Dear Friends,

The message below was written during September 2019:

Short intro:

I am a nearly 40 years old man, PhD in physics and I live in the Netherlands. Due to reasons discussed here, my research focus is on understanding cancer related mechanism, drugs and supplements to modulate that, and how those can be applied alone or in combination with conventional treatments to increase the chance of a successful outcome. Nearly every day I work on improving my knowledge by researching the conventional and alternative space and communicating with scientists, medical doctors and patients from around the world. So far I spent thousands of hours in this space and I intend to continue that. My focus is on advanced cancers.

My goal is to help cancer patients improve and extend their life, to the best of my knowledge. If your goal is the same and would like to contact me regarding that please let me know. I am always glad to consider potential collaborations on this line.

With this Blog, I intend to bring actionable knowledge to the visitors of this website. What is unique about this website is that nearly every treatment discussed

  • is strongly backed up by scientific references, nearly every statement (not just beliefs)
  • includes references to successful applications in humans published in scientific journals (not only anecdotes)
  • includes information on how to access the treatment and how to apply it (not just a story but actionable information)

Next to this, there is a great community of cancer patients and caregivers sharing their knowledge and views. Sometimes scientists are joining the discussion and sometimes even medical doctors (with the enclosed Disclaimer).

And all it’s free!

As you will see from this website, I believe that there are multiple ways to fight cancer. Some may include conventional treatments and others may include alternative treatments. I do not have any bias towards any of these treatments whether they are synthetic or natural, alternative or conventional, oral or intravenous, anti-oxidants or pro-oxidants, and so on … What is important is that there is enough evidence and that the various substances are applied in a coherent manner, so that they work together and not against each other, so that we can achieve the goal to improve and extend life.

Communicating with me by e-mail and Skype:

I often respond online. However, if you like to contact me by e-mail regarding questions related to cancer treatments, for you or for a loved one, please consider the following:
.
For the past 5 years, I helped everyone who asked my help, and I always did that for free. I even stopped my normal job (senior management in a top multi-national) in order to help others while being unemployed and running on own savings. I spent most of my days researching and answering e-mails and calls, while I could chose to spend it like most of the people do, with friends, family and a normal job. I do that with pleasure and passion as I know that helps people. However, working for free is not sustainable.

I hoped donations would help, but the reality is that even if this website has more than 300.000 visitors/year, and I answer hundreds of questions/year, the donations I receive every year are just enough to cover the costs related to the maintenance of this website and addressing the technical challenges that often come with it. This made me realised that while I help people in need, I can not rely on receiving help back. This is probably normal in this world when most content over the internet is free. Therefore, next to helping you by creating and sharing free and actionable content, and answering your questions, I need to find a way to do this in a financially sustainable way. Otherwise, my savings will be gone in less than a year (I am writing this during September 2019) and will have to move back to a normal job and slow down or even stop my actions in trying to help others.

With the hope and goal to insure financial sustainability and support me in helping much more cancer patients, I intend to have a food supplement company started in a few months (I discussed that earlier here). In order to have time for this, but also be able to continue adding content on this website, I will reduce my communication with cancer patients during the next months.

Therefore, if you intend to contact me:

  • please first use the search function on this website to see if that point was already addressed (also check the Forum)
  • please consider asking your question on the website (at the bottom of any post that I wrote) or you can create your own topic on the Forum – in this way other contributors on this website will also be able to respond, and the online discussion will help reduce the chance receiving this question again

If your question is short but you can not ask it on the website due to personal reasons, you can send me an e-mail and I will do my best to reply as soon as I can.

If your question is more extensive and requires intensive guidance, it is best that you consider a professional consultant in oncology such as listed on this page https://www.cancertreatmentsresearch.com/a-list-of-some-of-the-worlds-best-integrative-oncology-consultants/

Thank you for your understanding.
.
Kind regards,
Daniel
.
My primary e-mail address is: cancertreatmentsresearch (at) gmail.com



Please read the following Disclaimer before contacting me https://www.cancertreatmentsresearch.com/?p=1735 as it applies to any further discussion. If you contact me, it implies that you read, understood and agree with the Discalimer.

91 thoughts on “Contact

  1. Hi Daniel,

    Hope all is well. Do you by any chance have details of any patients who have used or have been using 3-BP in India. My father has been diagnosed with Oral Cancer SCC on tongue last year and it has spread to the lymph nodes in the neck now. The doctors have suggested Radiation therapy along with Chemo. I’ve read about 3-BP on couple of forums and some research papers documenting the usage of 3-BP in humans and I am excited about exploring it as alternate treatment.
    It would be great if you can share any details that you might have about 3-BP patients, so I can contact them about the treatment options.

    Thanks,
    Sravanth

  2. Just wondering if you have any recommendations or protocols for Neuroblastoma a family friend has been given under a year to live and the doctors say nothing more they can do to help.

    1. Dear Darren, I am sorry to hear that. You can use the serch option on this page to serach for Neuroblastoma related subjects and you will find a few specific points. However, many of the potential treatments discussed here are not specific so they may be relevant even if not specifically discuses in the context of Neuroblasoma. Next to that you may want to have a look at these posts:
      https://www.cancertreatmentsresearch.com/?p=948
      – POH: https://www.cancertreatmentsresearch.com/?p=602
      – Dendritic cells and NDV: https://www.cancertreatmentsresearch.com/?p=643
      – ECCT: https://www.cancertreatmentsresearch.com/?p=865
      – Scorpion Venom https://www.cancertreatmentsresearch.com/?p=1037
      – Salinomycin http://www.fasebj.org/content/28/1_Supplement/LB613.short
      – Glutamine deprivation with e.g. PhenylButyrate http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3510660/
      – Ketogenic Diet
      – Taurolidine, an IV treatment available at German clinics http://www.ncbi.nlm.nih.gov/pubmed/24762556
      – DCA (to be discussed here asap)
      All of the above may be relevant.

  3. Hello, I recently asked a question about GcMAF and Rerum. You mentioned something about the chondroitin that was a concern in advanced prostate cancer (or all prostate cancer). I can’t find that comment. Can you please respond what your concern is? I am interested in using the Rerum for my husband who has advanced prostate cancer (bone mets). Dollar for dollar, where is money best spent in the possibility of Rerum or the Methyglyoxal? Have you been able to connect with Dr. Ruggiero to discuss the issue of the chondroitin?
    Thank you very much for your time.
    Cathy

  4. Hi Cathy. You posted your question here https://www.cancertreatmentsresearch.com/?page_id=2 and on the same page you had my answer with the related concern. Next to that, you may want to read this recent post on Hyaluronic Acid https://www.cancertreatmentsresearch.com/?p=1489. In this post I did touched a bit Rerum as well. Based on the knowledge I have so far, I would use Rerum only in very early stage or to avoid recurrence. In advanced stages, I would stay away from products that may lead to increase of hyaluronyc acid production, which is the case for Chondroitin Sulfate (which is an ingredient in Rerum). Since you are asking me to compare the two, here is what I know today:

    Methylglyoxal:
    – clear since to support its anti cancer activity, even a Nobel Prize winner intensively publishing on that
    – long history as anti cancer solution
    – available to everyone as raw material, not a product developed and sold by a specific company, so no marketing behind
    – anecdotal reports and more importantly clinical trials results are available indicating (high) anti cancer effectiveness in late stage patients

    Rerum:
    – debatable anti cancer activity of Chondroitin (from Rerum), from a scientific point of view there are pros and cons why to use and why not (see https://www.cancertreatmentsresearch.com/?p=1489)
    – short history as anti cancer solution (is it actually promoted as an anti cancer solution or just immune stimulator?)
    – one company product with serious marketing behind, very expensive – if we really want to use it we can also buy and administer the ingredients (chondroitin, oleic acid, vitamin D3 and vitamin D2) separately and with this get a lower total cost
    – no clinical trials and not yet anecdotal reports

    Based on the above assessment, if I would look at prevention of recurrence I may consider Rerum, but if I would deal with late stage for of cancer I would avoid that while seriously considering Methylglyoxal option.
    I did not contact Dr. Ruggiero as I do not have the time. I heard only good things about him and I do not want to associate the above with him. I am just connecting the evidence available. I hope this helps Cathy.

  5. Hi, my father 66 years old is having a second relapse of Hodgkins Lymphoma. He previously suffered from Hodgkins Lymphoma in 1997 and 2004 and after chemotheraphy and radiation the disease was in remission between 1997 and 2004, and 2004 and 2016.

    He has several metabolically active lymphnodes in his body. Since the latest diagnosis in June 2016, he has received two rounds of chemotherapy and the doctors now believe that his body is not responding to chemotherapy. Is this something that could be potentially treated by high dose Vitamin C?

    I would really appreciate if we could get some advice on this and get him started on the treatment asap.

    1. Hi Hitesh,

      I am sorry to hear about your father. I hope he will get well soon.
      I cannot advice what treatments you should do but I can give you some examples: There are multiple options like chemo + see my post on how to make that effective, Salinomycin, 3BP, Diflunisal, Immunotheraphy, etc.
      The point is that due to lower response rate, Vit C to me is a supportive treatment. Next to that you need a treatment with higher chance of success such as those mentioned above.
      I hope this helps.

      Kind regards,
      Daniel

  6. Hi Daniel

    My father in law, aged 74, has been diagnosed with StageIV Gastric cancer (adenocarcinoma with peritoneal metastasis).

    The oncologists responsible have suggested to start chemotherapy under FOLFOX protocol which we did yesterday as they pointed out that we shouldn’t lose time without chemo.

    The last few weeks we have been searching over the internet for alternative treatments that may be beneficial to our situation. We came across therapies via Gcmaf, 2nd Generation Gcmaf, Rerum, Cannabis oil etc. To say the least we are confused to what we should follow.

    We do not object to any method of treatment (alternative and / or conventional) if it is going to be beneficial to our case. I would greatly appreciate it if you could please advise us based on your experience and knowledge which could be the best option to consider (provided we already started chemo) and what other treatments we should look into.

    Thanking you in advance

    Marios

    1. hi Marios,

      some thoughts…

      Antimetabolic therapy (ketogenic diet, metformin, DCA, glucose inhibitors etc) + chemo is effective for many people – i would do both at the same time. Above you can find good summaries from Daniel under “treatments”. As its stage 4 i would consider full body hyperthermia if its accessible for you. Be aware that most alternative or out-of-paradigm pages – unlike this one- are selling products and therefore are not interested in giving you the full picture.

      as to colon cancer specifically, wheat extract Avermar works against colon cancer cells according to some studies. It is inexpensive and can be taken with chemo. Even hardcore oncologists accept that it helps well-being during chemo and radiation as it reduces some side effects.

      1. Hi Wondering,

        Thank you for your thoughts and comments! I appreciate the time you put down to give me any of your views!

        These suggestions are part of your own experience or research? I apologies for these questions but i just try to get a grib of all these information given and evaluate them as best that i can.

        Thank you

        Marios

        1. hey Marios,

          I have cancer, hence my interest – I understand your confusion because of the overload of information. It can be difficult to find out what is mainly business and what works indeed.

          each cancer is different and there are so many options… pages like this can help your father in law a lot. I also recommend searching on ncbi. You can search for colon cancer studies, this one considers DCA as a potentially useful therapy:

          https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067498/

          My mother had stage 2 gastric cancer, recovered fully with chemo + radiation + Avemar. I dont know how much the latter helped but she thought Avemar reduced the side effects during the treatment.

            1. I greatly hope your overcome cancer as soon as possible. All my best wishes to you.

              I thank you of your input

      1. Dear Daniel,

        Hope you are well.

        Just a small note to kindly request again for your feedback/advise on my father’s in law case (see post at May 16, 2017 at 8:29 am)

        Thank you

        Marios

  7. Hi Daniel &community,

    First thank you for all of the information contained by these amazing pages.
    I would like to ask you for guidance for the following disease:
    04/2015 age 45 After breast ultrasound and mammography exams, due to a suspect solid tumor, drs proceeded to right breast excision of a 0,4/05 cm complex tumor consists of tubular adenosis with a very small area of tubular adenocarcinoma with necrosis in central part of the tumor , with microglandular adenosis and elastosis .
    stage 1 grade 1
    er 90%
    pr40%
    her2 neg
    ki65 3-5%
    p63 negative in mioepitelial ‘ carcinom tumour cells but positive in normal duct cells
    negative limph nodes (I+II)
    Partial breast radiotherapy 06-08/2017
    Doctors prescribed SERM tamoxifen
    After searching the medical studies and also NCCN’s protocol for tubular breast cancer histology i decided to not started with tamoxifen. Also a secondary reason was the uterine fibrosis diagnostic ( i had regular pelvic ultrasounds exams)
    Strated with betaDglucans+ acid betulinic supplement: Chaga + vitc +liver supplement
    melatonin
    q10 alternative with
    nigella sativa oil
    diet (reduce animal protein intake+ synthetic carbohydrate )
    metformin
    cucurmin
    i noticed about drug re purposing, but not started yet: i have in mind :mebendazole, omeprazole, cimetidine, doxiciclyne

    My questions are: do you know if are some supplements that can reduce the body produced estrogen and xeno-estrogen intake?
    regarding the early stage & favorable histology your recommendation in terms of frequency of supplements usage? continuously or having some intervals without (by ex metformin i am taking it 2 months and 2 months pause).
    other suggestion in terms of how can i plan an overall and long term strategy for minimizing the relapse possibility.

    Many thanks,
    crina

  8. Hi Daniel,

    My crew (focusing on my dad Terry Millar, diagnosed w stage IV pancreatic cancer Oct of this year) has just found your site. We are blown away by what you have done here. I am sure I’ll be getting in touch with questions and also with some suggestions, but the first thing I wanted to do was send you our gratitude.

    When I read about your wife I cried. I am sorry.

    1. Dear jmillar,

      Thank you so much for your msg of appreciation. I am sorry to hear about the diagnosis. Unfortunately, cancer became such a common disease … Just let me know if there are questions, and if it is something personal you can also send me an e-mail.

      Kind regards,
      Daniel

  9. Hello Daniel,

    Came across your website accidentally this week as I was studying about cancer treatments. Congrats on what you´ve done here. I totally relate to your story since my mother and father have been fighting stage iv breast and prostate cancer. Since 2014 I ve been studying a lot to help them as you did with your family. Would it be possible to send me that material on breast cancer you mentioned above?
    I would like to know your opinion also on this subject .My mother had her blood tested in the Greek liquid biopsy and among others her case showed sensibility to Vit C and Artesunate. So we began a Vit C protocol along with phospoethanolamine( chierice´s formula). At start ,10g and each session growing up to 50 g. 2x/week. Started in august and by the end of september her pleural edema that was very small got bigger, as did her lung metas. I felt insecure about vit C and changed the protocol for chemo with Capecitabine , IV ozonetherapy and a combination of chierice´s phospho and Dr Nieper´s supplements protocol (Ca , Mg AEPs, Ca orotate, Squalene,Membrane complex, Digestive enzymes , among others). I´m seriously thinking about starting dissulfiram +zync or DCA. Could you give your view on this options ? Another strategy you can advise? Do you think is worthy trying VIt C again with Capecitabine?
    I´m still getting acquainted with the site and trying to read as much as possible .
    Thanks so much
    Marcio

    1. Dear Marcio,

      Thank you for your comment. First, I will now send the report to your e-mail and when I will have the time I will respond to the other questions. If I forget please remind me.

      Kind regards,
      Daniel

    2. Hi Marcio!

      http://www.telegraph.co.uk/news/2017/09/26/prostate-cancer-treatment-could-cure-men-no-hope/

      Vitamin C has been a large revelation to me in 2017.
      https://www.cancertreatmentsresearch.com/high-dose-vitamin-c-cancer/#comment-6440

      lullabyman pointed me to the original research from the 1970s.
      From what I understand now, prolonged iv dosing (i.e. perhaps 10 hours per day of roughly 1 gram per hour) should have
      a large therapeutic effect. Did you dose at roughly 1 gram per minute? I would be very very interested to see what would happen with slow dosing.
      http://www4.dr-rath-foundation.org/NHC/studien_pdf/old/the_orthomolecular_treatment_of_cancer.pdf

  10. Dear Daniel,
    I was looking for alternative treatment and found your webside. Very informative, I really appriciate what are you doing.
    I have my spouse with non small cancer stage 4 metastatic to brain. Chemo, radiation and Opdivo done. Right now he is getting immunotherapy drug TECENTRIQ® (atezolizumab), but seems it is not working as well. He is in pain and I really want to start 3BP, DCA ASAP. I read books about metabolic approach to cancer (Christofferson, Seyfried) and my spouse has started ketodiet. I have limited financial ability, and I couldn’t afford to go to clinics. Could you please guide me from where I have to start? Do you have data about safety when administrating 3BP and DCA to patients with brain mets? Time is critial for us and I would really appriciate if you could help me. God bless you, Nika ([email protected])

    1. Dear Nika,

      I am sorry. Please take care with these immuno therapies in terms of side effects. At German clinics anti PDL1/PD1 are used at a monthly dose 6x lower compared to the recommended one in order to lower the side effects – and they claim the effectiveness remains the same, when that is effective. I can do my best to help you by sharing what I know but please note that everything comes with the Disclaimer from this website. I have no data in terms of safety other than that shared on the post’s pages and the anecdotal info I have from own experience and other’s experience. You have to realize that when taking such route, you are walking on a path that is still new, not fully known and as a results it has it’s own potential but also own dangers. If you understand these points and agree, and still want to explore them, I will do my best to share what I know as I understand the pain of not having other options. If you like you can send me an e-mail with your Skype or FB account ID and availability + location (to know the time difference). I could find time tomorrow or maybe in the weekend. Also, please read in advance the posts I wrote on the substances you are interested in. Thank you.

      Kind regards,
      Daniel

    2. Hi Nika. I received your e-mail but could not find anyone on Skype with the ID you gave me. Please check your e-mail – you have my ID and will be available to speak today. Kind regards, Daniel

  11. HI Daniel

    In Sep 2018 had a undifferentiated pleomorphic liposarcoma removed from my bicep (had previously removed 6 xs from a GP who had incorrectly diagnose as Lipoma Cyst for 2 1/2 years beforehand).
    I had clear margins after wide resection.
    I declined chemo and radiation.
    My diet has changed drastically but I have recently learnt the UPS uses nucleotide metabolism.
    How does my diet now need to be addressed – do I still starve any potential cancer cells of sugar. I am mostly vegan (sometimes do a slice of cheese and have health bread that may have an egg in it)
    I juice 2lts of vege juice a day
    I add the following to my diet:
    Ashwaganda
    Super greens including spirulina/ wheatgrass/ barley/ broccoli
    Maca
    Zeolite
    Artemisian (parasite mix with cloves)
    Milk thistle
    Immune System booster tablets
    Flaxseed
    Curcuin
    Tumeric
    THC edibles – upto 50mg a day
    RSO oil
    Blackseed cumin oil

    Please advise what else I can be doing to ensure a return of homeostasis to the body – I also lost a lot of weight and am trying to rebuild – please guide what is best here
    I do crossfit
    I would like to prevent possible distant metastasis or even a recurrence.
    If there is no present tumour in a persons body are there still drugs that would be recommended as precaution

    Thank you for been so gracious in giving me the opportunity to ask my questions
    Kindly
    Lee

    1. Dear Lee,

      Thank you for your comment. Your question relates to diet, supplements and drugs that could help to inhibit recurrence of tumors. Here I answered a similar type of question https://www.cancertreatmentsresearch.com/community/stomach-cancer/gastric-cancer-treatment/#post-904

      I am not an expert in diet but 2lts of juice/day could be a little too much?

      UPS seems to be an aggressive sarcoma – to be aggressive tumours require high amounts of glucose. So limiting that in the diet would be good. Metformin may also help as prevention in this case as it also limits the liver capability to generate glucose as discussed here https://www.cancertreatmentsresearch.com/addressing-gluconeogenesis/

      Based on this study https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5751264/ it may be that microtubule dynamics inhibitors can help. Two such inhibitors have been addressed on this website Mebendazole and Fenbendazole. For each, I wrote a specific post:
      https://www.cancertreatmentsresearch.com/the-over-the-counter-drug-mebendazole-acts-like-chemotherapy-but-with-virtually-no-side-effects/
      https://www.cancertreatmentsresearch.com/fenbendazole/
      Cycles of Griseofulvin may also help but it has some toxicity to the liver https://www.cancertreatmentsresearch.com/griseofulvin-like-chemotheraphy-but-without-its-side-effects/

      I hope this helps.

      Kind regards,
      Daniel

  12. Hi Daniel – I have been diagnosed for prostate cancer in the year January 2018 and it was Stage 4 involvement of lymph nodes – I have been on quarterly hormonal injections ( Lupron ) and daily 50 mg (Casodex ) since then and i have been following up my PSA regularly . recently my PSA has jumped up to 3.64 in the beginning of October this year . I want to opt for Fenben treatment protocol and if you can help me in guiding rightly that would be great – Basically on the protocol on how to take it etc etc and days off and days on . Anything to go along with it ? quantity to be taken daily etc etc – Best regards

    1. Dear habibisamarika,

      For Fenbendazole, administration please read this post https://www.cancertreatmentsresearch.com/fenbendazole/ it includes all the info you requested. As you will see, it is usually taken at a dose of 222mg/day (that is 1g granules/day of Panacur) 3 days ON and 4 days OFF.
      However, I would not rely on Fenbendazole alone. Instead, I would use Fenbendazole next to other treatment approach that can increase the chance of success. For more ideas on what else could be done please read the following:
      https://www.cancertreatmentsresearch.com/prostate-cancer/
      https://www.cancertreatmentsresearch.com/a-visitor-story-healing-from-stage-4-prostate-cancer-with-fasting-and-juicing/
      https://www.cancertreatmentsresearch.com/community/prostate-cancer/
      https://www.cancertreatmentsresearch.com/summary-of-this-website/

      Kind regards,
      Daniel

    1. Dear AMorley,

      I see no reason why the two cannot be combined, and I think it may actually be a good idea.
      This is because the two drugs have different targets Griseofulvin has affinity for gamma-tubulin (Ref.) while Fenbendazole has affinity for beta-tubulin (Ref.).
      More about the role of different tubulin types can be found here while a good picture related to this can also be found here.

      Therefore, combining these two may be a good idea to increase the chance of reaching the goal, i.e. interfering with the microtubule dynamics and as a result tumor growth inhibition and possibly death.

      I hope this helps.

      Kind regards,
      Daniel

  13. Hi there
    I’ve got the BRCA2 gene mutation. Long story short. Fighting breast cancer since 2010. Breast cancer metastasis to the bone (rib) and now to the liver. Estrogen and progesterone positive. Starting chemo next week. Also seeing a Dr about Vit C and oxygen infusions. Also very interested in the deworming product

    I’m desperate and would appreciate your help and input.

    Kind regards
    Julienne

    1. Hi Julienne,

      What is the chemo you are going to start?
      What are other supplements and repurposed drugs you are using or planning to use other than Fenbendazole, Vit C and oxygen?

      Kind regards,
      Daniel

  14. Help us Asian People with Severe Coronavirus Pneumonia from Irresponsible and Ignorant Bureaucrats, Japan.

    Dysregulation of pro-inflammatory cytokines promotes immune-mediated injuries 1.
    Both epithelial-cell proliferation and an increase in macrophages in the lung are associated with SARS 2. Pathogen-associated molecular patterns (PAMPs) such as 2019 novel coronavirus, proinflammatory cytokines, and lipopolysaccharide (LPS), cause macrophage transition. Macrophages activated in this transition termed M1 macrophages that promote inflammation 3. PAMPs are primarily sensed by members of the Toll-like receptor (TLR) family and this sensation activate transcriptional factor NF-κB that promotes secretion of proinflammatory cytokines 3. Activated or infected immune cells secrete excessive proinflammatory cytokines including MIP-1α, RANTES, IP-10, IL-1-6-8, TNF-α, TGF-β1, MCP-1and MCP-1 4. These cytokines promote severe lung injury 1.

    Thalidomide is an immunomodulatory agent with strong antiangiogenic properties with COX-2 inhibitor celecoxib. Thalidomide inhibits the mRNA encoding such as TNF-α and VEGF. In addition, thalidomide modulates activated or irregulated NF-κB, resulting in suppressing severe lung injuries.
    https://www.researchgate.net/profile/Masato_Hada/research

    However, we are ordered not to conduct clinical trials with thalidomide and celecoxib by Ministry of Health, Labor and Welfare, Japan. Because thalidomide is the dangerous drug.

    I think it would be difficult to save the patients with severe pneumonia who could be saved with this regimen in the future.

    I would like you to recommend to the Japanese Ministry of Health, Labor and Welfare to take appropriate measures in Japan from the Form.
    https://www.kantei.go.jp/jp/forms/goiken_ssl.html

      1. @Daniel: Dr. Hada makes a good point, that the acute lung injury, induced by the inflammatory cytokine storm (similar with SARS), could possibly be attenuated by the combination of Thalidomide and Celecoxib. However, IMO Japanese authorities are unlikely to listen to any foreign recommendations, since they would lose face.
        There is some information about the 2019-nCoV, that I’d like to share here:
        – this coronavirus is highly contagious, and has the potential to become a pandemic;
        – the mortality rate of (early) hospitalized patients (presumably only on supportive care) appears to be about 11%;
        – elderly (over 70) patients (possible similar vulnerability with cancer patients after chemo) have done much worse;
        – drug combinations, that were used against SARS and MERS, are currently tested, possibly successful;
        – a vaccine will take several months to develop and test, and in the meantime this virus could spread globally;
        – the combination of Kaletra (Lopinavir/Ritonavir) and Tamiflu (Oseltamivir) may be useful against 2019-nCoV;

          1. Rendesivir is much more expensive and must be used intravenously .
            Chloroquine is much less potent in treating cytokine storm, i’ve read an old article http://ila.ilsl.br/pdfs/v31n2a04.pdf
            on using it in lepra reactions. There was some symptoms improvements, but much less effective than thalidomide.
            You can look at this survey (Thalidomide in leprosy–study of 94 cases) https://www.ncbi.nlm.nih.gov/pubmed/3572098
            Also, It’s interesting to see photos of how thalidomide can make improvements in this type of reactions (The use of Thalidomide in childhood TB meningitis) http://www.oucru.org/wp-content/uploads/2017/07/Session-2-Part-3-0930-Schoeman_revised.pdf
            Also, Thalidomide stimulates T cell responses and interleukin 12 production in HIV-infected patients
            https://www.ncbi.nlm.nih.gov/pubmed/10480630
            So, there’s no reason not to evaluate it for COVID 19 pneumonia treatment.

        1. strange thing, young people succesfuly withstand the infection with 2019-nCoV and don’t need any antivirals and the body clears the virus by its own means.
          so, maybe by stimulating the immune system (or modulating its response) patients in the risk group could cope with the desease with their own immune system without developing pneumonia at all.

      1. I think as the COVID 2019 makes its debut in European countries makes it more relevant. i did my research of multiple papers written by different authors and using Thalidomide to treat the reactions of this type as COVID 2019 pneumonia (they have very common symptoms although can affect different organs). – it helps in cases when different treatments are unsuccesful (ativirals, antibiotics, glucocorticoids) just by modulating the immune response.
        https://www.minervamedica.it/en/journals/gazzetta-medica-italiana/article.php?cod=R22Y2000N02A0065
        https://journals.lww.com/pidj/Abstract/2016/11000/Thalidomide_in_Refractory_Tuberculomas_and.23.aspx
        And in Lepra reactions it works in 99% of cases in the first 24 – 48 hours of treatment (THALIDOMIDE IN THE TREATMENT OF LEPRA REACTIONS. SHESKIN J.)
        The COVID 2019 pneumonia is the same type of reaction, although triggered by a different agent.
        But i can not help to the Masato Hada’s cause, because this field is heavily regulated and thalidomide is teratogenic and will be met with prejudice by any regulating government organ.
        So i synthesized a batch for myself, knowing very well that nobody can help you better than yourself.

  15. Hi Daniel,
    KINDLY HELP SAVING MY MOM ?

    I had become a big fan of you after reading your story on website and for the incredible help you are doing for cancer patients and caregivers.
    Sorry for your wife.

    My Mom(T INDHIRA) 45 years was dx mucinous adenocarcinoma ovarian cancer and all her earlier treatments first surgery, chemo, hipec,avastin,opdivo didnt help.
    Now we started her on off label drugs to block multiple pathways and on medium dose chemotherapy.
    In recent ultrasound scan, radiologist says that, all the tumors has grown in size (largest being 16 cm)and every tumor has cystic formation inside by cells dying but as these tumors are bulging, compressing the adjacent organs causing complications.
    Im skeptical if she is responding or not.Can you please guide on what can be done for cystic tumors.

    Below are off label drugs im giving her.
    BetaGlucan Transfer Point 500mg
    Curcumin BCM 95 500mg X 2
    Cimetidine 400mg X 2
    Quercetine 500mg
    Bifio Probiotic 10 Bilion
    Hydroxychloroquine 200mg
    Metformin 500mg X 3
    Nitazoxanide + Multi Vitamin(iron & copper free) 500mg
    Depakote (volporic acid) 250mg X 2
    Asprine 80mg
    Wob Enzyme 4 capsules
    Ascorbic Acid Vit C Oral 5-6g
    Milk Thistle (Silybum) 250mg
    R-ALA 250mg
    Vit E Tocotrienols 400mg
    Albendazole/Mebendazole 300mg
    7 Kteo DHEA 100mg
    Mushroom Turkey Tail 250mg
    EGCG 400mg
    HydroxyCitrate 600mg
    Berberine 600mg
    T Tadalafil 20mg
    Desloratidine 5mg
    Doxycycline 100mg
    2DG 1.5gm
    LDN 4.5mg
    Atorvastation 20mg
    Losartan 20mg
    Melatonin 300mg
    Imiquimod cream 1 pc
    Idrofos (monthly) 150mg
    Turpentine oil + Black seed oil
    Cranberry 500mg.
    Please suggest in tailoring the list and dosages.

    Regards,
    Karthik
    skype id: karthikreddie

    1. Hi Karthik,

      I am so sorry. Please let me know what is the chemo that is used now and the frequency, and I will try to find time to think.
      So far I would say that most of the doses you use are too low. Maybe lowering the amount of capsules and increasing the dose would be a first step to take. I will try to respond asap. Maybe other people will hep in the mean time.

      Kind regards,
      Daniel

    2. Hi Karthik,

      sorry to hear this. When was your mom’s dx? What happened on the first round of chemo(cisplatin)?

      I see quite a few strong antioxidants(Vit E Vit C ALA) on your list of drugs and supplements and taking antioxidants on chemotherapy treatment could reduce the effectivenesss of the chemo.

      My sister-in-law, 42, has ovarian cancer stage 4, dx oct 2016, she finished carboplatin 10 days ago, previously had surgery, cisplatin/taxol, avastin 22 rounds, recurrence in August, cisplatin taxol. Some cancer seems to be left.

      She started mistletoe (helixor M) a few days ago. I’ll let you know if this is something she responds to. She’s also switching to a plant-based diet again(she did in the very beginning too but it’s not an easy diet for her).

      I’d add plenty of sulforaphane to her regimen.
      https://www.spandidos-publications.com/10.3892/ijmm.2018.3860

      I’d increase the curcumin. Maybe combine 95 with some other good formulations:

      BioCurc®
      CurcuWin®
      Longvida®
      CAVACURMIN®
      TetraCumin-QR

      Regards,
      Johan

    3. Hi again, in my previous message I mentioned sulforaphane and since curcumin and aspirin are already part of your mom’s supplement plan, here’s another study showing synergistic activity with the triple combination of Aspirin+Curcumin+Sulforaphane:
      “As shown in Fig. 2A, individually, the chemopreventive agents did not show significant change in cell viability at these concentrations, thereby demonstrating an ineffective profile. However, when used in combination at same concentrations, ACS showed a significant synergistic effect with a reduction in cell viability of MIA PaCa-2 cells by as much as ~70% (P<0.001). Fig. 2B demonstrated similar results with Panc-1 cells, where combinations of ACS showed a remarkable decrease of ~75% (P<0.001) in cell viability. Notably, when only dual combination studies of ASP with either CUR or SFN were conducted at the same concentration, there was no significant decrease in cell viability, with only ~20% decrease being observed from dual combinations (data not shown). Thus, the triple combination of ACS administered at low concentrations showed a significant reduction in cell viability."
      https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621734/

      1. Hi Johan,

        Thanks for responding.
        Below is history of mom.

        My Mom(T INDHIRA) 45 years was dx mucinous adenocarcinoma ovarian cancer in October 2015, undergone CRS surgery and later she didn’t take chemo therapy and did some alternatives. She had reoccurrence in 2018 april, then oncologist started carboplatin + paclitaxel chemo for 6 cycles, though her general condition improved, a followup scan after 6 cycles chemo shown disease progressed a lot.
        My mom’s cancer is MSI HIGH, TUMOR BURDEN HIGH and BRCA 1 & 2 negative(somatic & germline).

        After that she had undergone CRS + HIPEC surgery in april 2019( its been 3 months) ,after 2 months doctor started bevacizumab + gemcitabine( took 3 cycles).We did an PET CT scan after avastin and disease progressed. It reoccurred in just 3 months of HIPEC surgery.

        Now our doctor prescribed Nivolumab for every 15days.After 3 infusions of nivolumab her Tumors doubled in size.

        We have started her on carboplatin gemcitabine chemo with low dose nivolumab. And we are also giving many off label drugs to block multiple pathways,but not seems helping.
        In recent ultrasound scan, radiologist says that, all the tumors has grown in size (largest being 16 cm)and every tumor has cystic formation inside by cells dying but as these tumors are bulging, compressing the adjacent organs causing complications.
        Please help.


        Thanks & Regards,
        Karthik,
        Skype : karthikreddie

      2. Hi Johan,

        Im giving her metformin, berberine, quercetin, satin and 2DG etc. Can you please let me know is sulforaphane available in medical form or is it only from broccoli sprouts.
        Ovarian cancer is notorious.

        Regards,
        Karthik

        1. Here are a few good SF supplements:

          BroccoMax (Jarrows Formulas)
          Avmacol®
          Organic Broccoli Sprout Powder (Health Ranger)
          NanoPSA

          I’d combine supplements with enough broccoli sprouts daily and of course broccoli, cut in smaller pieces and let sit 40 minutes, this activates the sulforaphane. You can then cook or roast the broccoli.

          Lycopene (https://news.illinois.edu/view/6367/211101) and selenium (http://news.bbc.co.uk/2/hi/health/2903739.stm) could provide additional beneficial synergies (in combinations with SF). For Selenium, yeast bound selenium and/or sodium selenite are probably the best choices

          Lycopene, as single agent in ovarian: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5489781/

          Quercetin, seems a good choice in ovarian cancer: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6570913/

          Selenium: https://academic.oup.com/jn/article/147/4/621/4630434

          1. Hi Johanna,

            Below is my Mom’s history

            My Mom(T INDHIRA) 45 years was dx mucinous adenocarcinoma ovarian cancer in October 2015, undergone CRS surgery and later she didn’t take chemo therapy and did some alternatives. She had reoccurrence in 2018 april, then oncologist started carboplatin + paclitaxel chemo for 6 cycles, though her general condition improved, a followup scan after 6 cycles chemo shown disease progressed a lot.
            My mom’s cancer is MSI HIGH, TUMOR BURDEN HIGH and BRCA 1 & 2 negative(somatic & germline).

            After that she had undergone CRS + HIPEC surgery in april 2019( its been 3 months) ,after 2 months doctor started bevacizumab + gemcitabine( till now took 3 cycles).We did an PET CT scan yesterday and disease progressed. It reoccurred in just 3 months of HIPEC surgery.

            Now our doctor prescribed Nivolumab for every 15days.After 3 infusions of nivolumab her Tumors doubled in size.

            We have started her on carboplatin gemcitabine chemo with low dose nivolumab. And we are also giving many off label drugs to block multiple pathways,but not seems helping.
            In recent ultrasound scan, radiologist says that, all the tumors has grown in size (largest being 16 cm)and every tumor has cystic formation inside by cells dying but as these tumors are bulging, compressing the adjacent organs causing complications.

            I had attache the list of off label drugs we are giving, please help me in tailoring the drugs and dosage.


            Thanks & Regards,
            Karthik,
            Skype : karthikreddie

            1. Hi Karthik,

              I agree with daniel’s observation about the amount of drugs and supplements, more doesn’t necessarily equate to better. Combinations can lead to additive or even synergistic effects, but can also be antagonistic. As mentioned in my first response, the supplementation of powerful antioxidants(VIT C,E,ALA) in sufficient doses alongside a pro-oxidant therapy could potentially reduce the effectiveness of the pro-oxidant treatment. You might want to read Daniel’s post https://www.cancertreatmentsresearch.com/shutting-down-the-power-house-of-cancer/

              There are supplements that have been found to enhance chemotherapy, the following natural compounds could enhance the effectiveness of carboplatin in ovarian cancer:

              berberine(on your list) https://biolres.biomedcentral.com/articles/10.1186/s40659-019-0243-6
              ursolic acid(not on your list):https://pdfs.semanticscholar.org/df9b/c9e4b46cf0d9ab697ae089c3e6458601fc32.pdf
              ashwagandha(not on your list):https://www.ncbi.nlm.nih.gov/pubmed/25264898
              bitter melon(not on your list): https://www.ncbi.nlm.nih.gov/pubmed/26487740

              As mentioned in my reply above, I’d increase the curcumin. Maybe combine 95 with some other good formulations: BioCurc® CurcuWin® Longvida® CAVACURMIN® TetraCumin-QR

              I’d add plenty of sulforaphane to her regimen. https://www.spandidos-publications.com/10.3892/ijmm.2018.3860
              Sulforaphane, an indirect antioxidant, may improve the efficacy of chemotherapy:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5099878/

              I’d keep the Aspirin: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3621734/

              Betaglucan, unsure about this because your mother is currently taking an immune suppressor (Nivolumab). Might want to keep this one for later.

              Quercetin, I like this one, it’s also a natural parp inhibitor. PARP inhibition has proven effective in ovarian cancer, especially in ovarian with BRCA mutations, which}is not your mom’s case
              but even in BRCA negative ovarian cancer PARP inhibition can help. You could ask your oncologist about Olaparib / Niraparib / Rucaparib, potent PARP inhibitors.

              EGCg, good one, might want to consider using it in combination with indole-3-carbinol (I3C): https://bmccancer.biomedcentral.com/articles/10.1186/s12885-018-4792-9

              Turky tail, melatonin same remark as with betaglucan. I’d check with Daniel.

              Black cumin seed oil, OK. A little vitamin D3 and magnesium may enhance the thereapeutic effect of this oil.

              You mention your mom’s cancer is MSI high. In this study, in colorectal cancer:

              “Of significance, no p53 mutations were detected in MSI-high tumors” https://www.nature.com/articles/1202109

              This could open a new line of treatments, I’d ask your oncologist what he/she thinks about this.

              This could be of interest(low folate):

              “low-folate stress could induce apoptosis in cancer cells, and that this effect required functional (non-mutated) p53 and involved increased production of a type of molecule known as ceramide (Hoeferlin et al., 2013). New research published last year (Fekry et al., 2016) now provides details as to how this process takes place. They found that low folate activates p53, activated p53 enhances transcription of the CerS6 gene, and increased CerS6 causes increased production of ceramides, ultimately resulting in apoptosis. These results highlight how nutrient
              levels can influence cell growth, replication, and death.”

              https://transforming-science.com/featured-research/diet-enhances-natural-anti-cancer-response/

              Also:

              “in wtp53-bearing tumours, the main approach is to block p53 inhibitors, such as Mdm2 and MdmX, or the viral E6 oncogene in human papilloma virus (HPV)-driven cervical cancers (Fig. 1).”
              https://onlinelibrary.wiley.com/doi/pdf/10.1111/joim.12336

              Hope this helps,

              Johan

  16. Hi Daniel,

    Currently she is doing as below
    Day1 : Carboplatin (500mg) + Gemcitabine (1600mg)
    Day8 : Gemcitabine (1600mg)
    Day15 :Nivolumab (40mg) (only one infusion given, after this her abdomen swelling increased)

    Day30/Day1: Repeat.

    I recently started giving 2DG orally , half teaspoon before every meal with metformin 500mg and hydroxychloroquine 200mg.

    I had sent you an email of complete prognosis .Please help.

    Regards,
    Karthik,
    skype : karthikreddie

    1. Dear K,

      From what I understand from your comment above, the tumours are very large. The best way to go forward in this case would be debulking via surgery, at least the largest one (16cm). Assuming that is not possible, at this point I would very much focus on serious “guns”.

      First, a short feedback on the list you sent me:

      Pantop 40mg
      – best to change with Lanzoprazole
      BetaGlucan Transfer Point 500mg
      – No oppinion
      Curcumin BCM 95 500mg
      – Too low dose
      Cimetidine 400mg
      – Very good but may interact with drugs so I would remove in order to introduce new drugs in a safer way
      Quercetine 500mg
      – Too low dose – either increase the dose or stop
      Bifio Probiotic 10 Bilion
      – Good
      Hydroxychloroquine 200mg
      – Must keep with chemo – now possibly not effective because the tumor is too large and the pH around the tumor protonates the drug
      Metformin 500mg
      – Good but its low dose – best 1000mg if possible
      Nitazoxanide + Multi Vitamin(iron & copper free) 500mg
      – maybe stop to make space for others
      Depakote (volporic acid) 250mg
      – I would keep
      Ezact 60mg
      – I do not know this one
      Wob Enzyme 4 capsules
      – Good but I woudl remove to make space for other pills at this point
      Ascorbic Acid Vit C Oral 5-6g
      – good but not with chemo – change to either lower dose or much higher intravenous dose
      Milk Thistle (Silybum) 250mg
      – good – I would keep
      R-ALA 250mg
      – i would remove
      Vit E Tocotrienols 400mg
      – I would remove
      Albendazole/Mebendazole 300mg
      – I would keep if possible
      7 Kteo DHEA 100mg
      – I would remove due to the hormonal impact – I will mention another drug to address anti-oxidant production
      Mushroom Turkey Tail 250mg
      – I would keep
      EGCG 400mg
      – I would remove because the dose is so little that is like nothing anyway
      HydroxyCitrate 300mg
      – too tittle dose – needs to be 1.5g/day
      Berberine 600mg
      – If Metformin will not be increased I would increase this one
      T Tadalafil 20mg
      – no oppinion
      Desloratidine 5mg
      – no oppinion
      LDN 4.5mg
      – if using for long time I would stop – otherwise continue
      Atorvastation 20mg
      – this is too little – I woudl increase the dose to at least 40mg/day
      Losartan 20mg
      – no opinion – maybe remove
      Melatonin 180mg
      – I would reduce to 20mg as it is very high and it has anti-oxidant properties – now the goal is to make chemo effective
      Imiquimod 1 pc
      Idrofos 150mg
      – no opinion
      Doxycycline 100mg
      – it’s suitable
      2DG 1.5gm
      – no point to use it orally – it will not do anything – to be effective it has to be done intravenously and metronomic

      Essentially, my point is that if I would be you, I would focus now on making chemo effective. This is because the tumors are too large to be able to control them with supplements or low dose repurposed drugs. As a result:
      – I would lower the amount of antioxidants currently used and make sure that I do not use them the first 5 days after chemo and two days prior – which means that when using chemo every 7 days, there is no more time to use anti-oxidants at this point
      – the tumour is large and produces a lot of acidity. This will make Gemcitabine ineffective. Therefor, I would do my best to eliminate that acidity prior to chmo. That can be done with NaBicarbonate intravenous prior to chemo. Some are also using DCA for that reason but I am not sure it would do much in this case. Another option is to use proton pump inhibitor cluster of drugs https://www.cancertreatmentsresearch.com/ph-cancer-a-top-treatment-strategy/ However, the easiest is to give NaBicarbonate intravenous prior to chemo
      – What I would also do is to use Verapamil to try inhibit MDRs (applied continuously regardless of the days of chmo)
      – I would address anti-oxidants using: Auranofin if available, Sulfasalazin, Retinoic Acid
      – I would use metronomic 2DG after chemo if you have access to that – it’s available at a pharmacy in Germany and very cheap
      – I would use Ritonavir if available to stop GLUTs – shoudl be very effective and should help chemo effectiveness
      – I would add Canagliflozin
      – I would use Vitamin C in high dose intravenous a few days after chemo
      – If there is pain, best is to use Diclofenac as anti-pain as it is a LDH inhibitor
      – I would consider adding Thalidomide https://www.cancertreatmentsresearch.com/thalidomide-once-alleviate-morning-sickness-in-pregnant-women/ that should work very well for large tumors and also in combo with Valproic Acid (which you use already) and Celecoxib. It should help a lot on short term.
      – I would add Silver solution as well due to anti-bacterial, anti-Candida, anti-viral and many other relevant properties https://www.cancertreatmentsresearch.com/a-silver-bullet-to-kill-cancer/ This totally cured a man with metastasis, in 3 months.
      – I would use anti-inflammatory including Olive Leaf Extract

      The doses for most of the above have been discussed in the website and you will be able to find. If you do not find please let me know and will find them for you.

      I hope this helps for now.

      Kind regards,
      Daniel

      1. Hi Daniel,

        Thanks a lot for responding.
        Noted the changes suggested.

        1.can you please share IV 2DG source contact from Germany. We brought oral 2DG from China.
        2.And can you please also share the metronomic 2DG protocol and dosage
        3. In recent ultrasound scan, radiologist says that, all the tumors has grown in size and every tumor has
        cystic formation inside by cells dying and its not the solid growth . Can you please explain, if this
        can be considered as response for metabolic drugs and chemo, which we are giving from 3 months.
        4.** need and urgent suggestion**
        After watching Dr. Vikas P. Sukhatme recommendation on Ketorolac IV to reduce inflammation caused by immunotherapy
        for making chemo effective, we have my mom two ketorolac iv 30 mg each with 100ml NS yesterday and after iv, her
        abdomen, legs and thigh swollen and urine output drastically reduced.
        The creatinine and blood urea values are good before this IV.
        Can this be due to kidney issue? Giving lasix will help? Please suggest.
        Thanks & Regards,
        Karthik.

        1. Hi Karthik,

          You are welcome!

          1. The pharmacy in Germany that has 2DG for intravenous admin is listed here at the top of the compounding pharmacy list (Burg Apo) https://www.cancertreatmentsresearch.com/suppliers/
          2. To apply 2DG intravenously in a metronomic way, I assume you are helped by a medical trained person. It is best that your medically trained caregiver will contact prof Lampidis to request for the treatment protocol. You already have the contact details of prof Lampidis and he responds usually very fast. If that is not possible due to any reason, please let me know and I will help.
          3. In this case I would hope for the best, and because the tumor grew and is large I would increase the strength of my treatment strategy and not just maintain as is. In a previous response, I gave you some ideas about additional approaches that I consider relevant in this case
          4. Edema can be triggered by so many mechanism. Here is a diagram that can help identify the origin of edema https://www.aafp.org/afp/2013/0715/p102.html#afp20130715p102-f1 Please check with your doctor too – this is their field of expertise and they should be able to identify the origin.

          If there are other questions, please let me know.

          Kind regards,
          Daniel

          Kind regards,
          Daniel

  17. Hi Johan,

    Thanks for elaborated reply.

    So ,as said in the article that MSI-I cancers doesn’t have p53 mutations, there is new treatment in India called as CYTOTRON .
    This a machine, which rejuvenates the cell potential and switches back the P53 and we are planning for this treatment.So, as per above article, this treatment may not be effective right?
    Please suggest.

    As immunotherapy increased inflammation a lot and flared up the disease, yesterday we gave 2 infusions of ketorolac iv 30mg each in 100ml NS.After the 2 IVS of ketorolac(in thought of making next chemo effective) but her legs thighs abdomen swollen and urine output is drastically reduced.

    Regards,
    Karthik

  18. Indeed, in the case a tumor doesn’t have mutp53 I don’t see much benefit for that type of treatment. But that’s just my opinion, I’d check that with someone more knowledgeable on the topic.

    Regards,

    Johan

    1. Hi Johan,

      Radiologist says that all the tumors increased in size but every tumor has cystic formation due to cells dying off and tumor size is not solid growth . Does this mean that , the current protocol has some response.
      my mom’s abdomen,legs and thigh swollen after giving ketorolac iv today and her urine output stopped(which was fine yesterday).
      Can you please share Daniel’s skype id on my email ([email protected]), so that I can get some inputs immediately, awaiting response,I understand he must be busy but I’m scared that situation getting worse.Thank you.

      Regards,
      karthik.

  19. Hi Daniel,

    I had a question about a particular drug (Apatone, 100:1, Vit C: VK3), there was very promising studies done around 2008 but there was lack of funding from the company and no other info can be seen. This combination of these 2 vitamins caused cancer cell death in an unique way called autoschizis. The oral drug was meant to be adjutant to chemo but I have read some testimonials that that the IV version did much better at fighting the cancer on it’s own. Have you heard of this medication during your research? If so what can you comment about it? Thank you in advance for all your help!!

    1. Dear catsrule,

      Thank you for pointing out Apatone. I shortly touched this while discussing relevant options from prostate cancer https://www.cancertreatmentsresearch.com/prostate-cancer/
      Overall, I think it’s a relevant option that has been already demonstrate to at least reduce the speed of progression https://www.medsci.org/v05p0062.htm and can be implemented as a part of a more comprehensive treatment strategy. When used at lower dose (e.g. vit c at 5g/day and k3 at 50mg/day) there are still indications from scientists that this would act as a pro-oxidant. here is a more recent paper on that discussing the mechanisms: https://www.sciencedirect.com/science/article/pii/S2214854X15300066#!
      So overall I am positive about this approach. It could make sense to contact on of the main author involved in Apatone which seems to be Dr. Jacques Gilloteaux and his e-nail address is jgilloteaux (at) sgu.edu

      Kind regards,
      Daniel

  20. Hi Daniel,

    Thanks for your prompt reply, I have send an email to Dr. Jacques Gilloteaux… I had another question… any research on Adenanthin? It’s a supplement. Apparently there’s a gene thats expressed in cancer cells that shut off NK cells https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3701951/#__ffn_sectitle
    adenanthin helps with the NK cells https://www.ncbi.nlm.nih.gov/pubmed/26094816… is this correct?

    Thank you again for all your help!

  21. Hi Daniel,

    Thanks for responding.
    Me and Our physician had a meeting with Dr Lampidi, where he explained about metronomic 2 DG protocol, which is 1g -2g for 24hrs – 48hrs once or twice week along with metformin and low dose metronimic chemo.

    I have few doubts here, please help us.
    1. Can you please specify which chemo drugs,that suites for Ovarian cancer to be given with this protocol? because Dr
    Lampidis, was discussing about a patient’s regime, who took FOLFOX with metronomic 2 DG but the chemo is usually
    is given for pancreatic cancer.
    2. Can you please also suggest on I.V 2DG dosage per kg body weight
    3. And metronomic 2DG should be given followed by chemo?
    4. Can we also continue giving other metabolic drugs parallel ?
    4. what are precautions to be taken, few articles mentioned about hypoglycemia,cardiac arrest.
    5. Dr Lampidis was discussing about an ovarian cancer patient, who went into remission in 2 months after starting
    metronomic 2 DG with low dose chemo, can you please share if you have the chemo regime of that patient.
    6 We have contacted the German pharmacy for I.V 2DG by providing the prescription but they are not sure if they can
    ship to India, Im behind them, following up on this.
    7. Can you please share your skype id on my email id, so that we along with our doctor can have quick call and get
    clarified on few technical doubts, this would be great help.

    Thanks,
    Karthik,
    skype id: karthikreddie.

    1. Hi Karthik,

      1. I will need to check and see if I find the info on the treatment protocol of the women that had CR using low dose chemo -IPT and 2DG metronomic. If I find it I will let you know.
      2. Most of the people/adults using it, are using it in the range of 1-2g/48h regardless of the weight
      3. Given after chemo
      4. Yes
      4. While there is no major side effect reported so far, and the 2DG dose is very low (in order not to be “detected” by the body and go to the tumor, thsi is still an experimental treatment so I can not make a statement on that – the best for you is to look at the previous clinical trials on 2DG – I am sure pro Lampidis addressed that in the discussion with your doctor
      5. If I find it I will share it with you
      6. I understand – I understood from other patients that sometimes the pharmacy may have an issue with sending products to other continents as some products have to stay at a certain temperature
      7. If there are specific questions, please let me know here and will try yo answer when I find the time – others may also be able to help so it’s best to address the questions here.

      Kind regards,
      Daniel

      1. Hi Daniel,

        I had contact German Pharmacy Burg Apo for I.V 2 DG.
        We had provided all the required documents and prescription but they helpless for sending the medicine, as it need to be stored at 2- 8 C temperature.
        And a private logistics costing really a huge amount which is 30 ( 60,000 INR)times more than the medicine cost(2000INR).
        Can you please suggest a way to get this, is their any other pharmacy or source ,we can get from.
        We had got all the details from Dr Lampidis but getting medicine from Burg Apo is delaying the treatment.Kindly help.

        Regards,
        Karthik,
        +91 9533817143,
        skype: karthikreddie

        1. Hi Karthik,

          The options people used:
          – they travelled to Germany to pick up the 2DG from the pharmacy – that is much cheaper than 30x the medicine cost. If we buy 20 2DG bags, they will be probably about 600 euro and the flight ticket probably about the same from India to Frankfurt
          – they bought it as powder from chemical supplier and converted themselves in intravenous solution such as discussed here https://www.cancertreatmentsresearch.com/2-deoxyglucose-2-dg/ but this would take more time and same costs as just buying it from pharmacy ready made
          So I would really go for the first option if I would want to access 2DG. If not, I would search for other treatment options – there are many other treatment options discussed on this website.

          Did your mom ever had conventional therapy?

          Kind regards,
          Daniel

          1. Hi Daniel,

            1.I had already brought 99% oral 2 DG powder from china, can we sterilize it and use for intravenous form?
            2. can gamma sterilization of the 2 DG powder can be mixed with saline and used for I.V metronomic way?
            3. My mom had undergone conventional treatments, but nothing helped her.
            a. cytoreductive surgery
            b. 6 cycles chemo (carboplatin+ paclitaxel)
            c. HIPEC surgery
            d. Avastin + Gemcitabine
            e. Nivolumab
            f. off label drugs + medium dose chemo (currently).
            My mom’s cancer is platinum resistant epethelial mucinous ovarian cancer, BRCA negative and MSI-H.
            Kindly suggest.

            Thanks,
            Karthik.

            1. HI Karthik,

              1. For intravenous preparations I would only use powder from western suppliers that I trust 100%. I would not take the risk to put a substance that I do not have tested in the blood of anybody. Some suppliers from China can be trusted others not.
              2. For the procedure that I use to create solution for IV out of powder, please see my post on 3BP and 2DG (I already sent you the link above – please read)
              If you have any specific question, please let me know.

              Kind regards,
              Daniel

          2. Hi Daniel,

            We couldnt get iv 2DG from germany.so, we are doing gamma irradiation for 2dg powder and filtering using 0.22 um syringe filter and use for I.V protocol.

            Can you please help on my below doubts.

            1. Which infusion should be given first is it I.V metronomic 2 DG and then low dose chemo or is it first chemo and then
            I.V 2 DG?

            2. We wanted to give 1g 2DG dose, so shall we mix 1g 2 DG in 100 ml NS and give for 24 hours ? In 500 ml NS for 24
            hrs? Or 100 ml NS for 9-10 hrs would also be fine?

            3. Can you please suggest the chemo drugs of the ovarian stage 4 patient who had remission with this protocol,if you
            have handy.
            For now our doctor thinking to give low dose carboplatin + gemcitabine along with metronomic iv 2dg.

            4. When to give metformin? Can I give 500mg x 3 times a day ?

            5. Should she be on fasting for making 2DG to be effective?
            6. In New Approach for cancer topic, you mentioned about a pancreatic who had good response with 2DG is going to
            start their own website on sharing experience about 2 DG protocol, please share if you have that info by any chance.

            Kindly help.Thank you.

            Regards,
            Karthik,
            +91 9533817143.

          3. Hi Sir,

            A Gentle Reminder.
            Can you please share the password ([email protected]) of OVC IPT protocol you shared. We had got the required medication iv 2DG and chemo drugs, wanted to start her on treatment without delay. Thanks for your help.

            Regards,
            Karthik

            1. Hi K,

              I already did that via a reply to one of your e-mails. Here is when I replied (my time) to your e-mail: Fri, Feb 28, 1:06 AM (1 day ago)
              Please check.

              Kind regards,
              Daniel

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