This is a short post to bring to your attention a result that was recently made public by Care Oncology Clinic www.careoncologyclinic.com in London. (Thank you Carl for sharing these news with me).
The Care Oncology Clinic is undertaking a study and providing treatments that may complement and enhance standard of care therapy but also used as stand alone. Essentially, they are using a combinations of four drugs that we often discussed on this website. Those drugs and the related dosages used are:
- Oral Atorvastatin up to 80mg uid
- Oral Metformin up to 1000mg uid, increased to bid if tolerated after 2 weeks
- Oral Doxycycline 100mg uid
- Oral Mebendazole 100mg uid
They have supported cancer patients with this combination for some years, and now they have reported results for Glioblastoma where this new combination treatment doubled the average survival time from 14 months to 27 months (Ref.). However, this approach is being applied for most cancer types.
The drugs are very cheap (several hundreds euro/year) and available in most countries. The anticancer mechanism behind Atorvastatin is believed to be related to cholesterol production inhibition (Ref.). The main anticancer mechanisms behind Metformin are related to glucose lowering effects but also related to it’s impact on mitochondria (Ref.). The anticancer mechanism behind Doxycicline is related to it’s impact on mitochondria. The main anticancer mechanisms behind Mebendazole it’s related to interference with microtubule dynamics (Ref.).
The result from Care Oncology Clinic demonstrates that life extension can also be obtained with cheap and available drugs that are accessible to most of the people.
To me, this is just a taste of the value confined in the academic space and waiting to be exposed. And it hits at the core of my goal: exposing valuable discoveries from academic world that can be fast implemented to improve and extend life of cancer patients.
Due to reasons discussed here, to the above cocktail I would also add the following:
- Dypiridamole 200mg 2x/day
- HCA 2-3g/day
- Bioperine 30mg/day
- Aspirin 100mg/day