Curcumin: A Star in Cancer Treatment Field

Summary:

CurcuminWhen searching for some of the most effective anti cancer natural extracts accessible, low cost and non toxic, Curcumin will be one of the first we will come across. Curcumin is an extract from Tumernic a yellow-pigmented curry spice that is often used in Indian foods.

Curcumin relevance in cancer was so intensively researched so that today, a search on PubMed using “curcumin cancer” as search criteria will find 3329 published papers (Ref.),  This research covers most types of cancers and uncovers the potential of curcumin to influence a wide range of human genes, major pathways in cancer, cell membrane, etc. leading to important anti cancer properties (Ref.). With this, Curcumin alone may kill cancer cells while also being chemosensitizer and radiosensitizer for tumors and chemoprotector and radioprotector for normal organs (Ref.).

Beyond cancer, Curcumin has multiple therapeutic actions including anti-inflammatory, anti-microbial, hepatoprotective, cardioprotective, thrombosuppressive, anti-arthritic, anti psoriasis. In addition, traditional Indian medicine has considered curcumin a drug effective for various respiratory conditions (asthma, bronchial hyperactivity, and allergy) as well as for other disorders including anorexia, coryza, cough, and sinusitis. (Ref.)

Curcumin mechanismsDue to the huge range of anti cancer mechanism connected to Curcumin, I am not going to start discussing them as it will probably take forever. Instead, I will focus on its application and to highlight its action I will just use pictures such as the one below from the enclosed reference (Ref.). This clearly indicates a wide range of activity of Curcumin.

Nevertheless, even this picture it only covers a little from what has been so far experimentally demonstrated that Curcumin can do. When reading the literature, it feels like Curcumin can address ANY problem, from bone disorders (Ref.) to brain challenges (Ref.). Due to this fact, I would consider Curcumin as a part of any anti cancer treatment protocol.

Curcumin downregulates cellular protein synthesis, and induces autophagy, lysosomal activation and increased ROS production, thus leading to cell death – mTOR inhibitor (ref.)

Curcumin inhibits glyoxalase 1: a possible link to its anti-inflammatory and anti-tumor activity. http://www.ncbi.nlm.nih.gov/pubmed/18946510 This may be one of the very relevant mechanism of Curcumin and due to thsi property it may make sense to combine Curcumine with most pro-oxidant treatment approaches including Chemo, 3BP or Methylglyoxal.

Personal experience:

Next to the oral version, we have had Curcumin IV from time to time, for nearly two years, and we have a very positive feeling about it. During and after the IV we typically experience pain at the tumor site. Tremour has also been reported to take place for about 30min after the IV. This is probably present in about 50% of patients using Curcumin IV from what I understand. It is not yet clear what is the origin of the tremor but it is believed to be connected to the rise of uric acid as a result of the tumor lysis effect.

Many German doctors are “in love” with Curcumin IV.

Toxicity:

“The first phase I clinical trial to test the toxicity, pharmacokinetics, and biological effective dose of curcumin was carried out by Cheng et al., in 2001 [292]. Twenty-five patients who had either one of the following pre-malignant high cancer risk conditions were included: urinary bladder cancer, arsenic Bowen’s disease of skin, uterine cervical intraepithelial neoplasm (CIN), oral leukoplakia, and intestinal metaplasia of the stomach. An escalating oral dose of 500, 1000, 2000, 4000, 8000, and 12,000 mg was tried and treatment-related toxicity was not observed up to 8000 mg/day. Higher doses were found to be unacceptable to the patients, primarily due to bulky volume of the drug. Peak serum curcumin concentration was reached 1–2 h after intake, while it was undetectable in urine.” Ref.

Bio availability & Pharmacokinetics:

It has been found that 10 mg/kg of curcumin given intravenous in rats gave a maximum serum curcumin level of 0.36 µg/mL, whereas a 50-fold higher curcumin dose administered orally gave only 0.06±0.01 µg/mL maximum serum level in rat. (Ref.)

Indeed, it is well known that the bio-availability of orally administrated Curcumin is very low. However, the clinical trials discussed below indicate that 2g to 12g of Curcumin administrated orally to humans can lead to anti cancer effects.

Scientists are currently investigating various ways to increase Curcumin bio availability. One of the most simple and effective ways to increase the bio availability in humans is by co administration with another plant extract, i.e. piperine: “In humans, curcumin bioavailability was increased by 2,000% at 45 minutes after co-administering curcumin orally with piperine” (Ref.)

Once administrated, Curcumin is absorbed differently in Blood, Liver, Brain, Kidney, and Other Organs http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3918523/figure/F3/

Clinical trials on humans:

Summary of clinical trials with curcumin in various cancers: http://www.mdpi.com/1420-3049/20/2/2728/htm

Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer: Radiologically stable disease was demonstrated in five patients for 2-4 months of treatment at doses between 440 and 2200 mg/day.

Combination treatment with curcumin and quercetin of adenomas in familial adenomatous polyposis: The combination of curcumin and quercetin appears to reduce the number and size of ileal and rectal adenomas in patients with FAP without appreciable toxicity. Randomized controlled trials are needed to validate these findings.

Phase II trial of curcumin in patients with advanced pancreatic cancer.: Two patients showed clinical biological activity. One had ongoing stable disease for >18 months; interestingly, one additional patient had a brief, but marked, tumor regression (73%) accompanied by significant increases (4- to 35-fold) in serum cytokine levels (IL-6, IL-8, IL-10, and IL-1 receptor antagonists). No toxicities were observed.

Administration and Dose:

A very helpful blog to read with a good amount of info on the use of oral and topical curcumin is here http://margaret.healthblogs.org

Oral administration: 30 to 60 min before food with a glass of water, 2 to 3x/day, 1-4g each time (leading to a total of 3 to 12g/day). Adding some oil (e.g. olive oil capsules and/or Nigella Dativa and/or fish oil) will help the absorption. If it doesn’t have already Piperine inside than add a small amount of black paper powder or Piperine capsule (like this one).

Oral administration has been shown to provide some benefit, but absorption and distribution kinetics do not always allow maximal benefit.

Topical administration:

Option 1:  The origin of this formulation is coming from a recent article sating the following: “We have developed a curcumin-based vaginal cream, which effectively eradicates HPV(+)cancer cells and does not affect non-cancerous tissue. Our preclinical data support a novel approach for thetreatment of cervical HPV infection” Ref The formulation used was: “Intravaginal formulation containing 2%, 5%, 10% and 20% (w/w) curcumin were prepared by mixing curcumin powder with a com-mercially available topical oil-in-water cream base called Vanicream (Pharmaceutical Specialties, Inc., Rochester, MN). Our tests showed that 5 g of Vacurin occupied a volumeof 5 ml. Therefore, in the rest of this report, we have expressed the concentrations of curcumin in Vacurin as 20% (w/v). The two compo-nents were thoroughly mixed using a spatula…”

Option 2: Here is another formulation from a different article: “Curcumin C3 Complex (>98% pure) was obtained from Sabinsa Corp. In vivo studies were conducted with curcumin (15 mg) suspended in a vanishing cream paste (15 mg/100 μL cream) for topical administration provided by our study compounding pharmacist (DB).” Ref.

IV administration: 150-400mg/m2 in 250 to 1000ml NaCl 0,9% during one to two hours, 2-4x/week, administrated via either a central or peripheral line.

Notes:

  • there are various forms of Curcumin for IV. If it contains Kolliphor than the IV has to be administrated in PVC free IV set or using a 0.2 um inline filter system to avoid the typical allergic reaction. In case Kolliphor is present, some clinics are administrating prior to the first IV the following mixture to avoid allergy: in 100 ml NaCl 0,9% add Fenistil 8 mg + Ranitidin 50mg + Dexamethason 8mg + Ondansetron 8mg
  • some clinics in Germany are mixing Curcumin with DMSO (2 to 10ml) in the same NaCl bottle for increased effectivness. When that is done, the Curcumin dose is usually reduced to half of that administarted withouth DMSO.
  • No other additives should be mixed in the IV bag with the curcumin and carrier solution
  • Some are suggesting that oxidative treatments including IV Ascorbate over 20 grams should be separate by 24 hours

According to the following patent Curcumin IV can also be relatively easily prepared :

  •  http://www.google.com/patents/DE102012219219A1?cl=en in the following way:
    • Curcumin 150 mg are dissolved in 4 ml of absolute ethanol with stirring and heating to about 70 ° C. After 15 minutes, a clear dark yellow solution was formed.
    • In this solution, 34 mg of citric acid are dissolved in anhydrous form.
    • 25.88 g Kolliphor ELP are mixed with 12.37 g of absolute ethanol. With the mixture thus prepared, the Curcuminlösung prepared above is filled up to 10 ml.
    • The resulting solution is sterile filtered and autoclaved at 121 ° C.
    • This gives a storable pharmaceutical formulation containing curcumin in dissolved form.

Note: my idea was to use DMSO and not ethanol as suggested in the patent. This is because in order to get Curcumin soluble in ethanol there is a need to increase temperature to 75C (as suggested by the patent) while if we chose for the DMSO mixture, that  can be performed at room temperature. Note: I never prepared – is just an idea.

Other formulation ideas from Dr. Mercola:

  • Make a microemulsion using raw curcumin powder. Combine one tablespoon of the powder with 1-2 egg yolks and a teaspoon or two of melted coconut oil. Use a high speed hand blender to emulsify it. Keep in mind that curcumin is a very potent yellow pigment that can permanently discolor surfaces, so take precautions to avoid “yellow kitchen syndrome.”
  • Boil the curcumin powder. Another strategy that can help increase absorption is to put one tablespoon of the curcumin powder into a quart of boiling water. It must be boiling when you add the powder as it will not work as well if you first put it in room temperature water and then heat the water and curcumin. After boiling it for 10 minutes you will have created a 12 percent solution that you can drink once cooled. It will have a woody taste. The curcumin will gradually fall out of solution however. In about six hours it will be down to a six percent solution, so it’s best to drink the water within four hours.

Source:

Oral: There are various sources each with the claim that it is the most bio-available. Meriva  seems to be one of the best source. We are using this one: http://www.iherb.com/Doctor-s-Best-Best-Curcumin-C3-Complex-with-BioPerine-1000-mg-120-Tablets/12137 Also, I like Curcucell: https://www.essential-foods.de/catalog/product_info.php?products_id=626

We should make sure we use Curcumin (i.e. the extract from Turmeric) and not the Turmeric powder since Turmeric powder contains about 3.14% Curcumin only,  according to the following reference http://www.ncbi.nlm.nih.gov/pubmed/17044766

IV: there are several German pharmacies providing the IV form:

Other references:

Curcumin Sensitizes Silymarin to Exert Synergistic Anticancer Activity in Colon Cancer Cells http://www.jcancer.org/v07p1250.htm

We studied combinatorial interactions of two phytochemicals, curcumin and silymarin, in their action against cancer cell proliferation. Curcumin is the major component of the spice turmeric. Silymarin is a bioactive component of milk thistle used as a protective supplement against liver disease. We studied antiproliferative effects of curcumin alone, silymarin alone and combinations of curcumin and silymarin using colon cancer cell lines (DLD-1, HCT116, LoVo). Curcumin inhibited colon cancer cell proliferation in a concentration-dependent manner, whereas silymarin showed significant inhibition only at the highest concentrations assessed. We found synergistic effects when colon cancer cells were treated with curcumin and silymarin together. The combination treatment led to inhibition of colon cancer cell proliferation and increased apoptosis compared to single compound treated cells. Combination treated cells exhibited marked cell rounding and membrane blebbing of apoptotic cells. Curcumin treated cells showed 3-fold more caspase3/7 activity whereas combination treated cells showed 5-fold more activity compared to control and silymarin treated cells. When DLD-1 cells were pre-exposed to curcumin, followed by treatment with silymarin, the cells underwent a high amount of cell death. The pre-exposure studies indicated curcumin sensitization of silymarin effect. Our results indicate that combinatorial treatments using phytochemicals are effective against colorectal cancer.

Disclaimer:

This site is not designed to and does not provide medical advice, professional diagnosis, opinion, treatment or services to you or to any other individual. Through this site and linkages to other sites, I provide general information for educational purposes only. The information provided in this site, or through linkages to other sites, is not a substitute for medical or professional care, and you should not use the information in place of a visit, call consultation or the advice of your physician or other healthcare provider. I am not liable or responsible for any advice, course of treatment, diagnosis or any other information, services or product you obtain through this site. This is just my own personal opinion regarding what we have learned on this road.

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63 thoughts on “Curcumin: A Star in Cancer Treatment Field

  1. Thank you. I was actually searching for that reference on the liver tumor that was strongly reduced following 8g/day Curcumin. I have seen it two years ago but could not find it anymore 🙂

    Regarding your question, it is not that straightforward. There are many studies indicating the synergy of Curcumin with chemo. However, on the other hand we “burned” ourselves a few months ago by combining antioxidants with pro-oxidants …. i.e. cancel out the pro oxidant effect. So, I would use Curcumin only if chemo alone seems not to be effective. Otherwise, I would stop the administration a few days before and after chemo. This is what I would do but I know conventional doctors in Germany who are actually combining chemo and radiation with Curcumin (and others) … while claiming improved results.

    1. The anti-oxidant and pro-oxidant roles of Curcumin depend on dose, also the effects are different for normal and cancer cells.
      Usually Curcumin enhances the oxidative stress induces by chemo in cancer cells and may protect some types of normal cells.

      1. Hi Ovidiu, this is why I do not like to combine during the same day: i.e. it can act as an antioxidant. And when making the serious effort to take chemo it doesn’t make sense to add risks unless we are sure the chemo is not effective. I specifically developed this view during the last months when we saw on CT how antioxidants can save the cancer cells under pro oxidant stress. Using it a few days after or before chemo should be fine. However, Curcumin alone can be effective too.

    1. I see Santa and Sigma have various forms. I wouldn’t know which to order. Do you have a CAS# from your source? If I had that I would still face the problem I’m experiencing with Sal, finding a source of small quantities of anhydrous ethanol 200 proof 🙂

      I purchase whatever the current cheapest Longvida product through Amazon. many times it’s Curcubrain, 400mg tabs. I’ve been able to find it for less elsewhere but the sources tend to dry up. Amazon gets it to me tomorrow so I default to them.

        1. I have a naturopath friend. I’ll see if she can source “prepared” curcumin IV solution for me.

          I can find the ethanol only in cases (>5 gal.) Also, while the basic cost for that is less than $100, excise taxes, hazardous shipping fees, shipping fees etc. add on over $200. Costs and laws may be different on your side of the world.

            1. I finally located a large supplier of pure 200p non-denatured alcohol (who only stocked 5 gallon quantities) into ordering 100ml from SA and then shipping to me. Final cost was $125 which is still very high but that adventure is behind me. Procuring Sal was easy but all the other parts took weeks!

            1. “Pure turmeric powder had the highest curcumin concentration, averaging 3.14% by weight”, according to the following reference http://www.ncbi.nlm.nih.gov/pubmed/17044766
              I would guess that a spoon of turmeric is about 5g in total (maybe even less since the powder is relatively light). If only 3.14% of that is Curcumin, it means you take every day about 150mg Curcumin. This is 50x less compared to the average used in the clinical trials and compared to what cancer patients are using daily, i.e. about 8-9g/day.

  2. My husband will start tomorrow infusions with vit c, curcumine and quercitine and also taurolidine. Should there be some break between vit c and curcumine / quercitine?

    Thank you for your answer.

    1. Hi Ann, I am sorry to hear about your husband (Freddy?). May I know at what clinic you are going to have the treatment? We are using Quercetin first, 5 min break with saline, and after that Curcumin. Taurolidine sounds good as well. Please note that with a prescription from German doctor you may be able to get Taurolidine from your pharmacy in Belgium. I live in the Netherlands and here is possible too, with no cost – covered by the insurance. So you will only pay the administration in Germany.

  3. Hi Daniel, how you know my husband name if I can ask? Did we possibly meet?

    We are having treatment with dr kilarski. We could have taurolidine here from ogarnąć but that charge us 70 euro per bottle. And we need three per week.

    I have some small dubt about iv vit c together with curcumine as first acts pro -oxidatief and. C urcumine and quercitine as antioxidant. Have you some experience here. Can i reach you via email?

    1. Dear Ann, I would not be worried about Vit C and Quercetin. In IV form Quercetin can act as pro-oxidant. Curcumin is questionable so maybe use the other day. However, I would not mix with strong antioxidants such as Alpha Lipoic Acid IV, not even after 24 hours.

      We did not met before but I am a curious researcher 🙂 You can contact me at [email protected]

  4. Hi Daniel,

    There is a compounding pharmacy in USA called Park pharmacy or Imprimis Pharmacy (the same), they have curcumin IV 10mg/ml, i am a customer there, but sometimes they are out of stock, do you know if there are other pharmacies around the world that can provide curcumin IV?

    Thank you

    1. Hi Mireya,

      As I understand from your email, you are paying 39 USD per bottle 10mg/ml 10ml vial and in Harbor Mexico 40USD per bottle 5mg/ml 10ml vial.

      The German sources are:

      http://apotheke-koenigstein.de/ – containing Kolliphor
      http://cfb-eigenherstellung.de/ – not containing Kolliphor?
      http://www.curafaktur.de/ – not containing Kolliphor (this is the one we are using and is easier to administrate since it is not containing Kolliphor but this lab has a different model – the doctor is going to the lab and prepares the IV himself)

      Can you please let me know if you are using it and if you see any sign of effectiveness after using Imprimis source?

  5. Hi Daniel,

    Yes, we are using curcumin from both pharmacies and it is working very good. We have seen improvement after administration of it, 3 times a week per 3 weeks.

    Best regards

    1. Thanks Mireya. This can get very expensive since 100mg cost 40 USD. The material cost would be from 100 USD up to 1200 USD for one IV. Are there other IVs you tried from that pharmacy?

  6. Emad, in order to have a response from them you would need:
    1. to be a MD or pharmacist
    2. to trave to Germany in order to prepare your own IVs in their lab with their material
    That is their business model.

    As a private person you would need to order from the other two I mentioned. I would order from CFB since their product is easier to work with as it doesn’t have Kolliphor inside.

  7. Hi Daniel,

    Yes it is very expensive to administer up to 3gr.

    We started using high dosages of Curcumin 3gr IVs in 100mg vials, it means we use 30 vials in one IV for 4 hours. But i noticed the patients are reporting liver and lipids saturated. i checked the vials of imprimis and the exipients are vitamin E, glycerin and castor oil, it may be causing that.

    What dosages do you recommend as highest.

    1. Hi Mireya,

      I usually like to stay away from high doses of castor oil, and the quantity in so many vials may be very high. If I wold want to still use such high doses, I would use Curcumin that doesn’t contain castor oil such as this one http://cfb-eigenherstellung.de/. But I also suggest to try this source which has less curcumin but other curcuminoids as well as it is whole plant extract http://www.curafaktur.de/ The dose depends on the source and I never heard about using so high doses as you used. 🙂
      The highest recommended dose I came across was 450-500mg/m2.

  8. Hello Daniel

    we are going for Methylglyoxal for sure

    but due to our limited financial resource , we have only 2 options between those 2 to add with MG :

    1- Salinomycin : 2 IVs per month (1 IV = 0.2mg/kg)

    2- Curcumin : 400mg every week (for a patient weigh 75kg)

    (( we know that Salinomycin is stronger than Curcumin , but with these limited doses , I don’t know at all which one is better to spend our hard earned money on it ))

    I can’t ask you which one you recommend for me , but maybe I can ask you which one you will prefer for your self or a family member ^^

  9. My Mom is diagnosed with 3c stage ovarian Cancer and she is getting her treatment in http://www.icamwellcare.com/ (Dr Irfana Akhtar ) (India Bangalore )

    We need Curcumin Intravenous (extract from Turmeric) and It not available in India but there is a pharmacy in Ontario (York Downs Pharmacy) who is having this . but they want Canadain Doctor precipitation.

    So I need a help from a local Doctor who can talk to Indian Doctor and get that medicine on their behalf which I can take with me to India .

    So I want to Check If any can help me getting this medicine on behalf of Indian Doctor .

    Doctor from India can fulfil all requirements If anyone canget me this from any country to Order This Medicine on her Behalf

    I don’t have Much Time to obtain this medicine before I leave for India

    http://www.icamwellcare.com/ (Dr Irfana Akhtar ) (India Bangalore )
    +91 99002 66719

  10. Hi Daniel,
    How are you?I hope you are not ill and everything is fine.
    Take care of yourself and drink some collodial silver:)
    I tried 3 days ago for sinus infection.The disease gone.
    Also we begin collodial silver for mother today.
    Why i write here?
    I have found that curcumin is also a good angiogenesis inhibitor.
    And here is an article about difference between pure curcumin and the extracted by ethanol type.

    http://www.tandfonline.com/doi/abs/10.1080/13880200802215826

    Kind Regards
    Ergin

    1. Hi Ergin,

      Thank you for your msg. This beginning of the year was full of events including traveling and various events that required my attention. I expect this will end at the end of this week so that in the weekend I can answer some your remarks on the Foundation and the question from Carl on the Foundation.
      Very nice article. Thanks for the link. I totally agree with the conclusion based on what I’ve seen: i.e. the ethanol (and water) extract is more active compared to pure curcumin. That was my conclusion as well after seeing the effects of the IV forms of the two. In Germany, there is a lab that is producing ethanol/water extract for IV but only doctors can access and they need to go there to “produce it” themselves. But I think, it is so easy to produce that you could easily build up a production site in Turkey.

      Kind regards,
      Daniel

        1. Hi Ergin,

          Hormones are actually synthesized from cholesterol. One of the primary functions of nutritional lipids is actually hormone synthesis. Lipids do have a large influence in hormones and steroids (of which cholesterol is one) within the body.

          So you’re right. There’s a huge relationship between cholesterol and hormones.

            1. When I was diagnosed, my parents were in the drivers seat (I was 23 at diagnosis so quite young), and they had heard from friends that a vegan diet was best. So lost about 11-13lbs on that diet in the 6 months I was on it. Went from 163lbs to 149-152lbs. But I was eating fairly high sugar. Vegetable + fruit juices (juiced at home), potatoes, rice, breads (though they were kamut and spelt flour – not sure if that makes a difference). All in all, I wouldn’t call it healthy.

              After my major surgery, I went from 148lbs the night prior to surgery to 138lbs the day after surgery. Part of this was due to the physical amount of tissue removed (9-10 hour surgery; surgeon said they removed around 6lbs of tissue). And part was due to low amount of food post-operatively.

              I started eating whatever I wanted, including fast food and went back up to 148lbs. Then started keto and dropped to 138lbs again in about two weeks (2 days I fasted on barely any food to kick start ketosis).

              I dropped to about 133lbs each time I went on TACE, and went back up to 138lbs in the month following, then would drop back again after TACE, etc.

              I have now managed to climb back up to 146-148lbs using my own Keto weight gain protocol. I do eat an okay amount of meat and eggs, some cheese. But keep my protein to about 1g/kg, give or take 10-15g per day.

                1. Thank you very much for that elaborate reply.
                  I’m getting a feeling that all this could be solved with optimized nutrition for the person/case upon blood tests.
                  Maybe i am saying stupid things but i am getting a feeling that if the body would “steal” the resources from the cancer due to it’s requirements for them, than maybe we could deal with it.
                  What if my mother’s body would actually use that nutrition before the cancer does eh?
                  If i am closer to the truth here than it must mean that to heal from cancer we would need to accelerate metabolism of the normal cells.
                  Since you are more informed in these things than me, i wonder what you think about all this.
                  Thank you
                  Alex

                  1. The issue is that even when our body uses the nutrition prior to the cancer cell, it can still convert the macronutrients (in this case lipids or proteins), through normal bodily metabolism, into products that the cancer can use for its own devices.

                    For example, if the body readily uses fatty acids prior to the cancer being able to use them, the net result from the normal metabolism of fatty acids by normal cells will still partially be cholesterol, which the cancer cell can use.

                    It’s by this notion that I think it needs to be combined with other methods.

                    For example, statins have shown a lot of promise in cancer treatment (particularly lipophilic as opposed to hydrophilic statins from what I’ve read). These can lower cholesterol levels, but also work in other ways against cancer cells.

                    So I’m guessing combining a statin with the Keto diet would be more beneficial than just the diet alone.

                    I’m of course not 100% sure of this but it would make sense to me.

                  2. Hi Alex,

                    There are people and treatments that use that kind of logic. I just found an article where people were fasting before/after chemo: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2815756/
                    “Here we describe 10 cases in which patients diagnosed with a variety of malignancies had voluntarily fasted prior to (48-140 hours) and/or following (5-56 hours) chemotherapy. None of these patients, who received an average of 4 cycles of various chemotherapy drugs in combination with fasting, reported significant side effects caused by the fasting itself other than hunger and lightheadedness. Chemotherapy associated toxicity was graded according to the Common Terminology Criteria for Adverse Events (CTCAE) of the National Cancer Institute (NCI). The six patients who underwent chemotherapy with or without fasting reported a reduction in fatigue, weakness, and gastrointestinal side effects while fasting. In those patients whose cancer progression could be assessed, fasting did not prevent the chemotherapy-induced reduction of tumor volume or tumor markers. Although the 10 cases presented here suggest that fasting in combination with chemotherapy is feasible, safe, and has the potential to ameliorate side effects caused by chemotherapies, they are not meant to establish practice guidelines for patients undergoing chemotherapy.”

                    Problem is, most cancer patients have lost already a lot of weight so cannot afford the “luxury” of making their cancer cells starve.

                    I also read on a forum that there is a popular fasting method where you mustn’t eat any solid food for 42 days or so. However, the outcome was not particularly good for a woman with metastatic (to the bones) breast cancer. It is a dangerous gambling! It didn’t help her metastases, I remember.

                    1. Thank you very much dear Helga for your priceless replies.
                      Perhaps a combination of as many tricks as possible would lead to permanent remission, so i hope.
                      Reduction of glucose, colesterol and other strategies, when combined would lead to a positive result

                      I hope you’re doing well,
                      Alex

        2. Hi Ergin,

          It might, it seems: https://community.breastcancer.org/forum/79/topics/827489

          Joined: Aug 2014
          Posts: 3,058
          Hopeful82014 wrote:

          Many sites suggest turmeric (or curcumin) may have anti-inflammatory and anti-cancer properties, among other benefits. However, WebMD states:

          “Hormone-sensitive condition such as breast cancer, uterine cancer, ovarian cancer, endometriosis, or uterine fibroids: Turmeric might act like estrogen. If you have any condition that might be made worse by exposure to estrogen, don’t use turmeric.” However, I know several MDs who use it themselves….

          1. Dear Helga,
            Thats why i am afraiding to use curcumin,quercetin,artemisinin etc.
            Is the ovarian cancer totally different than others???
            In all treatments i see some results like this.
            Kind Regards
            Ergin

  11. Dear Alex (no link at the bottom of your msg),

    I have been ok, yesterday scored 156 in Dart in one round (2 triple 20-s and one triple 12) 🙂 We took a photo for the record. I recommend it to everyone, it is very uplifting and great fun. Plus, not too taxing on the body, so even most cancer patients can do it. I think it produces quite a bit of endorphin, at least we always leave in a much better mood than we were in at arrival.

    I am making my own fermented wheatgerm now. We found dry wheatgerm in our local shop. I add some baker’s yeast and water and put it on the radiator (dish put in a plastic container so not too much direct heat reaches the dish, not too hot) for a night. When the taste turns sour (from sweet) and bubbly (from the fermentation), it is ready to consume. I put it in the fridge when it is ready. And, yes, add some citric acid to stop the fermentation! 🙂 (with a wink to Dr. Alberto). It does work, try it!

    How have you been and your mom? Hope she is ok.
    Best wishes and Happy Easter,
    Helga

    1. Lovely 🙂
      My mother hasn’t been ok today, high blood pressure, pain and stabbing in the back and right breast, despite treatment.
      The bump on her arm fluctuates in size from day to day, today it’s been smaller.
      Managed to get her blood pressure lowered with in house tricks, hot water for the feet, lemon squeezed in mineral water and calming down, rest, they all helped.
      She’s been feeling great till today so she kinda abused it by doing work in the house and around it.
      If citric acid does inhibit fermentation it may reach the tumor in insufficient quantity, so i think.
      I’m thinking it may very much use a transporter such as DMSO to be applied to the skin, while also drinking it.
      Very glad you’re enjoying it there,
      I don’t know where you’re from but would love to get out and have a drink with you and everyone here.
      Most likely, i need a bottle of wine for me and a vacation far away from all these problems.
      Thankfully, there’s hope!

      Happy easter
      Take, care
      Alex

  12. CurQfen ® is a ‘new generation’ bioavailable curcumin, capable of providing ‘free’ curcuminoids into plasma and further into organ tissues with improved BLOOD-BRAIN-BARRIER permeability (Journal of Functional Foods, 2015, 14, 215).
    Various animal and human studies have also demonstrated ‘free’ curcuminoids bioavailability (45.5-fold), pharmacokinetics, relative distribution of ‘free’ curcuminoids (>70%) (Journal of Functional Foods, 2016, 22, 578).
    http://akay-group.com/spiceuticals_products/

    Enhanced bioavailability and relative distribution of free (unconjugated) curcuminoids following the oral administration of a food-grade formulation with fenugreek dietary fibre: A randomised double-blind crossover study.
    http://www.sciencedirect.com/science/article/pii/S1756464616000426

    Swanson Superior Herbs Controlled Release CurQfen Curcumin/Fenugreek Complex.
    https://www.swansonvitamins.com/swanson-superior-herbs-controlled-release-curqfen-60-veg-caps

  13. I have very interesting findings about curcumin.
    It makes intracellular glutathione levels very high like a powerful antioxidant.
    But it is synergetic with chemo.

  14. Hello, is there any knowledge about fresh curcuma an it`s bio availability and application?
    I got a product written: each cps contains 340mg extract from curcuma longa with at least 95% curcuminoides, 50mg Cholin and 5mg piperine. Is that, what is recommended orally?
    Thank you. Katja

    1. Hi Katja,

      Bio availability of curcumin is low, below 10% usually. Indeed taken with piperine and fat is expected to help increase the absorption. The dose expect to lead to high enough plasma level is in the range of several grams/day. This could be a good option https://nl.iherb.com/pr/doctor-s-best-high-absorption-curcumin-with-c3-complex-and-bioperine-1-000-mg-120-tablets/12137
      Liposomal Curcumin may also be an option to try.

      Kind regards,
      Daniel

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