort study in patients with high grade brain tumours.”

      A very happy Christmas and a very happy and healthy New Year to All!

      Kind regards,

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