First, I will start this post by wishing all the readers a Happy New Year full of health for you and your family, and a lot of success in everything you do! I also like to specifically thank to Ann who was the first visitor/friend this year to post a wish to all of us on this website.
Dichloroacetate (DCA), is probably one of the first anti cancer drugs I came across when starting to search for new effective drugs that can help fight cancer. After all these years, I believe even more in the potential behind DCA. This is because, I do know personally two people/friends who benefited from DCA treatment and are alive today due to DCA. And they used no other major treatments such as chemo. One of them is a man diagnosed >10 years ago with stage IV colon cancer and the other is a man diagnosed >5 years ago with stage IV lung cancer. And both of them are alive today.
It is true, after about >5 years their cancer came back and they succeeded to manage that with various elements including 3BP. Below I also intend to shortly discuss the mechanism through which some cancers responding may become resistant to DCA and possible routes to overcome that.
DCA has been extensively discussed, investigated and used in both alternative cancer treatment and academic world. With this post, I do not intend to consolidate all the extensive research on DCA. Instead, I will make a short summary with the most relevant points I am aware of and that need to be considered when DCA is used as an anti cancer treatment. Next to this post, a lot of relevant discussions on the use of DCA can be found at the following website: http://www.thedcasite.com
DCA is a white powder, the salt version of Dichloroacetic acid. Outside the oncology field, DCA is a drug known for many decades that has been considered for treatment of lactic acidosis. (Ref.1, Ref.2) DCA as an anti-diabetic and lipid-lowering drug (Ref), with potential for treating these conditions as well as myocardial and cerebrovascular ischemia (Ref.).
While known for long time, the potential of DCA in oncology has only recently begun to receive attention after major publications from the University of Alberta, Edmonton, Canada where the scientists were concluding the following: “Here, we review the scientific and clinical rationale supporting the rapid translation of this promising metabolic modulator in early-phase cancer clinical trials.” (Ref.1, Ref.2), scientific publications that until today are cited by >100 other scientific publications. An explosion of press coverage followed that: https://www.youtube.com/watch?v=oq-oT8-2tC8; https://www.youtube.com/watch?v=8nTg53izwpE; https://www.youtube.com/watch?v=oq-oT8-2tC8; and so on …
Due to its mechanism of action DCA may be relevant to most types of cancers, including:
- breast cancer (Ref.1, Ref.2, Ref.3)
- colon and colorectal cancer (Ref.1, Ref.2)
- prostate cancer (Ref.)
- acute myeloid leukemia (Ref.)
- oral squamous cell carcinoma (Ref.)
- glioblastoma (Ref.)
- Ovarian cancer (Ref.)
- Neuroblastoma (Ref.)
- Lung cancer (Ref.)
- Non-Hodgkin’s Follicular Lymphoma (Ref.)
- and most of the other cancers …
But in my view it should not be used with cancers that are strongly relying on mitochondria function, such as:
Other positive effects:
- reduces pain in cancer (due to acidity lowering effects) (Ref.)
- reduced massive ascites in 50% of the patients without adjuvant chemotherapy (Ref.)
- could be effective in treating pulmonary arterial hypertension (PAH) (Ref.)
That next to the fact that is a low cost, low side effects and accessible to all people, makes DCA one of the drugs that can be tried by all cancer patients.
Even more, due to its mechanism of action, DCA supports chemotheraphy and radiotheraphy (increases Reactive Oxygen Species in cancer cells and reduces acidity around the tumors) (Ref.1, Ref.2). And even more, because the acidity around the tumor is reduced, the immune system can increase its activity in those specific areas.
But as you will see if you read the rest of this post, there are some more tricks that we need to use in order to increase the chance of DCA for effectiveness against cancer.
More case reports and anecdotal stories can be found here https://medicorcancer.com/new-dca-publication-world-first/
Case reports in humans:
Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapy. https://www.ncbi.nlm.nih.gov/pubmed/27803917
A case is presented in which oral DCA therapy resulted in tumour stabilization of stage 4 colon cancer in a 57 years old female for a period of nearly 4 years, with no serious toxicity. Since the natural history of stage 4 colon cancer consists of steady progression leading to disability and death, this case highlights a novel use of DCA as a cytostatic agent with a potential to maintain long-term stability of advanced-stage cancer.
A Novel Form of Dichloroacetate Therapy for Patients With Advanced Cancer: A Report of 3 Cases http://alternative-therapies.com/at/web_pdfs/s202khan.pdf
Oral dichloroacetate sodium (DCA) is currently under investigation as a single agent and as an adjuvant for treatment of various cancers. One of the factors limiting its clinical use in a continuous oral regimen is a doserelated, reversible neurotoxicity, including peripheral neuropathy and encephalopathy. The intravenous (IV) route has a number of potential advantages, including (1) pulsed dosing to achieve higher concentrations than feasible with oral use, (2) a longer washout period to reduce the potential for neurotoxicity, and (3) a bypassing of the digestive system, which is particularly significant for advanced-stage cancer patients. Data were available on high-dose IV DCA (up to 100 mg/kg/dose) that have confirmed its safety, both in healthy volunteers and in critically ill patients, allowing the authors to begin offlabel treatment of cancer patients. In several of their patients treated with IV DCA, the authors observed clinical, hematological, or radiological responses. This article presents 3 cases with patients who had recurrent cancers and for whom all conventional therapies had failed: (1) a 79-y-old male patient with colon cancer who had liver metastases, (2) a 43-y-old male patient with angiosarcoma who had pancreatic and bone metastases, and (3) a 10-y-old male patient with pancreatic neuroendocrine carcinoma who had liver metastases.
Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report. http://www.ncbi.nlm.nih.gov/pubmed/22580646?dopt=Abstract&holding=npg
DCA combined with OPZ and TAM exhibited more potent antitumor activity than DCA alone in HT1080 fibrosarcoma cells, but did not influence proliferation of WI-38 human fibroblasts. All these drugs induce caspase-dependent cell growth inhibition through superoxide production. Since they can be taken orally and have been used clinically without major side effects, it was thought that this combination therapy would be a readily translated strategy to treat malignant tumors. Under the patient’s consent these three drugs were prescribed to a 51-year old female cholangiocarcinoma patient to whom neither gemcitabine+S-1 nor adoptive immunotherapy with natural killer cells was effective. Disease progression was successfully blocked (the rise of serum CA19-9 value) for three months, also confirmed by CT.
Non-Hodgkin’s Lymphoma Reversal with Dichloroacetate https://www.hindawi.com/journals/jo/2010/414726/
In June 2007, a 48-year-old male patient, diagnosed with Stage 4 Non-Hodgkin’s Follicular Lymphoma (NHL), was treated for 3 months with conventional chemotherapy resulting in a complete remission. Almost one year later tumors returned in the nasopharynx and neck lymph glands. Refusing all suggested chemotherapies, the patient began self-administering dichloroacetate (DCA) 900 mg daily with a PET scan showing complete remission four months later. Since his last PET scan, May, 2009, he remains tumor-free from continuous DCA usage.
Prolonged Survival After Dichloroacetate Treatment of Non-Small-Cell Lung Carcinoma-Related Leptomeningeal Carcinomatosis http://www.journalmc.org/index.php/JMC/article/view/2456/1816
Here we present an observational case report of a 49-year-old female, non-smoker, having a poor performance status with non-small-cell lung cancer and leptomeningeal carcinomatosis (LMC), who upon introduction of oral dichloroacetate (DCA) survived approximately 64 weeks (454 days) following palliative whole brain radiation without the need for chemotherapy or further targeted therapy to specifically address the LMC. To our knowledge, this is the first case report incorporating the use of DCA in LMC. Our findings are discussed in the context of previously reported applications of DCA in malignancies of the central nervous system.
Long-term stabilization of metastatic melanoma with sodium dichloroacetate https://medicorcancer.com/wp-content/uploads/DCA-Melanoma-4-Yrs-Remission.pdf
Sodium dichloroacetate (DCA) has been studied as a metabolic cancer therapy since 2007, based on a publication from Bonnet et al demonstrating that DCA can induce apoptosis (programmed cell death) in human breast, lung and brain cancer cells. Classically, the response of cancer to a medical therapy in human research is measured by Response Evaluation Criterial for Solid Tumours definitions, which define “response” by the degree of tumour reduction, or tumour disappearance on imaging, however disease stabilization is also a beneficial clinical outcome. It has been shown that DCA can function as a cytostatic agent in vitro and in vivo, without causing apoptosis. A case of a 32-year-old male is presented in which DCA therapy, with no concurrent conventional therapy, resulted in regression and stabilization of recurrent metastatic melanoma for over 4 years’ duration, with trivial side effects. This case demonstrates that DCA can be used to reduce disease volume and maintain longterm stability in patients with advanced melanoma.
More case reports and anecdotal stories can be found here https://medicorcancer.com/new-dca-publication-world-first/
and in the comments section here https://blogs.sciencemag.org/pipeline/archives/2010/05/14/dca_and_cancer_more_results
For those familiar with the cellular metabolism, the mechanism behind DCA’s anti cancer effect is relatively straight forward. At least the main one as we understand today. Here is in a few words how DCA works:
Source photo: (Ref.)
- Pyruvate dehydrogenase (PDH), is a complex of enzymes that converts cytosolic pyruvate to mitochondrial acetyl-CoA, the substrate for the Krebs’ cycle.
- However, in most cancers, another enzyme called Pyruvate dehydrogenase kinase (PDK) (a mitochondrial enzyme) is activated and results in the selective inhibition of PDH.
- As a result, instead of entering mitochondria, because PDH is inhibited, pyruvate can not go in so that it goes further down the glycolisis (fermentation) pathway and is finally converted in lactic acid
- DCA has the potential to inhibit PDK, so that PDH can function again
- When PDH works, pyruvate can be processed by mitochondria, so that the cell engine produces again energy (ATP) in a normal way and not via fermentation
- When mitochondria works it produces Reactive Oxygen Species (ROS) as well. And it is known that high levels of ROS (such as H2O2) can inhibit tumor growth and result in apoptosis.
- This is also the reason why, DCA helps chemo and radio therapy, since both of these treatment routes lead to increase of ROS. Normally, cancer cells produce a high level of anto oxidants to cope with the intracellular ROS, but once the ROS levell is to high (due to e.g. chemo and/or DCA) tumor cells will be killed.
Here are more details on how DCA works: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567082/
Indeed, it has been shown that Dichloroacetate treatment improves mitochondrial metabolism, and the pyruvate dehydrogenase activity and the amount of acetyl-CoA in mitochondria was significantly higher after DCA treatment (Ref.)
It has also been shown that DCA induces autophagy in cancer cells accompanied by ROS production and mTOR inhibition, reduced lactate excretion, reduced k(PL) and increased NAD(+)/NADH ratio. The observed cellular and metabolic changes recover on cessation of treatment. (Ref.)
B1 vitamin and Alpha Lipoic Acid may act against cancer via similar mechanism as Dichloroacetate (Ref.1, Ref.2). However, I would not combine ALA with DCA. At least not in the IV form. Please read this comment to understand why https://www.cancertreatmentsresearch.com/dichloroacetate-dca-treatment-strategy/#comment-4502
As discussed shortly above cancer cells may become resistant to DCA. Two of the major reasons for resistance (and how to address them) are discussed in the next section below. Another reason for Resistance suggested by some of the most relevant scientist in the field may be the fact that in time, due to increase alkalinity of cancer cell, mitochondria may become totally dysfunctional or non-existent, in which case no matter how much DCA we would use, there will be no way for it to work (Ref: private communications).
Even when DCA can not effectively activate oxidative respiration via the mechanism described above, it may be able to kill cancer cells via a different mechanism that leads to accumulation inside the cytoplasm of high levels of citrate which in turn leads to the inhibition of glycolysis and inactivation of P-glycoprotein (Ref.). Inactivation of P-glycoprotein means that the cancer cells will not be able to push out chemotherapy and as a result, this also means that DCA can nicely support chemotherapy. Having this mechanism in mind, we can also argue that DCA theraphy works hand in hand with the Citric Acid therapy I discussed in another post: Citric Acid
Update January 2020: Intrestingly, DCA reduces blood glucose via reduction of gluconeogenesis https://www.ncbi.nlm.nih.gov/pubmed/8656614 This is a very interesting anticancer activity due to the reason discussed here.
Note: Phenylbutyrate drug may also do a similar job as DCA: Phenylbutyrate May Be Repurposed to Treat Lactic Acidosis https://www.medscape.com/viewarticle/780374
DCA prior to chemotherapy can enhance chemo effectiveness
A scientific article recently (end 2018) published in one of the most prestigious journals (Nature), demonstrated that DCA has the capability to improve chemo effectiveness by inhibiting the multi drug resistance (MDR) pumps used by cancer cells to push out chemotherapy from the cell and thus resist therapies (Ref.). This is very interesting capability of DCA, unknown to the world so far, and it explains why one of the visitor of this website (Emad) succeeded to regain effectiveness of chemo given to his mom when he used DCA prior to the chemo cycle.
How to increase the chance DCA will do its job? This is the most interesting part of the post to me.
Transport of DCA inside the cancer cells is essential … and not always there:
Dichloroacetate-induced apoptosis in cancer cells requires sodium-coupled monocarboxylates transporter SLC5A8 (SMCT1). If the transporter is not expressed, cells may not accumulate the compound to levels sufficient enough to cause apoptosis. (Ref.)
Note that SMCT1 is the same transporter that is required for the anti-cancer effects of Butyrate supplements or Pyruvate.
However, SMCT1 it is epigenetically silenced in most tumour cells (Ref.), which could explain why high DCA concentrations should be used to achieve cytotoxicity in cancer cells. So, this is the reason why DCA doesn’t work for all cancers or if it works it is required at a high dose.
So the question is, how to reactivate SLC5A8 when that is inactive? Inhibitors of DNA methylation induce reactivation of SLC5A8. (Ref.) This means we need Inhibitors of DNA methylation. Fortunately, procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. (Ref.) This is great, since procaine is accessible (easy to find in German pharmacies), cheap and safe. Procaine is used in alternative cancer treatment clinics in combination with Natrium Bicarbonate IVs and is also the main component in the well known anti aging drug Gerovital.
Now it becomes very interesting to me. I just found this paper stating the following “Knowledge on the regulation of SMCT1 at the intestinal level is very scarce. SMCT1 has been found to be inhibited by some NSAIDs (ibuprofen, ketoprofen, fenoprofen, naproxen and indomethacin), phytochemicals (resveratrol and quercetin), TNF-α, oxidative stress, chenodeoxycholic acid and by the absence of gut commensal bacteria. On the contrary, SMCT1 was found to be stimulated by some other NSAIDs (diclofenac, meclofenamate and sulindac), by activin A and by the probiotic Lactobacillus plantarum.” (Ref.)
Why is this so interesting to me? That is because the paper indicates that Diclofenac increases SMCT1 … and here is a funny story: My friend, stage IV cancer patient that saw his lung cancer gone when using DCA, once said to me that long time ago he had so much pain from his cancer … but he did not wanted to take Morphine. Instead, he used a lot of Diclofenac. I remember he said he took so much Diclofenac every day, like candies. And this was probably the key for such a good response to DCA he had. Unfortunately, not everyone can take a lot of Diclofenac due to the side effects related to the stomach, known to be characteristic to NSAIDs.
As you can see from above, Quercetin, Resveratrol and Ibuprofen should be avoided while on DCA.
It has been previously shown that Sulindac can indeed support DCA treatment, but the mechanism was explained in a different way (Ref.). However, possibly the main reason for the synergy between the two is actually explained above.
Not only transporters but also GSTZ1 expression and chloride concentrations are relevant for DCA effectivness:
Here is a paper published in 2016 that I find very relevant for understanding how to further improve DCA effectivness: “GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate” (Ref.). This paper indicates the following.
- DCA is metabolized in the liver by the glutathione transferase zeta 1 enzyme (GSTZ1)
- During metabolism of DCA, a portion of the GSTZ1 can be irreversibly inhibited by DCA
slowing the clearance of subsequent doses of DCA
- However, chloride anions can inhibit DCA-induced GSTZ1 inactivation
- Some cancer cells (such as in breast cancer) over express GSTZ1 and confer resistance to the anti cancer effects of DCA
- In addition in tumors chloride anions level is often abnormally high compared to the surrounding tissue
- On this line, if the tumor expresses GSTZ1 and contains a high chloride anions level, the GSTZ1 will be stable, maintaining the resistance to DCA
- As a result, co-treatment with compounds to reduce GSTZ1 expression or chloride anions level will reduce the resistance to DCA
This means that now we are in search for GSTZ1 an/or chloride anion trasnport inhibitors. Here are a few of those:
- Etacrynic acid is a Cl(-)-ATPase inhibitor http://www.ncbi.nlm.nih.gov/pubmed/1839837
- Lansoprazole and Omeprazole inhibit chloride channels http://www.ncbi.nlm.nih.gov/pubmed/10711360
- Chlorotoxin found in scorpion venom (see my post on scorpion venom) can also inhibit chlorine channels https://en.wikipedia.org/wiki/Chlorotoxin
- Metformin also inhibits Cl channels: Metformin impairs the chloride current directly interacting with the extracellular portion of CLIC1 (chloride intracellular channel 1 – a transiently active channel essential for GBM growth). http://www.impactjournals.com/oncotarget/index.php?
Well, now I understand why previous studies have shown synergy between DCA and Omeprazole (Ref.1, Ref.2). But this mechanism was not known in those studies.
On the other hand Bromide, iodide and sulfite also protected GSTZ1 from inactivation by DCA (Ref.). So we want to avoid them. Same counts for Quercetin that may increase chloride anion level in the cytosol (Ref.). Thus, while Quercetin has its own anti cancer effects, when using DCA is good to avoid its use.
Safety and Toxicity:
DCA can cause a reversible peripheral neuropathy that may be related to thiamine deficiency and may be ameliorated or prevented with thiamine supplementation. This is the main potential side effect.
In the majority of patients using it, DCA is well tolerated. Side effects are mild but can include fatigue, confusion, memory loss, sedation, tremors, hallucination, agitation, depression, heartburn (oral), and nausea (oral) (Ref.)
DCA is metabolized in the liver and as a result caution is required when administering DCA in cases of compromised liver function.
Absorbed in the gastrointestinal tract and less than 1% of the total given dose is excreted in the urine; Metabolism of DCA occurs in the liver; DCA inhibits its own metabolism resulting in slower clearance from the body after multiple doses, which increases the potential for toxic effects; Although the halflife with the initial dose is less than one hour, this half-life increases to several hours with successive doses. There appears to be a plateau of this effect and DCA serum levels do not continue to rise with ongoing use (Ref.).
- Start with 10mg/kg/day and increase slowly to about 25mg/kg/day (others are going to higher doses but I prefer safety instead – 25mg/kg/day is well tolerated (Ref.)). If neurophathy is emerging, reduce the dose slightly to below that level where it occurred. Here you can calculate the dosage depending on your weight http://www.thedcasite.com/dca_dosage.html
- Use half of the dose in the morning and half in the evening
- To avoid neurophathy use DCA during 5days/week and stop for the other two (others are using 2 weeks ON and one week OFF scheme)
Update 12-March-2017: According to this article (Ref.) it is best to use the two weeks On and one week off scheme.
- Use DCA until no evidence of disease
- Preferably to drink by mixing the powder from capsule in water: https://www.youtube.com/watch?v=EbLqAFD7HaI. This is for better absorption.
- Up to 100mg/kg can be well tolerated (Ref.) I would however never jump to that high dose and start from 20mg/kg and best stop around max 70mg/kg max (Ref.). We used this dose with no issues but others may react differently.
- Injected in 250ml NaCl bag, administered during 45 to 60 min
- Administered 2x/week
DCA effect is dose dependent but there is a saturation level beyond which increasing the dose has no extra benefit (Ref.).
Additions to increase effectiveness or address potential side effects:
- Caffeine: anecdotally, caffeine would increase effectiveness – I do not understand the mechanism behind this other than improving the micro vessel circulation
- B1 Vitamine (thiamine) to reduce chance for neurophaty – some take 500mg/day, others up to 2500mg/day (Ref.). In addition B1 vitamin has its own anti cancer effect similar to that of DCA (Ref.1)
- Procaine, Diclofenac or Sulindac to increase SMCT1 (see above)
- Omeprazole 80mg/day to increase DCA effectiveness (see above)
- Scorpion venom to increase DCA effectiveness (see above)
- Metformin 1000mg to 1500mg/day (see above)
- Propranolol (Ref.)
- Fenbendazole shows strong synergy when combined to DCA (Ref.). So it may make very much sense to combine the two.
Note: DCA is not tumor cell specific, and therefore the same shift in glucose metabolism that occurs in cancer cells will also take place in immune cells, leading to induction of Tregs (Ref.). In order to avoid this possibility, while using DCA I would also use Treg inhibitors such as Cimetidine (Ref.) or low dose Cyclophosphamide (Ref.).
Buyers should be aware that some companies may be selling fake DCA. One owner of a web-based company has already been convicted of internet fraud for selling counterfeit DCA http://www.cbc.ca/news/story/2010/06/01/con-dca-gaber.html As a result take care where you are ordering your DCA. One reader of this website (Emad) seeing positive results with his mom while using DCA and chemo wrote the following: “I tried this www.puredca.com, and this www.dcalab.com but the best results i had is when using this one www.dcacancer.org“.
IV form can be purchased from compounding pharmacies such as those listed here https://www.cancertreatmentsresearch.com/?page_id=945. However, it may be too expensive compared to the self made version. Because DCA is water soluble it can be easily prepared in IV form in the same way as 3BP (see 3BP IV section here https://www.cancertreatmentsresearch.com/?p=47). Depending on the dose used, self made version will cost <10 euro / dose.
Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate. https://www.ncbi.nlm.nih.gov/pubmed/?term=SLC5A8+dca
There has been growing interest among the public and scientists in dichloroacetate (DCA) as a potential anticancer drug. Credible evidence exists for the antitumor activity of this compound, but high concentrations are needed for significant therapeutic effect. Unfortunately, these high concentrations produce detrimental side effects involving the nervous system, thereby precluding its use for cancer treatment. The mechanistic basis of the compound’s antitumor activity is its ability to activate the pyruvate dehydrogenase complex through inhibition of pyruvate dehydrogenase kinase. As the compound inhibits the kinase at micromolar concentrations, it is not known why therapeutically prohibitive high doses are needed for suppression of tumor growth. We hypothesized that lack of effective mechanisms for the entry of DCA into tumor cells may underlie this phenomenon. Here we show that SLC5A8 transports DCA very effectively with high affinity. This transporter is expressed in normal cells, but expression is silenced in tumor cells by epigenetic mechanisms. The lack of the transporter makes tumor cells resistant to the antitumor activity of DCA. However, if the transporter is expressed in tumor cells ectopically, the cells become sensitive to the drug at low concentrations. This is evident in breast cancer cells, colon cancer cells and prostate cancer cells. Normal cells, which constitutively express the transporter, are however not affected by the compound, indicating tumor cell-selective therapeutic activity. The mechanism of the compound’s antitumor activity still remains its ability to inhibit pyruvate dehydrogenase kinase and force mitochondrial oxidation of pyruvate. As silencing of SLC5A8 in tumors involves DNA methylation and its expression can be induced by treatment with DNA methylation inhibitors, our findings suggest that combining DCA with a DNA methylation inhibitor would offer a means to reduce the doses of DCA to avoid detrimental effects associated with high doses but without compromising antitumor activity.
A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. http://www.ncbi.nlm.nih.gov/pubmed/17222789
The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted. Compared to normal cells, several human cancers have high mitochondrial membrane potential (DeltaPsim) and low expression of the K+ channel Kv1.5, both contributing to apoptosis resistance. Dichloroacetate (DCA) inhibits mitochondrial pyruvate dehydrogenase kinase (PDK), shifts metabolism from glycolysis to glucose oxidation, decreases DeltaPsim, increases mitochondrial H2O2, and activates Kv channels in all cancer, but not normal, cells; DCA upregulates Kv1.5 by an NFAT1-dependent mechanism. DCA induces apoptosis, decreases proliferation, and inhibits tumor growth, without apparent toxicity. Molecular inhibition of PDK2 by siRNA mimics DCA. The mitochondria-NFAT-Kv axis and PDK are important therapeutic targets in cancer; the orally available DCA is a promising selective anticancer agent.
Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate http://link.springer.com/article/10.1007/s10545-014-9808-2/fulltext.html
Pyruvate dehydrogenase complex (PDHC) is a key enzyme in metabolism linking glycolysis to tricarboxylic acid cycle and its activity is tightly regulated by phosphorylation catalyzed by four pyruvate dehydrogenase kinase (PDK) isoforms. PDKs are pharmacological targets for several human diseases including cancer, diabetes, obesity, heart failure, and inherited PDHC deficiency. We investigated the inhibitory activity of phenylbutyrate toward PDKs and found that PDK isoforms 1-to-3 are inhibited whereas PDK4 is unaffected. Moreover, docking studies revealed putative binding sites of phenylbutyrate on PDK2 and 3 that are located on different sites compared to dichloroacetate (DCA), a previously known PDK inhibitor. Based on these findings, we showed both in cells and in mice that phenylbutyrate combined to DCA results in greater increase of PDHC activity compared to each drug alone. These results suggest that therapeutic efficacy can be enhanced by combination of drugs increasing PDHC enzyme activity.
Metabolic plasticity in cancer cells : involvement in the processes of proliferation and response to radiotherapy http://dial.uclouvain.be/handle/boreal:171100 http://dial.uclouvain.be/downloader/downloader.php?pid=boreal:171100&datastream=PDF_01
While pioneering studies suggested that enhanced glycolysis, a hallmark of cancer, was caused by an irreversible impairment in mitochondrial respiration, more recent data reported functional mitochondrial activity in many cancer cells. In this thesis, we thus intended to investigate whether metabolic modulations could improve the therapeutic outcome of cancer. We found that dichloroacetate, a new clinically tested compound, induced a switch of glycolytic cancer cells to a more oxidative phenotype, and decreased tumor cell proliferation through a decrease in the activity of the pentose phosphate pathway. In a second part of this work, we investigated whether targeting mitochondrial respiration with H2S, the last gaseous transmitter identified in mammals, improved tumor response to radiotherapy. By rapidly alleviating hypoxia inside solid tumors, the single injection of a H2S donor increased the radioresponse of cancer in mice. Overall, our thesis work emphasizes the ability of cancer cells to remodel their energetic metabolism in response to external stimuli and supports that both glycolysis and oxidative phosphorylation are attractive targets for cancer therapy.
Metabolic Modulation of Glioblastoma with Dichloroacetate http://stm.sciencemag.org/content/2/31/31ra34.abstract
Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis. This metabolic remodeling is accompanied by mitochondrial hyperpolarization. We tested whether the small-molecule and orphan drug dichloroacetate (DCA) can reverse this cancer-specific metabolic and mitochondrial remodeling in glioblastoma. Freshly isolated glioblastomas from 49 patients showed mitochondrial hyperpolarization, which was rapidly reversed by DCA. In a separate experiment with five patients who had glioblastoma, we prospectively secured baseline and serial tumor tissue, developed patient-specific cell lines of glioblastoma and putative glioblastoma stem cells (CD133+, nestin+ cells), and treated each patient with oral DCA for up to 15 months. DCA depolarized mitochondria, increased mitochondrial reactive oxygen species, and induced apoptosis in GBM cells, as well as in putative GBM stem cells, both in vitro and in vivo. DCA therapy also inhibited the hypoxia-inducible factor–1α, promoted p53 activation, and suppressed angiogenesis both in vivo and in vitro. The dose-limiting toxicity was a dose-dependent, reversible peripheral neuropathy, and there was no hematologic, hepatic, renal, or cardiac toxicity. Indications of clinical efficacy were present at a dose that did not cause peripheral neuropathy and at serum concentrations of DCA sufficient to inhibit the target enzyme of DCA, pyruvate dehydrogenase kinase II, which was highly expressed in all glioblastomas. Metabolic modulation may be a viable therapeutic approach in the treatment of glioblastoma.
Dichloroacetate and cancer: New home for an orphan drug? http://www.ncbi.nlm.nih.gov/pubmed/25157892
We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and congenital disorders of mitochondrial intermediary metabolism. Inhibition by DCA of mitochondrial pyruvate dehydrogenase kinases and subsequent reactivation of the pyruvate dehydrogenase complex and oxidative phosphorylation is the common mechanism accounting for the drug’s anti-neoplastic effects. At least two fundamental changes in tumor metabolism are induced by DCA that antagonize tumor growth, metastases and survival: the first is the redirection of glucose metabolism from glycolysis to oxidation (reversal of the Warburg effect), leading to inhibition of proliferation and induction of caspase-mediated apoptosis. These effects have been replicated in both human cancer cell lines and in tumor implants of diverse germ line origin. The second fundamental change is the oxidative removal of lactate, via pyruvate, and the co-incident buffering of hydrogen ions by dehydrogenases located in the mitochondrial matrix. Preclinical studies demonstrate that DCA has additive or synergistic effects when used in combination with standard agents designed to modify tumor oxidative stress, vascular remodeling, DNA integrity or immunity. These findings and limited clinical results suggest that potentially fruitful areas for additional clinical trials include 1) adult and pediatric high grade astrocytomas; 2) BRAF-mutant cancers, such as melanoma, perhaps combined with other pro-oxidants; 3) in which resistance to standard platinum-class drugs alone may be overcome with combination therapy; and 4) tumors of endodermal origin, in which extensive experimental research has demonstrated significant anti-proliferative, pro-apoptotic effects of DCA, leading to improved host survival.
Sensitization of breast cancer cells to paclitaxel by dichloroacetate through inhibiting autophagy http://www.sciencedirect.com/science/article/pii/S0006291X17309786
Chemotherapy is still the main adjuvant strategy in the treatment of cancer, however, chemoresistance is also frequently encountered. Autophagy inhibition has been widely accepted as a promising therapeutic strategy in cancer, while the lack of effective and specific autophagy inhibitors hinders its application. Here we found that dichloroacetate (DCA), a small molecule compound, could significantly inhibit the autophagy induced by Doxorubicin in breast cancer cells. And DCA markedly enhances Doxorubicin-induced breast cancer cell death and anti-proliferation in vitro. But the sensitization to Dox of DCA was significantly reduced through induction of autophagy by rapamycin. Moreover, the combined therapy of Dox and DCA could significantly inhibit tumor growth in vivo and prolong mouse survival time. Taken together, we demonstrate that DCA could inhibit doxorubicin-inducing autophagy and provide a novel strategy for improving the anti-cancer efficacy of chemotherapy.
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476 thoughts on “Dichloroacetate (DCA): An Accessible Drug to Fight Cancer”
Great work,perfect work.Thank you very much for all of us.
If you wish i can begin to write here our treatments after DCA alone(shortly).
As i can see we are only 3-5 people using DCA ,we need to attract more peoples attention to learn from their experiences
and to help others.
May be we can find a good combination treatment with DCA in one day.
You can make that 6!
Hi Jason welcome,
I hope you have good news about DCA.
Thank you for your once again great article.
As mentioned above ALA plus vit B1 have the same effect as DCA.
As DCA has to wait because of liver that doesnt work to good, ALA helps regenerate liver so is perfect for us.
I use flaxseed oil in Budwig ‘s pap. Flaxseed has a lot of ALA. Or it has to be in pills.
I wonder about doses.
You are very welcome! I would use all but I understand the liver challenges.
Regarding ALA I am not sure how much is found in flaxseed oil but here I wrote some time ago on the ALA dose: https://www.cancertreatmentsresearch.com/?p=956
How do you use ALA?
I have to search for it.Could you please write your experiences shortly about it?
Did you try DCA before?If yes did you see some good results with ALA or DCA?
While waiting for the response from Anna, here is a response from my side: ALA will be given orally or IV. During chemo I would not use it IV because it is too strong anti oxidant and will help cancer cells survive, unless liver is in a very bad shape in which case you need to use ALA IV.
Btw, Anna, I do not remember if you already mentioned that: for liver are you using Hepa Merz IV or orally? Example of oral version http://www.eurapon.de/hepa-merz-granulat-3-000-beutel-07620639/?utm_source=medizinfuchs.de&utm_medium=preissuchmaschine&utm_campaign=medizinfuchs
She didnot use ALA yet also we didnt give cafeine.
Only Thiamine 500mg x2.We are still on DCA 600mgx1.
Should we give those?,ii dont have any idea.
To me, from the point of view of supporting DCA, the others are more important such as Omeprazole and Metformin (see the reasoning in the post above). I would use ALA mainly for liver support, oral form.
We use Hepa Merz in sachets, but up to now I didn’t really understand if it is really neceassary to use and it is very expensive. It is used only to remove ammonia but I am not sure it regenerates liver.
hi Ergin and of course hi everyone,
Sorry for so long time to answer but I had technical problems to answer. I wrote a post and couldn’t post it. Now I am back at home so I hope I will not have problems to post.
Unfortunately I can not share too much because I estime my experience is very poor.
I used few things but there wasn’t nothing which really worked 🙁 .
I also found thus page just before my husband started to have problems with liver after SIRT so a lot of therpaies are not for us because all of them are toxic to liver.
I purchased ALA quite long time ago when my husband had problems with neuropthy, but we never really used it in big doses. It also didn’t really help.
But when I asked Daniel what does he recommends for liver, his answer was sylimarol, Hepa merz and ALA and i think armetisin.
Sylimarol we take already more than two years, to help liver when on chemo. But initially dose was quite low 140 mg, now we take around 700 mg per day.
And ALA, we finished the package and I was wondering to order a new one this time RLA as more potent than ALA. But every winter I order from producer in Germany real cold pressed flax oil. I order it only in winter when transport can be done in low temperatures. This oil must be kept under 10 degress, no light, and its validity is only 2 months.
I use it to prepare a budwig pap it is mix of cottage cheese and flax seed in proprtion 1 spoon of oil with two spoons of cottage cheese. I usually use 6 spoons oil and 12 spoons cheese and mix it on slow motion mixer for three minutes. After it is well mixed I add banana and beriies and sometime freshly ground flax seeds.
We use it mainly for omega 3 reasons but after post of Daniel I learned it is also full of ALA, and I believe it could be beter than pills.
When we used it together with chemo last year chemo did good work. This summer there was no Budwig pap and chemo didn’t work. So maybe there was something in it.
So it is my experience, not really valuable but I believe budwig diet is surely not bad. Just my husband as a big meat eater cannot stick to all other points of this diet.
The other issue is borage oil, I add it also to juices or sometimes to budwig pap, it is full of GLA, works also anti inflammatry, reduces prostaglandine E2 which cancer use to grow. GLa is also in spiruline.
No ergin, no DCA up to now.
One box is waiting for its time but for the moment too toxic for liver.
ALA was also not in so big doses to see effects I believe.
I have to say my husband is very difficult to take all supplements I ask him. It is always a fight and I cannot control him if when Ia ma at work he takes it or just throw it away.
Thank you very much for your message.
I hope everything will be fine for him.
Are you trying DCA, B1? ALA?
Are you trying Budwick?
How are things? I hope something is working.
Ann you might be thinking of the Omega-3 oil alpha-linolenic acid (ala), which is in flaxseed in abundance not alpha lipoic acid, the ALA Daniel is referring to in this article.
I have found 2 different cases, they use both DCA and ammonium tetrathiomolybdate for controlling copper deficiency.
Do you have any experience with those 2 combinations.?Especially for ammonium tetrathiomolybdate(TM).
In one case it works alone without DCA!!!
Thank you for the links. There are many reports on DCA indeed.
DCA and TM should work well and TM is a nice one as an angio genesis inhibitor. I wrote an article on it sometime ago https://www.cancertreatmentsresearch.com/?p=249
I had the same response to DCA as that first case. I had an excellent response during the first month but then DCA became ineffective. I stopped DCA for one year and decided to try again as my diseases was becoming more aggressive. Once I again I experienced the same, the first 3-4 weeks were incredible but afterwards it stopped having any effect and the diseases started to spread again.
Do you know of other similar experiences? Is there any way to overcome that?
Thank you Daniel for this great article on DCA
I noticed a lot of information that I was not aware of , especially about how to make DCA work better if the resistant happened
yesterday the tumor marker results shows a little decline , from 381 to 353 , I was using DCA and chemo
also the DCA version that I was using shows a little effect , of course I returned to use the old DCA from dcacancer.org , that is the one that I used to have a very good results with it , but also maybe I’m wrong and the DCA started to be ineffective
anyway , I should return to Salinomycin quickly as before , I should receive it soon , also , my mother will have a PET Scan tomorrow
we hope to see a good results
i wish a happy healthy new year to you all Daniel , Ann , Ergin , Pouya and all the other friends and cancer fighters around the world
Thank you Emad for the update and kind words. I wish you and your mom a happy and healthy new year too!
Thank you Emad,
I also wish you a happy new year.
I wonder do you use TM or Thalomide or another angiogenesis inhibitor with DCA?
Sorry for late update.I was travelling.
We took the blood count results on saturday .
CA125 rised from 21 to 28 in 15 day with DCA alone 600 mg/day.
We began 600×2 mg/day on saturday and waiting for the results.
Last results on DCA :
CA125 stopped rising and declined to 27,after 4 days with 23mg/kg/day.
Hi Ergin , I hope you have better and better results in the upcoming days
DCA is dose dependent , I remember when I lowered the dose everything went wrong
today we have done a CT Scan , the bone mets are stable (also became more dens)
and there is moderate regression of the liver mets
that’s the good news
but I’m little concerned about the liver enzymes test
ASAT and ALAT used to be always on the range of 15 to 30
but now they are 45 and 46
also GGT (Gamma glutamyl transferase) and PAL (Phosfatase alcalines) are both normal
is that an indecation about some liver damage , due to cancer or drugs ! I don’t know
but sure I will put my eyes on them , also I don’t want to face other complications that may interfere with our plan
hope things go well for me , you Ergin , Ann and all the others
I dont know where to begin but i have different news today.
I went to a company who sells collodial silver.They are not amateur.
We talked for 2 hours about collodial silver.
He said that use it and forget about cancer.He has lots of good feedback about cancer patients.(80 percent he said).
May be you catch from some of my messages that i am searching for nano silver for months.
He always gave silver to his small daughter when she is ill and never went to a doctor.
But they are seller,i never forget.
In Georgia collodial silver is sold in pharmacies and they use it for their child.
I have read some academic articles that,it is very effective on cancer stem cells especially.
But particle size dependent.
Very safe to use etc..
But we couldnt find a cancer patient here that used it before.I found a woman who suffers from ovarian cancer on internet.
Her ca125 declined very very fast after using it.But i couldnt reach her.
I will wait for 1 week to see the power of DCA and than collodial silver with DCA.
I forgut to write Collodial silver is a good glutathione and copper chelator.
I have to find someone to learn how to use it.
I bought 1 lt for 20 usd. it is for 15 days he said.First keep it under tongue for 8-10 minutes,then drink.
25ml x3/day.If she doesnt have high blood pressure ,use it with MMS.But she has high blood pressure.
But i have to learn more about it before using.
Emad, I’m really glad to hear that your CT scans are good and that you see the improvement on the liver metastases.
Regarding the question about ASAT and ALAT – it’s not that much big of a deal to have 45 and 46. It shows extremely mild
breakage of liver cells, may as well be due reduction of liver metastases and their lysis.
In comparison, people with Acute Hepatitis have 100, 200 or even more of ASAT and ALAT. About one out of ten drugs cause liver toxicity and liver enzymes to rise. You’re probably getting elevated levels because of destruction of liver metastases.
I would advise you to remember one thing – the warning sign of liver toxicity due drugs is 75>. Then you should further consult with your physician about what’s going on and carefuly look at the drugs you’re taking. 45 and 46 is not much, people who do anabolic steroids have more than that in their blood stream.
Maybe there is a link between liver toxicity and the purity of DCA ? Anyone have any ideas ?
Dear Eddie, for the fairness purposes I have removed a link you provided (the link you provided is suggesting a brand as being the best and your location based on IP is exactly same as the HQ of the supplier). Thanks for understanding.
To my knowledge, the major providers of DCA have the DCA pure enough not to represent an issue for the liver (I am referring to the delta between them). If there is anything I would look for specifically is the stability and effectiveness of DCA from various suppliers based on test on cell cultures.
I hate it that such a cheap compound is being sold at ridiculous prices (compared to the production price) and one can not even know which source is reliable or not.
Not everybody can go to Dr Khan ( by the way, i also hate the fact they simply stopped counting their success rate – they explained to me in an email that “they want to focus on patients” instead of numbers. Quite weird reasoning, i dont trust him by now either because of the lack of transparency).
this for their dca treatment – i dont anything about their other treatments..
just to clarify: i trust dr khan’s dca and his good intentions, but i dont believe in a centre that is not measuring the success rate of a given treatment because “they focus on the patients”. i dont imply they dont do their best for a given individual.
thank you so much Eddie
this really makes me feel better and not worried so much
yes also DCA seems to increase the liver enzymes
I was happy after the CT scan but since that time everything went wrong , the markers last time is 607
I don’t know how much it could be increased or changed , hope nothing bad happened
also , tomorrow I’m gonna face my nemesis , its the dark scary horrible adrenaline day
God give me strength
Please all friends has to read.
This shows us the importance of cupper depletion.
How you chelate copper?
And should we then supplement with zinc?
Yes we can deplet copper by TM with dose and time dependent.I am sorry because i wrote in wrong place.
The true adress should be this.
How are you and your husband?Hope everything is fine for you and him.
You said he has to give a break to maraviroc because of travelling and diarrhea,if i true remember.
Have you experienced stg positive or negative?
Is erbitux still working after break?
Hi Ergin , sorry to hear about your challenges , why did you stopped chemo ?
how is your mother ? hope she is fine
for me I can’t relay on DCA or any other treatments alone without chemo , if I stopped chemo I may use something like MG
I wish things go well soon
Thank you very much ,she looks fine and feels fine but we dont know the inside.
Only i can say that she has lots of gas in intestines,i hope thats because of collodial silver NOT from ascites.
Tomorrow is big day.Blood counts…
MG and TM is on the way from Sigma.They said 4-6 weeks to arrive!!!
We are going to begin chemo this week.
Emad,do you have experience about heparin?
And did you use thalidomide or TM or MG?
Hi Ergin, we had no scans or CEA yet done but bilirubin fell down and liver function improves. So I hope it works. I added honokiol now at 1.5 g per day. I want to write soon (with help of Daniel if he agrees )article about honokiol. Looks very promising to me.
I do not know yet date of scans to see if Erbitux and Maraviroc still working good.
Ergin, I saw it is not going good way in your mum case. Do you have any new ideas? Did you consider Maraviroc?
Hi Ann, I do like Honokiol a lot and is on my list to write about, but if you can do that instead, it would be great 🙂
Here it says ,ceruloplasmin levels can be a prognostic value like CA 15,3
there is stg wrong with your web site
What do you mean Ergin? I could not reply to your comments yet as I sick but will do tomorrow as I expect I will be better.
You are one of the most intelligent people in this world.
I always wonder why you keep us some information about cancer treatment.
You wrote lots of things with perfect and long words.
No one can understand what you mean accept me and 3-5 people.
I have entered lots of forums and found you in different names.
Yes you are very clever and now how to fight with cancer
But when you will take the responsibility and tell us the way how to fight with brave words?
Without thinking Disclaimer.
I am very very sorry to write to wrong place.There was 2 pages opened and messages were mixed.
OFCOURSE this was not a message for you.The one who uses silver and not answering to my questions.
If you can erase my message i would be very happy.
Or We could not attract peoples attentions?
Cancer is serious ,am i wrong?
I am going to think like I AM the last person about thinking about a CURE!!
A case report describing toxicity of DCA + artesunate combination in a GBM patient
DCA alone does not worked for us.
CA 125 rised to 45 unfortunately.
Pain on abdomen and bowel movements are not good.
This article might help. It shows DCA in combo with other compounds. It also corroborates what you say about DCA as a standalone. I’ve never been high on DCA on its own.
EGCG as far as I’ve heard, inhibits some pathways to cancer cells using glutamine for gluconeogenesis, and IMO could be useful to use in conjunction with DCA. Also, without question, I would start Metformin along with it.
Thank for the link Meech.
Dear Meech, the article you linked shows that we should not have cafeine with DCA+Metformin, i understand from other sources that cafeine is recomended.
Any opinions anyone?
Caffeine has been a somewhat controversial part of DCA therapy. Some claim it’s dangerous, some claim there’s efficacy, and others claim there’s no effect.
I personally haven’t tried it, and I don’t drink coffee so I’m not sure whatsoever.
hi Meech, i read somewhere you have been on dca for one year. how much do you take per kg? Which source do you trust the most ? does it seem to work for you? cheers, W
As to whether it works for me: I started taking it late March 2016, after being on a regimen of capecitabine + temozolomide for 3 months and nothing else. My liver tumours grew to about 5cm, 3cm, 2 cm, and under 1cm while on the CAPTEM. Other tumours grew a bit too; most notably an external iliac node grew to about 2.4cm
At this point I started Keto + metformin + DCA 25mg/kg and some other natural stuff. I went to Germany for TACE with Prof. Vogl who said I had an amazing response (all liver tumours eliminated). I attribute this partly to DCA and Metformin and the diet.
Tumours have continued to grow and spread under DCA and Metformin, but not as quickly as one would suspect. The big tumour giving me issues is that supraclavicular tumour which grew from 2.4cm to 5.5cm in one year.
My cancer has a Ki-67% value of 80%; meaning quite aggressive. My prognosis was 8-10 months in Dec 2014.
So I guess it is working to a degree but is not enough.
Sorry, the tumour giving me issues is the external iliac node, not supraclavicular. I have also increased the dose to 31mg/kg as of a month ago.
My source is Dr. Akbar Khan from Medicor as we are in close proximity to each other.
I have mild neuropathy I would say. If I keep my arm in a particular position for too long, it’ll numb. But in general, nothing really.
much (meech) respect to you, Meech.
what did you receive via TACE? did your cancer start in your liver?
how about adding some light chemo; ldn, chloroquine, mebendazole, cimetidine etc to keto, metformin and supplements?
and of course ala+ hca if that is not already taken by you
TACE was performed with 9.85mg Mitomycin C, 994.98mg Gemzar, 50.94mg Cisplatin. I believe I had 6 sessions to the liver, followed by 2 sessions of microwave ablation to eliminate the residual disease.
I believe I’m going to start with some dose of carboplatin + diclofenac + chloroquine + DCA + Metformin + Keto + Artemisinin and some natural supplements. Possibly a PPI on some schedule so as to not interfere with carbo.
probably its already taken by you but i read that resveratrol is making cells more sensitive to cis -, and carboplatin, just like DCA by the way.
Re ketogenic: I try to do this too. While i dont really miss pasta, bread etc. i do miss beverages… I saw spirits do not contain any CH at all- do you think its ok to drink spirits while on keto? the info online is not really straight on this…
As far as I can see, spirits don’t have any carbs or sugars. So in terms of Keto, they should be okay.
However, I don’t know how “okay” they are for cancer patients. I believe that alcohol can contribute to systemic inflammation. It also does have an impact on hormones.
I’m unsure about alcohol. I personally decided to quit drinking when I was diagnosed so I don’t think I’m too much help in this department.
It was a good decision, its indeed inflammative, but i meant in small amounts only, IT would be bad to come out of ketosis because of one single beer or two. Thanks for your answer, i agree with u.
i meant shots not beer:)
If you like and miss it so much, I think is pity not to have it from time to time a bit. In the end we have to also live today while fighting for tomorrow. But this is just the way I think and it may not resonate with all.
hi Meech ,
you have cancer starting from the liver, right?
did you try japanese chlorella as a supplement? below is an animal study for liver cancer, but i heard that some japanese oncologists (maybe Dr Hada can jump in here) recommend Chlorella to cancer patiens.
damages the DNA too
It actually presumably started in the kidney, although it’s poorly differentiated so that’s likely an educated guess in terms of the origin. I’ll look into this substance anyway though, thanks!
With great hope i write to you here that maybe this will help your mother just as it did for my mother.
Coffee enemas will help a great deal with pain and bowel movements i am surre.
I fail to see any significant downside to the enema procedure or effects.
Let me just say that enemas have saved my mother’s life in the past and i am sure of it.
I was but a kid and used to check if my mother was still breathing at night, in basic terms her boddy was very very toxic.
Once she started the enemas and a vegan diet she came back to a normal life within a week.
Thank you very much for your message.You always want to help people.
Sorry for writing DCA standalone.I mean DCA without chemo.
We used metformin,2DG,curcumin with DCA.
But CA125 is rising day by day.I hope the cause of the rise is coming from the
proteins released from dying cells.But very litlle chance.
Ah man, sorry to hear. I wish I knew what drove resistance to these compounds.
Although her CA 125 is climbing(doubled in 10 days after we switched to 600mgx2) ,
The other blood counts shows no progress.(My opinion)
I am searching and searching but couldnt find the answer.
Dou you have any experience about LDH and DCA?
May be there is stg going positive.
Unfortunately I don’t know too much about LDH. I know mine has been all over the place at random times. My highest value was just after TACE.
We got the blood tests.
Unfortunately ca125 rised to 54.
sorry to hear that ergin
when you will start chemo ? it will do the job especially with other treatments
4 to 6 weeks is good , chemo will do the job until they arrive
why do you think gas is from ascites ? there is a lot of things can cause the same
Thank you very much for your message.
We are going to dr tomorrow.He asked for a gene sequencing.
I send her blood to 3 different labs.CA125 is 85 in other 3.(NOT 54)
So from 2 months we were wrong about the ca125levels.
BUT i looked her past LDH levels and found that it was always higher than 200.Now 100.
DCA ,metformin and 2dg is working i think,.Her inorganic phosphor is high also more than 5.
I am thinking of necrosis but why CA125 is still rising?
I think it is just time to fight with chemo with this low LDH.
My mother’s CA 19.9 on our first test was 17.2, CEA levels did rise from 28.05 to 43.05 but the LDH levels stayed the same 148
These tests were made at a 20 day interval.
I am also wondering if this could point to necrosis.
Bes of Luck!
I forgot to say that CA 19-9 raised from 17.2 to 18.2
Hi Alex ,my phone charge is nearly finished.
I am 500 km far from home.Your words affected me too much.We have to talk more about your mom.
Dont do our falts.
When you take chemo 1 time,everthing about immunoteraphy changes.
Genes are changing.
You can try lots of things because she didnt take chemo.
I have a friend who never took chemo.
You should try immunoteraphy.
If you wish send a clear mail to Daniel,
He will open a new post for you.
It helps you too much.
And what i understand in 2 months in here is:dont write too much words in 1 message like this message?,people cant read everything.
When i write too long ,i understand nobody reads.
Especially nobody is reading the links that we send.Because they are too long.
First link and a small conclusion to attract peoples attention.
Keep with us
My dear ergin, i look forward to talking to you more, when you have some time.
Thank you so much for your reply here.
My best wishes go with you and everyone else reading.
Good luck in your adventure with all this, we all need it.
Hi Alex did you try artemisinin?
There is a village around here,a man cured some people with it,a legend.But on news i saw 2 years ago.Although he didnt sell it,they put him in jail just like the man with nerium oleander.
It is very important to know which gene changed some doctors says?May be you can repair or go over that treatment.
Hi Ergin, in jail for selling Artemisinin???
I am not sure he was selling.The history his like this:
He founds artemisinin on a mountain for spring only.
He boils it ,there is a video on internet.
As i know he gave it freely.
But at the end due to forum,police take him.
As my friend who passed away(nerium oleander doing at home)police took him for 1 day tell him to stop giving it to people.
Dear ergin, we tried the plant tea and plant capsules, for a couple of weeks.
Because i saw no positive change in my mothers state, only bad. We stopped that and we started aspirin+cbd oil. That worked great for a while, at least in my mothers mood, she had very little pain.
Maybe Artemisinin would work in some combination or higher dose, IV…. i don’t know.
I am wondering what you wanted to say when you said “don’t do our falts”.
Imunotherapy is extremely expensive, i am doing my best to try and help my mother with what i can aford.
My financial situation is very dramatic, i could make loans if something would prove to be very good for mom’s situation.
Thanks to Daniel i will soon be able to try some of the things talked about here. (i wouldn’t know where to stop staying Thank You for that and much more).
I am looking for your experience with them, so that maybe i won’t make the same mistakes.
My suggestions are coffee for blood flow, local hot water/towel, so that medicine can travel there.
Maybe Daniel will correct me on this, but my mother was experiencing pain reduction in the shower or when doing coffee enemas.
Take care, Good Luck!!!
I dont want to mix peoples minds but my thoughts about chemo is very bad.As i said before once you take it,everthing changes on cells.It kills some cancer cells but also developes cancer stem cells.Multi drug Resistant cells. It is there,you can use it later.First try different things.This is what i wanted to say.
She took oleander with chemo.First perfect worked,than no fever occured,because high dose chemo killed immunity.
Than i met Daniel….And our life changed.I understand the importance of METABOLIC TREATMENT.
I always add 1 drug to protocol,if it works alone or not.That was a very big mistake.Than i understand imp. of combination.Synergism.
1 drug works %20,the other %20,when combined:%80 for example.(Ofcourse it does mean that add all drugs.)
ALA+HCA is a good combination,you can search it.When i gave ALA to her,very bad stomach upset occured although she use omeprazole.So we go on DCA+HCA.
Then i add citric acid and you see the results.
Why dont you begin with citric acid ?
You have to use lansoprazole, my thoughts it is must in all cancer treatments.
I can send you some of the drugs if you wish like below.
Citric acid+lanzoprazole+ALA+metformin+MG(it come today)+beta glucan+melatonin.I take the others very hard from our customs like DCA+HCA.
If Daniel give my mail to you,i ll send all of them to you except DCA+HCA.
It’s very very late here for me but i wanted to say a few things before and then i will come back to this and continue.
I have a theory based on 4+ months of reading about this problem.
A tumour is made up of similar but slightly different cells, some die with a treatment, the others do not. and markers go down a little.
Please look here https://youtu.be/lpytoIxRu0o It’s a computer simulation of a tumour.
My theory is that some parts of the tumour will die with a treatment, others will not and would require other treatment. Or else they grow and markers come back up, same treatment would not help because it’s a different tumour, like a virus (treatment) that does not affect everyone in a city.
Something for Multi Drug Resistant cells https://www.youtube.com/watch?v=ED7yax2ee4c
I tried it with my mother and to be honest i don’t know if it worked or not, markers almost doubled in 20 days but LDH is fixed 148.
Getting Paw Paw capsules from the uk by amazon.com would probably take 2 weeks.
Meanwhile however you may be able to find the more accesible Graviola in your area.
Daniel or others may have better things to say about this.
Thank you for everything.
We will talk more soon,
Take care of yourself, so you can help your mother.
Please never feel bad when i asked for helping.The aim and the name is foundation as you see.
If i need help,i will ask for friends here.For example i need thalidomide:).If someone can send,i would very happy.
Never forget Alex,we are more than friends here.We are sharing pain and happiness.We are looking for new treatments and if Daniel finds a new treatment,we are happy alltogether:)
Donating foundation is better i think.Or waiting for what Daniel says.
I know for a fact (scientific evidence as Alberto would say) that the tumor/cancer genome undergoes a Darwinian-type evolution over time. I.e. there are mutations all the time and there is a selection process going on with the fittest to survive. Depending on what the tumor faces (what treatments and other microenvironments it comes across) it will mutate accordingly. As chemo is a very strong signal for the tumor to die, whatever survives will be all the more strong. Do you remember the Nietzsche saying “whatever doesn’t kill you, will make you stronger”? Well, it could not be more true for the tumors.
I wish you and your mom the best. I just read on another blog that people were treating their cancers (original one was prostate cancer with bone metastasis) successfully with molasses+sodium bicarbonate.
Thank you. Just for clarity, in order to help you, I did used donations I received from other kind visitors who donated to support the existence of this website. I decided to do that based on how much you are trying to help your dear mom and your difficult financial situation that makes it challenging accessing basic supplements.
I hope that will help and I would like to mirror your “Thank you!” towards those who kindly donated (they know who they are).
I have been following everybody’s posts with great interest. I do not have much to contribute yet. I have rare, aggressive ovarian cancer in advanced stage. I have last cycle of my frontline chemo to finish. I take metformin 500 mg daily. During my 5th cycle I added horse chestnut to potentiate chemo but it did not help and my CA 125 is plateauing.
I was talking about Salinomycin with Daniel but decided against it for right now.
I understand that DCA is a good option if you have tumors light up on a PET scan. My last PET scan after 3 cycles of chemo was negative. Does anybody have any opinion if DCA is still worth a try at this time to potentiate chemo or I should wait until I have active tumors for sure?
My comments are:
1. I hope you read this post on increasing chemo effectiveness https://www.cancertreatmentsresearch.com/?p=970
2. If tumors are not visible on PET but you know they are there, targeting mitochondria is a good idea. Here is a older Nature Review on that http://www.nature.com/nrd/journal/v9/n6/full/nrd3137.html Good and accessibel drugs and supplements targeting mitochondria are for example: Metformin, Doxycicline, Meclizine https://www.cancertreatmentsresearch.com/?p=667. Besides glycolisis, 3BP is also targeting mitochondria. Salinomycin too. If cancer cells are relying mostly on mitochondria, the mevalonate pathway may be upregulated as well in which case bisphosphonates such as Zometa may show anti cancer effects https://www.cancertreatmentsresearch.com/?p=1972 Indeed mevalonate pathway upregulation seems to be characteristic to advanced ovarian cancers https://www.ncbi.nlm.nih.gov/pubmed/27329838 and as a result Statins can also have anti cancer effects in this case. We should not use both Statins and Bisphosponates but make a choice between the two, since Statins will stop the action of Bisphosponates.
I hope this helps and may also be relevant for Ergin.
Thank you very much for searching and the links.
There are some clinicals trials on statin and have different results.Most of the secientists are agree with intraperitoneal infusion of drugs for peritoneal cancer.(IP)
Iv or oral drug does not give benefit on overall survival..Periton is a very different organ.Tumors may find different ways for feeding on periton.From periton fluid maybe.
For example targeting VEGF by anti-antiogenic strategy dont do anything to the tumors on periton in mouse models.But shrinks the other tumors on abdomen.
May be our solution is IP.Do you have any idea about IP?
Tumors will be directly incontact with the drugs.And there are lots of tumors on my mothers periton but as far as i know they are not more than 1cm.I have found an article,they use both tinzaparin and citric acid(IP) for peritoneal dialysis.But not for cancer.I am not sure about the dosage,is it enough for cancer treatment?The article is in my computer,i am abroad and send the link here next week.
Again Thanks Daniel
Indeed, peritoneal tumors are difficult to reach via oral or IV route. One way I know may be effective is practiced by dr. Thaller in Germany who may be able to deliver viruses via IP route: http://www.praxis-thaller.de/krebstherapie_englisch.html I know someone who had positive results using such treatments. Another option may be relevant is installing an IP port a catch and administrating therapies via that http://www.bardaccess.com/products/ports/peritoneal
Thank you very much Daniel for helping.
Thank you for everything you have done and do. I have read your answer to Tanya. I have a similar situatiion with my husband. Colon cancer, no tumora seen on PET, but cancer îs stil there. It was seen lymph nodes near lungs.What approch do you see, the best? Targeting mithocondrya ? What else?
You are very welcome and thank you for the kind words. The question is what is the origin of no visibility on PET. It could be that the there are tumors so small that are below the resolution limit of PET and sill functioning mainly based on glucose. Or it can be due to the fact that are not absorbing glucose, in which case targeting mitochondria would be a logical approach. Other than that, I would also focus on reducing the chance for metastasis using at least Cimetidine and possibly the others mentioned here https://www.cancertreatmentsresearch.com/?page_id=72 Anti inflammatory elements will also help, including high dose Omega 3 https://www.cancertreatmentsresearch.com/?p=1443. HCA may also help https://www.cancertreatmentsresearch.com/?p=956 This is what I can think of base on the info you provided above.
I hope this helps.
Thank you very much, Daniel.
The tumora source was colon which , you are right, probably it’s now very small. We started Budwig few days ago, Aspirin 100 mg îs taken, I’m thinking to add Cimetidine, as you said. Let’ s see , I hopa îs working. He’s taken also high doses of Vit C , at distance from Omega 3 ( flax Seeds oil and fish oil) and Budwig. What do you think about that?
Sounds good to me. I would replace the high dose VitC (if that is oral) with high dose Curcumin. I would also consider adding Mebendazole that should be specifically relevant for colon and colorectal cancers (but also other cancers) and easy to access. Here are a few more elements relevant https://www.cancertreatmentsresearch.com/?p=137
When tumors are small the immune systems has a good chance to work. So you may also want to consider immune activating elements such as Coriolus. Off course, all this depends on the (tumor and treatment) history, status and your treatment plans, since there are so many things you can do. If you like we can shortly discuss on Skype now or at the end of next week. If you are available now, just send me your Skype ID on the e-mail and I will contact you.
All the best,
Hi Daniel! I’m from Mexico, and we’re dealing with a case similar to Adinas. My husband was diagnosed with stage IV stomach cancer on September 2016 (liver and retroperintoneal lymph nodes mets), treated with epirrubicin, oxaliplatin, 5FU, keytruda, IV vit C, IV ALA, escozul, PSK, Celebrex, verapamil(only on chemo days), LDN, vitamin D, vitamin E, esomeprazole, melatonin, garcinia, aloe vera, B complex, wobenzym, diet. The oncologist told us he reached a pathologic complete response (clear PET scans, no malignant cells in gastric biopsies, clear laparoscopy and no malignant cells in peritoneal wash). From his oncologist treatment, he will continue with xeloda for three months and keytruda two years. From our alternative approach we would like to add something to target stem cells (we have already started helixor for immunity). And he is finishing helycobacter pylori treatment (amoxicilin and clarytromicin). I would love to hear your suggestions!!!
Thank you so much for this website!
Metformin against stem cells:
Salinomycin against stem cells:
Statins have also been proposed to attack cancer stem cells but I’m not sure if they’re proven to.
Thank you so much Meech! I have been researching a little and couldn’t find salinomycin in Mexico, do you know of any world wide provider in IV form?
Unfortunately I do not know a provider, as I have never used it. Sorry!
But I think Daniel and maybe other patients would have an answer for you. Hopefully they chime in here.
Thank you Meech! Hopefully someone knows!
Thank you for your questions and great to hear about the complete response, Jimena. It is good to see you used effectively a very heavy combo of chemo, immuno therapy and complementary. Did you do this at a specific clinic in Mexico? Btw, I would appreciate if you can tell us a little more about the clinics in Mexico (good or bad) in case you have relevant info. That may help others reading this website.
On the line of what Meech already mentioned, what I would do next to what is already planned, is to specifically focus on:
– killing cancer stem cells if they are still present (use several times SalinomycinIV, Metformin, Honokiol, continue enzymes)
– reduce chance of adhesion (use Cimetidine, Modified Citrus Pectin, possibly Honokiol)
– reduce chance of growth (I would add other anti inflammatory supplements/drugs such as Omega 3 next to Celebrex)
– add immune stimulating elements (next to the above I would add Coriolus, and probiotics immediately after finishing the antibiotics – one of the best probiotic is home made fermented cabbage juice). I understand Helixor you are using is mistletoe.
I underlined with bold the most important in my view. There are many things that can be done against CSC but this should be already good.
Note: Cimetidine may increase plasma level of some drugs including some chemos, so you need to check the interaction.
I will respond to your e-mail asap.
Thank you so much for your fast response Daniel! It was a heavy chemo but besides the awful nausea and the zombie feeling, his labs were perfect during the treatment (liver enzymes were elevated at baseline and reduced to normal levels after two months). His tumor was PDL1 negative, but after discussion with his oncologist about the heterogeneity of its expression in gastric cancer, he agreed to try it (thankfully the insurance cover for it). I’m a doctor so I administer all the other treatments at home, so we are not familiar about the alternativ clinics in Mexico at all, I do know they are almost all of them concentrated in Tijuana (near the border with the US), another one in Cancun and an other in Puerto Vallarta. CHIPSA uses Gerson along with IV vitamin C and coleys toxin. I personally believe that three week therapies are far below the required time, but I also don’t know what they do after the patient leaves the clinic.
Helixor is subcutaneous mistletoe, is the brand used in the clinical trial at Johns Hopkins, basically that’s the reason we chose that one.
Do you know of a reliable site to buy IV salinomycin that send worldwide?
I have been tempted for several months to add cimetidine to the protocol, but it’s kind os scary since we’re using so much things at once…
I haven’t heard of honokiol before, do you have more information of dose, brand, etc?
Thank you so much again! And also for helping us with the pheochromocytoma case!!!
Tank you for your response. Nice to hear that you are a doctor and can perform most of the treatments at home. Regarding the access to Salinomycin, there are two major options:
1. You arrange with a doctor that is already doing that – in your case Jason Williams may be a good option since I know he was using Salinomycin and was performing treatments in Mexico City. It should be very close to you. Here are more details on him https://www.cancertreatmentsresearch.com/clinics/
2. The other route is to do it yourself, but then you need to find a source where you can order. People across the word are ordering from western chemical suppliers such as those mentioned here https://www.cancertreatmentsresearch.com/salinomycin/ and are mixing it themselves. So far, it has been used in a few places across the world on compassionate basis as it is not yet an approved drug for human use, but with very good results.
If needed, I can explain by e-mail how we used Sal.
Here I wrote a little about the dose of Honokiol I would use https://www.cancertreatmentsresearch.com/cancer-treatments/
I totally agree: a few to several weeks of treatments offered by most of the clinics to advanced cancer patients are representing in most cases a too short time frame to expect much.
Hi Jimena, I hope your husband is doing well! I’m from Mexico too, I don’t know if you’d still see this but I wanted to ask if I could contact you? I’ve been trying to find a doctor who could help me mix and administer Salinomycin. If I can manage to get it first. So I just wanted to ask if you did use Salinomycin in the end, or if you know about any doctor here who would be open to use treatments like this. Thank you.
(And I saw there’s actually one of those clinics in Tijuana that administers Salinomycin, it’s called Immunity Therapy Center. I was going to ask them what’s their source for it, but then I saw that it seems to be a scam. Some of its Google reviews say that they told patients they didn’t have cancer anymore when it had actually spread more. I don’t know, in general the Tijuana clinics seem very dubious to me, they all have similar reviews about scammy things.)
If you have a doctor that can help you with the IV, I will help you with sharing the formulation (I developed many years ago) and the administration protocol I am aware of. All coming with the disclaimer on this website and for free.
Okay, thanks a lot! I wanted to add 2-DG and Salinomycin to chemotherapy, but I haven’t been able to find a trustworthy doctor that wants to do it. If I get one I’ll tell you. Thank you.
Daniel, my comment was taken for spam. I hope you can resurrect it because it is gone now.
I checked both the “thresh” and “spam” in the comments field and cannot find any comment. I am very sorry and apologize for that … this happened earlier to a few other visitors and I really cannot control that. It comes with the filter from World Press and if I deactivate that I will receive daily many spams. It seems that too many links or special links in the comments can trigger such events taking some comments as spam. I will try again this week to find a solution to that. Thank you for your understanding.
As you know we tried DCA with collodial silver for 1 week and didnt get any positive result.
But that days i gave collodial silver(CS) to my friend who is a valuable bird collector.
He has a bird which was very ill.Some tumors on body,1 eye closed,no hair on head.
He has put some drops of CS in its drinking water.Sprayed on body and head.
After 1 month past he called me today that the bird is healed.Hairs begin to grow,no tumors visible.
Ofcourse we dont know it was cancer or not and it is not human,but isnt it highly interesting?
I keep wondering if DCA could be be enhanced with the Budwick diet in adition to the other things that are talked about in here.
The coffee enemas seem to be highly beneficial in my mother’s case, she instantly felt better.
I know the science behind budwick and the coffee enemas is lacking, i wish not to suggest but only to inquire and learn about your experience.
Adina may be on to something here, i’ve been thinking about it myself.
It may make huge sense to do coffee enemas in the case of colon cancer, no suggesting it, i’m saying that maybe there’s a link
I am looking forward for Adina to share more about her experience with Budwick and everything else she may be trying.
Best wishes and respect.
Thank for your comment. Here I had a post about the science related to Budwig diet https://www.cancertreatmentsresearch.com/?p=1443 and according to that it should work well with pro oxidant treatments such as chemo and that would include DCA as well.
In case you like to ask Adina something you should just write a reply to one of her messages as that is the way to make sure she will receive a notification in her e-mail.
So just to confirm, adding Artemisinin on top of that would also enhance DCA to some level?
Best wishes and respect.
Arte may not enhance DCA effectiveness but based on the mechanisms behind they should work in the same direction and not opposite. But there was also a report suggesting that the combination of the two lead to toxicity in a patient https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5053977/
Thank you so much for all the information, very very very valuable and helpful.
Maybe the combination of DCA and Arte may not be a good idea after all upon reading that article.
Hope you have a good day.
Very big day today!
Mark February 28th 2017 on your calendars!
Kite Pharmaceuticals reported very strong results for its Car T Cells in lymphoma.
Trial also underway in leukemia.
So much great news out there!
H. phylori vaccine was found safe in 2015.
(Up to 85% of stomach cancer found related to H. pylori)
Article recently published suggesting that prostate cancer might relate to female menopause
and consequently might be preventable with anti-bacterial treatment.
Very good news out there!
It is very clear that why collodial silver is highly
Cytotoxic to some cancer types.Because it kills all bacteria.But nanoscale.Not CS done at home.
I believe future treatments will all be on nano particles.100 ‘s times powerful than big particles now we use in all medicines.
If it is nano sized it enters easily to cells.
Dear J. You are a good researcher,when i read your messages,i look arround is there any camera or not arround me:)We exactly are reading same articles.
Let me tell my idea:
Magnetic nano particles loaded with medicine.
If the tumor is palpable it is very easy to target particles by a simple MAGNET by the help of blood circulation.
When chitosan coated,it travels easily.When citric acid coated it is stable,salinomycin coated ,curcumin coated …etc.
Options list is too long.
The most exciting thing is lipided chemo.You send them by iv. Targetting them with cd44 or others.
And then release medicine on tumors with only a small heat.Very low dose chemo.
We have to think and talk with you.
Ergin reported bad results with DCA, he mentioned he was also giving his mother Curcumin, i wonder if that’s ok since Quercetin is to be avoided.
What about Ginger?
Just to be sure, are we talking about plants or extracts?
Hi Daniel , Ergin
Hope you are both fine
today my father went to a clinic in Germany , I don’t know about the clinic but he went to a doctor specialized oncologist treating breast cancer patients , he suggested to pay them about 4500 euro for diagnostics ( like knowing about the gene expression and the details about the tumors type .. etc)
Then maybe he will use a therapy that will target multiple hormones (if the tumor is sensitive to hormonal therapy) and also may ues enzyme therapy to target the liver mets , he also may use IV curcumin , but he is not sure until he knows every thing about the tumor after he take biopsy
he suggested many alternatives , he didn’t like chemo
at the end , in your experience is it a big plus to know more about the tumor ? or its a waste of time and money ?
Emad i have good news for you.I found procaine here.They use it for lab ,the phamagist said.I will work on it.
And one more thing.I learn everything from Daniel,please ask technical questions to him:)
Thank you so much my brother Ergin , I will wait for my father’s answer , maybe he can find time to bring it from Germany
if he didn’t find it then I will try to find a way to get it with your help
I already asked Daniel and he is always helping me all the time , I hope you can give IVs to your mother at home , try to do it with safe treatments , once you succeed you will have the ability to access stronger treatments like 3-BP + Diflu + Sal and use them as IVs
it was impossible for me at the first time , then I learned gradually , and things become possible
best wishes to you and me and all other friends 🙂
Procaine is sold in Germany at any pharmacy without prescription https://www.medizinfuchs.de/preisvergleich/procain-roewo-2-maxi-injektionsflaschen-10×100-ml-pharmarissano-arzneimittel-gmbh-pzn-4494039.html
Print this out for your father and he can go to any pharmacy in Germany and order. The German pharmacy suppliers are very fast, so if you order in the morning and they do not have it in the pharmacy they will get it for you so that in the afternoon of the same day you can already pick that up.
100ml of 2% procaine , if I’m right , I need to only take 2ml from it each time I give DCA !
if I’m right , its very very cheap
thanks a lot , this will indeed help 🙂
I looked everywhere and i found NOVOCAINA – Procainum IV
I could help with it if this is the way you wish to proceed, it takes quite a while to get it to you, but if you can’t get it anywhere else faster, perhaps this will help in good time. http://www.farmacieonline.md/medicamente/novocain-darnita-5mg-ml-2-ml-n10.html-5mg-ml
What is Procaine for?
I am still looking forward to find out how things are going with your mother, what you tried and what is working if anything is, and i hope that something is.
Me and my mother look up to you, Daniel and Ergin for all that we do for our loved ones.
Sometimes when i read these conversations to her she starts crying due to the amaizing things we talk about and the emotional aspect of the situation.
Also about the genetic make-up of a tumour, i am nowhere near as experienced as i should be to offer advice, but….
if you have a look at this video https://youtu.be/lpytoIxRu0o you kida realize genetic checking is very expensive and maybe not worth it. Personal opinion based on all the things i constantly see and hear, including that video.
Qualified or more experienced people may have something better to say.
I put a comment, is it still there as a spam ?
Not anymore, its published 🙂
Than you so much Daniel
I’m focusing now on DCA , I will support it with metformin and high dose lansoprazole , unfortunately we don’t found anything about Procaine here in my poor country , all they know is procaine penicillin , some pharmacies have procaine but spray not injection , I’m not sure if it can work as IV
i will see my father if he can bring some from Germany , also i will combine Sal with chemo at the same time and see
like always , i will continue to share everything in time 🙂
I wonder how you manage those lots of questions?
Can uou really find time?
I am doing my best Ergin but that means I have no time to write new posts on the website …
Daniel when I am thinking about you , I’m getting another question to you after all these
as a visitor and reader of your website , is there anyway for us to help you ? I mean , we need to also be helpful
I don’t like the fact that we are only asking and not giving any such help to you
sometimes my mind is telling me : hey Emad you can help Daniel by just stop asking him anymore questions 😀
my mind is funny huh 😀
sorry for going off topic
you are the MAN in this earth
Emad you are really a MAN,
You understand the situation of which Daniel is inside.
It is really hard for him to manage.
If i were him,i really forgive about cancer for some time.
He did everything for us,but we dont read what he wrote,we ask everytime same questions!!!
It is not humanity.
Thank you so much guys but the reality is that we are all special. Those commenting and those reading. Just because we are doing our best to inform each other. When I started my studies, my (former) thesis supervisor told me: “Communication is more important then the Physics that you know”. I did not understood at that moment and found that strange. But in the mean time I realized that only communicating and collaborating we can learn a lot and fast. No one knows everything. Each of us adds a bit of value, and with that together we can create value that goes beyond normal. We have many valuable people contributing here (including patients, caregivers, medical doctors and scientists), so lets not forget to give credits to them. This is why each of us is the MAN or WOMEN and hopefully with what we learn we can take better decisions. So thank you all for helping each other to advance our common knowledge. Questions are always good. Lets keep addressing questions and we will answer as we can!
My words are not for you.You are the one that first attracted me to be a member of this page.
You are totaly different.Your aim is exactly to help your mom and the others,this is very clear.And you are very clever.
My words is for the ones who only asks and never mind to help others.And they communicate with me by mail.
It is time to talk in other treatments.We have lots of roads to run.Our questions and aims are gone when same questions come into life.Daniel tried for lots of months to write,and they smell full of knowledge.
Daniel dont angry with me,that is my idea.I want to see new links new ideas.You already done lots of works.
Thank you so much for you kind words Ergin
also I hope my questions here in this blog are somehow valuable 🙂
best wishes to you all my friends
Hello, I’m new here
I am in Australia and unfortunately shipping of DCA takes many weeks coming from standard international suppliers. I found a source in Australia
Has anyone used these guys before? I’d love to have a product review.
Thanks for your msg. The website looks a bit strange to me. If you like, I will connect you via e-mail with some cancer patients or family of patients from Australia. Maybe they have an idea where to get it in Australia.
Besides that, would be great if you could contribute to our discussions here when possible, given your impressive background in science.
Thanks for your reply and invitation to participate. I look forward to learning more and joining discussions. I really like the site and think the community here is ahead of its time.
As for DCA, I ended up ordering from puredca.com for now.
Yes, please do connect me people you know from the cancer-fighting community in Australia. I am representing my brother (32 yo) who has metastatic osteosarcoma in the lungs.
I sent to you the address of a pharmacy in Australia that can help you with DCA. They should also be the best to connect you with people in Australia fighting cancer as they are very well connected with them.
Here is an Australian friend fighting cancer for very long time: http://petertrayhurn.blogspot.nl/
We are also looking forward to see you posting and growing our knowledge together.
Dear friends, Daniel.
Would there be anything of value in this video for us? https://www.youtube.com/watch?v=8uY3bfU3vG4
It’s about DCA and you may or may not be familiar with it already.
Thank you very much.
I was just reading this article. I know it’s Mercola, but it features some impressive thoughts about what Turkish doctors are doing with metabolic therapy as an adjunct to lower dose cytotoxic drugs.
I think it’s a quality read (it’s a little long).
Thank you Meech
I wonder if metformin removes the need for the ketogenic diet or not.
Metformin lowers blood glucose levels in part by inhibiting the Cori Cycle in the liver. This cycle converts excess lactic acid back into glucose. I personally think Keto and Metformin are good adjunctive therapies but Metformin wouldn’t cover the entire scope of lowering BG. Also, the benefit to Metformin does far exceed its ability to lower BG.
Secondarily, I don’t think a low blood glucose necessarily results from a Keto diet. I’ve been on the diet for about a year now, pretty strictly, and my BG remains within normal parameters. Even while fasted. I can’t remember why exactly but I remember reading an explanation. Maybe Daniel would know.
Nice Meech. Thank you for the very useful link. I also like the most the metabolic treatments, as they are the most controllable and effective when used wise. I nearly 100% sure, the Turkish clinics are currently implementing 3 BP as well.
That clinic belongs to 2 doctors and Dr. Abdul Kadir Slocum(right on photo)is their student there.
He will be good doctor.He is American origin.
Prof Bulent Berkarda(first oncologist in Turkey)and Dr Salih Kesici are 2 doctors in the same clinic.
They said they have a record on survival of pancreas ca.
They use iv mannose,iv sulphur,iv iron,iv vitc+HBOT+hyperthermia+2DG+quercetin+artemisinin+beta glucan+curcumin injections+melatonin+metformin+DCA.They have salinomycin but didnt try yet.
They always said please force your mother to enter HBOT.And they show me very good pet results only with HBOT.
I will go near them this week,because i want to talk about phlorizin if they can use it or not.
And some of the iv ‘s are their secret as he said.
I am very sure when they learn phlorizin,they will use.
Any question?I can ask them.
Thank you for the information; their progress is something I’ll definitely keep an eye on as I firmly do believe that there is a place for chemotherapy.
Absolutely, if you could please ask them:
– the schedule when administering anti-glycolytics (does it matter if DCA, etc. Is given concurrently on the same day as therapy and beyond or if there are days to withhold it.)
– what form of ketogenic diet they’re implementing. How many grams of protein per kg. Thoughts on consumption of meat products.
– dosages of the glycolytic inhibitors if possible.
Thank you very much ergin.
Does anybody have any experience with higher doses of DCA? I’m talking 35mg/kg and up. I have progression with about a year of 25mg/kg, along with other therapies (albeit growing much, much slower than you would anticipate for an 80% Ki67% cancer), and was thinking of taking it up a notch experimentally.
We used 55 to 65mg / kg IV for some weeks without specific side effects, but as you know the side effects can be more or less from person to person.
Thank you, Daniel. Any anecdotal stories of response/non-response at those doses?
Nothing specific that comes to my mind … there may have been some temp responses, but what I do know are the serious responses at the normal dose as mentioned in the post above. Besides the dose, I would also focus on the approaches to try increase the effectiveness of DCA as also discussed in the post above.
Hi Meech, i presume you aren’t using chemo.
Anything else you use besides ketogenic diet and DCA?
I have not been on chemo since June of 2015. I received 8 TACE sessions and 2 sessions of microwave ablation from Dr. Vogl for liver mets, which was highly successful.
Apart from the DCA and Keto, I take Metformin; Melatonin; took 2DG while undergoing TACE but constant use proved expensive so I have not been on it in some time; EGCG; Graviola, Propolis; Ashwagandha, Astragalus; Milk Thistle. I was previously taking Artemisinin but stopped for a while because the amount of liquid was somewhat too much. I have restarted again at 3 cups of cold-steeped artemisinin tea daily about three days ago.
I firmly believe that adding a cytotoxic would be beneficial in my case and many others.
Thank you meech,
i am curious what graviola are you taking? And how much of it? I noticed mother feeling better with it, so i ended up spending a lot of money on graviola tea powder and paw paw capsules. 1kg of such tea powder.
Sadly her feeling better seems to only have been a strange ilusion of sorts. CEA level raised from 28,05 to 46,05 in 20 days of using it at 50g of graviola leaf powder tea+6 capsules of paw paw each day. This was a standalone treatment.
Congrats on your achievement with the ketogenic diet. Keeping the regimen for so long is an achievement in my opinion.
Maybe use some more of that microwave ablation thing again? i wish i had access to something like that for my mother.
How about diclofenac, aspirin or citric acid?
Cytotoxic i feel should be selective
I’m glad you’re with us to share your experience.
So it is my understanding you take DCA+Artemisini correct?
Please check my other reply here.
Thank you very much,
Yes, I’ve re-started artemisinin a few weeks ago, and I do take it with DCA. I know somebody said there might be a risky interaction there but I haven’t seen any issues thus far, with a high dose of DCA.
I steep the full plant/dried leaves in cold water overnight and drink it three times per day. I drink it five days per week.
So…. should curcumin, ginger, resveratrol be removed from the protocol when using DCA? Just to be sure asking.
Should i get procaine?
Would Paw Paw be relevant still?
Thank you very much.
Ok friends, remember 2weeks on, 1 week off.
A bit stunned here…..
In this article https://www.ncbi.nlm.nih.gov/pubmed/27356574/ “Maximal effect, an increase of LS by 34.5% (p < 0.05) was detected at a dose of 1.5 g/kg."
Can that be real or a typo?
I hardly believe that for a person that has 100kg for example that the daily dose should be 150g of DCA or more if that's just one of 3 doses. making it 450g of DCA daily.
Thank you Daniel for your ongoing work and help.
Using it as a standalone therapy and with chemo or others are very different.
I began DCA because Emad examined DCA helps chemo.It is exact.
And our DR said very very good responce with brain ca.And not 150 gr:)
In medicorcancer trials:They use DCA with thalidomide and only after 2 weeks later they see a responce or not.Because you have to wait for thalidomide to work(copper chelation).And there are not too many reports on that.Angiogenesis inhibitor is a must in any treatment.
When i used it as a standalone therapy,i did not see any responce,opposite CA125 doubled.
They also wrote there,wait for some time on DCA.If it doesnt work,leave it.
Daniel has some suggestions on how to make DCA helpful.
Sorry not thalidomide in medicor trials,it was Tetrathiomolybdate (TM).
I understand ergin, but the article linked by daniel is saying that the best dose is 1.5g/kg
Cancer compass is vetting my posts, so I thought I would resubmit here. Anyone have any ideas what the German investigators and or police are up to?
“im Sande zu verlaufen” hmm..
Auf Englisch bitte!
“Derweil eskaliert ein Streit um die Ermittlungen: Polizei und Staatsanwaltschaft erstatten Anzeige gegeneinander und sind sich über die Tatvorwürfe uneins.”
Unklar ist jedoch, ob aufgrund der instabilen Natur des nicht zugelassenen und umstrittenen Präparats 3-Bromopyruvat , das der Alternativmediziner verabreichte, ein Zusammenhang der Behandlung mit den Todesfällen überhaupt nachweisbar ist.
However, the unstable nature of the unauthorized and controversial preparation 3-bromopyruvate administered by the alternative medician is unclear as to whether a connection with the deaths is demonstrable at all.
As the Krefeld Public Prosecutor stated against DAZ.online, a special investigation procedure is being developed for the investigations to alleviate or eliminate the suspicion of three cases of negligent killing and two cases of negligent bodily harm. The scientific evaluations of the appointed expert would still have to determine the extent to which the curative practitioner caused the deaths .
Wie die Staatsanwaltschaft Krefeld gegenüber DAZ.online erklärte, wird für die Ermittlungen ein spezielles Untersuchungsverfahren entwickelt, das den Verdacht auf drei Fälle mit fahrlässiger Tötung sowie zwei Fällen mit fahrlässiger Körperverletzung erhärten oder ausräumen soll.”
What are they saying? I want a good translation before I comment on this. Anyone help out?
I reformulated a bit my earlier response:
I think this is an attractive subject to discuss. Half an year ago I initially wanted to write a post on it.
However, after careful considerations I decided not to start discussing this subject, on this website. The reason for that is:
I like to focus on building and not destroying. I think the subject you are referring to is an example of a value-destructive news, reflecting a mistake or unlucky coincidence that is typical in this world, and typical in the medical world in both hospitals and private clinics. My wife and I are perfect examples of that: a few weeks after my wife was treated in a conventional hospital with “water” for constipation (high dose saline 24h/day/3days in a row induced edema and washed out all the minerals) I lost her.
In addition, it becomes clear that if there would be evidence that 3BP was the reason for what happened, that would be clear immediately and the man would be already accused for that. But so far he can only be accused of medical negligence. That is enough for me to understand it was not 3BP. And knowing that 3BP was very safe and helpful for us while using it for long time is also enough for me.
3BP is value to humanity. Mixing that with potential misuse of that value is something we should avoid.
With the above in mind, to me, what happened at that clinic is an outlier and it should be treated at such. Therefore, starting a discussion here on this subject takes us on the wrong path. It will become a long discussion that will misuse our time and energy. I think we better focus that on growing out knowledge instead.
I very much hope you resonate with my arguments above, as I very much value your contribution.
Sorry for adding negative energy, D.
I suspected that you wanted to move beyond 3-BP, as your 3-BP has been silent since last August.
Even still I wanted to post this because it appears that the story is now rapidly being reinterpreted.
We should know the details by the end of this month.
Probably best not to comment until then.
No problem J. Thank you for understanding.
I actually would like to further discuss 3BP, as I think is one of the best anticancer elements we have.
But would prefer to discuss the science and its application, as I already spent too much of my time around the problems they encountered at Bracht.
I only have one note on the subject: you recently posted a link showing that 3BP is allowed in Germany if prescribed by a medical doctor. If the German investigation team would find 3BP as dangerous, I believe it would simply be out of that list already, which is not the case. So, according to that, most of the clinics in Germany can use 3BP and even formulate it themselves in the clinics, as long as the clinic is run by a medical doctor. As a result, all the signs point to the direction that 3BP was not actually the problem there.
If this is truly the new narrative, then there has been a substantial change. This has taken me quite by surprise. The reports suggest that the German investigators and police started squabbling last August. I really want to see a thorough and comprehensive report of this incident. I hope that they will recreate the preparation method used by the doctor and provide an estimate of the dosing level of 3-BP that was given to the patients involved in the incident and others treated at the clinic. Providing a clinical summary of all the other patients would also be invaluable information. With almost 100 patients this would be equivalent to a phase 2 trial
Even most in the 3-BP had conceded that 3-BP might have at some level been involved through a dosing error etc. . Interestingly I have noticed that the psiram site actually no longer has a 3-BP site. Does this mean that they no longer think it is quack medicine?
Gave mother the following this evening now.
Cabbage Brine – about 200ml
Alfa Lipoic Acid 600mg
30 min pause
Citric Acid 5g
We stopped the resveratrol tincture drops due to possible bad interaction between it and DCA as mentioned in this article.
Suggestions? Opinions? Please.
Thank you very much,
I was reading about DCA lately, and have made a few possible connections.
We have the 2 weeks on and 1 week off.
Then there are statements from the scientists in canada saying that DCA inhibts it’s own metabolism and that it takes about 2 months to reach peak values in the boddy, or something like that if i remember correctly.
There is also Emad saying he got better results with a specific brand.
Then there is Ergin saying he saw no benefit from using DCA for his mother.
What if all these are the effects of wrong dosage, and time not being given for DCA to work.
Also i would like to remind you that one of the articles linked by you says that for maximal effect DCA dosage should be 1.5g/kg, would most likely be a typo of sorts ?! https://www.ncbi.nlm.nih.gov/pubmed/27356574/
Re: dosage and scheduling.
I’ve been on 25mg/kg for about 12 months now without any time off. 7 days a week, continuously.
I am now attempting 31mg/kg (just over 2g daily) as of yesterday. If tolerated, I’ll move it up a bit again.
As for the dose cited in the article, rats are generally given a higher concentration of drugs IIRC due to metabolic differences.
I was wondering, how are your thyroid hormones. I was triggered by this article https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4808550/ while also looking at this one https://www.ncbi.nlm.nih.gov/pubmed/19846915 and having in mind this one https://www.ncbi.nlm.nih.gov/pubmed/25410096
I don’t believe I’ve ever had my thyroid hormones checked (unless certain tests indirectly have checked for those levels), I will definitely be reading your articles you posted, thank you! However, I don’t have renal cell carcinoma. I do have a primary kidney cancer, but one which has never been diagnosed in anybody except me, according to everything I have looked for on the web (Combined small and large cell neuroendocrine carcinoma of the kidney). The articles may still be relevant though, as maybe the originating point carries specific changes to the cancer.
There are 2 REAL cases about DCA.
I am the 3th real case you can only find on internet like these part by part.
Because i used it as a standalone therapy,without TM.
Another case ,she had hypothyrodism and pertioneal cancer just like my mother.
I didnt see any relieving of bowel obstruction but they saw.
As a result:my opinion,it is individual like other substances.
Thank you ergin, i hope to talk to you again on skype, and please consider enemas for your mother’s bowel issues.
in the second case you presented it says this:
“the cancer came under control with DCA+TM treatment. The CA-125 increased slightly at the start of treatment as expected because of the 4-8 weeks it takes to create maximum copper deficiency. The CA-125 fluctuated slightly, but remained in the range of 39-55 for the next 6 months”
I wonder, did your mother take DCA for 4-8 weeks?
At the specified dose: (23mg/kg/day) on cycle of 2 weeks on / 1 week off.
If so, i ask, any results?
I hope you have good news,
Please take care,
Yes.she took 12 weeks DCA.
5 days on,2 days off.
I was always thinking no responce,but we didnt know after stopping it,may be CA125 will be higher,who knows.
We are on chemo now with different combinations.So talking on probabilties from now on is nonsense unfortunately.
But still i feel that it was working with chemo in the beginnings.
Tomorrow i ll write on ovarian post.
Hi Ergin & Alex,
I posted about LDN in another thread. I hope you can take a look and maybe benefit from it? The article claims 60% of cancer patients can benefit from LDN.
This cancer….. it’s like the terminator, always coming back.
I keep thinking about how they killed it in the first movie, with pressure, and then i reminded myself about you and HBOT.
THen i started to think about the human endurance to high pressures. Any max values.
The more you read and think, the more you start to realize how random and lucky it must be to get back to normal health.
This thing had millions if not billions of years to evolve, getting it to die is highly unlikely sadly.
I’m happy to report that mother is feeling better and i hope it keeps up. Still i feel i should be vigilent and not too ignorant.
But yes… LOST and need a vacation on the beach.
i invite you all to the black sea this summer, we need to have a good time and get some good sea food down + sun exposure for optimum health at Techirghiol and Eforie
Also i am wondering about tetrathiomolybdate for copper depletion. Where to get that?
This question mean you didn’t read my post on TM 🙂
So much to read here, you can get lost…..still the information is distilled.
When you feel that, you need to zoom out – nice photo 🙂
Yes, i need a vacation on the beach……. omg………’
We all need it.
Techirghiol, + Eforie + Sea Food + Sun Exposure
SO much good stuff.
It’s an invitation.
My mother is experiencing accelerated hair loss, i wonder if any of you have been seeing this with DCA or other treatments.
It may also be the case where something else is wrong.
I would check basic hormonal status, including Cortisol and thyroid hormones T3 and T4. Lack of proteins in her diet can also be the origin. Anemia can also be the case. Vitamin B deficiency. All can be checked with blood tests.
Maybe others have more ideas?
Thank you very much for your input Daniel.
You always seem to nail things. So much to learn.
Will do our best to identify issues.
I hear about nagalase and CTC. Would you say they are something we should look for?
I wish to encourage you to make Testing section or article *we are all looking for the cures but not enough info on testing i fear*
There’s the must have, the useless and the pointless…. and who knows how many other categories. And i feel a discussion on testing would also have a major importance.
Nagalase, not really since all those active in GcMAF are being closed down and there will be no one producing GcMAF. But anyway it was expensive and usable only for early stage. CTC is too expensive, Alex. It was about 500 euro just checking CTCs. And you would need to do that every month.
Hey, at least talking about them is free right!? 🙂 LOL
Yet again we come to the requirement of a testing guide of sorts.
Pros, Cons and all that.
Please take care,
Would it be possible to increase protein intake without feeding the cancer? Vitamin B, Folate
Thank you very much
My mother didn’t experience something like that with high doses of DCA , also her hair is growing despite taking Carboplatin and Gemzar + DCA
she only lost her hair due to Taxotere
Thank you very much Emad
I hope you and your mother are doing better and that you have good news to share with us.
thank you Alex , I also wish the best for you 🙂 , we will see the results next week , and will share everything here like always
Emad, have you thought of adding low dose 5-aza? On the compass there has been some excitement raised by this treatment possibility. It appears that many cancers could benefit.
Best wishes, Jcancom
Could you please give us some hints about it.
On the compass thread we got started off with someone with testicular cancer. I read up on it and found PMID: 27936464 (click through it’s free!) . 5 nm? These demethylating agents look like they could be quite powerful especially in germ cell cancers.
Yet, it appears that a broad range of cancers could benefit from low dose demethylators.
The current generation drug 5-aza might not be a great test of the theory as it has a short half life.
Almost hard to imagine that these drugs have sat on the shelf for almost 50 years and were used at high doses which resulted in numerous fatalities in clinical trials that offered minimal benefits, while simply reducing the dose might help to unleash their potential. Other combos might further enhance effects.
The idea here is that demethylating cancer cells can reveal all sorts of genes that would work against cancer. Typically there has been a fair amount of skepticism about targeting a single mutation in cancer treatment as cancer will find a way around it. Yet, what is interesting with demethylation is that there is a truly enormous amount that occurs with these drugs. There are probably multiple anti-cancer genes that become reactivated.
However, it is still quite possible that resistance could still emerge through mutation in the DNMT1/3 genes.
At the same time, 5-aza has a short half life, so there has never been a good test of using it at low doses perhaps even a few times a day to try and create a good demethylation effect. This could be monitored during treatment.
I’d love to hear what D has to say!
Hi J , hope you are fine
I never heard about 5-aza , where can I find it ?
I’m focusing now on DCA + procaine + high dose lansoprazol + CA + HCA , I run out of Salinomycin but wondering if the effect of base version is the same as the salt version , even when they have the very same side effects
also will be very happy to add 5-aza to my attention 🙂
hope I can know my more about it
Emad, best wishes and congratulations on your sustained treatment success.
Sorry for being confusing.
This started for be by looking up PMID: 27936464.
There is now a fair amount of interest and clinical research with these demethylators.
It appears the demethylaiton effect could be broadly applicable to cancer (lung, breast …)
Guadecitabine is in phase 3s and might be a few years out for approval.
It seems that it could be an extremely powerful choice in refractory testicular cancer.
5-aza (5-aza deoxycytidine) has been used as a cancer medicine for decades at high doses and did not appear overly effective. However, the demethylators are now that to be effective when used in low doses.
bro, how is your protocol going? is it still the same as above?
How is your mom?
My mom is back on DCA, we got markers value increase with CA. 🙁 To be honest, not surprised but we gave it a shot.
Hi dear Alex
my mother feels better today , she had a hard time past week but now she feels better
I shared the results in details in my post , still using DCA + chemo , but I will stop DCA once I receive 3-BP and Sal , I will stop DCA because of neuropathy
I hope your mother is feeling fine , I saw your mother results
the markers are growing slowly , I believe its a good chance to do extensive search and bring up the best strategies
how about MG or thalidomide ?
also, I have an important question
does your mother have a medical port placed on her or not ? if not , is it possible to have it done ?
Thank you for your reply Emad,
i’m most delighted to hear she is feeling better and i hope it keeps on going towards the best.
Would you please point me to your results post?
Where did you order 3-bp from or Sal?
What was the dose used of DCA and the method used to adminster it? Also, how much would you say is the optimum dosage for DCA from dcalab
I will do my best to try to help my mother as much as i can.
About MC or Thalidomide, i have more reading to do….. 😐
no port installed, anything is possible for the right money and reasons.
Best of luck,
I ordered 3-BP and Sal from a western supplier , I am cautious to share the company name here , if you ask Ergin or Daniel or me in a private , they will mention it for you
the oral dose we were using by DCA is 20mg/kg , 2 weeks on , 1 week off , or you can do it 5 days on , 2 days off
for the IV , we were using 70mg/kg every third day (1 day on , 2 days off)
its not different from what is mentioned in this post
yes you should read more about Thalidomide and Methylglyoxal
regarding installing the port , I can’t say that its better to install one for your mother , this is your choice
but once you install it , giving IVs to her will be so much easy
installing it will require a minimal surgery , you should not use aspirin or any NSAIDs before it
if it sounds a hard thing to do , don’t try to do it now , but just give it enough time to think about it
I wish you the best Alex
also it makes sense to add the strongest natural demethylator : EGCG. works against ovarian and testicular cancer for sure.
I think it is available as IV in Germany.
This subject is new to me. I would need to first research the subject in order to have a helpful opinion. It will take a bit of time for me to come back with my thoughts on this subject as I will travel during the coming two weeks and will probably not find the time for researching new subjects. I will do my best, but if I forget to come back on this subject, please send me a reminder. In the mean time, if you can make it even more clear it will only help. Thank you.
So i am wondering if and when doing the 2 weeks on and 1 week off scheme, would it make sense to use resveratrol in that one week?
Alex, out of curiousity, how much dca is your mother taking? thanks.
500mg X3 / 75kg
I was wondering if 500X4 would be better…..
take care with DCA. i did not do a pause after two weeks and continued for another 2 days at 25mg even though i do know the recommendations. this was a mistake.
I was very ill for a few hours: very high blood pressure, freezing, nausea, all kinds of strong aches in all my limbs, i almost went to a doctor but a rest helped. by now im fine, but i am off for 7 days and reduce back to 20mg. i take b1.
this was a lot worse than any side effect on cisplatin, etoposide and bleomycine for 4 rounds.
Thanks a lot Wondering for reporting this event. This is a good example on why we need to be careful with everything we do. Fortunately, DCA side effects are reversible. But we need to learn from this. Personally, I would not push up the dose of DCA. Instead I would stay in a safe dose and look for ways to increase its chance for effectiveness via approaches such as discussed above.
and the scary thing was that it did not have any slight precedence in the days before, like with a “normal” chemo. just bamm…
update re my main symptoms after 16 days dca use:
– back pain the same.
– i have much less fasciculations, its not so hard to quantify it
what was the origin of the fasciculations that now are much less, Wondering?
doctors did not know as my spinal mri was clean and it usually occurs (if not benign) due to motor neuron diseases ( which i dont have) or cancer (which i have), especially leptomeningeal mets (which i fear i have, along with other symptoms like back pain). i had so many fasciculations a day that i stopped counting. now its only 2-3-4 per day and i feel better overall. It would be a strong case of placebo, its not pain which is highly subject to that.
it feels good to not have these! (appeared first in december and the frequency kept increasing).
its crazy. by now the constant back pain is a LOT milder too. it was around 6 strength (out of 10), now i would say 3. The back pain was there since september and it was slightly getting worse. one could argue that it might be a very strong and strange placebo (since other symptoms also improved that are less subjective) but before I also took lots of pain killers and supplements (not to mention chemoterapy) and nothing worked so far. now after 3 weeks of dca im better!
The interesting thing is that most improvements happened after my few hours illness (shivering, freezing, high heart pressure, seemingly wrong blood circulation and weakness) on friday which i thought was due to an dca overdose, i did not do a pause after 2 weeks.
autocorr:high blood pressure*
so happy for you that some of the treatments seem to be working for you. What you experienced is most certainly a Herxheimer reaction and it is a good thing. It shows your body/immune system reacts to probably the new medications/treatments you started to take.
thanks for the link, Helga, i was not aware of this (tumor lysis syndrome i knew of but it seems its a wider spectrum now based on the link). You might be right as I had all the symptoms the wiki is mentioning while the DCA overdose does not look like this in other reports, so i was kind of confused and even reported my sickness here (see above) . Also I had something similar after my first cisplatin chemo ( and not later) but then it was milder and shorter (then it was obvious that its chemo working).
was trying to find more info on herxheimer in cancer but it is not mentioned really- only in terms of tumor lysis syndrome. I certainly dont have huge tumors… but any other disease either. Interesting!
maybe this can help http://www.lemonandlyme.com/Articles/Expect/Herx.php
is not in cancer but it doesn’t matter since the mechanism is similar
Stopping DCA for a week now,
2 weeks since received and started,
3X500mg – nothing worth mentioning about side effects or observed benefits. – Tests needed.
Metformin “appears” to be VERY effective only when migranes exist.
Citric Acid “seems” to be *NULL* ineffective even at 15g/d – My mother is a champion, she can take that like a pro and not even blink.
500mg aspirin + 500mg Metformin + Diet = Strong results (so it seems).
50mg Diclofenac seems to help somewhat but only if aspirin is removed (side effect risk)
Quote marks used to specify that i have no data to support that.
I hope this works….
Omeprazol 20mg X3
Alfa Lipoic Acid 600mg X3
Metformin 500mg X3
Diclofenac 50mg X3
HCA 3 capsules – X3
Citric Acid 5g – 3
Mother’s weight ~75kg
Suggestions/opinions welcomed please.
Thank you very much,
How’s your mom feeling? Any changes from before she started with all of these medications?
we started around 6th of march,
DCA only for 2 weeks and stopped now as a brake,
She feels somewhat better…………………
The thing on her arm changes size and density from day to day….
I don’t know what to say sadly. Maybe it needs time or adjustments, or aditional elements to be added.
Shes been abusing bread, and didn’t feel good…. so my advice… stay away from it.
I wish this was a computer job, i’d fix her up in no time. Sadly… we are too complex and i have no previous experience.
Sometimes it’s tough to tell based on one tumour how the overall body is doing.
I’ve had palpable supraclavicular nodes since my diagnosis in 2014. Confirmed by CT scan as being outside the range of normal. They haven’t changed size at all apart from maybe 2mm or so in two years. However, other stuff has grown and shrunk in that time. I wouldn’t necessarily take the one module as an indictment of the bigger picture.
I’d give the “give up bread” advice to even those who aren’t fighting disease.
“Module” should be “nodule”.
Thank you very much Meech.
Good luck there.
Alex, do i remember well that that thing was not biopsized yet? if this is the case I highly doubt its cancer based on your description.
the original tumor was biopsied after surgery. there was no other medical intervention after.
thank you again for your reply
OK, so there is no evidence that thing on her hand is cancer. maybe anothr biopsy would help to make you less nervous.
Forgot to mention
Milk Thisle – Silimarin
hi Alex. your mom is taking lots of useful stuff.
I know its hard above a given age but maybe some sort of keto light diet could help your mom.. At least low carb. I know that russian cuisine is far from it (just like most in europe). maybe focusing more on your brilliant soups and less on bread would also help?
If she feels better on it after a while thats probably a good sign. also its quite anti inflammatory. It might be difficult I know, especially for an elder men / women.
Thank you very much Wondering, i will try to help her towards a low carb diet. Sounds like it may help her situation given the things observed,
Well i’m very interested in Ketogenic Restricted Diet but its hard to find any certain info on it, for beginers.
Any links suggested?
Romanian cuisine 🙂 https://www.youtube.com/watch?v=8NiRDn0ci-Y + Many others.
My mother is a champion, she will do whatever it takes diet wise and not just that. I am very proud of her.
Do take care,
Yep, sorry, in the meantime i realised you are my “eastern neighbour “:)we have some common foods.
http://www.ketogenic-diet-resource.com is a nice page. they dont deal with restricted version, but for this you can keep in mind following daily values :
” carbohydrates to 12 grams a day and protein is restricted to .8 to 1.2 grams (I use 1 gram) for every Kilogram of body weight. The rest is Fat”
quite difficult! i managed it for one month – gave up on it a bit and now i do fasting + low carb.
https://www.ruled.me/guide-keto-diet/ has some nice info too.
and all the studies use normal ketogenic diet..so restricted one must be even better for adjunct therapy.
I remember the point was to be restricted – otherwise could be worse than normal diet regarding the tumor growth …
Yes, this point was made by seyfried too but a ketogenic is very low on glucose and ch already, hence Anti inflammative. I doubt its worse than our normal diet but i agree, restriction is important.
If you check the ncbi study you see they had results with normal keto too…
Thank W. That is what I heard, but I will have to study the subject in details to understand and have own opinion on what makes sense.
I have a bad news today , actually bad for me and my poor mother
tumor marker ca 15-3 raised from 322 to 607 in 5 weeks
I am sorry to hear that Emad. But lets hope and expect that will go down again.
What were the treatment changes during this time? Any change in Chemo?Are u still using Salinomycin? Still using DCA? Others?
Also, please let us know if we can help you in anyway.
I sent an email to you dear Daniel
thanks a lot for your respond and care and help
Hi emad, truly sorry to hear that. Pardon me, what cancer does she have and What is she taking altogether?
DCA makes cancer cells to Cisplatin more sensitive;
anybody receiving cisplatin should consider to add dca in a safe dose before and during chemo in my opinion based on above.
– cisplatin is not just damaging dna, its destruction depends on functional mitochondria. (cancers with functional mitochondria are more sensitive to it). I assume functional mito does not mean it is used too instead of glycolysis
– DCA promotes mitochondrial oxidation — ) cisplatin can kill more effectively
no impact on normal cells.
Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis.
Thnaks for the reference. I included the ref here as it may a PKM2 inhibitor https://www.cancertreatmentsresearch.com/natural-killer-cells-fight-cancer-as-a-metabolic-disease/
Where can one purchase y-Tocorienol?
“Tocotrienols are compounds naturally occurring at higher levels in select vegetable oils, including palm oil, rice bran oil wheat germ, barley, saw palmetto, anatto, and certain other types of seeds, nuts, grains, and the oils derived from them.”
Specifically, I found that palm oil is high in y-tocotrienol.
I also added a source here https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/
“Life Extension, Gamma E Mixed Tocopherols, 60 Softgels” is “Gamma Tocopherol “, not “Tocotrienol”.
Swanson Ultra Double Strength Tocotrienols
Healthy Origins, Tocomin SupraBio, 50 mg, 150 Softgels
Swanson Ultra Double Strength Tocotrienols
Healthy Origins, Tocomin SupraBio, 50 mg, 150 Softgels
have been thinking about my reaction to DCA.
There was one week where i clearly improved (after the second week of usage), for the rest of of time I felt more or less the same (maybe its a good thing though). After the second week i had something like a herxheimer reaction (it was scary) and right the day after I felt a lot better, less pain for instance. i reported this above.
So i was checking what I did differently that week. All of this is speculative as i am marker negative currently but i have symptoms.
Overall, the only thing that i did that week and have not done since then is a fasting of appr 35-40 hours. Probably Dr Longo is onto something and fasting is really good at improving responses to chemoterapy/ drugs and improving your immune system. Its not a cure but I think it helped. So now I started another short fasting, 20 hours already left out 40.
Try it, its not so hard as it sounds. Ketogenic diet is more difficult.
Thank you for sharing that aspect, W.
I highly recommend you to look at phlorizin patent.
I read it everyday when i am bored and when i feel hopeless.I read every word of it.
Phlorizin is not only used with hyperthermia.Also alone or with chemo etc..
If you can make fasting,you should look at this.
And they use lonidamine there,it works like 3BP ,we have to ask it to Daniel.
thanks. The thing is that i can ‘t give anything intravenously.
Maybe i will need to learn but at this stage i am focusing on oral things. As i understood phlorizin is not helpful taken orally. If we could find a way to improve it (like pepperine works for curcumin: 20 times better consumption if you add black pepper or pepperine).
would love to add it… Any glycolisis inhibitor is a great help.
(empathise with you when you wrote you had a bad day because of the elections. I agree its disturbing!!).
This is not ANY glyco inhibitor.
I am very sure that noone has read it from beginning to end because noone is talking about it..There is a great knowledge there.
Fasting,chemo,hyperthermia,cancer cell repairment,necrosis etc…AND A REAL CURE.
Also there are SGLT inhibitors oral use but works like phlorizin.We are always talking about CA and metformin.
I am alone in this section unfortunately.I need really conversation about it or i am going to think that i am stupid!!!!
Yes Ergin. I am sometimes amazed when I get questions that would have the answer in the website, and could be found by using the search option on top of the page. Also Alex, recently said he never saw there is a drop-down menu option on this website, to select drugs based on the mechanisms of action. (Sorry Alex for giving you as an example 🙂 ). So I am wondering about how much people actually read the posts – they seem to be mainly focused on specific (popular) posts only.
too many problems 🙁 simply too many problems face me, and i know it can all be even worse. Seems like there’s no limit to all the BAD and Problems in life. There’s always the possibility of getting more problems and feeling even more bad.
I hope you and everyone here had a nice weekend and easter.
As for the example and the drop-down menu, it was a joke. Meaning that i did see it, i did explore the website.
Problem is, because of all the confusion, emotions, intellectually blocking feelings and problems, lack of education/experience, one can simply not know what is good and what isn’t good.
A person can read this entire website and if not faced with major challenges of any kind, one can lay back and get it all inside his/her mind with much ease and then think about it.
I admit i find it hard to function, i have lack of appetite, it got to a point where i no longer feel i can resist this, and it’s not me who is sick, it’s mom.
Somehow i feel i would have dealt with it better than she does, idk.
Anyway, here i am wanting to know more about cancer but not finding enough energy to focus on studying….
I’m still shocked and now more than ever i feel drained, i need a vacation far away from society and even mother.
But i won’t do that obviously, i will do whatever it takes…
I hope…… we have hope.
I love that Gallium idea, simply beautiful and i think it should receive more attention.
I read everything but it simply takes months to connect the dots together and understand anything. I know it’s been distilled but for me at least it’s too much, mostly because there’s the emotional side that seems to not allow me to “compute” as good as i would like to.
This is where i return saying that while i know you may not agree with this, we need a “ranking” system for treatments.
I know that many of them have not been tested as much as they should for a proper ranking system. However from a theoretical/anecdotal/personal experience/our experience point of view we could perhaps give it a “chance” of response mark or something… the usual 5 star.
Blood tests today… i’m quite confident the markers will be over the previous values. Still i hope for a nice surprise.
Mother has been doing some gardening, so it’s not all that bad.
Again i return to Gallium, i know she is anemic, the tests will include iron, copper, zinc levels too.
I find Gallium of great importance and i think it may just be an option worth exploring.
At this point i’m very tiered, but i will try my best.
Thank you very much for all the support, it’s all amazing. 🙂
Have a good one,
I agree its hard to oversee everything (not on the website – in general). this is why its good to have Daniels summaries like “best treatments” and the section D referrred to. But we cant focus on everything, and it seems everybody has his / her favourites. I have faith in keto+ metformin + DCA+ others just like meech.
I think most people comment to forums that are outstanding in a way (like CA for obvious reasons) or the ones that are “up and running” for other reasons. Maybe its just natural, the crowd effect.
Some weeks ago i found a very important post and there was like one comment, an offoptic one. So maybe we have responsibility for “bringing up” earlier posts that are important.
You are totally right.We have to talk about other treatments which is not popular these days in this website,and new links etc.
I am not against talking too much.I am happy to read all messages.
But as Pouya said,if a new patient comes here it is easy for them to lost here.
Alex said we have to rank treatments,is it possible?For me ,not worked,partially,worked .Than 0…5 or…10 points
It is impossible because we are not more than 10 people sharing results.
We saw a good result with iv DCA before chemo with Emad.What point will you give to DCA Alex:)?
I think if we see a good responce on any treatment,all of us will use it.
Now my favorite is phlorizin.Your favorite may be different.
May be using different protocols and comparing results is a good idea.
But there is synergism and also opposite.And cancer types are also different.
New patients and also old patients here can be lost easily because cancer is very complex.
I am already lost:)Because of that i will use phlorizin patent.They create a protocol,very good for us but i am sure they secret some knowledge there.
about me giving points to DCA before chemo working…….
I would probably not give points, i would say something like *tested & working for X cancer type*
And that information is important i think.
Because when you know what works and what doesn’t, you are not wasting time and money and also internal energy with stress.
Where were you?We miss you…
Today also adrenalin day for me.Blood counts!!!!
I hope tonight we both take good news.
hey Ergin, i hope the tests were neutral or positive. let us know.
Thank you very much for asking.News are not good.
TSH is getting higher so ca125 is getting higher.TSH:22 CA125:250
We need time.I am fraiding to see 500 in 2-3 weeks.
sad to read it – how much was ca125 last time and when was that?. Whats the plan of the doc?
sorry to hear that bro
usually markers begin to jump more and more whenever they get higher , but also whenever they start to fall , they will fall quickly
for me it looks like the progress in tumor marker is becoming slower, don’t be fooled by the increase in number
and also not like ca15-3 , what I know is that ca125 is less accurately
i had computer problems but they are fixed now + many other life problems at home or not.
GF leaving me for not being with her in months, i can’t be in two places at once, even if i could be in more than one place at once, i doubt i’d be able to have a normal conversation anymore, sometimes i forget i need to eat.
It’s all very dramatic and i am sure everyone is having a lot of problems of their own.
Work, love, money, health, etc etc…
I hope you come back with good news, i think more important are not the markers but how your mother feels.
I know this can be argued but that’s my honest opinion.
Did you get results Alex?
Wondering and you have to look at phlorizin post also.Dapagliflozin,canagliflozin.Oral drugs.
Yesterday we went for blood test, results come later.
just doing ! cheers
ok, finished reading the phlorizin patent, really convincing. I remember the cases were copy pasted to daniels article too. If i receive chemo in the future i would be happy to add it but i cant IV myself and i dont dont know any doctor who would this for me..here they only believe in the hardcore medicine. Any idea to improve absorption after oral use??? Cheers W
In short ,i will write for everyone,(especially new in cancer field) can understand easily.
Some Cancer types uses SGLT for taking glucose inside.
You can inhibit glucose entry into cancer cells with SGLT inhibitors.
When you inhibit glucose,cancer is killed partially by necrosis and also glucose inhibition makes the cancer cells sensitive to treatments.
They are oral drugs sold in pharmacies.Canagliflozin,dapagliflozin etc.
I wonder the dose and time needed for efficiency.How many hours should be taken before any treatments?
We need more researching.
Phlorizin is a dream,it is iv and,hard to make it at home but not impossible.
In the above link i sent ,the places where dapagliflozin reaches became nectrotic in mouse model without chemo.
If the tumor is small it reaches may be everywhere, micrometastasis may gone with those drugs.
Am i a dreamer:)?
Or may be not every cell of a tumor express SGLT?
i check the “….phlozin” pills in the article you linked.. thanks… !
Alex, re DMSO i need to educate myself.. .cheers
Anyone with feedback on DCA?
Combination of DCA and Salinomycin is synergistic in colon cancer cells.
Several of those on the thread have used DCA and Sal.
It appears that taken together they are even more powerful.
Mother passed away today at 9:44 am. Romanian time. 11 December 2018, 17 days early of her 61’th birthday.
Since i am replying to a DCA comment i will say that things need to be tried with serious caution and readiness to respond to complications should they arise, so planning is required.
Our story is one full of love, pain and a lot of medical details.
In the end, she would have died yes, however i think she would have lived to turn 61 and maybe get across to 2019 if we didn’t go for anti PDL-1. Nivolumab monoclonal antibody opdivo. and many other complications caused by many things.
I have no regrets, i look in the mirror with no remorse, it’s what she wanted to do, it was our last fda aproved drug to take, our final option. She felt great about trying it, so i did my best to ensure she get’s the chance to take it, so she did.
I am proud i helped my mother all this time, giving her a longer life and a much better one had i not been there for her.
We were warned, but knowing the end was very near, we went for the last thing to try.
I had the chance to talk about so many things with her, i had time….
Perhaps i should have eased up on my efforts to get her well and maybe spend more quality time with her, however i went ahead with hope that time will be available, thanks to Daniel’s kind words out of experience, i did my best to ballance and i feel i did well.
I did my absolute best to ensure she has everything she needs to the best of my abilities and i had help. Yes most of the times i was alone with her, but i was helped when i screamed the most.
SHe was a worrying kind of person, but thanks to me and all the help i received, she didn’t need to worry about anything anymore.
I abandoned myself so that she can live, and i don’t regret it at all. I tried…. i could have succeeded, one can never ever know for certain.
I was next to her, till the absolute very end, as i promissed her.
Now it’s time for me to recover and then honour her life and tell the story, help others, share experience.
I have to make her proud, maybe get married and have kids, something i wish she could have whitnessed for herself, grandchildren
Thank you very much for all the help
I need a vacation….
Alex, my deepest condolences. I am so sorry to hear that … with everything you did for your dear mom you showed you loved her so much. You did everything you could with the heart full of love for her and that is the essential in life.
Please take good care of yourself and whenever you like to speak, please send me an e-mail and I will come on Skype.
A big hug!
Sorry for your loss.
@Alex: I am very sorry for your loss. Fighting advanced cancer is very hard, even when you have access to the latest drugs. When you are limited to public health drugs, it becomes even harder.
You are right, there should be more awareness about the adverse effects of the anti-cancer drugs, how to detect them early and how to manage them.
I thought about writing something on this matter, but this is more linked to clinical practice than to scientific research, so it
probably wouldn’t have been helpful.
Thank you Ovidiu for all the help.
Dear Alex, please accept my condolences as well. you and your dear mom were always in our thoughts.
take care my friend.
Thank you Pouya, thank you for being a friend.
Glad to see you around still, as for mom, she died fighting.
I would have been more around here if things were not so difficult.
Paralisis, cancer, being the only one caring for her, having to deal with papers, treatments, and money and so many more things all at once.
It’s time for a vacation. Can’t wait for summer and the beach, me and my mom loved it there. I’ll visit old places, i will regain myself, and i will find new roots, next to old ones.
My heartfelt condolences Alex, I’m very sad to hear this news today 🙁
Please stay strong
Thanks to you here, more than 2 years ago, i gained courage to fight the monster, like you i was naive to think i could win.
Daniel and Ergin, but also the others gave more hope to us, in times where there was none.
Hope, is the thing that drives us towards the next day, to fight another fight, one more round. Do we fail or not? Most likely we fail, but it’s not the end that matters, it’s the path we walk, the things we do, and the things we will always remember.
So do your best to remember your mother and the path you took. Not to feel sorry for not doing one thing or the other, but to be proud of having done more than anyone would have done.
I look in the mirror and congratulate myself. Yes i have failed, but it was not to be. I know that because, there was nothing else one could have done. Maybe 50-100 years from now they will laugh when they hear about cancer, however, nowadays, the reality is that, it’s out of our control. We are only toying around, while some get saved, still so many die.
My humble opinion only. With all this science and all this talk and talk, it’s all a throw of the dice still.
I feel we’ve been lucky, but luck has to end eventually. It’s not me who dictates it, it’s the way the universe works.
Would i love to change how things work out? would i love to end all problems? Yeah!!! Am i only human?! Sadly yes.
But a great human. Still not enough, i am limited.
I hope my thoughts bring you some peace of mind as well, maybe even Ergin, if he is reading.
Take care and maybe have some fun?
Alex, my deepest condolences.
We have all been called to fight this monstrous disease.
It is almost as it falls from the sky and into our lives and it is such a mystery: Why us?
Through this virtual forum, people from all over the world have taken up the challenge
with the sincere wish that they can make a difference for others.
You did everything in your power to make that difference for your mother: No more than that can be expected.
Alex, you have helped all of us in this journey and I hope that our posts have been helpful for you.
Sending you feelings of love and compassion,
What of a combination of DCA with LDN?
I wanted to use it before , until now I didn’t find any information about possible interference between both of them
not sure really
I found it interesting, and it offers hope?! Yet another “thing” on a growing list.
So far there are MANY things that are scientifically backed more or less to be anti-cancer by some way of doing so.
The questions that come to me now are, how many should be incorporated? As many as possible right?
Would the disease have a chance to progress? Very slim it looks to me.
So i think that perhaps we should make a BIG list of everything we read, heard about and try to put together the strongest most effective treatment, but first looking into compatibility, synergy things like that.
You know… hit this thing hard and with a vengeance. (so…?!?! you like my videos ha? https://www.youtube.com/watch?v=MVbeoSPqRs4)
Anyway, i think that if we hit hard with everything at once we may have a day of days!
A strong push with our concentrated “army” all in & all focused and then sustain that for long enough, 1-2 weeks then ease down maybe.
looking at how LDN is supposed to work, i dont think there is any interference with DCA.
Thank you very much
Emad, glad I found you here, I have been thinking about you.
There are so many things to be worried about and brain mets are another to add to the list.
Brain mets would probably even top the biomarkers in terms of importance.
After reading about POH and the success they have had with brain mets, it might be a good idea to have them on a shelf.
Perhaps you could ask Medicor about them, see if they have the combo of POH and temzo or others.
This POH angle might even be a good one to try preventatively.
For those who do not know POH https://www.cancertreatmentsresearch.com/perillyl-alcohol-poh/
Reporting in on DCA.
It would seem that my mom’s response to DCA is good. Perhaps too good. As pain levels only lower with DCA dose lowering.
I sense a major risk so we will lower to 1500mg/day. This is to prevent any possible short/long term issues, heart attack, stroke etc.
The other pills and things she takes and does only worsen the pain instead of making it go away as they once did.
I attribute the response this time after 1 week of DCA at 2000mg/day to removing Citric Acid and chance… if there’s such a thing.
Lacking any serious side effects we decided to not stop after 2 weeks of continuous administering orally of 2000mg / day.
In this video https://youtu.be/9o12uT_d-Co the appearance of pain is associated with good response to DCA.
Obviously there is a place for mistakes when saying this. We’re very excited as this COULD be the good we always hoped for.
Thanks Alex, I am glad to hear the pain is lower at the tumor site as you reduced the dose of DCA. That is also interesting, I must say. The fact that pain at the tumor location depends on the DCA dose may be a good sign indeed.
Did a bit of testing from day to day. Now that she didn’t take her Diner time DCA, she still feels great pain but not like yesterday.
Obviously if this is true that the pain is caused by an impressive response to DCA, the dose should be lowered in order to also lower the risks involved with tumor shrinkage. (being optimistic here – no tests made yet – tests may also prove inconclusive).
I am glad that you also find this interesting.
Hi Alex, I do think may be interesting and that we should expect the best, but I also strongly suggest to keep in contact with a medical doctor and have a look at what happens (blood and imaging) if possible. Kind regards, Daniel
Blood and imaging – as soon as possible 🙂
i dont know in what overall physical condition your mother is but im sad to read about her pain, especially if its related to cancer.
If she has a normal weight you might consider fasting of 1-2 days after a day with some stronger meals. I have constant mild back pain that gets better after fasting, and DCA seemed to work better when I fasted 1-2 days before. I tried it 2 times and symptoms were better both times. Of course this might be placebo but i doubt (see above).
Maybe worth a try but be cautious and consult with a doctor before trying this as your mother is older than me….
Re the science behind, pls refer to dr longo.
some weird coincidence
after 40 hours of fasting my pain was a lot milder ( fasting is anti inflammative) i stopped fasting as planned
Then I took DCA + chloroquine + supplements and i started feeling worse, my back pain was 3 times more intensive for the whole day. it never changed so much within a day.
i dont know how DCA anticancer effect could lead to pain, – i saw mr khan’s comments that some patients feel pain near the tumor in the first few days, but for me it was coming later…
Looking back, i might have had this a few times, but the effect was smaller and i did not connect to dca.
i really hope it does not mark progression & inflammation ….. i dont take dca for a few days and see what happens.
We tried Aspirin, that ALWAYS reduced pain in the past. These days it only makes pain worse.
my mother had some pain when she started on DCA for the first 2 weeks , at that time she had a very very good respond to the chemo + DCA combination
Very interesting this association of pain, good response, results.
Perhaps returning in some way to those same conditions and sustaining it, may bring consistent results once more.
i stopped DCA for a few days now and my back pain is clearly better. might be a coincidence. 🙂
Has someone readed about this ? Both of them under hipoxic condition:
Hi Jandro, is difficult to understand these results. I can understand why in hipoxic conditions DCA will work less as an anticancer, but to amplify that it would require oxygen (in my mind) which is not the case in hipoxic space. The same is the case for other glyco inhibitors, i.e. less effectiveness in low oxygen conditions https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694858/ Anyway, when I find the time I will have a closer look at these and similar studies.
I may understand this very wrong so i ask some questions because you understand the cancer cell better.
If Acetate is the fuel when sugar is not around, DCA has acetate in it.
If HCA is meant to prevent Acetate from being used as fuel shouldn’t we avoid HCA when on DCA?
A little confusion here, sorry.
HCA is not meant to prevent acetate use. It is meant to inhibit the conversion of Citrate into AcetylCoA https://www.cancertreatmentsresearch.com/another-weak-spot-of-many-cancer-cells-atp-citrate-lyase-inhibition/
If acetate is used, then Acetate will be converted in AcetylCoA https://www.cancertreatmentsresearch.com/acetate-fuels-cancer/ so we will need to inhibit this conversion (inhibiting ACSS2), and or inhibit acetate import via MCTs and/or at least inhibit conversion of AcetylCoa in Cholesterol using Statin, as discussed for example here: https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/
Thank you very much Daniel for your reply.
The reason i ask is because i know that Acetate is in DCA and i remembered your referenced article about Acetate fueling Cancer when other fuels are not available or it does this at the same time.
So i wonder if DCA is working, than perhaps it also does so by fueling the cell but tricks it that way into releasing the Chlorine molecules.
Maybe i’m going too far again.
It may explain why it’s synergistic with diet, metformin, diclofenac, aspirin, hca, b1, ala, statin etc.
It may be that DCA works in more than one way against the cancer cell, this obviously would not be new to you.
I am trying to learn myself.
Thank you very much for everything.
This brings Apple Cider Vinegar to my mind.
Could it actually work? Would this be the poor man’s DCA?
i think poor man’s DCA (or maybe rich mans DCA?) is ALA – works in a similar way and is less toxic. I dont know if it works in _all_ the ways DCA does.
So is vinegar sinergistic with DCA or not?
i hope i am not oversimplificating things but vinegar seems to be antiglycemic so it should fit any cancer therapy with or withour dca.
how is your mother?
La différence entre DCA et ALA c’est que DCA augmente la production de ROS déjà surexprimé dans les cellules cancéreuses, comme la chimiotherapie pour déclencher soit l’apoptose, l’autophagie ou la nécrose des cellules cancéreuses. ALA au contraire aura tendance à ramener la production de ROS à son seuil normal comme dans une cellule saine, avec donc déclenchement d’apoptose si la cellule détecte une corruption de son DNA. En fait la surproduction de ROS , au premier palier va entraîner une corruption de DNA (état cancéreux), au palier suivant on a l’apoptose, puis l’autophagie et ensuite la nécrose. Donc avec la chimiotherapie, comme DCA , on détruit des cellules cancéreuses en augmentant leur production de ROS, mais à côté on transforme des cellules saines en cellules cancéreuses en augmentant leur niveau de ROS au premier palier.
D’où la résistance aux médicaments avec cette méthode.
Avec ALA on n’a pas cet inconvénient là !
“The difference between DCA and ALA is that DCA increases the production of ROS already overexpressed in cancer cells, such as chemotherapy to trigger either apoptosis, autophagy or necrosis of cancer cells. ALA on the contrary will tend to reduce the production of ROS to its normal threshold as in a healthy cell, thus triggering apoptosis if the cell detects a corruption of its DNA. In fact the overproduction of ROS, at the first level will lead to DNA corruption (cancerous state), to the next level we have apoptosis, then autophagy and then necrosis. Thus, with chemotherapy, such as DCA, cancer cells are destroyed by increasing their ROS production, but at the same time healthy cells are transformed into cancer cells by increasing their ROS level in the first stage.
Hence drug resistance with this method.
With ALA we do not have this inconvenience there!”
thanks Malypaet. where is this text coming from? from you?
if this is true these 2 compounds are not synergistic at all…
Malypaet has a very good point. There are some publications indicating that ALA acts in a similar way as DCA shifting pyruvate to mitochondria. However reading carefully this study I realize that this is not totally clear https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3542233/ and that is a hypothesis. There are a few more studies on this line that I need to read when I will write a post on ALA.
However, what is clear is that ALA is one of the strongest anti oxidants that I know of with the capability to scavenge a variety of oxygen species. It is not only a theory to me but also have seen the action of ALA in real life. Too much to explain, but it can indeed stop the action of 3BP or chemotherapy.
Yet, I do not see the oral form as having very strong action unless it is taken in very high doses. So I would even take it orally in small doses to protect the liver and good cells even if we use pro-oxidant treatments. But the IV form it is a very strong anti-oxidant and I would certainly avoid to combine with pro oxidants such as chemo, 3BP, DCA, etc.
I also mentioned this point some time ago in the comments above https://www.cancertreatmentsresearch.com/dichloroacetate-dca-treatment-strategy/#comment-2013
As we see, any drug and supplement has multiple targets. To make things simple, I would always check for every drug or supplement to see what are the most relevant known targets and that is what I would follow. Same with ALA.
Thank you. Interesting. I ran out of hca (i take hca plus ala), i only take now 2g ala on top of DCA, ldn, chloroquine and supplements, maybe i should stop with ALA.
DCA and ALA fall into two opposing strategies, DCA acts by citotoxicity like chemotherapy or radiotherapy, ALA acts by bringing the cells back into their normal operating context (normal ROS level for example). ALA is often taken to correct the neurological effects of DCA, but as part of the cancer their actions cancel each other out, so avoid taking them together. When it starts with an anti-cancer treatment citotoxic, after a certain time it will have to be interrupted before it becomes too harmful for the healthy cells and give the relay to the immune system supported by supplements like ALA, HCA, curcumin, vitamin C, etc.
That is the best strategie, as said Guy CORNAUD in is book “Rebirth”
He said this evidence :
When you cut, you will clean the wound with a disinfectant, but then it is your own body that will operate the wound healing.
my mother has been on a 3 day break from treatment, her pain eased down.
even more interesting, diclofenac was actually able to kill the pain, where in the past it never ever did that, even recently.
Aspirin, metformin only made the pain worse when no diclofenac was taken. in the recent past they would ease down the pain, not make it worse.
I am worried about my mother’s future health since DCA is pro oxidation
Then again, it could have been worse, actual chemo.
Pain seems more local
my mom also started the budwick mixture in this 3 day treatmen pause
i don’t know what to think of it in combination with DCA and ALA, HCA
if one should be removed or lowered.
Alex, I revomed ALA for a while based on above. I hope HCA is effective without it. Maybe you can keep for the DCA pauses for your mother.
it may be that you are also having a response from DCA treatment without ALA.
the removal of ALA is new so I cant comment on DCA without ALA yet- will keep you posted. Neuropathy might be stronger for sure without ALA.
“Alpha-lipoic acid (ALA) has both antioxidant and oxidant properties.”
Successful use of DCA and ALA on cancer patients:
Regardless of what this article is suggesting, ALA is one of the most powerful anti-oxidants and I would never combine it with chemo. If you search in the scientific articles enough, you will find literature to support almost anything (including ALA as a pro-oxidant). Beyond the science that in its majority indicates ALA is an anti-oxidant, as I mentioned several times on this blog, I’ve seen it with my own eyes on CT scan how ALA application saved tumors exposed to pro-oxidant therapies.
I like ALA as stand alone – it has its own anti cancer benefits – but never in combo with pro-oxidants.
I agree with you in that ALA should not be used with Chemo or radiation therapy. It would also make sense to not use ALA with DCA. But seeing case studies with ALA and DCA had me puzzled. I made a post in the DCA group regarding the combination of ALA and DCA. One person responded that her husband is using ALA with DCA and is currently NED.
ALA increases glutathione which should be lessened during chemo but DCA is a prooxidant and killing agent so I don’t understand how ALA is working with DCA.
My reply was regarding ALA with DCA and I agree that ALA should not be taken with chemo/radiation.
The https://www.dcaguide.org/ website also confirms this with this statement for ALA:
“do not take with chemo, wait 1 week after; do not take with radiotherapy, wait 2 weeks after”
But they say ALA is a must with DCA.
The ALA is used to prevent neuropathy but my question is wouldn’t Vitamin B1 be sufficient to take care of the issue of neuropathy.
1. You mentioned about a person using ALA and DCA and being NED – is he NED after using this combo or is using this combo while being NED?
2. Every substance has multiple targets. From a scientific point of view, two different substances may have some targets that lead to antagonistic activity and at the same time some targets that lead to synergistic activity. Now, the questions is which are dominant and most relevant in a given person and context.
For example, ALA and DCA are working in opposite direction from anti/pro oxidant point of view, but they work in the same direction from activating mitochondria and leading to accumulation of citrate, reduction of glycolisis, and reduction of lactic acid export which in turn may lead to increase immune action and less friendly microenvirenment for tumour expansion and metastasis.
Depending on our situation and all other therapies we like to use, we can decide if we want to combine ALA with DCA or not. Both make sense depending on the strategy we chose.
I have advanced ovarian cancer. I had carboplatin treatment late last year, but became resistant half way through. My CA125 came down to 90 (from 3500) but now it is back up again and I am being offered weekly Taxol and Avastin which I am considering.
I have been taking LDN, DCA, Metformin and Lovastatin for a few months, but it doesn’t seem to have worked. I have also been taking ibuprofen and quercetin at night but I have read on your site that is wrong – plus HBOT. Can you tell me what drugs you think I should continue to take during the chemo? I don’t really want to have chemo just now, but I am in a lot of pain and can’t think about anything else.
I really want to get into remission, but am not sure what road to take. I am looking at the nanoknife and surgery, but I think my tumours are too big and scattered for that at the moment. If you have any ideas I’d love to hear them. I have just found this site and it is so informative – thanks so much.
I remember ovca was mentioned as a responder to low dose naltrexone. I also remember that dca resentizes cells to cisplatin and carbopl.
There are some nuances to that W:
LDN can both inhibit or fuel the tumor growth depending on its type. LDN is a TLR4 antagonist and:
“These results have translational relevance, demonstrating that TP53 mutant breast tumor growth can be suppressed by pharmacologic TLR4 inhibition, whereas TLR4 inhibitors may in fact promote growth of TP53 wild-type tumors. Furthermore, using data generated by The Cancer Genome Atlas consortium, we demonstrate that the effect of TP53 mutational status on TLR4 activity may extend to ovarian, colon, and lung cancers, among others, suggesting that the viability of TLR4 as a therapeutic target depends on TP53 status in many different tumor types.” http://www.pnas.org/content/112/25/E3216.full.pdf
I expect TP53 status can be checked with chemosensitivity test that should be accessible to many.
Also, if the tumor (in this case of breast) will not respond to chemo it is likly that is of wild-type: “We reported that TP53 mutated non inflammatory locally advanced breast carcinomas had a high rate of complete pathological response to dose-dense doxorubicin-cyclophosphamide chemotherapy, while TP53 wild-type (WT) tumors never achieved complete response.” https://www.ncbi.nlm.nih.gov/pubmed/24074787
This means to me that if the patient used chemo and did not achieved remission there is a good chance that LDN will even promote tumor growth, at least in case of breast cancer. If that is the case, we could try TLR4 agonists such as Immunomax (see one of may previous posts on this vaccine) instead of TLR4 antagonists like LDN.
I should write a post about LDN to create awareness about the above.
I understand that for this channel LDN is a double edged word but i presume it impacts cancer stronger via the opioid system, Will doublecheck.
I agree W, but we need to have an eye on that and if we still see growth while on LDN we may want to switch to TLR4 agonists.
Thank you for your comment and I am sorry to hear about the challenges you are dealing with. First I should say that I and other friends here, can think of some ideas but please read the disclaimer on this website + give us some more info on your previous treatments + your country (to think of some clinics) + tumor locations and where are the dangerous ones (to think of local treatments) + the flexibility of your doctor to help you with any ideas we may think of, including re-purposed drugs. Have you read my post on T4-deplition strategy https://www.cancertreatmentsresearch.com/induced-hypothiroidism-hypothyroxinemia/ and Ergin’s reports on experience with this treatment strategy?
Reporting that we have restarted the dca focused treatment after about 3 days of break
During that 3 days interval, the pain levels dropped significantly overall.
Now that we restarted, levels went up again, diclofenac is able to kill the pain, not unlike the recent past when it did “nothing”.
the thing on my mother’s arm is changing from day to day in size less,but in fullness the most, hard, soft.
Marker values are increased sadly.
However the rate of growth is decreased. About 50% slower.
Pain persists and diclofenac works to take it away.
Our first Neuropathy day has come. That took a while. DCA was restarted on the 24’th last month.
We decided in the past that if cancer doesn’t take a break, we shouldn’t take one when treating it.
It would seem cancertutor has an article about DCA now.
Not sure how long it’s been there but the site seems to catch up.
I hope this comment will swing some of their reader’s attention here where i feel there’s much more value to have and offer.
As for me and my mother….. i hate to complain in here. We are down in too many ways.
Decided to flip the coin to anti-oxidants in hope of reducing neuropathy and inflamation
Fish oil, Germanium. Apigenin, Resveratrol, ALA, Ginger, etc…….
have you seen my comment re egfg inhibitors working even for lepto??
How about trying Artemisia again? You said your mom tried it as a tea but it appears from Daniel’s article that hot water seems to destroy the effect. My mother now just soaks the dried leaves in lukewarm water. She says the drink is quite bitter so it must be working.
Also, you could make the “Avemar” very easily, by adding yeast to dried wheat germ (if you can buy that at the local supermarket, very cheaply) and water and ferment it in some warm place. Avemar is known to work for cancer!
Are you going for the steroid shots as W suggested you do? How is your mom doing?
i have but that price…. those side effects…..
i dont know your budget after so many drugs and supplements but below site offers the drug at a reasonable price. Please mind that i have never ordered anything from them so i dont know if they are reliable. They say the are US based but I i suspect they are from India with just a US domain as they answer in their online chat in an “indian way” ( i recognise their grammar mistakes as i worked with indians) and they admit that the drugs are from india. I checked on scamadviser and there were no reviews.
appr 4 usd per day.
Re side effects, I think its pretty average or better than that compared to other cancer drugs. If you read the side effects of an anti malaria drug like chloroquine those are more scaring. It is a gene inhibitor.
I think its worth considering – as lots of adenocarcinomas overexpress and mutate EGFR for their growth.
Alex, how are things ?
Very bad sadly.
I’m changing diapers…. getting ready to be a successful dad and husband, for when i actually get to not be single.
Still i hope for better.
My mothers appetite returned today,
I’m going with anti-oxidant detox supliments
Just did her first B1 Vitamin shot, looking forward for her to be able to walk again.
Still fairly confident it’s from the DCA and optimist a bit.
DCA side effects -> Be afraid, be very afraid!!!
We have it stopped since the 24’th-6th-2017
It looks like i know more things than my family doctor……. in experimental oncology anyway.
Went there for customs prescription in order to get the meds from ergin for t4 depletion that were sadly not to be found in near-by farmacies. Getting them tomorrow.
Pain is still there and can be managed with diclofenac.
Thank you very much for everything.
Without everyone here, i don’t know how much worse the situation would have gotten in all this time together here.
Our best wishes,
Alex & Mother!
Alex , when is the next CT Scan ?
My heart is with you man , you should always feel positive
wish you a happy life
Thank you very much.
Sadly i don’t know when we can go for a new scan with my mother fixed to the bed.
We had that schedduled for yesterday.
i must first help her get out of it.
B1 vitamin, very uncertain.. her feet swelled up instead of getting better
I wish i knew what the solution is.
Neuropathy persists in her fingers too…………..
She can’t get out of bed without me helping
At this point i’m clueless. Got a house full of meds and nothing seems to do much good.
Her spirit is very low as is mine and she is rejecting everything at this stage.
It’s all so hard, my worst nightmare, made real.
She suffered so much all her life, it’s so unfair.
We are all good people, too much suffering everywhere.
I don’t know what more i can do when she rejects almost everything and nothing makes any sense anymore.
It’s out of control, still i hope….
Thank you for everything,
Can I suggest “drinking” the calories when the appetite isn’t there?
If you’re following a keto diet, fats are extremely high in energy content. One tablespoon of olive oil (or most other kinds of oil) contain 100 calories of basically 100% fat. If you can mix it into a smoothie with some peanut butter (mostly fat, also 100 calories per tbsp), and maybe almond milk and a few raspberries, it won’t taste horrible and it might be a way to improve her energy and nutrition.
Thank you dear Meech,
These days i don’t know what to focus more on. I’ll try to keep her hidrated, nourished and i hope to somehow be able to get her on her feet once more as a priority, because without that, i fear we won’t be making much progress at all.
Thank you very much for everything,
What is it that’s keeping her off her feet? Pain, exhaustion, blood pressure, or physical disability?
neuropathy, unable to control the legs
Sorry to hear that, Alex. Hope you can keep the spirits up.
my mother did feel the same 12 months ago
a very bad neuropathy that made her so hard to stand or move , she was barely walking at that time
but the doctor used to medically treat her , and after a while , she begin to walk and move easier again
it took sometime , its not a problem that we can solve in just days
Alexi hope its just from DCA. try take b1 and alpha lipoic Acid, both of these are improving nerve issues induced by medications and would do no harm.
My tumor marker AFP decreased from 4 to 3.3 since starting DCA in March. Both normal (<7) but i like the change. Of couse i dont say its attributable to what i take but 2 months after chemo it was still 5-6.
No sign-of tumor on CT. Neuro symptoms & back pain still there but milder than in March when i started taking below supplements / drugs. Doctors still dont know why i have these, i am arranging another Lyme test after the first one in September. Still thinking it might be cancer as i never had neuro or back issues and chemo should affect CNS.
I take now artemisin annua (just started), genistein (just started), garlic extract, vit D & E, curcumin, citric acid, Melatonin, DCA, LDN, omega 3. Liver functions better than before.
Stopped ALA + HCA not to mess with dca.
hopefully i report good news in 3 months too.
auto corr; *chemo should NOT affect CNS
Are you still on both citric acid+DCA?
Yes, I know there were some concerns on the compatibility but I have the feeling (subjective i know but how could i verify?:..) that both help. Even if they are counteracting in one aspect there might be other ones in which they are complementary .. for example following link claims that DCA restores Citrid Acid levels in cancer cells making them more vulnerable to chemo and apoptosis;
i can say that we did ca and dca,
sadly there was no change with them together.
There was a small change with just dca.
when i stopped CA for a few weeks i noticed a pain increase. Then I restarted and it was weaker again. Now im ok. Maybe it is not related but i decided to keep CA.
I also noticed that anti inflammative supplements like garlic and curcumin make me feel better.
I really dont know anymore what s happening.
I would suggest that inflamation is an effect of DCA actually working. That was when diclofenac was effective in stopping the pain.
when we did both, DCA did “nothing”.
Obviously you should do what you feel is best, but i would check markers and increase rate/day to be able to somewhat determine if the combinations are indeed effective.
Always great to hear good news.
Thanks for the update W. Great to hear about the trend!
Good to hear that W , I’m happy to hear that 🙂
Hi. I got my mom diagnosed w stage IV pancreatic ca. a month ago. Started IV Dca treatment two weeks ago. Very optimistic. We are not.doing convencional tx due to poor prognosis of the same treatment. Also started with strict keto diet combined with 10% quemo. I found one clinic in us to administer iv dca. Wondering if there might be other locations in us that will provide iv dca?
Not sure about iv DCA locations in us, medicor in Canada i know of.
Re pancreatic please read about dr berkson and his protocol too.
Unfortunately, Medicor and a couple of South American clinics are the only ones who provide I/V DCA therapy as far as I know.
You could also just search for “DCA” on amazon, order it, make the I/V bags with the solution yourself.
I know it’s not wise to advise something that should be done on medical supervision but there is plenty of information how to make I/V infusions
by yourself. Clinics will administer I/V DCA and charge quite a sum for it, so your only bet is to try administer I/V DCA yourself.
The biggest problem is that you don’t have the information on what concentrations you should administer I/V DCA, though there is information about it on the internet.
You can also try and order a consultation from Medicor cancer through e-mail for a couple hundred bucks and ask them how to achieve such a goal.
You van find the answer to how much is given in the clinics in how much NaCl and during how much time, in my post on this page 🙂
Some time has passed now and i’ve long pondered. Still very uncertain but will finally write about it.
I strongly believe that DCA was doing it’s thing for mother, however due to the location of the tumor, when the tumor was decaying the immune system began to swell the area, causing inflammation in response to the “foreign” tissue.
This description of what i believe happened may be inacurate, still i see the swell on her spine scan and the cord is “pumped” in that specific area where it comes in contact with the tumor, it is my honest personal belief that the swell is caused by some kind of reaction that would have possibly ultimately lead to my mother’s tumor shrinking if not going away for good.
Next to the swell there , her left arm had a enlarged lymph node that did grow larger than what we saw previously when the DCA treatment began to do it’s thing.
We felt it was time to stop and go to a professional oncologist due to her “neuropathy”, after all this time it should have gone away, still she is paralyzed, unable to walk, stand, and pretty much do anything alone.
I’m changing diapers, emptying the urine bag, and so many other things like that. – I wish i had more time to be around like before.
Changing bandages for her escar, i’ve bought her an anti-escar mattress, alternating air chambers, a wheel chair.
I can only feel so lucky for real and ironically. Life is not without a sense of irony.
For real however because i’ve been helped so much, i’ll eternally be thankful.
Ironically because, how does one even begin to feel lucky being in this situation!?
Back to treatment, my mother is doing chemo these days at the hospital, she’s been taking Tarceva for more than a month, some neuronal recovery is being noticed, she can feel her chest again. And tumor related pain is almost non-existent since starting the drug.
Meanwhile she’s been taking pro-biotics, vitamins, been trying to keep her as well fed as possible without feeding the beast as much.
Out usual Metformin is with us next to those.
Since i felt and feel i’ve done enough damage, i’ll do my best to try and talk to the doctor about some of the articles here.
It’s been about 3 months since my mother stopped walking, and also since she started “official” treatments. Should the doctor reject me, i’m guessing i’ll be forced to try anything only as a last resort.
It may be possible that she will choose to combine chemo now with radiation and maybe will also choose to do a scan now instead of allowing another 3 months to pass.
I’ll be back with more news.
In conclusion, it is my honest personal belief that DCA deserves a true chance in more research if needed, if not, implementation but only at own risk or helped by a professional, to avoid complications or life-risking side-effects.
I’m starting to honestly look more towards life quality as a priority since aggressive late-stage cancer is almost impossible to “cure”.
(This organism is the very essence of life in the universe, the expression of adaptation to entropy, eternally changing, always surviving, regardless, without it, we would not be here, it doesn’t go away easy because if it did, life itself would not exist).
And DCA can potentially be used to obtain a better quality of life, for those few if not many that would probably benefit from it.
Obviously other basic drugs/suppliments should be used next to DCA, and thankfully reading this website offers plenty of choices.
Apologies for the long “love letter”. – I feel this one did not waste your time dear reader.
Hi Alex, please remember that recent studies suggested not taking Metformin a few days prior to chemo. This is because Metformin is slowing down the cancer cells. That is good but it makes chemo less effective since chemo is usually working best against fast dividing cells. The study also showed that if Meformin is stopped prior to chemo and started during the same day with chemo, the anti cancer results were even better compared to chemo alone.
I wrote this point before but want to make sure you are aware of it.
Thank you for reading my comment and replying.
I have not forgotten your point made in the past while having a skype conversation together.
Last time she took metformin at the same time the iv with chemo was being performed.
Would there be a better timing for taking metformin?
Thank you very much for your help and concern.
I’m wondering if you would agree with the following.
No more pills before chemo for a few days, except Tarceva.
Then chemo is being performed, allow for about 6 hours to pass.
Take Tarceva 150mg as usual and then (Aspirin 750mg, Metformin 750mg, Lansoprazole 30mg) – one time at those dosages
Then continue with Metformin 500mg once or twice a day because my mother’s energy is not what it used to be.
Something i’m missing?
Much appreciated and eternally thankful.
Can someone please direct me to a reliable source to buy DCA? there are many websites that sell it but not sure if they these websites are genuine or the stuff they are selling is actually DCA instead of just white powder. Thank you so much in advance.
I live in New Zealand by the way.
I ordered from here : https://pharma-dca.com/buy_dca/
if i remember well, it came from the UK. it was posted right after my transfer.
it was definitely DCA ( i can not test purity of course…)
the price is lower than other sources that i have found.
My dog who’s 8yrs old has lymphoma. His sister passed away last year from lymphoma after failed success with chemo.
I have him on DCA and LDN adding B1/Benfotiamine as needed. I don’t have access to Metformin, but understand that Berberine is very similar.
Would Berberine have a similar effect as Metformin in increasing the effectiveness of DCA?
Would there be an added benefit of including Omeprazole as that’s readily available?
This post has been very helpful, thank you all for contributing.
Please search for this.
Also i know people using it here,and waiting for the results.But i heard that it works petfect on dogs.
DCA makes colon cancer worse: https://goo.gl/pzLYR3
3BP have not such problem. I don’t know if there is more stable alternative.
I have a question. We bought DCA for dad, for an oral intake. He is currently under folfiri. I can not decide whether it is better to take DCA at the same time as chemotherapy or a few days apart. In some reports it is said that dca can increase the efficiency of 5-FU for example, but in other reports it is said that they have spaced at least two days apart.
Thank you very much to those who can help me.
By the way, I wrote two comments in another topic recently and my post was never published. 🙁
I am sorry your comment was not published. I haven’t seen any waiting for moderation so probably there was some automatic filtering. Is possible that your comment was not on the articles I write but in the forum? Lately, when adding a comment in the forum, that contains a link, leads to an automatic rejection. I had the same problem. I contacted the support from the plugin I use for the forum and I am waiting for response to solve this issue. A workaround I found is to create a comment/topic without a link and after that push “edit” the comment/topic (every comment/topic in the forum can be edited during the first 5 minutes) and add the link. I am sorry for that and hope to solve it asap. However, when adding a comment in the typical articles I write, like you did here, there should be no problem and your comment is automatically published.
Regarding your question, I would use DCA in between and not during the days of chemo. While from an intracellular mechanism point of view DCA should help chemo due to the pro oxidant nature, from an extracellular mechanism point of view it could reduce the effectiveness of folfiri. That is because both 5-FU and Irinotecan seem to be better absorbed in an acidic environment:
DCA on the other hand is expected to increase the extracellular pH due to it’s mode of action (reducing fermentation) and in turn possibly lead to a lower absorption of folfiri.
Once Folfiri is absorbed, DCA should help since they are both pro oxidant. As a result, I would indeed use DCA the days after chemo but not during.
I hope this helps.
Could you please share the link to those suggesting to use it a few days apart from chemo? I am curious to see what are their arguments. Thank you.
Thank you very much, Daniel !!!
I also wonder if we can take procaine orally (to increase the effect of Dca), do you have an idea by hasart, I saw that we can find in the form of powder procaini hydrochloridum ..
My father is on anticoagulants (innohep), because he made a pulmonary embolism at the beginning of the year, I hope that the combination dca – innohep is not dangerous ..
Here is the link to an article in which they say “Infusions have been planned around chemotherapy infusions (separated by at least 2 from chemotherapy) to avoid any potential interference or drug interactions.”
Regarding my comment, it was on “Drug cocktail could double the average survival time “, I got a message of the style “waiting to be approved”. I tried again a few days later and got the same message. I don’t know … maybe it was me who was wrong in something, because indeed now my comment was automatically published ..
It seems these spam filters work a bit randomly …
Regarding your question, I think is best that you contact
Akbar Khan, MD, Medical Director, Medicor Cancer Centres Inc., 4576 Yonge St., Suite 301, Toronto, ON M2N 6N4, Canada. akhan @ medicorcancer.com
He is one of the most experienced in the world on DCA, and probably encounter a similar situation and should be able to give you a good advise.
If there is no response from him please let me know and will do a research on the subject.
Is this a good idea?
Yes, Daniel. The exact message that appears is “Comment awaiting moderation” 🙂
Thank you so much for these coordinates! I will prepare a little e-mail tomorrow.
Best regards and good night.
Mom took 1.5g/ day no other treatments
CEA Dropped but CA-19-9 grew
Take caution, talk to your doctor before anything.
After stopping DCA the effect doesn’t go away fast, it takes time, depending on how much time it has been taken for.
DCA builds up in the body. https://youtu.be/8uY3bfU3vG4
DCA is very interesting from a scientific point of view, however don’t bring your surf board yet. Reality…. it sucks.
Here I need to react: DCA is relevant not only from scientific point of view and there are clear case reports to support that. That is the best we can get: science + documented and reviewed case reports. Most of these indicates a potential added value for patients that have no other options.
That being said, as long as there are other options with potential, supported by better /more science and case reports, we should consider those first. That is clear. Discussion with oncologist is the first stepping stone we should always consider. Next to that we should consult organisations and/or medical doctors with experience in new options such as DCA.
However, after all this time, I can conclude one thing: when we deal with advanced cancer, we need to act. Based on my own statistics that is a better route than not acting. Even such simple drugs could add value https://www.cancertreatmentsresearch.com/drug-cocktail-that-could-double-the-average-survival-time/ However, I do not agree with acting blindly. We need to gather as much input as we can from multiple informed sources, BUT balance that with acting fast. Acting is key in advanced cancer.
Our dear Daniel.
I couldn’t agree with you more on what you said before.
So after all this time, talking, thinking, listening.
What do you see as the universal solution against this invader cell? IF any.
Something definitive as far?
Thank you for everything,
I cannot claim that I know an universal solution. But many of the treatments discussed on this website have been successful for some people when there was nothing else available anymore. However, I do believe we/humanity will find it soon. Until then, we can only do the best we can to fit as many pieces of the puzzle as we can to get treatments to a level good enough to extend and improve life as much as possible.
Hello, Alex.Thank you for your message. We have long hesitated to start DCA, although according to the in vitro results pretty good on my father by the test rgcc … But my father is no ok at the moment, so we decided to try. I prefer to try now rather than wait until it’s too late and regret not having tried. I hope you understand … We will of course try to do this with caution, that’s why I ask all these questions, we will start with a small dose and we will monitor the markers. Sorry for my bad english… Best regards!
They have to take into account that statins (atorvastatin) may be potential inhibitors for MCT transporters (MCT1 and SMCT) ref: https://bps.conference-services.net/resources/344/3339/pdf/BPSW2012_0097.pdf
Indeed, if I would go for DCA I would check on the web all the drugs I am using and see if there is anything known regarding their impact on the SMCT. As discussed in the post above, we want to avoid combining DCA with SMCT inhibitors and if possible combine DCA with SMCT upregulators.
Good night everyone,
It’s my first post so not sure if it’s a good idea to explain my medical history because I’m taking dca for relapsed Hodgkin lymphoma after several standard treatments and alternatives but without knowing all the information that I’m finding ultimately in this blog.
I’m 34 and fighting this since 8 years ago and since two years doing quite well with hoxsey protocol, diet, cannabis oil and standard suplements I have had a growth, high pcr, weight loss and itching so I went to the hematologist and the gave one round of cyclophosphamide plus steroids while a do a pet scan soon.
So I have started contacting coc in London and I have a Skype consultation next week, but I know the have a base protocol and I’ll know if I can add things as dca, ozone,..
And possibly I’ll take. Some bendustamine plus brexuntimab to try to reduce the current lymphoma grew.
So, specially Daniel where can I explain more details and ask for recommendations for a Hodgkin lymphoma? I’m opened to incorporate as many as approaches that could help, travel to German (I’m from Spain) and try to avoid allo transplant as they finally want to do me.
Thanks a lot for all the info and help that we can find in this great site.
I will respond asap on your post in the Forum https://www.cancertreatmentsresearch.com/community/lymphoma/please-help-with-new-strategy-refractory-hodgkin-lymphoma/#post-750
Below is my response to your post on the forum. I also add it here as it contains important info regarding the use of DCA in Hodgkin Lymphoma , but when responding it is best that you respond on the forum:
First, here is a summary on how the conventional approach to treat and the related options: Management of Relapsed and Refractory Hodgkin Lymphoma in 2018 https://jamanetwork.com/journals/jamaoncology/article-abstract/2687374
I will include the paper as attachment here, in case you do not have access to it.
I understand you already tried checkpoint inhibitors which are some of the last line, and u are now going to Cyclophosphamide or Bendamustine (Treanda) with Brentuximab (Adcetris). Both Cyclophosphamide and Bendamustine are alkylating agents, so they should work well with 2DG metronomic (2DG-M), in the sense that 2DG-M is expected to enable or increase the effectiveness of this type of conventional therapies.
Due to the relevance of CCR5 in hodgkin Lymphoma (Ref.) Maraviroc may help https://www.cancertreatmentsresearch.com/an-anti-hiv-drug-reactivates-the-immune-system-to-against-cancer/
Your report regarding the use of DCA and the swelling that occurs following that it’s essential in my view. I checked what is the metabolic profile of hodgkin Lymphoma and here is a very good article giving an important message https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.29934 The relevant message is found directly in the title: “Hodgkin and Reed–Sternberg cells of classical Hodgkin lymphoma are highly dependent on oxidative phosphorylation”.
Based on this, if I would be you I would immediately stop DCA and never touch that again. That is because Hodgkin lymphoma cells are highly dependent on a well-functioning mitochondria, and that is exactly what DCA helps. So in other words, there is a good chance for DCA to support Hodgkin lymphoma growth.
As the article above suggest, reducing mitochondria function in Hodgkin lymphoma cells may be the right treatment strategy. Here is a list of mitochondria inhibitors that could be accessible for most of the patients https://www.cancertreatmentsresearch.com/a-list-of-mitochondria-inhibitors/ Of this, Metformin is one of the most accessible, as well as Doxycicline. I would probably even add two mitochondria inhibitors at the same time as a part of a more comprehensive treatment protocol.
Therefore, in my view, combining the chemo that the oncologist is proposing with 2DG metronomic and with at least two mitochondria inhibitors, may be a good approach.
Using Tranilast and other NSAID medication (such as Aspirin) may help reduce fibroblast that are feeding tumor cells with lactic acid, for respiration.
Because hodgkin Lymphoma is relying so much on respiration, there is a good chance that MCT1 are very upregulated, which means that they may be highly sensitive to 3BP https://www.cancertreatmentsresearch.com/3-bromopyruvate/. However, when using 3BP there is a high chance of TLS that can be even lethal and it is specifically possible in blood cancers. Here I wrote a short post on managing TLS https://www.cancertreatmentsresearch.com/tls/ but the best way to address this to always increase the dose of treatments step by step whne we know that there is a risk of TLS.
I hope this helps and if you have questions please let me know.
I am here to help!
D, these mito drugs really have me interested.
We saw what happened with mito-3-BP, mito-DCA etc. VERY impressive results, though we still await the in vivo .
Love to see mito-E260, and mito -MG!
Wonder what would happen if they could put a pH sensor onboard, that could gain or lose a molecule in acidic/basic
environments! Would be very awesome if they add this level of specificity.
D, on page 45 of the pdf above, I found it interesting that Rh-123 was cleared within hours from normal cells while it took DAYS to clear from cancer cells. Hmmm. There would seem to be a fairly large window of opportunity to exploit there. You could dose up with Rh-123 (or some other drug with a differential clearance rate) and then go in with a second hit. Normal cells would have already cleared the first drug and so if you chose with care you would have room for therapeutic efficacy.
Thanks J. Nice paper and idea. Maybe you could contact the authors and ask what would be required for us (as a Foundation) to get access to such formulations?
D, it is stunning what could be done to help cancer patients with the current research.
For example, consider E260 combined with mito-DCA.
That could be a massively effective combo on paper.
First shut off glycolytic hyperdrive with mito-DCA and upregulate OXPHOS.
The above article noted that roughly 1 mg/kg of a mito drug is typically safe as it is the TPP that is where the focus on toxicity is on more so than the drug itself. The drug can concentrate up to 1000 fold in the cancer cell’s mitochondria!
I would love to see my idea of second generation mitos tried! If you make the mito drugs even more cancer selective by
adding in the pH sensor etc. the specificity and effectiveness of mitos would amplify. However, we are still waiting for mito-DCA and mito-3BP to go in vivo! It’s been 3 years! mito-DCA was shown to be astonishing effective against cancer cells!
I wonder what the law is with this? With mito-Q they did a phase 1 and perhaps a phase 2 and then they started selling it!
I am not sure how that is legal, though they must be using the argument that it is presumed GRAS. Well, might we also just presume mito-curcumin, mito-vitamin C, mito-vitamin E etc are also GRAS? This seems a fair hunch. The true “active ingredient” that can cause toxicity is the TPP. So, similar dosing range would seem reasonable for a range of other mitos.
Second, shut off OXPHOS! E260 gives you a very nice and clean hit on cancer cell’s OXPHOS!
This double combo could give you very powerful treatment effects.
You have shut off glycolysis overdrive and OXPHOS!
Another push on glycolysis with vitamin C or fasting etc. would likely have very large effects.
The E260 didn’t try this, though I would then love to see metronomic E260 dosing.
The dosing window for E260 in the original research was only about 90 minutes!
Then detach HKII from VDAC …
Then try some X-Ray PDT.
D, such powerful cancer medicines out there. I wish that cancer patients will be given an opportunity to benefit from them.
Alex, I offer my deepest condolences.
I am so impressed with the overwhelming efforts that those on the thread have gone to to help their loved ones. The enormous act of love and devotion that you have shown is the fuel that drives us to find something that will help others that walk on your pathr.
Best Wishes, Jcancom
Ai facut tot ce a fost posibil.Mama ta este mandra de eroul ei si, de dragul ei, ai grija de tine si ramai acelasi.
multumesc din suflet pentru cuvintele bune dar si reale.
Your pain is my pain please accept my condolences on your dear mother,so now it rests the spirit of a warrior ,
Are big and brave don’t forget
Thank you very much Marcos for your loving words and thoughts.
She was a great warrior, i feel i am too as her son, but i have big doubts when i remember all the incredible extreme times my mom managed to stay alive and continue to want to live to the very last second, sometimes i complain about lack of food or rest, while she had way way way way more problems all at once and yet continued to push on.
Thank you for being with me,
I wish i would have had more time for all this here, but things were impossible, and i am a PC user, not a smartphone guy.
Re: Cancer that relies on mitochondrial respiration
I am trying to understand mitochondrial respiration. I understand that Hodgkins Lymphoma relies on mitochondrial respiration, so DCA is contraindicated. Is this true for all cancers once stage IV, that then stage IV cancers also rely in mitochondrial respiration? Jane McLelland writes “Dichloroacetate (DCA), a pyruvate dehydrogenase kinase (PDK) inhibitor enhances the oxidative activity of cells by activating pyruvate dehydrogenase (PDH), the enzyme of glucose oxidation in mitochondria. At high doses it causes neuropathy and inflammation. Because it fosters the conversion of pyruvate into acetyl-CoA and activates mitochondrial OXPHOS, it may be best avoided, especially in advanced cancers that use mitochondrial respiration.” Mclelland, Jane. How to Starve Cancer …without starving yourself: The Discovery of a Metabolic Cocktail That Could Transform the Lives of Millions . Conscious Dreams Publishing. Kindle Edition.
This is an important and a little more difficult subject at the same time. There are different views on mitochondria: to switch off or to activate? There are good reasons for both, depending on the situation and choices we take as discussed below. I think Jane’s view presented in her book is a relevant one but her statement is at a too high abstraction level. I think in order to have a relevant discussion on this subject we need to go one level deeper. Before zooming in, I would say that cancers in advanced phase rely more on glycolsis compared to mitochondria. On this line we could argue the opposite, i.e. in advanced stage, we would prefer to have cancer relying more on mitochondria (with the help of DCA) in order to slow down growth (compared to the highly glycolitic cancers).
In order to understand when to use and when not to use DCA, we need to think what is the strategy that we want to use to fight cancer:
– If we want to focus on the ATP depletion and as a result “energy starvation”, I would not use DCA, and I would focus on combination of ferementation and mitochondria inhibitors as discussed here https://www.cancertreatmentsresearch.com/shutting-down-the-power-house-of-cancer/
– If I would want to focus on ROS generation, as a way to fight cancer, I may actually go for DCA together with other ROS generators and anti-oxidant inhibitors. This would be a good combo with chemo and radio-therapy. (However, I would probably not combine DCA with radio as for that it makes more sense to use mitochondria inhibitors, in order to have less oxygen consumed by respiration and more available for radio-therapy pro-oxidant action.)
– If I would go for immuno-therapy I may also consider using DCA prior to that since it may reduce fermentation which could in turn let the immune cells do their job since less protons will be exported into the tumor micro-environment.
As mentioned above, I do know personally two people (advanced stage) who strongly benefited from DCA alone – that will always keep a positive bias in my mind when it comes to DCA. Next to that, there are also positive results published from Medicore on advanced cancers. So I think this is a great tool, that may be effective in some cases and is cheap enough so that it can be accessible to many. I agree DCA has to be used with care to avoid neurophaty (which in any case is reversible once DCA is stop). I also agree, that in order to avoid possible inflammation, in advanced cancers I would move up towards the target dose step by step.
Excellent. Thank you, Daniel.
About neuropathic pain. CBD is ordinarily very effective at treating this type of pain. Perhaps people using DCA can also use CBD?
I have metastatic prostate cancer and the CBD has proven to be good at keeping my PSA down. I don’t imagine that there would be a conflict between DCA and CBD? Do you know if there is?
I have ordered DCA and I’m waiting for it to arrive – looking forward to achieving NED.
Thanks and regards!
Fantastic article. Thank you so much. I am going to add DCA to my protocol for stage 3 her2+ HR- BC. I ordered my product from a company in Lithania called DCA Lab. I wonder if you happen to know if this is a reputable source? I do not have a doctor who will prescribe off label drugs. I am in France.
Thank you again.
You are very welcome! This (DCALab) is probably the best quality I am aware of.
Wow! Thank you for such a prompt response and, of course, I am thrilled you know and recommend this source. This is a huge relief for me.
You are very welcome Tina!
I am formulating my DCA protocol and I wonder if you might answer a couple of questions that were raised by your article. I plan on pulsing every other week as per your suggestion. I will be taking with Metformin and Fenbendazole and will discontinue Quercetin. Should I also discontinue MSM and iodine supplement? Also, should I take the quercetin during the off week of DCA? And, finally, I am unclear as to whether it is beneficial or not to include ALA and Garcinia Cambogia and, if so, at what doses and should they be taken all the time or just during off week? Are there any other metabolic blockers I should avoid or add during this protocol which I plan to do for 4 months?
Thank you so much for your help.
I have no info that would suggest not to use MSM and iodine. Quercetin is debatable in breast cancer. Some breast cancer patients are using it next to other drugs and supplements, and they are successful but there is some research indicating it may exert both agonistic and antagonistic activities on estrogen receptors. ALAcould make sense, Garcinia (HCA) always makes sense in my view when it comes to hormonal cancers https://www.cancertreatmentsresearch.com/reduce-cholesterol-in-cancer-cells-to-fight-cancer/ HCA and ALA dose were discussed here https://www.cancertreatmentsresearch.com/another-weak-spot-of-many-cancer-cells-atp-citrate-lyase-inhibition/ If chemo is used, I would not use ALA. I am not sure which strategy you want to follow, depending on that and the conventional treatments currently used, there are various other drugs and supplements that could make sense.
Here are some strategies I shared so far:
Caution for use of DCA in neuroblastoma:
DCA promotes progression of neuroblastoma tumors in nude mice
Hi Daniel –
Thanks for the excellent article. You mention that procaine can be taken as a DNA demethylating agent. Could you tell me how much is commonly taken and in what form?
Thank you. I used to use this one in the past in an inject-able form but I have to see if I find the dose. In any-case Gerovital, a Romanian treatment used for decades as an anti-ageing treatment contains procaine. IN order to have a feeling on the safe dose you could use as a reference the daily dose suggested by Gerovital (which I think is on the high side) https://www.pcfarm.ro/prospect.php?id=1445 you can read this with Google translator.
2-Deoxy-D-glucose Enhances Dichloroacetate Antitumor Action Against Lewis Lung Carcinoma
Results: DCA administered as a single agent did not affect primary tumor growth but decreased the number and volume of lung metastases by 60% (p < 0.05) and 90% (p < 0.05), respectively. In mice treated with 2DG only, primary tumor volume as well as the number and volume of lung metastases were not affected. Combination treatment with DCA and 2DG resulted in the decrease of primary tumor volume, the number and volumes of lung metastases by 70; 46, and 90%, respectively (p < 0.05). High antitumor activity of DCA + 2DG was associated with 31% decrease (p < 0.05) of lactate content in tumor tissue and 120% increase (p < 0.01) of ROS production in CD14(+) cells recruited to the region of tumor growth.
Could this combo work better than DCA alone with metronomic chemotherapy?
Hello Daniel, I hope this finds you well. You advised me some time back on adding DCA to my metabolic protocol as a kill phase. I am back on for the last 2 weeks after taking a bread due to neurpathy in feet. This time I I started the DCA two weeks into a 40 day vegetable juice fast. I had intended to do the 2 weeks on 1 off regimen. I just finished first 2 weeks back on. The last 7 days of my fast will be water only. I am wondering if there would be any benefit to continuing the DCA for one more week and begin the 2 on 1 off when the fast is over. Do you have any thoughts on this subject? BTW I am treating stage 3 her+ BC.
Thank you in advance.
Nice to hear from you again. “kill phase” doesn’t sound like my wording – it sounds like Jane McLelland, so you may have got this suggestion from Jane ?
However, to answer your question, a typical schedule for DCA is indeed 2wk ON and 1wk OFF https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5554882/ in thsi article they also discuss various ways to address neurpathy including R-lipoic acid. The authors of this article are the World experts in applying DCA on cancer patients.
Hello Daniel – Hope you are well. I am in the middle of 3 month kill phase using DCA. I am experiencing considerable neuropathy in my feet. I am taking B complex with added thiamine and B12 plus ala and doing exercises but no change. If I push through and finish the last month and a half, am I pushing the limit with neuropathy? It started with my toes but a couple of days ago moved up to 3/4 of both feet. Also, is there a problem with phasing into high dose melatonin while on DCA to your knowledge?
Please take care with DCA. Normally the neuropathy induced by DCA is reversible, but if you keep that on long term, I am not sure. Please contact Medicore clinic in Canada – they have good experience with long term use of DCA.
I just checked the literature to answer your other question: based on the majority of the literature I came across, Melatonin and DCA should work well together as Melatonin is also inhibiting glycolisis and acting in a similar way as DCA from metabolism point of view.
We’ve learnt a lot from the site, thanks for putting all this together!
My mom has pancreatic cancer stage 4 with mets to her liver, we started DCA along with Fenben one month after her diagnosis. Her Ca199 was at 65000 when in August when first diagnosed. It came down to 55000 before her 1st chemo (we were jucing that month and taking EGCE and curcumin) then her CA199 came down to 45000 one week after chemo, the interesting thing is that it came down to around 20000 (somewhere between 20000-30000 as we changed hospital the lab did not give us an exact figure) right before her second and have stayed there for the past 6 weeks. She just finished 4th treatment of folfirinox but due to severe neuropathy she does not want to take folfirinox anymore. We added repurposed drugs, IVC and a list of natural supplements e.g. curcumin, quercetin, green tea extract, melatonin, milk thistle, selenium, etc. along the way. I am not sure why her CA199 dropped so much at the beginning and this makes me wonder if we have taking the wrong supplements, after reading this article again we have removed quercetin while on DCA, I just wanted to see if there is anything else that will work against or make DCA less effective? Is curcumin, EGCG, fish oil etc. okay to take? Many thanks!
Is your mom still considering taking chemo (maybe lower dose)? Is she still on chemo, or she is now refusing completely?
If you answer these questions, and put everything you are using in an Excel file with doses and how they are implemented in time, you can e-mail me and I will give you my feedback. (I know people who succeeded to push a lot more the markers down while supporting folfirinox with repurposed drugs and supplements.)
I am interested in your feedback regarding the timing of complementary treatments. My mum started on a combination Tepotinib (MET inhibitor) and Osimertinib (EGFR inhibitor) over a month ago, and recent CT scans have shown significant tumour shrinkage with this new therapy.
I have also recently purchased DCA but haven’t started on this. My question is – given the effectiveness of Tepotinib/Osimertinib combo right now after only a month exposure, what is the best option for treatment sequencing? Should I:
1) Introduce other strong treatments in parallel such as DCA (or 3BP/2DG) to try and boost the killing of cancer cells right now, at their weakest point
2) Wait until the response stabilises and no further evidence of shrinkage is seen before adding other strong treatment, to prolong PFS
3) Wait until evidence of progression before introducing other treatment, in order to prolong OS
Thanks for your feedback in advance 🙂
Coincidentally, I came across this interesting article today talking about the importance of timing when deciding to add a second therapy on top of the first one:
Hi Jun, thank you. The proposed strategy is interesting and relevant indeed. It makes very much sense.
I understand that the article refers to a mathematic model that is very simplified and not actually tested in vitro or in vivo. The argument is quite compelling, however. Does it change your opinion now that you’ve reviewed the article, or would you still suggest to maintain the current treatment and introduce new treatment like DCA only when effectiveness decreases? To be specific, when you say decrease in effectiveness, do you mean “stable disease” or “progression”?
Jun, you have offered an interesting perspective. The last mile problem is of critical importance in cancer: It is not so much removing 99% of the cancer cells that is the most difficult but that last 1%. We have seen with others for example Jess (below) that dual treatment can create very large short term cancer responses, though as your article notes, this might not be the best strategy. Adding in the second treatment somewhere in the middle (i.e., not at the start and not after NED) does make good intuitive sense. Treating at the start with dual treatment will simply select for the resistant strain and allow new monoclonal tumors to develop without disruption. Treating in the “middle” would stress polyclonal tumors that had not been selected. One could imagine that under such circumstances much of the tumor mass could be vulnerable to the treatment and the tumor would be collapsing all around any resistant cells. In such an environment, the basic community of cells needed to maintain a functional tumor might no longer be present.
It is unclear exactly at what point the dual treatment would be optimally applied, though further research could clarify this question. One consideration that might be helpful is that once NED were reached than perhaps a liquid cancer biopsy could be taken and the cells analyzed. Such an analysis (genetic) might reveal a treatment that could be applied to achieve a permanent response. Knowing exactly the vulnerabilities of the resistant cells might avoid the problem of
watching in frustration as these remaining cells entered into an exponential growth phase. Thinking more in terms of cancer cells than the tumor bulk could also be useful. For example, perhaps the antibiotic + vitamin C protocol might be a treatment worth trying.
Best Wishes, J
Thanks a lot for your detailed response! It is indeed certainly a challenge to figure out the best time for incorporating treatments, especially if the current one is working well so far. There is always the concern about disrupting something that is currently working effectively, on the other hand, it is also almost inevitable that resistance to the TKI treatment will eventuate in the medium term.
The lung cancer that we are trying to tackle is quite an aggressive form (e.g. liver mets grow to 10cm+ within a month), which is what we observed previously after a year on osimertinib monotherapy with a few complementary treatments such as Vitamin C infusions. I’m a bit scared that certain therapies may induce similar exponential growth again.
That being said, DCA seems to be reasonably safe to use in conjunction with TKIs. I am thinking of adding this once we receive confirmation of stability or NED. Perhaps monitor blood tumour markers, and introduce more intense treatment such as 3BP/2DG and Wnt inhibitors if tumour markers start to trend upwards.
Your comment about taking a liquid biopsy at the point of stabilisation makes a lot of sense! I will explore that avenue.
I’ve seen your questions, but I did not have the chance to respond earlier. I apologize for the delay of my response and thank you to J bur adding his valuable comments.
This is a challenging question, with a bit more abstract answer:
I think the discussion here is about core treatments, treatments that we think are “sharp” enough to affect one population of cancer cells (effectively and alone). I could see DCA in that category, but it would have to be supported by a inhibitor of glycolisis that inhibits glycolisis towards the end of the pathway, such as Diclofenac. From the “new cancer treatment” basket, another treatment that I would see here as a good example would be Salinomycin.
I see DCA more as a horizontal treatment, that if it works can affect most population types, while Salinomycin as a vertical treatment that is more likely to work but on a specific population types only. Along this perspective, the question for DCA-like treatments is how to increase the chance of their effectiveness, while for Salinomycin-like treatments is how to increase their relevance for other cancer cell types (different cancers and/or populations type).
I see the treatment that your mom is doing now a more Salinomycin-like treatment, and if I would look at adding other treatments as the paper you shared suggests, I would add along this line.
On the other hand, DCA-like treatment (or a metabolic strategy) seems to fit more as an option if what is being done now slows down in effectiveness. Maybe this way of thinking is also a bit biased by the fact that I think, when things go well, we should continue doing that and not change too much.
I hope this helps a bit.
Thank you for your comments, and please don’t apologise – I am already very appreciative of your time, and fully understand if you don’t have the opportunity to reply 🙂
Just to clarify, are you suggesting that because my mum’s current treatment is more targeted towards specific mutation/cancer (“vertical treatment”), we should focus on enhancing that particular mechanism? The use of TKIs inevitably result in new mutations developing that are resistant to treatment, however the range of possible new mutations can be varied so it is impossible to block all, so it can be quite difficult.
Jun, I have not been able to click on your name to trace back on your mom’s history, though I assume you are coping with lung cancer. Lung cancer is actually one of the more responsive tumor types to metabolic interventions (not entirely sure why this is true). The chemotherapy clinic has had notable success with it.
D has done a post on Hydrogen therapy; it also seems to be especially effective in lung cancer. Perhaps metronomic hydrogen treatment as an additional treatment after chemo could be considered, though as D has noted the antioxidant effect would need to be treated away from other pro-oxidant. Hydrogen therapy seems especially impressive because it can be applied over extended periods and it has direct access to the lungs. Having a number of fall back treatments after achieving NED would be wise as we have seen that once chemo is no longer effective tumor markers can skyrocket.
The highly skilled are able to treat purely with metabolic treatment. Such an approach could fit extremely well into the ideas suggested in your article. Imagine being able to bring down the tumor mass in round 1 with metabolics and then “in the middle” add in targetted treatment! This would seem almost ideal; it would mean that you could retain your ace card while removing the bulk of the tumor mass. A complex metabolic therapy would also have a chance of continuing to offer benefit.
Best Wishes, J
Yes, the cancer we are dealing with is NSCLC (EGFR and MET mutations). Currently we are also using metronomic hydrogen therapy, not only as a treatment against cancer but also to mitigate against severe toxicity such as pneumonitis. So far so good 🙂
As H2 gas therapy is antioxidant, it poses a bit of a dilemma when I am looking to add other promising treatment options on top of it such as DCA, 2DG, 3BP, as they all seem to work on the pro-oxidant mechanism. If I were to introduce one of these treatments, I would have to pause H2 gas.
We will currently stay on current treatment and review blood markers periodically, and as Daniel suggests, change up the strategy once the effectiveness is shown to be diminishing.
Might I ask how you are able to get 3BP treatment? We are based in Norway with quite limited treating options when it comes to unconventional cancer treatments. Stage 4 NSCLC, also doing 6 hrs/night hydrogen inhalation, together with a newly introduced TKI (lorlatinib) after the cancer progressed on crizotinib after less than a year.
Sorry for the late reply, only just saw this now. To be honest, I haven’t looked too deeply into where I can source 3BP, although Daniel has written a few articles on the topic – perhaps you can reach out to him first if you can’t find a source listed on the website. I believe another contributor on this site (Manuel) has been using this, and he also resides in Europe.
I was simply posing hypotheticals at this stage, haven’t managed to get my hands on any yet 🙂
Great to hear that your dear mom sees positive results with the combo. Since the tumour shrinkage is significant, I would not interfere with that now. I would consider increasing the effectiveness with other drugs only if there is a reduction in effectiveness of the Tepotinib/Osimertinib combo.
Have you encountered any cases of patients who had experienced cancer progression/acceleration upon adding DCA to existing treatment, where otherwise they were more or less stable? If so, would you agree that the mechanism is likely to be increased ATP synthesis (OXPHOS), and would you suggest adding some specific drugs/supplements to counteract this?
The context is that my mum is still doing reasonably well with Osimertinib/Tepotinib combo (plus H2 gas inhalation), but tumour markers are starting to creep up on the most recent blood test. I’m thinking of taking her off H2 gas and introducing DCA, given the latest PET scan shows the pre-existing liver lesion still lighting up. Just nervous about whether making this change may possibly end up accelerating growth instead…
Alex (mom with lung cancer), on this website, has reported a potential faster progression after adding DCA, but latter he said (as I remember) that maybe it was not DCA but just cancer progressing (since it was also progressing before) and maybe he should not have stopped that. Another friend added DCA for his wife with breasts cancer, and he was progressing during that time. However, not clear of DCA had anything to do with it.
On the other hand, a friend with lung cancer adding DCA, and Diclofenac at the same time, both high dose, was totally cured of lung cancer. He did not do any chemo or other treatments (except some Artemisinin and hyperthermia), so this was a clean result. My wife used DCA for long time and we did not experienced any progression due to that, while overall her life was extended with years (not sure if DCA added value but we did use it both as capsules and intravenous). Another friend on his Blog, used DCA for his mom with breast cancer and once he started adding DCA prior to taxol, she started responding again to chemo.
No matter what treatment I would use, I would keep an eye on the development and adapt treatments accordingly. If you feel this is the right tool, I would use it. If doubts, better not. There are enough treatment options with potential.
Thank you for your feedback Daniel 🙂
I read about your friend using high-dose diclofenac + DCA and having good results.
My father is in a similar situation. Due to pain, he is using diclofenac injections, 2x 75mg total per day (maximum allowed per prescription). I started him today on DCA at a low dose 250mg, with the thought of increasing it over the next days to a maximum of 1000mg (15mg/kg body weight).
He will start radiotherapy next week on a bone lesion so we will have 1 week on DCA building dosage, 1 week off (radio), then start again at the high dose.
I hope this will help him with eating ok again and clear the sensation of fullness which I suspect is due to lactic acid produced by the tumor.
Considering he started immunotherapy with Keytruda about 2 weeks ago, and you mentioned that DCA increases Tregs … is there something else than Cimetidine that can inhibit Tregs? Cimetidine is not available in Europe it seems.
Also, is there something else to be used for neuropathy? He also has neuropathy in hands and feet because of chemo and radio and I am afraid DCA will amplify it.
Cimetidine is available on eBay as Tagamet. It’s and over the counter drug in US.
Indeed, as Johan mentioned below, Lipoic Acid is known to be good against neuropathy. He may need some intravenous Lipoic Acid. If you are located in Bucharest, you will find clinics there giving Lipoic Acid intravenously, but it should be taken 7 days away from radio.
Thank you Daniel!
I found Tagamet on ebay.
What dosage should be used? 200mg per day? Or is it calculated by body weight?
Is cimetidine enough for inhibition of Tregs? He is on Keytruda right now and I don’t want to make matter worse by inhibiting his immune response using DCA.
Great to hear that you found it!
Nobody knows what is enough, but based on science we do know that Cimetidine is doing a good job in that direction, as well as in inhibiting metastasis. That is also my experience with it – it was an important contributor in keeping an aggressive cancer my wife had, from metastasis for years.
The only point with Cimetidine is that is inhibiting (temorarely) a liver enzyme relevant for metabolizing drugs – so you need to check the interaction if your dad is on other drugs.
Typically, when its about an active cancer, cancer clinics in Germany are using 400mg 2x/day. If its preventive, its 200mg 2x/day.
I hope this helps.
Curcumin + Lipoic acid may help with neuropathy.
I had an excellent response during the first month using DCA but then it became ineffective. Nothing else has changed on my drug regime. Then, I stopped DCA for one year and decided to try again as my diseases was becoming more aggressive. This was June this year. Once I again I experienced the same, the first 3-4 weeks on DCA were incredible but afterwards it stopped having any effect and the diseases started to spread again.
Do you know of other similar experiences? Is there any way to overcome that? This year I am also on Omeprazol, metformin and both times I took it with B1 and ALA.
I was thinking maybe it develops some kind of resistance as you describe in your article. Do you think intravenous DCA would help? Did your wife take it once a week or daily as well?
I would appreciate any help on this. Many thanks.
Daniel, once again, awesome article! You just pointed me to an answer to something that has been bugging me for like 2 years. Why when I take DCA on a ketogenic diet do my ketone levels get ridiculously high (up to 8mmol)? I’ve found almost no research on it but the paper you shared about it inhibiting gluconeogenesis makes quite a lot of sense. If glucose is suppressed, then ketones should rise.
Thank you for the kind words and sharing this finding!
Nice match of the literature and your experience.
Here is one post addressing in a more specific way gluconeogenesis https://www.cancertreatmentsresearch.com/addressing-gluconeogenesis/
It appears CoQ10 activates mitochondrial function.
Could CoQ10 be taken alongside DCA.
Or should CoQ10 be taken alongside ALA & HCA.
Do you know of any negative aspects of taking CoQ10 for cancer, especially colon cancer.
PS, keep up the great research and articles and the top supplements which I have been purchasing for a while now.
Thanks and best regards,
Thank you for your question and kind words. If we think only about the supplements and drugs you mentioned, I see them all working well together since ALA, DCA, CoQ10 will help mito function, while HCA works in the downstream.
If other pro-oxidant treatments are used at the same time such as radio, chemo, I woudl not use CoQ10 and ALA due to their super anti-oxidant activity.
Hi, I’d like to ask about thiamine as I have been warned not to take B vitamins, and I had cause to look up thiamine specifically recently and it was definitely a no…. Although “high dose” apparently would be a good idea, abs I can’t remember if I ever saw what high oral dose was (I was looking for something a little different that would have been injected). Today I took a little methylated Bs (opened a high capsule) as I have started DCA and already felt depleted from metformin and diet, but for ordering a thiamine product specifically what should I be looking for in dosage or anything else? I am already extra tingly in fingers and feet.
Thanks for any thoughts.
Hi Daniel, my partner (Stage IV BC ER/PR+) followed a protocol based on Jane McClelland’s which involved taking Metformin, Leterazole, Propanol, Phenylbutyrate and cocktail of other supplements. Since this protocol did not appear to keep the cancer markers in check, she started on DCA+B1+ALA plus Metformin, Leterazole (1/2 dose) and other supplements such as Boswellia, Tumeric etc.
However, it appears since she started on DCA her energy levels have dropped to rock bottom level and she appears to loose weight as well plus lost apetite. We were under the impression that Metformin and Leterazole should provide some synergy to the DCA protocol but could Metformin + DCA blocking glucose more than necessary? Is it better to stop Metformin, Leterazole combo for the time being?
Thank you for your question, and I am sorry it took longer to respond. J kindly informed me about the question.
While I woudl expect Metformin could lead to such an outcome, I do not see how DCA can influence that. Indeed, I woudl stop Meformin for a while but not Leterazole for now. The flu, you mentioned below, can also trigger inflammation and progression, so I woudl try to address that as well with supplements and/or drugs.
Hi Daniel, thanks for the response. We have stopped Metformin but continuing with Leterazole. She has no flu symptoms now but very very low in energy and is breathless most of the time. A recent CT revealed many tumours close to the diapraghm and the doctors are of the opinion that this could be the cause of breathlessness. Her O2 saturation is good but the pulse rate is 90 – 100 bpm range. Currently, she is on DCA, Leterazole, Ivermectin, Vit A, Zinc, Boswellia, Danshen, Curcumin, Paw Paw. We have stopped Benfotiamine after reading Johan’s post below.
Would like to know whether you have any further comments/suggestions.
Hi, sorry to hear of your wife’s situation. In a Phase II randomized study of neoadjuvant metformin plus letrozole versus placebo plus letrozole for ER-positive postmenopausal breast cancer Grade 3 side effects were reported in three patients (vomiting, high blood pressure, weight loss). Metformin can cause an increase in lactic acid which might be related to the fatigue your partner is feeling.
Hi Johan, thanks for the info on that study. My wife did seemed OK with the Letrozole Metformin combination until she came down with flu a few weeks ago. The flu did take a lot out of her, energy wise. There was also a noticeable drop in her weight with Metformin. With the intention of isolating potential causes, she stopped taking Metformin two days ago – so hopefully within a week or so we will see some improvent in her condition. She is continuing with DCA+B1+ALA plus a few supplements.
Hi, I know that B1 is used as part of protocols such as with DCA, however, it’s important to know that B1 is a tricky substance to use for anticancer purposes.
Alterations of vitamin B1 homeostasis following oxidative stress in breast cancer and impact of supplementation on cellular redox homeostasis
Life is never meant to be easy!!! If the contents of this article is correct (not doubting that it is not) then I presume taking B1 off the list makes sense at least in the case of BC?
Also, given the reason for taking B1 is purely to mitigate the potential neuropathy effects, I guess stop taking B1 unless symptoms of neuropathy manifests may be a better alternative?
for more information on niacin, I recommend listening to this audio book:
Life is never meant to be easy!!! If the contents of this article is correct (not doubting that it is not) then I presume taking B1 off the list makes sense at least in the case of BC?
Also, given the reason for taking B1 is purely to mitigate the potential neuropathy effects, I guess stop taking B1 unless symptoms of neuropathy manifests may be a better alternative?
Alpha lipoic acid in combination with curcumin can help protect against neuropathy, and maybe try magnesium with B6 instead of B1.
My wife is taking ALA plus Curcumin already. Will try B6+Mg as an alternative to B1.
Sounds good, hope she feels better soon.
Hi johan, I did a bit of research on Benfotiamine and breast cancer and it appears the jury is still out on this. Interestingly, some find that at low doses of B1 the proliferation of cancer cells is more and that at high doses it slows the proliferation. Almost half the papers I looked at are showing negative outcomes while some are showing positive outcomes. Given the uncertainity, perhaps it may be best to take the approach suggested by you earlier – ie B6+Mg.
Unfortunately, in my wife’s case, the tumour markers are still rising unchallenged although she has been on DCA for almost a month now. She is terribly weak and has many aches and pains.
Hi, in my view, when you have a clear indication of cancer progression as is in the case of your wife´s cancer, it means that the treatment is not working. You posted that she is on DCA, Letrozole, Ivermectin, Vit A, Zinc, Boswellia, Danshen, Curcumin, and Paw Paw. What conventional treatment is being offered by her oncologist?
Another forum member’s wife was on a similar protocol, with DCA, benfotiamine (b1) metformin for TNBC and it did not help. Here’s the forum thread: https://www.cancertreatmentsresearch.com/community/breast-cancer/tnbc-testing-strategies-in-a-ned-situation/paged/14/#post-6845
I would consider niacin, it could address the fatigue and aches. Start with a low dose to avoid the discomfort of the flush, and with a meal in the evening. Start with 100mg or even 50mg. If she’s fine with the dose in the evening, start giving her that dose with every meal and gradually up titrate. The flush effect will subside with continuous usage of the niacin. You can buy niacin on bulksupplements dot com in powder and you’ll need a digital scale to measure the amount initially, for the lower dose (50mg).
btw, the flush effect is not dangerous but can be a bit uncomfortable. To reduce the flush it’s important to always take it with a meal and to start with a low dose as explained above. Taking some vitamin C or butyrate before can also help reduce the flush.
for more information on niacin, I recommend listening to this audio book:
Oral application of magnesium-L-threonate enhances analgesia and reduces the dosage of opioids needed in advanced cancer patients—A randomized, double-blind, placebo-controlled trial
The effects of B vitamins on pain relief and improving physical function in patients with medial compartment knee osteoarthritis (in particular B2, B3 and B6 in combination with celecoxib)
celecoxib + luteolin synergy in breast cancer
in addition, curcumin seems to be a good option in combination with celecoxib:
Curcumin-Celecoxib: a synergistic and rationale combination chemotherapy for breast cancer
Dichloroacetate as a novel pharmaceutical treatment for cancer-related fatigue in melanoma
With regards to your question “What conventional treatment is being offered by her oncologist?” the answer is none – they have nothing to offer but palliative care. Just came back from the hospital after consulting the oncologist and her plan is to keep my wife as comfortable as possible till passes away. While I am not in denial, I would like to give everything a go as long as I can afford it. I will check out your links on niacin but I presume it is not a cure or something that can put her on remission?
Hi, I am very sorry to hear this. It is unlikely niacin or any other single substance can cure cancer at this very late stage. In his book, Hoffer has a chapter on the use of niacin in cancer treatment. You could try the no-flush niacin, 500mg twice or three times a day, and see if this alleviates her fatigue or pain. In addition, although not a first-line pain therapeutic, cyproheptadine may offer relief of symptoms. Magnesium has a calming effect. Celecoxib alleviates pain. Beta-Caryophyllene (East Coast Sour Diesel). B6. Boswellia. Palmitoylethanolamide (PEA). Acetazolamide.
Cyproheptadine may significantly improve survival outcomes of sorafenib-treated advanced hepatocellular carcinoma patients.
The median overall survival was 11.0 months (95% confidence interval: 6.8–15.1 months) in the combination group compared with 4.8 months (95% confidence interval: 3.1–6.6 months) in the control group (crude hazard ratio = 0.45, 95% confidence interval: 0.22–0.82).
Case report cyproheptadine: This is the first report to investigate a successful clinical approach in cyproheptadine monotherapy for an advanced HCC patient with bone metastasis.
Case report bicarbonate: “GL is a 79 year old man followed in the GU clinic at the Moffitt Cancer Center. He presented with hematuria in January 2004 and was found to have a large right renal cancer with clot extending into the inferior vena cava (stage T3b, N2, Mx). He underwent a nephrectomy with clot removal at the Moffitt Cancer Center in February, 2004. In June, 2005, he developed metastatic disease in his liver. He was treated with Sutent, but the tumor progressed with metastases developing in the subcutaneous tissues and retroperitoneal lymph nodes. He was unable to tolerate ALT-801. In September 2007 he elected to discontinue all conventional therapy and began a self-administered regimen of vitamins, supplements, and 3 “heaping tablespoons” of sodium bicarbonate in water per day (about 40 grams total). As of the date of this submission, he has maintained this therapy with no complications. His weight is stable. He walks 2 miles every day and had cataract surgery in March 2008 without complications. CT scans from Dec 5, 2007 and April 18, 2008 are shown in figure S3. These images are representative in that some of the liver lesions have increased in size, some have decreased, and some have remained stable. Interestingly, the tumors that were necrotic in the initial scan became much less so on the follow-up study. At the time of this submission (2009) the patient remains clinically well. ” https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3718046 (see supplementary data)