The below series of articles could serve as an exciting treatment approach for especially skin cancer, thuo0gh perhaps others as well (e.g. colon, prostate, etc.). It is quite remarkable how large an effect ultrasound pre-treatment with quercetin had on cell viability. I am not sure, though it appears that hand held ultrasound devices can be purchased cheaply online (yet it is not clear to me whether the 20 kHz, 2 w/cm-2 specified in the article can be obtained with such online devices). Nonetheless, this appears to be an exciting avenue to further investigate. Perhaps combinations might intensify this effect?
This article reports an 80 fold reduction in LC for quercetin in cells pretreated with 60 seconds of ultrasound. Quite startling!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362095/
Methods of increasing penetration of pharmaceuticals across the skin barrier are mentioned here.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4725305/
pH sensitive nanoparticles for cancer specific release of quercetin.
https://www.mdpi.com/2073-4360/11/12/2026
This article reports an 80 fold reduction in LC for quercetin in cells pretreated with 60 seconds of ultrasound. Quite startling!
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2362095/
Amazing!
Johan, could it really be as easy as that? Pre-treat with US with a $50 device bought online; and then perhaps use iontophoresis or possibly a formulation of quercetin to treat skin cancer? 80 fold enhancement is startling. I am also wondering whether a DYI chitosan formulation might encapsulate nutraceuticals such as quercetin.
2019 has been a big year; 2020 will be bigger!
Best Wishes, J
You'd think there would be more interest in the use of ultrasound in the treatment of diseases, it's been about 90 years since Royal Rife successfully cured people of cancer using a similar technique, although I don't think anyone knows the frequencies he used(?)
Best wishes
Johan
