Dichloroacetate (DCA): Effective, Cheap & Accessible Drug to Fight Cancer

Background:

First, I will start this post by wishing all the readers a Happy New Year full of health for you and your family, and a lot of success in everything you do! I also like to specifically thank to Ann who was the first visitor/friend this year to post a wish to all of us on this website.

Dichloroacetate (DCA), is probably one of the first anti cancer drugs I came across when starting to search for new effective drugs that can help fight cancer. After all these years, I believe even more in the potential behind DCA. This is because, I do know personally two people/friends who benefited from DCA treatment and are alive today due to DCA. And they used no other major treatments such as chemo. One of them is a man diagnosed >10 years ago with stage IV colon cancer and the other is a man diagnosed >5 years ago with stage IV lung cancer. And both of them are alive today.

It is true, after about >5 years their cancer came back and they succeeded to manage that with various elements including 3BP. Below I also intend to shortly discuss the mechanism through which some cancers responding may become resistant to DCA and possible routes to overcome that.

DCA has been extensively discussed, investigated and used in both alternative cancer treatment and academic world. With this post, I do not intend to consolidate all the extensive research on DCA. Instead, I will make a short summary with the most relevant points I am aware of and that need to be considered when DCA is used as an anti cancer treatment. Next to this post, a lot of relevant discussions on the use of DCA can be found at the following website: http://www.thedcasite.com

DCA is a white powder, the salt version of Dichloroacetic acid. Outside the oncology field, DCA is a drug known for many decades that has been considered for treatment of lactic acidosis. (Ref.1, Ref.2) DCA as an anti-diabetic and lipid-lowering drug (Ref), with potential for treating these conditions as well as myocardial and cerebrovascular ischemia (Ref.).

While known for long time, the potential of DCA in oncology has only recently begun to receive attention after major publications from the University of Alberta, Edmonton, Canada where the scientists were concluding the following: “Here, we review the scientific and clinical rationale supporting the rapid translation of this promising metabolic modulator in early-phase cancer clinical trials.” (Ref.1, Ref.2), scientific publications that until today are cited by >100 other scientific publications. An explosion of press coverage followed that: https://www.youtube.com/watch?v=oq-oT8-2tC8https://www.youtube.com/watch?v=8nTg53izwpEhttps://www.youtube.com/watch?v=oq-oT8-2tC8; and so on …

Due to its mechanism of action DCA may be relevant to most types of cancers, including:

  • breast cancer (Ref.1, Ref.2, Ref.3)
  • colon and colorectal cancer (Ref.1, Ref.2)
  • prostate cancer (Ref.)
  • acute myeloid leukemia (Ref.)
  • oral squamous cell carcinoma (Ref.)
  • glioblastoma (Ref.)
  • Ovarian cancer (Ref.)
  • Neuroblastoma (Ref.)
  • Lung cancer (Ref.)
  • Non-Hodgkin’s Follicular Lymphoma (Ref.)
  • and most of the other cancers …

Other positive effects:

  • reduces pain in cancer (due to acidity lowering effects) (Ref.)
  • reduced massive ascites in 50% of the patients without adjuvant chemotherapy (Ref.)

That next to the fact that is a low cost, low side effects and accessible to all people, makes DCA one of the drugs that can be tried by all cancer patients.

Even more, due to its mechanism of action, DCA supports chemotheraphy and radiotheraphy (increases Reactive Oxygen Species in cancer cells and reduces acidity around the tumors) (Ref.1, Ref.2). And even more, because the acidity around the tumor is reduced, the immune system can increase its activity in those specific areas.

But as you will see if you read the rest of this post, there are some more tricks that we need to use in order to increase the chance of DCA for effectiveness against cancer.

Anecdotal stories:

See http://www.thedcasite.com/

Case reports in humans:

Long-term stabilization of stage 4 colon cancer using sodium dichloroacetate therapyhttps://www.ncbi.nlm.nih.gov/pubmed/27803917

A case is presented in which oral DCA therapy resulted in tumour stabilization of stage 4 colon cancer in a 57 years old female for a period of nearly 4 years, with no serious toxicity. Since the natural history of stage 4 colon cancer consists of steady progression leading to disability and death, this case highlights a novel use of DCA as a cytostatic agent with a potential to maintain long-term stability of advanced-stage cancer.

A Novel Form of Dichloroacetate Therapy for Patients With Advanced Cancer: A Report of 3 Cases http://alternative-therapies.com/at/web_pdfs/s202khan.pdf

Oral dichloroacetate sodium (DCA) is currently under investigation as a single agent and as an adjuvant for treatment of various cancers. One of the factors limiting its clinical use in a continuous oral regimen is a doserelated, reversible neurotoxicity, including peripheral neuropathy and encephalopathy. The intravenous (IV) route has a number of potential advantages, including (1) pulsed dosing to achieve higher concentrations than feasible with oral use, (2) a longer washout period to reduce the potential for neurotoxicity, and (3) a bypassing of the digestive system, which is particularly significant for advanced-stage cancer patients. Data were available on high-dose IV DCA (up to 100 mg/kg/dose) that have confirmed its safety, both in healthy volunteers and in critically ill patients, allowing the authors to begin offlabel treatment of cancer patients. In several of their patients treated with IV DCA, the authors observed clinical, hematological, or radiological responses. This article presents 3 cases with patients who had recurrent cancers and for whom all conventional therapies had failed: (1) a 79-y-old male patient with colon cancer who had liver metastases, (2) a 43-y-old male patient with angiosarcoma who had pancreatic and bone metastases, and (3) a 10-y-old male patient with pancreatic neuroendocrine carcinoma who had liver metastases.

Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report. http://www.ncbi.nlm.nih.gov/pubmed/22580646?dopt=Abstract&holding=npg

DCA combined with OPZ and TAM exhibited more potent antitumor activity than DCA alone in HT1080 fibrosarcoma cells, but did not influence proliferation of WI-38 human fibroblasts. All these drugs induce caspase-dependent cell growth inhibition through superoxide production. Since they can be taken orally and have been used clinically without major side effects, it was thought that this combination therapy would be a readily translated strategy to treat malignant tumors. Under the patient’s consent these three drugs were prescribed to a 51-year old female cholangiocarcinoma patient to whom neither gemcitabine+S-1 nor adoptive immunotherapy with natural killer cells was effective. Disease progression was successfully blocked (the rise of serum CA19-9 value) for three months, also confirmed by CT.

Non-Hodgkin’s Lymphoma Reversal with Dichloroacetate https://www.hindawi.com/journals/jo/2010/414726/

In June 2007, a 48-year-old male patient, diagnosed with Stage 4 Non-Hodgkin’s Follicular Lymphoma (NHL), was treated for 3 months with conventional chemotherapy resulting in a complete remission. Almost one year later tumors returned in the nasopharynx and neck lymph glands. Refusing all suggested chemotherapies, the patient began self-administering dichloroacetate (DCA) 900 mg daily with a PET scan showing complete remission four months later. Since his last PET scan, May, 2009, he remains tumor-free from continuous DCA usage.

Prolonged Survival After Dichloroacetate Treatment of Non-Small-Cell Lung Carcinoma-Related Leptomeningeal Carcinomatosis http://www.journalmc.org/index.php/JMC/article/view/2456/1816

Here we present an observational case report of a 49-year-old female, non-smoker, having a poor performance status with non-small-cell lung cancer and leptomeningeal carcinomatosis (LMC), who upon introduction of oral dichloroacetate (DCA) survived approximately 64 weeks (454 days) following palliative whole brain radiation without the need for chemotherapy or further targeted therapy to specifically address the LMC. To our knowledge, this is the first case report incorporating the use of DCA in LMC. Our findings are discussed in the context of previously reported applications of DCA in malignancies of the central nervous system.

Mechanism:

For those familiar with the cellular metabolism, the mechanism behind DCA’s anti cancer effect is relatively straight forward. At least the main one as we understand today. Here is in a few words how DCA works:

Source photo: (Ref.)

  • Pyruvate dehydrogenase (PDH), is a complex of enzymes that converts cytosolic pyruvate to mitochondrial acetyl-CoA, the substrate for the Krebs’ cycle.
  • However, in most cancers, another enzyme called Pyruvate dehydrogenase kinase (PDK) (a mitochondrial enzyme) is activated and results in the selective inhibition of PDH.
  • As a result, instead of entering mitochondria, because PDH is inhibited, pyruvate can not go in so that it goes further down the glycolisis (fermentation) pathway and is finally converted in lactic acid
  • DCA has the potential to inhibit PDK, so that PDH can function again
  • When PDH works, pyruvate can be processed by mitochondria, so that the cell engine produces again energy (ATP) in a normal way and not via fermentation
  • When mitochondria works it produces Reactive Oxygen Species (ROS) as well. And it is known that high levels of ROS (such as H2O2) can inhibit tumor growth and result in apoptosis.
  • This is also the reason why, DCA helps chemo and radio therapy, since both of these treatment routes lead to increase of ROS. Normally, cancer cells produce a high level of anto oxidants to cope with the intracellular ROS, but once the ROS levell is to high (due to e.g. chemo and/or DCA) tumor cells will be killed.

Here are more details on how DCA works: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2567082/

Indeed, it has been shown that Dichloroacetate treatment improves mitochondrial metabolism, and the pyruvate dehydrogenase activity and the amount of acetyl-CoA in mitochondria was significantly higher after DCA treatment (Ref.)

It has also been shown that DCA induces autophagy in cancer cells accompanied by ROS production and mTOR inhibition, reduced lactate excretion, reduced k(PL) and increased NAD(+)/NADH ratio. The observed cellular and metabolic changes recover on cessation of treatment. (Ref.)

B1 vitamin and Alpha Lipoic Acid may act against cancer via similar mechanism as Dichloroacetate (Ref.1, Ref.2). However, I would not combine ALA with DCA. At least not in the IV form. Please read this comment to understand why https://www.cancertreatmentsresearch.com/dichloroacetate-dca-treatment-strategy/#comment-4502

As discussed shortly above cancer cells may become resistant to DCA. Two of the major reasons for resistance (and how to address them) are discussed in the next section below. Another reason for Resistance suggested by some of the most relevant scientist in the field may be the fact that in time, due to increase alkalinity of cancer cell, mitochondria may become totally dysfunctional or non-existent, in which case no matter how much DCA we would use, there will be no way for it to work (Ref: private communications).

Even when DCA can not effectively activate oxidative respiration via the mechanism described above, it may be able to kill cancer cells via a different mechanism that leads to accumulation inside the cytoplasm of high levels of citrate which in turn leads to the inhibition of glycolysis and inactivation of P-glycoprotein (Ref.). Inactivation of P-glycoprotein means that the cancer cells will not be able to push out chemotherapy and as a result, this also means that DCA can nicely support chemotherapy. Having this mechanism in mind, we can also argue that DCA theraphy works hand in hand with the Citric Acid therapy I discussed in another post: Citric Acid

How to increase the chance DCA will do its job? This is the most interesting part of the post to me.

Transport of DCA inside the cancer cells is essential … and not always there:

Dichloroacetate-induced apoptosis in cancer cells requires sodium-coupled monocarboxylates transporter SLC5A8 (SMCT1).  If the transporter is not expressed, cells may not accumulate the compound to levels sufficient enough to cause apoptosis. (Ref.)

Note that SMCT1 is the same transporter that is required for the anti-cancer effects of Butyrate supplements or Pyruvate.

However, SMCT1 it is epigenetically silenced in most tumour cells (Ref.), which could explain why high DCA concentrations should be used to achieve cytotoxicity in cancer cells. So, this is the reason why DCA doesn’t work for all cancers or if it works it is required at a high dose.

So the question is, how to reactivate SLC5A8 when that is inactive? Inhibitors of DNA methylation induce reactivation of SLC5A8. (Ref.) This means we need Inhibitors of DNA methylation. Fortunately, procaine is a DNA-demethylating agent with growth-inhibitory effects in human cancer cells. (Ref.) This is great, since procaine is accessible (easy to find in German pharmacies), cheap and safe. Procaine is used in alternative cancer treatment clinics in combination with Natrium Bicarbonate IVs and is also the main component in the well known anti aging drug Gerovital.

Now it becomes very interesting to me. I just found this paper stating the following “Knowledge on the regulation of SMCT1 at the intestinal level is very scarce. SMCT1 has been found to be inhibited by some NSAIDs (ibuprofen, ketoprofen, fenoprofen, naproxen and indomethacin), phytochemicals (resveratrol and quercetin), TNF-α, oxidative stress, chenodeoxycholic acid and by the absence of gut commensal bacteria. On the contrary, SMCT1 was found to be stimulated by some other NSAIDs (diclofenac, meclofenamate and sulindac), by activin A and by the probiotic Lactobacillus plantarum.” (Ref.)

Why is this so interesting to me? That is because the paper indicates that Diclofenac increases SMCT1 … and here is a funny story: My friend, stage IV cancer patient that saw his lung cancer gone when using DCA, once said to me that long time ago he had so much pain from his cancer … but he did not wanted to take Morphine. Instead, he used a lot of Diclofenac. I remember he said he took so much Diclofenac every day, like candies. And this was probably the key for such a good response to DCA he had. Unfortunately, not everyone can take a lot of Diclofenac due to the side effects related to the stomach, known to be characteristic to NSAIDs.

As you can see from above, Quercetin, Resveratrol and Ibuprofen should be avoided while on DCA.

It has been previously shown that Sulindac can indeed support DCA treatment, but the mechanism was explained in a different way (Ref.). However, possibly the main reason for the synergy between the two is actually explained above.

Not only transporters but also GSTZ1 expression and chloride concentrations are relevant for DCA effectivness:

Here is a paper published in 2016 that I find very relevant for understanding how to further improve DCA effectivness: “GSTZ1 expression and chloride concentrations modulate sensitivity of cancer cells to dichloroacetate” (Ref.). This paper indicates the following.

  • DCA is metabolized in the liver by the glutathione transferase zeta 1 enzyme (GSTZ1)
  • During metabolism of DCA, a portion of the GSTZ1 can be irreversibly inhibited by DCA
    slowing the clearance of subsequent doses of DCA
  • However, chloride anions can inhibit DCA-induced GSTZ1 inactivation
  • Some cancer cells (such as in breast cancer) over express GSTZ1 and confer resistance to the anti cancer effects of DCA
  • In addition in tumors chloride anions level is often abnormally high compared to the surrounding tissue
  • On this line, if the tumor expresses GSTZ1 and contains a high chloride anions level, the GSTZ1 will be stable, maintaining the resistance to DCA
  • As a result, co-treatment with compounds to reduce GSTZ1 expression or chloride anions level will reduce the resistance to DCA

This means that now we are in search for GSTZ1 an/or chloride anion trasnport inhibitors. Here are a few of those:

Well, now I understand why previous studies have shown synergy between DCA and Omeprazole (Ref.1, Ref.2). But this mechanism was not known in those studies.

On the other hand Bromide, iodide and sulfite also protected GSTZ1 from inactivation by DCA (Ref.). So we want to avoid them. Same counts for Quercetin that may increase chloride anion level in the cytosol (Ref.). Thus, while Quercetin has its own anti cancer effects, when using DCA is good to avoid its use.

Safety and Toxicity:

DCA can cause a reversible peripheral neuropathy that may be related to thiamine deficiency and may be ameliorated or prevented with thiamine supplementation. This is the main potential side effect.
In the majority of patients using it, DCA is well tolerated. Side effects are mild but can include fatigue, confusion, memory loss, sedation, tremors, hallucination, agitation, depression, heartburn (oral), and nausea (oral) (Ref.)
DCA is metabolized in the liver and as a result caution is required when administering DCA in cases of compromised liver function.

Pharmacokinetics:

Absorbed in the gastrointestinal tract and less than 1% of the total given dose is excreted in the urine; Metabolism of DCA occurs in the liver; DCA inhibits its own metabolism resulting in slower clearance from the body after multiple doses, which increases the potential for toxic effects; Although the halflife with the initial dose is less than one hour, this half-life increases to several hours with successive doses. There appears to be a plateau of this effect and DCA serum levels do not continue to rise with ongoing use (Ref.).

Administration:

Oral administration:

  • Start with 10mg/kg/day and increase slowly to about 25mg/kg/day (others are going to higher doses but I prefer safety instead – 25mg/kg/day is well tolerated (Ref.)). If neurophathy is emerging, reduce the dose slightly to below that level where it occurred. Here you can calculate the dosage depending on your weight http://www.thedcasite.com/dca_dosage.html
  • Use half of the dose in the morning and half in the evening
  • To avoid neurophathy use DCA during 5days/week and stop for the other two (others are using 2 weeks ON and one week OFF scheme)
    Update 12-March-2017: According to this article (Ref.) it is best to use the two weeks On and one week off scheme.
  • Use DCA until no evidence of disease
  • Preferably to drink by mixing the powder from capsule in water: https://www.youtube.com/watch?v=EbLqAFD7HaI. This is for better absorption.

IV administration

  • Up to 100mg/kg can be well tolerated (Ref.) I would however never jump to that high dose and start from 20mg/kg and best stop around max 70mg/kg max (Ref.). We used this dose with no issues but others may react differently.
  • Injected in 250ml NaCl bag, administered during 45 to 60 min
  • Administered 2x/week

DCA effect is dose dependent but there is a saturation level beyond which increasing the dose has no extra benefit (Ref.).

Additions to increase effectiveness or address potential side effects:

  • Caffeine: anecdotally, caffeine would increase effectiveness – I do not understand the mechanism behind this other than improving the micro vessel circulation
  • B1 Vitamine (thiamine) to reduce chance for neurophaty – some take 500mg/day, others up to 2500mg/day (Ref.). In addition B1 vitamin has its own anti cancer effect similar to that of DCA (Ref.1)
  • Procaine, Diclofenac or Sulindac to increase SMCT1  (see above)
  • Omeprazole 80mg/day to increase DCA effectiveness (see above)
  • Scorpion venom to increase DCA effectiveness (see above)
  • Metformin 1000mg to 1500mg/day (see above)

Source:

Oral:
Buyers should be aware that some companies may be selling fake DCA. One owner of a web-based company has already been convicted of internet fraud for selling counterfeit DCA http://www.cbc.ca/news/story/2010/06/01/con-dca-gaber.html As a result take care where you are ordering your DCA. One reader of this website (Emad) seeing positive results with his mom while using DCA and chemo wrote the following: “I tried this www.puredca.com, and this www.dcalab.com but the best results i had is when using this one www.dcacancer.org“.

IV:
IV form can be purchased from compounding pharmacies such as those listed here https://www.cancertreatmentsresearch.com/?page_id=945. However, it may be too expensive compared to the self made version. Because DCA is water soluble it can be easily prepared in IV form in the same way as 3BP (see 3BP IV section here https://www.cancertreatmentsresearch.com/?p=47). Depending on the dose used, self made version will cost <10 euro / dose.

References:

Role of SLC5A8, a plasma membrane transporter and a tumor suppressor, in the antitumor activity of dichloroacetate. https://www.ncbi.nlm.nih.gov/pubmed/?term=SLC5A8+dca

There has been growing interest among the public and scientists in dichloroacetate (DCA) as a potential anticancer drug. Credible evidence exists for the antitumor activity of this compound, but high concentrations are needed for significant therapeutic effect. Unfortunately, these high concentrations produce detrimental side effects involving the nervous system, thereby precluding its use for cancer treatment. The mechanistic basis of the compound’s antitumor activity is its ability to activate the pyruvate dehydrogenase complex through inhibition of pyruvate dehydrogenase kinase. As the compound inhibits the kinase at micromolar concentrations, it is not known why therapeutically prohibitive high doses are needed for suppression of tumor growth. We hypothesized that lack of effective mechanisms for the entry of DCA into tumor cells may underlie this phenomenon. Here we show that SLC5A8 transports DCA very effectively with high affinity. This transporter is expressed in normal cells, but expression is silenced in tumor cells by epigenetic mechanisms. The lack of the transporter makes tumor cells resistant to the antitumor activity of DCA. However, if the transporter is expressed in tumor cells ectopically, the cells become sensitive to the drug at low concentrations. This is evident in breast cancer cells, colon cancer cells and prostate cancer cells. Normal cells, which constitutively express the transporter, are however not affected by the compound, indicating tumor cell-selective therapeutic activity. The mechanism of the compound’s antitumor activity still remains its ability to inhibit pyruvate dehydrogenase kinase and force mitochondrial oxidation of pyruvate. As silencing of SLC5A8 in tumors involves DNA methylation and its expression can be induced by treatment with DNA methylation inhibitors, our findings suggest that combining DCA with a DNA methylation inhibitor would offer a means to reduce the doses of DCA to avoid detrimental effects associated with high doses but without compromising antitumor activity.

A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth. http://www.ncbi.nlm.nih.gov/pubmed/17222789

The unique metabolic profile of cancer (aerobic glycolysis) might confer apoptosis resistance and be therapeutically targeted. Compared to normal cells, several human cancers have high mitochondrial membrane potential (DeltaPsim) and low expression of the K+ channel Kv1.5, both contributing to apoptosis resistance. Dichloroacetate (DCA) inhibits mitochondrial pyruvate dehydrogenase kinase (PDK), shifts metabolism from glycolysis to glucose oxidation, decreases DeltaPsim, increases mitochondrial H2O2, and activates Kv channels in all cancer, but not normal, cells; DCA upregulates Kv1.5 by an NFAT1-dependent mechanism. DCA induces apoptosis, decreases proliferation, and inhibits tumor growth, without apparent toxicity. Molecular inhibition of PDK2 by siRNA mimics DCA. The mitochondria-NFAT-Kv axis and PDK are important therapeutic targets in cancer; the orally available DCA is a promising selective anticancer agent.

Differential inhibition of PDKs by phenylbutyrate and enhancement of pyruvate dehydrogenase complex activity by combination with dichloroacetate http://link.springer.com/article/10.1007/s10545-014-9808-2/fulltext.html

Pyruvate dehydrogenase complex (PDHC) is a key enzyme in metabolism linking glycolysis to tricarboxylic acid cycle and its activity is tightly regulated by phosphorylation catalyzed by four pyruvate dehydrogenase kinase (PDK) isoforms. PDKs are pharmacological targets for several human diseases including cancer, diabetes, obesity, heart failure, and inherited PDHC deficiency. We investigated the inhibitory activity of phenylbutyrate toward PDKs and found that PDK isoforms 1-to-3 are inhibited whereas PDK4 is unaffected. Moreover, docking studies revealed putative binding sites of phenylbutyrate on PDK2 and 3 that are located on different sites compared to dichloroacetate (DCA), a previously known PDK inhibitor. Based on these findings, we showed both in cells and in mice that phenylbutyrate combined to DCA results in greater increase of PDHC activity compared to each drug alone. These results suggest that therapeutic efficacy can be enhanced by combination of drugs increasing PDHC enzyme activity.

Metabolic plasticity in cancer cells : involvement in the processes of proliferation and response to radiotherapy http://dial.uclouvain.be/handle/boreal:171100 http://dial.uclouvain.be/downloader/downloader.php?pid=boreal:171100&datastream=PDF_01

While pioneering studies suggested that enhanced glycolysis, a hallmark of cancer, was caused by an irreversible impairment in mitochondrial respiration, more recent data reported functional mitochondrial activity in many cancer cells. In this thesis, we thus intended to investigate whether metabolic modulations could improve the therapeutic outcome of cancer. We found that dichloroacetate, a new clinically tested compound, induced a switch of glycolytic cancer cells to a more oxidative phenotype, and decreased tumor cell proliferation through a decrease in the activity of the pentose phosphate pathway. In a second part of this work, we investigated whether targeting mitochondrial respiration with H2S, the last gaseous transmitter identified in mammals, improved tumor response to radiotherapy. By rapidly alleviating hypoxia inside solid tumors, the single injection of a H2S donor increased the radioresponse of cancer in mice. Overall, our thesis work emphasizes the ability of cancer cells to remodel their energetic metabolism in response to external stimuli and supports that both glycolysis and oxidative phosphorylation are attractive targets for cancer therapy.

Metabolic Modulation of Glioblastoma with Dichloroacetate http://stm.sciencemag.org/content/2/31/31ra34.abstract

Solid tumors, including the aggressive primary brain cancer glioblastoma multiforme, develop resistance to cell death, in part as a result of a switch from mitochondrial oxidative phosphorylation to cytoplasmic glycolysis. This metabolic remodeling is accompanied by mitochondrial hyperpolarization. We tested whether the small-molecule and orphan drug dichloroacetate (DCA) can reverse this cancer-specific metabolic and mitochondrial remodeling in glioblastoma. Freshly isolated glioblastomas from 49 patients showed mitochondrial hyperpolarization, which was rapidly reversed by DCA. In a separate experiment with five patients who had glioblastoma, we prospectively secured baseline and serial tumor tissue, developed patient-specific cell lines of glioblastoma and putative glioblastoma stem cells (CD133+, nestin+ cells), and treated each patient with oral DCA for up to 15 months. DCA depolarized mitochondria, increased mitochondrial reactive oxygen species, and induced apoptosis in GBM cells, as well as in putative GBM stem cells, both in vitro and in vivo. DCA therapy also inhibited the hypoxia-inducible factor–1α, promoted p53 activation, and suppressed angiogenesis both in vivo and in vitro. The dose-limiting toxicity was a dose-dependent, reversible peripheral neuropathy, and there was no hematologic, hepatic, renal, or cardiac toxicity. Indications of clinical efficacy were present at a dose that did not cause peripheral neuropathy and at serum concentrations of DCA sufficient to inhibit the target enzyme of DCA, pyruvate dehydrogenase kinase II, which was highly expressed in all glioblastomas. Metabolic modulation may be a viable therapeutic approach in the treatment of glioblastoma.

Dichloroacetate and cancer: New home for an orphan drug? http://www.ncbi.nlm.nih.gov/pubmed/25157892

We reviewed the anti-cancer effects of DCA, an orphan drug long used as an investigational treatment for various acquired and congenital disorders of mitochondrial intermediary metabolism. Inhibition by DCA of mitochondrial pyruvate dehydrogenase kinases and subsequent reactivation of the pyruvate dehydrogenase complex and oxidative phosphorylation is the common mechanism accounting for the drug’s anti-neoplastic effects. At least two fundamental changes in tumor metabolism are induced by DCA that antagonize tumor growth, metastases and survival: the first is the redirection of glucose metabolism from glycolysis to oxidation (reversal of the Warburg effect), leading to inhibition of proliferation and induction of caspase-mediated apoptosis. These effects have been replicated in both human cancer cell lines and in tumor implants of diverse germ line origin. The second fundamental change is the oxidative removal of lactate, via pyruvate, and the co-incident buffering of hydrogen ions by dehydrogenases located in the mitochondrial matrix. Preclinical studies demonstrate that DCA has additive or synergistic effects when used in combination with standard agents designed to modify tumor oxidative stress, vascular remodeling, DNA integrity or immunity. These findings and limited clinical results suggest that potentially fruitful areas for additional clinical trials include 1) adult and pediatric high grade astrocytomas; 2) BRAF-mutant cancers, such as melanoma, perhaps combined with other pro-oxidants; 3) in which resistance to standard platinum-class drugs alone may be overcome with combination therapy; and 4) tumors of endodermal origin, in which extensive experimental research has demonstrated significant anti-proliferative, pro-apoptotic effects of DCA, leading to improved host survival.

Sensitization of breast cancer cells to paclitaxel by dichloroacetate through inhibiting autophagy http://www.sciencedirect.com/science/article/pii/S0006291X17309786

Chemotherapy is still the main adjuvant strategy in the treatment of cancer, however, chemoresistance is also frequently encountered. Autophagy inhibition has been widely accepted as a promising therapeutic strategy in cancer, while the lack of effective and specific autophagy inhibitors hinders its application. Here we found that dichloroacetate (DCA), a small molecule compound, could significantly inhibit the autophagy induced by Doxorubicin in breast cancer cells. And DCA markedly enhances Doxorubicin-induced breast cancer cell death and anti-proliferation in vitro. But the sensitization to Dox of DCA was significantly reduced through induction of autophagy by rapamycin. Moreover, the combined therapy of Dox and DCA could significantly inhibit tumor growth in vivo and prolong mouse survival time. Taken together, we demonstrate that DCA could inhibit doxorubicin-inducing autophagy and provide a novel strategy for improving the anti-cancer efficacy of chemotherapy.

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

Please read an extended version of the Disclaimer here: https://www.cancertreatmentsresearch.com/?page_id=1794

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358 Comments on "Dichloroacetate (DCA): Effective, Cheap & Accessible Drug to Fight Cancer"

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Ergin
Member

Dear Daniel,

Great work,perfect work.Thank you very much for all of us.
If you wish i can begin to write here our treatments after DCA alone(shortly).
As i can see we are only 3-5 people using DCA ,we need to attract more peoples attention to learn from their experiences
and to help others.

May be we can find a good combination treatment with DCA in one day.

Kind Regards

Ergin

Jason
Guest

You can make that 6!

Ergin
Member

Hi Jason welcome,
I hope you have good news about DCA.

anna
Member

Dear Daniel,
Thank you for your once again great article.
As mentioned above ALA plus vit B1 have the same effect as DCA.
As DCA has to wait because of liver that doesnt work to good, ALA helps regenerate liver so is perfect for us.
I use flaxseed oil in Budwig ‘s pap. Flaxseed has a lot of ALA. Or it has to be in pills.
I wonder about doses.

Ergin
Member

Hi Anna,
How do you use ALA?
I have to search for it.Could you please write your experiences shortly about it?
Did you try DCA before?If yes did you see some good results with ALA or DCA?
Thanks
Ergin

anna
Member
hi Ergin and of course hi everyone, Sorry for so long time to answer but I had technical problems to answer. I wrote a post and couldn’t post it. Now I am back at home so I hope I will not have problems to post. Unfortunately I can not share too much because I estime my experience is very poor. I used few things but there wasn’t nothing which really worked 🙁 . I also found thus page just before my husband started to have problems with liver after SIRT so a lot of therpaies are not for us because… Read more »
anna
Member

No ergin, no DCA up to now.
One box is waiting for its time but for the moment too toxic for liver.
ALA was also not in so big doses to see effects I believe.
I have to say my husband is very difficult to take all supplements I ask him. It is always a fight and I cannot control him if when Ia ma at work he takes it or just throw it away.

Ergin
Member

Hi Ann,
Thank you very much for your message.
I hope everything will be fine for him.

Alex
Member

Dear Ann

Are you trying DCA, B1? ALA?
Are you trying Budwick?

How are things? I hope something is working.

Best wishes,
Alex

Ergin
Member

Dear Daniel,

I have found 2 different cases, they use both DCA and ammonium tetrathiomolybdate for controlling copper deficiency.
Do you have any experience with those 2 combinations.?Especially for ammonium tetrathiomolybdate(TM).
In one case it works alone without DCA!!!
http://medicorcancer.com/metastatic-ovarian-carcinoma-case-1/
http://medicorcancer.com/metastatic-ovarian-carcinoma-case-2/

Kind Regards
Ergin

Emad
Member
Thank you Daniel for this great article on DCA I noticed a lot of information that I was not aware of , especially about how to make DCA work better if the resistant happened yesterday the tumor marker results shows a little decline , from 381 to 353 , I was using DCA and chemo also the DCA version that I was using shows a little effect , of course I returned to use the old DCA from dcacancer.org , that is the one that I used to have a very good results with it , but also maybe I’m… Read more »
Ergin
Member

Thank you Emad,
I also wish you a happy new year.
I wonder do you use TM or Thalomide or another angiogenesis inhibitor with DCA?

Ergin
Member

Hi Friends,
Sorry for late update.I was travelling.
We took the blood count results on saturday .
CA125 rised from 21 to 28 in 15 day with DCA alone 600 mg/day.
We began 600×2 mg/day on saturday and waiting for the results.

Ergin
Member

Last results on DCA :
CA125 stopped rising and declined to 27,after 4 days with 23mg/kg/day.

Emad
Member
Hi Ergin , I hope you have better and better results in the upcoming days DCA is dose dependent , I remember when I lowered the dose everything went wrong today we have done a CT Scan , the bone mets are stable (also became more dens) and there is moderate regression of the liver mets that’s the good news ————— but I’m little concerned about the liver enzymes test ASAT and ALAT used to be always on the range of 15 to 30 but now they are 45 and 46 also GGT (Gamma glutamyl transferase) and PAL (Phosfatase alcalines)… Read more »
Ergin
Member
Hi Emad, I dont know where to begin but i have different news today. I went to a company who sells collodial silver.They are not amateur. We talked for 2 hours about collodial silver. He said that use it and forget about cancer.He has lots of good feedback about cancer patients.(80 percent he said). May be you catch from some of my messages that i am searching for nano silver for months. He always gave silver to his small daughter when she is ill and never went to a doctor. But they are seller,i never forget. In Georgia collodial silver… Read more »
Ergin
Member

I forgut to write Collodial silver is a good glutathione and copper chelator.
I have to find someone to learn how to use it.
I bought 1 lt for 20 usd. it is for 15 days he said.First keep it under tongue for 8-10 minutes,then drink.
25ml x3/day.If she doesnt have high blood pressure ,use it with MMS.But she has high blood pressure.
But i have to learn more about it before using.

Eddie Lam
Guest
Emad, I’m really glad to hear that your CT scans are good and that you see the improvement on the liver metastases. Regarding the question about ASAT and ALAT – it’s not that much big of a deal to have 45 and 46. It shows extremely mild breakage of liver cells, may as well be due reduction of liver metastases and their lysis. In comparison, people with Acute Hepatitis have 100, 200 or even more of ASAT and ALAT. About one out of ten drugs cause liver toxicity and liver enzymes to rise. You’re probably getting elevated levels because of… Read more »
Emad
Member

thank you so much Eddie

this really makes me feel better and not worried so much

yes also DCA seems to increase the liver enzymes

I was happy after the CT scan but since that time everything went wrong , the markers last time is 607

I don’t know how much it could be increased or changed , hope nothing bad happened

also , tomorrow I’m gonna face my nemesis , its the dark scary horrible adrenaline day

God give me strength

Ergin
Member

Please all friends has to read.
http://link.springer.com/article/10.1385/BTER:82:1-3:001
This shows us the importance of cupper depletion.

anna
Member

How you chelate copper?
And should we then supplement with zinc?

Ergin
Member

Hi Ann,
Yes we can deplet copper by TM with dose and time dependent.I am sorry because i wrote in wrong place.
The true adress should be this.
https://www.cancertreatmentsresearch.com/?p=249

Ergin
Member

Hi Ann,
How are you and your husband?Hope everything is fine for you and him.
You said he has to give a break to maraviroc because of travelling and diarrhea,if i true remember.
Have you experienced stg positive or negative?
Is erbitux still working after break?
Kind Regards
Ergin

.

Emad
Member

Hi Ergin , sorry to hear about your challenges , why did you stopped chemo ?

how is your mother ? hope she is fine

for me I can’t relay on DCA or any other treatments alone without chemo , if I stopped chemo I may use something like MG

I wish things go well soon

Ergin
Member

Hi Emad,
Thank you very much ,she looks fine and feels fine but we dont know the inside.
Only i can say that she has lots of gas in intestines,i hope thats because of collodial silver NOT from ascites.
Tomorrow is big day.Blood counts…
MG and TM is on the way from Sigma.They said 4-6 weeks to arrive!!!
We are going to begin chemo this week.
Emad,do you have experience about heparin?
And did you use thalidomide or TM or MG?
Kind Regards
Ergin

anna
Member

Hi Ergin, we had no scans or CEA yet done but bilirubin fell down and liver function improves. So I hope it works. I added honokiol from Honopure now at 1.5 g per day. I want to write soon (with help of Daniel if he agrees )article about honokiol. Looks very promising to me.

I do not know yet date of scans to see if Erbitux and Maraviroc still working good.

Ergin, I saw it is not going good way in your mum case. Do you have any new ideas? Did you consider Maraviroc?

Ergin
Member

Here it says ,ceruloplasmin levels can be a prognostic value like CA 15,3
http://www.tandfonline.com/doi/pdf/10.3109/02841869209089716

Ergin
Member

Daniel
there is stg wrong with your web site

Ergin
Member

Or We could not attract peoples attentions?
Cancer is serious ,am i wrong?
I am going to think like I AM the last person about thinking about a CURE!!

Carl
Member

A case report describing toxicity of DCA + artesunate combination in a GBM patient
http://btcocktails.blogspot.co.za/2016/10/toxicity-of-dca-artesunate-combination.html

Ergin
Member

Dear Friends,
DCA alone does not worked for us.
CA 125 rised to 45 unfortunately.
Pain on abdomen and bowel movements are not good.

Meech
Member

http://cancerodds.org/dca-sodium-dichloroacetate-metformin/

This article might help. It shows DCA in combo with other compounds. It also corroborates what you say about DCA as a standalone. I’ve never been high on DCA on its own.

EGCG as far as I’ve heard, inhibits some pathways to cancer cells using glutamine for gluconeogenesis, and IMO could be useful to use in conjunction with DCA. Also, without question, I would start Metformin along with it.

Alex
Member

Dear Meech, the article you linked shows that we should not have cafeine with DCA+Metformin, i understand from other sources that cafeine is recomended.
Any opinions anyone?

Alex

Meech
Member

Caffeine has been a somewhat controversial part of DCA therapy. Some claim it’s dangerous, some claim there’s efficacy, and others claim there’s no effect.

I personally haven’t tried it, and I don’t drink coffee so I’m not sure whatsoever.

Wondering
Guest

hi Meech, i read somewhere you have been on dca for one year. how much do you take per kg? Which source do you trust the most ? does it seem to work for you? cheers, W

Meech
Member
Hi Wondering, As to whether it works for me: I started taking it late March 2016, after being on a regimen of capecitabine + temozolomide for 3 months and nothing else. My liver tumours grew to about 5cm, 3cm, 2 cm, and under 1cm while on the CAPTEM. Other tumours grew a bit too; most notably an external iliac node grew to about 2.4cm At this point I started Keto + metformin + DCA 25mg/kg and some other natural stuff. I went to Germany for TACE with Prof. Vogl who said I had an amazing response (all liver tumours eliminated).… Read more »
Meech
Member

Sorry, the tumour giving me issues is the external iliac node, not supraclavicular. I have also increased the dose to 31mg/kg as of a month ago.

My source is Dr. Akbar Khan from Medicor as we are in close proximity to each other.

I have mild neuropathy I would say. If I keep my arm in a particular position for too long, it’ll numb. But in general, nothing really.

Wondering
Guest

much (meech) respect to you, Meech.
what did you receive via TACE? did your cancer start in your liver?
how about adding some light chemo; ldn, chloroquine, mebendazole, cimetidine etc to keto, metformin and supplements?

Wondering
Guest

and of course ala+ hca if that is not already taken by you

Meech
Member

Thanks W.

TACE was performed with 9.85mg Mitomycin C, 994.98mg Gemzar, 50.94mg Cisplatin. I believe I had 6 sessions to the liver, followed by 2 sessions of microwave ablation to eliminate the residual disease.

I believe I’m going to start with some dose of carboplatin + diclofenac + chloroquine + DCA + Metformin + Keto + Artemisinin and some natural supplements. Possibly a PPI on some schedule so as to not interfere with carbo.

Wondering
Guest

probably its already taken by you but i read that resveratrol is making cells more sensitive to cis -, and carboplatin, just like DCA by the way.

Re ketogenic: I try to do this too. While i dont really miss pasta, bread etc. i do miss beverages… I saw spirits do not contain any CH at all- do you think its ok to drink spirits while on keto? the info online is not really straight on this…

Meech
Member

As far as I can see, spirits don’t have any carbs or sugars. So in terms of Keto, they should be okay.

However, I don’t know how “okay” they are for cancer patients. I believe that alcohol can contribute to systemic inflammation. It also does have an impact on hormones.

I’m unsure about alcohol. I personally decided to quit drinking when I was diagnosed so I don’t think I’m too much help in this department.

Wondering
Guest

It was a good decision, its indeed inflammative, but i meant in small amounts only, IT would be bad to come out of ketosis because of one single beer or two. Thanks for your answer, i agree with u.

Wondering
Guest

i meant shots not beer:)

Wondering
Guest

hi Meech ,

you have cancer starting from the liver, right?

did you try japanese chlorella as a supplement? below is an animal study for liver cancer, but i heard that some japanese oncologists (maybe Dr Hada can jump in here) recommend Chlorella to cancer patiens.

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2613958/

damages the DNA too
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3020351/

Meech
Member

Hi Wondering,

It actually presumably started in the kidney, although it’s poorly differentiated so that’s likely an educated guess in terms of the origin. I’ll look into this substance anyway though, thanks!

Alex
Member
Dear ergin With great hope i write to you here that maybe this will help your mother just as it did for my mother. Coffee enemas will help a great deal with pain and bowel movements i am surre. I fail to see any significant downside to the enema procedure or effects. Let me just say that enemas have saved my mother’s life in the past and i am sure of it. I was but a kid and used to check if my mother was still breathing at night, in basic terms her boddy was very very toxic. Once she… Read more »
Ergin
Member

Dear Meech,

Thank you very much for your message.You always want to help people.

Sorry for writing DCA standalone.I mean DCA without chemo.
We used metformin,2DG,curcumin with DCA.
But CA125 is rising day by day.I hope the cause of the rise is coming from the
proteins released from dying cells.But very litlle chance.

Kind Regards
Ergin

Meech
Member

Ah man, sorry to hear. I wish I knew what drove resistance to these compounds.

Ergin
Member

Hi Meech,
Although her CA 125 is climbing(doubled in 10 days after we switched to 600mgx2) ,
LDH:75
CRP:1.2
Ceruloplasmin:25
The other blood counts shows no progress.(My opinion)
I am searching and searching but couldnt find the answer.
Dou you have any experience about LDH and DCA?
May be there is stg going positive.
Kind Regards
Ergin

Meech
Member

Unfortunately I don’t know too much about LDH. I know mine has been all over the place at random times. My highest value was just after TACE.

Ergin
Member

We got the blood tests.
Unfortunately ca125 rised to 54.

Emad
Member

sorry to hear that ergin

when you will start chemo ? it will do the job especially with other treatments

4 to 6 weeks is good , chemo will do the job until they arrive

why do you think gas is from ascites ? there is a lot of things can cause the same

Ergin
Member

Hi Emad,
Thank you very much for your message.
We are going to dr tomorrow.He asked for a gene sequencing.
I send her blood to 3 different labs.CA125 is 85 in other 3.(NOT 54)
So from 2 months we were wrong about the ca125levels.
BUT i looked her past LDH levels and found that it was always higher than 200.Now 100.
DCA ,metformin and 2dg is working i think,.Her inorganic phosphor is high also more than 5.
I am thinking of necrosis but why CA125 is still rising?
I think it is just time to fight with chemo with this low LDH.

Alex
Member

Dear ergin
My mother’s CA 19.9 on our first test was 17.2, CEA levels did rise from 28.05 to 43.05 but the LDH levels stayed the same 148
These tests were made at a 20 day interval.

I am also wondering if this could point to necrosis.

Any news?

Bes of Luck!
Alex.

Alex
Member

I forgot to say that CA 19-9 raised from 17.2 to 18.2

Ergin
Member
Hi Alex ,my phone charge is nearly finished. I am 500 km far from home.Your words affected me too much.We have to talk more about your mom. Dont do our falts. When you take chemo 1 time,everthing about immunoteraphy changes. Genes are changing. You can try lots of things because she didnt take chemo. I have a friend who never took chemo. You should try immunoteraphy. If you wish send a clear mail to Daniel, He will open a new post for you. It helps you too much. And what i understand in 2 months in here is:dont write too… Read more »
Alex
Member

My dear ergin, i look forward to talking to you more, when you have some time.
Thank you so much for your reply here.
My best wishes go with you and everyone else reading.
Good luck in your adventure with all this, we all need it.

Alex

Ergin
Member

Hi Alex did you try artemisinin?
There is a village around here,a man cured some people with it,a legend.But on news i saw 2 years ago.Although he didnt sell it,they put him in jail just like the man with nerium oleander.
It is very important to know which gene changed some doctors says?May be you can repair or go over that treatment.

Alex
Member
Dear ergin, we tried the plant tea and plant capsules, for a couple of weeks. Because i saw no positive change in my mothers state, only bad. We stopped that and we started aspirin+cbd oil. That worked great for a while, at least in my mothers mood, she had very little pain. Maybe Artemisinin would work in some combination or higher dose, IV…. i don’t know. I am wondering what you wanted to say when you said “don’t do our falts”. Imunotherapy is extremely expensive, i am doing my best to try and help my mother with what i can… Read more »
Ergin
Member
Hi Alex, I dont want to mix peoples minds but my thoughts about chemo is very bad.As i said before once you take it,everthing changes on cells.It kills some cancer cells but also developes cancer stem cells.Multi drug Resistant cells. It is there,you can use it later.First try different things.This is what i wanted to say. She took oleander with chemo.First perfect worked,than no fever occured,because high dose chemo killed immunity. Than i met Daniel….And our life changed.I understand the importance of METABOLIC TREATMENT. I always add 1 drug to protocol,if it works alone or not.That was a very big… Read more »
Alex
Member
It’s very very late here for me but i wanted to say a few things before and then i will come back to this and continue. I have a theory based on 4+ months of reading about this problem. A tumour is made up of similar but slightly different cells, some die with a treatment, the others do not. and markers go down a little. Please look here https://youtu.be/lpytoIxRu0o It’s a computer simulation of a tumour. My theory is that some parts of the tumour will die with a treatment, others will not and would require other treatment. Or else… Read more »
Ergin
Member

Dear Alex,
Please never feel bad when i asked for helping.The aim and the name is foundation as you see.
If i need help,i will ask for friends here.For example i need thalidomide:).If someone can send,i would very happy.
Never forget Alex,we are more than friends here.We are sharing pain and happiness.We are looking for new treatments and if Daniel finds a new treatment,we are happy alltogether:)
Donating foundation is better i think.Or waiting for what Daniel says.

Helga
Member
Hi Alex, I know for a fact (scientific evidence as Alberto would say) that the tumor/cancer genome undergoes a Darwinian-type evolution over time. I.e. there are mutations all the time and there is a selection process going on with the fittest to survive. Depending on what the tumor faces (what treatments and other microenvironments it comes across) it will mutate accordingly. As chemo is a very strong signal for the tumor to die, whatever survives will be all the more strong. Do you remember the Nietzsche saying “whatever doesn’t kill you, will make you stronger”? Well, it could not be… Read more »
Tanya
Guest
Hello, I have been following everybody’s posts with great interest. I do not have much to contribute yet. I have rare, aggressive ovarian cancer in advanced stage. I have last cycle of my frontline chemo to finish. I take metformin 500 mg daily. During my 5th cycle I added horse chestnut to potentiate chemo but it did not help and my CA 125 is plateauing. I was talking about Salinomycin with Daniel but decided against it for right now. I understand that DCA is a good option if you have tumors light up on a PET scan. My last PET… Read more »
Ergin
Member
Dear Daniel, Thank you very much for searching and the links. There are some clinicals trials on statin and have different results.Most of the secientists are agree with intraperitoneal infusion of drugs for peritoneal cancer.(IP) Iv or oral drug does not give benefit on overall survival..Periton is a very different organ.Tumors may find different ways for feeding on periton.From periton fluid maybe. For example targeting VEGF by anti-antiogenic strategy dont do anything to the tumors on periton in mouse models.But shrinks the other tumors on abdomen. May be our solution is IP.Do you have any idea about IP? Tumors will… Read more »
Ergin
Member

Thank you very much Daniel for helping.

Adina
Guest

Dear Daniel,

Thank you for everything you have done and do. I have read your answer to Tanya. I have a similar situatiion with my husband. Colon cancer, no tumora seen on PET, but cancer îs stil there. It was seen lymph nodes near lungs.What approch do you see, the best? Targeting mithocondrya ? What else?
Thank you.
Adina

Helga
Member

Daniel, my comment was taken for spam. I hope you can resurrect it because it is gone now.

Ergin
Member

Hi Daniel,
As you know we tried DCA with collodial silver for 1 week and didnt get any positive result.
But that days i gave collodial silver(CS) to my friend who is a valuable bird collector.
He has a bird which was very ill.Some tumors on body,1 eye closed,no hair on head.
He has put some drops of CS in its drinking water.Sprayed on body and head.
After 1 month past he called me today that the bird is healed.Hairs begin to grow,no tumors visible.
Ofcourse we dont know it was cancer or not and it is not human,but isnt it highly interesting?

Alex
Member
Dear friends. I keep wondering if DCA could be be enhanced with the Budwick diet in adition to the other things that are talked about in here. The coffee enemas seem to be highly beneficial in my mother’s case, she instantly felt better. I know the science behind budwick and the coffee enemas is lacking, i wish not to suggest but only to inquire and learn about your experience. Adina may be on to something here, i’ve been thinking about it myself. It may make huge sense to do coffee enemas in the case of colon cancer, no suggesting it,… Read more »
Jcancom
Member

Very big day today!
Mark February 28th 2017 on your calendars!

Kite Pharmaceuticals reported very strong results for its Car T Cells in lymphoma.
Trial also underway in leukemia.

So much great news out there!
H. phylori vaccine was found safe in 2015.
(Up to 85% of stomach cancer found related to H. pylori)

Article recently published suggesting that prostate cancer might relate to female menopause
and consequently might be preventable with anti-bacterial treatment.

Very good news out there!

Ergin
Member
It is very clear that why collodial silver is highly Cytotoxic to some cancer types.Because it kills all bacteria.But nanoscale.Not CS done at home. I believe future treatments will all be on nano particles.100 ‘s times powerful than big particles now we use in all medicines. If it is nano sized it enters easily to cells. Dear J. You are a good researcher,when i read your messages,i look arround is there any camera or not arround me:)We exactly are reading same articles. Let me tell my idea: Magnetic nano particles loaded with medicine. If the tumor is palpable it is… Read more »
Alex
Member

Ergin reported bad results with DCA, he mentioned he was also giving his mother Curcumin, i wonder if that’s ok since Quercetin is to be avoided.
What about Ginger?

Just to be sure, are we talking about plants or extracts?

Best wishes,
Alex

Emad
Member
Hi Daniel , Ergin Hope you are both fine today my father went to a clinic in Germany , I don’t know about the clinic but he went to a doctor specialized oncologist treating breast cancer patients , he suggested to pay them about 4500 euro for diagnostics ( like knowing about the gene expression and the details about the tumors type .. etc) Then maybe he will use a therapy that will target multiple hormones (if the tumor is sensitive to hormonal therapy) and also may ues enzyme therapy to target the liver mets , he also may use… Read more »
Ergin
Member

Emad i have good news for you.I found procaine here.They use it for lab ,the phamagist said.I will work on it.
And one more thing.I learn everything from Daniel,please ask technical questions to him:)

Emad
Member
Thank you so much my brother Ergin , I will wait for my father’s answer , maybe he can find time to bring it from Germany if he didn’t find it then I will try to find a way to get it with your help I already asked Daniel and he is always helping me all the time , I hope you can give IVs to your mother at home , try to do it with safe treatments , once you succeed you will have the ability to access stronger treatments like 3-BP + Diflu + Sal and use them… Read more »
Emad
Member

I put a comment, is it still there as a spam ?

Mart
Guest

Hello, I’m new here
I am in Australia and unfortunately shipping of DCA takes many weeks coming from standard international suppliers. I found a source in Australia
http://trustedhealthsupplies.com.au/
Has anyone used these guys before? I’d love to have a product review.

Alex
Member

Dear friends, Daniel.
Would there be anything of value in this video for us? https://www.youtube.com/watch?v=8uY3bfU3vG4
It’s about DCA and you may or may not be familiar with it already.
Thank you very much.
Alex

Meech
Member

I was just reading this article. I know it’s Mercola, but it features some impressive thoughts about what Turkish doctors are doing with metabolic therapy as an adjunct to lower dose cytotoxic drugs.

http://articles.mercola.com/sites/articles/archive/2017/03/12/metabolically-supported-therapies-cancer-treatment.aspx

I think it’s a quality read (it’s a little long).

Alex
Member

Thank you Meech
I wonder if metformin removes the need for the ketogenic diet or not.

Meech
Member
Hi Alex, Metformin lowers blood glucose levels in part by inhibiting the Cori Cycle in the liver. This cycle converts excess lactic acid back into glucose. I personally think Keto and Metformin are good adjunctive therapies but Metformin wouldn’t cover the entire scope of lowering BG. Also, the benefit to Metformin does far exceed its ability to lower BG. Secondarily, I don’t think a low blood glucose necessarily results from a Keto diet. I’ve been on the diet for about a year now, pretty strictly, and my BG remains within normal parameters. Even while fasted. I can’t remember why exactly… Read more »
Ergin
Member
Dear Meech, That clinic belongs to 2 doctors and Dr. Abdul Kadir Slocum(right on photo)is their student there. He will be good doctor.He is American origin. Prof Bulent Berkarda(first oncologist in Turkey)and Dr Salih Kesici are 2 doctors in the same clinic. They said they have a record on survival of pancreas ca. They use iv mannose,iv sulphur,iv iron,iv vitc+HBOT+hyperthermia+2DG+quercetin+artemisinin+beta glucan+curcumin injections+melatonin+metformin+DCA.They have salinomycin but didnt try yet. They always said please force your mother to enter HBOT.And they show me very good pet results only with HBOT. I will go near them this week,because i want to talk about… Read more »
Meech
Member

Hi ergin,

Thank you for the information; their progress is something I’ll definitely keep an eye on as I firmly do believe that there is a place for chemotherapy.

Absolutely, if you could please ask them:

– the schedule when administering anti-glycolytics (does it matter if DCA, etc. Is given concurrently on the same day as therapy and beyond or if there are days to withhold it.)

– what form of ketogenic diet they’re implementing. How many grams of protein per kg. Thoughts on consumption of meat products.

– dosages of the glycolytic inhibitors if possible.

Thank you very much ergin.

Meech
Member

Does anybody have any experience with higher doses of DCA? I’m talking 35mg/kg and up. I have progression with about a year of 25mg/kg, along with other therapies (albeit growing much, much slower than you would anticipate for an 80% Ki67% cancer), and was thinking of taking it up a notch experimentally.

Alex
Member

Hi Meech, i presume you aren’t using chemo.
Anything else you use besides ketogenic diet and DCA?

Meech
Member
I have not been on chemo since June of 2015. I received 8 TACE sessions and 2 sessions of microwave ablation from Dr. Vogl for liver mets, which was highly successful. Apart from the DCA and Keto, I take Metformin; Melatonin; took 2DG while undergoing TACE but constant use proved expensive so I have not been on it in some time; EGCG; Graviola, Propolis; Ashwagandha, Astragalus; Milk Thistle. I was previously taking Artemisinin but stopped for a while because the amount of liquid was somewhat too much. I have restarted again at 3 cups of cold-steeped artemisinin tea daily about… Read more »
Alex
Member
Thank you meech, i am curious what graviola are you taking? And how much of it? I noticed mother feeling better with it, so i ended up spending a lot of money on graviola tea powder and paw paw capsules. 1kg of such tea powder. Sadly her feeling better seems to only have been a strange ilusion of sorts. CEA level raised from 28,05 to 46,05 in 20 days of using it at 50g of graviola leaf powder tea+6 capsules of paw paw each day. This was a standalone treatment. Congrats on your achievement with the ketogenic diet. Keeping the… Read more »
Alex
Member

So it is my understanding you take DCA+Artemisini correct?
Please check my other reply here.
Thank you very much,
ALex

Meech
Member

Hi Alex,

Yes, I’ve re-started artemisinin a few weeks ago, and I do take it with DCA. I know somebody said there might be a risky interaction there but I haven’t seen any issues thus far, with a high dose of DCA.

I steep the full plant/dried leaves in cold water overnight and drink it three times per day. I drink it five days per week.

Alex
Member

So…. should curcumin, ginger, resveratrol be removed from the protocol when using DCA? Just to be sure asking.
Should i get procaine?
Would Paw Paw be relevant still?

Thank you very much.

Alex
Member

Ok friends, remember 2weeks on, 1 week off.

Alex
Member

A bit stunned here…..
In this article https://www.ncbi.nlm.nih.gov/pubmed/27356574/ “Maximal effect, an increase of LS by 34.5% (p < 0.05) was detected at a dose of 1.5 g/kg."
Can that be real or a typo?
I hardly believe that for a person that has 100kg for example that the daily dose should be 150g of DCA or more if that's just one of 3 doses. making it 450g of DCA daily.

Thank you Daniel for your ongoing work and help.

Cheers,
Alex

Ergin
Member
Hi Alex, Using it as a standalone therapy and with chemo or others are very different. I began DCA because Emad examined DCA helps chemo.It is exact. And our DR said very very good responce with brain ca.And not 150 gr:) In medicorcancer trials:They use DCA with thalidomide and only after 2 weeks later they see a responce or not.Because you have to wait for thalidomide to work(copper chelation).And there are not too many reports on that.Angiogenesis inhibitor is a must in any treatment. When i used it as a standalone therapy,i did not see any responce,opposite CA125 doubled. They… Read more »
Ergin
Member

Sorry not thalidomide in medicor trials,it was Tetrathiomolybdate (TM).

Alex
Member

I understand ergin, but the article linked by daniel is saying that the best dose is 1.5g/kg
https://www.ncbi.nlm.nih.gov/pubmed/27356574/

Jcancom
Member
Cancer compass is vetting my posts, so I thought I would resubmit here. Anyone have any ideas what the German investigators and or police are up to? “im Sande zu verlaufen” hmm.. Auf Englisch bitte! https://www.deutsche-apotheker-zeitung.de/news/artikel/2017/02/20/behoerden-streiten-um-ermittlungen-gegen-heilpraktiker “Derweil eskaliert ein Streit um die Ermittlungen: Polizei und Staatsanwaltschaft erstatten Anzeige gegeneinander und sind sich über die Tatvorwürfe uneins.” Unklar ist jedoch, ob aufgrund der instabilen Natur des nicht zugelassenen und umstrittenen Präparats 3-Bromopyruvat , das der Alternativmediziner verabreichte, ein Zusammenhang der Behandlung mit den Todesfällen überhaupt nachweisbar ist. However, the unstable nature of the unauthorized and controversial preparation 3-bromopyruvate administered by the… Read more »
Alex
Member

Gave mother the following this evening now.

Cabbage Brine – about 200ml
Omeprazol 20mg
Alfa Lipoic Acid 600mg
Metformin 500mg
Food
Aspirin 500mg
HCA 1000mg
30 min pause
Citric Acid 5g
DCA 500mg

We stopped the resveratrol tincture drops due to possible bad interaction between it and DCA as mentioned in this article.

Suggestions? Opinions? Please.

Thank you very much,
Alex

Alex
Member
Dear Daniel, I was reading about DCA lately, and have made a few possible connections. We have the 2 weeks on and 1 week off. Then there are statements from the scientists in canada saying that DCA inhibts it’s own metabolism and that it takes about 2 months to reach peak values in the boddy, or something like that if i remember correctly. There is also Emad saying he got better results with a specific brand. Then there is Ergin saying he saw no benefit from using DCA for his mother. What if all these are the effects of wrong… Read more »
Meech
Member

Re: dosage and scheduling.

I’ve been on 25mg/kg for about 12 months now without any time off. 7 days a week, continuously.

I am now attempting 31mg/kg (just over 2g daily) as of yesterday. If tolerated, I’ll move it up a bit again.

As for the dose cited in the article, rats are generally given a higher concentration of drugs IIRC due to metabolic differences.

Ergin
Member

Hi Alex,
There are 2 REAL cases about DCA.
http://medicorcancer.com/metastatic-ovarian-carcinoma-case-1/
http://medicorcancer.com/metastatic-ovarian-carcinoma-case-2/
I am the 3th real case you can only find on internet like these part by part.
Because i used it as a standalone therapy,without TM.
Kind Regards
Ergin

Ergin
Member

Another case ,she had hypothyrodism and pertioneal cancer just like my mother.
http://medicorcancer.com/metastatic-ovarian-cancer/

Ergin
Member

I didnt see any relieving of bowel obstruction but they saw.
As a result:my opinion,it is individual like other substances.

Alex
Member

Thank you ergin, i hope to talk to you again on skype, and please consider enemas for your mother’s bowel issues.

Alex
Member

Dear ergin
in the second case you presented it says this:
“the cancer came under control with DCA+TM treatment. The CA-125 increased slightly at the start of treatment as expected because of the 4-8 weeks it takes to create maximum copper deficiency. The CA-125 fluctuated slightly, but remained in the range of 39-55 for the next 6 months”

I wonder, did your mother take DCA for 4-8 weeks?

At the specified dose: (23mg/kg/day) on cycle of 2 weeks on / 1 week off.
If so, i ask, any results?

I hope you have good news,
Please take care,
Alex

Ergin
Member

Hi Alex,
Yes.she took 12 weeks DCA.
23mg/kg/day
5 days on,2 days off.
I was always thinking no responce,but we didnt know after stopping it,may be CA125 will be higher,who knows.
We are on chemo now with different combinations.So talking on probabilties from now on is nonsense unfortunately.
But still i feel that it was working with chemo in the beginnings.
Tomorrow i ll write on ovarian post.
Kind Regards
Ergin

Helga
Member

Hi Ergin & Alex,

I posted about LDN in another thread. I hope you can take a look and maybe benefit from it? The article claims 60% of cancer patients can benefit from LDN.

Kind regards,
Helga

Alex
Member
This cancer….. it’s like the terminator, always coming back. I keep thinking about how they killed it in the first movie, with pressure, and then i reminded myself about you and HBOT. THen i started to think about the human endurance to high pressures. Any max values. The more you read and think, the more you start to realize how random and lucky it must be to get back to normal health. This thing had millions if not billions of years to evolve, getting it to die is highly unlikely sadly. I’m happy to report that mother is feeling better… Read more »
Alex
Member

Also i am wondering about tetrathiomolybdate for copper depletion. Where to get that?

Alex
Member

Dear friends,
My mother is experiencing accelerated hair loss, i wonder if any of you have been seeing this with DCA or other treatments.
It may also be the case where something else is wrong.

Best wishes,
Alex

Emad
Member

My mother didn’t experience something like that with high doses of DCA , also her hair is growing despite taking Carboplatin and Gemzar + DCA

she only lost her hair due to Taxotere

Alex
Member

Thank you very much Emad

I hope you and your mother are doing better and that you have good news to share with us.

Best wishes,
Alex

Emad
Member

thank you Alex , I also wish the best for you 🙂 , we will see the results next week , and will share everything here like always

Jcancom
Member

Emad, have you thought of adding low dose 5-aza? On the compass there has been some excitement raised by this treatment possibility. It appears that many cancers could benefit.

Best wishes, Jcancom

Ergin
Member

High J,
Could you please give us some hints about it.

Jcancom
Member
Sure. On the compass thread we got started off with someone with testicular cancer. I read up on it and found PMID: 27936464 (click through it’s free!) . 5 nm? These demethylating agents look like they could be quite powerful especially in germ cell cancers. Yet, it appears that a broad range of cancers could benefit from low dose demethylators. PMID: 22586682 PMID: 22439938 The current generation drug 5-aza might not be a great test of the theory as it has a short half life. Almost hard to imagine that these drugs have sat on the shelf for almost 50… Read more »
Jcancom
Member
The idea here is that demethylating cancer cells can reveal all sorts of genes that would work against cancer. Typically there has been a fair amount of skepticism about targeting a single mutation in cancer treatment as cancer will find a way around it. Yet, what is interesting with demethylation is that there is a truly enormous amount that occurs with these drugs. There are probably multiple anti-cancer genes that become reactivated. However, it is still quite possible that resistance could still emerge through mutation in the DNMT1/3 genes. At the same time, 5-aza has a short half life, so… Read more »
Emad
Member

Hi J , hope you are fine

I never heard about 5-aza , where can I find it ?

I’m focusing now on DCA + procaine + high dose lansoprazol + CA + HCA , I run out of Salinomycin but wondering if the effect of base version is the same as the salt version , even when they have the very same side effects

also will be very happy to add 5-aza to my attention 🙂

hope I can know my more about it

Jcancom
Member
Emad, best wishes and congratulations on your sustained treatment success. Sorry for being confusing. This started for be by looking up PMID: 27936464. There is now a fair amount of interest and clinical research with these demethylators. It appears the demethylaiton effect could be broadly applicable to cancer (lung, breast …) Guadecitabine is in phase 3s and might be a few years out for approval. It seems that it could be an extremely powerful choice in refractory testicular cancer. 5-aza (5-aza deoxycytidine) has been used as a cancer medicine for decades at high doses and did not appear overly effective.… Read more »
Alex
Member

Emad,
bro, how is your protocol going? is it still the same as above?
How is your mom?
My mom is back on DCA, we got markers value increase with CA. 🙁 To be honest, not surprised but we gave it a shot.

Emad
Member
Hi dear Alex my mother feels better today , she had a hard time past week but now she feels better I shared the results in details in my post , still using DCA + chemo , but I will stop DCA once I receive 3-BP and Sal , I will stop DCA because of neuropathy I hope your mother is feeling fine , I saw your mother results the markers are growing slowly , I believe its a good chance to do extensive search and bring up the best strategies how about MG or thalidomide ? also, I have… Read more »
Alex
Member
Thank you for your reply Emad, i’m most delighted to hear she is feeling better and i hope it keeps on going towards the best. Would you please point me to your results post? Where did you order 3-bp from or Sal? What was the dose used of DCA and the method used to adminster it? Also, how much would you say is the optimum dosage for DCA from dcalab I will do my best to try to help my mother as much as i can. About MC or Thalidomide, i have more reading to do….. 😐 no port installed,… Read more »
Emad
Member
Dear Alex https://www.cancertreatmentsresearch.com/your-contribution-needed-on-breast-cancer-story-from-emad/#comment-4085 I ordered 3-BP and Sal from a western supplier , I am cautious to share the company name here , if you ask Ergin or Daniel or me in a private , they will mention it for you the oral dose we were using by DCA is 20mg/kg , 2 weeks on , 1 week off , or you can do it 5 days on , 2 days off for the IV , we were using 70mg/kg every third day (1 day on , 2 days off) its not different from what is mentioned in this post… Read more »
Wondering
Guest

also it makes sense to add the strongest natural demethylator : EGCG. works against ovarian and testicular cancer for sure.

Alex
Member

So i am wondering if and when doing the 2 weeks on and 1 week off scheme, would it make sense to use resveratrol in that one week?

Many Thanks!
Alex

Wondering
Guest

Alex, out of curiousity, how much dca is your mother taking? thanks.

Alex
Member

500mg X3 / 75kg
I was wondering if 500X4 would be better…..

Wondering
Guest
all, take care with DCA. i did not do a pause after two weeks and continued for another 2 days at 25mg even though i do know the recommendations. this was a mistake. I was very ill for a few hours: very high blood pressure, freezing, nausea, all kinds of strong aches in all my limbs, i almost went to a doctor but a rest helped. by now im fine, but i am off for 7 days and reduce back to 20mg. i take b1. this was a lot worse than any side effect on cisplatin, etoposide and bleomycine for… Read more »
Wondering
Guest

update re my main symptoms after 16 days dca use:
– back pain the same.
– i have much less fasciculations, its not so hard to quantify it

Alex
Member
Reporting in…. Stopping DCA for a week now, 2 weeks since received and started, 3X500mg – nothing worth mentioning about side effects or observed benefits. – Tests needed. Metformin “appears” to be VERY effective only when migranes exist. Citric Acid “seems” to be *NULL* ineffective even at 15g/d – My mother is a champion, she can take that like a pro and not even blink. 500mg aspirin + 500mg Metformin + Diet = Strong results (so it seems). 50mg Diclofenac seems to help somewhat but only if aspirin is removed (side effect risk) Quote marks used to specify that i… Read more »
Meech
Member

Hi Alex,

How’s your mom feeling? Any changes from before she started with all of these medications?

Thanks,
Meech

Alex
Member

we started around 6th of march,
DCA only for 2 weeks and stopped now as a brake,
She feels somewhat better…………………
The thing on her arm changes size and density from day to day….
I don’t know what to say sadly. Maybe it needs time or adjustments, or aditional elements to be added.
Shes been abusing bread, and didn’t feel good…. so my advice… stay away from it.

I wish this was a computer job, i’d fix her up in no time. Sadly… we are too complex and i have no previous experience.

Many thanks.
Alex

Meech
Member

Sometimes it’s tough to tell based on one tumour how the overall body is doing.

I’ve had palpable supraclavicular nodes since my diagnosis in 2014. Confirmed by CT scan as being outside the range of normal. They haven’t changed size at all apart from maybe 2mm or so in two years. However, other stuff has grown and shrunk in that time. I wouldn’t necessarily take the one module as an indictment of the bigger picture.

I’d give the “give up bread” advice to even those who aren’t fighting disease.

Meech
Member

“Module” should be “nodule”.

Alex
Member

Thank you very much Meech.
Good luck there.

Wondering
Guest

Alex, do i remember well that that thing was not biopsized yet? if this is the case I highly doubt its cancer based on your description.

Alex
Member

the original tumor was biopsied after surgery. there was no other medical intervention after.
thank you again for your reply

Wondering
Guest

OK, so there is no evidence that thing on her hand is cancer. maybe anothr biopsy would help to make you less nervous.

Alex
Member

Forgot to mention
Vitamin D3
Milk Thisle – Silimarin

Wondering
Guest

hi Alex. your mom is taking lots of useful stuff.
I know its hard above a given age but maybe some sort of keto light diet could help your mom.. At least low carb. I know that russian cuisine is far from it (just like most in europe). maybe focusing more on your brilliant soups and less on bread would also help?
If she feels better on it after a while thats probably a good sign. also its quite anti inflammatory. It might be difficult I know, especially for an elder men / women.

Alex
Member

Thank you very much Wondering, i will try to help her towards a low carb diet. Sounds like it may help her situation given the things observed,

Alex
Member

Well i’m very interested in Ketogenic Restricted Diet but its hard to find any certain info on it, for beginers.
Any links suggested?
Romanian cuisine 🙂 https://www.youtube.com/watch?v=8NiRDn0ci-Y + Many others.
My mother is a champion, she will do whatever it takes diet wise and not just that. I am very proud of her.
Do take care,
Best wishes
Alex

Wondering
Guest
hi Alex Yep, sorry, in the meantime i realised you are my “eastern neighbour “:)we have some common foods. http://www.ketogenic-diet-resource.com is a nice page. they dont deal with restricted version, but for this you can keep in mind following daily values : ” carbohydrates to 12 grams a day and protein is restricted to .8 to 1.2 grams (I use 1 gram) for every Kilogram of body weight. The rest is Fat” quite difficult! i managed it for one month – gave up on it a bit and now i do fasting + low carb. https://www.ruled.me/guide-keto-diet/ has some nice info… Read more »
Wondering
Guest

and all the studies use normal ketogenic diet..so restricted one must be even better for adjunct therapy.

Emad
Member

I have a bad news today , actually bad for me and my poor mother

tumor marker ca 15-3 raised from 322 to 607 in 5 weeks

Wondering
Guest

Hi emad, truly sorry to hear that. Pardon me, what cancer does she have and What is she taking altogether?

Wondering
Guest

DCA makes cancer cells to Cisplatin more sensitive;
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3834214/
anybody receiving cisplatin should consider to add dca in a safe dose before and during chemo in my opinion based on above.

reason:-
– cisplatin is not just damaging dna, its destruction depends on functional mitochondria. (cancers with functional mitochondria are more sensitive to it). I assume functional mito does not mean it is used too instead of glycolysis
– DCA promotes mitochondrial oxidation — ) cisplatin can kill more effectively

no impact on normal cells.

Frank Liu
Guest

Anticancer Effects of γ-Tocotrienol Are Associated with a Suppression in Aerobic Glycolysis.
https://www.jstage.jst.go.jp/article/bpb/38/9/38_b15-00306/_html

PaulF
Member

Frank

Where can one purchase y-Tocorienol?

Paul

Meech
Member

Found this:

“Tocotrienols are compounds naturally occurring at higher levels in select vegetable oils, including palm oil, rice bran oil wheat germ, barley, saw palmetto, anatto, and certain other types of seeds, nuts, grains, and the oils derived from them.”

Specifically, I found that palm oil is high in y-tocotrienol.

Frank Liu
Guest
Wondering
Guest
Guys, have been thinking about my reaction to DCA. There was one week where i clearly improved (after the second week of usage), for the rest of of time I felt more or less the same (maybe its a good thing though). After the second week i had something like a herxheimer reaction (it was scary) and right the day after I felt a lot better, less pain for instance. i reported this above. So i was checking what I did differently that week. All of this is speculative as i am marker negative currently but i have symptoms. Overall,… Read more »
Ergin
Member

Dear Wondering,
I highly recommend you to look at phlorizin patent.
I read it everyday when i am bored and when i feel hopeless.I read every word of it.
Phlorizin is not only used with hyperthermia.Also alone or with chemo etc..
If you can make fasting,you should look at this.
And they use lonidamine there,it works like 3BP ,we have to ask it to Daniel.

https://www.google.com/patents/US4840939

Wondering
Guest

hey Ergin,
thanks. The thing is that i can ‘t give anything intravenously.
Maybe i will need to learn but at this stage i am focusing on oral things. As i understood phlorizin is not helpful taken orally. If we could find a way to improve it (like pepperine works for curcumin: 20 times better consumption if you add black pepper or pepperine).
would love to add it… Any glycolisis inhibitor is a great help.
(empathise with you when you wrote you had a bad day because of the elections. I agree its disturbing!!).
cheers
W

Ergin
Member

Hi Wondering,
This is not ANY glyco inhibitor.
I am very sure that noone has read it from beginning to end because noone is talking about it..There is a great knowledge there.
Fasting,chemo,hyperthermia,cancer cell repairment,necrosis etc…AND A REAL CURE.
Also there are SGLT inhibitors oral use but works like phlorizin.We are always talking about CA and metformin.
I am alone in this section unfortunately.I need really conversation about it or i am going to think that i am stupid!!!!

Alex
Member

Anyone with feedback on DCA?

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